Biased Signaling Atlas

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	AssayType	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	1153	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	12668023	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026874	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	30026875	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	3341	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	6603851	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	933	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	939	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	985	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1160786	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1161520	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	CHEMBL588	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	DB00800	8409	58	None	6	12	Human	9.7	pAC50	=	9.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
	2407	10145	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	59227	10145	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	941	10145	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	CHEMBL1303	10145	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	DB05271	10145	76	None	-7	17	Human	9.0	pAC50	=	9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
	138	9855	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	1882	9855	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	5280723	9855	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	CHEMBL495	9855	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	DB00770	9855	88	None	-6	10	Human	8.0	pAC50	=	8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	13	3	4	3.5	CCCCC[C@@H](/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O)O	10.1038/s41467-023-40064-9
	4150	7575	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	5288	7575	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	644019	7575	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	CHEMBL190461	7575	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	DB09061	7575	39	None	-154	15	Human	5.0	pAC50	=	5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1038/s41467-023-40064-9
	2389	10104	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	5073	10104	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	96	10104	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	CHEMBL85	10104	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	DB00734	10104	118	None	-257	29	Human	6.0	pAC50	=	6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
	2105	9828	37	None	-61	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	47811	9828	37	None	-61	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	48	9828	37	None	-61	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	CHEMBL531	9828	37	None	-61	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	DB01186	9828	37	None	-61	24	Human	8.0	pAC50	=	8.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
	3042	8196	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	355	8196	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	868	8196	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	CHEMBL1123	8196	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	DB00804	8196	35	None	-457	17	Human	6.0	pAC50	=	6.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	7	0	3	4.4	CCN(CCOC(=O)C1(CCCCC1)C1CCCCC1)CC	10.1038/s41467-023-40064-9
	17676	13844	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	5281082	13844	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL1085	13844	29	None	-77	13	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
	11001318	84925	69	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	2	1	3	4.5	O=C(O)c1ccc2nc(-c3cc(Cl)cc(Cl)c3)oc2c1	10.1038/s41467-023-40064-9
	CHEMBL2103837	84925	69	None	1	3	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	2	1	3	4.5	O=C(O)c1ccc2nc(-c3cc(Cl)cc(Cl)c3)oc2c1	10.1038/s41467-023-40064-9
	135398737	7745	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	38	7745	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	722	7745	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL42	7745	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	DB00363	7745	93	None	-112	43	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
	36811	8236	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	535	8236	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	937	8236	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL926	8236	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00841	8236	37	None	-467	17	Human	4.9	pAC50	=	4.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	4	4	3.0	CC(CCc1ccc(cc1)O)NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	25102847	84996	93	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	CHEMBL2105717	84996	93	None	-6	10	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
	228	7233	28	None	-14	19	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	33	7233	28	None	-14	19	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	6005	7233	28	None	-14	19	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	CHEMBL53	7233	28	None	-14	19	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	DB00714	7233	28	None	-14	19	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
	168871	95905	14	None	1	13	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	CHEMBL2365712	95905	14	None	1	13	Human	7.9	pAC50	=	7.9	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	563	4	3	6	2.1	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
	6077	157477	31	None	-44	11	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	CHEMBL39560	157477	31	None	-44	11	Human	5.9	pAC50	=	5.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
	54682461	91461	62	None	-3	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	CHEMBL222559	91461	62	None	-3	12	Human	4.9	pAC50	=	4.9	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	602	11	2	6	7.3	CCC[C@@]1(CCc2ccccc2)CC(O)=C([C@H](CC)c2cccc(NS(=O)(=O)c3ccc(C(F)(F)F)cn3)c2)C(=O)O1	10.1038/s41467-023-40064-9
	55645	91145	8	None	-53	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	CHEMBL2218861	91145	8	None	-53	11	Human	6.8	pAC50	=	6.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	395	7	2	4	2.1	CCCN1CC(NS(=O)(=O)N(CC)CC)CC2Cc3c(O)cccc3CC21	10.1038/s41467-023-40064-9
	31101	7516	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	35	7516	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	403	7516	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	CHEMBL493	7516	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	DB01200	7516	40	None	-776	29	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
	26879	44068	63	None	13	2	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	204	1	0	3	2.1	c1ccc([C@H]2CN3CCSC3=N2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1454	44068	63	None	13	2	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	204	1	0	3	2.1	c1ccc([C@H]2CN3CCSC3=N2)cc1	10.1038/s41467-023-40064-9
	24826799	17570	104	None	-50	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	CHEMBL1171837	17570	104	None	-50	20	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	532	4	1	6	4.5	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	10.1038/s41467-023-40064-9
	2335	18620	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	8478	18620	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL1182210	18620	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	CHEMBL221753	18620	22	None	-36	34	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
	4066	211405	78	None	-1071	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	CHEMBL73451	211405	78	None	-1071	16	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	322	2	0	3	4.6	c1ccc2c(c1)Sc1ccccc1N2CC1CN2CCC1CC2	10.1038/s41467-023-40064-9
	154257	185398	67	None	-77	19	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	CHEMBL46740	185398	67	None	-77	19	Human	4.8	pAC50	=	4.8	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	7	2	5	6.3	Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12	10.1038/s41467-023-40064-9
	54454	12030	88	None	-2	14	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	CHEMBL1064	12030	88	None	-2	14	Human	5.8	pAC50	=	5.8	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
	60606	68334	73	None	-9	8	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1771	68334	73	None	-9	8	Human	4.7	pAC50	=	4.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	321	3	0	4	3.7	COC(=O)[C@H](c1ccccc1Cl)N1CCc2sccc2C1	10.1038/s41467-023-40064-9
	102	10899	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	3659	10899	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	8969	10899	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	CHEMBL15245	10899	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	DB01392	10899	48	None	-295	20	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
	5284537	40387	31	None	2	2	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	374	1	1	3	4.0	CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	CHEMBL142130	40387	31	None	2	2	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	374	1	1	3	4.0	CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)[C@H]3CC[C@@]21C	10.1038/s41467-023-40064-9
	1201549	7384	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	333	7384	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	7601	7384	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL1201203	7384	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL438151	7384	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	DB00245	7384	24	None	-10471	26	Human	4.7	pAC50	=	4.7	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	4	0	2	4.4	CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
	2136	9869	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	4768	9869	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	7268	9869	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	CHEMBL753	9869	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	DB00925	9869	30	None	-43	21	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	10.1038/s41467-023-40064-9
	10184665	10763	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	4799	10763	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	7353	10763	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	CHEMBL1198857	10763	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	DB09082	10763	51	None	-1288	10	Human	5.7	pAC50	=	5.7	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	485	16	4	6	4.6	OCc1cc(ccc1O)[C@H](CNCCCCCCOCCOCc1c(Cl)cccc1Cl)O	10.1038/s41467-023-40064-9
	1209	8439	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	203	8439	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	3386	8439	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL41	8439	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00472	8439	75	None	-36	20	Human	5.6	pAC50	=	5.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
	55483	211876	40	None	-144	11	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	CHEMBL77622	211876	40	None	-144	11	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	356	13	4	4	3.6	Oc1ccc(CCNCCCCCCNCCc2ccccc2)cc1O	10.1038/s41467-023-40064-9
	46780481	114308	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	9903970	114308	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3187365	114308	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	CHEMBL3544974	114308	20	None	-251	15	Human	6.6	pAC50	=	6.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
	71137	85018	18	None	-	1	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	12	2	9	2.7	CCOC(=O)Oc1ccc(CCNC(=O)[C@H](CCSC)NC(C)=O)cc1OC(=O)OCC	10.1038/s41467-023-40064-9
	CHEMBL2106351	85018	18	None	-	1	Human	6.6	pAC50	=	6.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	470	12	2	9	2.7	CCOC(=O)Oc1ccc(CCNC(=O)[C@H](CCSC)NC(C)=O)cc1OC(=O)OCC	10.1038/s41467-023-40064-9
	104850	10103	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	4150	10103	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	743	10103	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	CHEMBL111	10103	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	DB06155	10103	96	None	-2290	28	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	462	4	1	4	5.9	Clc1ccc(cc1)c1c(C)c(nn1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1	10.1038/s41467-023-40064-9
	135564886	21265	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	135673376	21265	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	137157436	21265	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	145948239	21265	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71587099	21265	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	CHEMBL1201304	21265	5	None	-8	25	Human	4.6	pAC50	=	4.6	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	752	14	1	6	8.7	CC1(C)C(/C=C/C=C/C=C/C=C2\N(CCCCS(=O)(=O)O)c3ccc4ccccc4c3C2(C)C)=[N+](CCCCS(=O)(=O)[O-])c2ccc3ccccc3c21	10.1038/s41467-023-40064-9
	71496458	122342	87	None	-72	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL3353410	122342	87	None	-72	16	Human	4.6	pAC50	=	4.6	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	499	10	2	8	4.5	C=CC(=O)Nc1cc(Nc2nccc(-c3cn(C)c4ccccc34)n2)c(OC)cc1N(C)CCN(C)C	10.1038/s41467-023-40064-9
	150	9287	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1764	9287	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	8226	9287	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	CHEMBL1201356	9287	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	DB00353	9287	21	None	-22	17	Human	8.5	pAC50	=	8.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	10.1038/s41467-023-40064-9
	1960	9632	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	439260	9632	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	505	9632	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL1437	9632	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00368	9632	67	None	-25	19	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	213046	9164	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	4168	9164	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	7461	9164	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	CHEMBL1237021	9164	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	DB08815	9164	59	None	-107	17	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
	2146	9874	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	485	9874	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	6041	9874	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL1215	9874	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	DB00388	9874	67	None	-851	15	Human	5.5	pAC50	=	5.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL508338	195745	0	None	-89	15	Human	5.5	pAC50	=	5.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
	1028	7079	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	139148732	7079	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	479	7079	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	5816	7079	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	CHEMBL679	7079	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	DB00668	7079	71	None	-1	19	Human	7.5	pAC50	=	7.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1038/s41467-023-40064-9
	135398745	9688	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	47	9688	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	CHEMBL715	9688	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	DB00334	9688	112	None	-12	33	Human	6.5	pAC50	=	6.5	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
	135409453	10545	41	None	-208	36	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	226	10545	41	None	-208	36	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	CHEMBL76370	10545	41	None	-208	36	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
	10531	8202	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	121	8202	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	888	8202	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL1732	8202	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00320	8202	21	None	-1949	26	Human	6.5	pAC50	=	6.5	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	37	7565	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	460	7565	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	54746	7565	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201087	7565	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	DB00248	7565	60	None	-32	12	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
	1816	9318	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	4205	9318	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	7241	9318	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	CHEMBL654	9318	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	DB00370	9318	102	None	-562	12	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1038/s41467-023-40064-9
	2865	10915	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	59	10915	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	60854	10915	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL708	10915	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	DB00246	10915	73	None	-11	20	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
	68555	109889	21	None	3	7	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	CHEMBL307739	109889	21	None	3	7	Human	7.4	pAC50	=	7.4	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	307	7	1	5	2.6	CNCCc1ccc(OC(=O)C(C)C)c(OC(=O)C(C)C)c1	10.1038/s41467-023-40064-9
	214	10632	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	2740	10632	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	5566	10632	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	66064	10632	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	CHEMBL422	10632	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	DB00831	10632	58	None	-16	28	Human	6.4	pAC50	=	6.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
	25382	15929	37	None	-120	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	CHEMBL110094	15929	37	None	-120	21	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	291	3	0	1	4.7	CN(C)CCC=C1c2ccccc2C(C)(C)c2ccccc21	10.1038/s41467-023-40064-9
	49806720	66854	99	None	-9	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	CHEMBL1738797	66854	99	None	-9	4	Human	5.4	pAC50	=	5.4	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	482	3	1	5	4.8	CCc1cc2c(cc1N1CCC(N3CCOCC3)CC1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O	10.1038/s41467-023-40064-9
	5472	212597	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL1717	212597	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	CHEMBL833	212597	75	None	-7	16	Human	5.3	pAC50	=	5.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	263	2	0	2	4.0	Clc1ccccc1CN1CCc2sccc2C1	10.1038/s41467-023-40064-9
	2601	10552	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	443951	10552	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	56	10552	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	CHEMBL73151	10552	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	DB13399	10552	33	None	-45	17	Human	7.3	pAC50	=	7.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
	242	7258	124	None	-794	32	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	34	7258	124	None	-794	32	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	60795	7258	124	None	-794	32	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	CHEMBL1112	7258	124	None	-794	32	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	DB01238	7258	124	None	-794	32	Human	5.3	pAC50	=	5.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
	103	10925	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	2875	10925	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	5736	10925	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	CHEMBL285802	10925	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	DB09225	10925	61	None	-79	22	Human	6.3	pAC50	=	6.3	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
	3718	58811	73	None	-	1	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	281	3	1	2	3.0	CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	CHEMBL15870	58811	73	None	-	1	Human	6.3	pAC50	=	6.3	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	281	3	1	2	3.0	CC(C(=O)O)c1ccc(N2Cc3ccccc3C2=O)cc1	10.1038/s41467-023-40064-9
	1043	8363	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	149	8363	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	8223	8363	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	CHEMBL442	8363	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	DB00696	8363	14	None	-5011	23	Human	6.2	pAC50	=	6.2	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
	1353	8692	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	3559	8692	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	86	8692	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	CHEMBL54	8692	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	DB00502	8692	93	None	-26	39	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
	2220	9908	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	27400	9908	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	93	9908	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	CHEMBL294951	9908	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	DB06153	9908	82	None	-234	17	Human	6.2	pAC50	=	6.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	295	0	0	2	4.4	CN1CCC(=C2c3ccsc3CCc3c2cccc3)CC1	10.1038/s41467-023-40064-9
	2337	10030	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	50	10030	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5002	10030	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL716	10030	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	DB01224	10030	77	None	-66	29	Human	5.2	pAC50	=	5.2	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
	5852	9395	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	9931891	9395	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	CHEMBL239226	9395	55	None	-91	6	Human	5.1	pAC50	=	5.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	419	11	1	5	4.9	OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C	10.1038/s41467-023-40064-9
	16363	7383	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	312	7383	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	9215	7383	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	CHEMBL297302	7383	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	DB12867	7383	53	None	-1445	21	Human	5.1	pAC50	=	5.1	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
	1830	9368	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	207	9368	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	23897	9368	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	CHEMBL460	9368	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	DB01618	9368	44	None	-81	11	Human	6.1	pAC50	=	6.1	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
	681	8247	72	None	-77	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	940	8247	72	None	-77	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	947	8247	72	None	-77	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	CHEMBL59	8247	72	None	-77	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	DB00988	8247	72	None	-77	14	Human	5.0	pAC50	=	5.0	Functional	Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAgonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
	212	10578	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	2639	10578	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	941651	10578	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	CHEMBL1201	10578	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	DB01623	10578	47	None	-41	22	Human	6.0	pAC50	=	6.0	Functional	Antagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer methodAntagonist activity at human DRD1 in an in vitro cell-based assay measured by time-resolved fluorescence resonance energy transfer method	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
	10020353	20661	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL1196161	20661	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL556024	20661	18	None	12022	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
	133538	10391	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	8443	10391	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL574558	10391	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	146025713	178390	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465393	178390	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025713	178390	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465393	178390	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	173204	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	173204	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	173204	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4277264	173204	19	None	95	4	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75202022	177589	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1016/j.ejmech.2022.114378
	CHEMBL4453318	177589	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1016/j.ejmech.2022.114378
	16219951	178839	2	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL4472022	178839	2	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	75202022	177589	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4453318	177589	2	None	1	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	173871	10386	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	936	10386	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1193571	10386	2	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/acs.jmedchem.8b00435
	46869265	23029	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
	CHEMBL1224527	23029	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
	10742	10389	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	1225	10389	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	CHEMBL35354	10389	31	None	4	3	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
	92044504	178506	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4467080	178506	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	92044504	178506	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4467080	178506	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	1241	106955	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL288090	106955	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	CHEMBL552611	106955	24	None	22	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/acs.jmedchem.8b00435
	44320092	168666	0	None	346	2	Human	9.0	pEC50	=	9.0	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL415080	168666	0	None	346	2	Human	9.0	pEC50	=	9.0	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	167715	9651	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	969	9651	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL225230	9651	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	167715	9651	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	969	9651	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL225230	9651	14	None	-151	4	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	1242	10385	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	935	10385	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	CHEMBL286080	10385	27	None	1	3	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/acs.jmedchem.8b00435
	10506	9302	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	86290953	9302	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	CHEMBL3421729	9302	20	None	20	3	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.8b01767
	135	176061	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	3702506	176061	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	CHEMBL441343	176061	123	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	138	1	2	2	1.1	O=C(O)c1ccc(O)cc1	10.1021/acs.jmedchem.8b01767
	75201961	176409	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4437012	176409	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	75201961	176409	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4437012	176409	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acs.jmedchem.9b00351
	146025701	177350	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	CHEMBL4450338	177350	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	146025701	177350	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	CHEMBL4450338	177350	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
	44320024	113844	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315750	113844	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442480	182049	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	182049	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	44320050	113608	0	None	1	3	Rat	8.8	pEC50	=	8.8	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL314459	113608	0	None	1	3	Rat	8.8	pEC50	=	8.8	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442480	182049	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	CHEMBL4572614	182049	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
	146025715	182975	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4593703	182975	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025715	182975	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4593703	182975	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3[nH]ncc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	122324	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	6077	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	CHEMBL86931	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
	122324	6993	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	6077	6993	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	CHEMBL86931	6993	22	None	4	4	Rat	8.7	pEC50	=	8.7	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm9502100
	122324	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	6077	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	CHEMBL86931	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	90134269	180985	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4548284	180985	1	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	75201899	178695	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	CHEMBL4469983	178695	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
	71722299	109257	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397383	109257	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040217	109257	0	None	-3	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	44282985	127258	0	None	-1	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL35426	127258	0	None	-1	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	146025707	177886	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4457872	177886	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44320256	213092	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87172	213092	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	13720688	18326	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1180542	18326	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL129634	18326	0	None	1	2	Rat	7.0	pEC50	=	7	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	329	3	3	4	3.1	C=CCN1CCc2c(cc(O)c(O)c2F)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	146025696	176482	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4437975	176482	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	44331742	11212	0	None	-	1	Rat	6.0	pEC50	=	6	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	269	3	3	3	2.7	Oc1ccc2c(c1O)CCC(NCc1ccccc1)C2	10.1021/jm9502100
	CHEMBL101617	11212	0	None	-	1	Rat	6.0	pEC50	=	6	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	269	3	3	3	2.7	Oc1ccc2c(c1O)CCC(NCc1ccccc1)C2	10.1021/jm9502100
	14708665	174984	1	None	-	1	Rat	5.0	pEC50	=	5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	CHEMBL43345	174984	1	None	-	1	Rat	5.0	pEC50	=	5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	146025696	176482	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4437975	176482	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	7	5.0	COC(=O)c1cccn2c(-c3ccc(Oc4nccc5occc45)cc3C)cnc12	10.1021/acs.jmedchem.9b00351
	146025707	177886	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4457872	177886	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	397	4	0	6	5.7	Cc1cc(N(c2nccc3occc23)C(C)C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	75201901	173204	19	None	95	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	173204	19	None	95	4	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	146034919	198979	3	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2cccc(OC(F)F)c2)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5204559	198979	3	None	-	1	Human	5.0	pEC50	=	5.0	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2cccc(OC(F)F)c2)cc1	10.1021/acs.jmedchem.2c00949
	146025721	178488	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4466769	178488	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	10684715	167419	0	None	-	1	Goldfish	8.0	pEC50	=	8.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL41132	167419	0	None	-	1	Goldfish	8.0	pEC50	=	8.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	71563083	94347	0	None	19	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335737	94347	0	None	19	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	75201901	173204	19	None	95	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
	CHEMBL4277264	173204	19	None	95	4	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
	146025721	178488	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4466769	178488	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1c(Oc2nccc3occc23)ccc(-c2cccc3nccn23)c1C	10.1021/acs.jmedchem.9b00351
	44276535	105165	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	CHEMBL275379	105165	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	44417647	88936	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	CHEMBL1203924	88936	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	CHEMBL216945	88936	0	None	-52	3	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
	24878061	148189	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
	CHEMBL384046	148189	0	None	-4	2	Human	6.0	pEC50	=	6.0	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
	146025709	181360	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4556763	181360	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	145982261	173511	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	CHEMBL4283176	173511	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	146192959	177294	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1cc(F)ccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4449550	177294	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1cc(F)ccc1Cl	10.1021/acsmedchemlett.9b00547
	44282985	127258	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL35426	127258	0	None	-1	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	279	0	0	3	3.2	CN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	130442557	173852	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4289538	173852	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	146025709	181360	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4556763	181360	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	423	4	0	6	6.2	Cc1cc(N(c2nccc3occc23)C2CCCC2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	71722297	109249	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397382	109249	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040156	109249	0	None	-34	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	85090332	187498	0	None	-9	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4755709	187498	0	None	-9	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	90134199	179021	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4474245	179021	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	90134199	179021	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4474245	179021	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	361	5	0	6	5.1	CCOc1ncnc(C)c1-c1ccc(Oc2nccc3occc23)cc1C	10.1021/acs.jmedchem.9b00351
	44320303	170746	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL420788	170746	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	130442471	182863	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4591207	182863	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	681	8247	72	None	-77	14	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	940	8247	72	None	-77	14	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	947	8247	72	None	-77	14	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	CHEMBL59	8247	72	None	-77	14	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	DB00988	8247	72	None	-77	14	Human	6.9	pEC50	=	6.9	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm0604979
	44554468	113045	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099225	113045	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139011	113045	0	None	-151	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	233	1	1	3	1.6	CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	146025716	180744	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4541632	180744	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44276651	106516	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL284959	106516	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	85090319	187389	0	None	-5	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4754602	187389	0	None	-5	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	130442534	173676	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4286177	173676	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	2030130	27751	16	None	-6	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL1311333	27751	16	None	-6	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	146025716	180744	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4541632	180744	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	316	3	0	5	4.2	Cc1cc(Oc2ccccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	145988779	174058	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
	CHEMBL4293356	174058	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
	44320328	213007	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
	CHEMBL86669	213007	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
	10689581	106939	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL287931	106939	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	3106	55294	16	None	-25	3	Rat	4.9	pEC50	=	4.9	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1021/jm00390a009
	CHEMBL15564	55294	16	None	-25	3	Rat	4.9	pEC50	=	4.9	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1021/jm00390a009
	168278276	197895	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	295	5	1	3	2.6	CNS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187937	197895	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	295	5	1	3	2.6	CNS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	146192950	182810	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	397	4	2	3	3.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1F	10.1021/acsmedchemlett.9b00547
	CHEMBL4590150	182810	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	397	4	2	3	3.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1F	10.1021/acsmedchemlett.9b00547
	168280742	197863	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	230	4	0	2	3.5	O=Cc1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187578	197863	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	230	4	0	2	3.5	O=Cc1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	130442471	182863	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4591207	182863	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	146192960	178298	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4464150	178298	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44320116	170887	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL420972	170887	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	117720272	125592	3	None	18	3	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	CHEMBL3421730	125592	3	None	18	3	Human	7.9	pEC50	=	7.9	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	1242	10385	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	935	10385	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	CHEMBL286080	10385	27	None	1	3	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.12.016
	146025697	182130	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4574454	182130	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	168276676	197241	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	280	4	0	3	3.1	CS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5178743	197241	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	280	4	0	3	3.1	CS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	146025697	182130	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4574454	182130	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	345	4	1	5	4.1	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc(C(N)=O)c1	10.1021/acs.jmedchem.9b00351
	130442561	173672	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4286110	173672	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	161665	179364	35	None	-28	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL448891	179364	35	None	-28	3	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	85090324	187471	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4755481	187471	0	None	-4	2	Human	6.9	pEC50	=	6.9	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	6603820	102549	19	None	1	7	Human	7.9	pEC50	=	7.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL25856	102549	19	None	1	7	Human	7.9	pEC50	=	7.9	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	146025712	182262	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4577432	182262	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	10666053	107162	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL289927	107162	0	None	-	1	Goldfish	6.9	pEC50	=	6.9	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	146025703	178046	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4460394	178046	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	75201901	173204	19	None	95	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	173204	19	None	95	4	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	146025703	178046	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	CHEMBL4460394	178046	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	378	3	0	6	4.9	Cc1ncc2nccn2c1-c1cc(F)c(Oc2nccc3occc23)c(F)c1	10.1021/acs.jmedchem.9b00351
	15696481	86441	0	None	75	2	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL2115213	86441	0	None	75	2	Human	6.9	pEC50	=	6.9	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	146025712	182262	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4577432	182262	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	366	3	0	5	5.4	Cc1cc(Oc2nccc3ccccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	132435	137487	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL130795	137487	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL368456	137487	6	None	8	2	Rat	7.8	pEC50	=	7.8	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	345	3	3	4	3.6	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	146025704	179127	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4475848	179127	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44554818	111043	0	None	-89	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099234	111043	0	None	-89	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44554472	113060	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099226	113060	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139040	113060	0	None	-1071	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	247	2	1	3	2.0	CCCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	85090328	187814	0	None	-6	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4759339	187814	0	None	-6	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090323	188701	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4779641	188701	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
	146025813	182366	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	182366	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025813	182366	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	182366	0	None	-2	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	90134304	173293	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b00435
	CHEMBL4278861	173293	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b00435
	146025821	176450	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4437552	176450	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025821	176450	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4437552	176450	0	None	100	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025820	180001	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4523054	180001	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025820	180001	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4523054	180001	0	None	6	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	85090329	189461	0	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4789255	189461	0	None	-8	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	137364078	199004	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	4	0	3	3.7	CN=S(C)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5204914	199004	0	None	-	1	Human	4.8	pEC50	=	4.8	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	4	0	3	3.7	CN=S(C)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	3246443	44460	2	None	-16	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL1457510	44460	2	None	-16	3	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assayAgonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	146025704	179127	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4475848	179127	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	1	6	4.9	Cc1cc(Nc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44320053	212552	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL82899	212552	0	None	3	2	Human	7.8	pEC50	=	7.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	11938	9190	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	146192952	9190	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4468760	9190	7	None	11	4	Human	7.8	pEC50	=	7.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44287454	20000	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL1191276	20000	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL542351	20000	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	146025718	181972	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4570859	181972	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	117720272	125592	3	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	125592	3	None	-18	3	Rat	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of rat D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	146025718	181972	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4570859	181972	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	3	1	6	4.2	Cc1cc(Oc2nccc(O)c2C)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	85090333	188080	0	None	-10	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4762375	188080	0	None	-10	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	76284419	190027	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796389	190027	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
	85090325	186528	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4744261	186528	0	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	75201901	173204	19	None	95	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b00435
	CHEMBL4277264	173204	19	None	95	4	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b00435
	10854877	148793	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL38757	148793	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	10733562	153792	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL39266	153792	0	None	-	1	Goldfish	6.8	pEC50	=	6.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
	1242	10385	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	935	10385	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	CHEMBL286080	10385	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assayAgonist activity at dopamine D1 receptor assessed as [35S]GTPgammaS binding in cell-based assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2012.05.057
	136326241	186207	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4740312	186207	0	None	-4	2	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	146192966	182095	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acsmedchemlett.9b00547
	CHEMBL4573538	182095	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acsmedchemlett.9b00547
	44319988	212858	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85552	212858	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10758745	107209	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115373	107209	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL290438	107209	0	None	-	1	Goldfish	5.8	pEC50	=	5.8	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	44276414	104404	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL27101	104404	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	155548298	180530	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	473	6	2	5	3.9	C[C@H]1c2cccc(-c3cnn(CCO)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4536851	180530	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	473	6	2	5	3.9	C[C@H]1c2cccc(-c3cnn(CCO)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	44320001	212795	0	None	-3	2	Rat	7.7	pEC50	=	7.7	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84983	212795	0	None	-3	2	Rat	7.7	pEC50	=	7.7	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	1242	10385	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	935	10385	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	CHEMBL286080	10385	27	None	1	3	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2014.09.024
	146025729	180938	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4546823	180938	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44276652	106270	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	CHEMBL283247	106270	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
	146025729	180938	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4546823	180938	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	6	4.9	FC(F)(F)c1cc(Oc2nccn3ccnc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	85090322	186238	0	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740678	186238	0	None	-4	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	85090321	189592	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4790909	189592	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	168294420	199289	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccccc2OC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5209228	199289	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccccc2OC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	6603820	102549	19	None	1	7	Human	7.7	pEC50	=	7.7	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
	CHEMBL25856	102549	19	None	1	7	Human	7.7	pEC50	=	7.7	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
	44554820	113063	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099222	113063	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139044	113063	0	None	-31	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	307	4	1	4	2.7	CCCN1C[C@H](CSC)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	146025724	179043	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4474567	179043	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025819	182431	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4581262	182431	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025819	182431	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4581262	182431	0	None	3	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	385	2	0	5	3.9	CC(=O)Oc1c(Cl)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025724	179043	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4474567	179043	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	363	3	0	5	5.2	Fc1cc(-c2cccc3nccn23)cc(F)c1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	85090334	187404	0	None	-11	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4754761	187404	0	None	-11	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090331	188232	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4764398	188232	0	None	-6	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	12668019	17011	8	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
	CHEMBL1160787	17011	8	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
	44320061	112809	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313304	112809	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	14809027	113806	0	None	3	3	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315468	113806	0	None	3	3	Human	8.7	pEC50	=	8.7	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	122324	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	6077	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	CHEMBL86931	6993	22	None	-4	4	Human	8.7	pEC50	=	8.7	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
	146025727	178464	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	178464	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025727	178464	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4466483	178464	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442572	178687	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	178687	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442572	178687	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4469848	178687	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	10506	9302	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	9302	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	9302	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Positive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	130442473	174116	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4294397	174116	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	130442473	174116	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4294397	174116	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	1153	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	12668023	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	30026874	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	30026875	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	3341	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	6603851	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	933	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	939	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	985	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1160786	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL1161520	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	CHEMBL588	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	DB00800	8409	58	None	6	12	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as reversal of Ro 20-1724 mediated decrease in cAMP accumulation after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
	681	8247	72	None	-77	14	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	940	8247	72	None	-77	14	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	947	8247	72	None	-77	14	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	CHEMBL59	8247	72	None	-77	14	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	DB00988	8247	72	None	-77	14	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2010.07.052
	75201899	178695	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1016/j.ejmech.2022.114378
	CHEMBL4469983	178695	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1016/j.ejmech.2022.114378
	201536	118245	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL3276140	118245	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	201536	118245	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL3276140	118245	4	None	1	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	351	2	0	5	3.3	CC(=O)Oc1ccc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	133741	205845	11	None	-38	2	Rat	4.7	pEC50	=	4.7	Functional	Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	276	7	2	3	2.6	CCCN(CCC)CCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	CHEMBL587	205845	11	None	-38	2	Rat	4.7	pEC50	=	4.7	Functional	Dopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	276	7	2	3	2.6	CCCN(CCC)CCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	90134211	180808	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4543306	180808	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	71722293	109252	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	CHEMBL2397380	109252	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	CHEMBL3040164	109252	0	None	-4	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
	44554984	111040	0	None	-208	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099231	111040	0	None	-208	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155541775	179823	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	CHEMBL4519136	179823	0	None	1	2	Human	6.7	pEC50	=	6.7	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	137364059	197099	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	3.4	C[S+]([O-])c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5176312	197099	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	3.4	C[S+]([O-])c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	168289194	198273	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	4.5	O=Cc1ccc(-c2ccccc2SC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5193714	198273	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	264	4	0	2	4.5	O=Cc1ccc(-c2ccccc2SC(F)F)cc1	10.1021/acs.jmedchem.2c00949
	10662054	91187	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114444	91187	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219803	91187	0	None	-	1	Goldfish	7.7	pEC50	=	7.7	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	90134211	180808	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4543306	180808	1	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	332	3	1	6	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1nc(N)cnc1C	10.1021/acs.jmedchem.9b00351
	155519631	177184	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	CHEMBL4448100	177184	0	None	15	2	Human	7.7	pEC50	=	7.7	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	145979741	173464	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4282096	173464	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	6917970	10463	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	8370	10463	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	CHEMBL487387	10463	61	None	40	3	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayAgonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
	44276412	104441	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL27117	104441	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	44320116	170887	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL420972	170887	0	None	-1	3	Rat	7.6	pEC50	=	7.6	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	44554649	111044	0	None	-457	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099235	111044	0	None	-457	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	328	4	1	6	1.6	CCCN1C[C@@H](Cn2cncn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44276557	106092	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL282136	106092	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	21936384	198291	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccc(OC(F)F)cc2)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5193924	198291	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	248	4	0	2	3.8	O=Cc1ccc(-c2ccc(OC(F)F)cc2)cc1	10.1021/acs.jmedchem.2c00949
	681	8247	72	None	-77	14	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	940	8247	72	None	-77	14	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	947	8247	72	None	-77	14	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	CHEMBL59	8247	72	None	-77	14	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	DB00988	8247	72	None	-77	14	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
	15696482	86334	0	None	21	2	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL2114209	86334	0	None	21	2	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	85090326	189552	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4790277	189552	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	44320218	213203	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
	CHEMBL87897	213203	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
	146025811	178540	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	178540	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025811	178540	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	178540	0	None	-416	2	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	10640108	91186	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114441	91186	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219802	91186	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	9841398	106295	4	None	-2	3	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL28338	106295	4	None	-2	3	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	44320267	212991	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86576	212991	0	None	1	2	Human	7.6	pEC50	=	7.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10588327	20553	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL1195441	20553	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL554571	20553	0	None	-	1	Goldfish	6.6	pEC50	=	6.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
	145990190	173632	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	CHEMBL4285528	173632	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
	85090337	190060	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4796761	190060	0	None	-6	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	21786101	162511	0	None	-38	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	261	2	2	3	2.7	CCCN1CCC[C@@H]2Cc3c(ccc(O)c3O)C[C@H]21	10.1016/j.bmc.2007.06.036
	CHEMBL405519	162511	0	None	-38	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	261	2	2	3	2.7	CCCN1CCC[C@@H]2Cc3c(ccc(O)c3O)C[C@H]21	10.1016/j.bmc.2007.06.036
	1241	106955	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	CHEMBL288090	106955	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	CHEMBL552611	106955	24	None	-22	3	Rat	7.6	pEC50	=	7.6	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00384a006
	228	7233	28	None	-14	19	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	33	7233	28	None	-14	19	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	6005	7233	28	None	-14	19	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	CHEMBL53	7233	28	None	-14	19	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	DB00714	7233	28	None	-14	19	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
	155541775	179823	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	CHEMBL4519136	179823	0	None	1	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	502	4	0	4	5.5	Clc1ccc(Br)c(CN2CCN([C@@H]3CC[C@@]4(c5ccc6c(c5)OCO6)C[C@H]4C3)CC2)c1	10.1021/acs.jmedchem.8b01767
	145979741	173464	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b00435
	CHEMBL4282096	173464	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulationAgonist activity at dopamine D1 receptor (unknown origin) assessed as increase in cAMP accumulation	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b00435
	145979741	173464	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1016/j.ejmech.2022.114378
	CHEMBL4282096	173464	1	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assayAgonist activity at human D1 receptor stably expressed in HEK293 cells assessed as induction of cAMP accumulation by HTRF assay	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1016/j.ejmech.2022.114378
	4901726	187578	9	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4756486	187578	9	None	-7	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	146025714	177077	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4446525	177077	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025714	177077	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4446525	177077	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	7	3.8	Cc1cc(Oc2nccn3ccnc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	130442473	174116	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4294397	174116	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
	146025730	178747	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4470740	178747	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025730	178747	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4470740	178747	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	4	5.2	FC(F)(F)c1cc(Oc2ccccn2)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	9796958	153356	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115374	153356	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL39230	153356	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL544814	153356	0	None	4	2	Goldfish	5.6	pEC50	=	5.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	44320304	113812	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	367	5	3	4	4.5	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNCc1ccccc1	10.1021/jm00112a034
	CHEMBL315516	113812	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	367	5	3	4	4.5	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNCc1ccccc1	10.1021/jm00112a034
	85090318	186224	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4740497	186224	0	None	-3	2	Human	6.6	pEC50	=	6.6	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	10758744	107283	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL291100	107283	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	10710466	163194	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL40667	163194	0	None	-	1	Goldfish	7.6	pEC50	=	7.6	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	2407	10145	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	59227	10145	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	941	10145	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	CHEMBL1303	10145	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	DB05271	10145	76	None	-7	17	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1016/j.bmc.2013.11.012
	146192958	177293	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4449549	177293	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(F)cccc1Cl	10.1021/acsmedchemlett.9b00547
	146192964	181489	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4559891	181489	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acsmedchemlett.9b00547
	10519435	178248	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL446350	178248	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	15981509	148736	1	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
	CHEMBL387250	148736	1	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
	10856744	66799	11	None	6	2	Rat	6.5	pEC50	=	6.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.	ChEMBL	210	2	3	5	1.2	NCCc1ccc(O)c2nc(O)sc12	10.1021/jm00390a009
	CHEMBL17357	66799	11	None	6	2	Rat	6.5	pEC50	=	6.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 60% of dopamine maximum effect.	ChEMBL	210	2	3	5	1.2	NCCc1ccc(O)c2nc(O)sc12	10.1021/jm00390a009
	85090330	187852	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	CHEMBL4759814	187852	0	None	-7	2	Human	6.5	pEC50	=	6.5	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
	10506	9302	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	9302	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	9302	20	None	20	3	Human	8.5	pEC50	=	8.5	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	44320050	113608	0	None	-1	3	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL314459	113608	0	None	-1	3	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44320357	213178	0	None	54	2	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87734	213178	0	None	54	2	Human	8.5	pEC50	=	8.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86293768	125593	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421836	125593	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	228	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	33	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6005	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL53	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	DB00714	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6604773	23030	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CC2	10.1016/j.bmc.2010.07.052
	CHEMBL1224528	23030	1	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CC2	10.1016/j.bmc.2010.07.052
	228	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	33	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6005	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	CHEMBL53	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	DB00714	7233	28	None	-14	19	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
	6852376	98374	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL1467585	98374	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL24077	98374	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	CHEMBL503958	98374	13	None	-1	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2007.06.036
	6603820	102549	19	None	-1	7	Rat	7.5	pEC50	=	7.5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	CHEMBL25856	102549	19	None	-1	7	Rat	7.5	pEC50	=	7.5	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9502100
	145867041	181308	4	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL4555682	181308	4	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in CHO cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	44320327	170203	0	None	1	2	Rat	7.5	pEC50	=	7.5	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL419680	170203	0	None	1	2	Rat	7.5	pEC50	=	7.5	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	1242	10385	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	935	10385	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	CHEMBL286080	10385	27	None	1	3	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assayAgonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	137364067	197854	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	5	1	3	4.1	CCS(=N)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5187471	197854	0	None	-	1	Human	4.5	pEC50	=	4.5	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	293	5	1	3	4.1	CCS(=N)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	10709445	108140	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115377	108140	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL296993	108140	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	3033200	181306	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	CHEMBL4555547	181306	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	3033200	181306	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	CHEMBL4555547	181306	5	None	-616	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
	117720272	125592	3	None	-34	3	Mouse	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	125592	3	None	-34	3	Mouse	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of mouse D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	71722291	109237	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397385	109237	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040059	109237	0	None	-4	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	146025708	180303	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4531083	180303	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	25142456	89181	2	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	CHEMBL217299	89181	2	None	3	2	Human	7.5	pEC50	=	7.5	Functional	Activity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP productionActivity at human dopamine D1 receptor expressed in HEK293 cells assessed as stimulation of cAMP production	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
	146025708	180303	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4531083	180303	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	409	5	0	6	5.7	Cc1cc(N(CC2CC2)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44276404	105854	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL28054	105854	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	10802235	20031	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL1191487	20031	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL542593	20031	0	None	-	1	Goldfish	5.5	pEC50	=	5.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
	10732044	91188	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2114440	91188	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL2219804	91188	0	None	-	1	Goldfish	7.5	pEC50	=	7.5	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	75201901	173204	19	None	95	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4277264	173204	19	None	95	4	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
	44554474	113062	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099227	113062	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139043	113062	0	None	-301	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	3	1.7	C=CCN1CCO[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155519631	177184	0	None	-15	2	Rat	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to controlPositive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to control	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	CHEMBL4448100	177184	0	None	-15	2	Rat	6.5	pEC50	=	6.5	Functional	Positive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to controlPositive allosteric modulation of rat D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation relative to control	ChEMBL	421	2	1	1	6.9	Cc1cccc(Cl)c1NC(=O)C1(C)CC2c3ccccc3C1c1cc(Cl)ccc12	10.1021/acs.jmedchem.8b01767
	146025818	176541	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4438800	176541	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	44320076	213205	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87910	213205	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	681	8247	72	None	-77	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	940	8247	72	None	-77	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	947	8247	72	None	-77	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	CHEMBL59	8247	72	None	-77	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	DB00988	8247	72	None	-77	14	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2007.06.036
	146025706	178403	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465592	178403	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	681	8247	72	None	-1380	14	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	940	8247	72	None	-1380	14	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	947	8247	72	None	-1380	14	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	CHEMBL59	8247	72	None	-1380	14	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	DB00988	8247	72	None	-1380	14	Rat	5.5	pEC50	=	5.5	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00390a009
	146025818	176541	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4438800	176541	0	None	3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	429	2	0	5	4.1	CC(=O)Oc1c(Br)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025706	178403	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4465592	178403	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	383	4	0	6	5.3	CCN(c1ccc(-c2c(C)ncc3nccn23)c(C)c1)c1nccc2occc12	10.1021/acs.jmedchem.9b00351
	44555137	111041	0	None	-28	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099232	111041	0	None	-28	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	155537335	179091	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	388	2	1	6	3.2	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1nccc2occc12	10.1021/acsmedchemlett.9b00050
	CHEMBL4475239	179091	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	388	2	1	6	3.2	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1nccc2occc12	10.1021/acsmedchemlett.9b00050
	681	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	940	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	947	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	CHEMBL59	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	DB00988	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2011.07.057
	44320002	113818	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315535	113818	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44276556	106478	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL284644	106478	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	146025814	179558	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	179558	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	6852376	98374	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL1467585	98374	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL24077	98374	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	CHEMBL503958	98374	13	None	-1	4	Human	6.4	pEC50	=	6.4	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
	1242	10385	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	935	10385	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	CHEMBL286080	10385	27	None	1	3	Human	6.4	pEC50	=	6.4	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
	146025814	179558	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	179558	0	None	6	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	10540201	107005	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL288536	107005	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
	681	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	940	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	947	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	CHEMBL59	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	DB00988	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.11.012
	44320267	212991	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86576	212991	0	None	-1	2	Rat	7.4	pEC50	=	7.4	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44555138	111042	0	None	-117	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099233	111042	0	None	-117	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	403	5	1	5	3.9	CCCN1C[C@@H](Cn2ccc(-c3ccccc3)n2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	49866139	23024	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CO2	10.1016/j.bmc.2010.07.052
	CHEMBL1224452	23024	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human D1 receptor assessed as cAMP accumulationAgonist activity at human D1 receptor assessed as cAMP accumulation	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@H]1CO2	10.1016/j.bmc.2010.07.052
	1218	10388	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	938	10388	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	CHEMBL353335	10388	30	None	-177	4	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
	44554987	111045	0	None	-114	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099239	111045	0	None	-114	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	13720694	19744	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1189465	19744	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL538785	19744	1	None	-	1	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	325	3	3	4	3.3	C=CCN1CCc2c(cc(O)c(O)c2C)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	13720690	19862	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1190300	19862	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL540575	19862	0	None	-1	2	Rat	6.4	pEC50	=	6.4	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	311	3	3	4	3.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	155521159	177310	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	374	2	1	6	2.9	Cc1c(-c2ccc3c(c2)CCN3c2nccc3occc23)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	CHEMBL4449782	177310	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	374	2	1	6	2.9	Cc1c(-c2ccc3c(c2)CCN3c2nccc3occc23)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	6917970	10463	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	8370	10463	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	CHEMBL487387	10463	61	None	-2454	3	Rat	4.4	pEC50	=	4.4	Functional	Agonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activityAgonist activity at D1 receptor in rat striatum assessed as synaptosomal adenylate cyclase activity	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
	90134304	173293	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
	CHEMBL4278861	173293	1	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
	85090339	189084	0	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	CHEMBL4784143	189084	0	None	-8	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
	10518837	107249	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL290842	107249	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
	76284418	189097	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4784295	189097	0	None	-1	2	Human	7.4	pEC50	=	7.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
	85090320	189342	0	None	-10	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	CHEMBL4787728	189342	0	None	-10	2	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
	53494980	73268	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822918	73268	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852340	73268	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	281	0	3	3	2.7	Oc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	10830234	107153	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL289867	107153	0	None	-	1	Goldfish	7.4	pEC50	=	7.4	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	681	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	940	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	947	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	CHEMBL59	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	DB00988	8247	72	None	-77	14	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
	86302251	179634	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	448	4	1	5	3.5	CN(Cc1nc2cc(Br)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	CHEMBL4514994	179634	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	448	4	1	5	3.5	CN(Cc1nc2cc(Br)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	155549423	180592	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	349	3	2	7	2.3	Cc1c(-c2ccc(Nc3nccc4occc34)nc2)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	CHEMBL4538358	180592	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	349	3	2	7	2.3	Cc1c(-c2ccc(Nc3nccc4occc34)nc2)n(C)c(=O)[nH]c1=O	10.1021/acsmedchemlett.9b00050
	44320327	170203	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL419680	170203	0	None	-1	2	Human	7.3	pEC50	=	7.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	85470885	181439	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	438	4	1	5	3.8	CN(Cc1nc2cc(C(F)(F)F)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	CHEMBL4558647	181439	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assayPositive allosteric modulation of human D1R expressed in CHO cells assessed as 2-fold increase in dopamine-induced cAMP accumulation preincubated for 10 mins followed by dopamine addition and measured after 20 mins by fluorescence assay	ChEMBL	438	4	1	5	3.8	CN(Cc1nc2cc(C(F)(F)F)ccc2[nH]1)C(=O)Cn1c(=O)oc2ccc(Cl)cc21	10.1021/acs.jmedchem.8b01767
	10081286	105550	2	None	1	2	Rat	5.3	pEC50	=	5.3	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effectDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effect	ChEMBL	192	2	3	3	0.4	NCCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	CHEMBL278188	105550	2	None	1	2	Rat	5.3	pEC50	=	5.3	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effectDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes. Partial agonist, maximum effect 59% of dopamine maximum effect	ChEMBL	192	2	3	3	0.4	NCCc1ccc(O)c2c1CC(=O)N2	10.1021/jm00390a009
	10588326	165645	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL40950	165645	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
	10831251	169952	0	None	-	1	Goldfish	6.3	pEC50	=	6.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL41809	169952	0	None	-	1	Goldfish	6.3	pEC50	=	6.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	13864380	213211	1	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL87958	213211	1	None	5	2	Human	6.3	pEC50	=	6.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
	13864381	215123	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL542683	215123	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL99361	215123	3	None	5	3	Human	6.3	pEC50	=	6.3	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
	44331310	114143	1	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9502100
	CHEMBL317741	114143	1	None	-	1	Rat	6.3	pEC50	=	6.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9502100
	168291403	198785	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	281	4	1	3	2.3	NS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	CHEMBL5201584	198785	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	281	4	1	3	2.3	NS(=O)(=O)c1ccc(-c2ccccc2OCF)cc1	10.1021/acs.jmedchem.2c00949
	71563084	94346	0	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335736	94346	0	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	64638	112918	2	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313530	112918	2	None	1	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	6603703	6996	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	9637	6996	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	CHEMBL291143	6996	10	None	-1	4	Rat	8.3	pEC50	=	8.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm9502100
	44320001	212795	0	None	3	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84983	212795	0	None	3	2	Human	8.3	pEC50	=	8.3	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	86764103	139215	13	None	2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	CHEMBL3697578	139215	13	None	2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
	6453963	78314	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	CHEMBL1950491	78314	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	CHEMBL1962947	78314	9	None	10000	2	Human	8.3	pEC50	=	8.3	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmcl.2012.01.005
	130442590	176578	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4439333	176578	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	130442590	176578	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4439333	176578	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
	44320026	212878	0	None	131	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85689	212878	0	None	131	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	117720272	125592	3	None	18	3	Human	8.2	pEC50	=	8.2	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL3421730	125592	3	None	18	3	Human	8.2	pEC50	=	8.2	Functional	Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assayPositive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTRF assay	ChEMBL	421	4	2	3	4.3	C[C@H]1c2cccc(C(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
	10851849	176712	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	CHEMBL44414	176712	0	None	-	1	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
	13720686	18332	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL1180562	18332	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	CHEMBL131313	18332	0	None	3	2	Rat	7.3	pEC50	=	7.3	Functional	Dopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclaseDopamine agonist (Dopamine receptor D1) activity was measured as increase in cAMP formation relative to maximum increase in dopamine-sensitive adenylate cyclase	ChEMBL	389	3	3	4	3.7	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccc(O)cc2)C1	10.1021/jm00384a006
	681	8247	72	None	-1380	14	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	940	8247	72	None	-1380	14	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	947	8247	72	None	-1380	14	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	CHEMBL59	8247	72	None	-1380	14	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	DB00988	8247	72	None	-1380	14	Rat	5.3	pEC50	=	5.3	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9502100
	146025816	176757	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	176757	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	146025816	176757	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4442011	176757	0	None	-2	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	9796958	153356	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115374	153356	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL39230	153356	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL544814	153356	0	None	4	2	Goldfish	7.3	pEC50	=	7.3	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	228	7233	28	None	-14	19	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	33	7233	28	None	-14	19	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	6005	7233	28	None	-14	19	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	CHEMBL53	7233	28	None	-14	19	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	DB00714	7233	28	None	-14	19	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP productionAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as stimulation of cAMP production	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2007.06.036
	44320053	212552	0	None	-3	2	Rat	7.3	pEC50	=	7.3	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL82899	212552	0	None	-3	2	Rat	7.3	pEC50	=	7.3	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	146025720	179727	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4517022	179727	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025720	179727	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4517022	179727	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	341	3	0	5	5.2	Cc1cc(-c2cccc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025700	182151	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4574838	182151	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	146192953	178389	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1ccc(F)cc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4465386	178389	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	413	4	2	3	3.9	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1ccc(F)cc1Cl	10.1021/acsmedchemlett.9b00547
	145992269	173732	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4287192	173732	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
	146025700	182151	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	CHEMBL4574838	182151	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	370	3	0	6	5.3	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)c(C)c1C	10.1021/acs.jmedchem.9b00351
	85090335	187893	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	CHEMBL4760355	187893	0	None	1	2	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
	6852376	98374	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1467585	98374	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL24077	98374	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	CHEMBL503958	98374	13	None	-1	4	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2011.07.057
	145867041	181308	4	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	CHEMBL4555682	181308	4	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Positive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulationPositive allosteric modulation of human D1R expressed in HEK cells assessed as increase in dopamine-induced cAMP accumulation	ChEMBL	421	2	1	1	6.9	Cc1ccc(Cl)c(NC(=O)C2(C)CC3c4ccccc4C2c2ccccc23)c1Cl	10.1021/acs.jmedchem.8b01767
	1153	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	12668023	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	30026874	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	30026875	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	3341	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	6603851	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	933	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	939	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	985	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL1160786	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL1161520	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	CHEMBL588	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	DB00800	8409	58	None	-6	12	Rat	7.2	pEC50	=	7.2	Functional	Dopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranesDopamine receptor D1 agonist efficacy was measured with stimulation of dopamine-sensitive rat adenylate cyclase in caudate membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00390a009
	53494976	73374	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822919	73374	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852625	73374	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	283	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3OC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	155560177	181709	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	378	3	1	6	2.7	Cc1nc2c(c(Oc3ccc(-c4c(C)c(=O)[nH]c(=O)n4C)c(C)c3)n1)CCC2	10.1021/acsmedchemlett.9b00050
	CHEMBL4565185	181709	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	378	3	1	6	2.7	Cc1nc2c(c(Oc3ccc(-c4c(C)c(=O)[nH]c(=O)n4C)c(C)c3)n1)CCC2	10.1021/acsmedchemlett.9b00050
	53494978	73276	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1822920	73276	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	CHEMBL1852349	73276	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	299	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3ccccc3SC[C@@H]1NCC2	10.1016/j.bmc.2011.07.057
	44320129	174673	0	None	56	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL431220	174673	0	None	56	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	44319976	113740	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
	CHEMBL315005	113740	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
	44320378	212842	0	None	63	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL85409	212842	0	None	63	2	Human	8.2	pEC50	=	8.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10015860	106053	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL281932	106053	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	12170	10682	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	137364063	10682	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	CHEMBL5172089	10682	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Positive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assayPositive allosteric modulation of human D1R expressed in SK-N-MC cells assessed as inhibition of DA-induced cAMP production pretreated with compound for 15 mins followed by dopamine EC70 addition measured after 15 mins by HTRF assay	ChEMBL	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	10.1021/acs.jmedchem.2c00949
	146025699	177266	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4449153	177266	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	146025710	176895	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4443737	176895	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025699	177266	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	CHEMBL4449153	177266	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	356	3	0	6	4.9	Cc1cc(-c2c(C)ncc3nccn23)ccc1Oc1nccc2occc12	10.1021/acs.jmedchem.9b00351
	155534541	178752	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	380	4	2	6	2.5	CC(=O)Nc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	10.1021/acsmedchemlett.9b00050
	CHEMBL4470808	178752	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	380	4	2	6	2.5	CC(=O)Nc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	10.1021/acsmedchemlett.9b00050
	146025710	176895	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4443737	176895	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	396	4	0	6	5.8	Cc1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	10506	9302	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	86290953	9302	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	CHEMBL3421729	9302	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Positive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at mouse D1 receptor transiently expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	10.1021/acs.jmedchem.9b01234
	44276405	106885	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
	CHEMBL287513	106885	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
	130442514	173311	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
	CHEMBL4279267	173311	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
	10666423	169081	0	None	-	1	Goldfish	6.2	pEC50	=	6.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	363	1	3	4	4.7	Cc1cccc(-c2cc3c(s2)CN[C@H]2CCc4cc(O)c(O)cc4[C@H]32)c1	10.1021/jm970038v
	CHEMBL416435	169081	0	None	-	1	Goldfish	6.2	pEC50	=	6.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	363	1	3	4	4.7	Cc1cccc(-c2cc3c(s2)CN[C@H]2CCc4cc(O)c(O)cc4[C@H]32)c1	10.1021/jm970038v
	146025719	177986	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4459395	177986	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025719	177986	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4459395	177986	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	399	4	0	6	5.2	Cc1cc(Oc2cc(N3CCCCC3)ccn2)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44319915	212744	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL84557	212744	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	146025726	177546	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4452764	177546	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025823	176356	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	CHEMBL4435882	176356	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	1242	10385	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	935	10385	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	CHEMBL286080	10385	27	None	1	3	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 minsAgonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as increase in cAMP accumulation measured after 30 mins	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2019.04.014
	146025823	176356	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	CHEMBL4435882	176356	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
	146025726	177546	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4452764	177546	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	405	3	0	4	6.4	FC(F)(F)c1cc(Oc2nccc3ccccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	44320123	113860	0	None	4	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	CHEMBL315849	113860	0	None	4	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
	15696487	170578	1	None	97	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL420604	170578	1	None	97	2	Human	7.2	pEC50	=	7.2	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10758745	107209	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115373	107209	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL290438	107209	0	None	-	1	Goldfish	7.2	pEC50	=	7.2	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	14809027	113806	0	None	-3	3	Rat	8.2	pEC50	=	8.2	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL315468	113806	0	None	-3	3	Rat	8.2	pEC50	=	8.2	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	6603820	102549	19	None	1	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2011.07.057
	CHEMBL25856	102549	19	None	1	7	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2011.07.057
	146025728	182792	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4589664	182792	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025728	182792	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4589664	182792	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	394	3	0	5	5.5	FC(F)(F)c1cc(Oc2nccn3cccc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	6604005	163896	2	None	1	4	Rat	6.2	pEC50	=	6.2	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm9502100
	CHEMBL407489	163896	2	None	1	4	Rat	6.2	pEC50	=	6.2	Functional	Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activityEffective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm9502100
	133642	178730	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL4470553	178730	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	133642	178730	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	CHEMBL4470553	178730	10	None	-9	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
	44554986	113061	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099236	113061	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3139041	113061	0	None	-35	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	361	4	1	5	2.9	CCCN1C[C@H](Cn2cc(Cl)cn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	71722301	109250	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	CHEMBL3040157	109250	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	CHEMBL3216146	109250	0	None	-4	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
	130442508	177862	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	CHEMBL4457399	177862	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	71563082	94056	0	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2331599	94056	0	None	-5	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	86293768	125593	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	CHEMBL3421836	125593	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assayPositive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP accumulation incubated for 60 mins by HTRF assay	ChEMBL	435	5	2	3	4.4	C[C@H]1c2cccc(CC(C)(C)O)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.9b01234
	10664137	169534	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL417164	169534	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	130442508	177862	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	CHEMBL4457399	177862	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	346	4	0	5	5.3	COc1ccc(-c2ccc(Oc3nccc4occc34)cc2C)c(C)n1	10.1021/acs.jmedchem.9b00351
	146025725	178328	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4464545	178328	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	146025725	178328	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4464545	178328	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	435	4	0	5	6.8	FC(F)(F)c1cc(Oc2nccc3occ(C4CC4)c23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
	71722295	109244	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL2397381	109244	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	CHEMBL3040115	109244	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 minsAgonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
	10546132	168034	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL41196	168034	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
	146025711	179811	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4518891	179811	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	146025711	179811	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4518891	179811	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2cccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	71562964	94350	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	CHEMBL2335740	94350	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamineAgonist activity at dopamine D1 receptor (unknown origin) transfected in CHO cell membranes assessed as increase in cAMP level after 8 mins by flash plate assay in presence of dopamine	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
	6603703	6996	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	9637	6996	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	CHEMBL291143	6996	10	None	-2	4	Goldfish	8.1	pEC50	=	8.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
	64638	112918	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL313530	112918	2	None	-1	2	Rat	8.1	pEC50	=	8.1	Functional	Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumInhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatum	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	44276551	104151	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL26965	104151	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	44276552	106656	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL285924	106656	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	10497993	175253	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL43514	175253	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
	44276572	103423	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	CHEMBL26365	103423	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
	75201961	176409	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
	CHEMBL4437012	176409	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
	146192955	178305	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	409	4	1	4	3.8	C[C@H]1c2cccc(-c3cnn(C)c3)c2C[C@H](CO)N1C(=O)Cc1ccccc1Cl	10.1021/acsmedchemlett.9b00547
	CHEMBL4464215	178305	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assayPositive allosteric modulation of human D1 receptor expressed in HEK293 assessed as cAMP production incubated for 60 mins by HTRF assay	ChEMBL	409	4	1	4	3.8	C[C@H]1c2cccc(-c3cnn(C)c3)c2C[C@H](CO)N1C(=O)Cc1ccccc1Cl	10.1021/acsmedchemlett.9b00547
	10519436	17998	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL1178784	17998	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	CHEMBL41238	17998	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
	118445551	174094	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
	CHEMBL4294009	174094	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
	13851595	181284	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3098131	181284	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL455497	181284	2	None	-489	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	245	2	1	2	3.0	CCCN1CCC[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	85090338	187540	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	CHEMBL4756163	187540	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in HEK293 cells assessed as potentiation of dopamine-induced cAMP accumulation by measuring dopamine EC50 at 50 uM measured after 30 mins by HitHunter assay (Rvb = 214 nM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
	14809026	212566	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
	CHEMBL83080	212566	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Formation of cAMP on Dopamine receptor D1 in vitro in carp retinaFormation of cAMP on Dopamine receptor D1 in vitro in carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
	14809026	212566	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL83080	212566	3	None	-2	2	Human	5.1	pEC50	=	5.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	10684714	107086	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL2115372	107086	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL289283	107086	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	146025817	182796	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	182796	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025817	182796	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4589737	182796	0	None	66	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	6603820	102549	19	None	-6	7	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
	CHEMBL25856	102549	19	None	-6	7	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
	10592479	107041	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	CHEMBL288846	107041	0	None	-	1	Goldfish	7.1	pEC50	=	7.1	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
	146025705	177393	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4450916	177393	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	44554982	111039	0	None	-58	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	CHEMBL3099230	111039	0	None	-58	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 minsAgonist activity at human recombinant dopamine D1 receptor expressed in CHO cells assessed as cAMP production after 20 mins	ChEMBL	327	4	1	5	2.2	CCCN1C[C@H](Cn2cccn2)O[C@@H]2Cc3c(O)cccc3C[C@H]21	10.1016/j.bmc.2013.11.012
	44320257	212954	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	CHEMBL86325	212954	0	None	2	2	Human	7.1	pEC50	=	7.1	Functional	Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaConcentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
	146025705	177393	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	CHEMBL4450916	177393	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assayAgonist activity at recombinant human D1 receptor expressed in HEK29T cells assessed as induction of stimulatory G-protein-mediated cAMP accumulation measured after 15 mins by Glosensor-based FLIPR assay	ChEMBL	369	3	0	6	4.9	Cc1cc(N(C)c2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
	90142280	174075	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	CHEMBL4293757	174075	1	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assayAgonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as induction of cAMP levels after 30 mins by HTRF assay	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
	9841398	106295	4	None	2	3	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	CHEMBL28338	106295	4	None	2	3	Human	8.1	pEC50	=	8.1	Functional	Potency in adenylate cyclase functional assay against Dopamine receptor D1Potency in adenylate cyclase functional assay against Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
	10546131	107185	0	None	-	1	Goldfish	7.0	pEC50	=	7.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
	CHEMBL290149	107185	0	None	-	1	Goldfish	7.0	pEC50	=	7.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
	6852376	98374	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL1467585	98374	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL24077	98374	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	CHEMBL503958	98374	13	None	-16	4	Goldfish	6.0	pEC50	=	6.0	Functional	Ability to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissueAbility to stimulate the Dopamine receptor D1 like was assayed by measuring cAMP production in cell free homogenates of goldfish retinal tissue	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
	155558060	181463	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	414	4	1	6	3.0	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1ncccc1OC(F)F	10.1021/acsmedchemlett.9b00050
	CHEMBL4559240	181463	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on cAMP accumulation incubated for 10 mins by Gs-cAMP Glosensor assay	ChEMBL	414	4	1	6	3.0	Cc1c(-c2c(C)c(=O)[nH]c(=O)n2C)ccc2c1CCN2c1ncccc1OC(F)F	10.1021/acsmedchemlett.9b00050
	146025822	180570	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4537900	180570	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025822	180570	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4537900	180570	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAgonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	393	3	0	5	4.4	CC(=O)Oc1c(C(C)C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	107930	8311	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	3304	8311	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	CHEMBL298406	8311	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	DB12273	8311	26	None	10471	2	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127305
	3036864	209533	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL1256645	209533	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL1814790	209533	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	CHEMBL62	209533	19	None	-6	6	Human	8.8	pIC50	=	8.8	Functional	Antagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulationAntagonist activity at human recombinant at D1 receptor assessed as inhibition of dopamine-induced cAMP accumulation	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
	155561845	182497	0	None	-5	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4582377	182497	0	None	-5	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	15061351	93254	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	367	2	0	6	3.0	COc1ccc2c(c1OC(C)=O)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL2314734	93254	0	None	-2	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	367	2	0	6	3.0	COc1ccc2c(c1OC(C)=O)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	71453989	90303	0	None	-1	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	298	0	0	4	4.0	Cn1c2cnc1OCC/C=C\CCCCOc1ccccc1-2	10.1021/jm1012374
	CHEMBL2203622	90303	0	None	-1	2	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at dopamine D1 receptorAntagonist activity at dopamine D1 receptor	ChEMBL	298	0	0	4	4.0	Cn1c2cnc1OCC/C=C\CCCCOc1ccccc1-2	10.1021/jm1012374
	70682088	82843	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057446	82843	0	None	-	1	Human	4.9	pIC50	=	4.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	46931072	208824	1	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL608530	208824	1	None	-1	2	Human	5.9	pIC50	=	5.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	3246545	209253	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL1573438	209253	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL611207	209253	1	None	-3	3	Human	6.9	pIC50	=	6.9	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	70690500	82848	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057455	82848	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	155538443	179161	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4476383	179161	0	None	-2	2	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.bmc.2019.04.014
	146025811	178540	0	None	-416	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4467483	178540	0	None	-416	2	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	1353	8692	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3559	8692	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	86	8692	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	CHEMBL54	8692	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	DB00502	8692	93	None	-107	39	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	72301	192897	76	None	-3	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL487182	192897	76	None	-3	2	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2019.04.014
	44299467	204335	0	None	-30	2	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	CHEMBL57029	204335	0	None	-30	2	Rat	5.8	pIC50	=	5.8	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	3246443	44460	2	None	-16	3	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	CHEMBL1457510	44460	2	None	-16	3	Human	4.8	pIC50	=	4.8	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
	44537919	204915	0	None	-60	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL574700	204915	0	None	-60	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	72699716	121967	0	None	-12	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	CHEMBL3344459	121967	0	None	-12	3	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
	161665	179364	35	None	-28	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	CHEMBL448891	179364	35	None	-28	3	Human	4.7	pIC50	=	4.7	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
	70690498	82842	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	CHEMBL2057445	82842	0	None	-	1	Human	4.6	pIC50	=	4.6	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
	13869636	108482	0	None	-83	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	397	8	0	4	4.7	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1021/jm00393a037
	CHEMBL299471	108482	0	None	-83	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	397	8	0	4	4.7	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1021/jm00393a037
	44299213	107409	0	None	-77	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@@H]1C	10.1021/jm00393a037
	CHEMBL292006	107409	0	None	-77	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@@H]1C	10.1021/jm00393a037
	44299579	204498	0	None	-33	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	CHEMBL57140	204498	0	None	-33	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	355	6	1	3	4.0	C[C@@H]1CN(CCCC(=O)c2ccc(F)cc2)CCC1(O)c1ccccc1	10.1021/jm00393a037
	18367	201722	30	None	-60	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	341	6	1	3	3.8	O=C(CCCN1CCC(O)(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	CHEMBL54206	201722	30	None	-60	2	Rat	5.6	pIC50	=	5.6	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	341	6	1	3	3.8	O=C(CCCN1CCC(O)(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	3036864	209533	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL1256645	209533	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL1814790	209533	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	CHEMBL62	209533	19	None	-6	6	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2019.04.014
	3036864	209533	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL1256645	209533	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL1814790	209533	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	CHEMBL62	209533	19	None	-6	6	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2014.09.024
	44299566	203557	0	None	-67	2	Rat	5.5	pIC50	=	5.5	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@H]1C	10.1021/jm00393a037
	CHEMBL56547	203557	0	None	-67	2	Rat	5.5	pIC50	=	5.5	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	411	8	0	4	5.0	CCC(=O)OC1(c2ccccc2)CCN(CCCC(=O)c2ccc(F)cc2)C[C@H]1C	10.1021/jm00393a037
	44537925	205523	0	None	-162	3	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	CHEMBL582945	205523	0	None	-162	3	Human	4.5	pIC50	=	4.5	Functional	Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393Antagonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay in presence of SKF-38393	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
	129103318	174093	0	None	-39	6	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assayAntagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	CHEMBL4293999	174093	0	None	-39	6	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assayAntagonist activity at human dopamine D1 receptor expressed in HEK293T cells assessed as inhibition of dopamine-induced cAMP accumulation preincubated for 15 mins followed by dopamine induction and measured after 30 mins by HTRF assay	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
	228	7233	28	None	-131	19	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	33	7233	28	None	-131	19	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	6005	7233	28	None	-131	19	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	CHEMBL53	7233	28	None	-131	19	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	DB00714	7233	28	None	-131	19	Rat	6.4	pIC50	=	6.4	Functional	Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.Affinity of the Compound for Dopamine D1 receptor in rat striatal membrane was determined in vitro using Dopamine Antagonist [3H]SCH-23390 as ligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(00)80249-8
	146025812	181670	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4564103	181670	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025812	181670	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4564103	181670	0	None	-1	2	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	90899701	176514	0	None	-5	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	313	1	3	5	2.5	COc1ccc2c(c1O)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	CHEMBL4438471	176514	0	None	-5	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	313	1	3	5	2.5	COc1ccc2c(c1O)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	453215	93256	8	None	7	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)C1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL2314745	93256	8	None	7	2	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)C1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2019.04.014
	3246545	209253	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL1573438	209253	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	CHEMBL611207	209253	1	None	-3	3	Human	6.3	pIC50	=	6.3	Functional	Antagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assayAntagonism of D1 dopamine receptor of human was determined in C6D1 low-density cells by using cyclic AMP assay	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
	146025813	182366	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	182366	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	146025813	182366	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4579687	182366	0	None	-2	2	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	3036864	209533	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1256645	209533	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL1814790	209533	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	CHEMBL62	209533	19	None	-6	6	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assayAntagonist activity at dopamine D1 receptor assessed as inhibition of [35S]GTPgammaS binding in cell-based assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
	1353	8692	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3559	8692	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	86	8692	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	CHEMBL54	8692	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	DB00502	8692	93	None	-107	39	Rat	6.3	pIC50	=	6.3	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00393a037
	3036864	209533	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1256645	209533	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1814790	209533	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL62	209533	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	3036864	209533	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1256645	209533	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL1814790	209533	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	CHEMBL62	209533	19	None	-6	6	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
	72699817	121966	0	None	1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	CHEMBL3344458	121966	0	None	1	3	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393Antagonist activity at D1 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assay in presence of SKF38393	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
	5018	10322	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	943	10322	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	946	10322	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	CHEMBL13668	10322	13	None	-42	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assayAntagonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as inhibition of [35S]GTPgammaS binding by scintillation proximity assay	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
	12269810	93257	8	None	-15	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	327	2	2	5	2.8	COc1ccc2c(c1OC)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	CHEMBL2314747	93257	8	None	-15	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	327	2	2	5	2.8	COc1ccc2c(c1OC)CN1CCc3cc(O)c(O)cc3C1C2	10.1016/j.bmc.2019.04.014
	24837531	181553	1	None	-4	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	311	2	1	4	3.1	COc1cc2c(cc1OC)C1Cc3ccc(O)cc3CN1CC2	10.1016/j.bmc.2019.04.014
	CHEMBL4561303	181553	1	None	-4	2	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	311	2	1	4	3.1	COc1cc2c(cc1OC)C1Cc3ccc(O)cc3CN1CC2	10.1016/j.bmc.2019.04.014
	9549058	179929	0	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.bmc.2019.04.014
	CHEMBL4521450	179929	0	None	3	2	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.bmc.2019.04.014
	146025814	179558	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	179558	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	155552483	180838	0	None	-6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	2	1	6	2.8	COc1cc2c(c(OC)c1O)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	CHEMBL4544045	180838	0	None	-6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 minsAntagonist activity at D1 receptor (unknown origin) expressed in CHOK1 cells assessed as inhibition of SKF38393-induced cAMP accumulation measured after 30 mins	ChEMBL	355	2	1	6	2.8	COc1cc2c(c(OC)c1O)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2019.04.014
	146025814	179558	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	CHEMBL4513262	179558	0	None	6	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
	13869644	204031	0	None	-109	2	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	325	6	0	2	4.7	O=C(CCCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	CHEMBL56843	204031	0	None	-109	2	Rat	5.1	pIC50	=	5.1	Functional	Inhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activityInhibitory concentration against rat striatal dopamine (D1) sensitive adenylate cyclase activity	ChEMBL	325	6	0	2	4.7	O=C(CCCN1CCC(c2ccccc2)CC1)c1ccc(F)cc1	10.1021/jm00393a037
	146025815	176558	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	176558	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	146025815	176558	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	CHEMBL4439029	176558	0	None	-33	2	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assayAntagonist activity at D1R (unknown origin) transfected in human HEK293T cells assessed as increase in cAMP accumulation incubated for 2 hrs by cAMP Glo-sensor assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
	156017431	184556	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	CHEMBL4643069	184556	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assayAntagonist activity at human dopamine D1 receptor expressed in CHO-K1 cells by cAMP Hunter assay	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
	11681599	81948	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL203637	81948	0	None	-	0	Human	9.3	pKi	=	9.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
	133538	10391	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	8443	10391	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	CHEMBL574558	10391	24	None	-	1	Human	8.9	pKi	=	8.9	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
	11558055	79927	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL1204122	79927	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL201170	79927	1	None	-	0	Human	8.9	pKi	=	8.9	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11573628	81474	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	CHEMBL203047	81474	0	None	-	0	Human	8.0	pKi	=	8.0	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
	9992499	80161	0	None	-	0	Human	6.0	pKi	=	6	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	CHEMBL201483	80161	0	None	-	0	Human	6.0	pKi	=	6	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
	11716449	147993	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	CHEMBL382850	147993	0	None	-	0	Human	6.8	pKi	=	6.8	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
	10071501	16651	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	CHEMBL114228	16651	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
	1242	10385	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	935	10385	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	CHEMBL286080	10385	27	None	1	3	Human	6.7	pKi	=	6.7	Functional	Agonist activity at dopamine D1 receptorAgonist activity at dopamine D1 receptor	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
	11716438	147660	1	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	CHEMBL382010	147660	1	None	-	0	Human	8.6	pKi	=	8.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
	16090814	88356	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL216258	88356	0	None	-	0	Human	8.6	pKi	=	8.6	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	11566745	81469	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL1202298	81469	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	CHEMBL203029	81469	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
	11558247	82197	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	CHEMBL204098	82197	0	None	-	0	Human	7.7	pKi	=	7.7	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
	11637457	79862	1	None	-	0	Human	6.7	pKi	=	6.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	CHEMBL201093	79862	1	None	-	0	Human	6.7	pKi	=	6.7	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
	9952858	14326	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	CHEMBL108764	14326	0	None	-	0	Rat	7.7	pKi	=	7.7	Functional	Dopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudateDopamine receptor D1 antagonistic activity as ability to block dopamine-stimulated adenylate cyclase in rat caudate	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
	44408818	146943	1	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	CHEMBL380330	146943	1	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
	11573806	82191	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	CHEMBL204065	82191	0	None	-	0	Human	7.6	pKi	=	7.6	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
	10467946	55243	4	None	-	0	Human	8.5	pKi	=	8.5	Functional	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1016/j.ejmech.2022.114378
	CHEMBL155596	55243	4	None	-	0	Human	8.5	pKi	=	8.5	Functional	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1016/j.ejmech.2022.114378
	11623343	147620	1	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	CHEMBL381936	147620	1	None	-	0	Human	8.5	pKi	=	8.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
	11493746	148101	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	CHEMBL383451	148101	0	None	-	0	Human	8.4	pKi	=	8.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
	16090821	88608	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	CHEMBL216439	88608	0	None	-	0	Human	6.5	pKi	=	6.5	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
	11718008	82066	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL203734	82066	0	None	-	0	Human	7.5	pKi	=	7.5	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	137284323	191632	0	None	-	1	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	341	1	1	3	4.9	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CC1	10.1016/j.bmcl.2021.127911
	CHEMBL4852403	191632	0	None	-	1	Human	7.5	pKi	=	7.5	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	341	1	1	3	4.9	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CC1	10.1016/j.bmcl.2021.127911
	11536995	146333	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL379662	146333	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	147230103	186932	0	None	-	2	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2021.127911
	CHEMBL4748915	186932	0	None	-	2	Human	6.4	pKi	=	6.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2021.127911
	5249956	80170	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	CHEMBL201525	80170	1	None	-	0	Human	7.4	pKi	=	7.4	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
	135398737	7745	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	38	7745	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	722	7745	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	CHEMBL42	7745	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	DB00363	7745	93	None	-112	43	Human	7.4	pKi	=	7.4	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2021.127911
	11500677	147626	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	CHEMBL381946	147626	1	None	-	0	Human	6.3	pKi	=	6.3	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
	147200197	192493	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	317	1	1	3	4.7	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4865663	192493	0	None	-	0	Human	7.2	pKi	=	7.2	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	317	1	1	3	4.7	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	11595240	146966	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	CHEMBL380464	146966	0	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
	11558055	79927	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL1204122	79927	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	CHEMBL201170	79927	1	None	-	0	Human	8.2	pKi	=	8.2	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
	4350931	176092	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	CHEMBL441618	176092	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Activity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assayActivity at human D1 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
	4350931	176092	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	CHEMBL441618	176092	44	None	-	1	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
	11522339	82027	1	None	-	0	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	CHEMBL203689	82027	1	None	-	0	Human	7.2	pKi	=	7.2	Functional	Inhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assayInhibition of D1 dopamine receptor in HEK 293 cells by intracellular calcium assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
	5249952	80183	7	None	-	0	Human	6.1	pKi	=	6.1	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.4	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	10.1021/jm050846j
	CHEMBL201584	80183	7	None	-	0	Human	6.1	pKi	=	6.1	Functional	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by functional calcium assay	ChEMBL	304	1	1	1	4.4	CN1CCc2c([nH]c3ccccc23)CC(c2ccccc2)CC1	10.1021/jm050846j
	135409468	8816	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	333	8816	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	CHEMBL845	8816	69	None	-	5	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	10.1016/j.bmcl.2021.127911
	164623328	192655	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	331	2	1	3	5.0	CCc1ccc2c(c1)C(C1=CCN(C)CC1)=Nc1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4868181	192655	0	None	-	0	Human	7.1	pKi	=	7.1	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	331	2	1	3	5.0	CCc1ccc2c(c1)C(C1=CCN(C)CC1)=Nc1cc(C)ccc1N2	10.1016/j.bmcl.2021.127911
	149505732	193010	0	None	-	1	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	321	1	1	3	4.6	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2021.127911
	CHEMBL4873426	193010	0	None	-	1	Human	7.0	pKi	=	7.0	Functional	Antagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulationAntagonist activity at human D1 receptor expressed in CHO cells assessed as inhibition of dopamine-induced calcium accumulation	ChEMBL	321	1	1	3	4.6	Cc1ccc2c(c1)N=C(C1=CCN(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2021.127911
	1225	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	3958	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	667477	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	CHEMBL860	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	DB01142	8253	26	None	-3	11	Human	8.2	pEC50	=	8.2	Functional	NoneNone	Drug Central	279	3	0	2	4.0	CN(CC/C=C\1/c2ccccc2OCc2c1cccc2)C	None
	133538	10391	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	8443	10391	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	CHEMBL574558	10391	24	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.Biased towards G-protein signalling in a cellular assay expressing only D<sub>1</sub> receptor.	Guide to Pharmacology	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	25660762
	12170	10682	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	137364063	10682	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	CHEMBL5172089	10682	10	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Ligand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamineLigand-induced elevation of cAMP production in the presence of EC<sub>70</sub> dopamine	Guide to Pharmacology	279	4	1	3	3.7	N=S(=O)(c1ccc(c2ccccc2OCF)cc1)C	36044544
	10506	9302	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	86290953	9302	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	CHEMBL3421729	9302	20	None	20	3	Human	8.6	pEC50	=	8.6	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing human D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	10506	9302	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	86290953	9302	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	CHEMBL3421729	9302	20	None	-20	3	Mouse	7.2	pEC50	=	7.2	Functional	Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.Potentiator potency: Increase of cAMP by LY3154207 in the presence of an EC<sub>20</sub> concentration of dopamine in HEK293 cells transiently expressing mouse D<sub>1</sub> receptors.	Guide to Pharmacology	449	6	2	3	4.7	OC[C@H]1Cc2c(cccc2[C@@H](N1C(=O)Cc1c(Cl)cccc1Cl)C)CCC(O)(C)C	31532644
	122324	6993	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	6077	6993	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	CHEMBL86931	6993	22	None	-4	4	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	16318870
	11938	9190	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	146192952	9190	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	CHEMBL4468760	9190	7	None	11	4	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	35175768
	100	10577	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	2637	10577	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	5452	10577	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	CHEMBL479	10577	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
	DB00679	10577	58	None	-7	38	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None

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Ligands (move mouse cursor over ligand name to see structure)					Receptor			Assay information							Chemical information
Sel. page	Similar- ity	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity	# Tested GPCRs	Species	p-value (-log)	Activity Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
		3294	8787	111	None	-56	44	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	8787	111	None	-56	44	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	8787	111	None	-56	44	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	8787	111	None	-56	44	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	8787	111	None	-56	44	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		103	10925	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	10925	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	10925	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	10925	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	10925	61	None	-28	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		46780481	114308	20	None	-29	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		9903970	114308	20	None	-29	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3187365	114308	20	None	-29	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		CHEMBL3544974	114308	20	None	-29	53	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	10.1038/s41467-023-40064-9
		17676	13844	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		5281082	13844	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1085	13844	29	None	-	3	Human	7.0	pAC50	=	7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	411	7	1	6	3.5	CC(=O)c1ccc2c(c1)N(CCCN1CCN(CCO)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		2105	9828	37	None	-123	32	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	9828	37	None	-123	32	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	9828	37	None	-123	32	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	9828	37	None	-123	32	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	9828	37	None	-123	32	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL508338	195745	0	None	-	6	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		6237	93579	46	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
		CHEMBL232201	93579	46	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	518	3	1	3	5.1	CCc1oc2ccccc2c1C(=O)c1cc(I)c(O)c(I)c1	10.1038/s41467-023-40064-9
		2237	9936	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		3634	9936	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		4887	9936	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		CHEMBL21333	9936	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		DB01411	9936	79	None	-	3	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		60663	182448	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1421212	182448	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL1534525	182448	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		CHEMBL45816	182448	42	None	-	0	Human	5.0	pAC50	=	5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	11	1	5	5.3	COCC(=O)O[C@]1(CCN(C)CCCc2nc3ccccc3[nH]2)CCc2cc(F)ccc2[C@@H]1C(C)C	10.1038/s41467-023-40064-9
		1613	9127	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	9127	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	9127	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	9127	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	9127	53	None	-5	44	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		2993	121470	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL121663	121470	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL333826	121470	24	None	-	0	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	456	11	2	2	6.2	Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]1c(C)cc(N)c2ccccc21	10.1038/s41467-023-40064-9
		7099	202301	59	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		CHEMBL55400	202301	59	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	209	0	2	3	2.6	Nc1ccc2cc3ccc(N)cc3nc2c1	10.1038/s41467-023-40064-9
		4151	10379	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		493	10379	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		5312125	10379	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL24778	10379	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		DB06207	10379	89	None	-	3	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	495	13	3	6	3.1	OCCCN1CCc2c1c(cc(c2)C[C@H](NCCOc1ccccc1OCC(F)(F)F)C)C(=O)N	10.1038/s41467-023-40064-9
		2284	9956	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		4926	9956	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		7281	9956	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL564	9956	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00420	9956	33	None	-36	29	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	10.1038/s41467-023-40064-9
		1830	9368	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		207	9368	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		23897	9368	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		CHEMBL460	9368	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		DB01618	9368	44	None	-	28	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1038/s41467-023-40064-9
		2520	210787	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL1280	210787	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL6966	210787	70	None	-	12	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	454	13	0	6	5.1	COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC	10.1038/s41467-023-40064-9
		2865	10915	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	10915	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	10915	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	10915	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	10915	73	None	-114	53	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		5354	162435	21	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		CHEMBL404849	162435	21	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	337	12	2	3	5.6	CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1	10.1038/s41467-023-40064-9
		82146	11302	113	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
		CHEMBL1023	11302	113	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	348	3	1	1	6.1	C=C(c1ccc(C(=O)O)cc1)c1cc2c(cc1C)C(C)(C)CCC2(C)C	10.1038/s41467-023-40064-9
		27901	84982	22	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL2105458	84982	22	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	286	4	0	3	3.8	CN1CCC(N(Cc2cccs2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		7019	174755	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1308088	174755	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL43184	174755	106	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	194	0	1	2	3.0	Nc1c2ccccc2nc2ccccc12	10.1038/s41467-023-40064-9
		133	9274	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		1723	9274	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		28693	9274	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		CHEMBL19215	9274	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		DB13520	9274	52	None	-30	43	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	10.1038/s41467-023-40064-9
		213046	9164	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	9164	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	9164	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	9164	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	9164	59	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		1577	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		2537	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5355	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5501	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		643497	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		688272	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		958	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		960	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL196677	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL26	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL267044	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB00391	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB16021	10475	110	None	-537	20	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		3652	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		57	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		60809	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		CHEMBL21536	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		DB15357	10869	79	None	-	18	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	7	0	5	3.2	CCCCCCOc1nsnc1C1=CCCN(C1)C	10.1038/s41467-023-40064-9
		72287	67835	38	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1764	67835	38	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	328	5	0	4	4.5	COc1ccc2c(c1)N(C[C@H](C)CN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		237	211644	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL546257	211644	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL554190	211644	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		CHEMBL7568	211644	48	None	-	13	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	9	1	4	6.0	CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12	10.1038/s41467-023-40064-9
		1027	8357	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		3241	8357	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		7176	8357	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL1106	8357	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB00751	8357	73	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	249	0	2	1	2.7	N=C1NCC2N1c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		3055	8215	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		313	8215	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		7163	8215	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL936	8215	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		DB01231	8215	44	None	-	9	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.2	OC(c1ccccc1)(c1ccccc1)CCCN1CCCCC1	10.1038/s41467-023-40064-9
		213	10625	55	None	-12	43	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		2717	10625	55	None	-12	43	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		5533	10625	55	None	-12	43	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL621	10625	55	None	-12	43	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB00656	10625	55	None	-12	43	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	10.1038/s41467-023-40064-9
		2337	10030	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	10030	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	10030	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	10030	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	10030	77	None	-53	62	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		2406	107180	89	None	-	12	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
		CHEMBL290106	107180	89	None	-	12	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	2	2	3	5.9	Oc1c(Cl)cc(Cl)cc1Sc1cc(Cl)cc(Cl)c1O	10.1038/s41467-023-40064-9
		214	10632	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		2740	10632	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		5566	10632	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		66064	10632	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL422	10632	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00831	10632	58	None	-	30	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		9417	140290	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	140290	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	140290	54	None	-	0	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		47979	84985	59	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL2105581	84985	59	None	-	0	Human	7.9	pAC50	=	7.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	8	2	6	0.7	C=CCN1CCCC1CNC(=O)c1cc(S(N)(=O)=O)cc(OC)c1OC	10.1038/s41467-023-40064-9
		9429	208912	58	None	-	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL609109	208912	58	None	-	4	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	0	6	3.2	CN1CCN(CCCN2c3ccccc3Sc3ccc(S(=O)(=O)N(C)C)cc32)CC1	10.1038/s41467-023-40064-9
		213046	9164	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		4168	9164	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		7461	9164	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		CHEMBL1237021	9164	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		DB08815	9164	59	None	-	9	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	492	5	0	6	4.3	O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1	10.1038/s41467-023-40064-9
		60860	212418	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		CHEMBL1615777	212418	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		CHEMBL818	212418	30	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	275	2	3	1	1.3	N=C(N)NCc1cccc(I)c1	10.1038/s41467-023-40064-9
		2749	7132	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		5574	7132	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7237	7132	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL829	7132	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01246	7132	40	None	-	2	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	298	4	0	3	4.5	CN(CC(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		26987	7736	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		6063	7736	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		671	7736	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		CHEMBL1626	7736	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		DB00283	7736	33	None	-245	21	Human	5.9	pAC50	=	5.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	10.1038/s41467-023-40064-9
		3166	176199	23	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		CHEMBL442444	176199	23	None	-	0	Human	4.9	pAC50	=	4.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	317	8	0	3	4.2	CCN(CC)CCOC(=O)C(c1ccccc1)C1CCCCC1	10.1038/s41467-023-40064-9
		135398745	9688	112	None	-26	65	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	9688	112	None	-26	65	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	9688	112	None	-26	65	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	9688	112	None	-26	65	Human	6.9	pAC50	=	6.9	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		2398	7741	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2801	7741	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		701	7741	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL415	7741	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB01242	7741	62	None	-11	29	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		9419	42696	35	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1442422	42696	35	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	295	3	0	3	3.0	CN(C)CCN1C(=O)c2ccccc2N(C)c2ccccc21	10.1038/s41467-023-40064-9
		6726	8063	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7151	8063	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		749	8063	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL648	8063	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB01176	8063	51	None	-	13	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	266	3	0	2	3.0	CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		16960	21259	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1201287	21259	23	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CC[C@@H](c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		5584	209990	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL644	209990	44	None	-	1	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	294	4	0	2	4.1	CC(CN(C)C)CN1c2ccccc2CCc2ccccc21	10.1038/s41467-023-40064-9
		9853053	127297	74	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		CHEMBL354541	127297	74	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	693	10	2	3	8.4	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	10.1038/s41467-023-40064-9
		1765	10589	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		4184	10589	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		9871419	10589	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		CHEMBL398435	10589	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		DB08816	10589	98	None	-	1	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	522	10	4	11	2.0	CCCSc1nc(N[C@@H]2C[C@H]2c2ccc(c(c2)F)F)c2c(n1)n(nn2)[C@@H]1C[C@@H]([C@H]([C@H]1O)O)OCCO	10.1038/s41467-023-40064-9
		54454	12030	88	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
		CHEMBL1064	12030	88	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	418	6	1	5	4.6	CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@H]21	10.1038/s41467-023-40064-9
		12488	8438	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		941361	8438	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		CHEMBL30008	8438	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		DB04841	8438	56	None	-19	23	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	10.1038/s41467-023-40064-9
		68802	116812	37	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
		CHEMBL32350	116812	37	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	226	0	1	2	2.9	Cc1ccc2c(c1)c1c3n2CCNC3CCC1	10.1038/s41467-023-40064-9
		49843517	85069	41	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
		CHEMBL2107831	85069	41	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
		3606	210267	60	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL6615	210267	60	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	270	5	2	2	4.8	CCC(c1ccc(O)cc1)C(CC)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		135	9310	43	None	-91	56	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	9310	43	None	-91	56	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	9310	43	None	-91	56	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	9310	43	None	-91	56	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	9310	43	None	-91	56	Human	6.8	pAC50	=	6.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		10219	195575	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		CHEMBL493439	195575	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		CHEMBL50588	195575	37	None	-	5	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	480	7	1	6	4.9	CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]1NCCc2cc(OC)c(OC)cc21	10.1038/s41467-023-40064-9
		134	9292	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1775	9292	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		9681	9292	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		CHEMBL1065	9292	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		DB00247	9292	24	None	-263	67	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	10.1038/s41467-023-40064-9
		1890	9535	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		4449	9535	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		7247	9535	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		CHEMBL623	9535	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		DB01149	9535	49	None	-	16	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	10.1038/s41467-023-40064-9
		5489013	64179	32	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
		CHEMBL1651913	64179	32	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	8	2	4	3.0	COc1cccc(C(=O)CCN[C@@H](C)[C@H](O)c2ccccc2)c1	10.1038/s41467-023-40064-9
		115358	108339	38	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	463	9	2	6	5.9	COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1	10.1038/s41467-023-40064-9
		CHEMBL298470	108339	38	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	463	9	2	6	5.9	COc1cc(C)c2c(Oc3cccc(C(F)(F)F)c3)c(OC)cc(NC(C)CCCN)c2n1	10.1038/s41467-023-40064-9
		1577	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		2537	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5355	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		5501	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		643497	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		688272	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		958	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		960	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL196677	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL26	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		CHEMBL267044	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB00391	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		DB16021	10475	110	None	-537	20	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1038/s41467-023-40064-9
		2162	48288	100	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1491	48288	100	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL508338	195745	0	None	-	6	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		5568	204279	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		66069	204279	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL1201102	204279	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		CHEMBL570	204279	29	None	-	5	Human	7.8	pAC50	=	7.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	10.1038/s41467-023-40064-9
		71277	91314	27	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	789	9	4	15	2.7	CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C	10.1038/s41467-023-40064-9
		CHEMBL2220427	91314	27	None	-	0	Human	4.8	pAC50	=	4.8	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	789	9	4	15	2.7	CCC(=O)O[C@H]1[C@H](O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)O[C@H](C)C[C@@H]1N(C)C	10.1038/s41467-023-40064-9
		2286	9957	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	9957	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	9957	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	9957	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	9957	51	None	-30	30	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		22323	22071	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9571037	22071	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1213553	22071	32	None	-	0	Human	5.8	pAC50	=	5.8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	2	5	2	2.9	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		2146	9874	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		485	9874	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6041	9874	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL1215	9874	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		DB00388	9874	67	None	-	9	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	167	3	3	3	0.6	CNC[C@@H](c1cccc(c1)O)O	10.1038/s41467-023-40064-9
		6834	212331	45	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL811	212331	45	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	5	0	2	3.9	CN(C)CCC(c1ccc(Br)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		191	7191	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		201	7191	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		2170	7191	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		CHEMBL1113	7191	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		DB00543	7191	98	None	-26	29	Human	6.7	pAC50	=	6.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	10.1038/s41467-023-40064-9
		1909	9598	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		2559	9598	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		4474	9598	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL1484	9598	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		CHEMBL3302409	9598	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		DB00622	9598	64	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	479	9	1	8	3.7	COC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OCCN(Cc1ccccc1)C)C	10.1038/s41467-023-40064-9
		212	10578	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	10578	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	10578	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	10578	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	10578	47	None	-6	25	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2335	18620	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	18620	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	18620	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	18620	22	None	-	12	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		25025298	84926	39	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
		CHEMBL2103855	84926	39	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
		103	10925	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		2875	10925	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		5736	10925	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL285802	10925	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB09225	10925	61	None	-28	53	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		3601	21275	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1201349	21275	9	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	502	9	0	0	8.2	C[N+](C)(CCCCCC[N+](C)(C)C1c2ccccc2-c2ccccc21)C1c2ccccc2-c2ccccc21	10.1038/s41467-023-40064-9
		2762	10635	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5587	10635	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		7318	10635	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		CHEMBL1241	10635	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		DB00792	10635	31	None	-	2	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	255	6	0	3	2.7	CN(CCN(c1ccccn1)Cc1ccccc1)C	10.1038/s41467-023-40064-9
		5583	19816	51	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL119	19816	51	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	369	6	3	8	2.7	COc1cc(NCc2ccc3nc(N)nc(N)c3c2C)cc(OC)c1OC	10.1038/s41467-023-40064-9
		22530	62904	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1600878	62904	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		CHEMBL1625607	62904	58	None	-	3	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	276	2	0	2	3.7	CN1CCc2c(c3ccccc3n2Cc2ccccc2)C1	10.1038/s41467-023-40064-9
		62867	9903	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		7557	9903	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL398880	9903	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01621	9903	35	None	-	2	Human	7.7	pAC50	=	7.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	475	8	1	6	4.0	OCCC1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		9822750	85184	65	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
		CHEMBL2111097	85184	65	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	408	8	2	7	2.3	CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)[C@@H]1c1ccccc1Cl	10.1038/s41467-023-40064-9
		25151352	147384	67	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		CHEMBL3813873	147384	67	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		1547484	7727	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		654	7727	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		9072	7727	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL43064	7727	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00568	7727	74	None	-	20	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	368	6	0	2	5.1	c1ccc(cc1)/C=C/CN1CCN(CC1)C(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4167	21272	43	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL1201342	21272	43	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	2	0	2	5.0	CN1CCCC(CC2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		40973	52809	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
		CHEMBL1533	52809	70	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	1	1	1	4.9	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CCCC[C@@H]4[C@H]3C(=C)C[C@@]21CC	10.1038/s41467-023-40064-9
		4418	40996	85	None	-	7	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		CHEMBL142635	40996	85	None	-	7	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	392	7	1	5	3.4	COc1ccccc1N1CCN(CC(O)COc2cccc3ccccc23)CC1	10.1038/s41467-023-40064-9
		3344	205097	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		CHEMBL576127	205097	57	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	260	3	1	3	1.8	O=C1NCC2(CCN(CCc3ccccc3)CC2)O1	10.1038/s41467-023-40064-9
		242	7258	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-281	51	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		9601226	109177	7	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	563	14	1	6	6.1	CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)O)C(C)C	10.1038/s41467-023-40064-9
		CHEMBL3039598	109177	7	None	-	0	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	563	14	1	6	6.1	CCC(=O)O[C@@H](O[P@](=O)(CCCCc1ccccc1)CC(=O)N1C[C@H](C2CCCCC2)C[C@H]1C(=O)O)C(C)C	10.1038/s41467-023-40064-9
		138106885	173690	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
		36314	173690	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
		CHEMBL428647	173690	75	None	-	4	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	853	10	4	14	3.7	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	10.1038/s41467-023-40064-9
		3336	101776	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1405922	101776	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL254832	101776	30	None	-	1	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	7	1	1	5.6	CC(NCCC(c1ccccc1)c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		4601	213526	35	None	-	17	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1201023	213526	35	None	-	17	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL900	213526	35	None	-	17	Human	4.7	pAC50	=	4.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	269	6	0	2	3.7	Cc1ccccc1C(OCCN(C)C)c1ccccc1	10.1038/s41467-023-40064-9
		102	10899	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		3659	10899	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		8969	10899	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL15245	10899	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		DB01392	10899	48	None	-25118	49	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	10.1038/s41467-023-40064-9
		25295	20392	37	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1194287	20392	37	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	289	6	0	3	3.3	CN(C)CCN(Cc1ccc(Cl)cc1)c1ccccn1	10.1038/s41467-023-40064-9
		9417	140290	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL1524185	140290	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL370753	140290	54	None	-	0	Human	5.7	pAC50	=	5.7	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	363	6	1	4	3.3	OCCN1CCN(CCCN2c3ccccc3C=Cc3ccccc32)CC1	10.1038/s41467-023-40064-9
		11057	182928	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		3468	182928	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL459265	182928	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL64894	182928	23	None	-2	20	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	10.1038/s41467-023-40064-9
		2585	7590	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		522	7590	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		551	7590	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		CHEMBL723	7590	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		DB01136	7590	103	None	-112	22	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	10.1038/s41467-023-40064-9
		3117	214620	103	None	-2	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
		CHEMBL964	214620	103	None	-2	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	10.1038/s41467-023-40064-9
		1599	9120	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		3955	9120	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		7215	9120	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL841	9120	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		DB00836	9120	50	None	-	16	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	476	7	1	3	5.1	Clc1ccc(cc1)C1(O)CCN(CC1)CCC(C(=O)N(C)C)(c1ccccc1)c1ccccc1	10.1038/s41467-023-40064-9
		135398737	7745	93	None	-44	90	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	7745	93	None	-44	90	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	7745	93	None	-44	90	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	7745	93	None	-44	90	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	7745	93	None	-44	90	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		16564	211774	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
		CHEMBL76725	211774	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	207	2	3	3	0.3	N=C(N)NCC1COc2ccccc2O1	10.1038/s41467-023-40064-9
		4417	62336	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL1439099	62336	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL1620794	62336	54	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	10	0	4	4.5	CCN(CC)CCOC(=O)C(Cc1cccc2ccccc12)CC1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL4744444	220813	32	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]1C(=O)NCC(=O)N[C@@H](CCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@H](CO)C(=O)N[C@@H]([C@H](C)CC(=O)O)C(=O)N[C@@H](CC(=O)c2ccccc2N)C(=O)O[C@@H]1C	10.1038/s41467-023-40064-9
		31101	7516	40	None	-436	35	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		35	7516	40	None	-436	35	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		403	7516	40	None	-436	35	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		CHEMBL493	7516	40	None	-436	35	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		DB01200	7516	40	None	-436	35	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	10.1038/s41467-023-40064-9
		1613	9127	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		205	9127	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3964	9127	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		CHEMBL831	9127	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		DB00408	9127	53	None	-5	44	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	10.1038/s41467-023-40064-9
		3627	50903	18	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1515447	50903	18	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	3	0	2	4.1	CN1CCCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		93154	12208	29	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		CHEMBL107360	12208	29	None	-	0	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	1	0	2	4.0	c1ccc2c(c1)CCc1ccccc1N2C1CN2CCC1CC2	10.1038/s41467-023-40064-9
		16222096	87258	67	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
		CHEMBL2146883	87258	67	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	4	3	4	3.8	O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1	10.1038/s41467-023-40064-9
		1227	9267	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		2331	9267	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		3957	9267	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		4992	9267	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL511	9267	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		DB06691	9267	43	None	-	12	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	285	7	0	4	2.7	COc1ccc(cc1)CN(c1ccccn1)CCN(C)C	10.1038/s41467-023-40064-9
		5022	8432	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		6918248	8432	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		8182	8432	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL231068	8432	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		DB04908	8432	76	None	-	9	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	4	1	4	3.2	O=c1[nH]c2c(n1CCN1CCN(CC1)c1cccc(c1)C(F)(F)F)cccc2	10.1038/s41467-023-40064-9
		6077	157477	31	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL39560	157477	31	None	-	0	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		3561	25849	39	None	-1	11	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL1289	25849	39	None	-1	11	Human	5.6	pAC50	=	5.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	10.1038/s41467-023-40064-9
		441383	27105	57	None	-12	17	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1306	27105	57	None	-12	17	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	10.1038/s41467-023-40064-9
		259329	67278	31	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	519	7	2	4	5.3	C[C@]12CC[C@@H]3c4ccc(OC(=O)N(CCCl)CCCl)cc4CC[C@H]3[C@@H]1CC[C@@H]2OP(=O)(O)O	10.1038/s41467-023-40064-9
		CHEMBL1756	67278	31	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	519	7	2	4	5.3	C[C@]12CC[C@@H]3c4ccc(OC(=O)N(CCCl)CCCl)cc4CC[C@H]3[C@@H]1CC[C@@H]2OP(=O)(O)O	10.1038/s41467-023-40064-9
		2181	9902	46	None	-	34	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		4830	9902	46	None	-	34	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		92	9902	46	None	-	34	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL440294	9902	46	None	-	34	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		DB09286	9902	46	None	-	34	Human	6.6	pAC50	=	6.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	10.1038/s41467-023-40064-9
		CHEMBL5291995	201315	0	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	341	5	0	5	3.3	CN(C)CCCN1C(=O)c2cc([N+](=O)[O-])ccc2Oc2ccccc21	10.1038/s41467-023-40064-9
		4098	39279	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1255739	39279	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL1411979	39279	30	None	-	11	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	6	0	4	2.7	CN(C)CCN(Cc1cccs1)c1ccccn1	10.1038/s41467-023-40064-9
		1153	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		12668023	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026874	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026875	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		3341	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		6603851	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		933	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		939	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		985	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1160786	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1161520	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL588	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		DB00800	8409	58	None	-32	10	Human	7.6	pAC50	=	7.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		4485	76154	118	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
		CHEMBL193	76154	118	None	-	8	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	346	4	1	7	2.2	COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1ccccc1[N+](=O)[O-]	10.1038/s41467-023-40064-9
		1190	7669	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		25074887	7669	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		583	7669	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		CHEMBL1200490	7669	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		DB00050	7669	47	None	-	1	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL		None	None	None		None	10.1038/s41467-023-40064-9
		48041	113858	46	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
		CHEMBL315838	113858	46	None	-	0	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	352	6	1	3	4.4	COc1ccc(C(=O)Nc2ccccc2CCC2CCCCN2C)cc1	10.1038/s41467-023-40064-9
		40	8329	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		77993	8329	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		995	8329	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL1510	8329	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		DB00216	8329	58	None	-	5	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	382	6	1	3	3.8	CN1CCC[C@@H]1Cc1c[nH]c2c1cc(cc2)CCS(=O)(=O)c1ccccc1	10.1038/s41467-023-40064-9
		37464	25993	26	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
		CHEMBL1290	25993	26	None	-	4	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	291	6	2	3	3.5	CC(C)(C)NC[C@H](O)COc1ccccc1C1CCCC1	10.1038/s41467-023-40064-9
		3584	10549	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		5401	10549	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		7302	10549	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		CHEMBL611	10549	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		DB01162	10549	64	None	-	14	Human	4.6	pAC50	=	4.6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	387	4	2	7	0.9	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1CCCO1	10.1038/s41467-023-40064-9
		3158	63041	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	63041	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		2237	9936	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		3634	9936	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		4887	9936	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		CHEMBL21333	9936	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		DB01411	9936	79	None	-	3	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	481	9	2	7	4.6	O=C(c1ccc(cc1)OCCCCc1ccccc1)Nc1cccc2c1oc(cc2=O)c1[nH]nnn1	10.1038/s41467-023-40064-9
		25025298	84926	39	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
		CHEMBL2103855	84926	39	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	546	8	3	8	4.5	Cc1ccn(-c2cc(Cl)ccc2[C@@H](Oc2cc(-c3ccc(C[C@H](N)C(=O)O)cc3)nc(N)n2)C(F)(F)F)n1	10.1038/s41467-023-40064-9
		228	7233	28	None	-35	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		33	7233	28	None	-35	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		6005	7233	28	None	-35	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		CHEMBL53	7233	28	None	-35	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		DB00714	7233	28	None	-35	23	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1038/s41467-023-40064-9
		9571107	174298	33	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		CHEMBL430	174298	33	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		2600	10551	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	10551	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	10551	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	10551	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	10551	74	None	-7	13	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		150311	16584	102	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	409	6	2	3	4.9	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	10.1038/s41467-023-40064-9
		CHEMBL1138	16584	102	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	409	6	2	3	4.9	O=C1[C@H](CC[C@H](O)c2ccc(F)cc2)[C@@H](c2ccc(O)cc2)N1c1ccc(F)cc1	10.1038/s41467-023-40064-9
		2444	21250	26	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		CHEMBL1201245	21250	26	None	-	2	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	333	6	0	2	4.1	CN(C)CCOC(c1ccccc1)c1ccc(Br)cc1	10.1038/s41467-023-40064-9
		2799	46568	55	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	364	4	1	1	7.0	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1476605	46568	55	None	-	0	Human	4.5	pAC50	=	4.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	364	4	1	1	7.0	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1	10.1038/s41467-023-40064-9
		11154555	7587	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		5037	7587	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		7671	7587	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL2028019	7587	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL3085826	7587	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB06016	7587	62	None	-1445	12	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		11976	7707	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		667467	7707	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		CHEMBL908	7707	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		DB01239	7707	59	None	-12	24	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1038/s41467-023-40064-9
		2865	10915	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	10915	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	10915	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	10915	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	10915	73	None	-114	53	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL4743867	220812	14	None	-	0	Human	8.5	pAC50	=	8.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL		None	None	None		OCCN1CCN(CCC=C2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	10.1038/s41467-023-40064-9
		3158	63041	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		CHEMBL1628227	63041	27	None	-2398	20	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	10.1038/s41467-023-40064-9
		277	8083	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		2913	8083	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		765	8083	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		CHEMBL516	8083	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		DB00434	8083	62	None	-33	50	Human	7.5	pAC50	=	7.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	10.1038/s41467-023-40064-9
		1427	8794	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		357	8794	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		3696	8794	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL11	8794	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00458	8794	54	None	-977	27	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		15387	52596	55	None	-	24	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1531134	52596	55	None	-	24	Human	6.5	pAC50	=	6.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	5	0	2	3.5	CC1CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1038/s41467-023-40064-9
		2286	9957	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		4927	9957	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		7282	9957	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		CHEMBL643	9957	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		DB01069	9957	51	None	-30	30	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	10.1038/s41467-023-40064-9
		124087	8171	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		7157	8171	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		814	8171	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		CHEMBL1172	8171	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		DB00967	8171	114	None	-	15	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	0	1	2	4.0	Clc1ccc2c(c1)CCc1c(C2=C2CCNCC2)nccc1	10.1038/s41467-023-40064-9
		2105	9828	37	None	-123	32	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		47811	9828	37	None	-123	32	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		48	9828	37	None	-123	32	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		CHEMBL531	9828	37	None	-123	32	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		DB01186	9828	37	None	-123	32	Human	5.5	pAC50	=	5.5	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1038/s41467-023-40064-9
		9571107	174298	33	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		CHEMBL430	174298	33	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	389	5	2	8	1.0	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN	10.1038/s41467-023-40064-9
		3678	101567	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL253371	101567	57	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	9	0	1	4.6	CCN(CCCc1ccccc1)CCCc1ccccc1	10.1038/s41467-023-40064-9
		2335	18620	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		8478	18620	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL1182210	18620	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL221753	18620	22	None	-	12	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	11	0	2	6.1	CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1	10.1038/s41467-023-40064-9
		54758501	145845	58	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		CHEMBL3786343	145845	58	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	486	7	2	8	5.1	C=CC(=O)Nc1cccc(Oc2nc(Nc3ccc(N4CCN(C)CC4)cc3)nc3ccsc23)c1	10.1038/s41467-023-40064-9
		71109	84981	10	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
		CHEMBL2105453	84981	10	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	272	4	1	4	2.9	OC(CN1CCCCC1)c1cc(-c2ccccc2)on1	10.1038/s41467-023-40064-9
		1971	9641	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		2404	9641	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		4543	9641	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL445	9641	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		DB00540	9641	38	None	-8	30	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	10.1038/s41467-023-40064-9
		2389	10104	118	None	-489	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	10104	118	None	-489	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	10104	118	None	-489	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	10104	118	None	-489	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	10104	118	None	-489	66	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		2771	201796	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	201796	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	201796	74	None	-120	27	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		34040	34858	72	None	-	1	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		CHEMBL1372950	34858	72	None	-	1	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	483	4	0	6	3.9	CO[C@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]1Cc1cn(C)c3cccc2c13	10.1038/s41467-023-40064-9
		2865	10915	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		59	10915	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		60854	10915	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL708	10915	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		DB00246	10915	73	None	-114	53	Human	8.4	pAC50	=	8.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1038/s41467-023-40064-9
		2601	10552	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		443951	10552	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		56	10552	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		CHEMBL73151	10552	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		DB13399	10552	33	None	-16	21	Human	6.4	pAC50	=	6.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		12555	24733	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL12610	24733	53	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	7	0	4	3.4	CN(C)CCCOc1nn(Cc2ccccc2)c2ccccc12	10.1038/s41467-023-40064-9
		11167602	77235	116	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
		CHEMBL1946170	77235	116	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
		1548955	95356	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		2800	95356	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL2355051	95356	20	None	-	18	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	405	9	0	2	6.6	CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		1212	8443	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		204	8443	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		3372	8443	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL726	8443	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00623	8443	50	None	-51	65	Human	7.4	pAC50	=	7.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1038/s41467-023-40064-9
		25102847	84996	93	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
		CHEMBL2105717	84996	93	None	-	0	Human	5.4	pAC50	=	5.4	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	501	8	2	6	5.5	COc1cc2nccc(Oc3ccc(NC(=O)C4(C(=O)Nc5ccc(F)cc5)CC4)cc3)c2cc1OC	10.1038/s41467-023-40064-9
		1588	9105	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		28864	9105	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		43	9105	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		CHEMBL157138	9105	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		DB00589	9105	27	None	-131	44	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1038/s41467-023-40064-9
		135398737	7745	93	None	-44	90	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	7745	93	None	-44	90	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	7745	93	None	-44	90	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	7745	93	None	-44	90	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	7745	93	None	-44	90	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		180	7189	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	7189	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	7189	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	7189	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	7189	56	None	-109	40	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		193962	110570	106	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		CHEMBL308954	110570	106	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	434	4	2	7	4.7	Cc1cc(C#N)cc(C)c1Oc1nc(Nc2ccc(C#N)cc2)nc(N)c1Br	10.1038/s41467-023-40064-9
		1353	8692	93	None	-38	85	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	8692	93	None	-38	85	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	8692	93	None	-38	85	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	8692	93	None	-38	85	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	8692	93	None	-38	85	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3157	8252	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		7170	8252	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		954	8252	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		CHEMBL707	8252	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		DB00590	8252	71	None	-	12	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	4	2	8	1.5	COc1cc2nc([nH]c(=N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2	10.1038/s41467-023-40064-9
		5328940	106992	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		CHEMBL288441	106992	107	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	529	9	1	8	5.2	COc1cc(Nc2c(C#N)cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)c(Cl)cc1Cl	10.1038/s41467-023-40064-9
		135398737	7745	93	None	-44	90	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		38	7745	93	None	-44	90	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		722	7745	93	None	-44	90	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL42	7745	93	None	-44	90	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		DB00363	7745	93	None	-44	90	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1038/s41467-023-40064-9
		65772	67177	8	None	-	6	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
		CHEMBL174984	67177	8	None	-	6	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	345	5	3	6	2.6	COc1cc(C[C@@H]2NCCc3cc(O)c(O)cc32)cc(OC)c1OC	10.1038/s41467-023-40064-9
		5329102	201505	86	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		CHEMBL535	201505	86	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	7	3	3	3.3	CCN(CC)CCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(F)cc32)c1C	10.1038/s41467-023-40064-9
		135	9310	43	None	-91	56	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		1796	9310	43	None	-91	56	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		4184	9310	43	None	-91	56	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		CHEMBL6437	9310	43	None	-91	56	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		DB06148	9310	43	None	-91	56	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1038/s41467-023-40064-9
		2683	109665	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL305906	109665	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		CHEMBL334255	109665	25	None	-	16	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	15	0	0	6.5	CCCCCCCCCCCCCCCC[n+]1ccccc1	10.1038/s41467-023-40064-9
		16362	9899	71	None	-52480	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		2172	9899	71	None	-52480	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		90	9899	71	None	-52480	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL1423	9899	71	None	-52480	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		DB01100	9899	71	None	-52480	29	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	10.1038/s41467-023-40064-9
		5351322	101566	38	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		CHEMBL25336	101566	38	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	398	4	4	8	1.8	C(=N/NC1=NCCN1)\c1c2ccccc2c(/C=N/NC2=NCCN2)c2ccccc12	10.1038/s41467-023-40064-9
		65863	21237	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1201196	21237	57	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	436	6	0	4	7.0	Clc1ccc(C(Cn2ccnc2)OCc2csc3c(Cl)cccc23)c(Cl)c1	10.1038/s41467-023-40064-9
		115368	9830	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		2112	9830	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		7556	9830	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		CHEMBL1472975	9830	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		DB08922	9830	47	None	-	4	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	6	0	6	3.4	O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1CCCC2	10.1038/s41467-023-40064-9
		208898	72973	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		CHEMBL184412	72973	78	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	556	18	1	6	7.0	CCCCc1oc2ccc(NS(C)(=O)=O)cc2c1C(=O)c1ccc(OCCCN(CCCC)CCCC)cc1	10.1038/s41467-023-40064-9
		1086	8371	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		3290	8371	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		7181	8371	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		CHEMBL1206	8371	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		DB00392	8371	27	None	-	2	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	5	0	3	5.0	CCN(C(CN1c2ccccc2Sc2c1cccc2)C)CC	10.1038/s41467-023-40064-9
		2337	10030	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	10030	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	10030	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	10030	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	10030	77	None	-53	62	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		2726	7706	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		621	7706	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		83	7706	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		CHEMBL71	7706	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		DB00477	7706	68	None	-36	72	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1038/s41467-023-40064-9
		448537	167029	89	None	-28	25	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL411	167029	89	None	-28	25	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		10531	8202	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		121	8202	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		888	8202	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		CHEMBL1732	8202	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		DB00320	8202	21	None	-218	24	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	10.1038/s41467-023-40064-9
		4822	51806	47	None	-	1	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL152408	51806	47	None	-	1	Human	7.3	pAC50	=	7.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	293	0	0	2	4.7	CN1CCC(=C2c3ccccc3Sc3ccccc32)CC1	10.1038/s41467-023-40064-9
		2407	10145	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		59227	10145	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		941	10145	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		CHEMBL1303	10145	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		DB05271	10145	76	None	-128	7	Human	6.3	pAC50	=	6.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1038/s41467-023-40064-9
		49843517	85069	41	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
		CHEMBL2107831	85069	41	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	590	13	2	6	8.5	CCCCCCO[C@@H](C)c1cccc(-c2csc(NC(=O)c3cc(Cl)c(/C=C(\C)C(=O)O)c(Cl)c3)n2)c1OC	10.1038/s41467-023-40064-9
		25151352	147384	67	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		CHEMBL3813873	147384	67	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay (CRO assay) measured by scintillation counting	ChEMBL	417	5	2	4	5.2	FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1	10.1038/s41467-023-40064-9
		11167602	77235	116	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
		CHEMBL1946170	77235	116	None	-	0	Human	5.3	pAC50	=	5.3	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	482	5	3	4	5.7	CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(C(F)(F)F)c3)c(F)c2)ccn1	10.1038/s41467-023-40064-9
		10071196	9898	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		5142	9898	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		8423	9898	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		CHEMBL2111101	9898	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		DB05316	9898	79	None	-	2	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	8	1	3	4.7	CC(COc1ccc(cc1)CNC(=O)N(C1CCN(CC1)C)Cc1ccc(cc1)F)C	10.1038/s41467-023-40064-9
		71897	85023	19	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
		CHEMBL2106537	85023	19	None	-	0	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	304	4	1	3	2.7	Cc1cc(CCN2CCN(c3cccc(Cl)c3)CC2)n[nH]1	10.1038/s41467-023-40064-9
		2805	168669	38	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL415087	168669	38	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	329	6	0	2	4.9	Clc1ccc(C(OCCN2CCCCC2)c2ccccc2)cc1	10.1038/s41467-023-40064-9
		114948	67071	14	None	-	3	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
		CHEMBL1743263	67071	14	None	-	3	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	577	5	3	6	2.5	CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C[C@@H]4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	10.1038/s41467-023-40064-9
		16351	109507	47	None	-	6	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL304902	109507	47	None	-	6	Human	8.2	pAC50	=	8.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1038/s41467-023-40064-9
		123879	10060	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		1910	10060	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		1911	10060	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		2354	10060	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		CHEMBL361812	10060	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		DB13036	10060	82	None	-	4	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	416	6	2	4	3.1	OC(=O)CCn1c2CC[C@H](Cc2c2c1cccc2)NS(=O)(=O)c1ccc(cc1)F	10.1038/s41467-023-40064-9
		10180	105645	47	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		CHEMBL279014	105645	47	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	6	1	4	4.5	CCN(CC)CCNc1ccc(C)c2sc3ccccc3c(=O)c12	10.1038/s41467-023-40064-9
		3598	194600	76	None	-	7	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
		CHEMBL496	194600	76	None	-	7	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	404	2	2	2	6.6	Oc1c(Cl)cc(Cl)c(Cl)c1Cc1c(O)c(Cl)cc(Cl)c1Cl	10.1038/s41467-023-40064-9
		37	7565	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		460	7565	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		54746	7565	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201087	7565	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		DB00248	7565	60	None	-14	17	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	10.1038/s41467-023-40064-9
		1524	8962	96	None	-79	51	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		197	8962	96	None	-79	51	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		3822	8962	96	None	-79	51	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		88	8962	96	None	-79	51	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		CHEMBL51	8962	96	None	-79	51	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		DB12465	8962	96	None	-79	51	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	10.1038/s41467-023-40064-9
		242	7258	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-281	51	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		21855	91021	42	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		CHEMBL22108	91021	42	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	292	5	0	2	4.1	CC(C1=C(CCN(C)C)Cc2ccccc21)c1ccccn1	10.1038/s41467-023-40064-9
		5353853	24758	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		9556529	24758	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		CHEMBL1262	24758	47	None	-19	15	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	10.1038/s41467-023-40064-9
		2389	10104	118	None	-489	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	10104	118	None	-489	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	10104	118	None	-489	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	10104	118	None	-489	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	10104	118	None	-489	66	Human	6.2	pAC50	=	6.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		6077	157477	31	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL39560	157477	31	None	-	0	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	326	5	0	4	4.4	CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2	10.1038/s41467-023-40064-9
		3294	8787	111	None	-56	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		71360	8787	111	None	-56	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		87	8787	111	None	-56	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		CHEMBL14376	8787	111	None	-56	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		DB04946	8787	111	None	-56	44	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1038/s41467-023-40064-9
		2710	91083	31	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL22150	91083	31	None	-	3	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	300	3	0	2	3.7	CN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1	10.1038/s41467-023-40064-9
		43082	67057	37	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1742452	67057	37	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	357	6	0	2	5.5	CC(OCCN1CCCCCC1)(c1ccccc1)c1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		98941	53724	17	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		CHEMBL154126	53724	17	None	-	0	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	457	7	0	4	6.3	COc1ccc2c(c1)OC(C)(C)C(c1ccccc1)C2c1ccc(OCCN2CCCC2)cc1	10.1038/s41467-023-40064-9
		2107	9829	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		4747	9829	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		9216	9829	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		CHEMBL251940	9829	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		DB01608	9829	50	None	-5	2	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	10.1038/s41467-023-40064-9
		5440	35497	37	None	-1	9	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		CHEMBL1378	35497	37	None	-1	9	Human	8.1	pAC50	=	8.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	10.1038/s41467-023-40064-9
		104903	63118	17	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1630578	63118	17	None	-	6	Human	5.2	pAC50	=	5.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	624	6	0	8	5.5	C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)C3=CC[C@]2(C)[C@H]1C(=O)CN1CCN(c2cc(N3CCCC3)nc(N3CCCC3)n2)CC1	10.1038/s41467-023-40064-9
		1712	9270	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		4078	9270	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		7227	9270	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		CHEMBL1088	9270	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		DB00933	9270	43	None	-6	22	Human	7.2	pAC50	=	7.2	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	10.1038/s41467-023-40064-9
		2771	201796	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL1200781	201796	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		CHEMBL549	201796	74	None	-120	27	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	10.1038/s41467-023-40064-9
		135409453	10545	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	10545	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	10545	41	None	-	2	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		2446	161432	57	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
		CHEMBL399510	161432	57	None	-	1	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	343	7	2	4	2.1	CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC	10.1038/s41467-023-40064-9
		681	8247	72	None	-154	38	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		940	8247	72	None	-154	38	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		947	8247	72	None	-154	38	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		CHEMBL59	8247	72	None	-154	38	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		DB00988	8247	72	None	-154	38	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1038/s41467-023-40064-9
		3103	48432	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		CHEMBL1492	48432	49	None	-	4	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	281	4	0	2	3.9	CN1CCC(OC(c2ccccc2)c2ccccc2)CC1	10.1038/s41467-023-40064-9
		135398745	9688	112	None	-26	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		47	9688	112	None	-26	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL715	9688	112	None	-26	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		DB00334	9688	112	None	-26	65	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1038/s41467-023-40064-9
		212	10578	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		2639	10578	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		941651	10578	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		CHEMBL1201	10578	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		DB01623	10578	47	None	-6	25	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	10.1038/s41467-023-40064-9
		242	7258	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		34	7258	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		60795	7258	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		CHEMBL1112	7258	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		DB01238	7258	124	None	-281	51	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1038/s41467-023-40064-9
		3952	8669	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5353646	8669	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5443	8669	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		5702063	8669	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		CHEMBL1331786	8669	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		CHEMBL420	8669	38	None	-	12	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	230	2	2	2	1.6	NC(=N/N=C\c1c(Cl)cccc1Cl)N	10.1038/s41467-023-40064-9
		2389	10104	118	None	-489	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		5073	10104	118	None	-489	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		96	10104	118	None	-489	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		CHEMBL85	10104	118	None	-489	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		DB00734	10104	118	None	-489	66	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1038/s41467-023-40064-9
		129893322	35391	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		4923	35391	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		5353897	35391	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		6178111	35391	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		CHEMBL1377	35391	56	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	253	2	5	2	2.2	CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1	10.1038/s41467-023-40064-9
		2337	10030	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		50	10030	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		5002	10030	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		CHEMBL716	10030	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		DB01224	10030	77	None	-53	62	Human	6.1	pAC50	=	6.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1038/s41467-023-40064-9
		1209	8439	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		203	8439	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		3386	8439	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		CHEMBL41	8439	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		DB00472	8439	75	None	-	32	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	10.1038/s41467-023-40064-9
		5591	164310	90	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		CHEMBL408	164310	90	None	-	2	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	441	5	2	6	4.4	Cc1c(C)c2c(c(C)c1O)CCC(C)(COc1ccc(CC3SC(=O)NC3=O)cc1)O2	10.1038/s41467-023-40064-9
		3280	55223	28	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
		CHEMBL1555736	55223	28	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	395	10	0	5	5.4	CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC	10.1038/s41467-023-40064-9
		4209	9937	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		4893	9937	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		503	9937	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		5385	9937	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		CHEMBL2	9937	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		DB00457	9937	75	None	-	33	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	10.1038/s41467-023-40064-9
		3053	211913	95	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		CHEMBL780	211913	95	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	393	16	5	8	-2.7	O=C(O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O	10.1038/s41467-023-40064-9
		5205	84962	58	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL2104895	84962	58	None	-	0	Human	7.1	pAC50	=	7.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	261	0	0	1	3.8	CN1CCC2=C(C1)c1ccccc1Cc1ccccc12	10.1038/s41467-023-40064-9
		CHEMBL1630575	63117	0	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	1093	23	16	18	-3.3	CC[C@H](C)C[C@H](C)CCCCCCCCC(=O)N[C@H]1C[C@@H](O)[C@@H](NCCN)NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@H]([C@H](O)CCN)NC(=O)[C@H]([C@H](O)[C@@H](O)c2ccc(O)cc2)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@H]([C@@H](C)O)NC1=O	10.1038/s41467-023-40064-9
		443869	84916	45	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		CHEMBL2103761	84916	45	None	-	0	Human	5.1	pAC50	=	5.1	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	491	7	1	8	3.8	COC(=O)C1=C(C)NC(C)=C(C(=O)O[C@H]2CCN(Cc3ccccc3)C2)[C@H]1c1cccc([N+](=O)[O-])c1	10.1038/s41467-023-40064-9
		1353	8692	93	None	-38	85	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	8692	93	None	-38	85	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	8692	93	None	-38	85	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	8692	93	None	-38	85	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	8692	93	None	-38	85	Human	8.0	pAC50	=	8	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		2600	10551	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		2608	10551	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		5405	10551	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		CHEMBL17157	10551	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		DB00342	10551	74	None	-7	13	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	10.1038/s41467-023-40064-9
		180	7189	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		200	7189	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2160	7189	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		CHEMBL629	7189	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		DB00321	7189	56	None	-109	40	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1038/s41467-023-40064-9
		2580	85170	18	None	-	2	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		CHEMBL2110775	85170	18	None	-	2	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	446	6	1	4	4.1	NC(=O)C1(N2CCCCC2)CCN(CCCN2c3ccccc3CCc3ccccc32)CC1	10.1038/s41467-023-40064-9
		4756	23421	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		CHEMBL1201022	23421	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		CHEMBL1242	23421	50	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	213	2	2	5	2.7	Nc1ccc(/N=N/c2ccccc2)c(N)n1	10.1038/s41467-023-40064-9
		1153	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		12668023	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026874	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		30026875	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		3341	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		6603851	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		933	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		939	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		985	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1160786	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL1161520	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		CHEMBL588	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		DB00800	8409	58	None	-32	10	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1038/s41467-023-40064-9
		1353	8692	93	None	-38	85	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		3559	8692	93	None	-38	85	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		86	8692	93	None	-38	85	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		CHEMBL54	8692	93	None	-38	85	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		DB00502	8692	93	None	-38	85	Human	7.0	pAC50	=	7.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1038/s41467-023-40064-9
		135409453	10545	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		226	10545	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		CHEMBL76370	10545	41	None	-	2	Human	6.0	pAC50	=	6.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	3	2.6	CCCCCN=C(N/N=C/c1c[nH]c2c1cc(OC)cc2)N	10.1038/s41467-023-40064-9
		3783	20777	23	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		CHEMBL1197051	20777	23	None	-	0	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	301	7	3	4	2.9	CC(COc1ccccc1)NC(C)C(O)c1ccc(O)cc1	10.1038/s41467-023-40064-9
		6075	156887	42	None	-	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		CHEMBL395110	156887	42	None	-	16	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	310	2	0	3	4.6	CN1CCCC(CN2c3ccccc3Sc3ccccc32)C1	10.1038/s41467-023-40064-9
		4735	201894	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL361506	201894	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		CHEMBL55	201894	96	None	-	10	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	340	10	4	4	2.9	N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc1	10.1038/s41467-023-40064-9
		4034	62596	55	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		CHEMBL1623	62596	55	None	-	1	Human	5.0	pAC50	=	5.0	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	390	5	0	2	5.6	Cc1cccc(CN2CCN(C(c3ccccc3)c3ccc(Cl)cc3)CC2)c1	10.1038/s41467-023-40064-9
		2247	7293	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		249	7293	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		2603	7293	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		CHEMBL296419	7293	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		DB00637	7293	81	None	-61	42	Human	6.0	pAC50	=	6	Binding	Binding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation countingBinding affinity towards human DRD1 in an in vitro assay with cellular components (NIBR assay) measured by scintillation counting	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	10.1038/s41467-023-40064-9
		146025821	176450	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4437552	176450	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146025821	176450	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4437552	176450	0	None	-	0	Human	9.4	pEC50	=	9.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	3	0	5	3.9	CCc1cc2c(c(OC(C)=O)c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146025817	182796	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4589737	182796	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146025817	182796	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4589737	182796	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146192964	181489	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL4559891	181489	0	None	-	0	Human	8.0	pEC50	=	8.0	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	469	5	1	4	5.2	C[C@H]1c2cccc(-c3cnn(C4CC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		681	8247	72	None	-154	38	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		940	8247	72	None	-154	38	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		947	8247	72	None	-154	38	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		CHEMBL59	8247	72	None	-154	38	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		DB00988	8247	72	None	-154	38	Human	7.0	pEC50	=	7	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		6852376	98374	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
		CHEMBL1467585	98374	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
		CHEMBL24077	98374	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
		CHEMBL503958	98374	13	None	-4	5	Rat	7.0	pEC50	=	7	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00041a025
		11938	9190	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		146192952	9190	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL4468760	9190	7	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		75201901	173204	19	None	-1	24	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	173204	19	None	-1	24	Human	7.0	pEC50	=	7.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		130442471	182863	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
		CHEMBL4591207	182863	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
		75201961	176409	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
		CHEMBL4437012	176409	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	331	3	0	5	5.0	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnnc1C	10.1021/acsmedchemlett.9b00050
		130442471	182863	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
		CHEMBL4591207	182863	0	None	-	0	Human	6.0	pEC50	=	6.0	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	331	3	1	5	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1cc(N)cnc1C	10.1021/acs.jmedchem.9b00351
		75201901	173204	19	None	-1	24	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	173204	19	None	-1	24	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		4901726	187578	9	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4756486	187578	9	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		12668019	17011	8	None	204	3	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
		CHEMBL1160787	17011	8	None	204	3	Human	7.9	pEC50	=	7.9	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/acs.jmedchem.8b00435
		6603820	102549	19	None	-4	12	Human	7.9	pEC50	=	7.9	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
		CHEMBL25856	102549	19	None	-4	12	Human	7.9	pEC50	=	7.9	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
		146025820	180001	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4523054	180001	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	365	2	0	5	3.6	CC(=O)Oc1c(C)cc2c(c1OC(C)=O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		681	8247	72	None	-154	38	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		940	8247	72	None	-154	38	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		947	8247	72	None	-154	38	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		CHEMBL59	8247	72	None	-154	38	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		DB00988	8247	72	None	-154	38	Human	5.9	pEC50	=	5.9	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acsmedchemlett.9b00050
		85090318	186224	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4740497	186224	0	None	-	0	Human	5.9	pEC50	=	5.9	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	413	3	0	5	4.7	Cc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		146192966	182095	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acs.jmedchem.1c01887
		CHEMBL4573538	182095	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	457	5	1	4	4.9	CCn1cc(-c2cccc3c2C[C@H](CO)N(C(=O)Cc2c(Cl)cccc2Cl)[C@H]3C)cn1	10.1021/acs.jmedchem.1c01887
		85090319	187389	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4754602	187389	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	401	3	0	6	3.9	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		85090338	187540	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4756163	187540	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	389	4	0	6	3.4	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		85090320	189342	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4787728	189342	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		85090337	190060	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4796761	190060	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	433	3	0	5	5.0	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		11938	9190	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		146192952	9190	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL4468760	9190	7	None	-	0	Mouse	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of mouse D1 receptor expressed in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	443	4	1	4	4.4	C[C@H]1c2cccc(c3cn(C)nc3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		85090325	186528	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4744261	186528	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3cccc(Cl)c3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		85090334	187404	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4754761	187404	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	3	0	5	4.4	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(CC3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		132016545	179855	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	333	2	0	1	4.7	C[C@H]1c2ccccc2CCN1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
		CHEMBL4519818	179855	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	333	2	0	1	4.7	C[C@H]1c2ccccc2CCN1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
		9796958	153356	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL2115374	153356	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL39230	153356	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL544814	153356	0	None	-28	4	Human	5.8	pEC50	=	5.8	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		130442473	174116	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4294397	174116	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		130442473	174116	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4294397	174116	0	None	-	1	Human	6.8	pEC50	=	6.8	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		85090335	187893	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
		CHEMBL4760355	187893	0	None	-	0	Human	6.8	pEC50	=	6.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	359	3	0	5	3.4	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccccc1	10.1016/j.bmcl.2020.127696
		85090330	187852	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		CHEMBL4759814	187852	0	None	-	0	Human	5.8	pEC50	=	5.8	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	463	4	0	6	5.0	COc1ccc(-n2c(CC3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		167715	9651	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		969	9651	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		CHEMBL225230	9651	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		24133757	178379	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	340	1	1	2	5.2	CC1c2ccsc2CCN1C(=O)Nc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
		CHEMBL4465320	178379	0	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Positive allosteric modulation of D1R (unknown origin) by HTS assayPositive allosteric modulation of D1R (unknown origin) by HTS assay	ChEMBL	340	1	1	2	5.2	CC1c2ccsc2CCN1C(=O)Nc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.8b01767
		167715	9651	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		969	9651	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		CHEMBL225230	9651	14	None	-194	5	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		133642	178730	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
		CHEMBL4470553	178730	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
		133642	178730	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
		CHEMBL4470553	178730	10	None	-	0	Human	5.7	pEC50	=	5.7	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	307	2	0	3	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/acsmedchemlett.9b00575
		10742	10389	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
		1225	10389	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
		CHEMBL35354	10389	31	None	-2	8	Human	8.7	pEC50	=	8.7	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/acs.jmedchem.8b00435
		10020353	20661	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
		CHEMBL1196161	20661	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
		CHEMBL556024	20661	18	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	343	3	2	3	4.2	C=CCN1CCc2c(cc(O)c(O)c2Cl)C(c2cccc(C)c2)C1	10.1021/acs.jmedchem.8b00435
		85090328	187814	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4759339	187814	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.2	Cc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		146025701	177350	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
		CHEMBL4450338	177350	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
		146025713	178390	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4465393	178390	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		146025701	177350	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
		CHEMBL4450338	177350	0	None	-	0	Human	6.7	pEC50	=	6.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	357	3	1	7	4.2	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1N	10.1021/acs.jmedchem.9b00351
		146025713	178390	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4465393	178390	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	372	3	0	6	5.4	Cc1cc(Oc2nccc3ccsc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		130442480	182049	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	182049	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		130442480	182049	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	182049	0	None	-1	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		146025816	176757	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4442011	176757	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		1242	10385	27	None	-5	17	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
		935	10385	27	None	-5	17	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
		CHEMBL286080	10385	27	None	-5	17	Human	6.6	pEC50	=	6.6	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	nan
		146192967	197891	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	485	5	1	5	4.5	C[C@H]1c2cccc(-c3cnn(C4COC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL5187909	197891	0	None	-	0	Human	7.6	pEC50	=	7.6	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	485	5	1	5	4.5	C[C@H]1c2cccc(-c3cnn(C4COC4)c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		146025816	176757	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4442011	176757	0	None	-	0	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		130442590	176578	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4439333	176578	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
		130442590	176578	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4439333	176578	0	None	-	0	Human	5.6	pEC50	=	5.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)nc2cnccn12	10.1021/acs.jmedchem.9b00351
		130442572	178687	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	178687	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		130442572	178687	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	178687	0	None	-3	24	Human	6.6	pEC50	=	6.6	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		6603703	6996	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		9637	6996	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		CHEMBL291143	6996	10	None	-1	5	Human	8.5	pEC50	=	8.5	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		1153	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		12668023	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		30026874	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		30026875	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		3341	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		6603851	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		933	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		939	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		985	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		CHEMBL1160786	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		CHEMBL1161520	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		CHEMBL588	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		DB00800	8409	58	None	-32	10	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assayAgonist activity at human dopamine D1 receptor expressed in CHOK1 cells assessed as assessed as increase in beta-arrestin-2 recruitment after 60 mins by luminescence assay	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/acs.jmedchem.8b00435
		75201901	173204	19	None	-1	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
		CHEMBL4277264	173204	19	None	-1	24	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acsmedchemlett.9b00050
		2030130	27751	16	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL1311333	27751	16	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	385	2	0	5	4.3	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		85090324	187471	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4755481	187471	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	405	2	0	5	4.5	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		76284418	189097	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4784295	189097	0	None	-	0	Human	6.5	pEC50	=	6.5	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	371	2	0	5	3.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		75202022	177589	2	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		CHEMBL4453318	177589	2	None	-	1	Human	7.5	pEC50	=	7.5	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		146025815	176558	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4439029	176558	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		1218	10388	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		938	10388	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		CHEMBL353335	10388	30	None	-11	8	Human	6.4	pEC50	=	6.4	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		146025815	176558	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4439029	176558	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		85090321	189592	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4790909	189592	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	373	3	0	5	3.7	Cc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		85090323	188701	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4779641	188701	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1ccc(Cl)cc1	10.1016/j.bmcl.2020.127696
		146266	107474	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		CHEMBL292418	107474	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		CHEMBL540857	107474	8	None	-2	4	Human	7.4	pEC50	=	7.4	Binding	Antagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assayAntagonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as inhibition of SKF81297-induced beta arrestin2 recruitment preincubated for 30 mins followed by SKF81297 addition and measured after 90 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		146025823	176356	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
		CHEMBL4435882	176356	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
		146025823	176356	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
		CHEMBL4435882	176356	0	None	-	0	Human	7.4	pEC50	=	7.4	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	457	4	0	6	5.0	COc1cccc(-c2cc3c(c(OC(C)=O)c2OC(C)=O)-c2cccc4c2[C@@H](C3)N(C)CC4)c1	10.1021/acsmedchemlett.9b00575
		85090322	186238	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4740678	186238	0	None	-	0	Human	6.4	pEC50	=	6.4	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	415	3	0	6	4.3	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		75201899	178695	0	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
		CHEMBL4469983	178695	0	None	-	1	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assayAgonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
		228	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		33	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		6005	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		CHEMBL53	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		DB00714	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		3033200	181306	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
		CHEMBL4555547	181306	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
		85090333	188080	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		CHEMBL4762375	188080	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	399	2	0	5	4.6	Cc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1	10.1016/j.bmcl.2020.127696
		85090326	189552	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		CHEMBL4790277	189552	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	423	4	0	6	4.1	COc1ccc(-n2c(CC(C)C)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		228	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		33	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		6005	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		CHEMBL53	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		DB00714	7233	28	None	-35	23	Human	6.3	pEC50	=	6.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/acsmedchemlett.9b00575
		3033200	181306	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
		CHEMBL4555547	181306	5	None	-	0	Human	5.3	pEC50	=	5.3	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	379	4	0	5	4.1	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(OC(C)=O)c(OC(C)=O)c1-3	10.1021/acsmedchemlett.9b00575
		85090332	187498	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		CHEMBL4755709	187498	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	435	3	0	6	4.6	COc1ccc(-n2c(C3CCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		6852376	98374	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL1467585	98374	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL24077	98374	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL503958	98374	13	None	-3	5	Human	7.2	pEC50	=	7.2	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		146192960	178298	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		CHEMBL4464150	178298	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Positive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assayPositive allosteric modulation of human D1 receptor in HEK293 cells assessed as increase in cyclic AMP production measured after 60 mins in presence of dopamine by HTRF assay	ChEMBL	429	4	2	3	4.4	C[C@H]1c2cccc(-c3cn[nH]c3)c2C[C@H](CO)N1C(=O)Cc1c(Cl)cccc1Cl	10.1021/acs.jmedchem.1c01887
		85090339	189084	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
		CHEMBL4784143	189084	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	393	3	0	5	4.1	CC(C)Cc1nc2c(c(=O)c3ccccc3n2C)c(=O)n1-c1cccc(Cl)c1	10.1016/j.bmcl.2020.127696
		136326241	186207	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4740312	186207	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	295	1	1	4	2.4	Cn1c2ccccc2c(=O)c2c(=O)[nH]c(C3CCCC3)nc21	10.1016/j.bmcl.2020.127696
		92044504	178506	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4467080	178506	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		92044504	178506	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4467080	178506	0	None	-	0	Human	6.2	pEC50	=	6.2	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	3	0	6	4.5	Cc1cc(Oc2nccn3cccc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		3045992	182854	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4591021	182854	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		90134269	180985	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4548284	180985	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		90134269	180985	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4548284	180985	1	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Agonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assayAgonist activity at recombinant C-terminal RLuc8-fused human D1 receptor expressed in HEK29T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 15 mins in presence of coelenterazine H by BRET assay	ChEMBL	342	3	1	6	4.5	Nc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		3045992	182854	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4591021	182854	1	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Agonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAgonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	355	6	0	5	3.4	COCOc1ccc2c(c1OCOC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		85090329	189461	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4789255	189461	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	419	2	0	5	4.9	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccc(Cl)cc3)c(C3CCCCC3)nc21	10.1016/j.bmcl.2020.127696
		85090331	188232	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		CHEMBL4764398	188232	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	449	3	0	6	4.9	COc1ccc(-n2c(C3CCCCC3)nc3c(c(=O)c4ccccc4n3C)c2=O)cc1Cl	10.1016/j.bmcl.2020.127696
		76284419	190027	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
		CHEMBL4796389	190027	0	None	-	0	Human	6.1	pEC50	=	6.1	Binding	Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)Positive allosteric modulator activity at human dopamine D1 receptor expressed in CHO-K1 cells assessed as potentiation of dopamine-induced beta-arrestin2 recruitment by measuring dopamine EC50 at 50 uM incubated for 90 mins by PathHunter assay (Rvb = 1.4 uM)	ChEMBL	343	2	0	5	3.1	Cn1c2ccccc2c(=O)c2c(=O)n(-c3ccccc3)c(C3CC3)nc21	10.1016/j.bmcl.2020.127696
		9841398	106295	4	None	-3	4	Human	8.1	pEC50	=	8.1	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
		CHEMBL28338	106295	4	None	-3	4	Human	8.1	pEC50	=	8.1	Binding	Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1Adenylate cyclase assay carried out in LTK cells transfected with human Dopamine receptor D1	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
		1218	10388	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		938	10388	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		CHEMBL353335	10388	30	None	-11	8	Human	5.0	pEC50	=	5.0	Binding	Agonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assayAgonist activity at recombinant human D1 receptor expressed in CHOK1 cells assessed as induction of beta arrestin2 recruitment measured after 30 mins by coelenterazine-based beta-galactosidase reporter gene assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acs.jmedchem.9b00412
		72548703	168346	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		CHEMBL4128926	168346	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysisDisplacement of [3H]-SCH 23390 from human recombinant dopamine D1 receptor after 60 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
		3036864	209533	19	None	-2	27	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
		CHEMBL1256645	209533	19	None	-2	27	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
		CHEMBL1814790	209533	19	None	-2	27	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
		CHEMBL62	209533	19	None	-2	27	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2013.03.016
		3036864	209533	19	None	-2	27	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL1256645	209533	19	None	-2	27	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL1814790	209533	19	None	-2	27	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL62	209533	19	None	-2	27	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		5281878	8441	35	None	-11	16	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		5281881	8441	35	None	-11	16	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		948	8441	35	None	-11	16	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		968	8441	35	None	-11	16	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		CHEMBL42055	8441	35	None	-11	16	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		CHEMBL54661	8441	35	None	-11	16	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		DB00875	8441	35	None	-11	16	Rat	9.5	pIC50	=	9.5	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2003.08.063
		5018	10322	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
		943	10322	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
		946	10322	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
		CHEMBL13668	10322	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [3H]SCH 23390 from human recombinant dopamine D1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.11.014
		5018	10322	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
		943	10322	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
		946	10322	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
		CHEMBL13668	10322	13	None	2	10	Human	9.5	pIC50	=	9.5	Binding	Displacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant Dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2016.03.006
		44358126	33452	0	None	-	0	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	315	1	1	2	4.2	C[C@H]1N(C)CCc2cc(Cl)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm00022a004
		CHEMBL136190	33452	0	None	-	0	Rat	9.4	pIC50	=	9.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	315	1	1	2	4.2	C[C@H]1N(C)CCc2cc(Cl)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
		CHEMBL62	209533	19	None	-2	27	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00002a013
		11795296	33540	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136260	33540	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
		CHEMBL1256645	209533	19	None	-2	27	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
		CHEMBL1814790	209533	19	None	-2	27	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
		CHEMBL62	209533	19	None	-2	27	Human	9.2	pIC50	=	9.2	Binding	Percent inhibition against Dopamine receptor D1 at 1 uMPercent inhibition against Dopamine receptor D1 at 1 uM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm058018d
		10809333	33964	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136630	33964	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		10522247	33504	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136235	33504	0	None	-	0	Rat	9.2	pIC50	=	9.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
		CHEMBL1256645	209533	19	None	-2	27	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
		CHEMBL1814790	209533	19	None	-2	27	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
		CHEMBL62	209533	19	None	-2	27	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm701575k
		10784787	33494	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	360	2	0	3	5.0	CN1CCN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136226	33494	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	360	2	0	3	5.0	CN1CCN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		11795296	33540	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136260	33540	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
		CHEMBL1256645	209533	19	None	-2	27	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
		CHEMBL1814790	209533	19	None	-2	27	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
		CHEMBL62	209533	19	None	-2	27	Human	9.1	pIC50	=	9.1	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2010.07.034
		10712649	125985	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL343282	125985	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		10810927	126074	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL343922	126074	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		10522247	33504	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136235	33504	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		11794473	126108	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCC2	10.1021/jm00022a004
		CHEMBL344206	126108	0	None	-	0	Rat	9.1	pIC50	=	9.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCC2	10.1021/jm00022a004
		10810927	126074	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL343922	126074	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL1256645	209533	19	None	-2	27	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL1814790	209533	19	None	-2	27	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL62	209533	19	None	-2	27	Human	9.0	pIC50	=	9.0	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		10787324	33629	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	402	4	1	3	4.4	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCO	10.1021/jm00022a004
		CHEMBL136340	33629	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	402	4	1	3	4.4	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCO	10.1021/jm00022a004
		10574585	34198	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL136822	34198	0	None	-	0	Rat	9.0	pIC50	=	9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
		CHEMBL62	209533	19	None	-2	27	Rat	9.0	pIC50	=	9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00168a034
		3036864	209533	19	None	-2	27	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
		CHEMBL62	209533	19	None	-2	27	Rat	9.0	pIC50	=	9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00041a025
		10043978	34021	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL136683	34021	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		10525990	34345	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	5	1	3	4.8	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCCO	10.1021/jm00022a004
		CHEMBL136932	34345	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	5	1	3	4.8	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1CCCO	10.1021/jm00022a004
		10247592	35677	1	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL137960	35677	1	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		6603950	210103	9	None	-6	8	Rat	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
		CHEMBL64875	210103	9	None	-6	8	Rat	8.9	pIC50	=	8.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
		6603950	210103	9	None	-6	8	Rat	8.9	pIC50	=	8.9	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		CHEMBL64875	210103	9	None	-6	8	Rat	8.9	pIC50	=	8.9	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		107995	103901	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
		29982233	103901	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
		CHEMBL267723	103901	20	None	-	5	Rat	8.9	pIC50	=	8.9	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmcl.2003.08.063
		10809333	33964	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136630	33964	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
		CHEMBL1256645	209533	19	None	-2	27	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
		CHEMBL1814790	209533	19	None	-2	27	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
		CHEMBL62	209533	19	None	-2	27	Rat	8.9	pIC50	=	8.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a022
		10712649	125985	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL343282	125985	0	None	-	0	Rat	8.9	pIC50	=	8.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL1256645	209533	19	None	-2	27	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL1814790	209533	19	None	-2	27	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL62	209533	19	None	-2	27	Human	8.9	pIC50	=	8.9	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		10835172	125957	0	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	406	2	0	2	5.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL343078	125957	0	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	406	2	0	2	5.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1(C)C	10.1021/jm00022a004
		10247592	35677	1	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL137960	35677	1	None	-	0	Rat	8.8	pIC50	=	8.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		10525999	34136	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Br)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136776	34136	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	416	2	0	2	5.2	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Br)cc32)CC1(C)C	10.1021/jm00022a004
		10574585	34198	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL136822	34198	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		5016	115946	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL32145	115946	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL544114	115946	8	None	-	2	Rat	8.0	pIC50	=	8	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00086a016
		146025812	181670	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4564103	181670	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		10049758	211424	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	457	2	0	7	3.7	CN1CCN(C2=Nc3ccccc3Sc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL73589	211424	0	None	-	0	Rat	7.0	pIC50	=	7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	457	2	0	7	3.7	CN1CCN(C2=Nc3ccccc3Sc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		177725	180045	2	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)C[C@H]1c3c(ccc(O)c3O2)CCN1C	10.1021/jm060959i
		CHEMBL452510	180045	2	None	-	0	Rat	7.0	pIC50	=	7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)C[C@H]1c3c(ccc(O)c3O2)CCN1C	10.1021/jm060959i
		159034	180046	3	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1ccc2c(c1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL452512	180046	3	None	-	0	Rat	6.0	pIC50	=	6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1ccc2c(c1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		15657216	19769	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL1189682	19769	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL539274	19769	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	303	6	0	1	4.8	C=CCN(CC=C)C1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		15657214	20010	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL1191339	20010	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL542419	20010	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	263	4	1	1	3.9	C=CCNC1Cc2ccccc2C(c2ccccc2)C1	10.1021/jm00069a013
		10252000	105323	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL27650	105323	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50188	105323	0	None	-	1	Bovine	5.0	pIC50	=	5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	0	5	3.8	CCCN(CCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		15065270	119133	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	249	2	1	4	2.5	CCCN1CCC2=C(CCc3sc(N)nc32)C1	10.1021/jm00113a010
		CHEMBL329444	119133	0	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	249	2	1	4	2.5	CCCN1CCC2=C(CCc3sc(N)nc32)C1	10.1021/jm00113a010
		194775	214098	27	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	223	3	1	4	2.2	CCCN1CCC=C(c2csc(N)n2)C1	10.1021/jm00113a010
		CHEMBL93428	214098	27	None	-	0	Rat	5.0	pIC50	=	5	Binding	In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390In vitro binding affinity towards dopamine receptor D1 in rat striatal membrane using [3H]-SCH- 23390	ChEMBL	223	3	1	4	2.2	CCCN1CCC=C(c2csc(N)n2)C1	10.1021/jm00113a010
		10008463	18021	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178971	18021	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51985	18021	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	457	9	0	4	4.3	CCC[N+](C)(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		11743327	105478	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		CHEMBL27763	105478	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	428	8	1	5	3.9	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		131001	105769	7	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		CHEMBL27995	105769	7	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	249	5	1	3	2.8	CCCN(CCC)C1COc2cccc(O)c2C1	10.1021/jm00038a007
		10364722	105861	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	105861	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	105861	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		3082597	106335	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283606	106335	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9975915	106512	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL284912	106512	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	362	9	0	5	2.8	CCCN(CCCCN1CCOCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10338595	169278	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL416747	169278	0	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	360	9	0	4	4.0	CCCN(CCCCN1CCCCC1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10707563	35128	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	275	3	0	3	3.3	CCCN1CCCCC12COc1cccc(OC)c1C2	10.1021/jm950861w
		CHEMBL137478	35128	0	None	-	0	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	275	3	0	3	3.3	CCCN1CCCCC12COc1cccc(OC)c1C2	10.1021/jm950861w
		3082597	106335	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL283606	106335	8	None	-	1	Bovine	4.0	pIC50	=	4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	263	6	0	3	3.1	CCCN(CCC)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		14138285	151933	6	None	-	1	Human	6.0	pIC50	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
		CHEMBL3912178	151933	6	None	-	1	Human	6.0	pIC50	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
		71109989	160554	0	None	6	2	Human	7.0	pIC50	=	7.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3982119	160554	0	None	6	2	Human	7.0	pIC50	=	7.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		9992356	16528	1	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		CHEMBL113477	16528	1	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		440585	19463	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
		CHEMBL1187468	19463	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
		CHEMBL503882	19463	15	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	596	8	3	8	6.2	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3O)cc1)N(C)CC2	10.1021/np50087a016
		135221	151997	5	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		CHEMBL3912606	151997	5	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		135398737	7745	93	None	-44	90	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	7745	93	None	-44	90	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	7745	93	None	-44	90	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	7745	93	None	-44	90	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	7745	93	None	-44	90	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		10015045	20424	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
		CHEMBL119455	20424	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
		6603799	106490	17	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		CHEMBL284746	106490	17	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		150	9287	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	9287	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	9287	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	9287	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	9287	21	None	-43	16	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		14901831	20156	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1192581	20156	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL543838	20156	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		3168	16034	92	None	-89	22	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	16034	92	None	-89	22	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		16104	168696	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm991005d
		CHEMBL415300	168696	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm991005d
		16104	168696	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm9704457
		CHEMBL415300	168696	19	None	-1	5	Rat	8.0	pIC50	=	8.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm9704457
		6603820	102549	19	None	1	12	Rat	7.9	pIC50	=	7.9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		CHEMBL25856	102549	19	None	1	12	Rat	7.9	pIC50	=	7.9	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		1353	8692	93	None	-38	85	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	8692	93	None	-38	85	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	8692	93	None	-38	85	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	8692	93	None	-38	85	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	8692	93	None	-38	85	Human	7.0	pIC50	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		10015045	20424	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		CHEMBL119455	20424	1	None	-2	6	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		146025812	181670	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4564103	181670	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		10043978	34021	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL136683	34021	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		14901827	19825	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1190039	19825	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL540036	19825	1	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	225	6	1	2	2.8	CCCN(CC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		44584684	19214	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		CHEMBL1186001	19214	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		CHEMBL445011	19214	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@H](Cc1ccc(OC)c(c1)-c1cc(ccc1O)C(=O)[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		2398	7741	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	7741	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	7741	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	7741	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	7741	62	None	-11	29	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		44317479	212524	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.	ChEMBL	243	4	3	3	2.4	NCC(Cc1ccccc1)c1ccc(O)c(O)c1	10.1021/jm00013a015
		CHEMBL82706	212524	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.Binding affinity to the dopamine receptor D1 by displacing [3H]-SCH- 23390 radio-ligand in rat striatal membranes by using radioligand competition assay.	ChEMBL	243	4	3	3	2.4	NCC(Cc1ccccc1)c1ccc(O)c(O)c1	10.1021/jm00013a015
		10885636	117793	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL326263	117793	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	503	9	0	4	5.7	N#Cc1ccc(CCOC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		10024827	19909	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1190552	19909	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL541096	19909	2	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1cccc(O)c1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		70684206	82840	0	None	11	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057442	82840	0	None	11	2	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70692652	82839	0	None	8	2	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
		CHEMBL2057441	82839	0	None	8	2	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
		10547041	30586	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.8	Oc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
		CHEMBL133615	30586	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.8	Oc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
		14901829	19915	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1190633	19915	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL541304	19915	0	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	239	7	1	2	3.2	CCCN(CCC)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		10264849	16139	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	265	0	1	2	3.3	CN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
		CHEMBL111348	16139	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	265	0	1	2	3.3	CN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
		107715	207724	22	None	-144	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	207724	22	None	-144	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	207724	22	None	-144	20	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		8447	195728	84	None	-8	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		CHEMBL508112	195728	84	None	-8	13	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		3191	109635	97	None	-12	25	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	109635	97	None	-12	25	Human	5.9	pIC50	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		13154762	109887	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		CHEMBL307717	109887	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		15648961	114178	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	341	2	0	1	5.4	CN1CCC(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		CHEMBL317982	114178	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	341	2	0	1	5.4	CN1CCC(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		6603820	102549	19	None	1	12	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00168a034
		CHEMBL25856	102549	19	None	1	12	Rat	7.9	pIC50	=	7.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00168a034
		6917970	10463	61	None	-1	33	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		8370	10463	61	None	-1	33	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		CHEMBL487387	10463	61	None	-1	33	Human	7.9	pIC50	=	7.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		6604005	163896	2	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm00168a034
		CHEMBL407489	163896	2	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	247	1	3	4	2.4	Oc1ccc([C@@H]2CNCc3sccc32)cc1O	10.1021/jm00168a034
		10361722	28992	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.5	Oc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
		CHEMBL132304	28992	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	369	2	1	2	3.5	Oc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
		10333742	66174	1	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	277	2	0	1	4.1	c1ccc(CN2CCCC3Cc4ccccc4CC32)cc1	10.1016/s0960-894x(01)00076-2
		CHEMBL170974	66174	1	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	277	2	0	1	4.1	c1ccc(CN2CCCC3Cc4ccccc4CC32)cc1	10.1016/s0960-894x(01)00076-2
		42	8844	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		56971	8844	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL8412	8844	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		42	8844	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
		56971	8844	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
		CHEMBL8412	8844	57	None	-	18	Bovine	4.9	pIC50	=	4.9	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	401	6	0	7	1.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950861w
		44370646	54989	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@H](C2)N(C)CC3	10.1021/jm00164a022
		CHEMBL155246	54989	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@H](C2)N(C)CC3	10.1021/jm00164a022
		44269133	40709	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	356	2	3	3	2.1	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL14239	40709	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	356	2	3	3	2.1	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		72329	102423	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	337	2	2	5	4.0	COc1c(O)c2c3c(nccc3c1OC)C(C)(C)c1cc(O)ccc1-2	10.1021/jm060959i
		CHEMBL257958	102423	1	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	337	2	2	5	4.0	COc1c(O)c2c3c(nccc3c1OC)C(C)(C)c1cc(O)ccc1-2	10.1021/jm060959i
		64143	205643	62	None	-1	8	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		CHEMBL584	205643	62	None	-1	8	Human	4.9	pIC50	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		10523361	36598	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC(C)N1C	10.1021/jm00022a004
		CHEMBL138745	36598	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC(C)N1C	10.1021/jm00022a004
		10567738	126184	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	320	2	0	2	4.3	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL344680	126184	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	320	2	0	2	4.3	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		71109797	152674	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		CHEMBL3917753	152674	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		135398737	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		38	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		722	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		CHEMBL42	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		DB00363	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00022a004
		15653096	214669	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
		CHEMBL1788129	214669	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
		CHEMBL96618	214669	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1	10.1021/jm00022a004
		135398737	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		38	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		722	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		CHEMBL42	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		DB00363	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm991005d
		135398737	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		38	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		722	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		CHEMBL42	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		DB00363	7745	93	None	-83	90	Rat	6.9	pIC50	=	6.9	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9704457
		100	10577	58	None	-16	54	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		2637	10577	58	None	-16	54	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		5452	10577	58	None	-16	54	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		CHEMBL479	10577	58	None	-16	54	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		DB00679	10577	58	None	-16	54	Rat	5.9	pIC50	=	5.9	Binding	Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1Affinity for displacement of [3H]clonidine labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		131213	12074	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL106622	12074	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		131213	12074	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL106622	12074	1	None	-	2	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	2	3	3.8	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		44312870	211356	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
		CHEMBL73082	211356	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
		44285576	149029	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C/c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
		CHEMBL38848	149029	0	None	-	0	Rat	5.9	pIC50	=	5.9	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C/c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
		12545	54433	12	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	281	1	1	3	3.2	COc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
		CHEMBL154709	54433	12	None	-	0	Rat	4.9	pIC50	=	4.9	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	281	1	1	3	3.2	COc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
		195158	49925	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
		CHEMBL150550	49925	1	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
		44267161	169821	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	456	10	0	5	4.4	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		CHEMBL417608	169821	0	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	456	10	0	5	4.4	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		70690498	82842	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057445	82842	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		71109805	94280	0	None	27	3	Human	7.8	pIC50	=	7.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
		CHEMBL2334881	94280	0	None	27	3	Human	7.8	pIC50	=	7.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
		70690500	82848	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		CHEMBL2057455	82848	0	None	-	1	Human	5.9	pIC50	=	5.9	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		70692653	82841	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
		CHEMBL2057443	82841	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
		70692653	82841	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL2057443	82841	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		146025817	182796	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4589737	182796	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		22857296	35923	0	None	-	4	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13816	35923	0	None	-	4	Rat	5.9	pIC50	=	5.9	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	389	4	2	3	4.1	CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		146025817	182796	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4589737	182796	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	309	2	0	3	3.8	COc1ccc2c(c1OC)-c1ccc(C)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		15720219	75440	1	None	-	1	Rat	4.8	pIC50	=	4.8	Binding	Compound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranesCompound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranes	ChEMBL	220	5	0	2	2.9	CCCN(CCC)[C@H]1CCn2cccc2C1	10.1016/S0960-894X(00)80003-7
		CHEMBL192037	75440	1	None	-	1	Rat	4.8	pIC50	=	4.8	Binding	Compound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranesCompound was evaluated for binding affinity to Dopamine receptor D1 labeled with [3H]-SCH- 23390 (0.3 nM) in rat striatal membranes	ChEMBL	220	5	0	2	2.9	CCCN(CCC)[C@H]1CCn2cccc2C1	10.1016/S0960-894X(00)80003-7
		146025813	182366	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4579687	182366	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		6603820	102549	19	None	1	12	Rat	6.8	pIC50	=	6.8	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		CHEMBL25856	102549	19	None	1	12	Rat	6.8	pIC50	=	6.8	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		2585	7590	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	7590	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	7590	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	7590	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	7590	103	None	-112	22	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		71474024	151246	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		CHEMBL3906676	151246	0	None	-	1	Human	5.8	pIC50	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		10247592	35677	1	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL137960	35677	1	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	2	0	2	4.9	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		146025816	176757	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4442011	176757	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		146025816	176757	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4442011	176757	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		44190762	183659	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from dopamine D1 receptorDisplacement of radioligand from dopamine D1 receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		CHEMBL461571	183659	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of radioligand from dopamine D1 receptorDisplacement of radioligand from dopamine D1 receptor	ChEMBL	531	8	1	5	6.6	Cc1c(C(=O)c2ccc(Cl)cc2)c2ccc(OC(F)(F)F)cc2n1Cc1cccc(O[C@H](C)C(=O)O)c1	10.1016/j.bmcl.2008.07.103
		26987	7736	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	7736	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	7736	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	7736	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	7736	33	None	-245	21	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		9851833	19212	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
		CHEMBL1185978	19212	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
		CHEMBL443953	19212	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	608	3	1	8	6.9	COc1ccc2cc1Oc1ccc(cc1)C[C@@H]1c3c(cc(OC)c(O)c3Oc3cc4c(cc3OC)CCN(C)[C@H]4C2)CCN1C	10.1021/np50087a016
		2274	9947	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	9947	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	9947	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	9947	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	9947	58	None	-16	31	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		44284723	144899	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C/C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		CHEMBL37661	144899	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C/C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		277	8083	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	8083	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	8083	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	8083	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	8083	62	None	-33	50	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		146025815	176558	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4439029	176558	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		15115476	33879	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	2	0	2	4.2	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
		CHEMBL136553	33879	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	326	2	0	2	4.2	CN1CCN(C2CC(c3ccccc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
		10320519	33888	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	4	1	3	3.2	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		CHEMBL136562	33888	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	4	1	3	3.2	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		146025815	176558	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		CHEMBL4439029	176558	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	323	3	0	3	4.0	CCc1ccc2c3c1CCN(C)[C@@H]3Cc1ccc(OC)c(OC)c1-2	10.1021/acsmedchemlett.9b00575
		10732779	195050	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	297	4	2	3	3.7	CCCN1CCc2cc(O)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm001128u
		CHEMBL49995	195050	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	297	4	2	3	3.7	CCCN1CCc2cc(O)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm001128u
		10264176	118103	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		CHEMBL326781	118103	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1ccc2c(c1)[C@@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		10048240	20166	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1192639	20166	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL543914	20166	1	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	347	9	2	3	4.6	CCCN(CCCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		44358170	35060	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	378	2	0	2	4.7	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
		CHEMBL137430	35060	0	None	-	0	Rat	7.8	pIC50	=	7.8	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	378	2	0	2	4.7	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
		100	10577	58	None	-16	54	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		2637	10577	58	None	-16	54	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		5452	10577	58	None	-16	54	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		CHEMBL479	10577	58	None	-16	54	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		DB00679	10577	58	None	-16	54	Rat	7.8	pIC50	=	7.8	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00393a021
		44370644	55575	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm060959i
		CHEMBL155884	55575	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm060959i
		240	7731	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		2769	7731	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		44279790	7731	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		660	7731	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		CHEMBL1729	7731	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		CHEMBL560739	7731	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		DB00604	7731	43	None	-	25	Human	5.8	pIC50	=	5.8	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm0509501
		44370644	55575	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
		CHEMBL155884	55575	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
		6603798	106956	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL1613539	106956	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL288096	106956	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		6603798	106956	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL1613539	106956	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL288096	106956	5	None	-17378	2	Rat	5.8	pIC50	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		14140118	102371	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	1	4	3.2	COc1c(O)c2c3c(c1OC)CCN(C)C3Cc1ccccc1-2	10.1021/jm060959i
		CHEMBL257747	102371	0	None	-	0	Rat	4.8	pIC50	=	4.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	1	4	3.2	COc1c(O)c2c3c(c1OC)CCN(C)C3Cc1ccccc1-2	10.1021/jm060959i
		1043	8363	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	8363	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	8363	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	8363	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	8363	14	None	-9549	29	Human	5.8	pIC50	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		1588	9105	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	9105	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	9105	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	9105	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	9105	27	None	-131	44	Human	6.8	pIC50	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		15653097	213971	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		CHEMBL2111567	213971	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		CHEMBL92560	213971	0	None	-	0	Rat	5.8	pIC50	=	5.8	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		9979207	20610	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1195842	20610	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL555427	20610	2	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	333	8	2	3	4.2	CCCN(CCc1ccc(O)cc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		44370749	55513	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
		CHEMBL155833	55513	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
		70692652	82839	0	None	8	2	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057441	82839	0	None	8	2	Human	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		6603729	106732	2	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@H](c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL286424	106732	2	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@H](c2ccccc2)C1	10.1021/jm00086a016
		192611	20341	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL1193985	20341	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL545477	20341	7	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	301	2	1	2	4.1	CN(C)[C@H]1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		10595484	125868	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)C(C)CN1C	10.1021/jm00022a004
		CHEMBL342698	125868	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)C(C)CN1C	10.1021/jm00022a004
		71240	214496	14	None	-	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	408	4	1	3	4.0	OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00072a006
		CHEMBL95636	214496	14	None	-	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	408	4	1	3	4.0	OCCN1CCN([C@@H]2C[C@@H](c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00072a006
		1241	106955	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL288090	106955	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL552611	106955	24	None	-1	8	Rat	7.7	pIC50	=	7.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00086a016
		1242	10385	27	None	1	17	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
		935	10385	27	None	1	17	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
		CHEMBL286080	10385	27	None	1	17	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00086a016
		44269117	104088	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	352	2	2	4	3.2	CN1C[C@H](C(=O)Nc2nccs2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL269160	104088	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	352	2	2	4	3.2	CN1C[C@H](C(=O)Nc2nccs2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		10831881	123250	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	4.1	I/C=C/CN1CCC[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm980284m
		CHEMBL336128	123250	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	4.1	I/C=C/CN1CCC[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm980284m
		71474025	152105	0	None	131	2	Human	5.7	pIC50	=	5.7	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3913343	152105	0	None	131	2	Human	5.7	pIC50	=	5.7	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		135398737	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		38	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		722	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		CHEMBL42	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		DB00363	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00130a006
		135398737	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		38	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		722	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		CHEMBL42	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		DB00363	7745	93	None	-83	90	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00164a053
		100	10577	58	None	-47	54	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	10577	58	None	-47	54	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	10577	58	None	-47	54	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	10577	58	None	-47	54	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	10577	58	None	-47	54	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		129503	168447	10	None	-	4	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		CHEMBL413105	168447	10	None	-	4	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)C1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		2750	210840	76	None	-5	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	210840	76	None	-5	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		10043978	34021	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL136683	34021	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	1	2	4.7	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		10641744	38102	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	352	2	0	2	4.7	Cc1ccc2c(c1)C(N1CCN(C)C(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL140189	38102	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	352	2	0	2	4.7	Cc1ccc2c(c1)C(N1CCN(C)C(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		10810109	122273	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	Fc1ccc(C2CC(N3CCN4CCCCC4C3)c3cc(Cl)ccc32)cc1	10.1021/jm00022a004
		CHEMBL335155	122273	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	384	2	0	2	5.2	Fc1ccc(C2CC(N3CCN4CCCCC4C3)c3cc(Cl)ccc32)cc1	10.1021/jm00022a004
		9819535	105723	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.	ChEMBL	344	2	1	4	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(N=C=S)c2)C1	10.1016/0960-894X(96)00186-2
		CHEMBL279634	105723	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.Compound was tested for binding affinity against Dopamine receptor D1 using 1 nM [3H]SCH-23390 as the radioligand.	ChEMBL	344	2	1	4	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(N=C=S)c2)C1	10.1016/0960-894X(96)00186-2
		2726	7706	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		621	7706	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		83	7706	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		CHEMBL71	7706	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		DB00477	7706	68	None	-18	72	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00002a013
		12765746	109057	4	None	-18	9	Rat	8.7	pIC50	=	8.7	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
		CHEMBL303313	109057	4	None	-18	9	Rat	8.7	pIC50	=	8.7	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm020938y
		12765746	109057	4	None	-18	9	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		CHEMBL303313	109057	4	None	-18	9	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		1238	209953	24	None	-5	16	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		CHEMBL64249	209953	24	None	-5	16	Rat	8.7	pIC50	=	8.7	Binding	Ability to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranesAbility to inhibit binding of [3H]-SCH- 23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00111a015
		12765746	109057	4	None	-18	9	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		CHEMBL303313	109057	4	None	-18	9	Rat	8.7	pIC50	=	8.7	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		10666149	126110	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	0	2	4.7	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
		CHEMBL344216	126110	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	358	2	0	2	4.7	CC1CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
		10246528	34065	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136722	34065	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		3036864	209533	19	None	-2	27	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL1256645	209533	19	None	-2	27	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL1814790	209533	19	None	-2	27	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL62	209533	19	None	-2	27	Human	8.6	pIC50	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		5018	10322	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		943	10322	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		946	10322	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		CHEMBL13668	10322	13	None	2	10	Human	8.6	pIC50	=	8.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		10810514	33989	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	392	2	1	2	5.1	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CCN1	10.1021/jm00022a004
		CHEMBL136648	33989	0	None	-	0	Rat	8.6	pIC50	=	8.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	392	2	1	2	5.1	CC1(C)CN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CCN1	10.1021/jm00022a004
		135514603	210893	14	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	474	2	1	7	4.0	CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL70319	210893	14	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	474	2	1	7	4.0	CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		681	8247	72	None	-23	38	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		940	8247	72	None	-23	38	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		947	8247	72	None	-23	38	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		CHEMBL59	8247	72	None	-23	38	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		DB00988	8247	72	None	-23	38	Bovine	6.7	pIC50	=	6.7	Binding	In vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine D1 receptor using [3H]-SCH- 23390 as radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(00)80265-6
		15653098	214027	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1	10.1021/jm00022a004
		CHEMBL92896	214027	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1	10.1021/jm00022a004
		121852	16938	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL11592	16938	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL301060	16938	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9978353	18025	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		CHEMBL1178987	18025	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		CHEMBL52785	18025	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	7	1	5	3.1	COc1cccc2c1CC(NCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm00038a007
		9981024	102872	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26018	102872	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL300735	102872	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10319624	105763	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL27991	105763	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL298534	105763	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	10	1	4	4.1	CCCN(CCCCNC(=O)c1ccc(F)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9980269	105859	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280586	105859	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL54266	105859	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	432	10	1	5	3.4	CCCN(CCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10321248	106202	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL28287	106202	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50722	106202	0	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	444	9	0	6	3.7	CCCN(CCCON1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		121852	16938	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL11592	16938	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL301060	16938	7	None	-	1	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		10333685	95319	3	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	276	1	1	1	3.8	CN1CCc2c([nH]c3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
		CHEMBL23529	95319	3	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	276	1	1	1	3.8	CN1CCc2c([nH]c3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
		14233815	213785	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CCC21	10.1021/jm00113a010
		CHEMBL91453	213785	1	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CCC21	10.1021/jm00113a010
		71109993	150025	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
		CHEMBL3896617	150025	0	None	-	1	Human	5.7	pIC50	=	5.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
		14547414	109061	1	None	-	4	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		CHEMBL303339	109061	1	None	-	4	Rat	4.7	pIC50	=	4.7	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		28417	46813	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	46813	49	None	-1	12	Human	4.7	pIC50	=	4.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		10480509	149109	0	None	-	2	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	483	2	2	5	4.4	COc1cc2c(c(Br)c1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL388564	149109	0	None	-	2	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	483	2	2	5	4.4	COc1cc2c(c(Br)c1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		44312605	211214	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		CHEMBL72162	211214	0	None	-	0	Rat	7.7	pIC50	=	7.7	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		44323851	213753	0	None	3	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		CHEMBL91310	213753	0	None	3	4	Rat	7.7	pIC50	=	7.7	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		13154801	34224	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	370	5	1	4	3.0	COc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL136841	34224	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	370	5	1	4	3.0	COc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		24121307	109820	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(C)(=O)=O)cc32)CC1	10.1021/jm991005d
		CHEMBL307163	109820	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(C)(=O)=O)cc32)CC1	10.1021/jm991005d
		3117	214620	103	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	214620	103	None	-2	16	Human	5.7	pIC50	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		147080	212755	5	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.	ChEMBL	365	6	0	6	2.8	O=c1ccoc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc12	10.1021/jm00105a039
		CHEMBL84639	212755	5	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.Compound was tested for its inhibitory effect on the binding profile in Dopamine receptor D1 using [3H]flupenthixol in rat brain.	ChEMBL	365	6	0	6	2.8	O=c1ccoc2cc(OCCCN3CCN(c4ccccn4)CC3)ccc12	10.1021/jm00105a039
		44354812	31901	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	3.8	I/C=C/CN1CCCC2Cc3ccccc3CC21	10.1021/jm980284m
		CHEMBL134746	31901	0	None	-	0	Rat	6.7	pIC50	=	6.7	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	353	2	0	1	3.8	I/C=C/CN1CCCC2Cc3ccccc3CC21	10.1021/jm980284m
		44285034	156546	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C\C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		CHEMBL39483	156546	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	305	6	0	1	5.0	C(=C\C1CCCN(CCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		135493554	210939	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3cc(OS(C)(=O)=O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		CHEMBL70609	210939	0	None	-	0	Rat	4.7	pIC50	=	4.7	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	386	2	1	7	2.4	CN1CCN(C2=Nc3cc(OS(C)(=O)=O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		125720	33087	5	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	338	2	2	3	1.7	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13588	33087	5	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	338	2	2	3	1.7	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		9911120	16395	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		CHEMBL11265	16395	0	None	-	0	Bovine	4.7	pIC50	=	4.7	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		2726	7706	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	7706	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	7706	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	7706	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	7706	68	None	-36	72	Human	6.7	pIC50	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		4913274	24772	2	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	408	4	1	3	4.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
		CHEMBL12628	24772	2	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	408	4	1	3	4.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(C(F)(F)F)cc32)CC1	10.1021/jm00022a004
		15648962	115129	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	339	2	0	1	5.3	CN1CC=C(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		CHEMBL319810	115129	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	339	2	0	1	5.3	CN1CC=C(C2=CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		1212	8443	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	8443	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	8443	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	8443	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	8443	50	None	-51	65	Human	7.6	pIC50	=	7.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		146025814	179558	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4513262	179558	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		9911120	16395	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		CHEMBL11265	16395	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	440	6	0	5	4.0	COc1cccc2c1CC1(CCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		11744707	171688	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	454	6	0	5	4.3	COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		CHEMBL422283	171688	0	None	-	0	Bovine	4.6	pIC50	=	4.6	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	454	6	0	5	4.3	COc1cccc2c1CC1(CCCCN1CCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1021/jm950861w
		228	7233	28	None	-30	23	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		33	7233	28	None	-30	23	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		6005	7233	28	None	-30	23	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		CHEMBL53	7233	28	None	-30	23	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		DB00714	7233	28	None	-30	23	Rat	6.6	pIC50	=	6.6	Binding	In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1In vitro antagonist binding affinity was determined by displacing the [3H]-SCH- in rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)81245-2
		10400783	201664	0	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	267	2	1	3	2.8	c1ccc(C[C@@H]2NCCc3cc4c(cc32)OCO4)cc1	10.1021/jm001128u
		CHEMBL54051	201664	0	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	267	2	1	3	2.8	c1ccc(C[C@@H]2NCCc3cc4c(cc32)OCO4)cc1	10.1021/jm001128u
		10531	8202	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	8202	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	8202	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	8202	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	8202	21	None	-218	24	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		440989	102075	27	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	285	3	3	4	2.5	COc1cc2c(cc1O)[C@@H](Cc1ccc(O)cc1)NCC2	10.1021/np980008a
		CHEMBL256448	102075	27	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	285	3	3	4	2.5	COc1cc2c(cc1O)[C@@H](Cc1ccc(O)cc1)NCC2	10.1021/np980008a
		10408602	20468	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1194852	20468	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL553399	20468	2	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	317	8	1	2	4.5	CCCN(CCc1ccccc1)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		2284	9956	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	9956	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	9956	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	9956	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	9956	33	None	-36	29	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		10246528	34065	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136722	34065	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		22179	193044	42	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	3	5	2.5	COc1cc2c(cc1O)C[C@@H]1NCCc3cc(O)c(OC)c-2c31	10.1021/jm060959i
		CHEMBL487388	193044	42	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	2	3	5	2.5	COc1cc2c(cc1O)C[C@@H]1NCCc3cc(O)c(OC)c-2c31	10.1021/jm060959i
		11035765	16660	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	359	6	2	6	3.3	Oc1nc2ccccc2n1CCCNCc1cc2c(cc1Cl)OCO2	10.1021/jm010878g
		CHEMBL114280	16660	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	359	6	2	6	3.3	Oc1nc2ccccc2n1CCCNCc1cc2c(cc1Cl)OCO2	10.1021/jm010878g
		49836496	25327	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	246	2	1	1	3.5	CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1	10.1021/jm100515z
		CHEMBL1275791	25327	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	246	2	1	1	3.5	CN(C)[C@H]1CC[C@@H](c2c[nH]c3ccc(F)cc23)C1	10.1021/jm100515z
		146025814	179558	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4513262	179558	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		197505	20463	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1194829	20463	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL553361	20463	16	None	-	0	Rat	4.6	pIC50	=	4.6	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	171	2	2	2	1.5	NCCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		441383	27105	57	None	-12	17	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	27105	57	None	-12	17	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		2600	10551	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	10551	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	10551	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	10551	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	10551	74	None	-7	13	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		10762505	171636	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	4.1	COc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
		CHEMBL421914	171636	0	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	4.1	COc1cccc2c1CC[C@@H]1[C@@H]2CCCN1C/C=C/I	10.1021/jm980284m
		2477	7532	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		36	7532	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		437	7532	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		CHEMBL49	7532	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		DB00490	7532	59	None	-28	29	Bovine	4.6	pIC50	=	4.6	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm00038a007
		44342270	16702	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		CHEMBL114484	16702	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	355	3	1	4	4.5	Cc1ccc(CN2CCC(n3c(O)nc4ccccc43)CC2)c(Cl)c1	10.1021/jm010878g
		2286	9957	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	9957	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	9957	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	9957	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	9957	51	None	-30	30	Human	5.6	pIC50	=	5.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		11730467	17800	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		CHEMBL117537	17800	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	476	10	0	2	6.0	O=C(CCCc1ccccc1)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1021/jm010878g
		11080	35858	79	None	-5	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	35858	79	None	-5	6	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		5352624	74013	44	None	-3	5	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
		CHEMBL18797	74013	44	None	-3	5	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
		2662	18156	131	None	-3	30	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
		CHEMBL118	18156	131	None	-3	30	Human	4.6	pIC50	=	4.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
		13154762	109887	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		CHEMBL307717	109887	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		6603997	106686	12	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL286120	106686	12	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00086a016
		15723883	212898	1	None	-	1	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	294	6	0	2	3.8	c1ccc(CCCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm00116a003
		CHEMBL85879	212898	1	None	-	1	Rat	5.6	pIC50	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	294	6	0	2	3.8	c1ccc(CCCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm00116a003
		31101	7516	40	None	-436	35	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	7516	40	None	-436	35	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	7516	40	None	-436	35	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	7516	40	None	-436	35	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	7516	40	None	-436	35	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		10264175	115378	1	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@@H]21	10.1021/jm00002a013
		CHEMBL320481	115378	1	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@@H]21	10.1021/jm00002a013
		196129	74573	17	None	-1819	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	74573	17	None	-1819	15	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		70684207	82845	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057452	82845	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70684207	82845	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057452	82845	0	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
		14547415	107447	1	None	-	4	Rat	4.5	pIC50	=	4.5	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		CHEMBL292274	107447	1	None	-	4	Rat	4.5	pIC50	=	4.5	Binding	In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.In vitro binding activity against dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand.	ChEMBL	214	1	1	1	2.6	CN(C)[C@H]1CCc2ccc3[nH]ccc3c2C1	10.1021/jm00130a008
		73453	36389	24	None	-208	17	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	36389	24	None	-208	17	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		195158	49925	1	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
		CHEMBL150550	49925	1	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Compound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPACompound was tested in vitro for binding affinity against dopamine receptor D1 in rat striatal membrane by using DA antagonist [3H]NPA	ChEMBL	249	2	1	4	2.5	CCCN1CCC=C2c3nc(N)sc3CC[C@@H]21	10.1021/jm00113a010
		21589014	150850	0	None	1	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL3903297	150850	0	None	1	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		10246528	34065	0	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136722	34065	0	None	-	0	Rat	8.5	pIC50	=	8.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	0	2	4.4	CN1CCN(C2CC(c3ccc(F)cc3)c3ccccc32)CC1(C)C	10.1021/jm00022a004
		10004036	102004	0	None	33	2	Rat	8.5	pIC50	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL256075	102004	0	None	33	2	Rat	8.5	pIC50	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		10570260	35214	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(F)c32)CC1(C)C	10.1021/jm00022a004
		CHEMBL137536	35214	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(F)c32)CC1(C)C	10.1021/jm00022a004
		70692655	82849	0	None	8	2	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057456	82849	0	None	8	2	Human	7.5	pIC50	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		15723897	16266	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	330	5	0	2	4.6	c1ccc(N2CCN(CCCc3ccc4ccccc4c3)CC2)cc1	10.1021/jm00116a003
		CHEMBL112037	16266	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	330	5	0	2	4.6	c1ccc(N2CCN(CCCc3ccc4ccccc4c3)CC2)cc1	10.1021/jm00116a003
		228	7233	28	None	-30	23	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		33	7233	28	None	-30	23	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		6005	7233	28	None	-30	23	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		CHEMBL53	7233	28	None	-30	23	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		DB00714	7233	28	None	-30	23	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00171a014
		681	8247	72	None	-97	38	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		940	8247	72	None	-97	38	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		947	8247	72	None	-97	38	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		CHEMBL59	8247	72	None	-97	38	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		DB00988	8247	72	None	-97	38	Rat	5.5	pIC50	=	5.5	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00171a014
		9861399	40071	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	307	2	0	2	4.9	CCN1CCc2c(sc3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
		CHEMBL141863	40071	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	307	2	0	2	4.9	CCN1CCc2c(sc3ccccc23)C(c2ccccc2)C1	10.1021/jm980156y
		10251234	18017	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178932	18017	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50530	18017	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10429859	18814	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		CHEMBL1183429	18814	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		CHEMBL296395	18814	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	380	7	1	5	2.7	COc1cccc2c1CC(NCCCCN1C(=O)c3ccccc3C1=O)CO2	10.1021/jm00038a007
		10476735	20503	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1195096	20503	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL553833	20503	0	None	-	0	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	411	9	0	7	3.5	CCCN(CCCCn1c(=O)oc2cccnc21)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		9981024	102872	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26018	102872	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL300735	102872	0	None	-	1	Bovine	4.5	pIC50	=	4.5	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	446	11	1	5	3.8	CCCN(CCCCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		44312603	110550	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	350	1	0	2	4.9	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		CHEMBL308843	110550	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	350	1	0	2	4.9	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		14728694	12121	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	2	0	3	4.1	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/jm00174a002
		CHEMBL106886	12121	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	2	0	3	4.1	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1ccc2c(c1-3)OCO2	10.1021/jm00174a002
		44319215	19976	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL1191117	19976	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL542167	19976	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.	ChEMBL	265	2	0	1	4.1	CN(C)[C@@]1(C)Cc2ccccc2[C@H](c2ccccc2)C1	10.1021/jm00069a013
		11057	182928	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	182928	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	182928	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	182928	23	None	-2	20	Human	5.5	pIC50	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		10809334	33620	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136334	33620	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cccc(Cl)c32)CC1(C)C	10.1021/jm00022a004
		6761	74574	19	None	-5	18	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	74574	19	None	-5	18	Human	7.5	pIC50	=	7.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		44285043	161589	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C\c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
		CHEMBL40031	161589	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	255	4	0	1	4.4	CC(C)=CCN1CCCC(/C=C\c2ccccc2)C1	10.1016/S0960-894X(97)00253-9
		10043093	210638	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(Br)cc3CC[C@H]21	10.1021/jm00002a013
		CHEMBL68680	210638	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(Br)cc3CC[C@H]21	10.1021/jm00002a013
		70690497	82838	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
		CHEMBL2057438	82838	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
		70690497	82838	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL2057438	82838	0	None	3	2	Human	6.5	pIC50	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		13994412	17936	1	None	-117	3	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
		CHEMBL117841	17936	1	None	-117	3	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00164a022
		7055406	196122	3	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	299	4	2	4	2.8	COc1ccc(C[C@H]2NCCc3cc(O)c(OC)cc32)cc1	10.1021/np980008a
		CHEMBL512542	196122	3	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat striatal dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat striatal dopamine D1 receptor	ChEMBL	299	4	2	4	2.8	COc1ccc(C[C@H]2NCCc3cc(O)c(OC)cc32)cc1	10.1021/np980008a
		9816455	23563	8	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@H]2CNC3	10.1021/jm0101545
		CHEMBL124561	23563	8	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@H]2CNC3	10.1021/jm0101545
		130907	201462	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL53294	201462	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		10091430	16653	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	384	7	1	4	3.3	O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1	10.1016/0960-894X(96)00174-6
		CHEMBL11425	16653	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	384	7	1	4	3.3	O=C1CC2(CCCC2)CC(=O)N1CCCCNCC1COc2ccccc2C1	10.1016/0960-894X(96)00174-6
		457825	179433	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
		CHEMBL449690	179433	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
		CHEMBL506025	179433	40	None	-	0	Rat	4.5	pIC50	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3cc(c(OC)cc3CCN1C)Oc1c(OC)c(OC)cc3c1[C@@H](C2)N(C)CC3	10.1021/np50087a016
		130907	201462	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL53294	201462	5	None	-3311	4	Rat	5.5	pIC50	=	5.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		44370718	126318	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
		CHEMBL345822	126318	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(Br)c(O)c1-3	10.1021/jm00164a022
		1353	8692	93	None	-74	85	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		3559	8692	93	None	-74	85	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		86	8692	93	None	-74	85	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		CHEMBL54	8692	93	None	-74	85	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		DB00502	8692	93	None	-74	85	Rat	6.5	pIC50	=	6.5	Binding	Binding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligandBinding affinity towards Dopamine receptor D1 in rat membranes using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00116a003
		10548369	37218	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	388	2	0	2	5.6	CN1CCN(C2CC(c3ccc(Cl)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL139258	37218	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	388	2	0	2	5.6	CN1CCN(C2CC(c3ccc(Cl)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		9979258	104892	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	415	3	2	2	4.9	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL273526	104892	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	415	3	2	2	4.9	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		44267181	16383	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.	ChEMBL	277	7	0	3	3.4	CCCN(CCC)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		CHEMBL11262	16383	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.Compound was evaluated for the binding affinity towards Dopamine receptor D1 by displacement of [3H]raclopride.	ChEMBL	277	7	0	3	3.4	CCCN(CCC)CC1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		6852376	98374	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
		CHEMBL1467585	98374	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
		CHEMBL24077	98374	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
		CHEMBL503958	98374	13	None	-4	5	Rat	7.5	pIC50	=	7.5	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00168a034
		44269085	31761	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13464	31761	0	None	-	0	Rat	5.5	pIC50	=	5.5	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		180	7189	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	7189	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	7189	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	7189	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	7189	56	None	-109	40	Human	6.5	pIC50	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		1353	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		3559	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		86	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		CHEMBL54	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		DB00502	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991005d
		1353	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		3559	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		86	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		CHEMBL54	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		DB00502	8692	93	None	-74	85	Rat	7.4	pIC50	=	7.4	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9704457
		164710	102370	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	4	2.5	Oc1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
		CHEMBL257746	102370	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	4	2.5	Oc1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
		736083	168993	17	None	-50	2	Rat	5.4	pIC50	=	5.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00164a022
		CHEMBL416288	168993	17	None	-50	2	Rat	5.4	pIC50	=	5.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00164a022
		10619325	34282	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136891	34282	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1(C)C	10.1021/jm00022a004
		71110290	153938	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3927835	153938	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		681	8247	72	None	-97	38	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		940	8247	72	None	-97	38	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		947	8247	72	None	-97	38	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		CHEMBL59	8247	72	None	-97	38	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		DB00988	8247	72	None	-97	38	Rat	5.4	pIC50	=	5.4	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00101a018
		4011	89183	49	None	-64	24	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	89183	49	None	-64	24	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		11005810	17238	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL116463	17238	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	517	10	1	4	6.2	N#Cc1ccc(CCOC(=O)NC2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		44358128	33786	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	324	2	0	2	4.0	Cc1ccc2c(c1)C(N1CCN(C)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL136480	33786	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	324	2	0	2	4.0	Cc1ccc2c(c1)C(N1CCN(C)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		14901835	19687	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
		CHEMBL1189074	19687	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
		CHEMBL538012	19687	0	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	301	8	1	2	4.0	CCCN(CCc1ccccc1)CCc1ccc(O)c(F)c1	10.1021/jm00171a014
		10527884	35147	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	458	8	1	5	3.9	COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2	10.1021/jm950861w
		CHEMBL137486	35147	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	458	8	1	5	3.9	COc1cccc2c1CC1(CCCCN1CCCCNS(=O)(=O)c1ccc(C)cc1)CO2	10.1021/jm950861w
		44269075	35392	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13770	35392	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		10550367	121985	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	426	7	1	4	4.2	COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2	10.1021/jm950861w
		CHEMBL334498	121985	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	426	7	1	4	4.2	COc1cccc2c1CC1(CCCCN1CCCCNC(=O)c1ccc(F)cc1)CO2	10.1021/jm950861w
		228	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		33	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		6005	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		CHEMBL53	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		DB00714	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Compound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligandCompound was tested in vitro for binding affinity towards Dopamine receptor D1 in rat striatal membrane by using [3H]-SCH- 23390 as radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00113a010
		228	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		33	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		6005	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		CHEMBL53	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		DB00714	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390In vitro binding affinity to Dopamine receptor D1 in rat striatal membranes using D1 antagonist [3H]SCH-23390	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/S0960-894X(01)80462-5
		228	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		33	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		6005	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		CHEMBL53	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		DB00714	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determinedInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 was determined	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a051
		2351	10059	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	10059	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	10059	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	10059	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	10059	64	None	-16	21	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		12488	8438	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	8438	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	8438	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	8438	56	None	-19	23	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		13154803	123527	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	386	5	1	4	3.7	CSc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL337542	123527	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	386	5	1	4	3.7	CSc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		100231	184697	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
		CHEMBL451211	184697	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
		CHEMBL464525	184697	7	None	-	0	Rat	4.4	pIC50	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	4	0	8	7.2	COc1ccc2cc1Oc1ccc(cc1)C[C@H]1c3c(cc(OC)c(OC)c3Oc3cc4c(cc3OC)CCN(C)[C@@H]4C2)CCN1C	10.1021/np50087a016
		191	7191	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	7191	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	7191	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	7191	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	7191	98	None	-26	29	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		121852	16938	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		CHEMBL11592	16938	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		CHEMBL301060	16938	7	None	-	1	Human	4.4	pIC50	=	4.4	Binding	Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.Compound was evaluated for the Dopamine receptor D1 by displacement of [3H]SCH-23390.	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1016/0960-894X(96)00174-6
		10452020	125053	3	None	-	3	Rat	8.4	pIC50	=	8.4	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL34095	125053	3	None	-	3	Rat	8.4	pIC50	=	8.4	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm00086a016
		3036864	209533	19	None	-2	27	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
		CHEMBL1256645	209533	19	None	-2	27	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
		CHEMBL1814790	209533	19	None	-2	27	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
		CHEMBL62	209533	19	None	-2	27	Rat	8.4	pIC50	=	8.4	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm980156y
		3036864	209533	19	None	-2	27	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL1256645	209533	19	None	-2	27	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL1814790	209533	19	None	-2	27	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL62	209533	19	None	-2	27	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		3036864	209533	19	None	-2	27	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL1256645	209533	19	None	-2	27	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL1814790	209533	19	None	-2	27	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		CHEMBL62	209533	19	None	-2	27	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/acsmedchemlett.9b00575
		10809335	33772	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccccc3F)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136468	33772	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccccc3F)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		70690500	82848	0	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057455	82848	0	None	-	1	Human	8.3	pIC50	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		3496768	102515	4	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	0	1	4	2.9	CN1CCc2cc3c(c4c2C1Cc1cccc(O)c1-4)OCO3	10.1021/jm060959i
		CHEMBL258370	102515	4	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	0	1	4	2.9	CN1CCc2cc3c(c4c2C1Cc1cccc(O)c1-4)OCO3	10.1021/jm060959i
		10154	148907	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		CHEMBL388342	148907	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		10154	148907	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL388342	148907	59	None	-58	4	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		9981671	21313	0	None	-	1	Rat	6.4	pIC50	=	6.4	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	459	7	1	9	3.1	COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
		CHEMBL12028	21313	0	None	-	1	Rat	6.4	pIC50	=	6.4	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	459	7	1	9	3.1	COc1ccccc1N1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
		121852	16938	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL11592	16938	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL301060	16938	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10251234	18017	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178932	18017	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50530	18017	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10047322	103915	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL26783	103915	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		CHEMBL50993	103915	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	412	8	0	4	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2ccccc2C1	10.1021/jm00038a007
		10251673	106266	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL283207	106266	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL52396	106266	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	422	9	0	5	3.8	CCCN(CCCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10070029	172196	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL423841	172196	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL54089	172196	0	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	408	8	0	5	3.4	CCCN(CCCN1C(=O)c2ccccc2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10265863	200103	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
		CHEMBL52438	200103	0	None	-	0	Bovine	4.4	pIC50	=	4.4	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	283	5	0	2	4.3	CCCN(CCC)C1COc2ccc3ccccc3c2C1	10.1021/jm00038a007
		121852	16938	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL11592	16938	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		CHEMBL301060	16938	7	None	-	1	Bovine	4.4	pIC50	=	4.4	Binding	Displacement of [3H]raclopride from Dopamine receptor D1 of calf striatumDisplacement of [3H]raclopride from Dopamine receptor D1 of calf striatum	ChEMBL	442	9	0	5	4.2	CCCN(CCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm950861w
		2247	7293	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	7293	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	7293	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	7293	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	7293	81	None	-61	42	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		134551	7146	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	7146	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	7146	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	7146	27	None	-28	21	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		146025811	178540	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4467483	178540	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		146025811	178540	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4467483	178540	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1c(Br)ccc3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		5353853	24758	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	24758	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	24758	47	None	-19	15	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		10498684	38413	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	359	3	2	2	3.6	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL14048	38413	0	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	359	3	2	2	3.6	CN1C[C@H](CNC(=O)c2ccccc2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		71474079	150042	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3896731	150042	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		2337	10030	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	10030	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	10030	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	10030	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	10030	77	None	-53	62	Human	6.4	pIC50	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		11016	210386	38	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	173	3	0	1	0.0	O=P(N1CC1)(N1CC1)N1CC1	10.1021/jm980284m
		CHEMBL670	210386	38	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	173	3	0	1	0.0	O=P(N1CC1)(N1CC1)N1CC1	10.1021/jm980284m
		228	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		33	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		6005	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		CHEMBL53	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		DB00714	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/s0960-894x(01)00076-2
		228	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		33	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		6005	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		CHEMBL53	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		DB00714	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00164a022
		332915	36491	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	240	0	1	1	3.1	C[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL13866	36491	5	None	-	0	Rat	5.4	pIC50	=	5.4	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	240	0	1	1	3.1	C[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		10712649	125985	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		CHEMBL343282	125985	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	346	2	1	3	4.7	CC1(C)CN(C2CC(c3ccsc3)c3ccc(Cl)cc32)CCN1	10.1021/jm00022a004
		5353432	104271	89	None	-1	3	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
		CHEMBL270299	104271	89	None	-1	3	Human	5.4	pIC50	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
		44323870	118368	0	None	3	4	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		CHEMBL328246	118368	0	None	3	4	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		228	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		33	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		6005	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		CHEMBL53	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		DB00714	7233	28	None	-30	23	Rat	6.4	pIC50	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		9864292	36881	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL138964	36881	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3c(Cl)cccc32)CC1(C)C	10.1021/jm00022a004
		70682088	82843	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057446	82843	0	None	-	1	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		14004813	66058	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	307	3	0	2	4.1	COc1cccc2c1CC1CCCN(Cc3ccccc3)C1C2	10.1016/s0960-894x(01)00076-2
		CHEMBL170475	66058	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranesInhibition of binding of [3H]SCH-23390 to Dopamine receptor D1 in rat striatal membranes	ChEMBL	307	3	0	2	4.1	COc1cccc2c1CC1CCCN(Cc3ccccc3)C1C2	10.1016/s0960-894x(01)00076-2
		CHEMBL1200633	215379	3	None	-7	8	Human	5.3	pIC50	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		44269057	38117	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	412	2	3	3	3.4	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL14020	38117	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	412	2	3	3	3.4	CC(=O)NC(=S)NC[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		71110293	150157	0	None	6	3	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	150157	0	None	6	3	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		2389	10104	118	None	-489	66	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	10104	118	None	-489	66	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	10104	118	None	-489	66	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	10104	118	None	-489	66	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	10104	118	None	-489	66	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		44358098	126062	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	292	2	0	2	3.5	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
		CHEMBL343820	126062	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	292	2	0	2	3.5	CN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
		133381	102369	9	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	4	2.8	COc1c2c3c(c4c1OCO4)-c1ccccc1C[C@H]3NCC2	10.1021/jm060959i
		CHEMBL257745	102369	9	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	4	2.8	COc1c2c3c(c4c1OCO4)-c1ccccc1C[C@H]3NCC2	10.1021/jm060959i
		71110293	150157	0	None	6	3	Human	6.3	pIC50	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	150157	0	None	6	3	Human	6.3	pIC50	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		71474026	161078	0	None	1	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
		CHEMBL3986624	161078	0	None	1	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
		45482789	205704	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		CHEMBL584554	205704	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	428	4	2	2	4.5	CCN(CC)C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C(=O)Nc2ccccc2)C1	10.1016/j.bmcl.2009.09.002
		5024	126028	25	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	297	3	0	3	3.3	COc1cc2c(cc1OC)C(c1ccccc1)CN(C)CC2	10.1021/jm980156y
		CHEMBL343569	126028	25	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	297	3	0	3	3.3	COc1cc2c(cc1OC)C(c1ccccc1)CN(C)CC2	10.1021/jm980156y
		10742	10389	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
		1225	10389	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
		CHEMBL35354	10389	31	None	2	8	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00086a016
		13154762	109887	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		CHEMBL307717	109887	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	328	2	0	2	3.8	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1	10.1021/jm00022a004
		6603820	102549	19	None	1	12	Rat	8.3	pIC50	=	8.3	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		CHEMBL25856	102549	19	None	1	12	Rat	8.3	pIC50	=	8.3	Binding	Tested for its affinity towards Dopamine receptor D1 in rat striatal membraneTested for its affinity towards Dopamine receptor D1 in rat striatal membrane	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00041a025
		10617001	37929	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	1	2	4.4	Cc1ccc2c(c1)C(N1CCNC(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL140032	37929	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	338	2	1	2	4.4	Cc1ccc2c(c1)C(N1CCNC(C)(C)C1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		6852376	98374	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		CHEMBL1467585	98374	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		CHEMBL24077	98374	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		CHEMBL503958	98374	13	None	-4	5	Rat	7.3	pIC50	=	7.3	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00086a016
		11794523	37011	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	385	2	0	2	5.7	CCN1CCc2c(sc3ccccc23)C(c2cccc(Br)c2)C1	10.1021/jm980156y
		CHEMBL139081	37011	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	385	2	0	2	5.7	CCN1CCc2c(sc3ccccc23)C(c2cccc(Br)c2)C1	10.1021/jm980156y
		10712993	125526	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	352	3	0	4	4.8	CCN1CCc2c(sc3ccccc23)C(c2cccc([N+](=O)[O-])c2)C1	10.1021/jm980156y
		CHEMBL341805	125526	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	352	3	0	4	4.8	CCN1CCc2c(sc3ccccc23)C(c2cccc([N+](=O)[O-])c2)C1	10.1021/jm980156y
		10251234	18017	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1178932	18017	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL50530	18017	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	414	9	0	5	3.3	CCCN(CCCCN1C(=O)C2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10364722	105861	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	105861	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	105861	0	None	-	1	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10072866	204254	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51561	204254	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL56990	204254	0	None	-	0	Bovine	4.3	pIC50	=	4.3	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	458	9	0	6	3.3	CCCN(CCCCN1C(=O)c2ccccc2S1(=O)=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		11099480	195924	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1ccc2c(c1O)Oc1c(OC)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL510777	195924	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1ccc2c(c1O)Oc1c(OC)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		44370629	57833	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
		CHEMBL157879	57833	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00164a022
		10246432	20573	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL1195595	20573	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		CHEMBL554950	20573	2	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	255	7	1	2	3.7	CCCN(CCC)CCc1ccc(Cl)c(O)c1	10.1021/jm00101a018
		44379650	127535	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		CHEMBL355107	127535	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		10574585	34198	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL136822	34198	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	428	4	1	3	5.0	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		13154795	35673	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	4	1	3	3.3	Cc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL137954	35673	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	354	4	1	3	3.3	Cc1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		10582557	201509	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	309	4	0	3	4.0	CCCN1CCc2cc3c(cc2[C@@H]1Cc1ccccc1)OCO3	10.1021/jm001128u
		CHEMBL53520	201509	0	None	-	0	Rat	4.3	pIC50	=	4.3	Binding	Inhibition of [3H]-SCH- 23390 binding to the rat striatal membranesInhibition of [3H]-SCH- 23390 binding to the rat striatal membranes	ChEMBL	309	4	0	3	4.0	CCCN1CCc2cc3c(cc2[C@@H]1Cc1ccccc1)OCO3	10.1021/jm001128u
		11795296	33540	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136260	33540	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	3	0	2	5.9	CC(C)N1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		10424479	115645	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	293	2	1	2	4.1	CCCN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
		CHEMBL321040	115645	1	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	293	2	1	2	4.1	CCCN1Cc2ccccc2[C@@H]2c3cc(O)ccc3CC[C@H]21	10.1021/jm00002a013
		10923047	23281	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@@H]2CNC3	10.1021/jm0101545
		CHEMBL123642	23281	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1[C@@H]2CNC3	10.1021/jm0101545
		1971	9641	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	9641	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	9641	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	9641	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	9641	38	None	-8	30	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		44312870	211356	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		CHEMBL73082	211356	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		44323876	213361	0	None	2	4	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		CHEMBL88870	213361	0	None	2	4	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00164a053
		135	9310	43	None	-91	56	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	9310	43	None	-91	56	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	9310	43	None	-91	56	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	9310	43	None	-91	56	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	9310	43	None	-91	56	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		10828627	109941	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm991005d
		CHEMBL308090	109941	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm991005d
		15521599	211317	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm991005d
		CHEMBL72794	211317	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm991005d
		10828627	109941	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm9704457
		CHEMBL308090	109941	20	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3ccccc3Nc3ccc(O)cc32)CC1	10.1021/jm9704457
		15521599	211317	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm9704457
		CHEMBL72794	211317	9	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1ccccc1N2	10.1021/jm9704457
		10264174	16460	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@H]21	10.1021/jm00002a013
		CHEMBL113053	16460	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	251	0	2	2	2.9	Oc1cccc2c1CC[C@H]1NCc3ccccc3[C@H]21	10.1021/jm00002a013
		70692656	82850	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057457	82850	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70692656	82850	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057457	82850	0	None	5	2	Human	7.3	pIC50	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		10031670	19236	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
		CHEMBL1186148	19236	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
		CHEMBL451734	19236	1	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	610	9	2	8	6.5	COc1cc2c(cc1O)[C@H](Cc1ccc(Oc3cc(C[C@@H]4c5cc(O)c(OC)cc5CCN4C)ccc3OC)cc1)N(C)CC2	10.1021/np50087a016
		44370651	53524	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1c(Cl)ccc(O)c1-3	10.1021/jm00164a022
		CHEMBL153960	53524	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1c(Cl)ccc(O)c1-3	10.1021/jm00164a022
		3561	25849	39	None	-1	11	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	25849	39	None	-1	11	Human	6.3	pIC50	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		14137099	179470	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
		CHEMBL450147	179470	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
		CHEMBL507970	179470	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	638	11	0	8	7.1	COc1cc2c(cc1OC)[C@H](Cc1ccc(OC)c(Oc3ccc(C[C@@H]4c5cc(OC)c(OC)cc5CCN4C)cc3)c1)N(C)CC2	10.1021/np50087a016
		44269131	37684	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	381	2	2	4	3.2	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL13979	37684	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	381	2	2	4	3.2	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		71041800	169520	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	290	7	3	6	2.2	CCC[C@@H](CCO)Nc1nc(N)nc2cc(OC)ccc12	10.1021/acs.jmedchem.8b00643
		CHEMBL4171368	169520	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	290	7	3	6	2.2	CCC[C@@H](CCO)Nc1nc(N)nc2cc(OC)ccc12	10.1021/acs.jmedchem.8b00643
		44285013	160519	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	319	7	0	1	5.4	C(=C\C1CCCN(CCCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		CHEMBL39818	160519	0	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	319	7	0	1	5.4	C(=C\C1CCCN(CCCCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		1042	8362	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	8362	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	8362	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	8362	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	8362	23	None	-204	17	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		10693049	126146	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	412	2	0	2	6.0	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCCC2	10.1021/jm00022a004
		CHEMBL344426	126146	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	412	2	0	2	6.0	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCCC2	10.1021/jm00022a004
		10810927	126074	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		CHEMBL343922	126074	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	398	2	0	2	5.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC12CCCC2	10.1021/jm00022a004
		146299	180156	8	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL452776	180156	8	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	313	1	2	5	3.0	COc1cc2c(cc1O)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		44267790	22295	0	None	-	1	Rat	6.2	pIC50	=	6.2	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	431	6	1	10	1.9	Cc1sc2nc(SCCCN3CCN(c4ncccn4)CC3)n(N)c(=O)c2c1C	10.1021/jm950866t
		CHEMBL12177	22295	0	None	-	1	Rat	6.2	pIC50	=	6.2	Binding	In vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]SCH-23390 binding to Dopamine receptor D1 in rat striatal membrane	ChEMBL	431	6	1	10	1.9	Cc1sc2nc(SCCCN3CCN(c4ncccn4)CC3)n(N)c(=O)c2c1C	10.1021/jm950866t
		118731187	124957	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	613	10	3	7	6.1	CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(F)cn4)n(C)c3c2)ccc1/C=C/C(=O)O	10.1016/j.bmcl.2014.12.078
		CHEMBL3408841	124957	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	613	10	3	7	6.1	CCOc1nc(NC(=O)C(C)(C)NC(=O)c2ccc3c(C4CCCC4)c(-c4ccc(F)cn4)n(C)c3c2)ccc1/C=C/C(=O)O	10.1016/j.bmcl.2014.12.078
		10092409	18818	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1183479	18818	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL299561	18818	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	400	9	0	4	3.7	CCCN(CCCCN1CC2CCCC2C1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10095594	19140	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL1185501	19140	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL417550	19140	0	None	-	0	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	456	10	0	5	4.6	CCCN(CCCCCN1C(=O)CC2(CCCC2)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10364722	105861	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL280608	105861	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL51888	105861	0	None	-	1	Bovine	4.2	pIC50	=	4.2	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	418	9	1	5	3.0	CCCN(CCNS(=O)(=O)c1ccc(C)cc1)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL3215298	218010	13	None	-6	2	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(C=C[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(C=C[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		14901811	20309	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1193777	20309	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL545240	20309	6	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	155	2	2	2	1.0	NCCc1ccc(F)c(O)c1	10.1021/jm00171a014
		10809333	33964	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136630	33964	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		4189	213701	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	213701	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	213701	96	None	-25	34	Human	5.2	pIC50	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		16104	168696	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00130a006
		CHEMBL415300	168696	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00130a006
		16104	168696	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00164a053
		CHEMBL415300	168696	19	None	-1	5	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00164a053
		44285030	139268	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	291	5	0	1	4.7	C(=C\C1CCCN(CCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		CHEMBL36979	139268	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.Binding affinity at dopamine D1 receptor in rat striatum by [3H]SCH-22390 displacement.	ChEMBL	291	5	0	1	4.7	C(=C\C1CCCN(CCc2ccccc2)C1)\c1ccccc1	10.1016/S0960-894X(97)00253-9
		23930365	102422	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c3c(c1OC)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1021/jm060959i
		CHEMBL257957	102422	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c3c(c1OC)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1021/jm060959i
		44370725	126330	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(Cl)c(O)c1-3	10.1021/jm00164a022
		CHEMBL345907	126330	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	285	0	1	2	3.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(Cl)c(O)c1-3	10.1021/jm00164a022
		9954899	211242	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL72292	211242	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		9954899	211242	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm9704457
		CHEMBL72292	211242	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3ccccc3Nc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm9704457
		167715	9651	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		969	9651	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		CHEMBL225230	9651	14	None	-954	5	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00174a002
		71109986	157412	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
		CHEMBL3955446	157412	0	None	-	1	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
		9904738	108433	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	309	2	2	3	3.8	CCCN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
		CHEMBL299161	108433	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	309	2	2	3	3.8	CCCN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
		13154798	33543	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	382	5	1	3	4.1	CC(C)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL136262	33543	0	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	382	5	1	3	4.1	CC(C)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		10026300	174613	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	441	2	0	7	3.3	CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		CHEMBL430798	174613	17	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	441	2	0	7	3.3	CN1CCN(C2=Nc3ccccc3Oc3ccc(OS(=O)(=O)C(F)(F)F)cc32)CC1	10.1021/jm991005d
		10409038	92017	0	None	-41	4	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL225853	92017	0	None	-41	4	Rat	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		3081681	105290	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	compound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissuecompound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissue	ChEMBL	442	6	0	7	3.4	O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1	10.1021/jm00107a028
		CHEMBL276175	105290	4	None	-	0	Rat	5.2	pIC50	=	5.2	Binding	compound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissuecompound was measured as affinity for dopamine receptor D1 labeled with [3H]-SCH- 23390 radioligand in striatum tissue	ChEMBL	442	6	0	7	3.4	O=C1CC2(CCCC2)CC(=O)N1OCCCN1CCN(c2nsc3ccccc23)CC1	10.1021/jm00107a028
		5249490	21930	1	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1C2CNC3	10.1021/jm0101545
		CHEMBL120995	21930	1	None	-	0	Rat	7.2	pIC50	=	7.2	Binding	In vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membraneIn vitro inhibition of [125I]SCH-23982 binding to Dopamine receptor D1 of rat striatal membrane	ChEMBL	253	0	3	3	2.2	Oc1ccc2c(c1O)Cc1cccc3c1C2CNC3	10.1021/jm0101545
		2105	9828	37	None	-123	32	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	9828	37	None	-123	32	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	9828	37	None	-123	32	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	9828	37	None	-123	32	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	9828	37	None	-123	32	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		70690499	82846	0	None	9	2	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057453	82846	0	None	9	2	Human	7.2	pIC50	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
		160597	161854	30	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	3	2.8	c1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
		CHEMBL401798	161854	30	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	3	2.8	c1ccc2c(c1)C[C@H]1NCCc3cc4c(c-2c31)OCO4	10.1021/jm060959i
		70682090	82844	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057451	82844	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70682090	82844	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057451	82844	0	None	-1	2	Human	6.2	pIC50	=	6.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		3158	63041	27	None	-2398	20	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	63041	27	None	-2398	20	Human	6.2	pIC50	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		2601	10552	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		443951	10552	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		56	10552	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		CHEMBL73151	10552	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		DB13399	10552	33	None	-	21	Rat	7.2	pIC50	=	7.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm00130a008
		13154822	37264	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	418	5	1	5	2.4	CS(=O)(=O)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		CHEMBL139304	37264	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	418	5	1	5	2.4	CS(=O)(=O)c1ccc2c(c1)C(N1CCN(CCO)CC1)CC2c1ccc(F)cc1	10.1021/jm00022a004
		6603820	102549	19	None	1	12	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		CHEMBL25856	102549	19	None	1	12	Rat	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00002a013
		71474025	152105	0	None	131	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3913343	152105	0	None	131	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		11539632	77336	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		CHEMBL194837	77336	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	447	8	1	5	4.8	Cc1cc(OCCN(C)C)nc2ccc(NC(=O)COc3ccc(Cl)cc3Cl)cc12	10.1021/jm050103y
		44354823	31346	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	241	1	1	2	2.2	C#CCN1CCCC2Cc3c(O)cccc3CC21	10.1021/jm980284m
		CHEMBL134273	31346	0	None	-	0	Rat	6.2	pIC50	=	6.2	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	241	1	1	2	2.2	C#CCN1CCCC2Cc3c(O)cccc3CC21	10.1021/jm980284m
		16038374	101122	95	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptorDisplacement of [3H]SCH-23390 from dopamine D1 receptor	ChEMBL	357	5	1	4	4.9	COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1	10.1073/pnas.0611364104
		CHEMBL250699	101122	95	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptorDisplacement of [3H]SCH-23390 from dopamine D1 receptor	ChEMBL	357	5	1	4	4.9	COc1cc(NC(=O)c2ccc(-c3ccc(Cl)cc3)o2)cc(OC)c1	10.1073/pnas.0611364104
		10571551	123345	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	375	2	0	2	6.2	CCN1CCc2c(sc3ccccc23)C(c2ccc(Cl)c(Cl)c2)C1	10.1021/jm980156y
		CHEMBL336437	123345	0	None	-	0	Rat	4.2	pIC50	=	4.2	Binding	Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390Relative affinity for Dopamine receptor D1 in striatum using [3H]SCH-23390	ChEMBL	375	2	0	2	6.2	CCN1CCc2c(sc3ccccc23)C(c2ccc(Cl)c(Cl)c2)C1	10.1021/jm980156y
		135398745	9688	112	None	-26	65	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	9688	112	None	-26	65	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	9688	112	None	-26	65	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	9688	112	None	-26	65	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		49836386	25322	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	253	2	1	2	3.2	CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1	10.1021/jm100515z
		CHEMBL1275709	25322	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Binding affinity to dopamine D1Binding affinity to dopamine D1	ChEMBL	253	2	1	2	3.2	CN(C)[C@@H]1CC[C@H](c2c[nH]c3ccc(C#N)cc23)C1	10.1021/jm100515z
		44269142	38903	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL14089	38903	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	437	2	2	4	4.5	CN1C[C@H](C(=O)Nc2ccc(Cl)nn2)C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		15115475	33618	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	322	4	1	3	2.9	OCCN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
		CHEMBL136333	33618	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	322	4	1	3	2.9	OCCN1CCN(C2CC(c3ccccc3)c3ccccc32)CC1	10.1021/jm00022a004
		12441	57865	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm00164a022
		CHEMBL157912	57865	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm00164a022
		44269091	105197	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		CHEMBL275539	105197	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	394	2	2	3	3.0	CN1C[C@H](CN2CC(=O)NC2=O)C[C@@H]2c3cc(C(C)(C)C)cc4[nH]cc(c34)C[C@H]21	10.1016/s0960-894x(98)00166-8
		44312604	211230	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	338	1	0	2	4.6	CC1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		CHEMBL72220	211230	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	338	1	0	2	4.6	CC1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00130a006
		133	9274	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	9274	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	9274	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	9274	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	9274	52	None	-30	43	Human	7.1	pIC50	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		12441	57865	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm060959i
		CHEMBL157912	57865	21	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	1	1	5	2.9	COc1ccc2c(c1O)-c1c3c(cc4c1[C@H](C2)N(C)CC4)OCO3	10.1021/jm060959i
		5018	10322	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		943	10322	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		946	10322	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		CHEMBL13668	10322	13	None	2	10	Human	6.1	pIC50	=	6.1	Binding	[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.[35S]GTPγS Binding Assay: For detecting the agonism action of the compounds, the [35S]GTPγS binding assay was performed at 30° C. for 40 mins in reaction buffer containing 50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, 100 mM NaCl and 1 mM (DL)-dithiothreitol (DTT). The assay mixture (200 μL) contained 30 μg of membraneprotein, 0.1 nM [35S]GTPγS, and 40 μM guanosine triphosphate (GDP) with various concentration of the compound. The D1 receptor agonist SKF38393 and sntagonist SCH23390 were used for reference. Non specific binding was measured in the presence of 100 μM 50-guanylimidodiphosphate (Gpp(NH)p). The reaction was terminated by adding 3 mL of ice-cold washing buffer (50 mM Tris, pH 7.5, 5 mM MgCl2, 1 mM EDTA, and 100 mM NaCl) and was rapidly filtered with GF/C glass fiber filters (Whatman) and rinsed for three times.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		135686415	211355	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm991005d
		CHEMBL73074	211355	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm991005d
		135686415	211355	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm9704457
		CHEMBL73074	211355	1	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	322	1	1	5	3.1	COc1ccc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm9704457
		3294	8787	111	None	-	44	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		71360	8787	111	None	-	44	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		87	8787	111	None	-	44	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		CHEMBL14376	8787	111	None	-	44	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		DB04946	8787	111	None	-	44	Mouse	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	ChEMBL	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	10.1021/jm00007a009
		10144	145188	46	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	275	0	0	4	3.2	O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3	10.1021/jm060959i
		CHEMBL37736	145188	46	None	-	0	Rat	4.1	pIC50	=	4.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	275	0	0	4	3.2	O=C1c2ccccc2-c2c3c(cc4ccnc1c24)OCO3	10.1021/jm060959i
		44269092	35859	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	296	0	1	1	4.4	C[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL13811	35859	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	296	0	1	1	4.4	C[C@@H]1C[C@@H]2c3ccc(C(C)(C)C)c4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		11059058	16863	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
		CHEMBL115444	16863	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
		71110287	153103	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL3921127	153103	0	None	-	1	Human	6.1	pIC50	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		448537	167029	89	None	-28	25	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	167029	89	None	-28	25	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		44312605	211214	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
		CHEMBL72162	211214	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	336	1	0	2	4.5	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1021/jm00164a053
		13720693	106449	4	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00086a016
		CHEMBL284473	106449	4	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Displacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatumDisplacement of [3H]-SCH- 23390 (0.3 nM) from dopamine receptor D1 in crude membrane fraction of rat brain corpus striatum	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00086a016
		71109897	94288	0	None	7	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
		CHEMBL2334893	94288	0	None	7	2	Human	8.1	pIC50	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
		10478809	171657	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
		CHEMBL422067	171657	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.The compound was tested for the binding affinity against Dopamine receptor D1 activity is expressed as IC50 values.	ChEMBL	374	4	1	3	3.7	OCCN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00022a004
		10787201	35505	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	4	0	2	5.9	CCC1(CC)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
		CHEMBL137805	35505	0	None	-	0	Rat	8.1	pIC50	=	8.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	400	4	0	2	5.9	CCC1(CC)CN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CCN1C	10.1021/jm00022a004
		44354809	123320	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	3.8	COc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
		CHEMBL336274	123320	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranesDisplacement of [3H]-SCH- 23390 from Dopamine receptor D1 of rat striatal membranes	ChEMBL	383	3	0	2	3.8	COc1cccc2c1CC1CCCN(C/C=C/I)C1C2	10.1021/jm980284m
		100	10577	58	None	-16	54	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		2637	10577	58	None	-16	54	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		5452	10577	58	None	-16	54	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		CHEMBL479	10577	58	None	-16	54	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		DB00679	10577	58	None	-16	54	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brainDisplacement of [3H]cis-flupenthixol from Dopamine receptor D1 in rat brain	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	10.1021/jm00397a032
		681	8247	72	None	-97	38	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		940	8247	72	None	-97	38	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		947	8247	72	None	-97	38	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		CHEMBL59	8247	72	None	-97	38	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		DB00988	8247	72	None	-97	38	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00168a034
		442203	181337	5	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1cc2c(cc1OC)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL455633	181337	5	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	1	5	3.3	COc1cc2c(cc1OC)Oc1c(O)ccc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		10504100	54514	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membrane	ChEMBL	458	7	1	8	4.2	COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
		CHEMBL154787	54514	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membraneIn vitro inhibitory concentration against radioligand [3H]spiperone binding to Dopamine receptor D2 in rat striatal membrane	ChEMBL	458	7	1	8	4.2	COc1ccccc1C1CCN(CCCSc2nc3sc(C)c(C)c3c(=O)n2N)CC1	10.1021/jm950866t
		14901825	19860	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL1190275	19860	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		CHEMBL540546	19860	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	Compound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranesCompound was evaluated for the inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 of rat striatal membranes	ChEMBL	287	7	1	2	3.6	CCN(CCc1ccccc1)CCc1ccc(F)c(O)c1	10.1021/jm00171a014
		10024943	104165	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL26975	104165	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		CHEMBL52485	104165	0	None	-	1	Bovine	4.1	pIC50	=	4.1	Binding	Binding affinity towards dopamine receptor D1 in calf striatumBinding affinity towards dopamine receptor D1 in calf striatum	ChEMBL	416	9	0	5	3.7	CCCN(CCCCN1C(=O)CC(C)(C)CC1=O)C1COc2cccc(OC)c2C1	10.1021/jm00038a007
		10406315	200104	0	None	-	2	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	361	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(Cl)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		CHEMBL524439	200104	0	None	-	2	Rat	7.1	pIC50	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membraneDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane	ChEMBL	361	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(Cl)c(O)c(OC)c3-2)CCN1C	10.1021/np990433j
		146025813	182366	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		CHEMBL4579687	182366	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Antagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assayAntagonist activity at C-terminal RLuc8-fused D1R (unknown origin) transfected in human HEK293T cells co-expressing N-terminal Venus-tagged beta-arrestin2 assessed as increase in beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay	ChEMBL	373	2	0	3	4.2	COc1ccc2c(c1OC)-c1ccc(Br)c3c1[C@@H](C2)N(C)CC3	10.1021/acsmedchemlett.9b00575
		44370706	54746	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1cc(Br)cc(O)c1-3	10.1021/jm00164a022
		CHEMBL154989	54746	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@H]1Cc1cc(Br)cc(O)c1-3	10.1021/jm00164a022
		10409556	169151	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	414	8	1	5	3.3	COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1016/0960-894X(96)00174-6
		CHEMBL416523	169151	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390Binding affinity towards Dopamine receptor D1 by displacement of [3H]SCH-23,390	ChEMBL	414	8	1	5	3.3	COc1cccc2c1CC(CNCCCCN1C(=O)CC3(CCCC3)CC1=O)CO2	10.1016/0960-894X(96)00174-6
		15657207	213116	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	287	2	2	2	3.7	CNC1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00069a013
		CHEMBL87321	213116	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligandBinding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23,390 as radioligand	ChEMBL	287	2	2	2	3.7	CNC1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00069a013
		44269058	38140	0	None	-	1	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		CHEMBL14022	38140	0	None	-	1	Rat	6.1	pIC50	=	6.1	Binding	Displacement of [3H]SCH-23390 from D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from D1 receptor in rat striatum	ChEMBL	425	6	2	4	2.6	CCNC(=O)N(CCCN(C)C)C(=O)[C@@H]1C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1	10.1016/s0960-894x(98)00166-8
		1016	10519	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	10519	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	10519	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	10519	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	10519	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	10519	78	None	-29	35	Human	5.1	pIC50	=	5.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		44370645	126340	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
		CHEMBL346017	126340	0	None	-	0	Rat	5.1	pIC50	=	5.1	Binding	In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.In vitro binding affinity towards rat Dopamine receptor D1 by [3H]SCH-23390 displacement.	ChEMBL	329	0	1	2	3.9	CN1CCc2cccc3c2[C@@H]1Cc1c(Br)ccc(O)c1-3	10.1021/jm00164a022
		1530	8963	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	8963	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	8963	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	8963	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	8963	50	None	-53	21	Human	6.1	pIC50	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		10522247	33504	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136235	33504	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	356	2	0	2	4.6	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(F)cc32)CC1(C)C	10.1021/jm00022a004
		16103	211417	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00130a006
		CHEMBL73538	211417	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligandBinding activity against dopamine D1 receptor in rat brain, using [3H]SCH-23390 as the radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00130a006
		16103	211417	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00164a053
		CHEMBL73538	211417	47	None	-2	4	Rat	6.1	pIC50	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brainBinding affinity against Dopamine receptor D1 using [3H]-SCN 23390 in rat brain	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00164a053
		71454427	85295	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		CHEMBL2111937	85295	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3cc(Cl)ccc32)CC1	10.1021/jm00022a004
		44329358	114301	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		CHEMBL318714	114301	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	344	2	0	2	4.3	CN1CCN(C2CC(c3ccc(F)cc3)c3ccc(Cl)cc32)CC1	10.1021/jm00072a006
		10833129	34263	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3cccc(F)c3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		CHEMBL136873	34263	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.Binding affinity for dopamine receptor D1, activity is expressed as IC50 values.	ChEMBL	372	2	0	2	5.1	CN1CCN(C2CC(c3cccc(F)c3)c3ccc(Cl)cc32)CC1(C)C	10.1021/jm00022a004
		15648963	23666	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	340	2	0	2	5.1	CN1CC=C(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1	10.1021/jm00072a006
		CHEMBL12507	23666	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Binding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranesBinding affinity towards dopamine receptor D1 by displacement of [3H]-SCH- radioligand in rat striatal membranes	ChEMBL	340	2	0	2	5.1	CN1CC=C(c2cn(-c3ccc(F)cc3)c3ccc(Cl)cc23)CC1	10.1021/jm00072a006
		70690500	82848	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		CHEMBL2057455	82848	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		9804849	74230	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
		CHEMBL189118	74230	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibitory concentration against dopamine receptor D1Inhibitory concentration against dopamine receptor D1	ChEMBL	472	8	1	5	5.1	Cc1cc(N(C)CCN(C)C)nc2ccc(NC(=O)/C=C/c3ccc(OC(F)(F)F)cc3)cc12	10.1021/jm050103y
		2812	11551	101	None	-32	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	11551	101	None	-32	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		44584686	19464	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		CHEMBL1187479	19464	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		CHEMBL504303	19464	0	None	-	0	Rat	4.0	pIC50	=	4.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	622	3	2	9	6.1	COc1cc2c3cc1Oc1c(O)c(OC)cc4c1[C@@H](C(=O)c1ccc(O)c(c1)-c1cc(ccc1OC)C[C@H]3N(C)CC2)N(C)CC4	10.1021/np50087a016
		11543723	195878	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
		CHEMBL51017	195878	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Displacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatumDisplacement of [3H]- #NAME? from binding Dopamine receptor D1 in rat striatum	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1021/jm00168a034
		176	7186	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	7186	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	7186	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	7186	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	7186	66	None	-4	31	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		3198	212292	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	212292	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	212292	76	None	-31	34	Human	5.0	pIC50	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		114876	19565	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
		CHEMBL1188090	19565	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
		CHEMBL545783	19565	5	None	-	5	Rat	4.0	pIC50	=	4.0	Binding	Inhibitory activity against [3H]-SCH- 23390 in Rat Striatal membraneInhibitory activity against [3H]-SCH- 23390 in Rat Striatal membrane	ChEMBL	283	8	1	2	3.9	CCCN(CCc1ccccc1)CCc1cccc(O)c1	10.1021/jm00101a018
		135515198	111527	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		CHEMBL310712	111527	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		135515198	111527	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		CHEMBL310712	111527	8	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	440	2	1	7	3.3	CN1CCN(C2=Nc3cc(OS(=O)(=O)C(F)(F)F)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		134	9292	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	9292	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	9292	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	9292	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	9292	24	None	-263	67	Human	6.0	pIC50	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		11778475	170074	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3ccc(O)c(O)c3CC[C@H]21	10.1021/jm00002a013
		CHEMBL418791	170074	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 by using [3H]SCH-23390 as radioligand	ChEMBL	281	0	2	3	3.0	CN1Cc2ccccc2[C@@H]2c3ccc(O)c(O)c3CC[C@H]21	10.1021/jm00002a013
		66572162	82470	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	363	6	1	3	5.2	OC(CCN1CC=C(Cc2ccccc2)CC1)c1cc2ccccc2s1	10.1016/j.ejmech.2012.04.030
		CHEMBL2047561	82470	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	363	6	1	3	5.2	OC(CCN1CC=C(Cc2ccccc2)CC1)c1cc2ccccc2s1	10.1016/j.ejmech.2012.04.030
		10907460	16600	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		CHEMBL113956	16600	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of human dopamine receptor D1Inhibition of human dopamine receptor D1	ChEMBL	521	11	1	3	5.8	CCOc1ccc(CCNC(=O)N2CCN(CCCC(c3ccc(F)cc3)c3ccc(F)cc3)CC2)cc1	10.1021/jm010878g
		25053021	116449	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		CHEMBL322574	116449	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatum membraneBinding affinity against Dopamine receptor D1 from rat brain corpus striatum membrane	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00174a002
		25053021	116449	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL322574	116449	0	None	-	0	Rat	6.0	pIC50	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	373	2	2	3	4.4	CCCN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		70686343	82847	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057454	82847	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		135508767	210904	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		CHEMBL70377	210904	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Binding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligandBinding affinity towards D1 CNS receptor of rat corpus striatum using [3H]SCH-23390 as radioligand	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm991005d
		13891896	195710	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	297	2	2	4	2.8	COc1c(O)c2c3c(c1OC)CCN[C@@H]3Cc1ccccc1-2	10.1021/jm060959i
		CHEMBL508011	195710	0	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	297	2	2	4	2.8	COc1c(O)c2c3c(c1OC)CCN[C@@H]3Cc1ccccc1-2	10.1021/jm060959i
		135508767	210904	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		CHEMBL70377	210904	21	None	-	0	Rat	5.0	pIC50	=	5.0	Binding	Inhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatumInhibitory binding of [3H]SCH-23390 to Dopamine receptor D1 in membranes from rat corpus striatum	ChEMBL	308	0	2	5	2.8	CN1CCN(C2=Nc3cc(O)ccc3Nc3ccccc32)CC1	10.1021/jm9704457
		3082777	175101	10	None	-	1	Human	9.8	pKd	=	9.8	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2C(c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00119a003
		CHEMBL434215	175101	10	None	-	1	Human	9.8	pKd	=	9.8	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2C(c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00119a003
		164612037	192156	0	None	-144	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	192156	0	None	-144	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		168290235	199747	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	199747	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	199747	0	None	-1513	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		168294767	199798	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	199798	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	199798	0	None	-457	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		168295528	199810	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	199810	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	199810	0	None	-338	20	Human	9.6	pKd	=	9.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		44366049	50229	0	None	-	1	Human	9.6	pKd	=	9.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
		CHEMBL150800	50229	0	None	-	1	Human	9.6	pKd	=	9.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
		2869	10924	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		60	10924	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		60857	10924	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		CHEMBL1185	10924	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		DB00315	10924	89	None	-2	7	Rat	9.5	pKd	=	9.5	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	ChEMBL	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	10.1021/jm00018a016
		3036864	209533	19	None	-2	27	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
		CHEMBL1256645	209533	19	None	-2	27	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
		CHEMBL1814790	209533	19	None	-2	27	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
		CHEMBL62	209533	19	None	-2	27	Human	9.4	pKd	=	9.4	Binding	Ability to inhibit the binding of [3H]-SCH- 23390 to canine striatal membraneAbility to inhibit the binding of [3H]-SCH- 23390 to canine striatal membrane	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00119a003
		129244	125449	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		CHEMBL2114388	125449	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		CHEMBL34170	125449	7	None	-	1	Rat	8.9	pKd	=	8.9	Binding	In vitro binding affinity to the rat striatal homogenateIn vitro binding affinity to the rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		118736406	125734	0	None	3	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	673	16	7	7	2.7	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423404	125734	0	None	3	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	673	16	7	7	2.7	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		16731521	92230	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	630	10	4	5	3.5	CC(C)[C@H](NC(=O)[C@H](CCC1CCCCC1)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		CHEMBL226639	92230	0	None	-	1	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	630	10	4	5	3.5	CC(C)[C@H](NC(=O)[C@H](CCC1CCCCC1)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		118736409	125737	0	None	-1	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	693	16	6	6	3.3	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)c(F)c1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423407	125737	0	None	-1	3	Human	5.9	pKd	=	5.9	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	693	16	6	6	3.3	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)c(F)c1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		6852376	98374	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
		CHEMBL1467585	98374	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
		CHEMBL24077	98374	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
		CHEMBL503958	98374	13	None	-3	5	Human	6.8	pKd	=	6.8	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm950447w
		118736412	125741	0	None	-6	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423410	125741	0	None	-6	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736405	125733	0	None	-9	3	Human	4.8	pKd	=	4.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423403	125733	0	None	-9	3	Human	4.8	pKd	=	4.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736413	125742	0	None	-2	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423411	125742	0	None	-2	2	Human	5.8	pKd	=	5.8	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as high affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		167715	9651	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		969	9651	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		CHEMBL225230	9651	14	None	-194	5	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		1153	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		12668023	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		30026874	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		30026875	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		3341	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		6603851	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		933	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		939	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		985	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL1160786	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL1161520	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL588	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		DB00800	8409	58	None	-32	10	Human	5.7	pKd	=	5.7	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		118736408	125736	0	None	1	3	Human	5.7	pKd	=	5.7	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	696	16	7	6	3.5	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423406	125736	0	None	1	3	Human	5.7	pKd	=	5.7	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	696	16	7	6	3.5	CCCC[C@H](NC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		5311428	106883	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL1744078	106883	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL287504	106883	9	None	-32	2	Rat	6.7	pKd	=	6.7	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		10088113	169056	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL1744079	169056	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL416401	169056	6	None	-4	2	Rat	8.6	pKd	=	8.6	Binding	In vitro binding affinity to the rat striatal homogenate.In vitro binding affinity to the rat striatal homogenate.	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		118736412	125741	0	None	-6	2	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423410	125741	0	None	-6	2	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		681	8247	72	None	-154	38	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		940	8247	72	None	-154	38	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		947	8247	72	None	-154	38	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		CHEMBL59	8247	72	None	-154	38	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		DB00988	8247	72	None	-154	38	Human	5.6	pKd	=	5.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm950447w
		118736402	125730	0	None	-5	4	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	659	11	5	6	2.4	CCCC[C@H](NC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423400	125730	0	None	-5	4	Human	4.6	pKd	=	4.6	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	659	11	5	6	2.4	CCCC[C@H](NC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		1153	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		12668023	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		30026874	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		30026875	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		3341	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		6603851	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		933	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		939	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		985	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL1160786	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL1161520	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		CHEMBL588	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		DB00800	8409	58	None	-32	10	Human	7.6	pKd	=	7.6	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm950447w
		118736404	125732	0	None	-2	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	18	7	7	3.5	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423402	125732	0	None	-2	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	18	7	7	3.5	NCCCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736413	125742	0	None	-2	2	Human	4.5	pKd	=	4.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423411	125742	0	None	-2	2	Human	4.5	pKd	=	4.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes assessed as low affinity constant after 1.5 hrs by scintillation counting analysis	ChEMBL	790	18	6	7	3.3	NCCCC[C@H](NC(=O)[C@H](Cc1ccc(F)c(F)c1)NC(=O)[C@H]1CCCN1C(=O)CCCCCNC(=O)[C@@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736411	125739	0	None	-1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	788	22	7	7	3.8	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423409	125739	0	None	-1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	788	22	7	7	3.8	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		118736407	125735	0	None	1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	17	7	7	3.5	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423405	125735	0	None	1	3	Human	5.5	pKd	=	5.5	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	793	17	7	7	3.5	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		118736403	125731	0	None	-6	3	Human	4.4	pKd	=	4.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	786	22	8	8	3.4	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423401	125731	0	None	-6	3	Human	4.4	pKd	=	4.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	786	22	8	8	3.4	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/j.ejmech.2015.04.052
		10452020	125053	3	None	10	3	Human	6.4	pKd	=	6.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm950447w
		CHEMBL34095	125053	3	None	10	3	Human	6.4	pKd	=	6.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm950447w
		118736410	125738	0	None	-1	3	Human	5.4	pKd	=	5.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	772	17	6	7	3.1	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		CHEMBL3423408	125738	0	None	-1	3	Human	5.4	pKd	=	5.4	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysisDisplacement of [3H]-SCH23390 from dopamine D1 receptor (unknown origin) expressed in sheep striatum membranes after 1.5 hrs by scintillation counting analysis	ChEMBL	772	17	6	7	3.1	CCCC[C@H](NC(=O)CCCCCNC(=O)[C@H]1CC[C@@H]2c3[nH]c4ccccc4c3CCN2C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1C[C@@H](N)C[C@H]1C(N)=O	10.1016/j.ejmech.2015.04.052
		122132	209343	17	None	-87	4	Human	5.3	pKd	=	5.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm950447w
		CHEMBL611801	209343	17	None	-87	4	Human	5.3	pKd	=	5.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm950447w
		1960	9632	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		439260	9632	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		505	9632	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		CHEMBL1437	9632	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		DB00368	9632	67	None	-95	26	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		1028	7079	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		139148732	7079	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		479	7079	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		5816	7079	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		CHEMBL679	7079	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		DB00668	7079	71	None	-91	30	Human	4.3	pKd	=	4.3	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	10.1021/jm950447w
		16731518	149060	0	None	26	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	628	9	4	5	2.5	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		CHEMBL388509	149060	0	None	26	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	628	9	4	5	2.5	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		228	7233	28	None	-35	23	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		33	7233	28	None	-35	23	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		6005	7233	28	None	-35	23	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		CHEMBL53	7233	28	None	-35	23	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		DB00714	7233	28	None	-35	23	Human	6.2	pKd	=	6.2	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm950447w
		16732431	150809	0	None	-34	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	735	11	4	7	3.3	CN1C[C@H](C(=O)N[C@@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCCC(C(N)=O)C2)C=C2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm060947x
		CHEMBL390299	150809	0	None	-34	2	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	735	11	4	7	3.3	CN1C[C@H](C(=O)N[C@@H](Cc2ccc([N+](=O)[O-])cc2)C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)N2CCCC(C(N)=O)C2)C=C2c3cccc4[nH]cc(c34)C[C@H]21	10.1021/jm060947x
		16732899	175484	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		CHEMBL436797	175484	0	None	-	1	Human	6.2	pKd	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		16731520	149129	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		CHEMBL388732	149129	0	None	-	1	Human	5.1	pKd	=	5.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hrDisplacement of [3H]SCH 23390 from dopamine D1 receptor in lamb striatum membrane after 1 hr	ChEMBL	655	10	4	7	2.3	CC(C)[C@H](NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1)C(=O)N[C@@H](Cc1ccc([N+](=O)[O-])cc1)C(=O)N1CCC[C@H]1C(N)=O	10.1021/jm060947x
		5	6927	72	None	-23442	53	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
		5202	6927	72	None	-23442	53	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
		CHEMBL39	6927	72	None	-23442	53	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
		DB08839	6927	72	None	-23442	53	Human	5.0	pKd	=	5.0	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	ChEMBL	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	10.1021/jm950447w
		4350931	176092	44	None	63	7	Rat	10.1	pKi	=	10.1	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
		CHEMBL441618	176092	44	None	63	7	Rat	10.1	pKi	=	10.1	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
		127026236	144896	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		CHEMBL3763331	144896	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		CHEMBL3765893	144896	0	None	1	3	Rat	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	450	8	1	4	3.9	O=C(NCCCN1CCN(C(c2ccc(F)cc2)c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		3036864	209533	19	None	-26	27	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	209533	19	None	-26	27	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	209533	19	None	-26	27	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	209533	19	None	-26	27	Bovine	10.0	pKi	=	10	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		3036864	209533	19	None	-2	27	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
		CHEMBL1256645	209533	19	None	-2	27	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
		CHEMBL1814790	209533	19	None	-2	27	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
		CHEMBL62	209533	19	None	-2	27	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2014.12.045
		3036864	209533	19	None	-2	27	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
		CHEMBL1256645	209533	19	None	-2	27	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
		CHEMBL1814790	209533	19	None	-2	27	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
		CHEMBL62	209533	19	None	-2	27	Human	10.0	pKi	=	10	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm401895u
		3036864	209533	19	None	-2	27	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL1256645	209533	19	None	-2	27	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL1814790	209533	19	None	-2	27	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		CHEMBL62	209533	19	None	-2	27	Human	10.0	pKi	=	10.0	Binding	Binding affinity to human dopamine D1 receptor by radioligand displacement assayBinding affinity to human dopamine D1 receptor by radioligand displacement assay	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.ejmech.2013.01.044
		3036864	209533	19	None	-2	27	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
		CHEMBL1256645	209533	19	None	-2	27	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
		CHEMBL1814790	209533	19	None	-2	27	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
		CHEMBL62	209533	19	None	-2	27	Human	10.0	pKi	=	10.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm2006782
		3036864	209533	19	None	-2	27	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL62	209533	19	None	-2	27	Rat	9.9	pKi	=	9.9	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/s0960-894x(00)00185-2
		11465618	109175	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
		CHEMBL3039528	109175	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
		CHEMBL5191141	109175	23	None	1	19	Human	9.9	pKi	=	9.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2020.127563
		3036864	209533	19	None	-2	27	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
		CHEMBL62	209533	19	None	-2	27	Rat	9.9	pKi	=	9.9	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00391a028
		3036864	209533	19	None	-2	27	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	209533	19	None	-2	27	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	209533	19	None	-2	27	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	209533	19	None	-2	27	Human	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		3036864	209533	19	None	-26	27	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	209533	19	None	-26	27	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	209533	19	None	-26	27	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	209533	19	None	-26	27	Bovine	9.8	pKi	=	9.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		3036864	209533	19	None	-2	27	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1256645	209533	19	None	-2	27	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1814790	209533	19	None	-2	27	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL62	209533	19	None	-2	27	Human	9.8	pKi	=	9.8	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		3036864	209533	19	None	-2	27	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
		CHEMBL1256645	209533	19	None	-2	27	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
		CHEMBL1814790	209533	19	None	-2	27	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
		CHEMBL62	209533	19	None	-2	27	Human	9.7	pKi	=	9.7	Binding	Antagonist activity at dopamine D1 receptor (unknown origin)Antagonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2020.127305
		11154178	207005	0	None	64	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	412	4	1	3	4.6	CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1	10.1016/j.bmcl.2009.12.100
		CHEMBL596824	207005	0	None	64	3	Human	9.7	pKi	=	9.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	412	4	1	3	4.6	CC(=O)N(Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1)C1CCC1	10.1016/j.bmcl.2009.12.100
		162657549	187763	0	None	630	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	355	1	1	3	5.3	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4758723	187763	0	None	630	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	355	1	1	3	5.3	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		46231926	207358	0	None	12	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	446	4	1	4	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL599135	207358	0	None	12	4	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	446	4	1	4	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/OCc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46231992	207422	0	None	398	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	389	1	1	2	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL599528	207422	0	None	398	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	389	1	1	2	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3036864	209533	19	None	-2	27	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL62	209533	19	None	-2	27	Rat	9.7	pKi	=	9.7	Binding	The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.The compound was tested for binding affinity against Dopamine receptor D1 from rat striatal membranes, using [3H]-SCH- 23390 as radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00021a018
		14896355	33606	0	None	10	3	Rat	9.6	pKi	=	9.6	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(Br)c2)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL13632	33606	0	None	10	3	Rat	9.6	pKi	=	9.6	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2cccc(Br)c2)C1	10.1016/s0960-894x(00)00185-2
		1243	10390	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
		944	10390	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
		CHEMBL324017	10390	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	10.1021/jm00115a012
		3038603	108642	8	None	2	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
		CHEMBL300647	108642	8	None	2	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
		3036864	209533	19	None	-2	27	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL1256645	209533	19	None	-2	27	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL1814790	209533	19	None	-2	27	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL62	209533	19	None	-2	27	Human	9.5	pKi	=	9.5	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		3036864	209533	19	None	-2	27	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL62	209533	19	None	-2	27	Rat	9.5	pKi	=	9.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/S0960-894X(00)80155-9
		3036864	209533	19	None	-2	27	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
		CHEMBL1256645	209533	19	None	-2	27	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
		CHEMBL1814790	209533	19	None	-2	27	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
		CHEMBL62	209533	19	None	-2	27	Human	9.5	pKi	=	9.5	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00081a010
		11269330	208272	0	None	34	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	390	1	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL605127	208272	0	None	34	4	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	390	1	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccncc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3039881	181036	10	None	4	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
		CHEMBL45491	181036	10	None	4	3	Human	9.5	pKi	=	9.5	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
		11558055	79927	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL1204122	79927	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL201170	79927	1	None	-1	6	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		3036864	209533	19	None	-2	27	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL1256645	209533	19	None	-2	27	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL1814790	209533	19	None	-2	27	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		CHEMBL62	209533	19	None	-2	27	Human	9.4	pKi	=	9.4	Binding	Displacement of radiolabeled SCH 23390 from human dopamine D1 receptorDisplacement of radiolabeled SCH 23390 from human dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm8007618
		11558055	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		CHEMBL1204122	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		CHEMBL201170	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		11558055	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL1204122	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL201170	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2006.11.093
		11558055	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
		CHEMBL1204122	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
		CHEMBL201170	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmc.2009.08.028
		3036864	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL62	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		11558055	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
		CHEMBL1204122	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
		CHEMBL201170	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm050846j
		14787973	109444	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1cccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)c1	10.1021/jm00170a025
		CHEMBL304535	109444	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1cccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)c1	10.1021/jm00170a025
		3036864	209533	19	None	2	27	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL1256645	209533	19	None	2	27	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL1814790	209533	19	None	2	27	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		CHEMBL62	209533	19	None	2	27	Mouse	9.4	pKi	=	9.4	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00170a025
		3036864	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL62	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		11558055	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
		CHEMBL1204122	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
		CHEMBL201170	79927	1	None	-1	6	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1039/C5MD00258C
		46231993	207186	0	None	562	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	407	1	1	2	5.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL598104	207186	0	None	562	2	Human	9.4	pKi	=	9.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	407	1	1	2	5.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3036864	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
		CHEMBL62	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00128a038
		3036864	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL62	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		3036864	209533	19	None	-2	27	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
		CHEMBL1256645	209533	19	None	-2	27	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
		CHEMBL1814790	209533	19	None	-2	27	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
		CHEMBL62	209533	19	None	-2	27	Human	9.4	pKi	=	9.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00129a006
		3036864	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
		CHEMBL62	209533	19	None	-2	27	Rat	9.4	pKi	=	9.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00118a012
		11595240	146966	0	None	-5	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
		CHEMBL380464	146966	0	None	-5	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2c(ccc(O)c2Cl)CC1	10.1021/jm051237e
		162655154	187552	0	None	204	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4756254	187552	0	None	204	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		44320357	213178	0	None	1202	2	Rat	9.3	pKi	=	9.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL87734	213178	0	None	1202	2	Rat	9.3	pKi	=	9.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	287	2	4	5	2.1	NC[C@@H]1OC(c2cccc(O)c2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		11235174	207160	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL597909	207160	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NS(C)(=O)=O)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		11374299	207387	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	448	5	1	4	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL599282	207387	0	None	11	3	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	448	5	1	4	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C3CCC3)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
		46231588	208040	0	None	12022	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	408	4	1	4	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL603901	208040	0	None	12022	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	408	4	1	4	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(C)(=O)=O)cc2)C1	10.1016/j.bmcl.2009.12.100
		3036864	209533	19	None	-2	27	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
		CHEMBL1256645	209533	19	None	-2	27	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
		CHEMBL1814790	209533	19	None	-2	27	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
		CHEMBL62	209533	19	None	-2	27	Pig	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm0604979
		44439943	100141	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL245570	100141	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2006.11.093
		11465618	109175	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL3039528	109175	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		CHEMBL5191141	109175	23	None	1	19	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	354	2	0	2	4.9	CN1CCN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CC1(C)C	10.1016/j.bmcl.2022.128879
		44439943	100141	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL245570	100141	0	None	-1	4	Human	9.3	pKi	=	9.3	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	306	0	2	2	3.5	CN1CCc2ccccc2Cc2[nH]c3ccc(O)cc3c2CC1	10.1016/j.bmcl.2008.04.081
		86346162	139218	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	433	3	1	4	4.2	Cc1cc(Oc2ncccc2I)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697581	139218	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	433	3	1	4	4.2	Cc1cc(Oc2ncccc2I)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		10088113	169056	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1744079	169056	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL416401	169056	6	None	4	2	Human	9.2	pKi	=	9.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	331	1	1	2	3.8	CN1CCc2cc(Br)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		11488247	207418	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	470	5	1	4	4.5	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL599487	207418	0	None	1	4	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	470	5	1	4	4.5	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(C)S(=O)(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
		46232135	207103	0	None	85	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	428	1	2	2	6.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc5[nH]ccc5c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL597503	207103	0	None	85	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	428	1	2	2	6.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc5[nH]ccc5c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46231994	207187	0	None	5	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	414	1	1	3	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL598105	207187	0	None	5	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	414	1	1	3	5.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(C#N)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46231784	208117	0	None	2	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	329	0	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604314	208117	0	None	2	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	329	0	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46231995	208313	0	None	7	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	434	2	1	4	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL605339	208313	0	None	7	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	434	2	1	4	5.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc([N+](=O)[O-])c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		44268809	105041	0	None	46	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
		CHEMBL274577	105041	0	None	46	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
		24873463	154822	0	None	3467	2	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	557	10	0	5	6.0	O=C(CCCN1CCN2CC3C(CC2C1)c1ccccc1N3CCCC(=O)c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
		CHEMBL393466	154822	0	None	3467	2	Rat	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	557	10	0	5	6.0	O=C(CCCN1CCN2CC3C(CC2C1)c1ccccc1N3CCCC(=O)c1ccc(F)cc1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
		46231645	207130	0	None	776	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	518	6	1	3	7.2	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(Cc3ccccc3)c3ccc(F)cc3F)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL597702	207130	0	None	776	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	518	6	1	3	7.2	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CN(Cc3ccccc3)c3ccc(F)cc3F)cc2)C1	10.1016/j.bmcl.2009.12.100
		46231709	207486	0	None	1548	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL599977	207486	0	None	1548	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)Nc4c(Cl)cccc4Cl)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		11452916	207608	0	None	7	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL600986	207608	0	None	7	3	Human	9.2	pKi	=	9.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		44268693	30121	0	None	16	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2Br)C1	10.1016/s0960-894x(00)00185-2
		CHEMBL13325	30121	0	None	16	3	Rat	9.2	pKi	=	9.2	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL	365	1	1	2	4.4	CN1CCc2cc(Cl)c(O)cc2C(c2ccccc2Br)C1	10.1016/s0960-894x(00)00185-2
		3036864	209533	19	None	-2	27	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL1256645	209533	19	None	-2	27	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL1814790	209533	19	None	-2	27	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		CHEMBL62	209533	19	None	-2	27	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrsDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2013.01.025
		46232067	207068	0	None	16	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	2	1	3	5.7	CN(C)c1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
		CHEMBL597310	207068	0	None	16	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	2	1	3	5.7	CN(C)c1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
		46232066	208035	0	None	8	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	1	3	5.7	COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
		CHEMBL603872	208035	0	None	8	4	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	1	3	5.7	COc1ccc(-c2cccc3c2CC[C@H]2[C@H]3c3cc(O)c(Cl)cc3CCN2C)cc1	10.1016/j.bmcl.2009.12.094
		46232134	208095	0	None	125	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	2	3	5.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc(CO)cc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604176	208095	0	None	125	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	419	2	2	3	5.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4ccc(CO)cc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3036864	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
		CHEMBL62	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm960318v
		3036864	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
		CHEMBL62	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm991034o
		10516818	32423	0	None	2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135197	32423	0	None	2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		14787971	176851	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccccc1[C@H]1CN(C)CCc2cc(Cl)c(O)cc21	10.1021/jm00170a025
		CHEMBL444321	176851	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccccc1[C@H]1CN(C)CCc2cc(Cl)c(O)cc21	10.1021/jm00170a025
		3036864	209533	19	None	-2	27	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
		CHEMBL1256645	209533	19	None	-2	27	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
		CHEMBL1814790	209533	19	None	-2	27	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
		CHEMBL62	209533	19	None	-2	27	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2008.05.077
		242	7258	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		34	7258	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		60795	7258	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		CHEMBL1112	7258	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		DB01238	7258	124	None	-74	51	Rat	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm100294b
		11681599	81948	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL203637	81948	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1016/j.bmcl.2008.04.081
		44439942	158644	0	None	4	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3	10.1016/j.bmcl.2006.11.093
		CHEMBL396560	158644	0	None	4	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2[nH]c3c(c2c1)CCN(C)CCc1ccccc1C3	10.1016/j.bmcl.2006.11.093
		11681599	81948	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
		CHEMBL203637	81948	0	None	-12	6	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1	10.1021/jm051237e
		10802788	175017	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL433652	175017	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		10802788	175017	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL433652	175017	0	None	-2	2	Rat	9.1	pKi	=	9.1	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	281	4	1	2	3.8	CCCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		3036864	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL1256645	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL1814790	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL62	209533	19	None	-2	27	Rat	9.1	pKi	=	9.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		46231541	206967	0	None	4	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	370	4	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL596622	206967	0	None	4	3	Human	9.1	pKi	=	9.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	370	4	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNC3CCC3)cc2)C1	10.1016/j.bmcl.2009.12.100
		107930	8311	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
		3304	8311	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
		CHEMBL298406	8311	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
		DB12273	8311	26	None	1	6	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2020.127563
		149506840	189927	0	None	120	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	371	1	1	3	5.8	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4795230	189927	0	None	120	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	371	1	1	3	5.8	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		46232065	207038	0	None	346	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	425	1	1	2	5.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cc(F)cc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL597100	207038	0	None	346	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	425	1	1	2	5.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cc(F)cc(F)c4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		46216855	207157	0	None	2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	395	1	1	3	5.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL597900	207157	0	None	2	4	Human	9.1	pKi	=	9.1	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	395	1	1	3	5.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccs4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		15111050	20120	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1192259	20120	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL543473	20120	0	None	707	2	Human	9.1	pKi	=	9.1	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	357	3	1	2	4.3	C=CCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		130844	19974	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL1191103	19974	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL543398	19974	14	None	512	2	Human	9.1	pKi	=	9.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	303	1	2	3	3.4	CN1CCc2c(cc(O)c(O)c2Cl)C(c2ccccc2)C1	10.1021/jm00116a004
		71451380	88012	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	435	3	5	6	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C(O)=C(/O)C(=O)O	10.1016/j.bmc.2012.08.058
		CHEMBL2158641	88012	0	None	-	1	Human	9.0	pKi	=	9.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	435	3	5	6	3.1	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1.O=C(O)/C(O)=C(/O)C(=O)O	10.1016/j.bmc.2012.08.058
		6852376	98374	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL1467585	98374	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL24077	98374	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL503958	98374	13	None	-3	5	Human	9.0	pKi	=	9	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		167715	9651	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		969	9651	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		CHEMBL225230	9651	14	None	-194	5	Human	9.0	pKi	=	9	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		11393666	199765	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5201983	199765	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		CHEMBL5222597	199765	0	None	-2	19	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysisDisplacement of [3H]SCH 23390 from recombinant human D1 receptor measured after 60 mins by scintillation counting analysis	ChEMBL	340	2	1	2	4.6	CC1(C)CN([C@@H]2C[C@@H](c3ccccc3)c3ccc(Cl)cc32)CCN1	10.1016/j.bmcl.2022.128879
		46231927	208315	0	None	2	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	3	1	4	5.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL605354	208315	0	None	2	4	Human	9.0	pKi	=	9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	432	3	1	4	5.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/Oc4ccccc4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		13805900	50783	0	None	-2	5	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@@H]1Cc2cccc(O)c2C[C@H]1C	10.1021/jm020990u
		CHEMBL15136	50783	0	None	-2	5	Bovine	9.0	pKi	=	9.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	261	5	1	2	3.6	CCCN(CCC)[C@@H]1Cc2cccc(O)c2C[C@H]1C	10.1021/jm020990u
		162646534	186362	0	None	123	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	362	1	1	4	5.0	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(C#N)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4742056	186362	0	None	123	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	362	1	1	4	5.0	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(C#N)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		1242	10385	27	None	-5	17	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		935	10385	27	None	-5	17	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		CHEMBL286080	10385	27	None	-5	17	Human	9.0	pKi	=	9.0	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		133538	10391	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
		8443	10391	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
		CHEMBL574558	10391	24	None	-1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2008.09.049
		107930	8311	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
		3304	8311	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
		CHEMBL298406	8311	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
		DB12273	8311	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.100
		5018	10322	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
		943	10322	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
		946	10322	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
		CHEMBL13668	10322	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	10.1016/j.bmc.2012.12.016
		107930	8311	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
		3304	8311	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
		CHEMBL298406	8311	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
		DB12273	8311	26	None	1	6	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1016/j.bmcl.2009.12.094
		15111051	20142	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1192465	20142	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL543704	20142	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	313	3	1	2	4.2	C=CCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		13697621	20513	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL1195188	20513	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL554009	20513	0	None	1148	2	Human	8.9	pKi	=	8.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	347	1	2	3	3.5	CN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		1153	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		12668023	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		30026874	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		30026875	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		3341	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		6603851	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		933	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		939	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		985	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		CHEMBL1160786	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		CHEMBL1161520	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		CHEMBL588	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		DB00800	8409	58	None	-1	10	Rat	8.9	pKi	=	8.9	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1016/0960-894X(95)00413-N
		3036864	209533	19	None	-2	27	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL1256645	209533	19	None	-2	27	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL1814790	209533	19	None	-2	27	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		CHEMBL62	209533	19	None	-2	27	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmc.2012.05.057
		5018	10322	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		943	10322	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		946	10322	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		CHEMBL13668	10322	13	None	2	10	Human	8.9	pKi	=	8.9	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	nan
		134139606	153126	0	None	288	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	419	3	2	5	3.9	CCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3921278	153126	0	None	288	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	419	3	2	5	3.9	CCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		3036864	209533	19	None	-5	27	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL1256645	209533	19	None	-5	27	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL1814790	209533	19	None	-5	27	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		CHEMBL62	209533	19	None	-5	27	Goldfish	8.9	pKi	=	8.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00114a002
		10638646	32987	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135735	32987	0	None	-	1	Rat	8.9	pKi	=	8.9	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		11486421	207973	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	400	2	2	4	4.5	CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL603485	207973	0	None	2	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	400	2	2	4	4.5	CCOC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		3036864	209533	19	None	-2	27	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL1256645	209533	19	None	-2	27	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL1814790	209533	19	None	-2	27	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL62	209533	19	None	-2	27	Human	8.9	pKi	=	8.9	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2009.12.100
		142405815	187943	0	None	-10	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	365	2	1	3	5.7	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4760903	187943	0	None	-10	3	Human	8.9	pKi	=	8.9	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	365	2	1	3	5.7	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		11223303	207609	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL600987	207609	0	None	4	3	Human	8.8	pKi	=	8.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1ccc2c(c1)CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		14787975	109009	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1	10.1021/jm00170a025
		CHEMBL303012	109009	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	301	1	1	2	4.0	Cc1ccc([C@H]2CN(C)CCc3cc(Cl)c(O)cc32)cc1	10.1021/jm00170a025
		162646218	186255	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4740880	186255	0	None	77	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		122324	6993	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
		6077	6993	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
		CHEMBL86931	6993	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00112a034
		122324	6993	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		6077	6993	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		CHEMBL86931	6993	22	None	323	3	Rat	8.8	pKi	=	8.8	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		44415569	172713	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL425069	172713	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		44415569	172713	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL425069	172713	0	None	8	6	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		46231849	208197	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	356	1	2	4	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604732	208197	0	None	2	4	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	356	1	2	4	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(/C=N/O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3036864	209533	19	None	-2	27	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
		CHEMBL1256645	209533	19	None	-2	27	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
		CHEMBL1814790	209533	19	None	-2	27	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
		CHEMBL62	209533	19	None	-2	27	Human	8.8	pKi	=	8.8	Binding	Displacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometryDisplacement of [3H]-SCH-23390 from dopamine D1 receptor (unknown origin) expressed in HEK293 cell membranes incubated for 15 mins by liquid scintillation spectrometry	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1016/j.bmcl.2015.07.030
		129244	125449	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		CHEMBL2114388	125449	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		CHEMBL34170	125449	7	None	-	1	Rat	8.8	pKi	=	8.8	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	413	1	1	2	4.3	CN1CCc2cc(Cl)c(O)cc2C(c2ccc(I)cc2)C1	10.1021/jm00127a005
		10638646	32987	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135735	32987	0	None	-	1	Rat	8.8	pKi	=	8.8	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		37461	23906	14	None	-2	8	Rat	8.7	pKi	=	8.7	Binding	Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm9911478
		CHEMBL1255588	23906	14	None	-2	8	Rat	8.7	pKi	=	8.7	Binding	Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 rat striatal receptor using [3H]SCH-23390	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/jm9911478
		46231925	208157	0	None	5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	384	3	1	4	4.4	CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		CHEMBL604525	208157	0	None	5	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	384	3	1	4	4.4	CCO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		73671785	136199	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	3	2	6	2.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3671278	136199	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	3	2	6	2.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		4350931	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL441618	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
		10656804	123337	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL336366	123337	0	None	-	1	Rat	8.7	pKi	=	8.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		107930	8311	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
		3304	8311	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
		CHEMBL298406	8311	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
		DB12273	8311	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00170a025
		107930	8311	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		3304	8311	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		CHEMBL298406	8311	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		DB12273	8311	26	None	1	6	Human	8.7	pKi	=	8.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		4350931	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
		CHEMBL441618	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm051237e
		4350931	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
		CHEMBL441618	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
		4350931	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL441618	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
		4350931	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1039/C5MD00258C
		CHEMBL441618	176092	44	None	-63	7	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1039/C5MD00258C
		12765746	109057	4	None	-18	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL303313	109057	4	None	-18	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		12765746	109057	4	None	-18	9	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL303313	109057	4	None	-18	9	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		9797664	173016	1	None	-4	2	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	331	1	0	4	3.8	CN1CCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL426763	173016	1	None	-4	2	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	331	1	0	4	3.8	CN1CCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		107930	8311	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
		3304	8311	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
		CHEMBL298406	8311	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
		DB12273	8311	26	None	-1	6	Rat	8.7	pKi	=	8.7	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	10.1021/jm00128a038
		133538	10391	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
		8443	10391	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
		CHEMBL574558	10391	24	None	-1	6	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	10.1016/j.bmc.2009.06.019
		12765746	109057	4	None	-18	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL303313	109057	4	None	-18	9	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		4106	9280	22	None	-5	33	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
		5358812	9280	22	None	-5	33	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
		89	9280	22	None	-5	33	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
		CHEMBL93240	9280	22	None	-5	33	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	10.1021/jm010982y
		44348383	23075	0	None	-10	2	Rat	8.7	pKi	=	8.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1021/jm9706832
		CHEMBL122536	23075	0	None	-10	2	Rat	8.7	pKi	=	8.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	205	3	1	2	2.7	CSc1ccc2c(c1)C(CCN)=CC2	10.1021/jm9706832
		135398745	9688	112	None	-26	65	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		47	9688	112	None	-26	65	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		CHEMBL715	9688	112	None	-26	65	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		DB00334	9688	112	None	-26	65	Human	8.0	pKi	=	8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0002432
		15937726	171928	0	None	177	2	Rat	8.0	pKi	=	8	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	293	1	1	2	4.2	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL422796	171928	0	None	177	2	Rat	8.0	pKi	=	8	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	293	1	1	2	4.2	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		44579030	196460	0	None	10	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	377	7	0	3	5.7	CCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		CHEMBL515342	196460	0	None	10	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	377	7	0	3	5.7	CCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		44415558	86937	0	None	93	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4n3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213443	86937	0	None	93	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4n3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415657	175520	0	None	17	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	4	1	7	4.9	CCOc1csc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		CHEMBL437112	175520	0	None	17	2	Human	8.0	pKi	=	8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	4	1	7	4.9	CCOc1csc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		117773683	139220	0	None	-	1	Human	8.0	pKi	=	8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	403	5	1	6	3.5	Cc1cc(Oc2nccc(C)c2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697583	139220	0	None	-	1	Human	8.0	pKi	=	8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	403	5	1	6	3.5	Cc1cc(Oc2nccc(C)c2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		56594534	77375	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO	10.1021/jm200676f
		CHEMBL1949728	77375	0	None	1	5	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@@H]1CO	10.1021/jm200676f
		90140327	136190	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]c(C)c23)cc1	nan
		CHEMBL3671269	136190	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]c(C)c23)cc1	nan
		74223724	136195	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3671274	136195	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		74223826	136215	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3671293	136215	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
		11637457	79862	1	None	1	5	Human	8.0	pKi	=	8.0	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
		CHEMBL201093	79862	1	None	1	5	Human	8.0	pKi	=	8.0	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1021/jm050846j
		86764102	139256	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1ccnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)cc2)c1Cl	nan
		CHEMBL3697619	139256	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1ccnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)cc2)c1Cl	nan
		135398745	9688	112	None	-26	65	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		47	9688	112	None	-26	65	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		CHEMBL715	9688	112	None	-26	65	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		DB00334	9688	112	None	-26	65	Human	7.0	pKi	=	7	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C2MD00311B
		11271099	211436	0	None	-501	4	Rat	7.0	pKi	=	7	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	458	9	2	5	4.3	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(N)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		CHEMBL73665	211436	0	None	-501	4	Rat	7.0	pKi	=	7	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	458	9	2	5	4.3	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(N)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		15937722	122002	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	294	1	1	3	3.1	CN1CCc2cc(Cl)c(O)cc2C(N2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL334650	122002	0	None	-	1	Rat	7.0	pKi	=	7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	294	1	1	3	3.1	CN1CCc2cc(Cl)c(O)cc2C(N2CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		49782398	24224	0	None	-138	5	Pig	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	471	6	1	3	5.7	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
		CHEMBL1257688	24224	0	None	-138	5	Pig	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	471	6	1	3	5.7	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
		6603820	102549	19	None	1	12	Rat	7.0	pKi	=	7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL25856	102549	19	None	1	12	Rat	7.0	pKi	=	7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm970038v
		15711850	20011	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL1191350	20011	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL542436	20011	0	None	-1	5	Goldfish	7.0	pKi	=	7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		242	7258	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		34	7258	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		60795	7258	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		CHEMBL1112	7258	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		DB01238	7258	124	None	-281	51	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1039/C2MD00311B
		135398737	7745	93	None	-44	90	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		38	7745	93	None	-44	90	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		722	7745	93	None	-44	90	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		CHEMBL42	7745	93	None	-44	90	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		DB00363	7745	93	None	-44	90	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C2MD00311B
		2337	10030	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		50	10030	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		5002	10030	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		CHEMBL716	10030	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		DB01224	10030	77	None	-53	62	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1039/C2MD00311B
		2389	10104	118	None	-489	66	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		5073	10104	118	None	-489	66	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		96	10104	118	None	-489	66	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		CHEMBL85	10104	118	None	-489	66	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		DB00734	10104	118	None	-489	66	Human	6.0	pKi	=	6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1039/C2MD00311B
		17449900	146320	13	None	-3548	6	Pig	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL379602	146320	13	None	-3548	6	Pig	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	348	5	0	5	3.2	COc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
		137633863	163404	0	None	-436	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4069145	163404	0	None	-436	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(/C=N/O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		44372154	60999	0	None	-11	4	Bovine	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	434	4	0	4	5.4	Cc1nn2c(-c3ccc(F)cc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		CHEMBL160749	60999	0	None	-11	4	Bovine	6.0	pKi	=	6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	434	4	0	4	5.4	Cc1nn2c(-c3ccc(F)cc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		9864676	134586	0	None	-58	5	Bovine	6.0	pKi	=	6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL366388	134586	0	None	-58	5	Bovine	6.0	pKi	=	6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	380	6	0	3	4.5	O=C(CCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		15115530	19690	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
		CHEMBL1189085	19690	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
		CHEMBL538023	19690	0	None	-	1	Human	5.0	pKi	=	5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	659	3	7	9	6.4	O=C1OC2(c3ccc(O)cc3Oc3cc(O)ccc32)c2ccc(N/C(S)=N\c3ccc(C4CNCCc5cc(O)c(O)cc54)cc3)cc21	10.1021/jm00115a012
		44339879	179061	0	None	-186	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL447476	179061	0	None	-186	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
		10357869	11656	0	None	-158	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3cccc3-c3cnco3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		CHEMBL104453	11656	0	None	-158	4	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3cccc3-c3cnco3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		44412458	146072	3	None	-3090	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	316	4	0	4	3.6	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)nn2)C1	10.1016/j.bmcl.2006.02.075
		CHEMBL379177	146072	3	None	-3090	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	316	4	0	4	3.6	C1=C(c2ccccc2)CCN(Cc2cn(-c3ccccc3)nn2)C1	10.1016/j.bmcl.2006.02.075
		45112568	205585	0	None	-229	3	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
		CHEMBL583422	205585	0	None	-229	3	Rat	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
		145980271	173271	0	None	-19	16	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4278465	173271	0	None	-19	16	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	538	8	1	3	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		145986752	174055	0	None	-23	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		CHEMBL4293307	174055	0	None	-23	17	Human	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	562	10	1	5	7.3	COc1ccc(N(CCCCN2CCC(O)(c3ccc(Cl)c(C(F)(F)F)c3)CC2)c2ccc(OC)cc2)cc1	10.1016/j.bmcl.2018.10.036
		10633305	42768	1	None	-28	2	Bovine	4.0	pKi	=	4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2ccc(C)cc2C)C1	10.1021/jm9708700
		CHEMBL144302	42768	1	None	-28	2	Bovine	4.0	pKi	=	4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2ccc(C)cc2C)C1	10.1021/jm9708700
		44329093	214491	0	None	-309	3	Bovine	4.0	pKi	=	4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@@H]1CCn2ccc(CO)c2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL95618	214491	0	None	-309	3	Bovine	4.0	pKi	=	4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@@H]1CCn2ccc(CO)c2C1	10.1016/s0960-894x(01)00564-9
		44304814	209651	0	None	-16	4	Bovine	4.0	pKi	=	4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	505	8	1	5	5.9	COc1c(-c2nc(CNC[C@@H]3CCN(Cc4ccccc4)C3)co2)cc(Br)c2ccccc12	10.1016/s0960-894x(00)00405-4
		CHEMBL62601	209651	0	None	-16	4	Bovine	4.0	pKi	=	4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	505	8	1	5	5.9	COc1c(-c2nc(CNC[C@@H]3CCN(Cc4ccccc4)C3)co2)cc(Br)c2ccccc12	10.1016/s0960-894x(00)00405-4
		71109993	150025	0	None	-	1	Human	6.0	pKi	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
		CHEMBL3896617	150025	0	None	-	1	Human	6.0	pKi	=	6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1ccc2c(c1)CCN1Cc3c(cc(OC)c(OC)c3OC)CC21	nan
		228	7233	28	None	-4	23	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		33	7233	28	None	-4	23	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		6005	7233	28	None	-4	23	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		CHEMBL53	7233	28	None	-4	23	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		DB00714	7233	28	None	-4	23	Mouse	7.0	pKi	=	7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.02.038
		228	7233	28	None	-30	23	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		33	7233	28	None	-30	23	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		6005	7233	28	None	-30	23	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		CHEMBL53	7233	28	None	-30	23	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		DB00714	7233	28	None	-30	23	Rat	6.0	pKi	=	6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		74223776	136210	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1C#N	nan
		CHEMBL3671289	136210	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1C#N	nan
		28417	46813	49	None	-1	12	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		CHEMBL1479	46813	49	None	-1	12	Human	5.0	pKi	=	5.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	nan
		15711865	19947	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		CHEMBL1190906	19947	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		CHEMBL541838	19947	0	None	-1	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		3246545	209253	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL1573438	209253	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL611207	209253	1	None	-7	5	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		44415394	148611	0	None	15	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	471	3	1	5	4.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)/C=C/c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL386424	148611	0	None	15	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	471	3	1	5	4.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)/C=C/c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		13864380	213211	1	None	4	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL87958	213211	1	None	4	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	195	1	3	4	0.7	NC[C@@H]1OCCc2c1ccc(O)c2O	10.1021/jm00112a034
		13864381	215123	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
		CHEMBL542683	215123	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
		CHEMBL99361	215123	3	None	4	4	Rat	6.0	pKi	=	6.0	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	195	1	3	4	0.7	NCC1OCCc2c1ccc(O)c2O	10.1021/jm00173a005
		10637496	119661	0	None	-58	3	Rat	6.0	pKi	=	6.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	2	0	2	4.0	CCc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL331005	119661	0	None	-58	3	Rat	6.0	pKi	=	6.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	2	0	2	4.0	CCc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		44405995	79771	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
		CHEMBL200802	79771	0	None	-1	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
		56593482	10713	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		7650	10713	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL2165119	10713	3	None	-954	9	Human	6.0	pKi	=	6.0	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	462	7	1	5	4.6	O=C1CCc2c(N1)nc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		156018236	184691	0	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	377	4	1	3	4.9	C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4645139	184691	0	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	377	4	1	3	4.9	C=CCN1CCc2cc(OC)c(O)cc2C(c2c(Cl)cccc2Cl)C1	10.1016/j.bmcl.2020.127305
		154706030	183324	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4580817	183324	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4597188	183324	1	None	-50	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		76325156	113167	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		CHEMBL3115585	113167	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		CHEMBL3139393	113167	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		12050197	107651	0	None	-79	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	457	6	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL293645	107651	0	None	-79	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	457	6	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		10570422	171684	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	6	2	3	4.0	CNCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL422267	171684	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	6	2	3	4.0	CNCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		15627832	105310	0	None	-6	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	345	0	2	3	3.6	CN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL276326	105310	0	None	-6	3	Rat	7.0	pKi	=	7.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	345	0	2	3	3.6	CN1CCc2cc(Br)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		13646434	131432	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL1743799	131432	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL36416	131432	0	None	-	1	Rat	7.0	pKi	=	7.0	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		70692652	82839	0	None	8	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057441	82839	0	None	8	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		72708059	98971	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425369	98971	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		161665	179364	35	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		CHEMBL448891	179364	35	None	1	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		1353	8692	93	None	-38	85	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		3559	8692	93	None	-38	85	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		86	8692	93	None	-38	85	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		CHEMBL54	8692	93	None	-38	85	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		DB00502	8692	93	None	-38	85	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm1013693
		72708059	98971	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425369	98971	0	None	1	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	301	0	2	3	3.4	Oc1ccc2c(c1)CC1c3cc(O)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		45112462	203745	0	None	-831	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
		CHEMBL566533	203745	0	None	-831	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 in rat striatum by liquid scintillation counting	ChEMBL	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	10.1016/j.ejmech.2009.11.023
		154706123	183067	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4593394	183067	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595145	183067	1	None	-134	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		11724078	48481	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cccnc3Oc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		CHEMBL149240	48481	1	None	-2	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cccnc3Oc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		154706513	183365	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		CHEMBL4440698	183365	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		CHEMBL4597532	183365	1	None	-16	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	480	12	0	6	5.6	COc1ccc(F)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		3117	214620	103	None	-2	16	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		CHEMBL964	214620	103	None	-2	16	Human	6.0	pKi	=	6.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	nan
		44448066	101650	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		CHEMBL253948	101650	0	None	-1	2	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		154704141	183458	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4561808	183458	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4598299	183458	1	None	-46	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	3	5.0	CCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		117774721	139223	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	5	1	6	2.8	Cc1c(-c2ccc(Oc3ncccc3OC(F)F)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697586	139223	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	5	1	6	2.8	Cc1c(-c2ccc(Oc3ncccc3OC(F)F)cc2)n(C)c(=O)[nH]c1=O	nan
		112500032	139248	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697610	139248	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)cnc(=O)n1C	nan
		10333842	105207	1	None	-50	8	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
		CHEMBL27559	105207	1	None	-50	8	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
		76325156	113167	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		CHEMBL3115585	113167	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		CHEMBL3139393	113167	1	None	-15135	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	263	7	2	3	3.3	CCCCCCNC[C@H]1CCc2ccc(O)cc2O1	10.1021/jm401384w
		9951964	213137	0	None	-22	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm00042a009
		CHEMBL87458	213137	0	None	-22	4	Rat	6.0	pKi	=	6.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	383	5	0	3	4.3	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3cc(F)ccc3C2=O)CC1	10.1021/jm00042a009
		44415644	148599	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	583	4	1	5	7.3	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4N(NC(=O)c4ccccc4Cl)c4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL386336	148599	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	583	4	1	5	7.3	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4N(NC(=O)c4ccccc4Cl)c4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
		10490043	120498	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960189i
		CHEMBL332332	120498	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960189i
		44386623	67829	0	None	-1	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	376	3	0	4	4.2	COc1c(Cl)c2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
		CHEMBL176356	67829	0	None	-1	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	376	3	0	4	4.2	COc1c(Cl)c2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
		1212	8443	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		204	8443	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		3372	8443	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		CHEMBL726	8443	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		DB00623	8443	50	None	-51	65	Human	8.0	pKi	=	8.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	nan
		44415633	86782	0	None	8	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	7	5.1	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL212807	86782	0	None	8	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	7	5.1	COc1cccc(OC)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		44415578	148281	0	None	57	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL384500	148281	0	None	57	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		134151737	159753	0	None	12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	5	2	5	3.9	CCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3975220	159753	0	None	12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	5	2	5	3.9	CCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		127031424	145647	0	None	5	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	6	1	5	4.2	CCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3781840	145647	0	None	5	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	6	1	5	4.2	CCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		75201901	173204	19	None	-1	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4277264	173204	19	None	-1	24	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		44370173	55259	1	None	-18	2	Bovine	7.0	pKi	=	7.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	331	6	2	4	4.0	CCCN(CCc1cccs1)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
		CHEMBL155613	55259	1	None	-18	2	Bovine	7.0	pKi	=	7.0	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	331	6	2	4	4.0	CCCN(CCc1cccs1)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
		75201901	173204	19	None	-1	24	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4277264	173204	19	None	-1	24	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.9b00351
		122189393	130026	0	None	-20	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	455	6	0	7	4.0	Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		CHEMBL3613879	130026	0	None	-20	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	455	6	0	7	4.0	Clc1cccc(N2CCN(CCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		122189394	130027	0	None	-354	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	7	0	7	4.4	Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		CHEMBL3613880	130027	0	None	-354	5	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	7	0	7	4.4	Clc1cccc(N2CCN(CCCCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		21302486	116577	0	None	-117	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	379	5	1	4	3.9	O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCN3)c1ccc(F)cc1	10.1021/jm401958n
		CHEMBL3233143	116577	0	None	-117	4	Human	7.0	pKi	=	7.0	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	379	5	1	4	3.9	O=C(CCCN1CC[C@H]2[C@@H](C1)c1cccc3c1N2CCN3)c1ccc(F)cc1	10.1021/jm401958n
		10092819	23545	0	None	-1412	11	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
		CHEMBL124444	23545	0	None	-1412	11	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm025558r
		11133602	37548	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		CHEMBL139600	37548	0	None	-63	5	Human	6.0	pKi	=	6.0	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		44276404	105854	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL28054	105854	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cnccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		44276557	106092	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL282136	106092	0	None	-2	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cncc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		11761412	123729	0	None	-2290	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	411	9	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.09.142
		CHEMBL338606	123729	0	None	-2290	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	411	9	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)/C=C/c2ccc(F)cc2)CC1	10.1016/j.bmcl.2010.09.142
		10490043	120498	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm060959i
		CHEMBL332332	120498	0	None	-190	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	237	0	2	2	2.8	Oc1cccc2c1-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm060959i
		71459761	90855	0	None	-181	7	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	540	7	0	5	6.1	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207642	90855	0	None	-181	7	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	540	7	0	5	6.1	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccc(Cl)cc4)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		137635685	162784	0	None	-38	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	417	7	1	7	3.6	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12	10.1021/acs.jmedchem.7b00363
		CHEMBL4061986	162784	0	None	-38	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	417	7	1	7	3.6	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2cccnc12	10.1021/acs.jmedchem.7b00363
		25072633	166000	0	None	-1584	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4098803	166000	0	None	-1584	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccc3ccnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		118709166	120189	0	None	-19	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	25	0	8	12.9	O=C(CCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318838	120189	0	None	-19	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	25	0	8	12.9	O=C(CCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		164615845	191969	0	None	-1	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
		CHEMBL4857492	191969	0	None	-1	6	Human	6.0	pKi	=	6.0	Binding	Inhibition of dopamine D1 receptor (unknown origin)Inhibition of dopamine D1 receptor (unknown origin)	ChEMBL	389	2	1	4	3.7	O=C(O)c1ccc(C#Cc2ccc3c(c2)C=C([N+](=O)[O-])C(C(F)(F)F)O3)cc1	10.1016/j.bmcl.2021.128008
		10833953	37898	0	None	-1445	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cc2c1	10.1021/jm0009989
		CHEMBL140006	37898	0	None	-1445	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cc2c1	10.1021/jm0009989
		44380697	64867	0	None	-61	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL167414	64867	0	None	-61	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		44380685	65509	0	None	-77	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL168566	65509	0	None	-77	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	373	6	2	4	3.2	COc1cc(N)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		44380815	65784	0	None	-234	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL169193	65784	0	None	-234	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		44264682	104093	0	None	-2754	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)c1	10.1016/s0960-894x(98)00692-1
		CHEMBL269202	104093	0	None	-2754	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)c1	10.1016/s0960-894x(98)00692-1
		15508243	12075	22	None	-7	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	366	3	0	2	3.9	Ic1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL106635	12075	22	None	-7	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	366	3	0	2	3.9	Ic1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		25099153	194032	0	None	-4073	2	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	436	9	2	5	4.7	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL492664	194032	0	None	-4073	2	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	436	9	2	5	4.7	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		45270021	201943	0	None	-158	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	335	3	0	5	3.0	Cc1cc2nc(C)c(CN3CCN(c4ccccc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL550392	201943	0	None	-158	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	335	3	0	5	3.0	Cc1cc2nc(C)c(CN3CCN(c4ccccc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		45272580	203235	0	None	-165	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cnc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL563109	203235	0	None	-165	4	Bovine	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cnc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
		102262219	146837	0	None	-22908	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800400	146837	0	None	-22908	6	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		137655029	165725	0	None	-2691	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	452	8	1	9	2.6	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12	10.1016/j.bmc.2017.08.037
		CHEMBL4095881	165725	0	None	-2691	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	452	8	1	9	2.6	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc12	10.1016/j.bmc.2017.08.037
		137657427	166338	0	None	-9772	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	476	7	3	6	3.5	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4102628	166338	0	None	-9772	5	Human	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	476	7	3	6	3.5	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		10361512	61213	0	None	-4786	5	Bovine	5.0	pKi	=	5.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	365	3	0	5	3.5	Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		CHEMBL160932	61213	0	None	-4786	5	Bovine	5.0	pKi	=	5.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	365	3	0	5	3.5	Cc1nn2c(C#N)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		154706590	183088	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4590839	183088	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595264	183088	1	None	-58	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		71110301	98973	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425371	98973	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		44415368	86378	0	None	17	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	465	4	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCC3CCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL211461	86378	0	None	17	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	465	4	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCC3CCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		14198586	208612	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL60706	208612	0	None	2	2	Rat	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1016/j.bmc.2009.05.079
		156013666	184058	0	None	-10	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	3	1	4	3.6	COc1cc2c3c(c1OC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4636318	184058	0	None	-10	3	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	3	1	4	3.6	COc1cc2c3c(c1OC1CC1)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		2726	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		621	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		83	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		CHEMBL71	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		DB00477	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	nan
		154704536	183226	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4467528	183226	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4596340	183226	1	None	-2	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCOc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		154703875	183227	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4586582	183227	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4596341	183227	1	None	-87	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		11335419	73874	1	None	-11	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/jm049720x
		CHEMBL187367	73874	1	None	-11	6	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	7	0	2	4.1	c1ccc(Cc2ccccc2OCCCN2CCCC2)cc1	10.1021/jm049720x
		74223726	136197	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	10.1021/acs.jmedchem.8b01767
		CHEMBL3671276	136197	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	10.1021/acs.jmedchem.8b01767
		74223726	136197	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
		CHEMBL3671276	136197	16	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	331	3	1	5	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
		10497993	175253	0	None	2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL43514	175253	0	None	2	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	349	1	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3cc(-c4ccccc4)sc3CN[C@H]1CC2	10.1021/jm970038v
		3038495	7495	37	None	-616	18	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
		7625	7495	37	None	-616	18	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
		CHEMBL25236	7495	37	None	-616	18	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/acs.jmedchem.9b01835
		136074293	209836	0	None	-3	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1cnc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm00067a009
		CHEMBL63590	209836	0	None	-3	2	Rat	6.0	pKi	=	6.0	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1cnc2c(c1)N=C(N1CCN(C)CC1)c1ccccc1N2	10.1021/jm00067a009
		45481842	204840	0	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	3	1	2	3.8	CCCCC1c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
		CHEMBL574112	204840	0	None	-2	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	3	1	2	3.8	CCCCC1c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
		56589561	77376	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO	10.1021/jm200676f
		CHEMBL1949729	77376	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	320	1	2	2	3.2	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2C[C@H]1CO	10.1021/jm200676f
		135398737	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		38	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		722	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		CHEMBL42	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		DB00363	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00030a011
		242	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		34	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		60795	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL1112	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		DB01238	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		242	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		34	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		60795	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL1112	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		DB01238	7258	124	None	-281	51	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		76325154	113183	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		CHEMBL3115580	113183	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		CHEMBL3139475	113183	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		154703647	183144	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4450429	183144	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4595728	183144	1	None	-20	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCOc1ccc(F)cc1C1CC1CN(CC)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		135398737	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		38	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		722	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		CHEMBL42	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		DB00363	7745	93	None	-83	90	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00067a009
		156016177	184433	0	None	-114	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
		CHEMBL4641502	184433	0	None	-114	7	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	307	0	1	4	3.6	CN1CCc2cccc3c2C1Cc1ccc2nc(N)sc2c1-3	10.1016/j.bmc.2020.115578
		12049520	107842	5	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	319	4	0	4	3.7	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)co2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL294780	107842	5	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	319	4	0	4	3.7	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)co2)cc1	10.1016/s0960-894x(00)00405-4
		44593524	190835	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2008.05.077
		CHEMBL482276	190835	0	None	1	4	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmc.2008.05.077
		76325154	113183	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		CHEMBL3115580	113183	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		CHEMBL3139475	113183	0	None	-35	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1OCCCCF)CC2	10.1021/jm401384w
		44448062	101623	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL253737	101623	0	None	1	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		117774133	139196	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	5	4.1	Cc1cc(Oc2ncc(Cl)cc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697559	139196	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	5	4.1	Cc1cc(Oc2ncc(Cl)cc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		90644065	118438	0	None	-8	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	5	0	4	4.2	Clc1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3286429	118438	0	None	-8	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	5	0	4	4.2	Clc1ccc(N2CCN(CCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		53318565	65375	0	None	-6	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684134	65375	0	None	-6	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		10000788	54767	0	None	-41	3	Rat	5.9	pKi	=	5.9	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	395	6	1	4	3.9	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCN(c3ccccc3OC)CC1)CC2	10.1016/0960-894X(95)00076-6
		CHEMBL155006	54767	0	None	-41	3	Rat	5.9	pKi	=	5.9	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	395	6	1	4	3.9	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCN(c3ccccc3OC)CC1)CC2	10.1016/0960-894X(95)00076-6
		10832461	58038	0	None	-1	2	Rat	4.9	pKi	=	4.9	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)c2c(c1)CCN(C)C2Cc1ccccc1O	10.1021/jm991034o
		CHEMBL158067	58038	0	None	-1	2	Rat	4.9	pKi	=	4.9	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)c2c(c1)CCN(C)C2Cc1ccccc1O	10.1021/jm991034o
		86763998	139252	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697614	139252	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		135398745	9688	112	None	-23	65	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		47	9688	112	None	-23	65	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		CHEMBL715	9688	112	None	-23	65	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		DB00334	9688	112	None	-23	65	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049632c
		91899760	136225	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	1	5	4.3	Cc1cc(Oc2nccc3n[nH]cc23)c(F)cc1-c1c(C)ncnc1C	nan
		CHEMBL3671302	136225	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	1	5	4.3	Cc1cc(Oc2nccc3n[nH]cc23)c(F)cc1-c1c(C)ncnc1C	nan
		12304090	94283	36	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@H]21	10.1016/j.bmc.2012.12.016
		CHEMBL2334886	94283	36	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@H]21	10.1016/j.bmc.2012.12.016
		135398745	9688	112	None	-26	65	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		47	9688	112	None	-26	65	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		CHEMBL715	9688	112	None	-26	65	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		DB00334	9688	112	None	-26	65	Human	6.9	pKi	=	6.9	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/S0960-894X(96)00567-7
		168289523	198278	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysisDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis	ChEMBL	422	5	1	2	6.0	FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1	10.1016/j.bmcl.2022.128615
		CHEMBL5193761	198278	0	None	-5	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysisDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cell membrane by competitive inhibition based analysis	ChEMBL	422	5	1	2	6.0	FC(F)(F)c1cccc(COC2CCN(Cc3cc4ccc(Cl)cc4[nH]3)CC2)c1	10.1016/j.bmcl.2022.128615
		10276451	207064	37	None	-3388	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		CHEMBL2112910	207064	37	None	-3388	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		CHEMBL59725	207064	37	None	-3388	9	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		10531	8202	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		121	8202	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		888	8202	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL1732	8202	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00320	8202	21	None	-218	24	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		2435	10362	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		60149	10362	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		98	10362	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		CHEMBL12713	10362	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		DB06144	10362	83	None	-43	48	Rat	7.9	pKi	=	7.9	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm020938y
		25141414	189260	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	5	0	3	4.9	CCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		CHEMBL478671	189260	0	None	-1	4	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	5	0	3	4.9	CCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		44415721	86817	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	605	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212936	86817	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	605	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415703	86596	0	None	537	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)c(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212077	86596	0	None	537	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)c(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415688	86946	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213477	86946	0	None	30	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		134143833	157294	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	355	4	2	5	3.6	CCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3954556	157294	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	355	4	2	5	3.6	CCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		127031403	145512	0	None	4	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	381	5	1	5	3.9	COc1cc2c(cc1O)C1Cc3ccc(OCC4CC4)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		CHEMBL3780184	145512	0	None	4	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	381	5	1	5	3.9	COc1cc2c(cc1O)C1Cc3ccc(OCC4CC4)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		10733562	153792	0	None	25	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL39266	153792	0	None	25	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3cc(Cl)sc3CN[C@H]1CC2	10.1021/jm970038v
		9819042	19929	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
		CHEMBL1190761	19929	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
		CHEMBL541559	19929	3	None	23	2	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	333	1	3	3	3.1	Oc1cc2c(c(Br)c1O)CCNCC2c1ccccc1	10.1021/jm00116a004
		1241	106955	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL288090	106955	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL552611	106955	24	None	-2	8	Human	7.9	pKi	=	7.9	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00116a004
		117773867	139232	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	1	4	4.9	Cc1cc(Oc2nccc(C)c2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697594	139232	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	1	4	4.9	Cc1cc(Oc2nccc(C)c2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		6917970	10463	61	None	-1	33	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
		8370	10463	61	None	-1	33	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
		CHEMBL487387	10463	61	None	-1	33	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2014.09.024
		127031422	145496	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	4	1	5	3.5	CCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3779928	145496	0	None	3	3	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	355	4	1	5	3.5	CCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		14198584	205048	0	None	12	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00118a012
		CHEMBL57579	205048	0	None	12	2	Rat	7.9	pKi	=	7.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00118a012
		117773559	139261	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	416	3	2	5	3.7	Cc1c(-c2ccc(Oc3ncccc3C(F)(F)F)c3[nH]ccc23)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697624	139261	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	416	3	2	5	3.7	Cc1c(-c2ccc(Oc3ncccc3C(F)(F)F)c3[nH]ccc23)n(C)c(=O)[nH]c1=O	nan
		10005244	118128	0	None	7	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	476	5	1	3	5.9	CN(C)c1ccc(/C=C/CN2CCc3cc(Br)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		CHEMBL326927	118128	0	None	7	2	Rat	6.9	pKi	=	6.9	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	476	5	1	3	5.9	CN(C)c1ccc(/C=C/CN2CCc3cc(Br)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		44323876	213361	0	None	2	4	Rat	6.9	pKi	=	6.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL88870	213361	0	None	2	4	Rat	6.9	pKi	=	6.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	330	1	0	2	4.6	CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		1353	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		3559	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		86	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		CHEMBL54	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		DB00502	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2008.06.030
		117773696	139204	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	6	2.7	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1F	nan
		CHEMBL3697567	139204	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	6	2.7	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1F	nan
		86764101	139255	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
		CHEMBL3697618	139255	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
		276	10286	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		5312149	10286	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		CHEMBL431298	10286	50	None	-81	13	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	451	5	2	6	4.1	COc1ccc(cc1N1CCNCC1)NS(=O)(=O)c1sc2c(c1C)cc(cc2)Cl	10.1016/j.bmcl.2007.11.045
		11575479	101518	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		CHEMBL253096	101518	0	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	425	4	1	3	5.7	CC1(c2cccc(OCc3ccccc3)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		1353	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		3559	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		86	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		CHEMBL54	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		DB00502	8692	93	None	-38	85	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.07.018
		118709178	120125	0	None	-69	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1154	32	0	17	9.5	O=C(CCc1cn(CCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3317465	120125	0	None	-69	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1154	32	0	17	9.5	O=C(CCc1cn(CCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		122189392	130025	0	None	-54	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	441	5	0	7	3.6	Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		CHEMBL3613878	130025	0	None	-54	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	441	5	0	7	3.6	Clc1cccc(N2CCN(CCc3cn(-c4ccn5nccc5c4)nn3)CC2)c1Cl	10.1016/j.bmc.2015.07.050
		71458071	86275	0	None	-102	6	Bovine	5.9	pKi	=	5.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(02)00316-5
		CHEMBL2113718	86275	0	None	-102	6	Bovine	5.9	pKi	=	5.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(02)00316-5
		6603820	102549	19	None	-4	12	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9800292
		CHEMBL25856	102549	19	None	-4	12	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm9800292
		6603954	209384	2	None	-81	3	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm9800292
		CHEMBL612083	209384	2	None	-81	3	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm9800292
		11068912	37637	0	None	-39	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		CHEMBL139722	37637	0	None	-39	4	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		11057969	40045	0	None	-1778	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		CHEMBL141845	40045	0	None	-1778	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	379	6	1	6	1.9	COc1ccccc1N1CCN(CCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		44360992	126182	0	None	-134	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1	10.1021/jm025558r
		CHEMBL344677	126182	0	None	-134	6	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc3ccnn23)CC1	10.1021/jm025558r
		11036640	127925	0	None	-29	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		CHEMBL357684	127925	0	None	-29	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		44264642	211582	0	None	-398	4	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
		CHEMBL7506	211582	0	None	-398	4	Bovine	5.9	pKi	=	5.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
		56833463	75111	0	None	-602	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	578	17	1	9	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
		CHEMBL1916552	75111	0	None	-602	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	578	17	1	9	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
		137643951	165038	0	None	-831	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	8	1	7	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4088639	165038	0	None	-831	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	8	1	7	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		56837635	76083	0	None	-3981	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1129	44	2	17	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928132	76083	0	None	-3981	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1129	44	2	17	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		118709164	120187	0	None	-199	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	902	22	0	8	11.7	O=C(CCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318836	120187	0	None	-199	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	902	22	0	8	11.7	O=C(CCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		44371932	126426	0	None	-467	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	354	4	0	5	3.1	O=Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL346805	126426	0	None	-467	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	354	4	0	5	3.1	O=Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		10404144	212081	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(02)00316-5
		CHEMBL7927	212081	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(02)00316-5
		10404144	212081	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm015522j
		CHEMBL7927	212081	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm015522j
		44380785	127581	0	None	-363	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL355566	127581	0	None	-363	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		10404144	212081	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL7927	212081	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		10404144	212081	23	None	-2187	10	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm060166w
		CHEMBL7927	212081	23	None	-2187	10	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm060166w
		44340097	16212	0	None	-4365	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL111749	16212	0	None	-4365	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		45270861	201859	0	None	-33	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	353	3	0	5	3.1	Cc1cc2nc(C)c(CN3CCN(c4ccc(F)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL549638	201859	0	None	-33	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	353	3	0	5	3.1	Cc1cc2nc(C)c(CN3CCN(c4ccc(F)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		681	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		940	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		947	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		CHEMBL59	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		DB00988	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.ejmech.2012.07.025
		137651322	164254	0	None	-13489	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	465	8	2	9	2.2	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12	10.1016/j.bmc.2017.08.037
		CHEMBL4079375	164254	0	None	-13489	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	465	8	2	9	2.2	O=Cc1cnn2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc12	10.1016/j.bmc.2017.08.037
		137640189	163732	0	None	-15848	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	466	7	3	7	2.6	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4072780	163732	0	None	-15848	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	466	7	3	7	2.6	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		681	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		940	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		947	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		CHEMBL59	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		DB00988	8247	72	None	-154	38	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.05.014
		107995	103901	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
		29982233	103901	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
		CHEMBL267723	103901	20	None	-28840	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	404	5	2	4	2.2	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(I)c1O	10.1016/j.bmc.2007.07.017
		44329282	175894	0	None	-19	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL440143	175894	0	None	-19	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
		10404144	212081	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		CHEMBL7927	212081	23	None	-4466	10	Bovine	4.9	pKi	=	4.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		10247720	19826	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL1190042	19826	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL540039	19826	1	None	-794	5	Bovine	4.9	pKi	=	4.9	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	320	4	1	4	2.2	c1ccc(C2=NC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(01)00484-x
		10474964	137249	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL368061	137249	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL5206021	137249	0	None	-8511	7	Bovine	4.9	pKi	=	4.9	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		10404144	212081	23	None	-4466	10	Human	4.9	pKi	=	4.9	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/acs.jmedchem.7b00151
		CHEMBL7927	212081	23	None	-4466	10	Human	4.9	pKi	=	4.9	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/acs.jmedchem.7b00151
		45481841	204839	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(Cl)c(O)cc21	10.1016/j.bmc.2009.05.079
		CHEMBL574111	204839	0	None	-14	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(Cl)c(O)cc21	10.1016/j.bmc.2009.05.079
		90142280	174075	1	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
		CHEMBL4293757	174075	1	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	361	3	0	5	5.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)cnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
		15711855	20184	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL1192799	20184	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL544099	20184	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		13838742	106177	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
		CHEMBL282710	106177	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
		117773223	139229	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	350	4	2	5	2.6	Cc1cc(Oc2ncccc2C(N)=O)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697591	139229	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	350	4	2	5	2.6	Cc1cc(Oc2ncccc2C(N)=O)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		25129807	110071	0	None	-63	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	366	3	2	2	4.8	O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
		CHEMBL3084502	110071	0	None	-63	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	366	3	2	2	4.8	O[C@@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
		91899762	136230	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cn[nH]c(=O)c1C	nan
		CHEMBL3671307	136230	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cn[nH]c(=O)c1C	nan
		491	6980	9	None	-151356	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		9891167	6980	9	None	-151356	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		CHEMBL13856	6980	9	None	-151356	12	Rat	4.9	pKi	=	4.9	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	476	6	1	7	3.6	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1cccc(c1)C	10.1016/s0960-894x(01)00159-7
		2284	9956	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		4926	9956	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		7281	9956	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		CHEMBL564	9956	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		DB00420	9956	33	None	-36	29	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	nan
		44415582	145768	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	444	1	0	4	5.3	Cc1ccccc1C(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL378543	145768	0	None	3	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	444	1	0	4	5.3	Cc1ccccc1C(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		681	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		940	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		947	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		CHEMBL59	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		DB00988	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2009.04.047
		44241581	20793	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1197218	20793	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL562935	20793	0	None	-81	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	373	2	3	4	4.6	CCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		3032727	20248	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		CHEMBL1193245	20248	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		CHEMBL544618	20248	1	None	-562	2	Rat	6.9	pKi	=	6.9	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	281	1	2	3	3.2	CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		74223828	136221	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	4	1	6	3.8	COc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
		CHEMBL3671299	136221	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	4	1	6	3.8	COc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncnc1C	nan
		10519436	17998	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL1178784	17998	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL41238	17998	0	None	-1	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1scc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		10664137	169534	0	None	10	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL417164	169534	0	None	10	2	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		15711851	20312	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		CHEMBL1193797	20312	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		CHEMBL545264	20312	0	None	2	3	Goldfish	6.9	pKi	=	6.9	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		9838572	70227	0	None	-23	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	279	1	0	3	2.6	CN1CCN(C2=Cc3ccccc3Cn3cccc32)CC1	10.1021/jm049629t
		CHEMBL179775	70227	0	None	-23	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	279	1	0	3	2.6	CN1CCN(C2=Cc3ccccc3Cn3cccc32)CC1	10.1021/jm049629t
		10072800	103437	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL263790	103437	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL554199	103437	4	None	-6	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	384	4	0	5	4.7	O=C1c2ccsc2CC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		12050193	209975	0	None	-2	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	443	5	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL64325	209975	0	None	-2	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	443	5	0	5	4.9	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		12050199	107589	0	None	-32	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	7	1	5	4.9	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL293225	107589	0	None	-32	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	7	1	5	4.9	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		10068602	106979	1	None	-4677	3	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	384	6	0	4	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL28831	106979	1	None	-4677	3	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	384	6	0	4	3.1	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
		71528209	93747	0	None	-1949	7	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		CHEMBL2323582	93747	0	None	-1949	7	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	465	6	0	3	5.8	CC1=CC(C)=[N+]2C1=C(c1ccc(OCCCN3CCCCC3)cc1)c1c(C)cc(C)n1[B-]2(F)F	10.1021/ml300383n
		57398351	76933	0	None	-13	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	347	6	0	2	5.1	Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940406	76933	0	None	-13	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	347	6	0	2	5.1	Fc1ccc(OCCCN2CCC(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		10801923	184543	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	269	2	2	3	2.7	COc1cc2c(cc1O)C(c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4642805	184543	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	269	2	2	3	2.7	COc1cc2c(cc1O)C(c1ccccc1)CNCC2	10.1016/j.bmcl.2020.127305
		44555445	206708	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)Cc1ccccc1C2	10.1016/j.bmc.2009.08.028
		CHEMBL594789	206708	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)Cc1ccccc1C2	10.1016/j.bmc.2009.08.028
		127027739	144762	0	None	-11220	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	382	7	1	6	1.7	O=C(NCCCN1CCN(Cc2ccc3c(c2)OCO3)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		CHEMBL3764390	144762	0	None	-11220	3	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	382	7	1	6	1.7	O=C(NCCCN1CCN(Cc2ccc3c(c2)OCO3)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		60167166	82070	0	None	-41	8	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL2037430	82070	0	None	-41	8	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	371	5	0	4	4.7	Clc1ccc(N2CCN(CCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
		441383	27105	57	None	-12	17	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		CHEMBL1306	27105	57	None	-12	17	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	nan
		154705038	183425	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4584481	183425	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4598001	183425	1	None	-38	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.2	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		145967904	171876	0	None	-11	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	247	6	1	2	3.8	CCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4227192	171876	0	None	-11	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	247	6	1	2	3.8	CCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		145988180	172010	0	None	-10	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	10	1	2	5.3	CCCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4229178	172010	0	None	-10	6	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	10	1	2	5.3	CCCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		72699716	121967	0	None	-16	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344459	121967	0	None	-16	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		44326751	115392	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
		CHEMBL320572	115392	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
		CHEMBL539544	115392	0	None	-2	4	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	384	3	0	5	4.7	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2sccc21	10.1021/jm981094e
		24949690	188385	0	None	-1819	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
		CHEMBL477200	188385	0	None	-1819	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
		154705015	183293	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4454380	183293	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4596929	183293	1	None	-295	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4576555	220796	5	None	-1	19	Human	5.9	pKi	=	5.9	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		9930475	213069	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL87026	213069	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm981094e
		9930475	213069	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm00042a009
		CHEMBL87026	213069	0	None	-32	4	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	393	5	0	3	4.9	O=C(c1ccc(F)cc1)C1CCN(CCC2CCCc3ccccc3C2=O)CC1	10.1021/jm00042a009
		91899761	136227	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	317	3	1	5	3.8	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
		CHEMBL3671304	136227	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	317	3	1	5	3.8	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
		15937725	123883	0	None	158	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	279	1	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C(C2CCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL339342	123883	0	None	158	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	279	1	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C(C2CCCC2)C1	10.1016/S0960-894X(00)80155-9
		44415615	146313	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL379560	146313	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		44415507	87062	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		CHEMBL214016	87062	0	None	87	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		10710466	163194	0	None	11	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL40667	163194	0	None	11	2	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		74223725	136196	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C	nan
		CHEMBL3671275	136196	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C	nan
		117774412	139233	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.5	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)F	nan
		CHEMBL3697595	139233	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.5	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)F	nan
		44281202	107181	3	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	379	1	1	2	3.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		CHEMBL290118	107181	3	None	-	1	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	379	1	1	2	3.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00127a005
		44320061	112809	0	None	75	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL313304	112809	0	None	75	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	397	2	3	4	3.0	NC[C@@H]1OC(c2ccc(I)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		17755866	149662	1	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm070388+
		CHEMBL389356	149662	1	None	1	5	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm070388+
		681	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		940	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		947	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		CHEMBL59	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		DB00988	8247	72	None	-154	38	Human	6.9	pKi	=	6.9	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00018a002
		15115517	16485	0	None	-426	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL113196	16485	0	None	-426	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		6852376	98374	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
		CHEMBL1467585	98374	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
		CHEMBL24077	98374	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
		CHEMBL503958	98374	13	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00115a012
		2865	10915	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		59	10915	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		60854	10915	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL708	10915	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB00246	10915	73	None	-114	53	Human	6.9	pKi	=	6.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1016/j.bmc.2008.06.030
		146025727	178464	0	None	-4	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4466483	178464	0	None	-4	27	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	411	3	0	5	6.4	FC(F)(F)c1cc(Oc2nccc3ccsc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		44415686	86754	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	7	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212700	86754	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	7	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		24800527	162499	0	None	-4	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	1	3	3.5	CCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		CHEMBL405369	162499	0	None	-4	2	Rat	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	1	3	3.5	CCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		57403525	76929	0	None	-85	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940402	76929	0	None	-85	10	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	361	6	1	2	4.8	OC1(c2ccc(Cl)cc2)CCN(CCCCc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		118709159	120182	0	None	-21	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	832	17	0	8	9.7	O=C(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318831	120182	0	None	-21	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	832	17	0	8	9.7	O=C(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		2337	10030	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		50	10030	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		5002	10030	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL716	10030	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB01224	10030	77	None	-53	62	Human	5.9	pKi	=	5.9	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1016/j.bmc.2008.06.030
		44403219	78679	0	None	-1174	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)nc1	10.1016/j.bmcl.2005.07.037
		CHEMBL197162	78679	0	None	-1174	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)nc1	10.1016/j.bmcl.2005.07.037
		10448562	121898	1	None	12	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL334350	121898	1	None	12	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		16105549	74560	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
		CHEMBL1908879	74560	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
		CHEMBL221640	74560	0	None	-2884	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(F)nc3)cc2)CC1	10.1021/jm0611152
		71459759	90846	0	None	-81	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	432	4	0	3	5.5	COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207633	90846	0	None	-81	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	432	4	0	3	5.5	COc1ccccc1N1CCN(Cc2cc(C#Cc3ccccc3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		44567686	198846	0	None	-1	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	265	1	0	2	3.4	COc1cc2c3c(c1)-c1ccccc1C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.06.016
		CHEMBL520262	198846	0	None	-1	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	265	1	0	2	3.4	COc1cc2c3c(c1)-c1ccccc1C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.06.016
		53327663	73253	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1852239	73253	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL3215641	73253	0	None	-134	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	342	3	3	5	2.9	CN1CCc2cc(SCCN)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		137643309	165194	0	None	-1174	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccn2ncc(C=O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4090208	165194	0	None	-1174	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccn2ncc(C=O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		122181326	128645	0	None	-426	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	413	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.12.012
		CHEMBL3590077	128645	0	None	-426	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	413	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)/N=N/c2ccc(F)cc2)CC1	10.1016/j.bmc.2014.12.012
		122181329	128648	0	None	-4168	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	394	10	1	2	4.6	CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		CHEMBL3590080	128648	0	None	-4168	6	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	394	10	1	2	4.6	CCCN(CCCCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		57402787	75970	0	None	-371	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	977	28	2	17	4.4	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1926700	75970	0	None	-371	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	977	28	2	17	4.4	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		9995904	37993	4	None	-14454	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm060166w
		CHEMBL140099	37993	4	None	-14454	5	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm060166w
		11626748	146937	0	None	-14	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	459	4	0	7	3.1	CN1CCN(c2ccc3nc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cn3n2)CC1	10.1021/jm060166w
		CHEMBL380287	146937	0	None	-14	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	459	4	0	7	3.1	CN1CCN(c2ccc3nc(CN4CCN(c5ccc(Cl)c(Cl)c5)CC4)cn3n2)CC1	10.1021/jm060166w
		44340186	16432	0	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
		CHEMBL112831	16432	0	None	-45	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
		9995904	37993	4	None	-14454	5	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm0009989
		CHEMBL140099	37993	4	None	-14454	5	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4)CC3)cc2c1	10.1021/jm0009989
		25139180	191120	0	None	-42	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	490	10	1	2	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
		CHEMBL484357	191120	0	None	-42	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	490	10	1	2	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
		25099152	194065	0	None	-38	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	466	9	2	5	5.1	CCCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c2ccccc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL492883	194065	0	None	-38	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	466	9	2	5	5.1	CCCN(CC[C@H]1CC[C@H](NC(=O)/C=C/c2ccccc2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		25130817	194291	0	None	-37	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	518	9	2	5	6.5	CC(C)CCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL494309	194291	0	None	-37	2	Rat	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	518	9	2	5	6.5	CC(C)CCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		73347474	97834	0	None	-12882	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
		CHEMBL2397478	97834	0	None	-12882	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
		137655556	165318	0	None	-3801	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	2	7	3.3	O=c1ccc2c(N3CCCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
		CHEMBL4091507	165318	0	None	-3801	5	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	2	7	3.3	O=c1ccc2c(N3CCCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
		71733935	97758	0	None	-30902	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
		CHEMBL2396663	97758	0	None	-30902	6	Human	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
		14665503	98009	0	None	-21379	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	382	7	1	4	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		CHEMBL240106	98009	0	None	-21379	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	382	7	1	4	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		44437896	159247	0	None	-1174	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	400	6	1	3	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)ccc1OC	10.1016/j.bmc.2007.07.017
		CHEMBL397103	159247	0	None	-1174	4	Pig	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	400	6	1	3	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)ccc1OC	10.1016/j.bmc.2007.07.017
		44329283	214420	0	None	-30	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@H]1CCn2c(CO)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL95230	214420	0	None	-30	3	Bovine	4.9	pKi	=	4.9	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	250	6	1	3	2.4	CCCN(CCC)[C@H]1CCn2c(CO)ccc2C1	10.1016/s0960-894x(01)00564-9
		53321194	65376	0	None	-56	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684135	65376	0	None	-56	3	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		154724650	183116	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4543870	183116	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595492	183116	1	None	-74	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		154706711	183294	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4439535	183294	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596930	183294	1	None	-48	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		10024430	214392	0	None	-41	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL95098	214392	0	None	-41	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	8	0	4	3.9	O=C(CCCN1CCN(CCC2Cc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		135398737	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		38	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		722	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		CHEMBL42	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		DB00363	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.034
		135398737	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		38	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		722	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		CHEMBL42	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		DB00363	7745	93	None	-44	90	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2006.06.022
		156011597	184158	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4637938	184158	0	None	3	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		72699717	121968	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	5	1	4	4.9	CCCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344460	121968	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	5	1	4	4.9	CCCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		2600	10551	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		2608	10551	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		5405	10551	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		CHEMBL17157	10551	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		DB00342	10551	74	None	-7	13	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	nan
		57393083	76942	0	None	-21	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	314	6	0	4	2.8	Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940415	76942	0	None	-21	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	314	6	0	4	2.8	Fc1ccc(CCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		45483261	204665	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	380	3	0	6	3.4	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2ncncc21	10.1016/j.bmcl.2009.09.041
		CHEMBL572708	204665	0	None	-5	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	380	3	0	6	3.4	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2ncncc21	10.1016/j.bmcl.2009.09.041
		11795165	16141	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL111352	16141	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL541842	16141	1	None	-3	3	Rat	6.9	pKi	=	6.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2sccc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		45267373	20790	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1197201	20790	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL562460	20790	0	None	-11	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	295	1	2	3	3.5	CCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		44278589	105226	0	None	-11	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@@H]1Cc1ccccc1-3	10.1021/jm00402a024
		CHEMBL27574	105226	0	None	-11	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@@H]1Cc1ccccc1-3	10.1021/jm00402a024
		5311191	119408	7	None	-35	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		CHEMBL330274	119408	7	None	-35	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		15021875	111146	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm00111a046
		CHEMBL310153	111146	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm00111a046
		15021875	111146	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm981094e
		CHEMBL310153	111146	0	None	-208	5	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	350	4	0	4	3.3	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc3C2)CC1	10.1021/jm981094e
		10645469	117334	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL325253	117334	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL542428	117334	0	None	-5	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	414	7	0	5	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccsc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		9979654	214698	0	None	-14	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL96781	214698	0	None	-14	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	422	8	0	4	4.2	O=C(CCCN1CCN(CCC2CCc3ccccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		155516042	183072	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4443039	183072	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4595150	183072	0	None	-891	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		12442999	94285	6	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2334890	94285	6	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		57391307	76938	0	None	-19	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	348	6	0	3	4.1	Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940411	76938	0	None	-19	7	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	348	6	0	3	4.1	Fc1ccc(OCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		71722301	109250	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
		CHEMBL3040157	109250	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
		CHEMBL3216146	109250	0	None	-2	3	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	400	3	2	4	4.5	CN(C)c1ccc(Cc2ccc3c4c2-c2c(ccc(O)c2O)C[C@H]4N(C)CC3)cc1	10.1016/j.bmc.2013.05.014
		53324045	63845	0	None	-3	16	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL1644980	63845	0	None	-3	16	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	487	7	1	2	7.3	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccccc2)c2ccccc2)CC1	10.1016/j.bmcl.2018.10.036
		44358192	208922	5	None	-676	2	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	345	1	2	2	2.3	CN1C[C@H](C(N)=O)C=C2c3cccc4[nH]c(Br)c(c34)C[C@H]21	10.1021/jm9800292
		CHEMBL609151	208922	5	None	-676	2	Human	5.9	pKi	=	5.9	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	345	1	2	2	2.3	CN1C[C@H](C(N)=O)C=C2c3cccc4[nH]c(Br)c(c34)C[C@H]21	10.1021/jm9800292
		10862670	25274	0	None	-281	4	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
		CHEMBL126439	25274	0	None	-281	4	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
		CHEMBL127317	25274	0	None	-281	4	Rat	5.9	pKi	=	5.9	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccccc3n2)CC1	10.1021/jm0211220
		15467373	108631	0	None	-107	4	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(99)00302-9
		CHEMBL300553	108631	0	None	-107	4	Bovine	4.9	pKi	=	4.9	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(99)00302-9
		53946795	74507	1	None	-1122	2	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
		CHEMBL1907814	74507	1	None	-1122	2	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
		136074292	210349	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cnccc3Nc3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL66730	210349	0	None	-3	2	Rat	4.9	pKi	=	4.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cnccc3Nc3ccccc32)CC1	10.1021/jm00067a009
		44304652	207101	0	None	-28	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL59749	207101	0	None	-28	4	Bovine	4.9	pKi	=	4.9	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
		71062646	156322	0	None	-2238	13	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		CHEMBL3946661	156322	0	None	-2238	13	Mouse	5.9	pKi	=	5.9	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	338	6	0	4	2.8	c1ccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)cc1	nan
		13373172	206562	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	251	0	1	2	3.0	Oc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
		CHEMBL593897	206562	0	None	-3	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	251	0	1	2	3.0	Oc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
		17756212	93143	1	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
		CHEMBL231374	93143	1	None	-1	5	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
		2286	9957	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		4927	9957	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		7282	9957	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		CHEMBL643	9957	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		DB01069	9957	51	None	-30	30	Human	5.9	pKi	=	5.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	nan
		11080	35858	79	None	-5	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		CHEMBL1381098	35858	79	None	-5	6	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	185	1	0	2	3.6	S=C=Nc1cccc2ccccc12	nan
		44210226	123309	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
		CHEMBL336218	123309	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
		117773821	139239	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	1	4	4.0	Cc1cc(Oc2ncc(F)cc2C)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697601	139239	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	1	4	4.0	Cc1cc(Oc2ncc(F)cc2C)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		10851717	85252	1	None	-15	4	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	85252	1	None	-15	4	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		154725484	183244	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4439544	183244	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4596514	183244	1	None	-630	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)C[C@@H]1C[C@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		9970201	177422	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
		CHEMBL445129	177422	0	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
		168295528	199810	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5206565	199810	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222872	199810	0	None	-338	20	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	333	6	4	5	0.9	N/C(=N\C(=O)NCc1ccccc1)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		10249506	15577	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL109673	15577	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL544091	15577	0	None	-6	4	Rat	5.9	pKi	=	5.9	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		10851717	85252	1	None	-15	4	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	85252	1	None	-15	4	Rat	6.9	pKi	=	6.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		155770281	184526	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4642592	184526	0	None	-1	9	Human	5.9	pKi	=	5.9	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	517	4	1	2	7.6	CC(=O)N1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		23656544	176890	0	None	-575	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	2	3	2.6	CN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		CHEMBL444368	176890	0	None	-575	3	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	2	3	2.6	CN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		5352624	74013	44	None	-3	5	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
		CHEMBL18797	74013	44	None	-3	5	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	340	4	1	2	5.4	CSc1ccc(/C=C2/C(C)=C(CC(=O)O)c3cc(F)ccc32)cc1	nan
		2662	18156	131	None	-3	30	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
		CHEMBL118	18156	131	None	-3	30	Human	4.9	pKi	=	4.9	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	nan
		16104	168696	19	None	-1	5	Rat	7.9	pKi	=	7.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00043a008
		CHEMBL415300	168696	19	None	-1	5	Rat	7.9	pKi	=	7.9	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00043a008
		44415544	87012	0	None	169	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Br)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213775	87012	0	None	169	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Br)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415628	146570	0	None	104	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccs3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL379874	146570	0	None	104	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccs3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		156017431	184556	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
		CHEMBL4643069	184556	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	317	2	1	3	3.7	COc1cc2c(cc1O)C(c1ccccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
		10981731	22041	0	None	-3	2	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL121274	22041	0	None	-3	2	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		11014679	121566	0	None	-3	2	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL333955	121566	0	None	-3	2	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		16351	109507	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		CHEMBL304902	109507	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		9841398	106295	4	None	3	4	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL28338	106295	4	None	3	4	Rat	7.9	pKi	=	7.9	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		44320024	113844	0	None	51	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL315750	113844	0	None	51	2	Rat	7.9	pKi	=	7.9	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	291	3	3	4	2.9	CNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		86767093	136201	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
		CHEMBL3671280	136201	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
		16351	109507	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		CHEMBL304902	109507	47	None	-4	6	Rat	7.9	pKi	=	7.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		11014679	121566	0	None	-3	2	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL333955	121566	0	None	-3	2	Rat	7.9	pKi	=	7.9	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	391	2	0	4	4.1	CCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		10981731	22041	0	None	-3	2	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL121274	22041	0	None	-3	2	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	377	1	0	4	3.7	CN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		44276412	104441	0	None	10	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL27117	104441	0	None	10	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		44276556	106478	0	None	30	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL284644	106478	0	None	30	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3ccncc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		45482180	204683	0	None	-17	4	Pig	6.9	pKi	=	6.9	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	544	12	1	7	4.6	COc1ccc(-n2cc(CCCC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
		CHEMBL572867	204683	0	None	-17	4	Pig	6.9	pKi	=	6.9	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	544	12	1	7	4.6	COc1ccc(-n2cc(CCCC(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
		130442480	182049	0	None	-1	24	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		CHEMBL4572614	182049	0	None	-1	24	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	410	3	0	6	5.7	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1C(F)(F)F	10.1021/acs.jmedchem.9b00351
		53328903	73232	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
		CHEMBL1802237	73232	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
		CHEMBL1852107	73232	0	None	2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	353	0	2	5	3.5	CN1CCc2c3c(cc4c2[C@H]1Cc1ccc(O)c(O)c1-4)SCCC3=O	10.1016/j.ejmech.2011.04.028
		52919	21222	48	None	-15	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL1200986	21222	48	None	-15	4	Pig	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		14198590	210165	1	None	-1	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00118a012
		CHEMBL65397	210165	1	None	-1	4	Rat	6.9	pKi	=	6.9	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00118a012
		10895106	39001	0	None	-27	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		CHEMBL140968	39001	0	None	-27	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	421	9	1	6	3.1	COc1ccccc1N1CCN(CCCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		10053476	123524	0	None	-2570	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	559	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[te]1	10.1021/jm025558r
		CHEMBL337531	123524	0	None	-2570	5	Human	5.9	pKi	=	5.9	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	559	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[te]1	10.1021/jm025558r
		44454707	104607	0	None	-28	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2007.12.026
		CHEMBL272073	104607	0	None	-28	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmcl.2007.12.026
		44393411	72867	0	None	-316	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	587	7	1	4	6.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2s1	10.1016/j.bmcl.2004.05.052
		CHEMBL183871	72867	0	None	-316	5	Pig	5.9	pKi	=	5.9	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	587	7	1	4	6.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2s1	10.1016/j.bmcl.2004.05.052
		71459760	90847	0	None	-74	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	398	5	0	3	5.3	CCCC#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
		CHEMBL2207634	90847	0	None	-74	5	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	398	5	0	3	5.3	CCCC#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
		25072941	163253	0	None	-331	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4067439	163253	0	None	-331	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccc3c(C=O)cnn3c2)CC1	10.1021/acs.jmedchem.6b01857
		137640371	163593	0	None	-933	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccc2c(C=O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4071185	163593	0	None	-933	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	421	10	1	6	4.3	CCCN(CCCCOc1ccc2c(C=O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		118709165	120188	0	None	-66	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	916	23	0	8	12.1	O=C(CCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318837	120188	0	None	-66	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	916	23	0	8	12.1	O=C(CCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		118709167	120190	0	None	-16	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	972	27	0	8	13.6	O=C(CCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318839	120190	0	None	-16	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	972	27	0	8	13.6	O=C(CCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		118709170	120194	0	None	-53	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1057	33	0	8	16.0	O=C(CCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318842	120194	0	None	-53	4	Pig	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1057	33	0	8	16.0	O=C(CCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		44372296	126265	0	None	-72	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1	10.1016/s0960-894x(01)00814-9
		CHEMBL345357	126265	0	None	-72	4	Bovine	5.9	pKi	=	5.9	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1ccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn2c1	10.1016/s0960-894x(01)00814-9
		CHEMBL5074765	221111	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		O=C(O)c1cc(-c2ccc([C@@H]3C[C@@H]4C[C@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
		CHEMBL5079653	221410	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		O=C(O)c1cc(-c2ccc([C@H]3C[C@H]4C[C@@H]3NC4=O)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
		CHEMBL5085145	221730	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		N[C@H]1C[C@@H](CO)[C@H](c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)C1	10.1021/acs.jmedchem.1c01964
		CHEMBL5087121	221849	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Inhibition of dopamine D1 receptor (unknown origin) assessed as binding constantInhibition of dopamine D1 receptor (unknown origin) assessed as binding constant	ChEMBL		None	None	None		CN(C)C(=O)COC(=O)c1cc(-c2ccc([C@H]3C[C@H]4C[C@@H]3CN4)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc2c1	10.1021/acs.jmedchem.1c01964
		44380774	127253	0	None	-851	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL354180	127253	0	None	-851	4	Bovine	4.9	pKi	=	4.9	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		44336571	11603	0	None	-61	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
		CHEMBL104201	11603	0	None	-61	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
		15508239	13028	0	None	-5	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	336	3	0	2	4.6	C[Si](C)(C)C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL108160	13028	0	None	-5	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	336	3	0	2	4.6	C[Si](C)(C)C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		15508240	117304	0	None	-15	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	264	3	0	2	3.3	C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL325104	117304	0	None	-15	4	Bovine	4.9	pKi	=	4.9	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	264	3	0	2	3.3	C#Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		10496727	20034	0	None	-24	3	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	331	2	0	3	4.7	COc1c(-c2ccco2)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL119150	20034	0	None	-24	3	Rat	4.9	pKi	=	4.9	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	331	2	0	3	4.7	COc1c(-c2ccco2)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		90644066	118817	0	None	-17	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	5	0	3	4.8	Clc1ccc(N2CCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289653	118817	0	None	-17	4	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	5	0	3	4.8	Clc1ccc(N2CCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		53328721	73209	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1851968	73209	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL3216523	73209	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		279	8442	26	None	-29	17	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
		49381	8442	26	None	-29	17	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
		CHEMBL63756	8442	26	None	-29	17	Rat	6.9	pKi	=	6.9	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00067a009
		279	8442	26	None	-29	17	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
		49381	8442	26	None	-29	17	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
		CHEMBL63756	8442	26	None	-29	17	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	10.1021/jm00030a011
		44210226	123309	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
		CHEMBL336218	123309	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	1	2	4.0	CN1Cc2ccccc2C2c3cc(O)c(Br)cc3CCC21	10.1021/jm00051a008
		14198588	178286	2	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		CHEMBL446396	178286	2	None	2	2	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		14198590	210165	1	None	1	4	Human	6.9	pKi	=	6.9	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00129a006
		CHEMBL65397	210165	1	None	1	4	Human	6.9	pKi	=	6.9	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@H]2c1ccccc1	10.1021/jm00129a006
		44582676	196558	0	None	-10	17	Human	5.9	pKi	=	5.9	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL516088	196558	0	None	-10	17	Human	5.9	pKi	=	5.9	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	403	9	0	4	4.3	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		13922235	106316	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
		CHEMBL283489	106316	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
		13922235	106316	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		CHEMBL283489	106316	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		13922235	106316	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		CHEMBL283489	106316	1	None	-23	2	Rat	5.9	pKi	=	5.9	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		10433336	85293	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	439	8	1	4	4.3	BC#N.CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL2111925	85293	0	None	-	1	Rat	6.9	pKi	=	6.9	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	439	8	1	4	4.3	BC#N.CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		135	9310	43	None	-46	56	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		1796	9310	43	None	-46	56	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		4184	9310	43	None	-46	56	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		CHEMBL6437	9310	43	None	-46	56	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		DB06148	9310	43	None	-46	56	Rat	5.9	pKi	=	5.9	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	10.1021/jm049632c
		5320227	102612	59	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	354	6	1	5	4.6	CC(C)=CC(O)C/C(C)=C/COc1c2ccoc2cc2oc(=O)ccc12	10.1016/j.bmc.2007.12.021
		CHEMBL258939	102612	59	None	-	1	Rat	5.9	pKi	=	5.9	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	354	6	1	5	4.6	CC(C)=CC(O)C/C(C)=C/COc1c2ccoc2cc2oc(=O)ccc12	10.1016/j.bmc.2007.12.021
		154706461	183127	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4470439	183127	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595600	183127	1	None	-60	5	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	6.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		44537925	205523	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL582945	205523	0	None	-1	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	624	12	2	9	5.2	COc1ccccc1N1CCN(CCCn2cc(CCCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		156010755	183920	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	351	2	1	3	4.3	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
		CHEMBL4633950	183920	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	351	2	1	3	4.3	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CN(C)CC2	10.1016/j.bmcl.2020.127305
		11112574	25279	0	None	-17	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	419	8	1	6	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3n2)CC1	10.1021/jm0211220
		CHEMBL127344	25279	0	None	-17	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	419	8	1	6	3.0	COc1ccccc1N1CCN(CCCCNC(=O)c2cnc3ccccc3n2)CC1	10.1021/jm0211220
		10732337	119768	0	None	-13	3	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	291	2	0	2	4.1	C=Cc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL331100	119768	0	None	-13	3	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	291	2	0	2	4.1	C=Cc1ccc2c(c1OC)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		70684207	82845	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057452	82845	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70684207	82845	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057452	82845	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)C1Cc3cc(C)cc(C)c3CN1CC2	nan
		31101	7516	40	None	-436	35	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		35	7516	40	None	-436	35	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		403	7516	40	None	-436	35	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		CHEMBL493	7516	40	None	-436	35	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		DB01200	7516	40	None	-436	35	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	nan
		44582490	196916	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	4.2	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL517349	196916	0	None	-6	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	4.2	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		1353	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		3559	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		86	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		CHEMBL54	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		DB00502	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9810396
		196129	74573	17	None	-1819	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		CHEMBL1909065	74573	17	None	-1819	15	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	917	13	4	16	4.3	CO[C@H]1C[C@@H](O[C@H]2C[C@H]([C@H]3O[C@](C)(O)[C@H](C)C[C@@H]3C)O[C@H]2[C@]2(C)CC[C@H]([C@]3(C)CC[C@]4(C[C@H](O)[C@@H](C)[C@@H]([C@@H](C)[C@@H]5O[C@](O)(CC(=O)O)[C@@H](C)[C@H](OC)[C@H]5OC)O4)O3)O2)O[C@@H](C)[C@@H]1OC	nan
		154704368	183250	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4569006	183250	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596571	183250	1	None	-31	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	421	11	2	2	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		11408148	135498	0	None	-371	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		CHEMBL366904	135498	0	None	-371	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	443	6	1	4	4.8	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		154725234	183071	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		CHEMBL4585289	183071	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		CHEMBL4595149	183071	1	None	-2	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	472	12	0	6	5.2	CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		73453	36389	24	None	-208	17	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		CHEMBL1385840	36389	24	None	-208	17	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	nan
		33630	185736	99	None	-5	28	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL47050	185736	99	None	-5	28	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		2389	10104	118	None	-346	66	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		5073	10104	118	None	-346	66	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		96	10104	118	None	-346	66	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		CHEMBL85	10104	118	None	-346	66	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		DB00734	10104	118	None	-346	66	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm049632c
		156014482	183991	0	None	3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	303	2	2	3	3.3	COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4635423	183991	0	None	3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	303	2	2	3	3.3	COc1cc2c(cc1O)C(c1ccccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
		2389	10104	118	None	-489	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		5073	10104	118	None	-489	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		96	10104	118	None	-489	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		CHEMBL85	10104	118	None	-489	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		DB00734	10104	118	None	-489	66	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmcl.2009.09.041
		21589014	150850	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL3903297	150850	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	0	0	5	2.8	c1c2c(cc3c1OCO3)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		10044334	213900	18	None	-64	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL92145	213900	18	None	-64	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	364	5	0	4	3.7	COc1ccccc1N1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
		44415568	146921	0	None	9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C(F)(F)F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL380236	146921	0	None	9	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C(F)(F)F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		155529453	178217	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranesDisplacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranes	ChEMBL	385	4	2	3	4.3	COc1ccc2[nH]cc(C3=CCN(Cc4cc(=O)[nH]c5ccccc45)CC3)c2c1	10.1016/j.ejmech.2019.07.050
		CHEMBL4463034	178217	0	None	-2	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranesDisplacement of [3H]SCH23390 from human D1 receptor expressed in commercial cell membranes	ChEMBL	385	4	2	3	4.3	COc1ccc2[nH]cc(C3=CCN(Cc4cc(=O)[nH]c5ccccc45)CC3)c2c1	10.1016/j.ejmech.2019.07.050
		11406143	72906	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	372	7	0	3	4.5	c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm049720x
		CHEMBL184073	72906	0	None	-2	4	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	372	7	0	3	4.5	c1ccc(Cc2ccccc2OCCN2CCN(c3ccccc3)CC2)cc1	10.1021/jm049720x
		10895039	25292	0	None	-1000	7	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		CHEMBL127400	25292	0	None	-1000	7	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		CHEMBL129022	25292	0	None	-1000	7	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	418	8	1	5	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3cn2)CC1	10.1021/jm0211220
		44593524	190835	0	None	-12	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.11.025
		CHEMBL482276	190835	0	None	-12	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	365	5	0	4	4.5	CCCCC(=O)Oc1cccc2c1-c1cc(OC)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.11.025
		10740666	32895	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	416	6	1	3	4.5	CN(C)CCCCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL135616	32895	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	416	6	1	3	4.5	CN(C)CCCCN1CCc2cc(Br)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL4576555	220796	5	None	-1	19	Human	5.8	pKi	=	5.8	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL4507307
		CHEMBL4576555	220796	5	None	-1	19	Human	5.8	pKi	=	5.8	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000705a DRD1	ChEMBL		None	None	None		CN1CCN(C(=O)C(C)(C)c2ccc(C(=O)Nc3cn4cc(-c5cc(C(C)(C)C)cc(C(C)(C)C)c5)ccc4n3)cc2)CC1	10.6019/CHEMBL5212743
		117773324	139209	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2cc(C3CC3)ccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697572	139209	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2cc(C3CC3)ccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		1218	10388	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		938	10388	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		CHEMBL353335	10388	30	None	-11	8	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/acsmedchemlett.9b00050
		44415611	173038	0	None	54	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	435	2	1	6	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccco3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL426868	173038	0	None	54	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	435	2	1	6	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccco3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11567963	161834	0	None	40	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	419	3	1	5	3.9	COc1cc2c(cc1OC)-c1c(OC)c(O)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL401689	161834	0	None	40	2	Rat	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	419	3	1	5	3.9	COc1cc2c(cc1OC)-c1c(OC)c(O)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		10220	145538	16	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)C1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		CHEMBL3780481	145538	16	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)C1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		86763997	139251	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697613	139251	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		9884087	21409	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	21409	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		86767098	136208	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		CHEMBL3671287	136208	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		130442572	178687	0	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		CHEMBL4469848	178687	0	None	-3	24	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cells measured after 90 mins by microbeta scintillation counting method	ChEMBL	395	3	0	5	6.0	FC(F)(F)c1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.9b00351
		44415395	144939	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	423	2	1	5	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL376928	144939	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	423	2	1	5	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		53328901	73255	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1802236	73255	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1852245	73255	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	371	4	3	5	3.4	CN1CCc2cc(SCCC(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		90644226	118556	0	None	-72	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287395	118556	0	None	-72	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	490	9	0	7	4.8	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		118709179	120203	0	None	-61	4	Pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1198	35	0	18	9.5	O=C(CCc1cn(CCOCCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318851	120203	0	None	-61	4	Pig	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1198	35	0	18	9.5	O=C(CCc1cn(CCOCCOCCOCCOCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		681	8247	72	None	-97	38	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		940	8247	72	None	-97	38	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		947	8247	72	None	-97	38	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		CHEMBL59	8247	72	None	-97	38	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		DB00988	8247	72	None	-97	38	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a018
		10546131	107185	0	None	20	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL290149	107185	0	None	20	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3cc(C4CCCCC4)sc3CN[C@H]1CC2	10.1021/jm970038v
		10476504	40261	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		CHEMBL142020	40261	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm025558r
		44361021	125564	0	None	-537	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1	10.1021/jm025558r
		CHEMBL342060	125564	0	None	-537	6	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccn3nccc3c2)CC1	10.1021/jm025558r
		10884046	172148	0	None	-107	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		CHEMBL423735	172148	0	None	-107	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		44436602	151991	0	None	-245	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL391256	151991	0	None	-245	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2007.08.038
		44436598	156074	0	None	-3388	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL394473	156074	0	None	-3388	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1cccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		53361302	70624	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
		CHEMBL1803049	70624	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2009919
		11696910	84522	0	None	-1174	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	395	3	0	5	4.0	Clc1ccc2nc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cn2n1	10.1021/jm060166w
		CHEMBL209034	84522	0	None	-1174	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	395	3	0	5	4.0	Clc1ccc2nc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)cn2n1	10.1021/jm060166w
		53361302	70624	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803049	70624	0	None	-208	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	493	13	0	8	4.4	CCCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		45268292	203466	0	None	-446	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	460	4	1	6	3.5	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL564688	203466	0	None	-446	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	460	4	1	6	3.5	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		71583848	94506	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		CHEMBL2336892	94506	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		137636498	162975	0	None	-660	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	446	7	2	6	3.8	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4064186	162975	0	None	-660	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	446	7	2	6	3.8	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5ncccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		118709171	120195	0	None	-5	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1085	35	0	8	16.8	O=C(CCCCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318843	120195	0	None	-5	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1085	35	0	8	16.8	O=C(CCCCCCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		122189389	130022	0	None	-346	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	497	8	0	8	4.2	O=Cc1cnn2ccc(-n3cc(CCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		CHEMBL3613875	130022	0	None	-346	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	497	8	0	8	4.2	O=Cc1cnn2ccc(-n3cc(CCCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		13678304	108490	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	229	3	3	3	2.3	NCCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
		CHEMBL299511	108490	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	229	3	3	3	2.3	NCCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
		44371996	60397	0	None	-8	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	500	6	0	6	4.6	Clc1ccc(N2CCN(Cc3cnn4c(N5CCN(Cc6ccccc6)CC5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		CHEMBL160266	60397	0	None	-8	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	500	6	0	6	4.6	Clc1ccc(N2CCN(Cc3cnn4c(N5CCN(Cc6ccccc6)CC5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		44371980	60709	0	None	-57	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	514	6	0	6	4.9	Cc1nn2c(N3CCN(Cc4ccccc4)CC3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		CHEMBL160536	60709	0	None	-57	4	Bovine	5.8	pKi	=	5.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	514	6	0	6	4.9	Cc1nn2c(N3CCN(Cc4ccccc4)CC3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		44400674	131967	0	None	-3019	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL364516	131967	0	None	-3019	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		44264623	211792	0	None	-1174	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL7686	211792	0	None	-1174	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnc4ccccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		11659604	145352	0	None	-30	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4ccncc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL377542	145352	0	None	-30	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4ccncc4n3)CC2)cc1	10.1021/jm060166w
		44336552	118117	1	None	-53	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL326864	118117	1	None	-53	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	316	4	0	4	3.8	N#CC(C#N)=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		9977478	211722	2	None	-234422	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	386	6	2	5	2.4	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		CHEMBL76402	211722	2	None	-234422	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	386	6	2	5	2.4	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Br)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		56926586	75784	0	None	-2089	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	344	3	1	5	2.6	Oc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
		CHEMBL1923415	75784	0	None	-2089	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	344	3	1	5	2.6	Oc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
		44381217	65920	0	None	-9	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
		CHEMBL169889	65920	0	None	-9	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
		44371997	56704	0	None	-10000	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	364	3	0	4	3.6	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)c(C)nn12	10.1016/s0960-894x(01)00814-9
		CHEMBL156851	56704	0	None	-10000	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	364	3	0	4	3.6	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)c(C)nn12	10.1016/s0960-894x(01)00814-9
		154704941	183406	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4578364	183406	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4597877	183406	1	None	-47	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	470	11	0	6	5.8	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		167715	9651	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
		969	9651	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
		CHEMBL225230	9651	14	None	-194	5	Human	5.8	pKi	=	5.8	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm9800292
		46231834	207691	0	None	-117	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	488	3	1	5	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCN(c5ccccn5)CC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL601635	207691	0	None	-117	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	488	3	1	5	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCN(c5ccccn5)CC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		10684714	107086	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115372	107086	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL289283	107086	0	None	13	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL5289958	201265	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constantDisplacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constant	ChEMBL	429	4	1	2	5.6	Fc1ccc(CN2CCCC3(CCN(Cc4cc5ccc(Cl)cc5[nH]4)C3)C2)cc1F	10.1016/j.ejmech.2022.114840
		72301	192897	76	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		CHEMBL487182	192897	76	None	1	4	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		44415367	86723	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	411	3	1	5	3.9	CCCC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL212597	86723	0	None	2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	411	3	1	5	3.9	CCCC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		44401105	76351	0	None	-17	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193435	76351	0	None	-17	9	Human	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	373	2	0	3	4.7	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Br)cc3[C@H]2O1	10.1021/jm049632c
		44320327	170203	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL419680	170203	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	5	3	4	3.4	C=CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		10623632	55068	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	453	4	1	3	5.1	CCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
		CHEMBL155351	55068	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	453	4	1	3	5.1	CCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
		44326982	15431	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
		CHEMBL109548	15431	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
		CHEMBL545727	15431	0	None	-7	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	351	4	0	3	4.1	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)c2ccccc21	10.1021/jm981094e
		9886130	213209	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL87943	213209	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm981094e
		9886130	213209	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm00042a009
		CHEMBL87943	213209	0	None	-32	4	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	379	5	0	3	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccccc3C2=O)CC1	10.1021/jm00042a009
		131990	50719	11	None	-6	2	Rat	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cnccc3Sc3ccccc32)CC1	10.1021/jm00030a011
		CHEMBL151263	50719	11	None	-6	2	Rat	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cnccc3Sc3ccccc32)CC1	10.1021/jm00030a011
		156018868	184706	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	378	5	1	4	4.0	C=CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4645375	184706	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	378	5	1	4	4.0	C=CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		12050195	210063	0	None	-21	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	6	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL64696	210063	0	None	-21	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	6	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(Cc3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		11057	182928	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		3468	182928	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL459265	182928	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		CHEMBL64894	182928	23	None	-2	20	Human	5.8	pKi	=	5.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	nan
		117772791	139200	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	323	3	1	5	2.5	Cc1cc(Oc2ccccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697563	139200	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	323	3	1	5	2.5	Cc1cc(Oc2ccccn2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44415625	86870	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213145	86870	0	None	4	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		11732785	170499	0	None	-323	5	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
		CHEMBL420510	170499	0	None	-323	5	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	432	7	0	5	3.7	COc1ccccc1N1CCN(CCCCN2CCn3c(cc4ccccc43)C2=O)CC1	10.1021/jm0211220
		44278409	107110	0	None	-616	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	418	6	0	4	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL28946	107110	0	None	-616	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	418	6	0	4	3.8	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
		44415543	86725	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212608	86725	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415543	86725	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212608	86725	0	None	7	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	445	2	1	5	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		10052433	172136	0	None	-501	4	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	521	10	1	6	4.1	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		CHEMBL423671	172136	0	None	-501	4	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	521	10	1	6	4.1	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(S(C)(=O)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		16090821	88608	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL216439	88608	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
		10851717	85252	1	None	-15	4	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	85252	1	None	-15	4	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		1353	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		3559	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		86	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		CHEMBL54	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		DB00502	8692	93	None	-74	85	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm981094e
		9817779	121210	0	None	-2	2	Rat	6.8	pKi	=	6.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
		CHEMBL333246	121210	0	None	-2	2	Rat	6.8	pKi	=	6.8	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
		1830	9368	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		207	9368	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		23897	9368	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		CHEMBL460	9368	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		DB01618	9368	44	None	-16	28	Rat	5.8	pKi	=	5.8	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	10.1016/0960-894X(95)00076-6
		10851717	85252	1	None	-15	4	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL2111782	85252	1	None	-15	4	Rat	6.8	pKi	=	6.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN([C@@H]2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		44323894	174879	0	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	304	1	0	2	3.9	CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL432762	174879	0	None	-1	4	Rat	7.8	pKi	=	7.8	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	304	1	0	2	3.9	CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		15115524	115787	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	735	3	5	8	7.8	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N/C(S)=N/c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)cc2)C1	10.1021/jm00115a012
		CHEMBL321223	115787	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	735	3	5	8	7.8	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N/C(S)=N/c3ccc4c(c3)C(=O)OC43c4ccc(O)cc4Oc4cc(O)ccc43)cc2)C1	10.1021/jm00115a012
		6761	74574	19	None	-5	18	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		CHEMBL1909072	74574	19	None	-5	18	Human	7.8	pKi	=	7.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	nan
		44415701	86861	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	569	5	1	8	5.1	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		CHEMBL213110	86861	0	None	16	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	569	5	1	8	5.1	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		44415584	145472	0	None	50	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Br)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL377877	145472	0	None	50	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	523	2	1	5	5.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Br)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415601	148239	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	481	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL384269	148239	0	None	33	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	481	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		156018764	184574	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	2	1	3	3.8	COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2	10.1016/j.bmcl.2020.127305
		CHEMBL4643426	184574	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	2	1	3	3.8	COc1cc2c(cc1O)C(c1ccccc1Br)CN(C)CC2	10.1016/j.bmcl.2020.127305
		9844271	137460	1	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL368324	137460	1	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9884087	21409	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	21409	0	None	-4	2	Rat	7.8	pKi	=	7.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		9844271	137460	1	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL368324	137460	1	None	1	4	Rat	7.8	pKi	=	7.8	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9844271	137460	1	None	1	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL368324	137460	1	None	1	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	333	1	0	4	3.6	CN1CCN([C@@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		11716449	147993	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
		CHEMBL382850	147993	0	None	-2	4	Human	7.8	pKi	=	7.8	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	304	1	1	1	4.2	CCN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm050846j
		72699815	121974	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	349	3	1	4	3.9	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344467	121974	0	None	2	3	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	349	3	1	4	3.9	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		117773776	139237	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	3	1	5	3.9	Cc1cc(Sc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697599	139237	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	3	1	5	3.9	Cc1cc(Sc2ncccc2C(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		9817779	121210	0	None	-2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
		CHEMBL333246	121210	0	None	-2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm9706832
		45269168	202709	0	None	-10	4	Bovine	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	410	4	1	6	2.3	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(F)cc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL559399	202709	0	None	-10	4	Bovine	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	410	4	1	6	2.3	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccc(F)cc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		122189390	130023	0	None	-16	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	6	0	8	3.4	O=Cc1cnn2ccc(-n3cc(CCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		CHEMBL3613876	130023	0	None	-16	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	469	6	0	8	3.4	O=Cc1cnn2ccc(-n3cc(CCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		10973768	114337	0	None	-4073	10	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	563	6	1	8	4.4	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		CHEMBL318901	114337	0	None	-4073	10	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	563	6	1	8	4.4	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCn4c(=O)[nH]c5ccccc5c4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		681	8247	72	None	-23	38	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		940	8247	72	None	-23	38	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		947	8247	72	None	-23	38	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		CHEMBL59	8247	72	None	-23	38	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		DB00988	8247	72	None	-23	38	Bovine	5.8	pKi	=	5.8	Binding	Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1Binding Affinity was determined for its ability to displace the radioligand [3H]-SCH- 23390 from Bovine dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		10403608	84935	5	None	-1584	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL210405	84935	5	None	-1584	6	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		44412468	172709	0	None	-616	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL425057	172709	0	None	-616	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cnn(-c4ccccn4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		53317282	65372	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684131	65372	0	None	-173	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		24949534	196297	0	None	-2041	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
		CHEMBL514074	196297	0	None	-2041	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
		10403608	84935	5	None	-1584	6	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		CHEMBL210405	84935	5	None	-1584	6	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		145979897	173385	0	None	-158	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	480	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(I)cc1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4280542	173385	0	None	-158	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	480	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(I)cc1)CC2	10.1021/acsmedchemlett.8b00229
		57400556	76085	0	None	-2398	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	3.1	CCOCCOc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928134	76085	0	None	-2398	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	3.1	CCOCCOc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		10476504	40261	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1016/j.bmc.2017.04.036
		CHEMBL142020	40261	1	None	-64	7	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1016/j.bmc.2017.04.036
		10824155	64014	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	243	5	0	1	3.6	C#CC(C#C)=C1CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		CHEMBL165022	64014	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	243	5	0	1	3.6	C#CC(C#C)=C1CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		44436601	98718	0	None	-1584	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(C#Cc3ccccc3)cc2)CC1	10.1016/j.bmc.2007.08.038
		CHEMBL241424	98718	0	None	-1584	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(C#Cc3ccccc3)cc2)CC1	10.1016/j.bmc.2007.08.038
		15508238	11567	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	340	3	0	2	4.7	C(#Cc1cccn1C1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/s0960-894x(99)00540-5
		CHEMBL104092	11567	1	None	-4	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	340	3	0	2	4.7	C(#Cc1cccn1C1CCN(Cc2ccccc2)CC1)c1ccccc1	10.1016/s0960-894x(99)00540-5
		72544787	99905	0	None	-501	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	587	12	3	12	1.2	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4F)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443008	99905	0	None	-501	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	587	12	3	12	1.2	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOC4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4F)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		57400562	76093	0	None	-16	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(N2CCN(CCCCNC(=O)c3ccccc3)CC2)c(OC)c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928247	76093	0	None	-16	5	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(N2CCN(CCCCNC(=O)c3ccccc3)CC2)c(OC)c1	10.1016/j.bmc.2011.10.063
		71449034	85198	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL2111526	85198	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		44319361	212499	0	None	-7	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL82527	212499	0	None	-7	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
		10200496	90368	0	None	-295	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	391	6	1	3	3.6	O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm1013693
		CHEMBL2204343	90368	0	None	-295	5	Human	6.8	pKi	=	6.8	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	391	6	1	3	3.6	O=C(CCCN1CC[Si](O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm1013693
		11653679	187970	1	None	-24	11	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		CHEMBL476108	187970	1	None	-24	11	Human	6.8	pKi	=	6.8	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmc.2008.06.030
		9872676	84970	0	None	-4073	17	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
		CHEMBL210514	84970	0	None	-4073	17	Human	5.8	pKi	=	5.8	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	565	11	2	10	4.8	COc1nc(NCCCN2CCOCC2)nc(OC)c1NC(=O)c1ccc(Oc2cc3c(cc2C)CCC3(C)C)o1	10.1021/jm060012g
		11419055	136082	0	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	431	4	1	5	3.0	O=C1NCCN1CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL367087	136082	0	None	-12	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	431	4	1	5	3.0	O=C1NCCN1CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		10335576	127709	5	None	2	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3ccccc3Sc3ncccc32)CC1	10.1021/jm00030a011
		CHEMBL356076	127709	5	None	2	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3ccccc3Sc3ncccc32)CC1	10.1021/jm00030a011
		44278267	107040	0	None	-53	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	368	6	0	2	4.6	O=C1c2ccccc2CN1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL28884	107040	0	None	-53	3	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	368	6	0	2	4.6	O=C1c2ccccc2CN1CCCCN1CCC(c2ccc(Cl)cc2)C1	10.1016/s0960-894x(99)00201-2
		16090821	88608	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
		CHEMBL216439	88608	0	None	-52	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2c([nH]c3ccccc23)Cc2ccccc2CC1	10.1021/jm060213k
		46889212	14241	0	None	-263	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccncc1	10.1016/j.bmcl.2010.02.106
		CHEMBL1086958	14241	0	None	-263	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccncc1	10.1016/j.bmcl.2010.02.106
		13678338	107498	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.8	Oc1ccc(-c2c(O)c(O)c(Cl)c3c2CCNCC3)cc1	10.1021/jm00160a018
		CHEMBL292611	107498	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.8	Oc1ccc(-c2c(O)c(O)c(Cl)c3c2CCNCC3)cc1	10.1021/jm00160a018
		14198580	204741	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	301	3	0	2	4.1	COc1cc2c(cc1Cl)CCN(C)C2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL573412	204741	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	301	3	0	2	4.1	COc1cc2c(cc1Cl)CCN(C)C2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		154725766	183424	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4527244	183424	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4598000	183424	1	None	-1380	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		10546132	168034	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL41196	168034	0	None	9	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	1	3	4	4.8	Oc1cc2c(cc1O)[C@@H]1c3sc(C4CCCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
		44299852	204914	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	245	3	4	4	2.0	NCCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
		CHEMBL57470	204914	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	245	3	4	4	2.0	NCCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
		11346967	132205	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	3	3.4	O=C(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
		CHEMBL364586	132205	0	None	1	3	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	3	3.4	O=C(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
		11812345	23685	0	None	-5	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		CHEMBL125193	23685	0	None	-5	2	Rat	5.8	pKi	=	5.8	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		15711860	20630	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL1195937	20630	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL555619	20630	0	None	1	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		15069443	107748	0	None	3	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@H]21	10.1021/jm00128a038
		CHEMBL294215	107748	0	None	3	2	Rat	5.8	pKi	=	5.8	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@H]21	10.1021/jm00128a038
		154726922	183320	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4442936	183320	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4597157	183320	1	None	-19	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	468	12	0	6	5.6	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		15696481	86441	0	None	21	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL2115213	86441	0	None	21	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		11404156	73056	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	311	6	0	3	3.4	CC1CN(CCOc2ccccc2Cc2ccccc2)CCO1	10.1021/jm049720x
		CHEMBL184724	73056	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	311	6	0	3	3.4	CC1CN(CCOc2ccccc2Cc2ccccc2)CCO1	10.1021/jm049720x
		71722295	109244	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL2397381	109244	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL3040115	109244	0	None	-3	3	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	357	2	2	3	4.4	CN1CCc2ccc(Cc3ccccc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		145990190	173632	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4285528	173632	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	333	3	0	5	5.2	CC(C)(C)n1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		127035062	143229	0	None	-58	19	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		CHEMBL3735756	143229	0	None	-58	19	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membrane after 90 mins by scintillation counting method	ChEMBL	447	12	0	5	5.2	COc1ccc(CCN(CCCc2ccccc2)CCc2ccc3c(c2)OCO3)cc1OC	10.1039/C4MD00418C
		135398737	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		38	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		722	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		CHEMBL42	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		DB00363	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm981094e
		135398737	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		38	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		722	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		CHEMBL42	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		DB00363	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009890
		24800688	162497	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	309	3	1	3	3.9	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		CHEMBL405345	162497	0	None	-15	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	309	3	1	3	3.9	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		10498848	126830	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)cc2c1C(Cc1ccccc1O)N(C)CC2	10.1021/jm991034o
		CHEMBL350471	126830	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	361	3	1	3	3.9	COc1cc(Br)cc2c1C(Cc1ccccc1O)N(C)CC2	10.1021/jm991034o
		72708061	98974	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425372	98974	0	None	-1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		44582461	188696	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	350	5	0	4	2.3	O=C1c2ccccc2CCN1CCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477961	188696	0	None	4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	350	5	0	4	2.3	O=C1c2ccccc2CCN1CCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		70692655	82849	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057456	82849	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		71109804	94281	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	nan
		CHEMBL2334882	94281	0	None	12	3	Human	7.8	pKi	=	7.8	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	nan
		70692655	82849	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2057456	82849	0	None	8	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	371	4	2	6	2.6	COc1cc2c(cc1O)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		117772871	139258	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697621	139258	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		74223831	136231	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	2	6	2.1	Cc1c(-c2ccc(Oc3nccc4n[nH]cc34)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3671308	136231	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	349	3	2	6	2.1	Cc1c(-c2ccc(Oc3nccc4n[nH]cc34)cc2)n(C)c(=O)[nH]c1=O	nan
		15115518	15709	0	None	-380	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL109787	15709	0	None	-380	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		135398737	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		38	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		722	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		CHEMBL42	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		DB00363	7745	93	None	-83	90	Rat	6.8	pKi	=	6.8	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm960084f
		44447996	162282	0	None	-44	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		CHEMBL404137	162282	0	None	-44	2	Rat	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		145967572	171712	0	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	275	8	1	2	4.5	CCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4224763	171712	0	None	-33	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	275	8	1	2	4.5	CCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		122167	19013	13	None	-56	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards Dopamine receptor D1In vitro binding affinity towards Dopamine receptor D1	ChEMBL	263	5	2	3	3.1	CCCN(CCC)C1CCc2c(ccc(O)c2O)C1	10.1021/jm0307786
		CHEMBL11845	19013	13	None	-56	2	Rat	6.8	pKi	=	6.8	Binding	In vitro binding affinity towards Dopamine receptor D1In vitro binding affinity towards Dopamine receptor D1	ChEMBL	263	5	2	3	3.1	CCCN(CCC)C1CCc2c(ccc(O)c2O)C1	10.1021/jm0307786
		44340302	16524	0	None	-3	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL113471	16524	0	None	-3	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		25139329	193882	0	None	-11	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	514	10	0	4	7.6	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
		CHEMBL491466	193882	0	None	-11	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	514	10	0	4	7.6	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#Cc2ccccc2)CC1	10.1021/jm800895v
		71583848	94506	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		CHEMBL2336892	94506	0	None	-478	4	Bovine	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(N2CCN(Cc3cnn(-c4cc5ccc4CCc4ccc(cc4)CC5)c3)CC2)cc1	10.1016/j.bmc.2013.01.065
		137636460	162899	0	None	-120	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	7	1	6	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4063282	162899	0	None	-120	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	7	1	6	2.9	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
		122189387	130020	0	None	-45	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	417	7	0	8	2.7	COc1ccccc1N1CCN(CCCc2cn(-c3ccn4nccc4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
		CHEMBL3613873	130020	0	None	-45	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	417	7	0	8	2.7	COc1ccccc1N1CCN(CCCc2cn(-c3ccn4nccc4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
		44400594	140353	0	None	-85	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL371165	140353	0	None	-85	5	Pig	5.8	pKi	=	5.8	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		240	7731	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		2769	7731	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		44279790	7731	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		660	7731	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		CHEMBL1729	7731	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		CHEMBL560739	7731	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		DB00604	7731	43	None	-19	25	Rat	5.8	pKi	=	5.8	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	ChEMBL	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	10.1021/jm00086a019
		4420454	63033	6	None	-41	5	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		CHEMBL162762	63033	6	None	-41	5	Bovine	4.8	pKi	=	4.8	Binding	Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Binding Affinity was determined for decoupling of the ternary complex of Compound to Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		10454684	211584	0	None	-5623	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	418	3	0	4	3.3	Ic1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL7508	211584	0	None	-5623	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	418	3	0	4	3.3	Ic1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		44340186	16432	0	None	-45	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
		CHEMBL112831	16432	0	None	-45	4	Bovine	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCCN(Cc2ccccc2)C1	10.1016/s0960-894x(03)00678-4
		137640152	163532	0	None	-10715	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	631	15	3	10	4.0	CCCCn1cc(CCCOc2ccc(C(=O)NCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
		CHEMBL4070604	163532	0	None	-10715	5	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	631	15	3	10	4.0	CCCCn1cc(CCCOc2ccc(C(=O)NCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
		44437897	159832	0	None	-776	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	352	6	1	3	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)ccc1OC	10.1016/j.bmc.2007.07.017
		CHEMBL397592	159832	0	None	-776	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	352	6	1	3	2.8	C=CCN1CCC[C@H]1CNC(=O)c1cc(Br)ccc1OC	10.1016/j.bmc.2007.07.017
		90644059	118807	0	None	-22	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		CHEMBL3289643	118807	0	None	-22	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		25132869	110072	0	None	-269	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	400	3	2	2	5.5	O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
		CHEMBL3084503	110072	0	None	-269	6	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	400	3	2	2	5.5	O[C@]1(c2ccc(Cl)c(Cl)c2)C[C@@H]2CC[C@H](C1)N2Cc1c[nH]c2ccccc12	10.1021/jm800532x
		154705296	183173	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4444691	183173	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595970	183173	1	None	-39	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	6.9	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(C(F)(F)F)cc1	10.1021/acs.jmedchem.9b01835
		154726793	183012	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4590966	183012	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4594692	183012	1	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	454	11	0	6	5.2	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		45481839	204873	0	None	-22	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	4	1	2	3.7	CCCCC1NCCc2cc(Cl)c(OC)cc21	10.1016/j.bmc.2009.05.079
		CHEMBL574418	204873	0	None	-22	2	Rat	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	253	4	1	2	3.7	CCCCC1NCCc2cc(Cl)c(OC)cc21	10.1016/j.bmc.2009.05.079
		46227284	206494	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.5	COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2	10.1016/j.bmc.2009.08.028
		CHEMBL593394	206494	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.5	COc1ccc2c(c1)CCN(C)Cc1ccccc1CC2	10.1016/j.bmc.2009.08.028
		11351639	67298	0	None	-93	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		CHEMBL175734	67298	0	None	-93	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	459	6	1	4	5.3	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm900095y
		44299993	108699	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL301003	108699	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		72708058	98970	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425368	98970	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		25256817	188205	0	None	-169	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	445	6	0	3	5.0	O=C1c2ccccc2CCCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476394	188205	0	None	-169	4	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	445	6	0	3	5.0	O=C1c2ccccc2CCCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		44582489	196579	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	3.9	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL516270	196579	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	417	5	0	3	3.9	O=C1c2ccccc2CCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
		14198596	108420	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL299056	108420	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		145969667	171744	0	None	-30	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4225278	171744	0	None	-30	6	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		14198596	108420	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00118a012
		CHEMBL299056	108420	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00118a012
		13678327	208833	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	329	8	3	4	4.1	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
		CHEMBL60861	208833	0	None	1	2	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	329	8	3	4	4.1	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccc(O)cc1	10.1021/jm00160a018
		11151583	136241	0	None	-2	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	327	2	1	5	2.6	CN1CCN(C2=Cn3c(CO)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
		CHEMBL367180	136241	0	None	-2	2	Rat	5.8	pKi	=	5.8	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	327	2	1	5	2.6	CN1CCN(C2=Cn3c(CO)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
		44415738	86669	0	None	22	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	1	1	4	6.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C(=O)Nc3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212384	86669	0	None	22	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	513	1	1	4	6.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(C(=O)Nc3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		135995891	209739	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	413	4	1	5	4.1	Oc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL62996	209739	0	None	-30	4	Bovine	4.8	pKi	=	4.8	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	413	4	1	5	4.1	Oc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		154726046	183090	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4442408	183090	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595266	183090	1	None	-446	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		44582678	188353	0	None	-12	10	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL476839	188353	0	None	-12	10	Human	5.8	pKi	=	5.8	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	401	9	1	4	4.3	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		15696482	86334	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL2114209	86334	0	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	223	2	3	4	1.4	CC[C@H]1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		14198596	108420	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL299056	108420	0	None	2	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		14198600	108668	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL300778	108668	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		14198601	107678	1	None	1	4	Human	6.8	pKi	=	6.8	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
		CHEMBL293828	107678	1	None	1	4	Human	6.8	pKi	=	6.8	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
		44582115	188454	0	None	-154	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	6	0	3	4.6	O=C1c2ccccc2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477646	188454	0	None	-154	3	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	6	0	3	4.6	O=C1c2ccccc2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		180	7189	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		200	7189	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		2160	7189	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		CHEMBL629	7189	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		DB00321	7189	56	None	-109	40	Human	6.8	pKi	=	6.8	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	nan
		130907	201462	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL53294	201462	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		1704	10295	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		4331799	10295	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		CHEMBL1334465	10295	85	None	-57	5	Human	5.8	pKi	=	5.8	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	3	2	3	4.5	O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C	10.1016/j.bmcl.2013.06.057
		23656545	153548	0	None	-83	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	3	3.5	COc1cc2c3c(c1)-c1c(ccc(C)c1O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2007.05.057
		CHEMBL392447	153548	0	None	-83	3	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	1	3	3.5	COc1cc2c3c(c1)-c1c(ccc(C)c1O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2007.05.057
		14198600	108668	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL300778	108668	2	None	3	2	Rat	6.8	pKi	=	6.8	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		1212	8443	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		204	8443	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		3372	8443	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		CHEMBL726	8443	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		DB00623	8443	50	None	-51	65	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1016/j.bmcl.2008.09.012
		14198601	107678	1	None	-1	4	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
		CHEMBL293828	107678	1	None	-1	4	Rat	6.8	pKi	=	6.8	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
		13678309	201705	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	255	1	3	3	2.5	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2	10.1021/jm00160a018
		CHEMBL54168	201705	1	None	-	1	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	255	1	3	3	2.5	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2	10.1021/jm00160a018
		3036864	209533	19	None	-26	27	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	209533	19	None	-26	27	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	209533	19	None	-26	27	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	209533	19	None	-26	27	Bovine	7.8	pKi	=	7.8	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid glandAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of calf parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		10084583	111555	4	None	-33	6	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
		CHEMBL310867	111555	4	None	-33	6	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	271	5	0	3	3.3	CCCN(CCC)[C@H]1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
		5281878	8441	35	None	-34	16	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		5281881	8441	35	None	-34	16	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		948	8441	35	None	-34	16	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		968	8441	35	None	-34	16	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		CHEMBL42055	8441	35	None	-34	16	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		CHEMBL54661	8441	35	None	-34	16	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		DB00875	8441	35	None	-34	16	Bovine	7.8	pKi	=	7.8	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm950759z
		44578927	196441	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	335	4	0	3	4.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)CC)c1-3	10.1016/j.bmc.2008.08.056
		CHEMBL515187	196441	0	None	6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	335	4	0	3	4.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)CC)c1-3	10.1016/j.bmc.2008.08.056
		11976	7707	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		667467	7707	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		CHEMBL908	7707	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		DB01239	7707	59	None	-12	24	Human	7.8	pKi	=	7.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	10.1016/j.bmcl.2008.09.012
		10684714	107086	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115372	107086	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL289283	107086	0	None	13	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		9796958	153356	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115374	153356	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL39230	153356	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL544814	153356	0	None	25	4	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		10684715	167419	0	None	11	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL41132	167419	0	None	11	2	Rat	7.8	pKi	=	7.8	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		11089340	19660	0	None	-5	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	2	0	4	4.0	CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL118889	19660	0	None	-5	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	2	0	4	4.0	CCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		17756101	105360	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1021/jm070388+
		CHEMBL276778	105360	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1021/jm070388+
		86764103	139215	13	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697578	139215	13	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		10457445	109970	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	470	14	4	6	5.0	CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		CHEMBL308295	109970	0	None	-5	3	Rat	7.7	pKi	=	7.7	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	470	14	4	6	5.0	CCCN(CCCCCCN1CCC[C@@H]1Cc1ccc(O)c(O)c1)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		10656804	123337	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL336366	123337	0	None	-	1	Rat	7.7	pKi	=	7.7	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2cc(O)ccc2[C@H]1c1ccccc1	10.1021/jm960318v
		1621	9207	17	None	-112	44	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		17	9207	17	None	-112	44	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		5761	9207	17	None	-112	44	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		CHEMBL263881	9207	17	None	-112	44	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		DB04829	9207	17	None	-112	44	Mouse	6.8	pKi	=	6.8	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	ChEMBL	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm020153s
		44276414	104404	0	None	12	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL27101	104404	0	None	12	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3ccc(F)nc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		45482169	204617	0	None	-6	4	Pig	6.8	pKi	=	6.8	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	559	12	1	8	4.5	O=C(CCCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2009.06.041
		CHEMBL572379	204617	0	None	-6	4	Pig	6.8	pKi	=	6.8	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	559	12	1	8	4.5	O=C(CCCc1cn(-c2ccc([N+](=O)[O-])cc2)nn1)NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmc.2009.06.041
		135398737	7745	93	None	-44	90	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		38	7745	93	None	-44	90	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		722	7745	93	None	-44	90	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		CHEMBL42	7745	93	None	-44	90	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		DB00363	7745	93	None	-44	90	Human	6.8	pKi	=	6.8	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9601720
		44209472	76947	2	None	-97	11	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940420	76947	2	None	-97	11	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	315	6	0	4	2.8	Fc1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		90644228	118563	0	None	-29	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287402	118563	0	None	-29	5	Human	6.8	pKi	=	6.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		11092112	214407	0	None	-3162	9	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	485	6	0	6	4.9	O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
		CHEMBL95175	214407	0	None	-3162	9	Rat	5.8	pKi	=	5.8	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	485	6	0	6	4.9	O=C1OCCN1CCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
		44403232	77851	0	None	-112	5	Pig	5.8	pKi	=	5.8	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	459	8	1	4	4.0	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
		CHEMBL195247	77851	0	None	-112	5	Pig	5.8	pKi	=	5.8	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	459	8	1	4	4.0	O=S(=O)(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
		44436610	98724	0	None	-234	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL241436	98724	0	None	-234	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
		130907	201462	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL53294	201462	5	None	-3311	4	Rat	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		52937680	67947	0	None	-3235	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	466	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1Cc2cccn3ncc(c23)C1	10.1021/jm101639t
		CHEMBL1765632	67947	0	None	-3235	4	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	466	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1Cc2cccn3ncc(c23)C1	10.1021/jm101639t
		137659990	166009	0	None	-3019	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccn2ncc(/C=N\O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4098859	166009	0	None	-3019	5	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccn2ncc(/C=N\O)c2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		57393627	76082	0	None	-199	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1101	42	2	17	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928131	76082	0	None	-199	5	Pig	5.8	pKi	=	5.8	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1101	42	2	17	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		11077918	213373	0	None	-13	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1	10.1021/jm015522j
		CHEMBL88937	213373	0	None	-13	4	Bovine	4.8	pKi	=	4.8	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccc4ccnn34)CC2)cc1	10.1021/jm015522j
		46869265	23029	0	None	-4	7	Human	4.8	pKi	=	4.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
		CHEMBL1224527	23029	0	None	-4	7	Human	4.8	pKi	=	4.8	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2010.07.052
		73353534	97833	0	None	-4168	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
		CHEMBL2397477	97833	0	None	-4168	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	549	18	1	7	5.4	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cnn(CCCC)n3)c(OC)c2)CC1	10.1021/jm400520c
		71733932	97827	0	None	-24547	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
		CHEMBL2397389	97827	0	None	-24547	6	Human	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm501889t
		23642427	98574	0	None	-38904	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	430	7	1	4	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		CHEMBL241169	98574	0	None	-38904	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	430	7	1	4	2.7	C=CCN1CCC[C@H]1CNC(=O)c1cc(I)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		24824061	104673	0	None	-25	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
		CHEMBL272396	104673	0	None	-25	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
		10021692	153160	19	None	-23442	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	364	10	1	4	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		CHEMBL392158	153160	19	None	-23442	4	Pig	4.8	pKi	=	4.8	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	364	10	1	4	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)cc(OC)c1OC	10.1016/j.bmc.2007.07.017
		132060743	169015	0	None	-7	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		CHEMBL4163428	169015	0	None	-7	13	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells after 90 mins by microbeta scintillation counting method	ChEMBL	351	3	0	4	3.1	CN1CCN(c2ccc3c(c2)CN(C(=O)OCc2ccccc2)C3)CC1	10.1016/j.ejmech.2018.02.024
		145969667	171744	0	None	-30	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4225278	171744	0	None	-30	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	289	9	1	2	4.9	CCCCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		228	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		33	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		6005	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		CHEMBL53	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		DB00714	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm991034o
		11559090	162340	0	None	-60	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	335	1	2	3	3.8	CC1(c2cccc(O)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		CHEMBL404352	162340	0	None	-60	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH-23390 from human cloned dopamine D1 receptor	ChEMBL	335	1	2	3	3.8	CC1(c2cccc(O)c2)C(=O)Nc2cc(Cl)cc(Cl)c2C1=O	10.1016/j.bmcl.2007.11.045
		44567689	190588	0	None	-7	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	309	3	1	3	3.9	CCCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
		CHEMBL480525	190588	0	None	-7	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	309	3	1	3	3.9	CCCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
		145979855	173307	0	None	-83	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	405	7	2	5	3.5	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccnc3ccccc13)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4279136	173307	0	None	-83	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	405	7	2	5	3.5	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccnc3ccccc13)CC2	10.1021/acsmedchemlett.8b00229
		72708058	98970	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425368	98970	0	None	1	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	329	2	0	3	4.0	COc1ccc2c(c1)CC1c3cc(OC)c(Cl)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		70690497	82838	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
		CHEMBL2057438	82838	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.bmc.2012.05.057
		70690497	82838	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL2057438	82838	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	1	6	2.6	COc1cc(OC)c2c(c1CO)C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		681	8247	72	None	-154	38	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		940	8247	72	None	-154	38	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		947	8247	72	None	-154	38	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		CHEMBL59	8247	72	None	-154	38	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		DB00988	8247	72	None	-154	38	Human	4.7	pKi	=	4.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9800292
		13903144	106862	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
		CHEMBL1743798	106862	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
		CHEMBL287332	106862	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	285	1	0	1	4.2	Fc1ccc([C@@H]2CN3CCC[C@@H]3c3cc(F)ccc32)cc1	10.1021/jm00391a028
		46227317	206942	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.4	COc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
		CHEMBL596448	206942	0	None	1	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.4	COc1ccc2c(c1)CCN1Cc3ccccc3CC21	10.1016/j.bmc.2009.08.028
		45379377	14229	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21	10.1021/jm901291r
		CHEMBL1086790	14229	0	None	-1	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3cccc4[nH]cc(c34)C21	10.1021/jm901291r
		10107367	109211	1	None	-7	4	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL303993	109211	1	None	-7	4	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		11777127	32582	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL135318	32582	0	None	1	2	Rat	6.7	pKi	=	6.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		117773975	139212	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	367	4	1	6	2.9	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1C	nan
		CHEMBL3697575	139212	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	367	4	1	6	2.9	COc1cc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)ncc1C	nan
		4011	89183	49	None	-64	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		CHEMBL21731	89183	49	None	-64	24	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	nan
		71722293	109252	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
		CHEMBL2397380	109252	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
		CHEMBL3040164	109252	0	None	-8	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	281	0	2	3	3.2	Cc1ccc2c3c1-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2013.05.014
		135398737	7745	93	None	-44	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		38	7745	93	None	-44	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		722	7745	93	None	-44	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		CHEMBL42	7745	93	None	-44	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		DB00363	7745	93	None	-44	90	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1039/C5MD00258C
		60165416	82071	0	None	-478	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL2037431	82071	0	None	-478	8	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	0	4	5.1	Clc1ccc(N2CCN(CCCCc3nc4ccccc4s3)CC2)cc1	10.1016/j.bmc.2014.04.026
		44439944	158648	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2	10.1016/j.bmcl.2006.11.093
		CHEMBL396561	158648	0	None	1	4	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	320	1	1	2	3.8	COc1ccc2c(c1)CCN(C)CCc1c([nH]c3ccccc13)C2	10.1016/j.bmcl.2006.11.093
		49782600	24225	0	None	-4	5	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	1	3	4.4	Cc1ccc(C)c(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
		CHEMBL1257689	24225	0	None	-4	5	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	1	3	4.4	Cc1ccc(C)c(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
		127031397	145508	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	397	7	1	5	4.6	CCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3780140	145508	0	None	5	3	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	397	7	1	5	4.6	CCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		44401106	131105	0	None	-29	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL363581	131105	0	None	-29	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		9796255	135826	0	None	-17	7	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm0309811
		CHEMBL367045	135826	0	None	-17	7	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm0309811
		9796255	135826	0	None	-17	7	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm049629t
		CHEMBL367045	135826	0	None	-17	7	Rat	7.7	pKi	=	7.7	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	297	1	0	4	3.2	CN1CCN(C2=Cn3cccc3Sc3ccccc32)CC1	10.1021/jm049629t
		10894826	17258	0	None	-3	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL116542	17258	0	None	-3	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		9884087	21409	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	21409	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		71733935	97758	0	None	-457	6	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
		CHEMBL2396663	97758	0	None	-457	6	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
		1242	10385	27	None	-5	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
		935	10385	27	None	-5	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL286080	10385	27	None	-5	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2008.09.049
		25110707	19379	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL1186974	19379	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL485036	19379	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	365	2	3	3	4.7	Oc1cc2c(c(-c3ccc(Cl)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		10594054	38187	1	None	-562	4	Bovine	5.7	pKi	=	5.7	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2cc(CN3CCN(c4ccccc4Cl)CC3)[nH]c2c1	10.1021/jm0009989
		CHEMBL140258	38187	1	None	-562	4	Bovine	5.7	pKi	=	5.7	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2cc(CN3CCN(c4ccccc4Cl)CC3)[nH]c2c1	10.1021/jm0009989
		14198600	108668	2	None	3	2	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL300778	108668	2	None	3	2	Rat	5.7	pKi	=	5.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	301	3	1	2	4.4	CCCN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		54583898	68385	0	None	-3801	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	417	7	0	4	3.3	C#Cc1ccc2c(c1)CCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
		CHEMBL1771114	68385	0	None	-3801	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	417	7	0	4	3.3	C#Cc1ccc2c(c1)CCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
		44412482	84934	0	None	-4365	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL210404	84934	0	None	-4365	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cnn(-c3ccccn3)c2)CC1	10.1016/j.bmcl.2006.02.075
		17475863	175563	3	None	-660	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL437490	175563	3	None	-660	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		53317208	65329	0	None	-234	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	634	14	0	8	6.4	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCn2cc(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684029	65329	0	None	-234	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	634	14	0	8	6.4	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCn2cc(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		24854106	167840	1	None	-95	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
		CHEMBL411663	167840	1	None	-95	8	Human	5.7	pKi	=	5.7	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	367	6	1	3	3.9	O=C1Nc2ccc(F)cc2C1CCCCN1CCN(c2ccccc2)CC1	10.1021/jm070279v
		10960333	213763	0	None	-2	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	398	5	0	6	3.5	CCOC(=O)c1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
		CHEMBL91362	213763	0	None	-2	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	398	5	0	6	3.5	CCOC(=O)c1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
		44339953	116477	0	None	-707	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
		CHEMBL322802	116477	0	None	-707	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
		21559988	120204	3	None	-30	4	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	389	5	1	3	4.0	O=C(CCC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318852	120204	3	None	-30	4	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	389	5	1	3	4.0	O=C(CCC(=O)N1CCC(O)(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2014.06.079
		9797495	75779	0	None	-17378	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	328	3	0	4	2.9	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cc1	10.1021/jm200762g
		CHEMBL1923292	75779	0	None	-17378	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	328	3	0	4	2.9	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cc1	10.1021/jm200762g
		44381279	65513	0	None	-41	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
		CHEMBL168571	65513	0	None	-41	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
		44415837	146317	0	None	5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	3	1	5	5.9	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL379593	146317	0	None	5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	3	1	5	5.9	CC(C)N1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		154724369	183468	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4584372	183468	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4598389	183468	1	None	-51	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	484	12	0	6	6.1	CCCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		681	8247	72	None	-154	38	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		940	8247	72	None	-154	38	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		947	8247	72	None	-154	38	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		CHEMBL59	8247	72	None	-154	38	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		DB00988	8247	72	None	-154	38	Human	6.7	pKi	=	6.7	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00170a025
		6603800	10321	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		956	10321	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		CHEMBL63321	10321	11	None	1	2	Human	6.7	pKi	=	6.7	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	287	1	1	2	3.7	CN1CCc2c([C@@H](C1)c1ccccc1)cc(c(c2)Cl)O	10.1021/jm00081a010
		5281148	210688	50	None	5	4	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	260	8	2	2	2.8	C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC	10.1016/j.bmc.2007.12.021
		CHEMBL69018	210688	50	None	5	4	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from rat HA-tagged D1 dopamine receptor expressed in CHO cells	ChEMBL	260	8	2	2	2.8	C=C[C@@H](O)C#CC#C[C@@H](O)/C=C\CCCCCCC	10.1016/j.bmc.2007.12.021
		14198585	107578	1	None	1	4	Rat	4.7	pKi	=	4.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL293158	107578	1	None	1	4	Rat	4.7	pKi	=	4.7	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		44582705	193775	0	None	-12	13	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL490632	193775	0	None	-12	13	Human	5.7	pKi	=	5.7	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	399	9	0	4	4.5	COc1c(OCCF)cccc1C(=O)C1CCN(CCc2ccc(C)cc2)CC1	10.1016/j.bmc.2009.03.021
		2351	10059	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		2820	10059	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		5035	10059	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		CHEMBL81	10059	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		DB00481	10059	64	None	-16	21	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	nan
		12488	8438	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		941361	8438	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		CHEMBL30008	8438	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		DB04841	8438	56	None	-19	23	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	nan
		10338282	41461	1	None	-2	6	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
		CHEMBL143022	41461	1	None	-2	6	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	355	4	0	4	3.8	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2occc21	10.1021/jm0009890
		13678325	108697	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	313	8	2	3	4.4	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
		CHEMBL300995	108697	0	None	-	1	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	313	8	2	3	4.4	CCCN(CCC)CCc1ccc(O)c(O)c1-c1ccccc1	10.1021/jm00160a018
		6937303	209986	7	None	-43	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	335	4	0	4	4.1	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)cs2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL64376	209986	7	None	-43	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	335	4	0	4	4.1	c1ccc(-c2nc(CN3CCN(c4ccccc4)CC3)cs2)cc1	10.1016/s0960-894x(00)00405-4
		44278364	106196	0	None	-169	3	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	334	6	0	2	3.9	O=C1c2ccccc2CN1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL282822	106196	0	None	-169	3	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	334	6	0	2	3.9	O=C1c2ccccc2CN1CCCCN1CCC(c2ccccc2)C1	10.1016/s0960-894x(99)00201-2
		68950	134317	12	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	8	0	2	4.0	CCN(CC)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		CHEMBL366265	134317	12	None	1	3	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	8	0	2	4.0	CCN(CC)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		191	7191	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		201	7191	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		2170	7191	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		CHEMBL1113	7191	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		DB00543	7191	98	None	-26	29	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	nan
		242	7258	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		34	7258	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		60795	7258	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		CHEMBL1112	7258	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		DB01238	7258	124	None	-74	51	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm800689g
		46931072	208824	1	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL608530	208824	1	None	-8	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		15711870	19728	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL1189332	19728	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL538520	19728	0	None	1	3	Goldfish	6.7	pKi	=	6.7	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		164610779	191862	0	None	-81	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	558	7	2	5	4.5	COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccc(I)c(OC)c1)CC2	10.1016/j.bmcl.2021.128047
		CHEMBL4855891	191862	0	None	-81	3	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	558	7	2	5	4.5	COc1cc2c(cc1O)CN(Cc1ccccc1CNC(=O)c1ccc(I)c(OC)c1)CC2	10.1016/j.bmcl.2021.128047
		10046389	68190	0	None	-1122	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
		CHEMBL177031	68190	0	None	-1122	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
		15136	114887	2	None	-154	2	Rat	5.7	pKi	=	5.7	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		CHEMBL319557	114887	2	None	-154	2	Rat	5.7	pKi	=	5.7	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		44432812	94343	0	None	-5	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	3	2	3	3.4	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		CHEMBL233567	94343	0	None	-5	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	3	2	3	3.4	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(CO)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		154703541	183078	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4541924	183078	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595195	183078	1	None	-85	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	464	11	1	3	6.1	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		11186895	94282	25	None	-5	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmcl.2017.01.090
		CHEMBL2334885	94282	25	None	-5	4	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmcl.2017.01.090
		1353	8692	93	None	-74	85	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		3559	8692	93	None	-74	85	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		86	8692	93	None	-74	85	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		CHEMBL54	8692	93	None	-74	85	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		DB00502	8692	93	None	-74	85	Rat	6.7	pKi	=	6.7	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0009890
		46231589	208080	0	None	999	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNc3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
		CHEMBL604108	208080	0	None	999	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccc(CNc3ccccc3)cc2)C1	10.1016/j.bmcl.2009.12.100
		37459	7533	13	None	-10	24	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
		62	7533	13	None	-10	24	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
		CHEMBL8514	7533	13	None	-10	24	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127053
		142405827	186644	0	None	-14	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	421	2	1	4	6.1	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(OC(F)(F)F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4745489	186644	0	None	-14	3	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	421	2	1	4	6.1	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccc(OC(F)(F)F)cc32)CCN1C	10.1016/j.bmcl.2020.127563
		142405818	187638	0	None	34	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	367	2	1	4	5.2	COc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4757297	187638	0	None	34	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	367	2	1	4	5.2	COc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		15937728	26767	0	None	288	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C(C2C=CCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL130328	26767	0	None	288	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C(C2C=CCCC2)C1	10.1016/S0960-894X(00)80155-9
		11623343	147620	1	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		CHEMBL381936	147620	1	None	-2	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	283	0	2	3	2.7	CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1	10.1021/jm051237e
		44415702	146677	0	None	87	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	2	1	5	5.4	Cc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL379942	146677	0	None	87	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	2	1	5	5.4	Cc1ccccc1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		16665071	100176	0	None	-8	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	334	1	0	3	3.8	COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL245764	100176	0	None	-8	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	334	1	0	3	3.8	COc1ccc2c(c1)c1c(n2C)Cc2ccccc2CCN(C)CC1	10.1016/j.bmcl.2006.11.093
		10004036	102004	0	None	33	2	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		CHEMBL256075	102004	0	None	33	2	Rat	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	453	2	2	5	3.5	COc1cc2c(cc1O)C[C@H]1c3c(c(I)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		71563084	94346	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2335736	94346	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	409	3	2	5	3.9	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(OC(F)(F)F)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		46231847	207353	0	None	3	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	343	1	2	3	3.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL599116	207353	0	None	3	4	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	343	1	2	3	3.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(CO)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		6603950	210103	9	None	-6	8	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL64875	210103	9	None	-6	8	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		6603950	210103	9	None	-6	8	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL64875	210103	9	None	-6	8	Rat	8.7	pKi	=	8.7	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		16090814	88356	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL216258	88356	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2008.04.081
		6603950	210103	9	None	-6	8	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL64875	210103	9	None	-6	8	Rat	8.7	pKi	=	8.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN([C@@H]2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		10935201	27656	0	None	758	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.1	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL131054	27656	0	None	758	2	Rat	8.7	pKi	=	8.7	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	291	1	1	2	4.1	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCCC2)C1	10.1016/S0960-894X(00)80155-9
		16090814	88356	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
		CHEMBL216258	88356	0	None	-1	5	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cellsDisplacement of [3H]SCH 23390 from human D1 dopamine receptor expressed in HEK293 cells	ChEMBL	304	0	1	1	4.2	CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/jm060213k
		134151764	159923	0	None	31	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	433	4	2	5	4.3	CCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3976659	159923	0	None	31	3	Human	8.7	pKi	=	8.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	433	4	2	5	4.3	CCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		1238	209953	24	None	-5	16	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL64249	209953	24	None	-5	16	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		15115523	115646	1	None	691	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	346	1	2	3	3.4	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N)cc2)C1	10.1021/jm00115a012
		CHEMBL321042	115646	1	None	691	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	346	1	2	3	3.4	CN1CCc2cc(Br)c(O)cc2C(c2ccc(N)cc2)C1	10.1021/jm00115a012
		11315462	207245	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)C4CC4)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL598516	207245	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(NC(=O)C4CC4)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		46231833	207690	0	None	218	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	384	2	2	3	4.3	CCC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL601634	207690	0	None	218	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	384	2	2	3	4.3	CCC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		142405825	186618	0	None	-24	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4745124	186618	0	None	-24	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.5	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		134135947	151167	0	None	46	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	5	2	5	4.7	CCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3905947	151167	0	None	46	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	5	2	5	4.7	CCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		37459	7533	13	None	-10	24	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
		62	7533	13	None	-10	24	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
		CHEMBL8514	7533	13	None	-10	24	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2016.03.037
		46231782	207282	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	371	1	1	4	3.8	COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		CHEMBL598730	207282	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	371	1	1	4	3.8	COC(=O)c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		46232064	208127	0	None	707	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	473	2	1	3	6.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(OC(F)(F)F)c4)c3CC[C@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604383	208127	0	None	707	2	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	473	2	1	3	6.5	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(-c4cccc(OC(F)(F)F)c4)c3CC[C@H]21	10.1016/j.bmcl.2009.12.094
		1238	209953	24	None	-5	16	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL64249	209953	24	None	-5	16	Rat	8.6	pKi	=	8.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		10662054	91187	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2114444	91187	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2219803	91187	0	None	151	2	Rat	8.6	pKi	=	8.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		146266	107474	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
		CHEMBL292418	107474	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
		CHEMBL540857	107474	8	None	2	4	Rat	8.6	pKi	=	8.6	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00118a012
		46231772	208088	0	None	371	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL604132	208088	0	None	371	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	399	2	3	3	4.1	CCNC(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		162676091	190103	0	None	512	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	401	2	1	4	5.7	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(OC(F)(F)F)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4797375	190103	0	None	512	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	401	2	1	4	5.7	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(OC(F)(F)F)ccc1N2	10.1016/j.bmcl.2020.127563
		75202022	177589	2	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		CHEMBL4453318	177589	2	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	363	3	1	6	3.3	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		10537185	32457	0	None	-12	2	Rat	8.6	pKi	=	8.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135224	32457	0	None	-12	2	Rat	8.6	pKi	=	8.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		44415672	86949	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213492	86949	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(F)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		70690500	82848	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.12.016
		CHEMBL2057455	82848	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.12.016
		70690500	82848	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057455	82848	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		70690500	82848	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		CHEMBL2057455	82848	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		44415689	145887	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL378669	145887	0	None	-2	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	494	2	2	6	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		46231846	208118	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	341	1	1	3	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604316	208118	0	None	1	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	341	1	1	3	3.8	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		17755867	92884	1	None	-1	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL231070	92884	1	None	-1	6	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		9993922	66740	0	None	3	2	Rat	8.6	pKi	=	8.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	282	1	0	2	3.5	CN1CCc2cccc3c2C(C1)CN3c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
		CHEMBL173315	66740	0	None	3	2	Rat	8.6	pKi	=	8.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	282	1	0	2	3.5	CN1CCc2cccc3c2C(C1)CN3c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
		46231768	206259	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL591685	206259	0	None	2	3	Human	8.6	pKi	=	8.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		11439190	208084	0	None	31	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	338	0	1	3	3.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL604127	208084	0	None	31	4	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	338	0	1	3	3.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C#N)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		37461	23906	14	None	-3	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1016/j.bmcl.2021.128047
		CHEMBL1255588	23906	14	None	-3	8	Human	8.6	pKi	=	8.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1016/j.bmcl.2021.128047
		44268688	173354	0	None	37	2	Rat	8.5	pKi	=	8.5	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
		CHEMBL427996	173354	0	None	37	2	Rat	8.5	pKi	=	8.5	Binding	Compound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brainCompound was evaluated for affinity towards dopamine D1-like receptor in homogenate of caudate putamen tissue from rat brain	ChEMBL		None	None	None		None	10.1016/s0960-894x(00)00185-2
		4350931	176092	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
		CHEMBL441618	176092	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
		4350931	176092	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
		CHEMBL441618	176092	44	None	-63	7	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1	10.1021/acs.jmedchem.1c01327
		1353	8692	93	None	-74	85	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		3559	8692	93	None	-74	85	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		86	8692	93	None	-74	85	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		CHEMBL54	8692	93	None	-74	85	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		DB00502	8692	93	None	-74	85	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/s0960-894x(98)00138-3
		44331310	114143	1	None	25	3	Human	7.7	pKi	=	7.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9800292
		CHEMBL317741	114143	1	None	25	3	Human	7.7	pKi	=	7.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(cc(O)c(O)c2Cl)[C@@H](c2ccccc2)C1	10.1021/jm9800292
		44415649	145202	0	None	162	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		CHEMBL377420	145202	0	None	162	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		135398745	9688	112	None	-23	65	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
		47	9688	112	None	-23	65	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
		CHEMBL715	9688	112	None	-23	65	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
		DB00334	9688	112	None	-23	65	Rat	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm100294b
		10894826	17258	0	None	-3	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		CHEMBL116542	17258	0	None	-3	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	407	3	1	5	3.1	OCCN1CCN(C2Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm010982y
		10519435	178248	0	None	87	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL446350	178248	0	None	87	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	1	3	4	3.8	CC(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		10015045	20424	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00004a011
		CHEMBL119455	20424	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00004a011
		10015045	20424	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960188q
		CHEMBL119455	20424	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960188q
		10015045	20424	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
		CHEMBL119455	20424	1	None	-2	6	Rat	7.7	pKi	=	7.7	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm960189i
		16103	211417	47	None	-2	4	Rat	6.7	pKi	=	6.7	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00043a008
		CHEMBL73538	211417	47	None	-2	4	Rat	6.7	pKi	=	6.7	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	292	0	1	4	3.1	CN1CCN(C2=Nc3ccccc3Nc3ccccc32)CC1	10.1021/jm00043a008
		155515982	176789	0	None	-794	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4442460	176789	0	None	-794	17	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	473	10	2	5	4.1	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccccc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		56833464	75171	0	None	-99	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1138	38	2	16	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		CHEMBL1916720	75171	0	None	-99	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1138	38	2	16	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		14378574	115364	0	None	-7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
		CHEMBL320397	115364	0	None	-7	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(O)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
		57390116	76073	0	None	-323	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928122	76073	0	None	-323	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
		118709175	120200	0	None	-107	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	474	10	0	5	4.9	CN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318848	120200	0	None	-107	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	474	10	0	5	4.9	CN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		10378194	204544	0	None	-338	6	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	265	3	1	2	2.3	C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
		CHEMBL57176	204544	0	None	-338	6	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	265	3	1	2	2.3	C#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
		10862425	123411	0	None	-467	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccnn3c2)CC1	10.1021/jm025558r
		CHEMBL336930	123411	0	None	-467	5	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc3ccnn3c2)CC1	10.1021/jm025558r
		10613676	20628	0	None	-165	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1021/jm060959i
		CHEMBL119593	20628	0	None	-165	4	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1021/jm060959i
		10092819	23545	0	None	-1412	11	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
		CHEMBL124444	23545	0	None	-1412	11	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
		52947756	23942	0	None	-478	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	567	6	0	2	8.3	O=C(CCCN1CCC(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1256170	23942	0	None	-478	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	567	6	0	2	8.3	O=C(CCCN1CCC(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		44319368	112841	0	None	-7	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
		CHEMBL313320	112841	0	None	-7	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
		44319369	212598	0	None	-11	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
		CHEMBL83306	212598	0	None	-11	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
		44380802	168470	0	None	-131	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL413343	168470	0	None	-131	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	401	7	2	4	3.9	CNc1cc(OC)c(C(=O)NC[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(99)00086-4
		6469693	86730	17	None	-7079	6	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	322	4	0	5	2.7	COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1	10.1021/jm060166w
		CHEMBL212631	86730	17	None	-7079	6	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	322	4	0	5	2.7	COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1	10.1021/jm060166w
		44319369	212598	0	None	-11	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
		CHEMBL83306	212598	0	None	-11	4	Bovine	4.7	pKi	=	4.7	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	335	4	0	4	3.0	C[C@@H]1OC(c2ccccc2)=N[C@H]1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(01)00484-x
		2247	7293	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		249	7293	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		2603	7293	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		CHEMBL296419	7293	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		DB00637	7293	81	None	-61	42	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	nan
		24949857	188546	0	None	-7413	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
		CHEMBL477765	188546	0	None	-7413	3	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	10.1021/jm800176x
		53318500	65324	0	None	-57	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	630	10	0	7	6.9	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684024	65324	0	None	-57	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	630	10	0	7	6.9	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		2993172	133945	4	None	1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	0	3	3.0	c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1	10.1021/jm049720x
		CHEMBL365697	133945	4	None	1	3	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	0	3	3.0	c1ccc(Cc2ccccc2OCCN2CCOCC2)cc1	10.1021/jm049720x
		134551	7146	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		271	7146	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		885	7146	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		CHEMBL1403281	7146	27	None	-28	21	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	nan
		2105	9828	37	None	-123	32	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		47811	9828	37	None	-123	32	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		48	9828	37	None	-123	32	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		CHEMBL531	9828	37	None	-123	32	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		DB01186	9828	37	None	-123	32	Human	5.7	pKi	=	5.7	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	10.1021/jm9800292
		25212275	181200	0	None	-4897	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL455288	181200	0	None	-4897	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		25212276	196845	0	None	-575	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL517244	196845	0	None	-575	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		135446209	16357	58	None	-22	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	298	0	2	5	3.1	Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1	10.1016/S0960-894X(96)00567-7
		CHEMBL1125	16357	58	None	-22	3	Human	6.7	pKi	=	6.7	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	298	0	2	5	3.1	Cc1cc2c(s1)Nc1ccccc1N=C2N1CCNCC1	10.1016/S0960-894X(96)00567-7
		71061709	156306	0	None	-14	12	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3946540	156306	0	None	-14	12	Mouse	5.7	pKi	=	5.7	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	372	6	0	4	3.5	Clc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		44582113	188414	0	None	-169	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	364	6	0	4	2.7	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477434	188414	0	None	-169	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	364	6	0	4	2.7	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		10474964	137249	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL368061	137249	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL5206021	137249	0	None	-8511	7	Bovine	5.7	pKi	=	5.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		5353853	24758	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		9556529	24758	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1262	24758	47	None	-19	15	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		127262	20252	12	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL1193274	20252	12	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		46227325	206906	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2C1	10.1016/j.bmc.2009.08.028
		CHEMBL596179	206906	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	1	2	3.4	CN1CCCc2cc(O)ccc2Cc2ccccc2C1	10.1016/j.bmc.2009.08.028
		71474079	150042	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3896731	150042	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	307	0	0	3	3.7	Cc1ccc(C)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		10550785	170211	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	433	4	1	2	5.9	Oc1cc2c(cc1Br)CCN(C/C=C/c1ccccc1)CC2c1ccccc1	10.1021/jm960143p
		CHEMBL419759	170211	0	None	-	1	Rat	6.7	pKi	=	6.7	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	433	4	1	2	5.9	Oc1cc2c(cc1Br)CCN(C/C=C/c1ccccc1)CC2c1ccccc1	10.1021/jm960143p
		53359025	69127	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2011.04.098
		CHEMBL1779058	69127	0	None	-2	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	339	5	1	3	2.5	O=C(CCCN1C2C3C4CC5C6C4C2C6C1(O)C53)c1ccc(F)cc1	10.1016/j.bmcl.2011.04.098
		6603703	6996	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		9637	6996	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		CHEMBL291143	6996	10	None	-1	5	Human	7.7	pKi	=	7.7	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm00018a002
		2389	10104	118	None	-489	66	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		5073	10104	118	None	-489	66	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		96	10104	118	None	-489	66	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		CHEMBL85	10104	118	None	-489	66	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		DB00734	10104	118	None	-489	66	Human	7.7	pKi	=	7.7	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm0002432
		13372	10531	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		86764100	10531	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		CHEMBL3697617	10531	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		DB14899	10531	30	None	-	1	Human	7.7	pKi	=	7.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		6603820	102549	19	None	-2	12	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
		CHEMBL25856	102549	19	None	-2	12	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm0604979
		135398737	7745	93	None	-44	90	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		38	7745	93	None	-44	90	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		722	7745	93	None	-44	90	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		CHEMBL42	7745	93	None	-44	90	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		DB00363	7745	93	None	-44	90	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2009.09.041
		75201901	173204	19	None	-1	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4277264	173204	19	None	-1	24	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		17756101	105360	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		CHEMBL276778	105360	1	None	-5	6	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCN(C)CCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		10903748	85251	0	None	-10	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL2111781	85251	0	None	-10	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		2435	10362	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		60149	10362	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		98	10362	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		CHEMBL12713	10362	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		DB06144	10362	83	None	-72	48	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	10.1021/jm030480f
		228	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		33	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		6005	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		CHEMBL53	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		DB00714	7233	28	None	-30	23	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		53364153	70615	0	None	-38	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	929	25	0	16	7.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCCCCCCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803023	70615	0	None	-38	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	929	25	0	16	7.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCCCCCCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		135398737	7745	93	None	-83	90	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		38	7745	93	None	-83	90	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		722	7745	93	None	-83	90	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		CHEMBL42	7745	93	None	-83	90	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		DB00363	7745	93	None	-83	90	Rat	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm100294b
		52945819	24325	0	None	-14	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	354	6	0	3	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
		CHEMBL1258037	24325	0	None	-14	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	354	6	0	3	4.2	Cc1ccc(C)c(N2CCN(CCCC(=O)c3ccc(F)cc3)CC2)c1	10.1021/jm100899z
		127047996	146424	0	None	-46	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	303	8	3	5	2.3	COc1ccccc1OCCNCCc1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		CHEMBL3797758	146424	0	None	-46	6	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	303	8	3	5	2.3	COc1ccccc1OCCNCCc1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		137636351	162652	0	None	-602	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	459	7	1	6	4.0	O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
		CHEMBL4060403	162652	0	None	-602	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	459	7	1	6	4.0	O=Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
		25072002	162893	0	None	-1047	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4063235	162893	0	None	-1047	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		122189388	130021	0	None	-40	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	483	7	0	8	3.8	O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		CHEMBL3613874	130021	0	None	-40	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	483	7	0	8	3.8	O=Cc1cnn2ccc(-n3cc(CCCN4CCN(c5cccc(Cl)c5Cl)CC4)nn3)cc12	10.1016/j.bmc.2015.07.050
		44300865	208774	0	None	-173	7	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/s0960-894x(02)00316-5
		CHEMBL60815	208774	0	None	-173	7	Bovine	5.7	pKi	=	5.7	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/s0960-894x(02)00316-5
		44340302	16524	0	None	-3	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL113471	16524	0	None	-3	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	466	7	1	3	5.3	COc1c(C(=O)NCC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		44340376	117423	0	None	-24	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL325818	117423	0	None	-24	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		54581963	68375	0	None	-7762	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	437	8	0	5	3.7	COc1ccc2c(c1)CCCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
		CHEMBL1771105	68375	0	None	-7762	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	437	8	0	5	3.7	COc1ccc2c(c1)CCCN(CCCCN1CCN(c3ccccc3OC)CC1)C2=O	10.1016/j.bmcl.2010.12.083
		44300865	208774	0	None	-173	7	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL60815	208774	0	None	-173	7	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	317	4	1	2	4.0	c1ccc(-c2c[nH]c(CN3CCN(c4ccccc4)CC3)c2)cc1	10.1016/j.bmcl.2006.02.075
		9980998	37808	0	None	-1819	7	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		CHEMBL139926	37808	0	None	-1819	7	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		CHEMBL2112911	37808	0	None	-1819	7	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm900095y
		45273442	203230	0	None	-100	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	403	3	0	5	4.3	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL563078	203230	0	None	-100	4	Bovine	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	403	3	0	5	4.3	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		44567594	179412	0	None	-34	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	339	4	2	4	4.0	CCCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		CHEMBL449461	179412	0	None	-34	2	Mouse	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	339	4	2	4	4.0	CCCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		49783040	24462	0	None	-446	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	395	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1	10.1021/jm100899z
		CHEMBL1258494	24462	0	None	-446	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	395	8	1	4	3.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cc(C)ccc2C)CC1	10.1021/jm100899z
		137660837	165859	0	None	-3019	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4097330	165859	0	None	-3019	5	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		11154555	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		5037	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		7671	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		CHEMBL2028019	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		CHEMBL3085826	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		DB06016	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		11154555	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		5037	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		7671	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		CHEMBL2028019	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		CHEMBL3085826	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		DB06016	7587	62	None	-1445	12	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.04.036
		15723715	20186	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL1192815	20186	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL544118	20186	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	337	1	2	3	4.0	CN1CCc2c(Cl)c(O)c(O)c(Cl)c2C(c2ccccc2)C1	10.1021/jm00116a004
		44316315	212298	0	None	-1318	5	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	215	2	0	3	2.1	CCCN1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
		CHEMBL80845	212298	0	None	-1318	5	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390Binding affinity of compound measured against Dopamine receptor D1 from bovine striatal membranes using radioligand [3H]-SCH- 23390	ChEMBL	215	2	0	3	2.1	CCCN1CCc2nn3ccccc3c2C1	10.1016/s0960-894x(02)00390-6
		44264622	103918	4	None	-72	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	327	3	0	5	2.7	Clc1ccc(N2CCN(Cc3cnc4ncccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL267853	103918	4	None	-72	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	327	3	0	5	2.7	Clc1ccc(N2CCN(Cc3cnc4ncccn34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		44412268	85142	9	None	-2089	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL211026	85142	9	None	-2089	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	319	4	0	5	2.6	c1ccc(N2CCN(Cc3cn(-c4ccccc4)nn3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		72544789	99907	0	None	-912	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	363	9	0	7	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443010	99907	0	None	-912	5	Pig	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	363	9	0	7	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		45379515	14228	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3[nH]c4ccccc4c3C21	10.1021/jm901291r
		CHEMBL1086789	14228	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	274	0	1	1	3.7	c1ccc2c(c1)CCN1CCc3[nH]c4ccccc4c3C21	10.1021/jm901291r
		44448027	161809	0	None	2	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	481	4	0	5	4.1	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL401567	161809	0	None	2	2	Rat	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	481	4	0	5	4.1	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		12301195	206495	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.2	COc1ccc2c(c1)CCN1CCc3ccccc3C21	10.1016/j.bmc.2009.08.028
		CHEMBL593395	206495	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	265	1	0	2	3.2	COc1ccc2c(c1)CCN1CCc3ccccc3C21	10.1016/j.bmc.2009.08.028
		9817779	121210	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL333246	121210	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		10085633	126774	0	None	-3	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	290	4	1	3	2.4	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCOCC1)CC2	10.1016/0960-894X(95)00076-6
		CHEMBL349997	126774	0	None	-3	2	Rat	5.7	pKi	=	5.7	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	290	4	1	3	2.4	CCc1c(C)[nH]c2c1C(=O)C(CCN1CCOCC1)CC2	10.1016/0960-894X(95)00076-6
		15654855	109440	0	None	4	2	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3cc(Cl)ccc32)CC1	10.1021/jm00067a009
		CHEMBL304493	109440	0	None	4	2	Rat	6.7	pKi	=	6.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3cc(Cl)ccc32)CC1	10.1021/jm00067a009
		2337	10030	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		50	10030	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		5002	10030	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		CHEMBL716	10030	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		DB01224	10030	77	None	-53	62	Human	6.7	pKi	=	6.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	nan
		9927411	209832	0	None	-89	4	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		CHEMBL63576	209832	0	None	-89	4	Rat	5.7	pKi	=	5.7	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	327	0	1	5	3.1	CN1CCN(C2=Nc3cccnc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		CHEMBL4566600	220793	0	None	-1	6	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1	ChEMBL		None	None	None		Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12	10.6019/CHEMBL5212743
		CHEMBL4745071	220793	0	None	-1	6	Human	5.7	pKi	=	5.7	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl DRD1	ChEMBL		None	None	None		Cc1c(C(=O)O)cc(-c2ccc(C3CCNCC3)cc2)c2ccc(-c3ccc(C(F)(F)F)cc3)cc12	10.6019/CHEMBL5212743
		112500026	139240	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697602	139240	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	0	5	4.1	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)ncc(=O)n1C	nan
		118711262	120734	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1cccc(-c2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325913	120734	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1cccc(-c2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
		9817779	121210	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		CHEMBL333246	121210	0	None	-2	2	Rat	6.7	pKi	=	6.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	299	1	0	4	2.9	CN1CCN(C2Cn3cccc3Sc3ccccc32)CC1	10.1021/jm010982y
		168290235	199747	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5201074	199747	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222491	199747	0	None	-1513	20	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	315	6	4	3	1.1	C[C@@H](NC(=O)/N=C(\N)NCCCc1ncn[nH]1)c1ccccc1	10.1021/acs.jmedchem.1c00692
		9998826	127255	0	None	-33113	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
		CHEMBL354210	127255	0	None	-33113	5	Bovine	4.7	pKi	=	4.7	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	363	5	1	3	3.1	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccccc1	10.1021/jm950759z
		2389	10104	118	None	-346	66	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		5073	10104	118	None	-346	66	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		96	10104	118	None	-346	66	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		CHEMBL85	10104	118	None	-346	66	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		DB00734	10104	118	None	-346	66	Rat	7.7	pKi	=	7.7	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/s0960-894x(98)00138-3
		9884087	21409	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	21409	0	None	-4	2	Rat	7.7	pKi	=	7.7	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		44415624	86880	0	None	19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213193	86880	0	None	19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415577	86920	0	None	20	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	436	2	1	7	3.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccon3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213372	86920	0	None	20	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	436	2	1	7	3.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccon3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		25142456	89181	2	None	-10	9	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		CHEMBL217299	89181	2	None	-10	9	Pig	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		439654	23270	39	None	9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL1235966	23270	39	None	9	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		21527771	76931	1	None	-8	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940404	76931	1	None	-8	10	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	363	6	1	3	4.2	OC1(c2ccc(Cl)cc2)CCN(CCCOc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		10903748	85251	0	None	-10	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL2111781	85251	0	None	-10	2	Rat	7.7	pKi	=	7.7	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN([C@H]2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		10830234	107153	0	None	20	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL289867	107153	0	None	20	2	Rat	7.7	pKi	=	7.7	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	3	3	4	4.1	CCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		11186523	134289	0	None	-15	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL366164	134289	0	None	-15	9	Human	7.7	pKi	=	7.7	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1C[C@@H]2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		44408818	146943	1	None	-12	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		CHEMBL380330	146943	1	None	-12	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		53361301	70616	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
		CHEMBL1803024	70616	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
		54585810	68378	0	None	-22	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3c(cccc3-c3ccccc3)C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771108	68378	0	None	-22	5	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3c(cccc3-c3ccccc3)C2=O)CC1	10.1016/j.bmcl.2010.12.083
		53361301	70616	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803024	70616	0	None	-14	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	985	29	0	16	8.6	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		53364226	70620	0	None	-67	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	989	29	0	18	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803028	70620	0	None	-67	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	989	29	0	18	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		118709160	120183	0	None	-18	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	846	18	0	8	10.1	O=C(CCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318832	120183	0	None	-18	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	846	18	0	8	10.1	O=C(CCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		118709161	120184	0	None	-83	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	860	19	0	8	10.5	O=C(CCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318833	120184	0	None	-83	4	Pig	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	860	19	0	8	10.5	O=C(CCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		10524751	64128	0	None	-1	4	Bovine	5.7	pKi	=	5.7	Binding	Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	395	5	0	1	6.5	CCCN(CCC)C1CCC(=C(C#Cc2ccccc2)C#Cc2ccccc2)CC1	10.1021/jm991098z
		CHEMBL165171	64128	0	None	-1	4	Bovine	5.7	pKi	=	5.7	Binding	Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	395	5	0	1	6.5	CCCN(CCC)C1CCC(=C(C#Cc2ccccc2)C#Cc2ccccc2)CC1	10.1021/jm991098z
		11036641	38552	0	None	-147	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		CHEMBL140612	38552	0	None	-147	4	Human	5.7	pKi	=	5.7	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	393	7	1	6	2.3	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm025558r
		11517928	83878	0	None	-18	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	444	4	0	6	4.3	Clc1ccc(N2CCN(Cc3cn4nc(N5CCCCC5)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
		CHEMBL207543	83878	0	None	-18	4	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	444	4	0	6	4.3	Clc1ccc(N2CCN(Cc3cn4nc(N5CCCCC5)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
		15548770	73224	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1802234	73224	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1852041	73224	0	None	-3	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	375	2	2	4	5.0	CN1CCc2cc(Sc3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		122181333	128652	0	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	366	8	1	2	3.8	CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		CHEMBL3590084	128652	0	None	-1548	6	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	366	8	1	2	3.8	CCCN(CCNC(=O)/C=C/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		57402365	76070	0	None	-169	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	441	12	1	6	3.1	CCOCCOc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928119	76070	0	None	-169	5	Pig	5.7	pKi	=	5.7	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	441	12	1	6	3.1	CCOCCOc1cccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
		44270558	172067	0	None	-812	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL423247	172067	0	None	-812	4	Bovine	5.7	pKi	=	5.7	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		44400553	77554	0	None	-2398	5	Pig	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL195083	77554	0	None	-2398	5	Pig	5.7	pKi	=	5.7	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		15467372	175889	0	None	-138	4	Bovine	4.7	pKi	=	4.7	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(99)00302-9
		CHEMBL440120	175889	0	None	-138	4	Bovine	4.7	pKi	=	4.7	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1[nH]ccc1CN1CCN(c2ccccc2)CC1	10.1016/s0960-894x(99)00302-9
		44264644	211522	0	None	-1737	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	330	3	0	4	3.2	Clc1ccc(N2CCN(Cc3cnn4c3CCCC4)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL7442	211522	0	None	-1737	4	Bovine	4.7	pKi	=	4.7	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	330	3	0	4	3.2	Clc1ccc(N2CCN(Cc3cnn4c3CCCC4)CC2)cc1	10.1016/s0960-894x(98)00692-1
		45269161	203114	0	None	-181	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	336	3	0	6	2.4	Cc1cc2nc(C)c(CN3CCN(c4ccccn4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL562384	203114	0	None	-181	4	Bovine	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	336	3	0	6	2.4	Cc1cc2nc(C)c(CN3CCN(c4ccccn4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		46850462	83337	0	None	-16	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccccc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
		CHEMBL2062849	83337	0	None	-16	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccccc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
		46850464	83339	0	None	-87	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
		CHEMBL2062851	83339	0	None	-87	3	Human	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
		5353432	104271	89	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
		CHEMBL270299	104271	89	None	-1	3	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	249	2	0	3	2.8	CC(C)(C)c1ccc(S(=O)(=O)/C=C/C#N)cc1	nan
		45481889	205794	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	637	10	2	10	5.4	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5nsc6ccccc56)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
		CHEMBL585741	205794	0	None	-1	3	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	637	10	2	10	5.4	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5nsc6ccccc56)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
		90644062	118811	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289647	118811	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		90644062	118811	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289647	118811	0	None	-11	5	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	345	6	0	4	3.8	Cc1ccc(N2CCN(CCCSc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		44448065	162259	0	None	-2	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL404037	162259	0	None	-2	2	Rat	4.7	pKi	=	4.7	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		117773891	139203	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	379	5	1	6	3.1	Cc1cc(Oc2ncccc2OC2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697566	139203	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	379	5	1	6	3.1	Cc1cc(Oc2ncccc2OC2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		145979741	173464	1	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4282096	173464	1	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	291	3	0	5	4.0	Cn1nccc1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		46231835	207611	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	410	2	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCCCC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL600998	207611	0	None	-8	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	410	2	1	3	5.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cc(CN4CCCCC4)ccc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL1200633	215379	3	None	-7	8	Human	5.7	pKi	=	5.7	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(CC[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		112500027	139241	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697603	139241	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		44320257	212954	0	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL86325	212954	0	None	-5	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	5	3	5	2.3	NC[C@@H]1OC(COCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		49783209	24381	0	None	-3981	26	Rat	5.6	pKi	=	5.6	Binding	Binding affinity to rat dopamine D1 receptorBinding affinity to rat dopamine D1 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		CHEMBL1258223	24381	0	None	-3981	26	Rat	5.6	pKi	=	5.6	Binding	Binding affinity to rat dopamine D1 receptorBinding affinity to rat dopamine D1 receptor	ChEMBL	396	7	1	6	3.8	CCCCN1CCC(COC(=O)c2cc(Cl)c(NC)c3c2OCCO3)CC1	10.1021/jm100668r
		19795148	123368	0	None	97	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	265	0	1	2	3.3	CN1CCc2cc(Cl)c(O)cc2C2(CCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL336610	123368	0	None	97	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	265	0	1	2	3.3	CN1CCc2cc(Cl)c(O)cc2C2(CCCC2)C1	10.1016/S0960-894X(00)80155-9
		44447998	162172	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	363	6	0	3	5.3	CCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		CHEMBL403550	162172	0	None	3	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	363	6	0	3	5.3	CCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		44415844	86901	0	None	20	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3nccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213278	86901	0	None	20	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3nccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		17756102	92919	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	309	1	0	2	4.1	COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2	10.1021/jm070388+
		CHEMBL231171	92919	0	None	2	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	309	1	0	2	4.1	COc1ccc2c(c1)CCCN(C)CCCc1ccccc1C2	10.1021/jm070388+
		15069442	107477	0	None	104	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		CHEMBL292451	107477	0	None	104	2	Rat	7.6	pKi	=	7.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		71110293	150157	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	150157	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		71110293	150157	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	150157	0	None	6	3	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		70682088	82843	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057446	82843	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	0	6	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		117773010	139231	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.9	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C	nan
		CHEMBL3697593	139231	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.9	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C	nan
		10947658	35475	0	None	-208	16	Mouse	6.6	pKi	=	6.6	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL137781	35475	0	None	-208	16	Mouse	6.6	pKi	=	6.6	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		6603954	209384	2	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL612083	209384	2	None	-81	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		11392229	69753	0	None	-15	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	293	1	0	3	2.9	Cc1ccc2n1Cc1ccccc1C=C2N1CCN(C)CC1	10.1021/jm049629t
		CHEMBL178564	69753	0	None	-15	4	Rat	6.6	pKi	=	6.6	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	293	1	0	3	2.9	Cc1ccc2n1Cc1ccccc1C=C2N1CCN(C)CC1	10.1021/jm049629t
		44360984	41855	0	None	-208	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1	10.1021/jm025558r
		CHEMBL143352	41855	0	None	-208	6	Human	5.6	pKi	=	5.6	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	407	8	1	6	2.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cccn3nccc23)CC1	10.1021/jm025558r
		11516033	145896	5	None	-1949	6	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	360	3	0	4	4.0	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl	10.1021/jm060166w
		CHEMBL378680	145896	5	None	-1949	6	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	360	3	0	4	4.0	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1Cl	10.1021/jm060166w
		54583897	68376	0	None	-1445	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	411	7	0	4	3.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(F)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771106	68376	0	None	-1445	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	411	7	0	4	3.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(F)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		53363109	70622	0	None	-691	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	465	11	0	8	4.0	CCCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803030	70622	0	None	-691	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	465	11	0	8	4.0	CCCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		137660046	166122	0	None	-3235	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	437	7	2	8	2.4	O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4100183	166122	0	None	-3235	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	437	7	2	8	2.4	O=C1COc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2N1	10.1021/acs.jmedchem.7b00363
		52937871	67946	0	None	-588	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	458	11	1	5	4.6	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(C=O)c2C1	10.1021/jm101639t
		CHEMBL1765631	67946	0	None	-588	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	458	11	1	5	4.6	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(C=O)c2C1	10.1021/jm101639t
		122177644	127990	0	None	-19054	6	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
		CHEMBL3577345	127990	0	None	-19054	6	Human	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
		56926585	75780	0	None	-5495	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	358	4	0	5	2.9	COc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
		CHEMBL1923293	75780	0	None	-5495	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	358	4	0	5	2.9	COc1cc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)ccc1F	10.1021/jm200762g
		44381424	65845	0	None	-190	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
		CHEMBL169562	65845	0	None	-190	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
		44381432	127496	0	None	-6	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
		CHEMBL354748	127496	0	None	-6	4	Bovine	4.6	pKi	=	4.6	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	3	1	4	2.6	c1ccc(C2=NC[C@@H](N3CCN(c4ccccc4)CC3)CCN2)cc1	10.1016/s0960-894x(03)00004-0
		72301	192897	76	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL487182	192897	76	None	1	4	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		44591134	182979	0	None	-194	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL459373	182979	0	None	-194	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		154726381	183306	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4522558	183306	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4597048	183306	1	None	-446	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	509	12	1	3	7.1	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@H]1C[C@@H]1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		90644057	118809	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289645	118809	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		90644057	118809	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289645	118809	0	None	-190	4	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	365	6	0	4	3.7	FC(F)(F)c1ccc(OCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		145992269	173732	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4287192	173732	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	343	3	0	7	4.0	Cc1cc(Oc2nccc3occc23)ccc1-c1cncc2ncnn12	10.1021/acs.jmedchem.8b01622
		46227273	206590	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	3	0	2	3.8	COc1ccc2c(c1)CCN(C)C2Cc1ccccc1C	10.1016/j.bmc.2009.08.028
		CHEMBL594127	206590	0	None	2	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	3	0	2	3.8	COc1ccc2c(c1)CCN(C)C2Cc1ccccc1C	10.1016/j.bmc.2009.08.028
		135398737	7745	93	None	-83	90	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		38	7745	93	None	-83	90	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		722	7745	93	None	-83	90	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		CHEMBL42	7745	93	None	-83	90	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		DB00363	7745	93	None	-83	90	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9810396
		14198576	204667	0	None	-2	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	3	1	2	3.8	COc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL572720	204667	0	None	-2	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	3	1	2	3.8	COc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		228	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		33	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		6005	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		CHEMBL53	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		DB00714	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00004a011
		228	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		33	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		6005	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		CHEMBL53	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		DB00714	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		228	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		33	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		6005	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		CHEMBL53	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		DB00714	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960188q
		228	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		33	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		6005	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		CHEMBL53	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		DB00714	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm960189i
		44415613	84842	0	None	15	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	543	3	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCN(C)CC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL210016	84842	0	None	15	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	543	3	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCN(C)CC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		72708061	98974	0	None	-1	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425372	98974	0	None	-1	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	309	1	0	4	3.1	COc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL5274285	200585	0	None	-20	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constantDisplacement of [3H]SCH23390 from D1 receptor in HEK293 cell membrane assessed as inhibition constant	ChEMBL	415	4	1	2	5.3	Fc1ccc(CN2CCCC23CCN(Cc2cc4ccc(Cl)cc4[nH]2)C3)cc1F	10.1016/j.ejmech.2022.114840
		44415645	146122	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	613	4	1	7	6.5	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc4c(c3)OCCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL379286	146122	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	613	4	1	7	6.5	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc4c(c3)OCCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		44209480	76945	0	None	-218	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940418	76945	0	None	-218	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	313	6	0	3	3.4	Fc1ccc(CCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		10264172	17205	0	None	-7413	2	Rat	4.6	pKi	=	4.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	2	2	3.1	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960188q
		CHEMBL116367	17205	0	None	-7413	2	Rat	4.6	pKi	=	4.6	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	251	0	2	2	3.1	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm960188q
		3037308	50853	27	None	-99	6	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	452	7	1	7	4.2	O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm9810396
		CHEMBL151475	50853	27	None	-99	6	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	452	7	1	7	4.2	O=c1c(CO)coc2cc(OCCCN3CCC(c4noc5cc(F)ccc45)CC3)ccc12	10.1021/jm9810396
		9928073	210428	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00030a011
		CHEMBL67284	210428	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00030a011
		10108504	45680	0	None	6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3ccccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		CHEMBL146741	45680	0	None	6	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3ccccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		44582518	188372	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.6	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477055	188372	0	None	-10	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.6	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1016/j.bmcl.2009.01.067
		3036864	209533	19	None	-2	27	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	209533	19	None	-2	27	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	209533	19	None	-2	27	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	209533	19	None	-2	27	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		44385451	66366	0	None	-7	2	Rat	7.6	pKi	=	7.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	284	3	0	2	3.9	Cc1cccc2c1C(CN(C)C)CN2c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
		CHEMBL171903	66366	0	None	-7	2	Rat	7.6	pKi	=	7.6	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	284	3	0	2	3.9	Cc1cccc2c1C(CN(C)C)CN2c1ccc(F)cc1	10.1016/s0960-894x(98)00138-3
		13838745	101507	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
		CHEMBL25305	101507	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	281	1	3	3	2.9	Oc1cc2c3c(c1O)CC[C@@H]3CNC[C@@H]2c1ccccc1	10.1021/jm00170a025
		1353	8692	93	None	-74	85	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		3559	8692	93	None	-74	85	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		86	8692	93	None	-74	85	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		CHEMBL54	8692	93	None	-74	85	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		DB00502	8692	93	None	-74	85	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00391a028
		15937721	25877	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	255	2	1	3	2.6	CCOC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL128917	25877	0	None	-	1	Rat	7.6	pKi	=	7.6	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	255	2	1	3	2.6	CCOC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		44415670	145694	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	565	2	1	5	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL378341	145694	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	565	2	1	5	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)ccc3C(F)(F)F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415745	173101	0	None	25	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL427230	173101	0	None	25	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(Cl)cc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		86764211	139224	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697587	139224	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		90140334	136191	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc2n[nH]cc2c(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)n1	nan
		CHEMBL3671270	136191	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc2n[nH]cc2c(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)n1	nan
		44276535	105165	0	None	50	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
		CHEMBL275379	105165	0	None	50	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	282	0	3	4	2.4	Cc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
		10432808	65523	0	None	-6	4	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		CHEMBL168611	65523	0	None	-6	4	Bovine	6.6	pKi	=	6.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		2389	10104	118	None	-489	66	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		5073	10104	118	None	-489	66	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		96	10104	118	None	-489	66	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		CHEMBL85	10104	118	None	-489	66	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		DB00734	10104	118	None	-489	66	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	nan
		10042942	162281	0	None	3	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1OC)-c1c(OC)c(O)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL404136	162281	0	None	3	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1OC)-c1c(OC)c(O)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		137642380	165286	0	None	-48	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	431	6	1	5	4.2	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1	10.1021/acs.jmedchem.6b01857
		CHEMBL4091155	165286	0	None	-48	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	431	6	1	5	4.2	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2nccc2c1	10.1021/acs.jmedchem.6b01857
		90644227	118557	0	None	-186	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287396	118557	0	None	-186	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	448	8	1	6	4.1	OCc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		228	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		33	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		6005	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		CHEMBL53	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		DB00714	7233	28	None	-30	23	Rat	6.6	pKi	=	6.6	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		9928073	210428	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL67284	210428	0	None	-7	3	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	343	0	0	4	4.1	CN1CCN(C2=Nc3cc(Cl)ccc3Sc3ccccc32)CC1	10.1021/jm00067a009
		53362716	70736	0	None	-26	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
		CHEMBL1806871	70736	0	None	-26	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
		49783039	24425	0	None	-954	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	421	7	1	4	4.9	Cc1ccc(C)c(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1	10.1021/jm100899z
		CHEMBL1258383	24425	0	None	-954	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	421	7	1	4	4.9	Cc1ccc(C)c(N2CCN(CCCCNC(=O)c3cc4ccccc4s3)CC2)c1	10.1021/jm100899z
		57400557	76087	0	None	-1995	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	509	14	1	8	3.2	CCOCCOCc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928136	76087	0	None	-1995	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	509	14	1	8	3.2	CCOCCOCc1ccn2ncc(C(=O)NCCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		15654854	109032	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cccnc3Nc3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL303173	109032	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3cccnc3Nc3ccccc32)CC1	10.1021/jm00067a009
		11589069	103022	0	None	-1479	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
		CHEMBL260994	103022	0	None	-1479	8	Human	5.6	pKi	=	5.6	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	383	6	1	3	4.4	O=C1Nc2ccccc2C1CCCCN1CCN(c2ccc(Cl)cc2)CC1	10.1021/jm070279v
		15115513	115457	0	None	-218	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL320779	115457	0	None	-218	2	Human	4.6	pKi	=	4.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		681	8247	72	None	-154	38	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		940	8247	72	None	-154	38	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		947	8247	72	None	-154	38	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		CHEMBL59	8247	72	None	-154	38	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		DB00988	8247	72	None	-154	38	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/acs.jmedchem.8b01622
		44299917	176228	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@@H]21	10.1021/jm00128a038
		CHEMBL442740	176228	0	None	-	1	Rat	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)CCN(C)[C@H]1CCc3ccccc3[C@@H]21	10.1021/jm00128a038
		90134304	173293	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
		CHEMBL4278861	173293	1	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	5.0	Cc1cc(Oc2nccc3occc23)ccc1-n1c(C)nc2cnccc21	10.1021/acs.jmedchem.8b01622
		71562963	94351	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2335741	94351	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		10691657	126692	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	387	3	0	3	5.1	CCCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		CHEMBL349311	126692	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	387	3	0	3	5.1	CCCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		168294767	199798	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5207281	199798	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		CHEMBL5222802	199798	0	None	-457	20	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	313	8	4	5	0.9	CCCCCNC(=O)/N=C(\N)NCCCc1nnc(N)s1	10.1021/acs.jmedchem.1c00692
		117773347	139205	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	378	4	1	6	2.8	Cc1cc(Oc2ncccc2N2CCC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697568	139205	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	378	4	1	6	2.8	Cc1cc(Oc2ncccc2N2CCC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		71110290	153938	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3927835	153938	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)C1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		15711860	20630	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL1195937	20630	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL555619	20630	0	None	-1	2	Goldfish	6.6	pKi	=	6.6	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	285	3	2	4	2.7	COc1ccc2c(c1O)C[C@@H](c1ccccc1)O[C@H]2CN	10.1021/jm00114a002
		14198588	178286	2	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL446396	178286	2	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
		44320001	212795	0	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL84983	212795	0	None	2	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	299	4	3	4	2.7	NC[C@@H]1OC(CCc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44591135	196956	0	None	-158	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	532	10	0	4	8.0	CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL517407	196956	0	None	-158	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	532	10	0	4	8.0	CN(CC/C=C1\c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		71110293	150157	0	None	6	3	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		CHEMBL3897805	150157	0	None	6	3	Human	6.6	pKi	=	6.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCO4	nan
		135398745	9688	112	None	-23	65	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
		47	9688	112	None	-23	65	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
		CHEMBL715	9688	112	None	-23	65	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
		DB00334	9688	112	None	-23	65	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm800689g
		1353	8692	93	None	-38	85	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		3559	8692	93	None	-38	85	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		86	8692	93	None	-38	85	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		CHEMBL54	8692	93	None	-38	85	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		DB00502	8692	93	None	-38	85	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH233930 from human D1 receptor expressed in HEK cellsDisplacement of [3H]SCH233930 from human D1 receptor expressed in HEK cells	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2011.04.098
		1242	10385	27	None	-5	17	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		935	10385	27	None	-5	17	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		CHEMBL286080	10385	27	None	-5	17	Human	7.6	pKi	=	7.6	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00116a004
		75306277	116031	0	None	-12	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		CHEMBL3217984	116031	0	None	-12	23	Human	7.6	pKi	=	7.6	Binding	Binding affinity to dopamine D1 receptor (unknown origin) by PDSP assayBinding affinity to dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	308	0	0	3	4.2	CN1CCC2C(C1)c1cccc3c1N2c1ccccc1CS3	10.1039/C2MD00311B
		9884087	21409	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	21409	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		71474026	161078	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
		CHEMBL3986624	161078	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	353	2	0	5	3.1	COc1ccc(OC)c2c1C[C@H]1c3cc4c(cc3CCN1C2)OCCO4	nan
		11718008	82066	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		CHEMBL203734	82066	0	None	-1	4	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	349	1	0	2	4.6	COc1c(Cl)cc2c(c1Cl)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		44415954	87876	0	None	72	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	467	6	1	5	5.4	CCCC(CCC)C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL215581	87876	0	None	72	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	467	6	1	5	5.4	CCCC(CCC)C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		135398745	9688	112	None	-26	65	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		47	9688	112	None	-26	65	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		CHEMBL715	9688	112	None	-26	65	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		DB00334	9688	112	None	-26	65	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm030480f
		53364154	70617	0	None	-13	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1013	31	0	16	9.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803025	70617	0	None	-13	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1013	31	0	16	9.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		45273443	202410	0	None	-66	4	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	392	4	1	6	2.2	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL556288	202410	0	None	-66	4	Bovine	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	392	4	1	6	2.2	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		137644966	165273	0	None	-363	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	456	6	1	6	4.1	N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
		CHEMBL4091064	165273	0	None	-363	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	456	6	1	6	4.1	N#Cc1cnn2ccc(NC(=O)CCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/acs.jmedchem.6b01857
		122191607	130500	0	None	-346	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	468	9	1	3	5.0	CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1	10.1021/acsmedchemlett.5b00131
		CHEMBL3622099	130500	0	None	-346	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	468	9	1	3	5.0	CCCN(CCN1CCN(CCc2c[nH]c3ccccc23)CC1)c1ccc(Br)cc1	10.1021/acsmedchemlett.5b00131
		56837636	76072	0	None	-177	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	897	28	2	13	5.1	COc1ccccc1N1CCN(CCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928121	76072	0	None	-177	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	897	28	2	13	5.1	COc1ccccc1N1CCN(CCCNC(=O)c2cccc(OCCOCCOCCOCCOc3cccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)c3)c2)CC1	10.1016/j.bmc.2011.10.063
		44401042	131607	0	None	-67	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL364270	131607	0	None	-67	9	Human	6.6	pKi	=	6.6	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		11575799	84904	0	None	-2511	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	438	3	0	4	4.7	Clc1ccc(N2CCN(Cc3cn4cc(Br)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
		CHEMBL210341	84904	0	None	-2511	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	438	3	0	4	4.7	Clc1ccc(N2CCN(Cc3cn4cc(Br)ccc4n3)CC2)cc1Cl	10.1021/jm060166w
		25256814	188391	0	None	-1318	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL477250	188391	0	None	-1318	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	0	4	3.3	COc1ccccc1N1CCN(CCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		53363110	70625	0	None	-194	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	507	14	0	8	4.8	CCCCn1cc(CCCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803050	70625	0	None	-194	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	507	14	0	8	4.8	CCCCn1cc(CCCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		24823922	167572	0	None	-15	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
		CHEMBL411437	167572	0	None	-15	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
		11725531	60828	2	None	-1659	5	Bovine	5.6	pKi	=	5.6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	351	3	0	5	3.2	N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL160626	60828	2	None	-1659	5	Bovine	5.6	pKi	=	5.6	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	351	3	0	5	3.2	N#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		15522515	104937	0	None	-1479	4	Bovine	4.6	pKi	=	4.6	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	292	3	0	4	2.7	c1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL273860	104937	0	None	-1479	4	Bovine	4.6	pKi	=	4.6	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	292	3	0	4	2.7	c1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		71734028	97828	0	None	-7762	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
		CHEMBL2397390	97828	0	None	-7762	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
		2389	10104	118	None	-346	66	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		5073	10104	118	None	-346	66	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		96	10104	118	None	-346	66	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		CHEMBL85	10104	118	None	-346	66	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		DB00734	10104	118	None	-346	66	Rat	6.6	pKi	=	6.6	Binding	Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.Binding affinity measured at the Dopamine receptor D1 by the inhibition of [3H]SCH-23390 binding to rat striatum using unlabeled apomorphine for nonspecific binding.	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm9810396
		44320002	113818	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL315535	113818	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	4	2	4	3.2	C#CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44582491	188334	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	6	0	4	3.3	COc1ccccc1N1CCN(CCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476641	188334	0	None	-12	3	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	6	0	4	3.3	COc1ccccc1N1CCN(CCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		10022123	60090	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL159969	60090	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL92673	60090	0	None	-28	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	371	5	0	4	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3sccc3C2=O)CC1	10.1021/jm981094e
		71562966	94348	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
		CHEMBL2335738	94348	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
		44478261	199076	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	0	3	6	3.0	CN1CCc2c3c(cc4nc(N)sc24)-c2c(ccc(O)c2O)C[C@H]31	10.1016/j.bmc.2008.05.077
		CHEMBL520610	199076	0	None	-7	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	0	3	6	3.0	CN1CCc2c3c(cc4nc(N)sc24)-c2c(ccc(O)c2O)C[C@H]31	10.1016/j.bmc.2008.05.077
		175	10427	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
		68186	10427	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
		CHEMBL79834	10427	44	None	-831	7	Mouse	5.6	pKi	=	5.6	Binding	Tested for binding affinity against dopamine receptor D1Tested for binding affinity against dopamine receptor D1	ChEMBL	383	6	1	4	3.0	Fc1ccc(cc1)OCCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00069a010
		145988779	174058	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
		CHEMBL4293356	174058	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	305	3	0	5	4.3	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C	10.1021/acs.jmedchem.8b01622
		72164182	98925	0	None	-41	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	3	0	3	4.4	Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl	10.1016/j.bmcl.2013.07.033
		CHEMBL2420777	98925	0	None	-41	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	326	3	0	3	4.4	Clc1ccc(N2CCN(Cc3cccs3)CC2)cc1Cl	10.1016/j.bmcl.2013.07.033
		10092819	23545	0	None	-2454	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
		CHEMBL124444	23545	0	None	-2454	11	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	407	8	1	5	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm0211220
		44415647	146018	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	639	5	1	6	7.6	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL378893	146018	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	639	5	1	6	7.6	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc(OC(F)(F)F)c3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		164612037	192156	0	None	-144	20	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		CHEMBL4860528	192156	0	None	-144	20	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from human D1 receptor stably expressed in HEK293T cells co-expressing luciferase and CEK incubated for 60 mins by scintillation counting analysis	ChEMBL	326	8	4	4	1.8	CCCCCNC(=O)/N=C(\N)NCCCc1sc(N)nc1C	10.1021/acs.jmedchem.1c00692
		57396484	76944	2	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	316	6	0	5	2.2	Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940417	76944	2	None	-61	6	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	316	6	0	5	2.2	Fc1ccc(OCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		13015797	212676	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	400	6	0	5	3.7	COc1cc2c(cc1OC)C(CCN1CCN(c3ccc(F)cc3)CC1)OCC2	10.1021/jm960084f
		CHEMBL83915	212676	0	None	-1	4	Rat	7.6	pKi	=	7.6	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	400	6	0	5	3.7	COc1cc2c(cc1OC)C(CCN1CCN(c3ccc(F)cc3)CC1)OCC2	10.1021/jm960084f
		44415836	86911	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	4	1	5	5.9	CCCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213335	86911	0	None	15	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	507	4	1	5	5.9	CCCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		70607606	183983	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	333	1	3	3	3.1	Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4635277	183983	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	333	1	3	3	3.1	Oc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
		6852376	98374	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
		CHEMBL1467585	98374	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
		CHEMBL24077	98374	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
		CHEMBL503958	98374	13	None	-3	5	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1016/j.bmc.2008.09.049
		72699812	121964	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	315	2	1	4	3.7	CCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344456	121964	0	None	1	3	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	315	2	1	4	3.7	CCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		10566865	122757	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL335515	122757	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		10015045	20424	1	None	-2	6	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		CHEMBL119455	20424	1	None	-2	6	Rat	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		86764215	139235	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697597	139235	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		14198587	209910	1	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm00129a006
		CHEMBL64117	209910	1	None	5	2	Human	7.6	pKi	=	7.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2[C@@H]1Cc1ccccc1	10.1021/jm00129a006
		11728201	20751	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL119687	20751	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9884087	21409	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL120512	21409	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		15115514	15843	0	None	-54	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL109897	15843	0	None	-54	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		90644061	118810	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289646	118810	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		136056636	118565	0	None	-309	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287404	118565	0	None	-309	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		118709174	120199	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	946	23	0	10	9.6	CN(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)CCN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318847	120199	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	946	23	0	10	9.6	CN(CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)CCN(C)CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		10917953	214767	0	None	-7585	10	Rat	5.6	pKi	=	5.6	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	489	6	0	8	3.6	Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		CHEMBL97242	214767	0	None	-7585	10	Rat	5.6	pKi	=	5.6	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	489	6	0	8	3.6	Cn1nnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		71583849	94507	0	None	-147	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(-n2cc(CN3CCN(c4cc5ccc4CCc4ccc(cc4)CC5)CC3)cn2)cc1	10.1016/j.bmc.2013.01.065
		CHEMBL2336893	94507	0	None	-147	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	448	4	0	4	5.1	c1ccc(-n2cc(CN3CCN(c4cc5ccc4CCc4ccc(cc4)CC5)CC3)cn2)cc1	10.1016/j.bmc.2013.01.065
		14659268	86413	2	None	-35	3	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1016/j.bmc.2008.02.038
		CHEMBL2115032	86413	2	None	-35	3	Mouse	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	10.1016/j.bmc.2008.02.038
		122180956	128549	0	None	-263	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	404	7	1	3	4.8	CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		CHEMBL3589577	128549	0	None	-263	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	404	7	1	3	4.8	CCCN(CCNC(=O)/N=N/c1cc(F)c(F)c(F)c1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		122177641	127987	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
		CHEMBL3577342	127987	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
		72544566	99906	0	None	-1318	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	375	10	0	6	3.1	COc1ccccc1N1CCN(Cc2cn(CCCCCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443009	99906	0	None	-1318	5	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	375	10	0	6	3.1	COc1ccccc1N1CCN(Cc2cn(CCCCCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		9865384	180274	35	None	-30902	7	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
		CHEMBL45305	180274	35	None	-30902	7	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	393	5	1	3	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3ccc(F)c(Cl)c3)CC2)nc1	10.1021/jm100835q
		10014924	114048	0	None	-1548	5	Bovine	4.6	pKi	=	4.6	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL316983	114048	0	None	-1548	5	Bovine	4.6	pKi	=	4.6	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
		11472028	73541	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	1	3	3.2	OC(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
		CHEMBL185875	73541	0	None	2	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	6	1	3	3.2	OC(c1ccccc1)c1ccccc1OCCN1CCCC1	10.1021/jm049720x
		15711855	20184	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL1192799	20184	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL544099	20184	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	289	3	2	3	3.5	CNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		11696813	194697	12	None	-316	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm100294b
		CHEMBL496739	194697	12	None	-316	9	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm100294b
		90644061	118810	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289646	118810	0	None	-239	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	6	0	4	3.1	Cc1ccc(N2CCN(CCCOc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		72708126	98977	0	None	-7	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425375	98977	0	None	-7	2	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		14198588	178286	2	None	2	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		CHEMBL446396	178286	2	None	2	2	Rat	4.6	pKi	=	4.6	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		57401706	76946	0	None	-45	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940419	76946	0	None	-45	11	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	331	6	0	4	3.5	Fc1ccc(SCCCN2CCN(c3ccccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		44320218	213203	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
		CHEMBL87897	213203	0	None	1	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	5	2.3	COc1ccc(CC2Cc3c(ccc(O)c3O)[C@H](CN)O2)cc1	10.1021/jm00112a034
		10993765	85542	0	None	-10	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	433	5	0	5	4.1	COc1ccccc1N1CCN(CC2CCN(C(=O)c3cc4ccccc4o3)CC2)CC1	10.1021/jm0211220
		CHEMBL2112643	85542	0	None	-10	2	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	433	5	0	5	4.1	COc1ccccc1N1CCN(CC2CCN(C(=O)c3cc4ccccc4o3)CC2)CC1	10.1021/jm0211220
		91899757	136218	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-n1c(C)nc2cnccc21	nan
		CHEMBL3671296	136218	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	356	3	1	6	4.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-n1c(C)nc2cnccc21	nan
		1971	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		2404	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		4543	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		CHEMBL445	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		DB00540	9641	38	None	-8	30	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	nan
		25256816	188387	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477206	188387	0	None	-4168	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		9884087	21409	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		CHEMBL120512	21409	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm9706832
		21533446	76930	0	None	-7	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		CHEMBL1940403	76930	0	None	-7	10	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	379	6	1	3	4.9	OC1(c2ccc(Cl)cc2)CCN(CCCSc2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.07.018
		11728201	20751	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL119687	20751	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	363	3	1	5	3.0	OCCN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		9884087	21409	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL120512	21409	0	None	-4	2	Rat	7.6	pKi	=	7.6	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	333	1	0	4	3.6	CN1CCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		70684965	84609	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL2092940	84609	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		1353	8692	93	None	-38	85	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		3559	8692	93	None	-38	85	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		86	8692	93	None	-38	85	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		CHEMBL54	8692	93	None	-38	85	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		DB00502	8692	93	None	-38	85	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm030480f
		44249745	202222	1	None	-363	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
		CHEMBL552373	202222	1	None	-363	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
		CHEMBL567286	202222	1	None	-363	5	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranesDisplacement of [3H]SCH 23990 from dopamine D1 receptor in porcine cerebral cortex membranes	ChEMBL	366	4	0	3	3.1	N#Cc1cccc(N2CCN(CCN3CCC(C(F)(F)F)CC3)C2=O)c1	10.1016/j.bmcl.2010.09.142
		24878061	148189	0	None	25	2	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
		CHEMBL384046	148189	0	None	25	2	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@@H]1c3ccccc3CN[C@H]1CO2	10.1021/jm0604979
		10061323	18678	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL118254	18678	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
		53364227	70621	0	None	-50	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1033	32	0	19	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803029	70621	0	None	-50	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1033	32	0	19	6.3	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCOCCOCCOCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		10061323	18678	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL118254	18678	0	None	-60	4	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	263	1	0	1	4.0	CCc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		11405107	205842	0	None	-32	4	Bovine	5.6	pKi	=	5.6	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	341	3	1	2	3.7	C(#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1)c1ccccc1	10.1016/s0960-894x(02)00316-5
		CHEMBL58662	205842	0	None	-32	4	Bovine	5.6	pKi	=	5.6	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	341	3	1	2	3.7	C(#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1)c1ccccc1	10.1016/s0960-894x(02)00316-5
		44403210	77318	0	None	-630	5	Pig	5.6	pKi	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	385	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
		CHEMBL194727	77318	0	None	-630	5	Pig	5.6	pKi	=	5.6	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	385	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
		9970201	177422	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
		CHEMBL445129	177422	0	None	-	1	Rat	5.6	pKi	=	5.6	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	267	0	2	3	2.6	Oc1cc2c(cc1O)C1c3ccccc3CCN1CC2	10.1021/jm00051a008
		52938728	65328	0	None	-1000	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684028	65328	0	None	-1000	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	606	12	0	8	6.0	CCCN1CCc2cccc3c2C1Cc1cccc(OCc2cn(CCCCN4CCN(c5ccccc5OC)CC4)nn2)c1-3	10.1016/j.bmc.2011.01.053
		137636066	163012	0	None	-1698	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	480	7	3	7	3.0	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4064742	163012	0	None	-1698	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	480	7	3	7	3.0	O=C1CCc2ccc(OCCCCN3CCCN(c4ccc(O)c5c4OCC(=O)N5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		4150	7575	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		5288	7575	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		644019	7575	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		CHEMBL190461	7575	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		DB09061	7575	39	None	-69	12	Human	5.6	pKi	=	5.6	Binding	Inhibition of D1 dopamine receptor (unknown origin)Inhibition of D1 dopamine receptor (unknown origin)	ChEMBL	314	6	2	2	5.8	CCCCCc1cc(O)c(c(c1)O)[C@@H]1C=C(C)CC[C@H]1C(=C)C	10.1021/acs.jmedchem.0c00724
		11689612	86614	0	None	-28840	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	388	5	0	7	2.9	COc1ccccc1N1CCN(Cc2cn3c(-n4cccn4)cccc3n2)CC1	10.1021/jm060166w
		CHEMBL212160	86614	0	None	-28840	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	388	5	0	7	2.9	COc1ccccc1N1CCN(Cc2cn3c(-n4cccn4)cccc3n2)CC1	10.1021/jm060166w
		44412269	84875	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL210232	84875	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2006.02.075
		44412269	84875	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL210232	84875	0	None	-10000	4	Pig	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	349	5	0	6	2.6	COc1ccccc1N1CCN(Cc2cn(-c3ccccc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		45271653	202014	0	None	-2238	4	Bovine	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)ncn34)CC2)cc1	10.1016/j.bmc.2009.05.015
		CHEMBL550920	202014	0	None	-2238	4	Bovine	4.6	pKi	=	4.6	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)ncn34)CC2)cc1	10.1016/j.bmc.2009.05.015
		10046389	68190	0	None	-1122	5	Bovine	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
		CHEMBL177031	68190	0	None	-1122	5	Bovine	4.6	pKi	=	4.6	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	397	5	1	3	3.8	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(Cl)cc1	10.1021/jm950759z
		135	9310	43	None	-91	56	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		1796	9310	43	None	-91	56	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		4184	9310	43	None	-91	56	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		CHEMBL6437	9310	43	None	-91	56	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		DB06148	9310	43	None	-91	56	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	nan
		44406077	139596	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
		CHEMBL370136	139596	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
		90644071	118819	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	368	5	0	3	5.2	Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289655	118819	0	None	-1	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	368	5	0	3	5.2	Clc1ccc(N2CCCN(CCCc3cc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		131396	213514	6	None	-549	5	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligandCompound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligand	ChEMBL	435	6	0	5	4.6	CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1	10.1021/jm00092a024
		CHEMBL89934	213514	6	None	-549	5	Rat	5.6	pKi	=	5.6	Binding	Compound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligandCompound was evaluated for in vitro binding affinity towards Dopamine receptor D1 in striatum using [3H]- SCH 23390 as radioligand	ChEMBL	435	6	0	5	4.6	CC1SC(C)(C)C(=O)N1CCCCN1CCN(c2csc3cc(F)ccc23)CC1	10.1021/jm00092a024
		118711255	120730	0	None	-26	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(NCc3cccc(Cl)c3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325905	120730	0	None	-26	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	392	4	2	3	5.3	CN1CCc2cc(NCc3cccc(Cl)c3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		45269964	20393	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1194295	20393	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL550180	20393	0	None	-30	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	309	2	2	3	3.9	CCCN1CCc2cc(C)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		10825256	16950	0	None	-6	3	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	260	0	0	2	3.3	CN1CCc2cccc3c2[C@H]1Cc1cccc(C#N)c1-3	10.1021/jm960189i
		CHEMBL115969	16950	0	None	-6	3	Rat	6.6	pKi	=	6.6	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	260	0	0	2	3.3	CN1CCc2cccc3c2[C@H]1Cc1cccc(C#N)c1-3	10.1021/jm960189i
		44432811	94342	0	None	-5	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	323	3	1	3	4.2	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		CHEMBL233566	94342	0	None	-5	3	Rat	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	323	3	1	3	4.2	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(C)c(O)c1-3	10.1016/j.bmcl.2007.05.057
		44366021	127805	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
		CHEMBL356597	127805	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranesAbility to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 of canine striatal membranes	ChEMBL	420	2	1	3	4.6	CN1CCc2cc(I)c(O)cc2[C@@H](c2ccc(N=[N+]=[N-])cc2)C1	10.1021/jm00164a009
		44415559	86938	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213444	86938	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	496	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415673	146022	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	545	4	1	7	6.1	CCOc1c(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)sc2ccccc12	10.1016/j.bmcl.2006.06.022
		CHEMBL378914	146022	0	None	6	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	545	4	1	7	6.1	CCOc1c(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)sc2ccccc12	10.1016/j.bmcl.2006.06.022
		16104	168696	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		CHEMBL415300	168696	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00067a009
		74223830	136228	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3671305	136228	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
		16104	168696	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		CHEMBL415300	168696	19	None	-1	5	Rat	7.6	pKi	=	7.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(C2=Nc3ccccc3Nc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		17755999	149663	1	None	-5	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		CHEMBL389357	149663	1	None	-5	6	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		86767095	136205	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	345	3	1	5	4.1	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671284	136205	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	345	3	1	5	4.1	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		10566865	122757	0	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL335515	122757	0	None	-4	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	309	6	1	2	4.6	CCCN(CCC)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		44408818	146943	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
		CHEMBL380330	146943	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1021/jm051237e
		44408818	146943	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2006.11.093
		CHEMBL380330	146943	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmcl.2006.11.093
		44408818	146943	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmc.2009.08.028
		CHEMBL380330	146943	1	None	-12	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)CCN(C)CCc1ccccc1C2	10.1016/j.bmc.2009.08.028
		45379370	14295	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1	10.1021/jm901291r
		CHEMBL1087301	14295	0	None	-2	5	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c([nH]c3ccccc23)CC1	10.1021/jm901291r
		10090424	41471	1	None	-3	6	Rat	7.5	pKi	=	7.5	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
		CHEMBL143027	41471	1	None	-3	6	Rat	7.5	pKi	=	7.5	Binding	In vitro affinity against Dopamine receptor D1In vitro affinity against Dopamine receptor D1	ChEMBL	368	3	0	5	4.2	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2occc21	10.1021/jm0009890
		70692656	82850	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2057457	82850	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.12.016
		70692656	82850	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057457	82850	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70692656	82850	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057457	82850	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		70692656	82850	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057457	82850	0	None	5	2	Human	7.5	pKi	=	7.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	309	1	1	3	3.7	COc1cc2c(cc1O)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		44276651	106516	0	None	32	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL284959	106516	0	None	32	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	296	0	3	4	2.7	Cc1cc2c(nc1C)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		15225749	87460	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	341	0	1	5	3.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(N)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL215140	87460	0	None	2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	341	0	1	5	3.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(N)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		137651073	164247	0	None	-53	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4079301	164247	0	None	-53	5	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	405	8	0	7	3.2	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C#N)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		118709162	120185	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	874	20	0	8	10.9	O=C(CCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318834	120185	0	None	-97	4	Pig	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	874	20	0	8	10.9	O=C(CCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		10689581	106939	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL287931	106939	0	None	1	2	Rat	6.6	pKi	=	6.6	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	355	2	3	4	4.4	Oc1cc2c(cc1O)[C@@H]1c3sc(CC4CCCC4)cc3CN[C@H]1CC2	10.1021/jm970038v
		44380770	172491	0	None	-91	4	Bovine	5.6	pKi	=	5.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		CHEMBL424575	172491	0	None	-91	4	Bovine	5.6	pKi	=	5.6	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		11706497	84952	0	None	-776	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
		CHEMBL210461	84952	0	None	-776	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	535	7	1	3	6.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
		56833379	75109	0	None	-234	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1155	37	2	18	8.6	COc1cc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
		CHEMBL1916550	75109	0	None	-234	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1155	37	2	18	8.6	COc1cc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2009919
		44340415	15350	0	None	-3	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL109472	15350	0	None	-3	4	Bovine	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
		127045854	146342	0	None	-218	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3797205	146342	0	None	-218	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		127046949	146687	0	None	-446	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	472	12	3	5	4.6	COc1cc(CCNCCc2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3799455	146687	0	None	-446	6	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	472	12	3	5	4.6	COc1cc(CCNCCc2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		24936042	164368	0	None	-218	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4080762	164368	0	None	-218	5	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	380	8	0	6	3.3	COc1ccccc1N1CCN(CCCCOc2ccn3nccc3c2)CC1	10.1021/acs.jmedchem.6b01857
		57390115	76071	0	None	-575	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.4	CCOCCOc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928120	76071	0	None	-575	5	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.4	CCOCCOc1cccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)c1	10.1016/j.bmc.2011.10.063
		24824065	104727	0	None	-1	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
		CHEMBL272602	104727	0	None	-1	4	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccccc1N1CCN(Cc2cnn3ccccc23)CC1	10.1021/jm701375u
		10404144	212081	23	None	-2187	10	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		CHEMBL7927	212081	23	None	-2187	10	Pig	5.6	pKi	=	5.6	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		14198593	205453	1	None	4	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		CHEMBL57988	205453	1	None	4	2	Rat	6.6	pKi	=	6.6	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		14198594	206882	1	None	6	2	Human	6.6	pKi	=	6.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNC[C@H]2c1ccccc1	10.1021/jm00129a006
		CHEMBL59603	206882	1	None	6	2	Human	6.6	pKi	=	6.6	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNC[C@H]2c1ccccc1	10.1021/jm00129a006
		44582178	188038	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	378	6	0	4	3.1	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476185	188038	0	None	-1	3	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	378	6	0	4	3.1	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ccccn2)CC1	10.1016/j.bmcl.2009.01.067
		9951008	213176	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL87717	213176	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm981094e
		9951008	213176	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm00042a009
		CHEMBL87717	213176	0	None	-39	4	Rat	5.6	pKi	=	5.6	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	365	5	0	3	4.2	O=C(c1ccc(F)cc1)C1CCN(CCC2Cc3ccccc3C2=O)CC1	10.1021/jm00042a009
		3561	25849	39	None	-1	11	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		CHEMBL1289	25849	39	None	-1	11	Human	6.6	pKi	=	6.6	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	nan
		15711852	20111	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL1192193	20111	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL543389	20111	0	None	-6	3	Rat	5.6	pKi	=	5.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		5041	10067	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
		981	10067	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
		CHEMBL4096543	10067	6	None	-11220	6	Human	5.6	pKi	=	5.6	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	465	6	0	4	4.6	CC(Oc1cccnc1N(C1CCN(CC1)Cc1ccc(cc1)I)C)C	10.1021/acs.jmedchem.7b00151
		15711851	20312	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		CHEMBL1193797	20312	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		CHEMBL545264	20312	0	None	-2	3	Rat	6.6	pKi	=	6.6	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	303	3	1	3	3.8	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN(C)C	10.1021/jm00114a002
		14198586	208612	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		CHEMBL60706	208612	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		91899758	136219	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cc(=O)[nH]nc1C	nan
		CHEMBL3671297	136219	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1cc(=O)[nH]nc1C	nan
		117773787	139219	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.7	Cc1cc(Oc2ncccc2C2COC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697582	139219	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.7	Cc1cc(Oc2ncccc2C2COC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		10333195	54960	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
		CHEMBL155208	54960	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
		1353	8692	93	None	-74	85	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		3559	8692	93	None	-74	85	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		86	8692	93	None	-74	85	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		CHEMBL54	8692	93	None	-74	85	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		DB00502	8692	93	None	-74	85	Rat	7.5	pKi	=	7.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm020938y
		103	10925	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		2875	10925	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		5736	10925	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		CHEMBL285802	10925	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		DB09225	10925	61	None	-28	53	Human	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm0002432
		10379766	11678	0	None	14	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.2	CCc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
		CHEMBL104571	11678	0	None	14	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	295	1	3	3	3.2	CCc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
		17755999	149663	1	None	-5	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1021/jm070388+
		CHEMBL389357	149663	1	None	-5	6	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	1	0	2	3.7	COc1ccc2c(c1)CCCN(C)CCc1ccccc1C2	10.1021/jm070388+
		86767097	136207	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	359	3	1	5	4.5	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671286	136207	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	359	3	1	5	4.5	Cc1ncc2nccn2c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		135398737	7745	93	None	-44	90	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		38	7745	93	None	-44	90	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		722	7745	93	None	-44	90	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		CHEMBL42	7745	93	None	-44	90	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		DB00363	7745	93	None	-44	90	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2008.06.030
		10472143	126055	0	None	-645	16	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL343755	126055	0	None	-645	16	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@H]1C[C@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		11777127	32582	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL135318	32582	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		228	7233	28	None	-35	23	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		33	7233	28	None	-35	23	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		6005	7233	28	None	-35	23	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		CHEMBL53	7233	28	None	-35	23	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		DB00714	7233	28	None	-35	23	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2008.05.077
		10154	148907	59	None	-58	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		CHEMBL388342	148907	59	None	-58	4	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	327	2	2	5	2.9	COc1cc2c(cc1O)C[C@H]1c3c(cc(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		9980998	37808	0	None	-1819	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
		CHEMBL139926	37808	0	None	-1819	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
		CHEMBL2112911	37808	0	None	-1819	7	Human	5.5	pKi	=	5.5	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2o1	10.1021/jm025558r
		11697270	84085	0	None	-3467	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	412	5	0	5	4.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1	10.1021/jm060166w
		CHEMBL208274	84085	0	None	-3467	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	412	5	0	5	4.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1	10.1021/jm060166w
		44340376	117423	0	None	-24	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL325818	117423	0	None	-24	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	6	1	3	4.9	COc1c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		25256816	188387	0	None	-4466	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL477206	188387	0	None	-4466	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	407	7	0	4	3.7	COc1ccccc1N1CCN(CCCCN2CCCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		16754	92349	50	None	-67	7	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL228082	92349	50	None	-67	7	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	355	4	0	5	3.5	COc1cc2c(cc1OC)-c1c(OC)c(OC)cc3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		25139181	191121	0	None	-1513	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
		CHEMBL484358	191121	0	None	-1513	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	414	10	1	2	5.7	C#CC1=CCC(N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm800895v
		44567587	185014	0	None	-66	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	311	2	2	4	3.2	CCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		CHEMBL465055	185014	0	None	-66	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	311	2	2	4	3.2	CCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		127046951	146680	0	None	-61	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3799427	146680	0	None	-61	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		137633705	163397	0	None	-5370	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	474	7	2	7	4.0	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1	10.1021/acs.jmedchem.6b01857
		CHEMBL4069091	163397	0	None	-5370	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	474	7	2	7	4.0	O=C(CCCN1CCN(c2cccc(Cl)c2Cl)CC1)Nc1ccn2ncc(/C=N\O)c2c1	10.1021/acs.jmedchem.6b01857
		122177645	127991	0	None	-13803	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
		CHEMBL3577346	127991	0	None	-13803	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	591	18	2	8	5.6	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)[C@H]3CCc4c(O)cccc4C3)cc2OC)nn1	10.1021/jm501889t
		57391897	76084	0	None	-301	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	481	12	1	8	2.7	CCOCCOc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928133	76084	0	None	-301	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	481	12	1	8	2.7	CCOCCOc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		57393634	76094	0	None	-26	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1cc(COCCOCCOCCOCCOCc2ccc(N3CCN(CCCCNC(=O)c4ccccc4)CC3)c(OC)c2)ccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928248	76094	0	None	-26	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1cc(COCCOCCOCCOCCOCc2ccc(N3CCN(CCCCNC(=O)c4ccccc4)CC3)c(OC)c2)ccc1N1CCN(CCCCNC(=O)c2ccccc2)CC1	10.1016/j.bmc.2011.10.063
		24824063	104777	11	None	-5	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cc4ccccn4n3)CC2)cc1	10.1021/jm701375u
		CHEMBL272853	104777	11	None	-5	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cc4ccccn4n3)CC2)cc1	10.1021/jm701375u
		44381216	127110	0	None	-19054	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
		CHEMBL352925	127110	0	None	-19054	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
		44329314	214721	0	None	-69	3	Bovine	4.5	pKi	=	4.5	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL96958	214721	0	None	-69	3	Bovine	4.5	pKi	=	4.5	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2c(C)ccc2C1	10.1016/s0960-894x(01)00564-9
		154706546	183225	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4452329	183225	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596339	183225	1	None	-63	4	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(F)c1	10.1021/acs.jmedchem.9b01835
		17755991	159077	0	None	1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	267	0	2	2	3.1	Oc1ccc2c(c1)CCCNCCc1ccccc1C2	10.1021/jm070388+
		CHEMBL396950	159077	0	None	1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	267	0	2	2	3.1	Oc1ccc2c(c1)CCCNCCc1ccccc1C2	10.1021/jm070388+
		96918	19262	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
		CHEMBL1186488	19262	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
		118711257	120732	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccccc1CNc1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
		CHEMBL3325907	120732	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccccc1CNc1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
		44568534	181095	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	265	0	2	3	2.6	CN1CCc2cc(N)cc3c2[C@H]1Cc1cccc(N)c1-3	10.1016/j.bmc.2008.05.077
		CHEMBL455051	181095	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	265	0	2	3	2.6	CN1CCc2cc(N)cc3c2[C@H]1Cc1cccc(N)c1-3	10.1016/j.bmc.2008.05.077
		10438027	72962	0	None	-954	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
		CHEMBL184383	72962	0	None	-954	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1021/jm900095y
		44415805	88310	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	561	4	1	5	7.1	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(CC3CCCCC3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL216047	88310	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	561	4	1	5	7.1	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(CC3CCCCC3)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		96918	19262	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
		CHEMBL1186488	19262	30	None	-8	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	309	5	0	3	4.1	COc1cc(CCN(C)C)c2ccc3ccccc3c2c1OC	10.1016/j.bmcl.2013.06.078
		154704705	183104	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4590356	183104	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4595409	183104	1	None	-1	5	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	11	1	6	4.9	CCOc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		10367486	16066	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL110948	16066	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		CHEMBL543613	16066	1	None	-6	4	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	398	4	0	5	5.0	O=C1c2ccsc2CCC1CCN1CCC(c2noc3cc(F)ccc23)CC1	10.1021/jm981094e
		1042	8362	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		148	8362	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		443884	8362	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		CHEMBL119443	8362	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		DB01253	8362	23	None	-204	17	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	nan
		72708126	98977	0	None	-7	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425375	98977	0	None	-7	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		71450550	90582	0	None	-6	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to D1 dopamine receptorBinding affinity to D1 dopamine receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		CHEMBL2205836	90582	0	None	-6	16	Human	5.5	pKi	=	5.5	Binding	Binding affinity to D1 dopamine receptorBinding affinity to D1 dopamine receptor	ChEMBL	309	4	1	3	2.0	COc1ccccc1CCN1C2C3C4CC5C6C4C2C6C1(O)C53	10.1016/j.bmcl.2012.08.046
		736083	168993	17	None	-50	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL416288	168993	17	None	-50	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	267	0	2	3	2.9	CN1CCc2cccc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		10452020	125053	3	None	10	3	Human	8.5	pKi	=	8.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm9800292
		CHEMBL34095	125053	3	None	10	3	Human	8.5	pKi	=	8.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)[C@@H](c2ccccc2)C1	10.1021/jm9800292
		10516818	32423	0	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135197	32423	0	None	2	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	279	4	1	2	3.6	C=CCN(C)[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		122324	6993	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
		6077	6993	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
		CHEMBL86931	6993	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00114a002
		10467946	55243	4	None	-1	4	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
		CHEMBL155596	55243	4	None	-1	4	Bovine	8.5	pKi	=	8.5	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	263	5	2	3	3.1	CCCN(CCC)[C@H]1CCc2c(ccc(O)c2O)C1	10.1021/jm020990u
		14809027	113806	0	None	257	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL315468	113806	0	None	257	4	Rat	8.5	pKi	=	8.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@@H]1OC(c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		122324	6993	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		6077	6993	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		CHEMBL86931	6993	22	None	323	3	Rat	8.5	pKi	=	8.5	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	10.1021/jm00173a005
		44415690	86912	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL213336	86912	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		44415690	86912	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL213336	86912	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	2	1	5	5.1	Cc1cccc(C)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		44415506	87014	0	None	169	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		CHEMBL213793	87014	0	None	169	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)c1	10.1016/j.bmcl.2006.06.022
		46231845	207512	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	391	0	1	2	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL600083	207512	0	None	2	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	391	0	1	2	4.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(Br)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		1153	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		12668023	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		30026874	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		30026875	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		3341	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		6603851	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		933	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		939	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		985	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		CHEMBL1160786	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		CHEMBL1161520	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		CHEMBL588	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		DB00800	8409	58	None	-1	10	Rat	8.5	pKi	=	8.5	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm00160a018
		44401164	76591	0	None	-19	9	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	76591	0	None	-19	9	Human	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		11573628	81474	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
		CHEMBL203047	81474	0	None	-1	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	301	0	1	2	3.7	CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1	10.1021/jm051237e
		46231848	207317	0	None	8	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	396	1	1	3	4.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL598949	207317	0	None	8	4	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	396	1	1	3	4.1	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(N4CCCC4=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		3038603	108642	8	None	2	3	Human	8.5	pKi	=	8.5	Binding	The compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligandThe compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligand	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
		CHEMBL300647	108642	8	None	2	3	Human	8.5	pKi	=	8.5	Binding	The compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligandThe compound was tested for binding affinity against Dopamine receptor D1 using SCH-23390 as radioligand	ChEMBL	335	1	0	1	5.4	CN(C)C1C=CC2(CC1)c1ccccc1C=Cc1ccc(Cl)cc12	10.1021/jm00109a026
		86763997	139251	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697613	139251	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		11778580	72901	1	None	-5	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	0	1	3	2.9	CN1CCOc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm049720x
		CHEMBL184050	72901	1	None	-5	5	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	283	0	1	3	2.9	CN1CCOc2cc(O)ccc2Cc2ccccc2CC1	10.1021/jm049720x
		11493746	148101	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
		CHEMBL383451	148101	0	None	-2	3	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	335	0	1	2	4.3	CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1	10.1021/jm051237e
		17755867	92884	1	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
		CHEMBL231070	92884	1	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2ccc(O)cc2CC1	10.1021/jm070388+
		44415704	86934	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL213424	86934	0	None	-1	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	474	2	2	6	4.4	Cc1cccc(N)c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		15937717	27419	0	None	346	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	253	2	1	2	3.4	CCCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL130851	27419	0	None	346	2	Rat	8.5	pKi	=	8.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	253	2	1	2	3.4	CCCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		56944383	118896	0	None	-6	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		CHEMBL3290012	118896	0	None	-6	12	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cellsDisplacement of [3H]SCH23390 from human recombinant D1 receptor expressed in CHO cells	ChEMBL	487	8	1	6	5.1	O=S(=O)(NCCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2ccccc2s1	10.1021/jm401895u
		9861622	206223	5	None	1202	2	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	10.1021/jm00128a038
		CHEMBL59139	206223	5	None	1202	2	Rat	8.5	pKi	=	8.5	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	10.1021/jm00128a038
		44415723	148558	0	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL386122	148558	0	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		6917970	10463	61	None	-1	33	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
		8370	10463	61	None	-1	33	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
		CHEMBL487387	10463	61	None	-1	33	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.12.016
		11079319	138578	1	None	-7	2	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	1	0	4	3.9	CN1CCN(C2=Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm0309811
		CHEMBL369367	138578	1	None	-7	2	Rat	8.5	pKi	=	8.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	1	0	4	3.9	CN1CCN(C2=Cn3cccc3Sc3ccc(Br)cc32)CC1	10.1021/jm0309811
		5249956	80170	1	None	-4	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL201525	80170	1	None	-4	6	Human	8.5	pKi	=	8.5	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2008.04.081
		44415536	145408	0	None	95	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(I)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL377584	145408	0	None	95	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(I)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		117774127	139201	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697564	139201	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		142405812	187782	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	381	3	1	4	5.6	CCOc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4758966	187782	0	None	-40	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	381	3	1	4	5.6	CCOc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1cc(Cl)ccc1N2	10.1016/j.bmcl.2020.127563
		15937730	25723	0	None	478	2	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	301	1	1	2	3.9	CN1CCc2cc(Cl)c(O)cc2C(C2C=CC=CC=C2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL128649	25723	0	None	478	2	Rat	8.4	pKi	=	8.4	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	301	1	1	2	3.9	CN1CCc2cc(Cl)c(O)cc2C(C2C=CC=CC=C2)C1	10.1016/S0960-894X(00)80155-9
		44439945	100142	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL245571	100142	0	None	1	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	306	0	2	2	3.5	CN1CCc2cc(O)ccc2Cc2[nH]c3ccccc3c2CC1	10.1016/j.bmcl.2006.11.093
		71474025	152105	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3913343	152105	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		71474025	152105	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3913343	152105	0	None	131	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		44561317	195753	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	1	2	3.4	CCN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		CHEMBL508399	195753	0	None	1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	281	1	1	2	3.4	CCN1CCc2ccccc2Cc2ccc(O)cc2CC1	10.1016/j.bmcl.2008.04.081
		44415593	87022	0	None	-3	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213834	87022	0	None	-3	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc4ccccc34)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		6603703	6996	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
		9637	6996	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
		CHEMBL291143	6996	10	None	1	5	Pig	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysisDisplacement of [3H]SCH-23390 from porcine striatum dopamine D1 receptor incubated for 30 mins by radioligand competition binding assay based scintillation counter analysis	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1016/j.ejmech.2020.113073
		12668019	17011	8	None	204	3	Human	7.5	pKi	=	7.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/jm9800292
		CHEMBL1160787	17011	8	None	204	3	Human	7.5	pKi	=	7.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1cc2c(c(Cl)c1O)CCNC[C@@H]2c1ccccc1	10.1021/jm9800292
		44415338	162535	0	None	69	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	579	3	1	7	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnn(-c4ccccc4)c3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL405751	162535	0	None	69	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	579	3	1	7	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cnn(-c4ccccc4)c3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		6603703	6996	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
		9637	6996	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
		CHEMBL291143	6996	10	None	-7	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	10.1021/jm970038v
		74223723	136193	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	334	3	1	4	4.6	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671272	136193	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	334	3	1	4	4.6	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		44320378	212842	0	None	25	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL85409	212842	0	None	25	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	3	3	4	2.6	NC[C@@H]1OC(CC2CCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		86764212	139226	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	4	4.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697589	139226	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	4	4.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		9949441	121239	0	None	-7	4	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL333455	121239	0	None	-7	4	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		53364155	70618	0	None	-27	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1041	33	0	16	10.2	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCCc1cn(CCCCCCCCCCn2cc(CCCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803026	70618	0	None	-27	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	1041	33	0	16	10.2	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCCc1cn(CCCCCCCCCCn2cc(CCCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		71733932	97827	0	None	-416	6	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
		CHEMBL2397389	97827	0	None	-416	6	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	414	10	1	2	5.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm400520c
		145988693	173945	0	None	-12	17	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL4291048	173945	0	None	-12	17	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	524	7	1	3	7.1	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCN(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		10310103	114089	0	None	-776	9	Rat	5.5	pKi	=	5.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	425	5	0	5	5.3	N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
		CHEMBL317333	114089	0	None	-776	9	Rat	5.5	pKi	=	5.5	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	425	5	0	5	5.3	N#CCCN1CCC(c2cn(-c3ccc(F)cc3)c3ccc(-c4ncccn4)cc23)CC1	10.1021/jm020938y
		3038495	7495	37	None	-2041	18	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		7625	7495	37	None	-2041	18	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		CHEMBL25236	7495	37	None	-2041	18	Rat	5.5	pKi	=	5.5	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm0211220
		44436600	98577	0	None	-3019	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL241212	98577	0	None	-3019	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	391	8	1	4	3.0	C#Cc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2007.08.038
		44340227	117418	0	None	-2137	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL325772	117418	0	None	-2137	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
		10663221	40487	1	None	-60	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1	10.1021/jm0009989
		CHEMBL142217	40487	1	None	-60	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4)CC3)c2c1	10.1021/jm0009989
		11983282	145721	0	None	-5128	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
		CHEMBL378455	145721	0	None	-5128	6	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	315	4	0	3	4.2	C1=C(c2ccccc2)CCN(Cc2cnn(-c3ccccc3)c2)C1	10.1016/j.bmcl.2006.02.075
		10333195	54960	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
		CHEMBL155208	54960	0	None	-10	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
		25128757	110081	0	None	-831	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	383	3	1	3	5.6	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12	10.1021/jm800532x
		CHEMBL3084512	110081	0	None	-831	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	383	3	1	3	5.6	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1csc2ccccc12	10.1021/jm800532x
		44448058	161983	0	None	2	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL402517	161983	0	None	2	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		72545007	99897	0	None	-199	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	407	12	0	8	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443000	99897	0	None	-199	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	407	12	0	8	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		24824060	162494	0	None	-12	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
		CHEMBL405292	162494	0	None	-12	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cc4ccccn4n3)CC2)n1	10.1021/jm701375u
		10404663	173640	10	None	-1000	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	334	9	1	3	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)ccc1OC	10.1016/j.bmc.2007.07.017
		CHEMBL428561	173640	10	None	-1000	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	334	9	1	3	3.0	C=CCN1CCC[C@H]1CNC(=O)c1cc(CCCF)ccc1OC	10.1016/j.bmc.2007.07.017
		12050198	207033	0	None	-87	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	347	6	1	4	4.1	c1ccc(CN2CCC(NCc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL59702	207033	0	None	-87	4	Bovine	4.5	pKi	=	4.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	347	6	1	4	4.1	c1ccc(CN2CCC(NCc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		156012196	184111	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	296	1	2	4	2.7	COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4637246	184111	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	296	1	2	4	2.7	COc1cc2c3c(c1O)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		46227242	206709	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	2	1	2	3.5	Cc1ccccc1CC1c2ccc(O)cc2CCN1C	10.1016/j.bmc.2009.08.028
		CHEMBL594798	206709	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	2	1	2	3.5	Cc1ccccc1CC1c2ccc(O)cc2CCN1C	10.1016/j.bmc.2009.08.028
		10809507	126462	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(OC)cc(Br)c2C1Cc1ccccc1O	10.1021/jm991034o
		CHEMBL347243	126462	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(OC)cc(Br)c2C1Cc1ccccc1O	10.1021/jm991034o
		76314268	113211	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3115577	113211	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3139633	113211	0	None	-2630	4	Human	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		188249	46427	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		CHEMBL147463	46427	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		CHEMBL2022280	46427	4	None	-2	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	328	0	0	5	3.2	CN1CCN(C2=Nc3cc(Cl)ccc3Oc3ncccc32)CC1	10.1021/jm00030a011
		15654862	210430	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ccncc32)CC1	10.1021/jm00067a009
		CHEMBL67298	210430	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ccncc32)CC1	10.1021/jm00067a009
		15654863	210216	0	None	7	2	Rat	5.5	pKi	=	5.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ccncc32)CC1	10.1021/jm00067a009
		CHEMBL65768	210216	0	None	7	2	Rat	5.5	pKi	=	5.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ccncc32)CC1	10.1021/jm00067a009
		15654861	107518	0	None	3	2	Rat	4.5	pKi	=	4.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ncccc32)CC1	10.1021/jm00067a009
		CHEMBL292738	107518	0	None	3	2	Rat	4.5	pKi	=	4.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3ccccc3N(C=O)c3ncccc32)CC1	10.1021/jm00067a009
		44591099	182969	0	None	-1122	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL459350	182969	0	None	-1122	6	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		9796958	153356	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL2115374	153356	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL39230	153356	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL544814	153356	0	None	-28	4	Human	5.5	pKi	=	5.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm00018a002
		CHEMBL3215298	218010	13	None	-6	2	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL		None	None	None		CC[C@H](C)[C@H]1O[C@]2(C=C[C@@H]1C)C[C@@H]1C[C@@H](C/C=C(\C)[C@@H](O[C@H]3C[C@H](OC)[C@@H](O[C@H]4C[C@H](OC)[C@@H](O)[C@H](C)O4)[C@H](C)O3)[C@@H](C)/C=C/C=C3\CO[C@@H]4[C@H](O)C(C)=C[C@@H](C(=O)O1)[C@]34O)O2.CO[C@H]1C[C@H](O[C@H]2[C@H](C)O[C@@H](O[C@@H]3/C(C)=C/C[C@@H]4C[C@@H](C[C@]5(C=C[C@H](C)[C@@H](C(C)C)O5)O4)OC(=O)[C@@H]4C=C(C)[C@@H](O)[C@H]5OC/C(=C\C=C\[C@@H]3C)[C@@]45O)C[C@@H]2OC)O[C@@H](C)[C@@H]1O	nan
		681	8247	72	None	-97	38	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		940	8247	72	None	-97	38	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		947	8247	72	None	-97	38	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		CHEMBL59	8247	72	None	-97	38	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		DB00988	8247	72	None	-97	38	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/0960-894X(95)00413-N
		10474964	137249	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL368061	137249	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		CHEMBL5206021	137249	0	None	-8511	7	Bovine	5.5	pKi	=	5.5	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	381	5	1	3	3.3	O=C(NCCN1CCN(C2CCCc3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm950759z
		10693836	16109	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL111189	16109	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL545488	16109	0	None	-19	4	Rat	5.5	pKi	=	5.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	428	8	0	5	4.3	O=C(CCCN1CCN(CCC2CCc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		44579031	196614	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	391	8	0	3	6.1	CCCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		CHEMBL516580	196614	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	391	8	0	3	6.1	CCCCCCC(=O)Oc1cccc2c1-c1cccc3c1[C@@H](C2)N(CCC)CC3	10.1016/j.bmc.2008.08.056
		44415835	146572	0	None	181	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		CHEMBL379875	146572	0	None	181	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	5	1	8	4.5	COc1cc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc(OC)c1OC	10.1016/j.bmcl.2006.06.034
		45271622	20803	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1197278	20803	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL564909	20803	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	357	2	2	3	4.9	CCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		134147903	156206	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	383	6	2	5	4.3	CCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3945856	156206	0	None	-1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	383	6	2	5	4.3	CCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		9949441	121239	0	None	-7	4	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL333455	121239	0	None	-7	4	Rat	7.5	pKi	=	7.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	331	2	0	4	3.5	CCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		117774096	139208	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	5	3.7	Cc1cc(Oc2ncccc2C(C)C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697571	139208	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	5	3.7	Cc1cc(Oc2ncccc2C(C)C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		135398737	7745	93	None	-44	90	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		38	7745	93	None	-44	90	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		722	7745	93	None	-44	90	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		CHEMBL42	7745	93	None	-44	90	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		DB00363	7745	93	None	-44	90	Human	7.5	pKi	=	7.5	Binding	Binding affinity against Dopamine D1 receptorBinding affinity against Dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2004.06.005
		64638	112918	2	None	40	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL313530	112918	2	None	40	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	329	2	3	4	3.3	NC[C@@H]1OC(C23C[C@H]4C[C@@H](C2)C[C@@H](C3)C4)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44320053	212552	0	None	257	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL82899	212552	0	None	257	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	1	3	4	2.1	CC(C)(C)C1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		44319976	113740	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
		CHEMBL315005	113740	0	None	2	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	3	3	5	2.4	COc1cccc(C2Cc3c(ccc(O)c3O)[C@H](CN)O2)c1	10.1021/jm00112a034
		11186895	94282	25	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
		CHEMBL2334885	94282	25	None	-5	4	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3OC)C[C@@H]21	10.1016/j.bmc.2012.12.016
		242	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		34	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		60795	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		CHEMBL1112	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		DB01238	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1016/j.bmc.2017.08.037
		242	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		34	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		60795	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		CHEMBL1112	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		DB01238	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		242	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		34	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		60795	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		CHEMBL1112	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		DB01238	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.6b01857
		242	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		34	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		60795	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		CHEMBL1112	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		DB01238	7258	124	None	-281	51	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/jm5004039
		44436599	98576	0	None	-257	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL241211	98576	0	None	-257	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(C#Cc2ccccc2)c1	10.1016/j.bmc.2007.08.038
		136043855	148306	0	None	-389	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	482	2	1	6	5.6	FC1(F)Oc2cccc(CN3CCN(C4=Nc5cc(Cl)ccc5Nc5ccccc54)CC3)c2O1	10.1016/j.bmcl.2006.06.034
		CHEMBL384634	148306	0	None	-389	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	482	2	1	6	5.6	FC1(F)Oc2cccc(CN3CCN(C4=Nc5cc(Cl)ccc5Nc5ccccc54)CC3)c2O1	10.1016/j.bmcl.2006.06.034
		127031949	145533	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	317	7	2	5	2.8	COc1cc(CCN(C)Cc2cccc(O)c2OC)ccc1O	10.1016/j.bmc.2016.03.037
		CHEMBL3780438	145533	0	None	-1	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	317	7	2	5	2.8	COc1cc(CCN(C)Cc2cccc(O)c2OC)ccc1O	10.1016/j.bmc.2016.03.037
		4189	213701	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL1559	213701	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		CHEMBL91	213701	96	None	-25	34	Human	5.5	pKi	=	5.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	nan
		117773625	139191	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.4	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2)c(C)c(=O)[nH]c1=O	nan
		CHEMBL3697554	139191	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.4	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2)c(C)c(=O)[nH]c1=O	nan
		44319988	212858	0	None	3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL85552	212858	0	None	3	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	335	6	4	5	2.6	OCCCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		156012433	184093	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	326	2	1	5	3.1	COc1cc2c3c(c1O)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4636948	184093	0	None	1	4	Human	6.5	pKi	=	6.5	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	326	2	1	5	3.1	COc1cc2c3c(c1O)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		1353	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		3559	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		86	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		CHEMBL54	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		DB00502	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		135398737	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		38	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		722	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		CHEMBL42	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		DB00363	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		3246545	209253	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL1573438	209253	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL611207	209253	1	None	-7	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		1353	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		3559	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		86	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		CHEMBL54	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		DB00502	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting methodBinding affinity to dopamine D1 receptor in rat striatum by liquid scintillation counting method	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/acs.jmedchem.7b01584
		1353	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		3559	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		86	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		CHEMBL54	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		DB00502	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm800689g
		1353	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		3559	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		86	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		CHEMBL54	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		DB00502	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm010982y
		1353	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		3559	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		86	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		CHEMBL54	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		DB00502	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm0309811
		1353	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		3559	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		86	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		CHEMBL54	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		DB00502	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049629t
		44319915	212744	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL84557	212744	0	None	-1	2	Rat	5.5	pKi	=	5.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	331	5	2	4	3.8	C=CCN(C)C[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44415848	86684	0	None	40	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212438	86684	0	None	40	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	517	2	1	5	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		134150852	158474	0	None	12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	461	6	2	5	5.1	CCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3964242	158474	0	None	12	3	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	461	6	2	5	5.1	CCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		86764320	139247	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697609	139247	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		15711869	20112	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL1192194	20112	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL543390	20112	0	None	-6	6	Goldfish	7.5	pKi	=	7.5	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		6852376	98374	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
		CHEMBL1467585	98374	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
		CHEMBL24077	98374	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
		CHEMBL503958	98374	13	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm9800292
		71109986	157412	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
		CHEMBL3955446	157412	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3cc(OC)c(OC)c(OC)c3CN1CC2	nan
		54585811	68384	0	None	-2454	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	418	7	0	5	3.2	COc1ccccc1N1CCN(CCCCN2CCc3cc(C#N)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771113	68384	0	None	-2454	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	418	7	0	5	3.2	COc1ccccc1N1CCN(CCCCN2CCc3cc(C#N)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		49783042	24463	0	None	-112	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	1	3	4.3	Cc1ccc(C)c(C(=O)NCCCCN2CCN(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		CHEMBL1258495	24463	0	None	-112	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	393	7	1	3	4.3	Cc1ccc(C)c(C(=O)NCCCCN2CCN(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		10871118	213586	0	None	-489	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccn4nccc34)CC2)cc1	10.1021/jm015522j
		CHEMBL90374	213586	0	None	-489	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cccn4nccc34)CC2)cc1	10.1021/jm015522j
		10667043	35322	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	7	2	3	4.6	NCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL137637	35322	0	None	7	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	7	2	3	4.6	NCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		44537929	204859	0	None	-53	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(O)c(Cl)cc21	10.1016/j.bmc.2009.05.079
		CHEMBL574296	204859	0	None	-53	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	239	3	2	2	3.4	CCCCC1NCCc2cc(O)c(Cl)cc21	10.1016/j.bmc.2009.05.079
		2470	10425	50	None	-4168	58	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		3300	10425	50	None	-4168	58	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		5265	10425	50	None	-4168	58	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		99	10425	50	None	-4168	58	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		CHEMBL267930	10425	50	None	-4168	58	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	10.1021/jm00115a012
		15021876	110187	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm00111a046
		CHEMBL308480	110187	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm00111a046
		15021876	110187	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm981094e
		CHEMBL308480	110187	0	None	-60	6	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	365	4	0	3	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2ccccc21	10.1021/jm981094e
		10093238	214396	0	None	-1	3	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	414	8	0	5	3.9	O=C(CCCN1CCN(CCC2Cc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL95112	214396	0	None	-1	3	Rat	6.5	pKi	=	6.5	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	414	8	0	5	3.9	O=C(CCCN1CCN(CCC2Cc3sccc3C2=O)CC1)c1ccc(F)cc1	10.1021/jm981094e
		10738913	211742	0	None	-5	5	Rat	4.5	pKi	=	4.5	Binding	Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.	ChEMBL	386	8	2	5	1.5	CCOC(=O)c1[nH]c2ccc(CCN3C(=O)CNC3=O)cc2c1CCN(C)C	10.1021/jm9605849
		CHEMBL76480	211742	0	None	-5	5	Rat	4.5	pKi	=	4.5	Binding	Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.Affinity pKi for Dopamine receptor D1 was measured in rat cortex homogenates.	ChEMBL	386	8	2	5	1.5	CCOC(=O)c1[nH]c2ccc(CCN3C(=O)CNC3=O)cc2c1CCN(C)C	10.1021/jm9605849
		73356845	98979	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425377	98979	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		235224	134933	29	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
		CHEMBL36654	134933	29	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
		45481864	204913	0	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	2	2	3.5	Oc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL574695	204913	0	None	-4	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	2	2	3.5	Oc1cc2c(cc1Cl)CCNC2Cc1ccccc1	10.1016/j.bmc.2009.05.079
		2402	10143	62	None	-61	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		5095	10143	62	None	-61	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		7295	10143	62	None	-61	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		CHEMBL589	10143	62	None	-61	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		DB00268	10143	62	None	-61	24	Human	4.5	pKi	=	4.5	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	10.1039/C4MD00066H
		44320328	213007	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
		CHEMBL86669	213007	0	None	1	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	317	4	3	4	3.4	Oc1ccc2c(c1O)CC(C1CCCCC1)O[C@H]2CNC1CC1	10.1021/jm00112a034
		11696813	194697	12	None	-316	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
		CHEMBL496739	194697	12	None	-316	9	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	10.1021/jm800689g
		73356845	98979	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425377	98979	0	None	-4	2	Rat	4.5	pKi	=	4.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1ccc2c(c1)CC1c3cc4c(cc3CCN1C2)OCO4	10.1016/j.ejmech.2013.07.036
		6603820	102549	19	None	-4	12	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
		CHEMBL25856	102549	19	None	-4	12	Human	7.5	pKi	=	7.5	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1021/jm00018a002
		6603820	102549	19	None	-4	12	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL25856	102549	19	None	-4	12	Human	7.5	pKi	=	7.5	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		15937720	123652	0	None	81	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	271	2	1	3	3.3	CCSC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL338237	123652	0	None	81	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	271	2	1	3	3.3	CCSC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		86763999	139254	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.5	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2C)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697616	139254	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.5	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2C)n(C)c(=O)[nH]c1=O	nan
		45483269	203738	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	426	4	0	7	4.1	CSc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
		CHEMBL566508	203738	0	None	-7	4	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	426	4	0	7	4.1	CSc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
		44396220	132201	1	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	2	4.1	c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1	10.1021/jm049720x
		CHEMBL364565	132201	1	None	-1	6	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	295	6	0	2	4.1	c1ccc(Cc2ccccc2OCCN2CCCCC2)cc1	10.1021/jm049720x
		90666899	116222	0	None	-6	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	381	3	1	4	4.2	Cc1nc2c(o1)CC(CN1CCC(c3c[nH]c4cc(F)ccc34)CC1)CC2=O	10.1039/C1MD00202C
		CHEMBL3220215	116222	0	None	-6	7	Human	7.5	pKi	=	7.5	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	381	3	1	4	4.2	Cc1nc2c(o1)CC(CN1CCC(c3c[nH]c4cc(F)ccc34)CC1)CC2=O	10.1039/C1MD00202C
		2865	10915	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		59	10915	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		60854	10915	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		CHEMBL708	10915	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		DB00246	10915	73	None	-114	53	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm030480f
		511482	104027	6	None	-251	5	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	325	3	1	2	4.1	Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL268799	104027	6	None	-251	5	Bovine	6.5	pKi	=	6.5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	325	3	1	2	4.1	Clc1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		46917637	75107	0	None	-275	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1053	34	1	15	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(CN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		CHEMBL1916548	75107	0	None	-275	4	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1053	34	1	15	9.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(CN5CCN(c6ccccc6OC)CC5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		44417647	88936	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
		CHEMBL1203924	88936	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
		CHEMBL216945	88936	0	None	1	2	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	311	2	2	4	3.2	CCCN1Cc2ccccc2C2c3cc(O)c(O)cc3OCC21	10.1021/jm0604979
		44400519	139907	0	None	-549	5	Pig	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL370297	139907	0	None	-549	5	Pig	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		10438027	72962	0	None	-1096	6	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1016/j.bmcl.2004.05.052
		CHEMBL184383	72962	0	None	-1096	6	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	571	7	1	4	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2cc(I)ccc2o1	10.1016/j.bmcl.2004.05.052
		44381147	65503	0	None	-93	4	Bovine	5.5	pKi	=	5.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		CHEMBL168544	65503	0	None	-93	4	Bovine	5.5	pKi	=	5.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@@H]1CN(Cc2ccccc2)C[C@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		44340415	15350	0	None	-3	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL109472	15350	0	None	-3	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	460	5	1	3	5.3	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(C#Cc2ccccc2)c2ccccc12	10.1016/s0960-894x(03)00678-4
		44340333	16434	0	None	-1071	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL112833	16434	0	None	-1071	4	Bovine	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
		122181330	128649	0	None	-3890	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		CHEMBL3590081	128649	0	None	-3890	6	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes	ChEMBL	396	9	1	3	5.3	CCCN(CCCCNC(=O)/N=N/c1ccc(F)cc1)C1Cc2ccccc2C1	10.1016/j.bmc.2014.12.012
		44372153	126942	0	None	-89	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	416	4	0	4	5.3	Cc1nn2c(-c3ccccc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		CHEMBL351550	126942	0	None	-89	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	416	4	0	4	5.3	Cc1nn2c(-c3ccccc3)cccc2c1CN1CCN(c2ccc(Cl)cc2)CC1	10.1016/s0960-894x(01)00814-9
		71734127	97832	0	None	-6760	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
		CHEMBL2397476	97832	0	None	-6760	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
		10247561	104780	0	None	-3	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		CHEMBL272873	104780	0	None	-3	4	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		118711252	120727	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(N)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325901	120727	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(N)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		71562965	94349	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
		CHEMBL2335739	94349	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	2	1	3	3.9	COc1ccc2c(c1)CCN1CC[C@@](O)(c3ccc(Cl)cc3)C[C@H]21	10.1016/j.bmcl.2012.12.046
		24829343	165800	0	None	-4265	9	Human	5.5	pKi	=	5.5	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
		CHEMBL409662	165800	0	None	-4265	9	Human	5.5	pKi	=	5.5	Binding	Inhibition of dopamine D1 receptorInhibition of dopamine D1 receptor	ChEMBL	429	7	1	3	5.1	CCC1(CCCCN2CCN(c3ccc(Cl)cc3)CC2)C(=O)Nc2cc(F)ccc21	10.1021/jm070279v
		112500031	139246	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	0	5	4.3	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697608	139246	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	0	5	4.3	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)cnc(=O)n1C	nan
		70682090	82844	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057451	82844	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70682090	82844	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		CHEMBL2057451	82844	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	323	2	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1Cc3cc(C)cc(C)c3CN1CC2	nan
		72708128	98980	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425378	98980	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
		11154555	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		5037	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		7671	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL2028019	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL3085826	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		DB06016	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		2105	9828	37	None	-123	32	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		47811	9828	37	None	-123	32	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		48	9828	37	None	-123	32	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		CHEMBL531	9828	37	None	-123	32	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		DB01186	9828	37	None	-123	32	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	nan
		86764215	139235	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697597	139235	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	4	4.6	Cc1cc(Oc2ncccc2C(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		10537185	32457	0	None	-12	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		CHEMBL135224	32457	0	None	-12	2	Rat	7.5	pKi	=	7.5	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	225	1	2	2	2.4	N[C@@H]1Cc2ccc(O)cc2[C@H]1c1ccccc1	10.1021/jm960318v
		86767087	136194	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	318	3	1	4	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnn1C	nan
		CHEMBL3671273	136194	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	318	3	1	4	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnn1C	nan
		9948254	115046	0	None	-141	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm00402a024
		CHEMBL31973	115046	0	None	-141	2	Rat	6.5	pKi	=	6.5	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	263	2	0	1	4.2	CCCN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm00402a024
		15115515	115383	0	None	-47	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL320526	115383	0	None	-47	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	713	8	5	8	8.2	CCCN(CCc1ccc(N/C(S)=N/c2ccc3c(c2)C(=O)OC32c3ccc(O)cc3Oc3cc(O)ccc32)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		167715	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		969	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		CHEMBL225230	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00168a040
		53317727	64717	0	None	-14	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	313	3	1	3	3.5	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
		CHEMBL1672313	64717	0	None	-14	3	Human	6.5	pKi	=	6.5	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	313	3	1	3	3.5	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
		11121216	36912	0	None	-169	14	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		CHEMBL138989	36912	0	None	-169	14	Mouse	6.5	pKi	=	6.5	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	335	1	1	2	3.0	C[C@@H]1C[C@@H](C)N1C(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)CC2N(C)C1	10.1021/jm020153s
		167715	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
		969	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
		CHEMBL225230	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00105a005
		44395741	188360	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
		CHEMBL476935	188360	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
		CHEMBL558392	188360	0	None	-23	10	Pig	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	360	6	0	3	4.3	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	10.1021/jm100899z
		56597938	10712	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		7651	10712	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		CHEMBL2165126	10712	3	None	-870	9	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.7b00363
		167715	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		969	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		CHEMBL225230	9651	14	None	-954	5	Rat	6.5	pKi	=	6.5	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00163a007
		44454734	104503	0	None	-912	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1	10.1016/j.bmcl.2007.12.026
		CHEMBL271513	104503	0	None	-912	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1	10.1016/j.bmcl.2007.12.026
		25130816	194490	0	None	-20	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	490	8	2	5	5.8	CCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL495327	194490	0	None	-20	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	490	8	2	5	5.8	CCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		45483654	204897	0	None	-14	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7cccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)c7)nn6)cc5)cc4)nn3)c2)CC1	10.1021/jm901120h
		CHEMBL574569	204897	0	None	-14	5	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7cccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)c7)nn6)cc5)cc4)nn3)c2)CC1	10.1021/jm901120h
		2779264	118119	38	None	-30	4	Bovine	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	240	3	0	2	3.3	c1ccc(CN2CCC(n3cccc3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		CHEMBL326877	118119	38	None	-30	4	Bovine	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	240	3	0	2	3.3	c1ccc(CN2CCC(n3cccc3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		42605994	24646	0	None	-16	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1	10.1021/jm100835q
		CHEMBL1259071	24646	0	None	-16	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	425	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3cc(Br)cs3)CC2)nc1	10.1021/jm100835q
		11566745	81469	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
		CHEMBL1202298	81469	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
		CHEMBL203029	81469	0	None	-1	4	Human	6.5	pKi	=	6.5	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	283	0	2	3	2.7	CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1	10.1021/jm050846j
		167715	9651	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		969	9651	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		CHEMBL225230	9651	14	None	-954	5	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm701045j
		11154555	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		5037	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		7671	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL2028019	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		CHEMBL3085826	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		DB06016	7587	62	None	-1445	12	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from D1 receptor (unknown origin) expressed in HEK293T cell membranes measured after 2 hrs by microbeta scintillation counting method	ChEMBL	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	10.1021/acs.jmedchem.1c01327
		7077	73733	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		CHEMBL186720	73733	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		CHEMBL3925724	73733	27	None	-3	5	Human	6.5	pKi	=	6.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	10.1021/jm049720x
		3158	63041	27	None	-2398	20	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		CHEMBL1628227	63041	27	None	-2398	20	Human	6.5	pKi	=	6.5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	279	3	0	2	4.0	CN(C)CCC=C1c2ccccc2COc2ccccc21	nan
		72708128	98980	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
		CHEMBL2425378	98980	0	None	-10	2	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	295	0	1	4	2.8	Oc1cccc2c1CN1CCc3cc4c(cc3C1C2)OCO4	10.1016/j.ejmech.2013.07.036
		117774393	139236	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	307	3	1	4	3.5	Cc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c1	nan
		CHEMBL3697598	139236	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	307	3	1	4	3.5	Cc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c1	nan
		44588898	19375	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL1186959	19375	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL484352	19375	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	331	2	3	3	4.0	Oc1cc2c(c(-c3ccccc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		25256815	196333	0	None	-51	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	397	6	0	3	3.9	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL514382	196333	0	None	-51	3	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	397	6	0	3	3.9	O=C1c2ccccc2CCN1CCCCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2009.01.067
		10833201	175390	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	373	2	0	3	4.7	CCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		CHEMBL436042	175390	0	None	-	1	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	373	2	0	3	4.7	CCN1CCc2c(Br)ccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		10707972	175835	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
		CHEMBL439639	175835	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm991034o
		72708127	98978	0	None	-40	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425376	98978	0	None	-40	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		13091359	120316	0	None	-489	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		CHEMBL3321790	120316	0	None	-489	10	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccc(F)cc1	10.1016/j.bmcl.2014.07.018
		112500033	139249	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697611	139249	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		118711265	120736	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	345	2	2	3	4.4	CN1CCc2cc(-c3ccc(O)cc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325916	120736	0	None	2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	345	2	2	3	4.4	CN1CCc2cc(-c3ccc(O)cc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		44415551	87084	0	None	269	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL214142	87084	0	None	269	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(Cl)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		2726	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		621	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		83	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		CHEMBL71	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		DB00477	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00067a009
		6852376	98374	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
		CHEMBL1467585	98374	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
		CHEMBL24077	98374	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
		CHEMBL503958	98374	13	None	-4	5	Rat	7.5	pKi	=	7.5	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm970038v
		2726	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		621	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		83	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		CHEMBL71	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		DB00477	7706	68	None	-18	72	Rat	7.5	pKi	=	7.5	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00030a011
		10402378	72899	0	None	-19	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	1	0	3	3.2	COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2	10.1021/jm049720x
		CHEMBL184049	72899	0	None	-19	5	Human	7.5	pKi	=	7.5	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	297	1	0	3	3.2	COc1ccc2c(c1)OCCN(C)CCc1ccccc1C2	10.1021/jm049720x
		86764105	139260	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	3	1	5	3.6	Cc1cc(Sc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697623	139260	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	3	1	5	3.6	Cc1cc(Sc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		6603820	102549	19	None	-4	12	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2009.08.028
		CHEMBL25856	102549	19	None	-4	12	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.bmc.2009.08.028
		90140110	136216	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cn[nH]c(=O)c1C	nan
		CHEMBL3671294	136216	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cn[nH]c(=O)c1C	nan
		70690499	82846	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057453	82846	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.05.057
		70690499	82846	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.12.016
		CHEMBL2057453	82846	0	None	9	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	311	2	1	4	3.1	COc1ccc2c(c1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2012.12.016
		135398737	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		38	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		722	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		CHEMBL42	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		DB00363	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		24882561	102116	0	None	-2041	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	408	8	0	5	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
		CHEMBL256637	102116	0	None	-2041	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	408	8	0	5	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
		44403225	77323	0	None	-346	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	421	9	1	5	2.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
		CHEMBL194755	77323	0	None	-346	5	Pig	5.5	pKi	=	5.5	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	421	9	1	5	2.7	COc1ccccc1N1CCN(CCCCNS(=O)(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2005.07.037
		44436596	98771	1	None	-436	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1ccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL241631	98771	1	None	-436	4	Pig	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	401	5	1	3	3.5	C#Cc1ccc(C(=O)NCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		10707972	175835	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
		CHEMBL439639	175835	0	None	1	2	Rat	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	10.1021/jm060959i
		44567588	197006	0	None	-45	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	325	3	2	4	3.6	CCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		CHEMBL517491	197006	0	None	-45	2	Mouse	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	325	3	2	4	3.6	CCCOc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.bmc.2008.02.038
		90644230	118567	0	None	-1819	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		CHEMBL3287406	118567	0	None	-1819	5	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cc2cc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)ccn2n1	10.1021/jm5004039
		10479188	209652	0	None	-316	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL62602	209652	0	None	-316	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		44319370	113824	0	None	-1	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
		CHEMBL315564	113824	0	None	-1	4	Bovine	5.5	pKi	=	5.5	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
		44380717	127127	0	None	-138	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL353087	127127	0	None	-138	4	Bovine	4.5	pKi	=	4.5	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		56926587	75785	0	None	-2290	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	329	3	0	5	2.3	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cn1	10.1021/jm200762g
		CHEMBL1923416	75785	0	None	-2290	5	Pig	4.5	pKi	=	4.5	Binding	Displacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]WAY100635 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	329	3	0	5	2.3	Fc1ccc(CN2CCN(c3ccc4c(c3)OCCO4)CC2)cn1	10.1021/jm200762g
		118711253	120728	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(O)c(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325903	120728	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	268	1	2	3	2.6	CN1CCc2cc(O)c(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		135398737	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		38	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		722	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		CHEMBL42	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		DB00363	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm9706832
		135398737	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		38	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		722	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		CHEMBL42	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		DB00363	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm800689g
		135398737	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		38	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		722	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		CHEMBL42	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		DB00363	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0309811
		135398737	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		38	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		722	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		CHEMBL42	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		DB00363	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049629t
		112500030	139245	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		CHEMBL3697607	139245	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	3	0	5	4.9	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)cnc(=O)n1C	nan
		135398737	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		38	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		722	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		CHEMBL42	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		DB00363	7745	93	None	-83	90	Rat	6.5	pKi	=	6.5	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm010982y
		1353	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		3559	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		86	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		CHEMBL54	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		DB00502	8692	93	None	-74	85	Rat	6.5	pKi	=	6.5	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049632c
		681	8247	72	None	-23	38	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		940	8247	72	None	-23	38	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		947	8247	72	None	-23	38	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		CHEMBL59	8247	72	None	-23	38	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		DB00988	8247	72	None	-23	38	Bovine	7.4	pKi	=	7.4	Binding	Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on relative proportion of High Affinity Site of Bovine dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		135398745	9688	112	None	-26	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		47	9688	112	None	-26	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		CHEMBL715	9688	112	None	-26	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		DB00334	9688	112	None	-26	65	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	nan
		117772904	139197	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	5	3.0	Cc1cc(Oc2nccc(C)c2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697560	139197	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	5	3.0	Cc1cc(Oc2nccc(C)c2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		90666903	116226	0	None	-4	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	452	4	1	5	5.0	O=C1CC(CN2CCC(c3c[nH]c4cc(F)ccc34)CC2)Cc2nc(N3CCCC3)sc21	10.1039/C1MD00202C
		CHEMBL3220219	116226	0	None	-4	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	452	4	1	5	5.0	O=C1CC(CN2CCC(c3c[nH]c4cc(F)ccc34)CC2)Cc2nc(N3CCCC3)sc21	10.1039/C1MD00202C
		155552185	180840	0	None	-660	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		CHEMBL4544086	180840	0	None	-660	16	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H] SCH23390 from D1 receptor (unknown origin)Displacement of [3H] SCH23390 from D1 receptor (unknown origin)	ChEMBL	491	10	2	5	4.3	COc1ccccc1N1CCN(CCCNC(=O)NN(Cc2ccc(F)cc2)c2ccccc2)CC1	10.1021/acs.jmedchem.9b01085
		118709173	120198	0	None	-218	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	20	0	10	9.4	O=C(CCN1CCN(CCC(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318846	120198	0	None	-218	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	944	20	0	10	9.4	O=C(CCN1CCN(CCC(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		72545240	99904	0	None	-229	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	469	12	0	8	3.4	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443007	99904	0	None	-229	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	469	12	0	8	3.4	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		52937777	67945	0	None	-6165	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	464	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(Cl)c2C1	10.1021/jm101639t
		CHEMBL1765630	67945	0	None	-6165	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	464	10	1	4	5.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2ncc(Cl)c2C1	10.1021/jm101639t
		57395340	76075	0	None	-407	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
		CHEMBL1928124	76075	0	None	-407	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	469	14	1	6	3.6	CCOCCOCc1ccc(C(=O)NCCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
		71734029	97830	0	None	-10964	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
		CHEMBL2397392	97830	0	None	-10964	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cnn3ccccc23)CC1	10.1021/jm400520c
		14198593	205453	1	None	4	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		CHEMBL57988	205453	1	None	4	2	Rat	5.4	pKi	=	5.4	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		10064053	102682	0	None	-1995	6	Rat	5.4	pKi	=	5.4	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm960189i
		CHEMBL25924	102682	0	None	-1995	6	Rat	5.4	pKi	=	5.4	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	311	1	0	1	5.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(-c2ccccc2)c1-3	10.1021/jm960189i
		10546334	72020	0	None	-2187	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	358	4	2	4	4.0	c1ccc2c(N3CCN(CCc4ccc5c(c4)NCN5)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
		CHEMBL182721	72020	0	None	-2187	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	358	4	2	4	4.0	c1ccc2c(N3CCN(CCc4ccc5c(c4)NCN5)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
		57580939	98976	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425374	98976	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		154726529	183224	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4467486	183224	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596338	183224	1	None	-33	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	459	12	1	3	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		15711870	19728	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL1189332	19728	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL538520	19728	0	None	-1	3	Rat	6.4	pKi	=	6.4	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		154704418	183366	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4546749	183366	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4597533	183366	1	None	1	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	458	12	1	6	4.8	Cn1c(SCCCNCC2CC2c2cc(F)ccc2OCCF)nnc1-c1ccccc1	10.1021/acs.jmedchem.9b01835
		44567688	199054	0	None	-8	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	295	2	1	3	3.5	CCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
		CHEMBL520573	199054	0	None	-8	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	295	2	1	3	3.5	CCOc1cccc2c1-c1cc(O)cc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2008.06.016
		42625293	63023	0	None	-912	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	549	8	2	6	3.3	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
		CHEMBL1627319	63023	0	None	-912	3	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	549	8	2	6	3.3	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
		3036864	209533	19	None	-26	27	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1256645	209533	19	None	-26	27	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL1814790	209533	19	None	-26	27	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		CHEMBL62	209533	19	None	-26	27	Bovine	7.4	pKi	=	7.4	Binding	Ability to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid glandAbility to inhibit the dopamine-stimulated adenylate-cyclase activity in dispersed cells of bovine parathyroid gland	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00164a009
		133	9274	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		1723	9274	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		28693	9274	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		CHEMBL19215	9274	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		DB13520	9274	52	None	-30	43	Human	7.4	pKi	=	7.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	nan
		24847750	189982	9	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/np50094a001
		CHEMBL479587	189982	9	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	361	0	1	2	4.8	CC(C)(C)[C@]1(O)CCN2C[C@@H]3c4ccccc4CCc4cccc(c43)[C@H]2C1	10.1021/np50094a001
		5281878	8441	35	None	-11	16	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		5281881	8441	35	None	-11	16	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		948	8441	35	None	-11	16	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		968	8441	35	None	-11	16	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		CHEMBL42055	8441	35	None	-11	16	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		CHEMBL54661	8441	35	None	-11	16	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		DB00875	8441	35	None	-11	16	Rat	7.4	pKi	=	7.4	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	10.1021/jm9706832
		11777127	32582	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		CHEMBL135318	32582	0	None	1	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	255	1	2	3	2.7	CN1CCc2cc(O)c(O)cc2C1c1ccccc1	10.1021/jm00051a008
		118711256	120731	0	None	-37	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1cccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325906	120731	0	None	-37	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1cccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)c1	10.1016/j.ejmech.2014.07.059
		15115516	16540	0	None	-1148	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL113527	16540	0	None	-1148	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	487	9	2	8	5.4	CCCN(CCc1ccc(Nc2ccc([N+](=O)[O-])c3nonc23)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		53317511	64712	0	None	-107	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	329	3	2	4	3.2	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
		CHEMBL1672308	64712	0	None	-107	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	329	3	2	4	3.2	CN1CCc2cc(OCCF)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
		44380816	127129	0	None	-77	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL353090	127129	0	None	-77	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		44448059	101595	0	None	5	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		CHEMBL253530	101595	0	None	5	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		137655451	165632	0	None	-288	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4094869	165632	0	None	-288	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		3033769	10054	61	None	-10232	18	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		3299	10054	61	None	-10232	18	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		94	10054	61	None	-10232	18	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		CHEMBL8809	10054	61	None	-10232	18	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		DB12518	10054	61	None	-10232	18	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	10.1016/j.bmc.2007.07.017
		10544858	176807	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
		CHEMBL444269	176807	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
		CHEMBL542181	176807	0	None	-40	4	Rat	5.4	pKi	=	5.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	336	4	0	4	3.2	COc1ccccc1N1CCN(CC2CC(=O)c3ccccc32)CC1	10.1021/jm981094e
		228	7233	28	None	-35	23	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		33	7233	28	None	-35	23	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		6005	7233	28	None	-35	23	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		CHEMBL53	7233	28	None	-35	23	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		DB00714	7233	28	None	-35	23	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assayDisplacement of [3H]SCH23390 from human D1 receptor expressed in L cells incubated for 60 mins by radio ligand binding assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmcl.2020.127053
		16573	184398	34	None	-18	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		CHEMBL464099	184398	34	None	-18	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEKT cell membranes by radioligand binding assay	ChEMBL	341	3	1	5	3.2	COc1cc2c(cc1O)C[C@H]1c3c(cc(OC)c(OC)c3-2)CCN1C	10.1021/np500893h
		44320267	212991	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL86576	212991	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	301	4	3	5	2.1	NC[C@@H]1OC(COc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		44278297	105852	0	None	-2511	3	Rat	4.4	pKi	=	4.4	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	382	4	0	2	5.0	O=C(c1cccc(CN2CCC(c3ccc(Cl)cc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
		CHEMBL280534	105852	0	None	-2511	3	Rat	4.4	pKi	=	4.4	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	382	4	0	2	5.0	O=C(c1cccc(CN2CCC(c3ccc(Cl)cc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
		130442557	173852	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4289538	173852	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	342	3	0	6	4.7	Cc1nc2cnccc2n1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		71110287	153103	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL3921127	153103	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	369	3	0	6	3.1	COc1cc2c(c(OC)c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		235224	134933	29	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
		CHEMBL36654	134933	29	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	279	0	0	3	3.2	CN1CCc2cc3c(c4c2C1Cc1ccccc1-4)OCO3	10.1016/j.bmcl.2013.06.078
		72708127	98978	0	None	-40	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425376	98978	0	None	-40	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	283	0	3	4	2.5	Oc1cc2c(cc1O)C1Cc3cccc(O)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		44396235	175316	1	None	-23	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	281	6	0	2	3.8	c1ccc(Cc2ccccc2OCCN2CCCC2)cc1	10.1021/jm049720x
		CHEMBL435505	175316	1	None	-23	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	281	6	0	2	3.8	c1ccc(Cc2ccccc2OCCN2CCCC2)cc1	10.1021/jm049720x
		72699718	121972	0	None	-11	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	355	3	1	4	4.5	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CCC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344465	121972	0	None	-11	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	355	3	1	4	4.5	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CCC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		135458464	87903	0	None	-1122	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	486	3	1	5	6.2	FC(F)(F)Oc1cccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL215669	87903	0	None	-1122	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	486	3	1	5	6.2	FC(F)(F)Oc1cccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c1	10.1016/j.bmcl.2006.06.034
		46231783	207312	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	357	1	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C(=O)O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		CHEMBL598915	207312	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	357	1	2	3	3.7	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(C(=O)O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.094
		130442473	174116	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4294397	174116	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1cc(Oc2nccc3occc23)ccc1-c1cccc2nccn12	10.1021/acs.jmedchem.8b01622
		86764318	139238	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	349	4	1	5	3.1	Cc1c(-c2ccc(Oc3ncccc3C3CC3)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697600	139238	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	349	4	1	5	3.1	Cc1c(-c2ccc(Oc3ncccc3C3CC3)cc2)n(C)c(=O)[nH]c1=O	nan
		117773358	139195	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	3	1	5	4.2	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697558	139195	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	3	1	5	4.2	Cc1cc(Oc2ncc(Cl)c(C)c2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		23625925	100346	0	None	-18	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	368	3	1	5	3.3	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]ncc21	10.1039/C1MD00202C
		CHEMBL246484	100346	0	None	-18	7	Human	7.4	pKi	=	7.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	368	3	1	5	3.3	O=C1CC(CN2CCC(c3noc4cc(F)ccc34)CC2)Cc2[nH]ncc21	10.1039/C1MD00202C
		10436653	39566	1	None	-562	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	521	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[te]2)CC1	10.1021/jm025558r
		CHEMBL141419	39566	1	None	-562	5	Human	6.4	pKi	=	6.4	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	521	8	1	4	3.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[te]2)CC1	10.1021/jm025558r
		147230103	186932	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2020.127563
		CHEMBL4748915	186932	0	None	3	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	323	1	1	3	4.8	CN1CC=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1	10.1016/j.bmcl.2020.127563
		53327908	68383	0	None	-3162	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	470	8	0	5	4.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccncc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771112	68383	0	None	-3162	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	470	8	0	5	4.4	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccncc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		3082625	201507	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL53510	201507	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm060959i
		53327665	73254	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
		CHEMBL1852240	73254	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
		CHEMBL3216759	73254	0	None	-38	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	400	4	3	7	2.4	COC(=O)[C@@H](N)CSc1cc2c3c(c1)-c1c(ccc(O)c1O)C[C@H]3N(C)CC2	10.1016/j.ejmech.2011.04.028
		128434	202485	8	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	227	1	3	3	2.2	NCC1c2ccccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
		CHEMBL55693	202485	8	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	227	1	3	3	2.2	NCC1c2ccccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
		10386748	111529	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
		CHEMBL310734	111529	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
		10386748	111529	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL310734	111529	0	None	-15	3	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	408	7	0	4	3.9	O=C(CCCN1CCN(CC2CC(=O)c3ccccc3C2)CC1)c1ccc(F)cc1	10.1021/jm981094e
		53363199	70626	0	None	-457	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	481	12	0	9	3.2	CCOCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803051	70626	0	None	-457	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	481	12	0	9	3.2	CCOCCn1cc(COc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		25139477	191024	0	None	-870	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	486	10	1	2	6.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
		CHEMBL483593	191024	0	None	-870	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	486	10	1	2	6.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
		49782603	24261	0	None	-151	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	385	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
		CHEMBL1257811	24261	0	None	-151	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	385	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
		137634397	162884	0	None	-11748	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
		CHEMBL4063145	162884	0	None	-11748	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
		10802235	20031	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL1191487	20031	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL542593	20031	0	None	-1	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@@H]1CC2	10.1021/jm970038v
		72545238	99902	0	None	-7413	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	425	9	0	7	3.3	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443005	99902	0	None	-7413	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	425	9	0	7	3.3	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		112500028	139243	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697605	139243	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	0	5	3.9	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		56971032	76024	0	None	-114	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccccn1	10.1016/j.ejmech.2011.11.023
		CHEMBL1927094	76024	0	None	-114	3	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	382	6	1	5	2.8	N#C/N=C(\NCCCN1CCN(c2cccc(Cl)c2)CC1)c1ccccn1	10.1016/j.ejmech.2011.11.023
		3082625	201507	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00004a011
		CHEMBL53510	201507	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1Ability to displace [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm00004a011
		3082625	201507	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL53510	201507	8	None	-199	4	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		44582675	196480	0	None	-64	15	Human	5.4	pKi	=	5.4	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL515472	196480	0	None	-64	15	Human	5.4	pKi	=	5.4	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1[C@H](O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		10786190	121510	0	None	-50	3	Rat	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	383	2	0	4	3.7	CN1CCc2cccc3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm960189i
		CHEMBL333836	121510	0	None	-50	3	Rat	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	383	2	0	4	3.7	CN1CCc2cccc3c2[C@H]1Cc1cccc(OS(=O)(=O)C(F)(F)F)c1-3	10.1021/jm960189i
		44406003	139936	0	None	4	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
		CHEMBL370364	139936	0	None	4	3	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	463	5	2	5	3.5	Cc1ccc(-c2cc3c(=O)n(CCN4CCN(c5ccccc5Cl)CC4)c(=O)[nH]c3[nH]2)cc1	10.1016/j.bmcl.2005.09.027
		448537	167029	89	None	-28	25	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		CHEMBL411	167029	89	None	-28	25	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	nan
		10813037	53931	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	439	3	1	3	4.7	COc1ccc(Br)c(CC2c3c(O)ccc(Br)c3CCN2C)c1	10.1021/jm991034o
		CHEMBL154301	53931	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	439	3	1	3	4.7	COc1ccc(Br)c(CC2c3c(O)ccc(Br)c3CCN2C)c1	10.1021/jm991034o
		90644059	118807	0	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		CHEMBL3289643	118807	0	None	-22	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	354	4	0	3	3.9	O=C1c2ccccc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		10781204	126827	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	309	3	0	3	4.4	CCCN1CCc2cccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		CHEMBL350457	126827	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	309	3	0	3	4.4	CCCN1CCc2cccc3c2C1Cc1cc(OC)ccc1O3	10.1021/jm991034o
		76321556	113154	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3115578	113154	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3139302	113154	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		76325150	113199	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		CHEMBL3115575	113199	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		CHEMBL3139554	113199	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		44415658	148350	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	527	3	1	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3sccc3-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL384916	148350	0	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	527	3	1	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3sccc3-c3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		25110706	19376	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL1186960	19376	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL484356	19376	0	None	19	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	345	2	3	3	4.4	Cc1cccc(-c2c(O)c(O)cc3c2CCNCC3c2ccccc2)c1	10.1016/j.bmc.2008.09.049
		86767096	136206	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C#N	nan
		CHEMBL3671285	136206	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.3	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncnc1C#N	nan
		2337	10030	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		50	10030	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		5002	10030	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		CHEMBL716	10030	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		DB01224	10030	77	None	-53	62	Human	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm0002432
		44276572	103423	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL26365	103423	0	None	2	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	286	0	3	4	2.2	Oc1cc2c(cc1O)[C@H]1c3cncc(F)c3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		53364225	70619	0	None	-117	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	932	25	0	18	5.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCOCCOCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803027	70619	0	None	-117	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	932	25	0	18	5.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCc1cn(CCOCCOCCn2cc(COc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		30133	74412	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
		CHEMBL190519	74412	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
		CHEMBL541862	74412	8	None	-6	3	Rat	6.4	pKi	=	6.4	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	253	0	3	3	2.5	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)NCC3	10.1021/jm00163a007
		10667966	63934	0	None	-2	4	Bovine	5.4	pKi	=	5.4	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	387	5	0	1	6.1	CCCN(CCC)C1CCC(=C(C#C[Si](C)(C)C)C#C[Si](C)(C)C)CC1	10.1021/jm991098z
		CHEMBL164736	63934	0	None	-2	4	Bovine	5.4	pKi	=	5.4	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	387	5	0	1	6.1	CCCN(CCC)C1CCC(=C(C#C[Si](C)(C)C)C#C[Si](C)(C)C)CC1	10.1021/jm991098z
		44412182	84041	0	None	-3890	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL208018	84041	0	None	-3890	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1nn(-c2ccccc2)cc1CN1CCN(c2ccccc2)CC1	10.1016/j.bmcl.2006.02.075
		122177642	127988	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
		CHEMBL3577343	127988	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	551	18	1	8	4.6	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2ccc(OCCCc3cn(CCCC)nn3)c(OC)c2)CO1	10.1021/jm501889t
		24823921	104672	0	None	-21	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
		CHEMBL272395	104672	0	None	-21	4	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	371	3	0	5	2.8	Brc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
		9995378	12245	0	None	-301	4	Bovine	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3ccc(-c4cnco4)c3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		CHEMBL107529	12245	0	None	-301	4	Bovine	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	307	4	0	4	4.0	c1ccc(CN2CCC(n3ccc(-c4cnco4)c3)CC2)cc1	10.1016/s0960-894x(99)00540-5
		10359539	65828	10	None	-125	4	Bovine	4.4	pKi	=	4.4	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
		CHEMBL169459	65828	10	None	-125	4	Bovine	4.4	pKi	=	4.4	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	334	4	1	4	2.6	c1ccc(C2=NCC[C@@H](CN3CCN(c4ccccc4)CC3)N2)cc1	10.1016/s0960-894x(03)00004-0
		91899759	136223	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	342	3	1	6	3.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1C#N	nan
		CHEMBL3671300	136223	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	342	3	1	6	3.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1C#N	nan
		57580939	98976	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425374	98976	0	None	-10	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1cc2c(cc1OC)C1Cc3cccc(OC)c3CN1CC2	10.1016/j.ejmech.2013.07.036
		1242	10385	27	None	-5	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
		935	10385	27	None	-5	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
		CHEMBL286080	10385	27	None	-5	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.bmc.2009.06.019
		1242	10385	27	None	-5	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
		935	10385	27	None	-5	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
		CHEMBL286080	10385	27	None	-5	17	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1016/j.ejmech.2014.07.059
		10333837	120311	0	None	-51	3	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	0	2	3.8	COc1c(C)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL332178	120311	0	None	-51	3	Rat	6.4	pKi	=	6.4	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	0	2	3.8	COc1c(C)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		25130157	110084	0	None	-5495	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	367	3	1	3	5.1	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12	10.1021/jm800532x
		CHEMBL3084515	110084	0	None	-5495	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	367	3	1	3	5.1	O[C@]1(c2ccc(Cl)cc2)C[C@@H]2CC[C@H](C1)N2Cc1coc2ccccc12	10.1021/jm800532x
		135409492	175949	50	None	-4	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	0	1	5	3.5	Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1	10.1016/S0960-894X(96)00567-7
		CHEMBL440512	175949	50	None	-4	3	Human	6.4	pKi	=	6.4	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	0	1	5	3.5	Cc1cc2c(s1)Nc1ccccc1N=C2N1CC[N+](C)([O-])CC1	10.1016/S0960-894X(96)00567-7
		15467370	109095	0	None	-3630	4	Bovine	4.4	pKi	=	4.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
		CHEMBL303538	109095	0	None	-3630	4	Bovine	4.4	pKi	=	4.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccc(Cl)cc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
		76321556	113154	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3115578	113154	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3139302	113154	0	None	-407	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	493	6	2	5	3.1	Oc1ccc2c(c1)O[C@@H](CNCCN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		151086	98753	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
		CHEMBL2414991	98753	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
		3802	209802	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm960084f
		CHEMBL63329	209802	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm960084f
		3802	209802	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm00067a009
		CHEMBL63329	209802	21	None	-19	5	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	1	5	2.8	Cc1ccc2c(c1)C(N1CCN(C)CC1)=Nc1cccnc1N2	10.1021/jm00067a009
		4302960	107838	63	None	-1258	6	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	485	10	1	5	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		CHEMBL294747	107838	63	None	-1258	6	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	485	10	1	5	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccc(C(C)=O)cc3)cc2)CC1	10.1016/0960-894X(95)00011-H
		10247701	92658	0	None	-2398	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	4	1	3	4.1	c1ccc2c(N3CCN(CCc4ccc5[nH]cnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
		CHEMBL2298806	92658	0	None	-2398	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	356	4	1	3	4.1	c1ccc2c(N3CCN(CCc4ccc5[nH]cnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
		162657175	187612	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	331	2	1	3	5.1	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4756987	187612	0	None	41	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	331	2	1	3	5.1	CCc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
		16007117	86811	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212912	86811	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415518	86853	0	None	45	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213084	86853	0	None	45	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(Cl)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415724	87033	0	None	97	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	547	2	1	5	6.4	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cc(Cl)cc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213881	87033	0	None	97	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	547	2	1	5	6.4	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(Cl)cc(Cl)cc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11637457	79862	1	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1039/C5MD00258C
		CHEMBL201093	79862	1	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2ccsc2CC1	10.1039/C5MD00258C
		71562964	94350	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2335740	94350	0	None	3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	359	2	2	4	3.6	COc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		37459	7533	13	None	-10	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
		62	7533	13	None	-10	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
		CHEMBL8514	7533	13	None	-10	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmcl.2020.127305
		16007117	86811	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212912	86811	0	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	479	2	1	5	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		15111049	20727	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
		CHEMBL1196674	20727	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
		CHEMBL557799	20727	0	None	1412	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	317	1	2	2	3.4	Oc1cc2c(cc1Br)CCNCC2c1ccccc1	10.1021/jm00079a008
		74223771	136198	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		CHEMBL3671277	136198	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		86764214	139234	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	4	1	5	4.6	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)(F)F	nan
		CHEMBL3697596	139234	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	405	4	1	5	4.6	COc1ccnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)c(C)c2)c1C(F)(F)F	nan
		71109897	94288	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL2334893	94288	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	10.1016/j.bmc.2012.12.016
		134145434	156188	0	None	173	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	449	5	2	6	3.6	COCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3945691	156188	0	None	173	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	449	5	2	6	3.6	COCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		45379369	14294	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1	10.1021/jm901291r
		CHEMBL1087300	14294	0	None	-1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation countingDisplacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in HEK293 cells by microplate scintillation counting	ChEMBL	290	0	1	1	3.8	CN1CCc2ccccc2Cc2c[nH]c3cccc(c23)CC1	10.1021/jm901291r
		71109897	94288	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
		CHEMBL2334893	94288	0	None	7	2	Human	8.4	pKi	=	8.4	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	325	1	1	5	2.8	COc1cc2c(cc1O)[C@@H]1Cc3cc4c(cc3CN1CC2)OCO4	nan
		37459	7533	13	None	-10	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
		62	7533	13	None	-10	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
		CHEMBL8514	7533	13	None	-10	24	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting methodDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in HEKT cells incubated for 90 mins by microbeta counting method	ChEMBL	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	10.1016/j.bmc.2020.115578
		10518837	107249	0	None	33	2	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL290842	107249	0	None	33	2	Rat	8.4	pKi	=	8.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	307	0	3	4	3.4	Oc1cc2c(cc1O)[C@@H]1c3sc(Cl)cc3CN[C@H]1CC2	10.1021/jm970038v
		46231924	207357	0	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	370	2	1	4	4.0	CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		CHEMBL599134	207357	0	None	5	4	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation countingDisplacement of [3H]SCh23390 from dopamine D1 receptor expressed in mouse LTK cells by scintillation counting	ChEMBL	370	2	1	4	4.0	CO/N=C/c1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.094
		5249956	80170	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2006.11.093
		CHEMBL201525	80170	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cellsDisplacement of [3H]SCH 23390 from human cloned dopamine D1 receptor expressed in HEK 293 cells	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1016/j.bmcl.2006.11.093
		5249956	80170	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1039/C5MD00258C
		CHEMBL201525	80170	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1039/C5MD00258C
		440229	94286	53	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2334891	94286	53	None	1	5	Human	8.4	pKi	=	8.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		5249956	80170	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
		CHEMBL201525	80170	1	None	-4	6	Human	8.4	pKi	=	8.4	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	251	0	0	1	3.3	CN1CCc2ccccc2Cc2ccccc2CC1	10.1021/jm050846j
		74223826	136215	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3671293	136215	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	5	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc(=O)n1C	nan
		228	7233	28	None	-35	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		33	7233	28	None	-35	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		6005	7233	28	None	-35	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		CHEMBL53	7233	28	None	-35	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		DB00714	7233	28	None	-35	23	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		86767083	136189	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	4	5.3	[C-]#[N+]c1c[nH]c2ccnc(Oc3ccc(-c4c(C)ncnc4C)c(C)c3)c12	nan
		CHEMBL3671268	136189	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	4	5.3	[C-]#[N+]c1c[nH]c2ccnc(Oc3ccc(-c4c(C)ncnc4C)c(C)c3)c12	nan
		44323851	213753	0	None	3	4	Rat	8.3	pKi	=	8.3	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL91310	213753	0	None	3	4	Rat	8.3	pKi	=	8.3	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	302	1	0	2	3.8	C=C1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		46231770	208089	0	None	213	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NS(C)(=O)=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL604135	208089	0	None	213	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	406	2	2	4	3.4	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NS(C)(=O)=O)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		74223772	136200	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3671279	136200	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		25110705	19512	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL1187785	19512	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL520821	19512	0	None	5	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	409	2	2	3	5.8	Cc1cccc(C2CN(C)CCc3c2cc(O)c(O)c3-c2ccc3ccccc3c2)c1	10.1016/j.bmc.2008.09.049
		146266	107474	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
		CHEMBL292418	107474	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
		CHEMBL540857	107474	8	None	-2	4	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	273	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNCC2c1ccccc1	10.1021/jm00079a008
		11324141	70632	0	None	1	3	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	303	1	0	5	3.2	CN1CCN(C2=Cn3cccc3Sc3sccc32)CC1	10.1021/jm049629t
		CHEMBL180319	70632	0	None	1	3	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	303	1	0	5	3.2	CN1CCN(C2=Cn3cccc3Sc3sccc32)CC1	10.1021/jm049629t
		44386836	69796	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	342	3	0	4	3.6	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
		CHEMBL178797	69796	0	None	-1	2	Rat	7.4	pKi	=	7.4	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	342	3	0	4	3.6	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CN(C)CC2	10.1016/s0960-894x(98)00138-3
		1153	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		12668023	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		30026874	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		30026875	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		3341	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		6603851	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		933	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		939	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		985	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		CHEMBL1160786	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		CHEMBL1161520	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		CHEMBL588	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		DB00800	8409	58	None	-32	10	Human	7.4	pKi	=	7.4	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	10.1021/jm9800292
		122205438	144178	0	None	-26	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	307	0	0	2	4.5	CN1CCc2ccccc2Cc2sc3ccccc3c2CC1	10.1039/C5MD00258C
		CHEMBL3753266	144178	0	None	-26	5	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	307	0	0	2	4.5	CN1CCc2ccccc2Cc2sc3ccccc3c2CC1	10.1039/C5MD00258C
		71722299	109257	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL2397383	109257	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL3040217	109257	0	None	-1	3	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	373	2	3	4	4.1	CN1CCc2ccc(Cc3ccc(O)cc3)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		127031398	145585	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	411	8	1	5	5.0	CCCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3781035	145585	0	None	5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	411	8	1	5	5.0	CCCCCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		14198584	205048	0	None	12	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL57579	205048	0	None	12	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2C1c1ccccc1	10.1016/j.bmc.2009.05.079
		86763998	139252	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697614	139252	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	375	3	1	5	3.3	Cc1cc(Oc2ncc(F)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		74223832	136229	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
		CHEMBL3671306	136229	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	333	3	2	5	3.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1	nan
		53364083	70628	0	None	-28	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	658	21	0	11	6.2	CCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803053	70628	0	None	-28	4	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	658	21	0	11	6.2	CCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		44339992	115961	0	None	-501	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL321492	115961	0	None	-501	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		49782841	24424	0	None	-2511	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	523	7	1	4	6.1	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccccc2s1	10.1021/jm100899z
		CHEMBL1258382	24424	0	None	-2511	5	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	523	7	1	4	6.1	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccccc2s1	10.1021/jm100899z
		137633454	163370	0	None	-1230	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	645	16	3	10	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
		CHEMBL4068702	163370	0	None	-1230	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	645	16	3	10	4.4	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN3CCCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2OC)nn1	10.1021/acs.jmedchem.7b00363
		71454405	85200	0	None	-30	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL2111528	85200	0	None	-30	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
		44319102	212920	0	None	-16	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL86060	212920	0	None	-16	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
		11631892	84886	0	None	-30902	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	4	0	6	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1	10.1021/jm060166w
		CHEMBL210283	84886	0	None	-30902	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	4	0	6	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1	10.1021/jm060166w
		151086	98753	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
		CHEMBL2414991	98753	4	None	-9	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1-3	10.1016/j.bmcl.2013.06.078
		4011	89183	49	None	-64	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1016/j.bmcl.2008.09.012
		CHEMBL21731	89183	49	None	-64	24	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	10.1016/j.bmcl.2008.09.012
		118717796	121970	0	None	-14	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	4	1	4	4.7	CCC(C)Cc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344462	121970	0	None	-14	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	4	1	4	4.7	CCC(C)Cc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		11349297	92655	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	372	5	2	4	2.7	O=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
		CHEMBL2298800	92655	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	372	5	2	4	2.7	O=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
		72708060	98972	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425370	98972	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		44320123	113860	0	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL315849	113860	0	None	2	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	233	2	3	4	1.1	C#CCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		72708060	98972	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425370	98972	0	None	1	2	Rat	4.4	pKi	=	4.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	477	7	0	4	6.5	COc1ccc2c(c1)CC1c3cc(OCc4ccccc4)c(OCc4ccccc4)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		70692801	83338	0	None	-5	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
		CHEMBL2062850	83338	0	None	-5	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	362	5	1	3	3.6	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCC1	10.1016/j.ejmech.2012.07.025
		118709751	120318	0	None	-3162	10	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		CHEMBL3321792	120318	0	None	-3162	10	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	405	6	1	3	5.5	OC1(c2ccc(Cl)cc2)CC2CCC(C1)N2CCCSc1ccccc1F	10.1016/j.bmcl.2014.07.018
		156020547	184937	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	387	4	1	3	4.3	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4649012	184937	0	None	12	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	387	4	1	3	4.3	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		74223830	136228	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3671305	136228	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	6	3.1	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)ncc(=O)n1C	nan
		9909648	212352	3	None	-134	11	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm960084f
		CHEMBL81330	212352	3	None	-134	11	Rat	6.4	pKi	=	6.4	Binding	Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.Binding affinity of [3H]SCH-23,390 towards Dopamine receptor D1 in cloned mammalian receptor expressed in cultured cells or from rat whole brain.	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/jm960084f
		71463207	90849	0	None	-169	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	357	4	0	4	4.0	COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207636	90849	0	None	-169	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	357	4	0	4	4.0	COc1ccccc1N1CCN(Cc2cc(C#N)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		137640203	163741	0	None	-54	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
		CHEMBL4072821	163741	0	None	-54	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	452	10	0	8	3.5	CCOC(=O)c1cc2cc(OCCCCN3CCN(c4ccccc4OC)CC3)ccn2n1	10.1021/acs.jmedchem.6b01857
		10917920	118223	0	None	-5128	10	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	487	6	1	6	3.8	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		CHEMBL327527	118223	0	None	-5128	10	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	487	6	1	6	3.8	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCNC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		45482151	204788	0	None	-831	4	Pig	5.4	pKi	=	5.4	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	451	8	1	9	1.7	COc1ccccc1N1CCN(CCNC(=O)c2cn(-c3ccc([N+](=O)[O-])cc3)nn2)CC1	10.1016/j.bmc.2009.06.041
		CHEMBL573791	204788	0	None	-831	4	Pig	5.4	pKi	=	5.4	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	451	8	1	9	1.7	COc1ccccc1N1CCN(CCNC(=O)c2cn(-c3ccc([N+](=O)[O-])cc3)nn2)CC1	10.1016/j.bmc.2009.06.041
		44403220	78701	0	None	-169	5	Pig	5.4	pKi	=	5.4	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(F)n2)CC1	10.1016/j.bmcl.2005.07.037
		CHEMBL197214	78701	0	None	-169	5	Pig	5.4	pKi	=	5.4	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(F)n2)CC1	10.1016/j.bmcl.2005.07.037
		44380921	65103	0	None	-11	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		CHEMBL168274	65103	0	None	-11	4	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	9	2	4	4.7	CCC[C@H]1CN(Cc2ccccc2)C[C@@H]1CNC(=O)c1cc(Cl)c(NC)cc1OC	10.1016/s0960-894x(99)00086-4
		9977532	117968	1	None	-9999	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL326454	117968	1	None	-9999	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		71457844	90851	0	None	-2137	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	429	6	0	4	5.1	COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207638	90851	0	None	-2137	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	429	6	0	4	5.1	COc1ccccc1N1CCN(Cc2cc(CN3CCCCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		44381117	64605	0	None	-120	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL167032	64605	0	None	-120	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	415	7	2	4	3.6	COc1cc(NC(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		9909648	212352	3	None	-134	11	Human	6.4	pKi	=	6.4	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.7b00151
		CHEMBL81330	212352	3	None	-134	11	Human	6.4	pKi	=	6.4	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	340	4	0	3	3.7	Fc1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	10.1021/acs.jmedchem.7b00151
		161379	193994	8	None	-79	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
		CHEMBL492418	193994	8	None	-79	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
		681	8247	72	None	-97	38	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		940	8247	72	None	-97	38	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		947	8247	72	None	-97	38	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		CHEMBL59	8247	72	None	-97	38	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		DB00988	8247	72	None	-97	38	Rat	6.4	pKi	=	6.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991034o
		10085358	116996	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
		CHEMBL323771	116996	0	None	-	1	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
		76328713	113181	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		CHEMBL3115576	113181	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		CHEMBL3139455	113181	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		1816	9318	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		4205	9318	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		7241	9318	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		CHEMBL654	9318	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		DB00370	9318	102	None	-323	18	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	10.1021/jm049632c
		21119297	98975	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425373	98975	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		44299940	107744	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		CHEMBL294186	107744	0	None	-	1	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	309	1	1	3	3.3	COc1cc2c(cc1O)[C@@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		44415535	86925	0	None	42	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213388	86925	0	None	42	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	5	4.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		24900557	205166	0	None	-17	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	409	4	1	7	3.4	CNc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
		CHEMBL576756	205166	0	None	-17	4	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	409	4	1	7	3.4	CNc1ncc2c(n1)CC(CN1CCC(c3noc4cc(F)ccc34)CC1)CC2=O	10.1016/j.bmcl.2009.09.041
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00302-9
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(02)00316-5
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm015522j
		44393403	71852	0	None	-416	6	Pig	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1016/j.bmcl.2004.05.052
		CHEMBL182379	71852	0	None	-416	6	Pig	6.4	pKi	=	6.4	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1016/j.bmcl.2004.05.052
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(98)00692-1
		135398737	7745	93	None	-37	90	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		38	7745	93	None	-37	90	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		722	7745	93	None	-37	90	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		CHEMBL42	7745	93	None	-37	90	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		DB00363	7745	93	None	-37	90	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm060166w
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0009989
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(99)00540-5
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmc.2009.05.015
		57393628	76088	0	None	-1230	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	5.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928137	76088	0	None	-1230	5	Pig	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	5.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(OCCOCCOCCOCCOc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(01)00814-9
		135398737	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		38	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		722	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		CHEMBL42	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		DB00363	7745	93	None	-204	90	Bovine	6.4	pKi	=	6.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/s0960-894x(00)00405-4
		44339984	174576	0	None	-186	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL430522	174576	0	None	-186	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		53362841	70735	0	None	-16	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
		CHEMBL1806870	70735	0	None	-16	4	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells after 50 mins by beta liquid scintillation counter	ChEMBL	412	5	1	3	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OC(=O)NCc2ccccc2)c1-3	10.1021/jm200347t
		53328719	73246	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL1852163	73246	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		CHEMBL3216980	73246	0	None	-20	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	386	4	4	6	2.4	CN1CCc2cc(SC[C@H](N)C(=O)O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.ejmech.2011.04.028
		70690651	83336	0	None	-3	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]21	10.1016/j.ejmech.2012.07.025
		CHEMBL2062848	83336	0	None	-3	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	364	7	1	3	3.8	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]21	10.1016/j.ejmech.2012.07.025
		44588932	19380	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL1186975	19380	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL485041	19380	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	349	2	3	3	4.2	Oc1cc2c(c(-c3ccc(F)cc3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		68663	34055	23	None	-6	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
		CHEMBL136711	34055	23	None	-6	4	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	10.1016/j.bmc.2007.07.018
		2337	10030	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		50	10030	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		5002	10030	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		CHEMBL716	10030	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		DB01224	10030	77	None	-53	62	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	10.1021/jm030480f
		1016	10519	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2561	10519	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		2733526	10519	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		5384	10519	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		CHEMBL83	10519	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		DB00675	10519	78	None	-29	35	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	nan
		44582140	189277	0	None	-10	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	7	0	4	3.3	COc1cccc(N2CCN(CCCCN3CCc4ccccc4C3=O)CC2)c1	10.1016/j.bmcl.2009.01.067
		CHEMBL478688	189277	0	None	-10	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	393	7	0	4	3.3	COc1cccc(N2CCN(CCCCN3CCc4ccccc4C3=O)CC2)c1	10.1016/j.bmcl.2009.01.067
		44327167	16150	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
		CHEMBL111393	16150	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
		CHEMBL544319	16150	0	None	-3	4	Rat	6.4	pKi	=	6.4	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	371	4	0	4	4.2	O=C1CC(CN2CCC(C(=O)c3ccc(F)cc3)CC2)Cc2sccc21	10.1021/jm981094e
		10516949	54693	0	None	2	2	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1cc2c3c(c1)Oc1ccccc1CC3N(C)CC2	10.1021/jm991034o
		CHEMBL154948	54693	0	None	2	2	Rat	5.4	pKi	=	5.4	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1cc2c3c(c1)Oc1ccccc1CC3N(C)CC2	10.1021/jm991034o
		117774121	139225	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	384	4	1	6	3.0	Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C#N)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697588	139225	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	384	4	1	6	3.0	Cc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C#N)n(C)c(=O)[nH]c1=O	nan
		9945168	130443	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	325	2	0	5	3.0	CN1CCN(C2=Cn3c(C=O)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
		CHEMBL362060	130443	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	325	2	0	5	3.0	CN1CCN(C2=Cn3c(C=O)ccc3Sc3ccccc32)CC1	10.1021/jm0309811
		76325150	113199	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		CHEMBL3115575	113199	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		CHEMBL3139554	113199	0	None	-4265	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1cccc(I)c1)CC2	10.1021/jm401384w
		135398737	7745	93	None	-83	90	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		38	7745	93	None	-83	90	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		722	7745	93	None	-83	90	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		CHEMBL42	7745	93	None	-83	90	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		DB00363	7745	93	None	-83	90	Rat	7.4	pKi	=	7.4	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm00043a008
		124618	205159	7	None	134	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	243	1	4	4	1.9	NCC1c2cc(O)ccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
		CHEMBL57672	205159	7	None	134	2	Rat	7.4	pKi	=	7.4	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	243	1	4	4	1.9	NCC1c2cc(O)ccc2-c2c1ccc(O)c2O	10.1021/jm00160a018
		86764319	139242	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697604	139242	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	0	5	4.2	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)ncc(=O)n1C	nan
		127047221	146708	0	None	-1	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		CHEMBL3799593	146708	0	None	-1	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		127046950	146823	0	None	-23	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800303	146823	0	None	-23	6	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	437	12	4	6	4.0	COc1cc(CCNC[C@H](O)c2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		25071385	165936	0	None	-208	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4098236	165936	0	None	-208	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(C=O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		681	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		940	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		947	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		CHEMBL59	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		DB00988	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm9708700
		681	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		940	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		947	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		CHEMBL59	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		DB00988	8247	72	None	-23	38	Bovine	5.4	pKi	=	5.4	Binding	Binding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retinaBinding affinity for dopamine D1-like receptor labelled with [3H]SCH-23390 in retina	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/s0960-894x(00)00633-8
		10333842	105207	1	None	-31	8	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
		CHEMBL27559	105207	1	None	-31	8	Human	5.4	pKi	=	5.4	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/ml1001689
		44448070	101668	0	None	3	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		CHEMBL254147	101668	0	None	3	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		25071691	118564	0	None	-2818	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		CHEMBL3287403	118564	0	None	-2818	5	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		72545239	99903	0	None	-426	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	499	14	0	9	3.0	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCOCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443006	99903	0	None	-426	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	499	14	0	9	3.0	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCOCCOCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		21119297	98975	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425373	98975	0	None	1	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	325	3	0	4	3.4	COc1ccc2c(c1)CC1c3cc(OC)c(OC)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		25186021	194803	0	None	-1318	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	10.1021/jm800689g
		CHEMBL497574	194803	0	None	-1318	3	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	10.1021/jm800689g
		10333842	105207	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
		CHEMBL27559	105207	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390Binding affinity against Dopamine receptor D1 from rat brain corpus striatal preparations using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00402a024
		10333842	105207	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		CHEMBL27559	105207	1	None	-50	8	Rat	6.4	pKi	=	6.4	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		1530	8963	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		3827	8963	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		7206	8963	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		CHEMBL534	8963	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		DB00920	8963	50	None	-53	21	Human	6.4	pKi	=	6.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	nan
		76328713	113181	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		CHEMBL3115576	113181	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		CHEMBL3139455	113181	0	None	-251	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1I)CC2	10.1021/jm401384w
		71722291	109237	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL2397385	109237	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL3040059	109237	0	None	-3	3	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	423	2	3	4	5.3	CN1CCc2ccc(Cc3ccc(O)c4ccccc34)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		11712530	194669	0	None	-41686	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1021/jm800689g
		CHEMBL496531	194669	0	None	-41686	4	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	10.1021/jm800689g
		135398737	7745	93	None	-44	90	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		38	7745	93	None	-44	90	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		722	7745	93	None	-44	90	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		CHEMBL42	7745	93	None	-44	90	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		DB00363	7745	93	None	-44	90	Human	7.4	pKi	=	7.4	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2020.127563
		44415849	148191	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	509	3	1	6	5.1	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL384069	148191	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	509	3	1	6	5.1	COc1cccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
		86764104	139259	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697622	139259	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		74223775	136209	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	316	3	1	4	4.4	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		CHEMBL3671288	136209	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	316	3	1	4	4.4	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1	nan
		681	8247	72	None	-23	38	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		940	8247	72	None	-23	38	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		947	8247	72	None	-23	38	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		CHEMBL59	8247	72	None	-23	38	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		DB00988	8247	72	None	-23	38	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in bovine striatum	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/j.bmc.2013.01.065
		137657115	166534	0	None	-173	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4105030	166534	0	None	-173	5	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(/C=N/O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		10831251	169952	0	None	4	2	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL41809	169952	0	None	4	2	Rat	6.4	pKi	=	6.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	3	3	4	4.3	CC(C)CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		44340084	15860	0	None	-2238	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL109912	15860	0	None	-2238	4	Bovine	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		25131137	194326	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	558	9	2	5	7.4	Nc1nc2c(s1)C[C@@H](N(CCC1CCCCC1)CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
		CHEMBL494509	194326	0	None	-3	2	Rat	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	558	9	2	5	7.4	Nc1nc2c(s1)C[C@@H](N(CCC1CCCCC1)CC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
		681	8247	72	None	-97	38	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		940	8247	72	None	-97	38	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		947	8247	72	None	-97	38	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		CHEMBL59	8247	72	None	-97	38	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		DB00988	8247	72	None	-97	38	Rat	5.4	pKi	=	5.4	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm00160a016
		70696888	83348	0	None	-8	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
		CHEMBL2062860	83348	0	None	-8	3	Human	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@H]1[C@H]2CN(Cc3ccccc3)[C@H](c3ccccc3)[C@H]2[C@@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
		44329039	214916	0	None	-56	3	Bovine	4.4	pKi	=	4.4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL98072	214916	0	None	-56	3	Bovine	4.4	pKi	=	4.4	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
		14198585	107578	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL293158	107578	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		14198585	107578	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00118a012
		CHEMBL293158	107578	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00118a012
		44320076	213205	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL87910	213205	0	None	3	2	Rat	6.4	pKi	=	6.4	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	285	3	3	4	2.3	NC[C@@H]1OC(Cc2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		11282465	199897	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL522746	199897	1	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		11406615	92678	0	None	-162	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	388	5	2	4	4.1	S=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
		CHEMBL2298832	92678	0	None	-162	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	388	5	2	4	4.1	S=c1[nH]c2ccc(OCCN3CCN(c4ccccc4Cl)CC3)cc2[nH]1	10.1007/s00044-012-0055-5
		14198585	107578	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL293158	107578	1	None	1	4	Rat	6.4	pKi	=	6.4	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		14198585	107578	1	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00129a006
		CHEMBL293158	107578	1	None	-1	4	Human	6.4	pKi	=	6.4	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00129a006
		44415759	148466	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	3	1	5	6.5	CC(C)(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL385590	148466	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	535	3	1	5	6.5	CC(C)(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		681	8247	72	None	-154	38	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		940	8247	72	None	-154	38	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		947	8247	72	None	-154	38	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		CHEMBL59	8247	72	None	-154	38	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		DB00988	8247	72	None	-154	38	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in LHD1 cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm301258w
		44276551	104151	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL26965	104151	0	None	10	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	310	2	3	4	3.0	CCCc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		10333842	105207	1	None	-31	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmc.2008.08.056
		CHEMBL27559	105207	1	None	-31	8	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]8OH-DPAT from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmc.2008.08.056
		10588327	20553	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL1195441	20553	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
		CHEMBL554571	20553	0	None	22	2	Rat	7.4	pKi	=	7.4	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@H]1c3cscc3CN[C@@H]1CC2	10.1021/jm970038v
		72699903	121976	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)Cl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344469	121976	0	None	-2	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	3	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)Cl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		122197088	139193	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	362	3	1	5	3.4	[C-]#[N+]c1c(C)ccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		CHEMBL3697556	139193	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	362	3	1	5	3.4	[C-]#[N+]c1c(C)ccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		71563082	94056	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2331599	94056	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		9908125	126122	0	None	-20	4	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c2c1	10.1021/jm0009989
		CHEMBL344270	126122	0	None	-20	4	Bovine	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)c2c1	10.1021/jm0009989
		11016418	112899	0	None	-7244	9	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	488	6	0	7	4.2	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		CHEMBL313424	112899	0	None	-7244	9	Rat	5.4	pKi	=	5.4	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	488	6	0	7	4.2	Cn1cnc(-c2ccc3c(c2)c(C2CCN(CCN4CCOC4=O)CC2)cn3-c2ccc(F)cc2)n1	10.1021/jm020938y
		71456046	90850	0	None	-2951	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	389	6	0	4	4.2	COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207637	90850	0	None	-2951	7	Pig	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	389	6	0	4	4.2	COc1ccccc1N1CCN(Cc2cc(CN(C)C)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		127045853	146571	0	None	-17782	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3798748	146571	0	None	-17782	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	492	12	4	7	3.6	COc1cc(CCNC[C@H](O)c2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		137655795	165361	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	453	7	2	7	3.0	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4091933	165361	0	None	-1778	6	Human	5.4	pKi	=	5.4	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	453	7	2	7	3.0	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5c4OCCO5)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		12050201	209653	0	None	-31	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	7	1	5	5.3	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL62624	209653	0	None	-31	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	7	1	5	5.3	COc1ccc(Br)cc1-c1nc(CNC2CCN(Cc3ccccc3)CC2)cs1	10.1016/s0960-894x(00)00405-4
		44319361	212499	0	None	-7	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL82527	212499	0	None	-7	4	Bovine	5.4	pKi	=	5.4	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	337	4	0	4	3.4	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CS2)cc1	10.1016/s0960-894x(01)00484-x
		44264629	104141	0	None	-316	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4c3ccc3ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL269576	104141	0	None	-316	4	Bovine	4.4	pKi	=	4.4	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4c3ccc3ccccc34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		72545011	99901	0	None	-3162	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	411	8	0	7	2.9	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443004	99901	0	None	-3162	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	411	8	0	7	2.9	COc1ccccc1N1CCN(Cc2cn(-c3ccc(OCCF)cc3)nn2)CC1	10.1016/j.bmcl.2013.09.026
		42606339	24703	0	None	-97	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1	10.1021/jm100835q
		CHEMBL1259241	24703	0	None	-97	5	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	397	5	1	4	4.3	Cc1ccc(CNCC2(F)CCN(C(=O)c3csc4ccccc34)CC2)nc1	10.1021/jm100835q
		71734126	97829	0	None	-4466	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
		CHEMBL2397391	97829	0	None	-4466	4	Pig	4.4	pKi	=	4.4	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	378	9	1	4	3.7	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccn3n2)CC1	10.1021/jm400520c
		2812	11551	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		CHEMBL104	11551	101	None	-32	34	Human	5.4	pKi	=	5.4	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	nan
		127027737	144765	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	342	6	1	4	2.2	O=C(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		CHEMBL3764420	144765	0	None	-4	2	Rat	6.4	pKi	=	6.4	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysisDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum incubated for 15 mins by liquid scintillation counting analysis	ChEMBL	342	6	1	4	2.2	O=C(NCCCN1CCN(c2ccc(F)cc2)CC1)c1ccncc1	10.1016/j.ejmech.2016.01.021
		44399174	74787	0	None	-870	4	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatumInhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatum	ChEMBL	449	6	0	5	3.0	O=C1C2C3C=CC(C3)C2C(=O)N1OCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm050246k
		CHEMBL191226	74787	0	None	-870	4	Rat	5.4	pKi	=	5.4	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatumInhibition of [3H]SCH-23,390 binding to Dopamine D1 receptor from rat striatum	ChEMBL	449	6	0	5	3.0	O=C1C2C3C=CC(C3)C2C(=O)N1OCCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1021/jm050246k
		44282127	123347	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL1743804	123347	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL33644	123347	0	None	-1	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	309	3	0	3	4.0	COc1cc2c(cc1OC)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		3083157	69810	2	None	-229	2	Rat	6.3	pKi	=	6.3	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	277	2	1	2	3.7	C=CCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		CHEMBL1788212	69810	2	None	-229	2	Rat	6.3	pKi	=	6.3	Binding	Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	277	2	1	2	3.7	C=CCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm00105a005
		15711852	20111	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL1192193	20111	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		CHEMBL543389	20111	0	None	5	3	Goldfish	6.3	pKi	=	6.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	317	5	2	3	4.3	CCCNC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(C)c2O	10.1021/jm00114a002
		176	7186	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2157	7186	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		2566	7186	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		CHEMBL633	7186	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		DB01118	7186	66	None	-4	31	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	nan
		145968810	171817	0	None	-120	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
		CHEMBL4226226	171817	0	None	-120	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
		15937731	124268	6	None	5	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	211	0	1	2	2.1	CN1CCc2cc(O)c(Cl)cc2CC1	10.1016/S0960-894X(00)80155-9
		CHEMBL340006	124268	6	None	5	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	211	0	1	2	2.1	CN1CCc2cc(O)c(Cl)cc2CC1	10.1016/S0960-894X(00)80155-9
		24766199	104300	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm701045j
		CHEMBL270426	104300	0	None	-1	5	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm701045j
		24766199	104300	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm9015763
		CHEMBL270426	104300	0	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	281	1	1	3	3.2	COc1cc2c3c(c1)-c1c(O)cccc1C[C@H]3N(C)CC2	10.1021/jm9015763
		44301054	202927	0	None	-218	6	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
		CHEMBL56118	202927	0	None	-218	6	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	266	3	1	3	2.2	N#Cc1c[nH]c(CN2CCN(c3ccccc3)CC2)c1	10.1016/s0960-894x(02)00316-5
		25139481	191619	0	None	-32	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	392	10	1	2	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1	10.1021/jm800895v
		CHEMBL485227	191619	0	None	-32	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	392	10	1	2	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCCCC1	10.1021/jm800895v
		25186569	183761	0	None	-45708	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
		CHEMBL462508	183761	0	None	-45708	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
		122177643	127989	0	None	-2884	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	632	20	3	9	5.1	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1	10.1021/jm501889t
		CHEMBL3577344	127989	0	None	-2884	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	632	20	3	9	5.1	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)CCc3ccc(O)c4[nH]c(=O)ccc34)cc2OC)nn1	10.1021/jm501889t
		3198	212292	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL1201049	212292	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		CHEMBL808	212292	76	None	-31	34	Human	5.3	pKi	=	5.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	nan
		10803661	117699	0	None	-2	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	1	1	3	3.3	CC(=O)c1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL326159	117699	0	None	-2	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	293	1	1	3	3.3	CC(=O)c1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		25141534	63009	0	None	-2238	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
		CHEMBL1627305	63009	0	None	-2238	7	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	460	7	3	4	3.8	O=C(NCCC(O)CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
		76314268	113211	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3115577	113211	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		CHEMBL3139633	113211	0	None	-2630	4	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	450	3	1	4	3.5	Oc1ccc2c(c1)O[C@@H](CN1CCN(c3ccc(I)cc3)CC1)CC2	10.1021/jm401384w
		1353	8692	93	None	-74	85	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		3559	8692	93	None	-74	85	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		86	8692	93	None	-74	85	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		CHEMBL54	8692	93	None	-74	85	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		DB00502	8692	93	None	-74	85	Rat	6.3	pKi	=	6.3	Binding	Tested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligandTested for binding affinity towards rat striatal dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00047a010
		10042602	73064	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1016/j.bmcl.2004.06.005
		CHEMBL184770	73064	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1016/j.bmcl.2004.06.005
		3106	55294	16	None	-87	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		CHEMBL15564	55294	16	None	-87	3	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	237	7	2	3	2.8	CCCN(CCC)CCc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		10042602	73064	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1007/s00044-012-0055-5
		CHEMBL184770	73064	0	None	-912	5	Human	5.3	pKi	=	5.3	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	335	4	1	4	2.9	Cc1cccc(N2CCN(CCc3ccc4[nH]nnc4c3)CC2)c1C	10.1007/s00044-012-0055-5
		10683943	121159	0	None	-81	3	Rat	5.3	pKi	=	5.3	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	277	1	0	2	3.6	CC(=O)c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL333134	121159	0	None	-81	3	Rat	5.3	pKi	=	5.3	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	277	1	0	2	3.6	CC(=O)c1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		135398745	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
		47	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
		CHEMBL715	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
		DB00334	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2020.127563
		1353	8692	93	None	-74	85	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		3559	8692	93	None	-74	85	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		86	8692	93	None	-74	85	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		CHEMBL54	8692	93	None	-74	85	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		DB00502	8692	93	None	-74	85	Rat	7.3	pKi	=	7.3	Binding	Binding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligandBinding affinity was measured against dopamine receptor D1 in rat using [3H]SCH-23390 as radioligand	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00039a008
		46869265	23029	0	None	-4	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2012.08.058
		CHEMBL1224527	23029	0	None	-4	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	295	1	3	3	3.1	Oc1ccc2c(c1O)C[C@@H](c1ccccc1)[C@@H]1CCNC[C@@H]21	10.1016/j.bmc.2012.08.058
		44415839	86672	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212402	86672	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415345	88089	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
		CHEMBL215885	88089	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
		44415517	86852	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213083	86852	0	None	19	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	463	2	1	5	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(F)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		44415345	88089	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
		CHEMBL215885	88089	0	None	64	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
		11186086	70147	0	None	-12	4	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	313	1	0	3	3.2	CN1CCN(C2=Cc3cc(Cl)ccc3Cn3cccc32)CC1	10.1021/jm049629t
		CHEMBL179557	70147	0	None	-12	4	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	313	1	0	3	3.2	CN1CCN(C2=Cc3cc(Cl)ccc3Cn3cccc32)CC1	10.1021/jm049629t
		45482153	204817	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	502	9	1	7	3.9	COc1ccc(-n2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
		CHEMBL574030	204817	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	502	9	1	7	3.9	COc1ccc(-n2cc(C(=O)NCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)nn2)cc1	10.1016/j.bmc.2009.06.041
		137644833	164918	0	None	-87	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4087187	164918	0	None	-87	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	408	9	0	7	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3nc(C=O)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		44436606	98772	0	None	-1445	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL241641	98772	0	None	-1445	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	505	7	1	3	5.7	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
		44339992	115961	0	None	-501	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL321492	115961	0	None	-501	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		9977532	117968	1	None	-9999	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL326454	117968	1	None	-9999	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		71734129	97836	0	None	-10964	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
		CHEMBL2397480	97836	0	None	-10964	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
		137654675	165413	0	None	-1230	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	433	7	2	7	2.9	O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
		CHEMBL4092441	165413	0	None	-1230	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	433	7	2	7	2.9	O=c1ccc2c(N3CCN(CCCCOc4ccn5nccc5c4)CC3)ccc(O)c2[nH]1	10.1021/acs.jmedchem.7b00363
		11652518	172711	0	None	-16	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4cccnc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL425064	172711	0	None	-16	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1ccc(N2CCN(Cc3cn4cccnc4n3)CC2)cc1	10.1021/jm060166w
		44329090	214805	0	None	-26	3	Bovine	4.3	pKi	=	4.3	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL97436	214805	0	None	-26	3	Bovine	4.3	pKi	=	4.3	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2c(C=O)ccc2C1	10.1016/s0960-894x(01)00564-9
		134	9292	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		1775	9292	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		9681	9292	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		CHEMBL1065	9292	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		DB00247	9292	24	None	-263	67	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	nan
		14787976	203759	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL56666	203759	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		44320303	170746	0	None	2	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL420788	170746	0	None	2	2	Rat	5.3	pKi	=	5.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	315	4	3	4	2.9	C#CCNC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		11358377	209118	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	295	0	0	3	3.5	CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3	10.1016/j.bmc.2009.08.028
		CHEMBL610449	209118	0	None	-2	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	295	0	0	3	3.5	CN1CCCc2cc3c(cc2-c2ccccc2CC1)OCO3	10.1016/j.bmc.2009.08.028
		44415646	146556	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	635	4	1	7	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OC(F)(F)O4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL379862	146556	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	635	4	1	7	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OC(F)(F)O4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		10264969	55069	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
		CHEMBL155352	55069	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
		15696487	170578	1	None	9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL420604	170578	1	None	9	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	263	1	3	4	2.4	NC[C@@H]1OC2(CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		15654858	109077	0	None	2	2	Rat	4.3	pKi	=	4.3	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3cccnc3N(C=O)c3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL303435	109077	0	None	2	2	Rat	4.3	pKi	=	4.3	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	321	1	0	5	2.0	CN1CCN(C2=Nc3cccnc3N(C=O)c3ccccc32)CC1	10.1021/jm00067a009
		44415807	148414	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccccc1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL385295	148414	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccccc1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		15111052	19547	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1187965	19547	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL534678	19547	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	279	3	1	2	3.6	C=CCN1CCc2ccc(O)cc2C(c2ccccc2)C1	10.1021/jm00079a008
		156017805	184605	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	343	4	1	3	4.2	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4643886	184605	0	None	5	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	343	4	1	3	4.2	C=CCN1CCc2cc(OC)c(O)cc2C(c2ccccc2Cl)C1	10.1016/j.bmcl.2020.127305
		21171	193755	33	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
		CHEMBL490533	193755	33	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
		46893146	68381	0	None	-3981	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771110	68381	0	None	-3981	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	475	8	0	5	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		53363202	70630	0	None	-26	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	961	28	0	15	8.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(C5CCCCC5)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803055	70630	0	None	-26	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	961	28	0	15	8.7	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(C5CCCCC5)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		122191605	130498	0	None	-23	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	426	7	2	3	4.2	Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1	10.1021/acsmedchemlett.5b00131
		CHEMBL3622097	130498	0	None	-23	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	426	7	2	3	4.2	Brc1ccc(NCCN2CCN(CCc3c[nH]c4ccccc34)CC2)cc1	10.1021/acsmedchemlett.5b00131
		44319370	113824	0	None	-1	4	Bovine	6.3	pKi	=	6.3	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
		CHEMBL315564	113824	0	None	-1	4	Bovine	6.3	pKi	=	6.3	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	443	5	0	5	3.8	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)[C@@H](C)O1	10.1016/s0960-894x(01)00484-x
		10264969	55069	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
		CHEMBL155352	55069	0	None	-6	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
		137634397	162884	0	None	-11748	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
		CHEMBL4063145	162884	0	None	-11748	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	480	8	3	10	2.2	O=C1COc2c(N3CCN(CCCCOc4ccn5ncc(/C=N/O)c5c4)CC3)ccc(O)c2N1	10.1016/j.bmc.2017.08.037
		24824062	162491	0	None	-79	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1	10.1021/jm701375u
		CHEMBL405260	162491	0	None	-79	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	354	6	0	5	3.0	FCCOc1ccccc1N1CCN(Cc2cc3ccccn3n2)CC1	10.1021/jm701375u
		44372312	60559	0	None	-43	3	Bovine	5.3	pKi	=	5.3	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
		CHEMBL160396	60559	0	None	-43	3	Bovine	5.3	pKi	=	5.3	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	356	4	1	5	2.8	OCc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
		11492	44279	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
		59111271	44279	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
		CHEMBL145584	44279	61	None	-2	2	Human	4.3	pKi	=	4.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	137	2	2	2	0.9	NCCc1cccc(O)c1	10.1021/jm9800292
		42606573	24618	0	None	-81	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1	10.1021/jm100835q
		CHEMBL1258999	24618	0	None	-81	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig cortex membranes	ChEMBL	381	5	1	4	3.9	Cc1ccc(CNCC2(F)CCN(C(=O)c3coc4ccccc34)CC2)nc1	10.1021/jm100835q
		136043859	145683	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	430	2	1	4	5.9	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL378301	145683	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	430	2	1	4	5.9	Cc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(C)c1	10.1016/j.bmcl.2006.06.034
		10618131	35276	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	354	6	2	4	3.4	CN(C)CCCCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL137583	35276	0	None	-	1	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	354	6	2	4	3.4	CN(C)CCCCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		10518820	117177	0	None	-31	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	307	2	0	3	3.7	COc1c(C(C)=O)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL324372	117177	0	None	-31	3	Rat	5.3	pKi	=	5.3	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23,390 displacement.	ChEMBL	307	2	0	3	3.7	COc1c(C(C)=O)ccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		12049521	209970	0	None	-13	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	427	5	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL64288	209970	0	None	-13	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	427	5	0	5	4.4	COc1ccc(Br)cc1-c1nc(CN2CCN(c3ccccc3)CC2)co1	10.1016/s0960-894x(00)00405-4
		117773325	139199	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	5	2.7	Cc1cc(Oc2ncccc2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697562	139199	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	341	3	1	5	2.7	Cc1cc(Oc2ncccc2F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44582517	188418	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.3	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL477446	188418	0	None	-4	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	431	5	0	3	4.3	O=C1c2ccccc2CCCN1CCCN1CCN(c2cccc(C(F)(F)F)c2)CC1	10.1016/j.bmcl.2009.01.067
		154726792	183363	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4475406	183363	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4597530	183363	1	None	-1202	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	489	13	1	4	5.9	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)C[C@@H]1C[C@H]1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		9841398	106295	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
		CHEMBL28338	106295	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm00018a002
		9841398	106295	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL28338	106295	4	None	-3	4	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		44276552	106656	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		CHEMBL285924	106656	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	298	1	3	5	2.1	COc1ccc2c(n1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1016/s0960-894x(99)00214-0
		1353	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		3559	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		86	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		CHEMBL54	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		DB00502	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	Compound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assayCompound was tested for the binding affinity against human cloned Dopamine receptor D1 by radioligand ([3H]SCH-23390) binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm9601720
		44415822	175621	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(F)cc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL437917	175621	0	None	33	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	531	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(F)cc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		10409038	92017	0	None	-41	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		CHEMBL225853	92017	0	None	-41	4	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	405	2	2	5	3.6	COc1cc2c(cc1O)C[C@H]1c3c(c(Br)c(O)c(OC)c3-2)CCN1C	10.1021/jm060959i
		118709176	120201	0	None	-34	4	Pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1106	29	0	14	11.8	O=C(CCc1cn(CCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318849	120201	0	None	-34	4	Pig	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1106	29	0	14	11.8	O=C(CCc1cn(CCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		9952858	14326	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
		CHEMBL108764	14326	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
		9952858	14326	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL108764	14326	0	None	117	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	8	1	3	5.2	CN(C)CCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		167715	9651	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		969	9651	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		CHEMBL225230	9651	14	None	-194	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		11504230	84992	0	None	-870	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		CHEMBL210567	84992	0	None	-870	7	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		10830557	38075	0	None	-4	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(F)cc4)CC3)c2c1	10.1021/jm0009989
		CHEMBL140165	38075	0	None	-4	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(F)cc4)CC3)c2c1	10.1021/jm0009989
		46905072	16949	0	None	-28	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL1159663	16949	0	None	-28	2	Human	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	323	6	1	2	4.5	CCCN(CCc1ccc(C)cc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		25131138	194328	0	None	-72	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	480	8	2	6	5.4	CCCN(CC[C@H]1CC[C@H](NC(=O)c2cc3ccccc3o2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL494511	194328	0	None	-72	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	480	8	2	6	5.4	CCCN(CC[C@H]1CC[C@H](NC(=O)c2cc3ccccc3o2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		49782602	23941	0	None	-162	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	583	6	1	3	7.4	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1256169	23941	0	None	-162	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	583	6	1	3	7.4	O=C(CCCN1CCC(O)(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		57390117	76074	0	None	-346	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.2	CCOCCOCc1ccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
		CHEMBL1928123	76074	0	None	-346	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	455	13	1	6	3.2	CCOCCOCc1ccc(C(=O)NCCCN2CCN(c3ccccc3OC)CC2)cc1	10.1016/j.bmc.2011.10.063
		70690653	83349	0	None	-32	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
		CHEMBL2062861	83349	0	None	-32	3	Human	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	376	5	1	3	4.0	OC[C@@H]1[C@@H]2CN(Cc3ccccc3)[C@@H](c3ccccc3)[C@@H]2[C@H]1N1CCCCC1	10.1016/j.ejmech.2012.07.025
		45481890	205795	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	9	2	9	4.4	COc1ccccc1N1CCN(CCCn2cc(CN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL585742	205795	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	9	2	9	4.4	COc1ccccc1N1CCN(CCCn2cc(CN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		228	7233	28	None	-35	23	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		33	7233	28	None	-35	23	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		6005	7233	28	None	-35	23	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		CHEMBL53	7233	28	None	-35	23	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		DB00714	7233	28	None	-35	23	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2013.05.014
		15225750	148163	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	383	1	1	5	3.2	CC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL383869	148163	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	383	1	1	5	3.2	CC(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		57391216	76943	0	None	-23	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	332	6	0	5	2.9	Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940416	76943	0	None	-23	8	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	332	6	0	5	2.9	Fc1ccc(SCCCN2CCN(c3ncccn3)CC2)cc1	10.1016/j.bmc.2014.04.026
		44304603	209917	0	None	-43	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
		CHEMBL64139	209917	0	None	-43	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	471	8	1	5	5.2	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)cs1	10.1016/s0960-894x(00)00405-4
		42625211	63013	0	None	-81	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	450	10	3	5	3.3	CCCOc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
		CHEMBL1627309	63013	0	None	-81	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	450	10	3	5	3.3	CCCOc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm900095y
		14138285	151933	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
		CHEMBL3912178	151933	6	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)C1Cc3cc(O)c(O)cc3CN1CC2	nan
		5016	115946	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL32145	115946	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		CHEMBL544114	115946	8	None	125	2	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	373	3	2	3	4.0	C=CCN1CCc2c(cc(O)c(O)c2Br)C(c2ccccc2)C1	10.1021/jm00116a004
		74223772	136200	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3671279	136200	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	2	4	4.0	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		86767101	136214	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	393	4	1	5	4.4	Cc1ncnc(N2CC(F)C2)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671292	136214	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	393	4	1	5	4.4	Cc1ncnc(N2CC(F)C2)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1F	nan
		6852376	98374	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
		CHEMBL1467585	98374	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
		CHEMBL24077	98374	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
		CHEMBL503958	98374	13	None	-3	5	Human	8.3	pKi	=	8.3	Binding	Binding affinity against Dopamine receptor D1 in rat radioligandBinding affinity against Dopamine receptor D1 in rat radioligand	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00170a025
		15711869	20112	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL1192194	20112	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		CHEMBL543390	20112	0	None	6	6	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	333	2	2	3	3.5	NC[C@@H]1O[C@H](c2ccccc2)Cc2c1ccc(Br)c2O	10.1021/jm00114a002
		15937729	124940	0	None	301	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	277	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL340855	124940	0	None	301	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	277	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2C(C2=CCCC2)C1	10.1016/S0960-894X(00)80155-9
		70690500	82848	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		CHEMBL2057455	82848	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	341	3	1	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	nan
		44401164	76591	0	None	-19	9	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL193639	76591	0	None	-19	9	Human	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.5	CN(C)C[C@H]1CC2c3ccccc3Sc3ccc(F)cc3[C@H]2O1	10.1021/jm049632c
		15115525	116467	0	None	134	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	509	4	2	8	5.0	CN1CCc2cc(Br)c(O)cc2C(c2ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc2)C1	10.1021/jm00115a012
		CHEMBL322760	116467	0	None	134	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	509	4	2	8	5.0	CN1CCc2cc(Br)c(O)cc2C(c2ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc2)C1	10.1021/jm00115a012
		134155502	158207	0	None	20	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	341	3	2	5	3.2	CCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3961827	158207	0	None	20	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	341	3	2	5	3.2	CCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		15696466	11039	0	None	208	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00114a002
		CHEMBL100572	11039	0	None	208	2	Rat	8.3	pKi	=	8.3	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1O[C@H](C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00114a002
		44320050	113608	0	None	138	3	Rat	8.3	pKi	=	8.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL314459	113608	0	None	138	3	Rat	8.3	pKi	=	8.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	277	2	3	4	2.6	NC[C@@H]1OC(C2CCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		86764106	139211	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	4	4.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697574	139211	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	355	3	1	4	4.5	Cc1cc(Oc2nccc(C)c2Cl)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		44356291	29507	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	269	1	3	3	2.7	C[C@@]1(N)Cc2cc(O)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm960318v
		CHEMBL132766	29507	0	None	-	1	Rat	8.3	pKi	=	8.3	Binding	Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.Binding affinity at Dopamine receptor D1 in rat neostriatum by [3H]-SCH- 23390 displacement.	ChEMBL	269	1	3	3	2.7	C[C@@]1(N)Cc2cc(O)c(O)cc2[C@@]1(C)c1ccccc1	10.1021/jm960318v
		162643108	188435	0	None	83	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	335	1	1	3	5.0	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4776090	188435	0	None	83	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	335	1	1	3	5.0	Cc1ccc2c(c1)N=C(C1=C[C@H](C)N(C)CC1)c1cc(F)ccc1N2	10.1016/j.bmcl.2020.127563
		71563083	94347	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		CHEMBL2335737	94347	0	None	2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in CHO cell membranes after 60 mins	ChEMBL	343	1	2	3	3.9	Cc1cc2c(cc1O)[C@H]1C[C@@](O)(c3ccc(Cl)cc3)CCN1CC2	10.1016/j.bmcl.2012.12.046
		10742	10389	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
		1225	10389	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
		CHEMBL35354	10389	31	None	-2	8	Human	8.3	pKi	=	8.3	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at Dopamine receptor D1	ChEMBL	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	10.1021/jm00116a004
		5290	206812	40	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)C1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		CHEMBL595489	206812	40	None	17	3	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)C1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		46231769	207836	0	None	371	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)C4CC4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL602659	207836	0	None	371	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	396	2	2	3	4.3	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)C4CC4)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		15937718	122011	0	None	48	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	251	2	1	2	3.2	C=CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL334728	122011	0	None	48	2	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	251	2	1	2	3.2	C=CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		10732044	91188	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2114440	91188	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2219804	91188	0	None	41	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	287	0	3	4	3.0	Cc1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		46231771	207759	0	None	107	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		CHEMBL602052	207759	0	None	107	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	420	3	2	4	3.7	CCS(=O)(=O)Nc1cccc2c1CC[C@H]1[C@H]2c2cc(O)c(Cl)cc2CCN1C	10.1016/j.bmcl.2009.12.100
		11727683	68823	0	None	-1	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	345	1	0	4	4.2	CN1CCCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		CHEMBL177455	68823	0	None	-1	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	345	1	0	4	4.2	CN1CCCN(C2=Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm0309811
		6917970	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
		8370	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
		CHEMBL487387	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.ejmech.2016.09.036
		6917970	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
		8370	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
		CHEMBL487387	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in CHO cells by scintillation counting	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2009.08.028
		161665	179364	35	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL448891	179364	35	None	1	5	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1OC)[C@@H]1Cc3ccc(O)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		2389	10104	118	None	-346	66	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		5073	10104	118	None	-346	66	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		96	10104	118	None	-346	66	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		CHEMBL85	10104	118	None	-346	66	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		DB00734	10104	118	None	-346	66	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm800689g
		2726	7706	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		621	7706	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		83	7706	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		CHEMBL71	7706	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		DB00477	7706	68	None	-18	72	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm00118a012
		71109989	160554	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		CHEMBL3982119	160554	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(cc1OC)[C@@H]1Cc3c(OC)ccc(OC)c3CN1CC2	nan
		2407	10145	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		59227	10145	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		941	10145	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		CHEMBL1303	10145	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		DB05271	10145	76	None	-60	7	Bovine	6.3	pKi	=	6.3	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	ChEMBL	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	10.1021/jm020990u
		3716121	90856	16	None	-1258	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	332	4	0	3	4.1	COc1ccccc1N1CCN(Cc2ccc3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207643	90856	16	None	-1258	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	332	4	0	3	4.1	COc1ccccc1N1CCN(Cc2ccc3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		145986441	173951	0	None	-147	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	432	7	2	4	3.7	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Br)cc1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4291172	173951	0	None	-147	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	432	7	2	4	3.7	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Br)cc1)CC2	10.1021/acsmedchemlett.8b00229
		71454294	90852	0	None	-1096	7	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	431	6	0	5	4.0	COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207639	90852	0	None	-1096	7	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	431	6	0	5	4.0	COc1ccccc1N1CCN(Cc2cc(CN3CCOCC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		1577	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		2537	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		5355	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		5501	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		643497	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		688272	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		958	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		960	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		CHEMBL196677	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		CHEMBL26	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		CHEMBL267044	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		DB00391	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		DB16021	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(99)00086-4
		1577	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		2537	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		5355	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		5501	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		643497	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		688272	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		958	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		960	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		CHEMBL196677	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		CHEMBL26	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		CHEMBL267044	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		DB00391	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		DB16021	10475	110	None	-69	20	Bovine	4.3	pKi	=	4.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	10.1016/s0960-894x(00)00405-4
		10827222	13757	1	None	-457	5	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligandBinding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand	ChEMBL	288	3	0	2	3.6	C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1	10.1021/jm950721m
		CHEMBL108463	13757	1	None	-457	5	Rat	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligandBinding affinity against Dopamine receptor D1 in rat brain membrane using [3H]-SCH- 23390 as radioligand	ChEMBL	288	3	0	2	3.6	C(#Cc1cccnc1)CCN1CC=C(c2ccccc2)CC1	10.1021/jm950721m
		45481875	204898	0	None	-12	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL574595	204898	0	None	-12	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		10939222	211181	1	None	-1000	5	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	445	8	1	4	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(Br)cc2)CC1	10.1016/0960-894X(95)00011-H
		CHEMBL71960	211181	1	None	-1000	5	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissueBinding affinity towards D1 receptor using [3H]-SCH- 23390 in rat striatal tissue	ChEMBL	445	8	1	4	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(Br)cc2)CC1	10.1016/0960-894X(95)00011-H
		44415825	87891	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	573	4	1	5	6.8	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccccc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL215641	87891	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	573	4	1	5	6.8	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccccc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		44415786	86825	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	549	6	1	5	6.9	CCC(CC)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212966	86825	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	549	6	1	5	6.9	CCC(CC)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		25141538	63015	0	None	-2089	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	440	8	3	5	2.6	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm900095y
		CHEMBL1627311	63015	0	None	-2089	3	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	440	8	3	5	2.6	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3cc(F)ccc3[nH]2)CC1	10.1021/jm900095y
		154705884	183142	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4469584	183142	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595726	183142	1	None	-15	6	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		11522476	81298	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	311	2	0	3	3.3	COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2	10.1021/jm050846j
		CHEMBL202924	81298	0	None	4	3	Human	6.3	pKi	=	6.3	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	311	2	0	3	3.3	COc1cc2c(cc1OC)Cc1ccccc1CCN(C)CC2	10.1021/jm050846j
		162660874	188662	0	None	9	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4779001	188662	0	None	9	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
		86764103	139215	13	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		CHEMBL3697578	139215	13	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	10.1021/acsmedchemlett.9b00050
		75201899	178695	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
		CHEMBL4469983	178695	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assayDisplacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay	ChEMBL	351	3	1	5	4.1	Cc1n[nH]c(=O)c(C)c1-c1ccc(Oc2nccc3occc23)cc1F	10.1021/acsmedchemlett.9b00050
		44415838	145858	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL378648	145858	0	None	3	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	504	2	1	6	5.0	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415560	87145	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	4	1	6	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Oc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL214407	87145	0	None	8	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	4	1	6	6.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Oc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		9883454	120743	0	None	-2	2	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL332600	120743	0	None	-2	2	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		10758745	107209	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115373	107209	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL290438	107209	0	None	18	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		9883454	120743	0	None	-2	2	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL332600	120743	0	None	-2	2	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat tissue homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		56833378	75108	0	None	-281	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1121	39	2	14	10.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN(CCC)C5Cc6ccccc6C5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		CHEMBL1916549	75108	0	None	-281	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	1121	39	2	14	10.7	CCCN(CCCCNC(=O)c1ccc(OCCCc2cn(CCCCCCCCn3cc(CCCOc4ccc(C(=O)NCCCCN(CCC)C5Cc6ccccc6C5)cc4OC)nn3)nn2)c(OC)c1)C1Cc2ccccc2C1	10.1021/jm2009919
		10665598	41857	1	None	-30	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4Cl)CC3)c2c1	10.1021/jm0009989
		CHEMBL143355	41857	1	None	-30	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccccc4Cl)CC3)c2c1	10.1021/jm0009989
		164609519	191230	0	None	-426	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2	10.1016/j.bmcl.2021.128047
		CHEMBL4846574	191230	0	None	-426	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1cccc(C#N)c1)CC2	10.1016/j.bmcl.2021.128047
		44454685	101828	0	None	-63	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1cccc(CN2CCN(c3ccc(Cl)cc3)CC2)c1	10.1016/j.bmcl.2007.12.026
		CHEMBL255163	101828	0	None	-63	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	348	6	0	3	4.0	FCCOc1cccc(CN2CCN(c3ccc(Cl)cc3)CC2)c1	10.1016/j.bmcl.2007.12.026
		44380715	65787	0	None	-269	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL169222	65787	0	None	-269	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
		155569483	182978	0	None	-154	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	2	2	5	2.9	CCNc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
		CHEMBL4593728	182978	0	None	-154	2	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	303	2	2	5	2.9	CCNc1nc(C#Cc2ccc(Cl)s2)nc2[nH]cnc12	10.1039/C8MD00317C
		14787977	205661	2	None	1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
		CHEMBL58422	205661	2	None	1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
		14787976	203759	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL56666	203759	0	None	1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		44405965	81788	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	449	5	2	5	3.2	O=c1[nH]c2[nH]c(-c3ccccc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		CHEMBL203362	81788	0	None	-3	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	449	5	2	5	3.2	O=c1[nH]c2[nH]c(-c3ccccc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		135398745	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		47	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		CHEMBL715	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		DB00334	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmc.2008.06.030
		44320092	168666	0	None	39	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL415080	168666	0	None	39	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	349	2	3	4	3.2	NC[C@@H]1OC(c2ccc(Br)cc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		57401820	76936	0	None	-6	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	364	6	0	3	4.8	Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940409	76936	0	None	-6	7	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	364	6	0	3	4.8	Fc1ccc(SCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		135398745	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
		47	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
		CHEMBL715	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
		DB00334	9688	112	None	-26	65	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation countingDisplacement of [3H]SCH23390 from human dopamine D1 receptor by liquid scintillation counting	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1016/j.bmcl.2014.07.018
		10592479	107041	0	None	48	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL288846	107041	0	None	48	2	Rat	7.3	pKi	=	7.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	2	3	4	3.9	CC(C)Cc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		21302490	119582	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
		CHEMBL3233142	119582	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
		CHEMBL3306803	119582	32	None	-8	9	Human	7.3	pKi	=	7.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	10.1021/jm401958n
		74223829	136226	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	351	3	1	5	4.5	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1Cl	nan
		CHEMBL3671303	136226	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	351	3	1	5	4.5	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1Cl	nan
		70686343	82847	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057454	82847	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	371	4	1	6	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(O)c(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		56971028	76020	0	None	-3	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	392	8	1	6	2.5	CCOc1ccccc1N1CCN(CCCN/C(=N\C#N)c2ccccn2)CC1	10.1016/j.ejmech.2011.11.023
		CHEMBL1927090	76020	0	None	-3	2	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation countingDisplacement of [3H]SCH-23390 from rat corpora striatum dopamine D1 receptor after 15 mins by liquid scintillation counting	ChEMBL	392	8	1	6	2.5	CCOc1ccccc1N1CCN(CCCN/C(=N\C#N)c2ccccn2)CC1	10.1016/j.ejmech.2011.11.023
		15711865	19947	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		CHEMBL1190906	19947	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		CHEMBL541838	19947	0	None	1	2	Goldfish	7.3	pKi	=	7.3	Binding	In vitro inhibition of dopamine stimulated adenylate cyclaseIn vitro inhibition of dopamine stimulated adenylate cyclase	ChEMBL	255	2	2	3	2.7	NC[C@@H]1O[C@H](c2ccccc2)Cc2c(O)cccc21	10.1021/jm00114a002
		117774289	139190	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.1	CCc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		CHEMBL3697553	139190	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	351	4	1	5	3.1	CCc1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		164585473	191341	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		CHEMBL4848380	191341	0	None	2	5	Human	6.3	pKi	=	6.3	Binding	Binding affinity to D1 receptor (unknown origin)Binding affinity to D1 receptor (unknown origin)	ChEMBL	503	5	1	2	7.2	O=CN1CCC(c2ccc(-c3cc(C(=O)O)cc4cc(-c5ccc(C(F)(F)F)cc5)ccc34)cc2)CC1	10.1021/acs.jmedchem.1c00164
		44393372	73100	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	549	8	1	5	4.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3s2)CC1	10.1016/j.bmcl.2004.05.052
		CHEMBL184993	73100	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	549	8	1	5	4.8	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3s2)CC1	10.1016/j.bmcl.2004.05.052
		1257607	162091	2	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	433	4	0	5	4.2	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL403032	162091	2	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	433	4	0	5	4.2	COc1cc2c(cc1OC)-c1c(OC)c(OC)c(Br)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		45268293	202914	0	None	-20	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	408	4	1	7	1.4	Cn1c(N2CCOCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL561123	202914	0	None	-20	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	408	4	1	7	1.4	Cn1c(N2CCOCC2)nc2c(CN3CCN(c4ccccc4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		10854877	148793	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL38757	148793	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	343	4	3	4	4.4	CCCCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		44454711	104295	0	None	-3311	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2cccc(OCCF)c2)CC1	10.1016/j.bmcl.2007.12.026
		CHEMBL270408	104295	0	None	-3311	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	344	7	0	4	3.4	COc1ccccc1N1CCN(Cc2cccc(OCCF)c2)CC1	10.1016/j.bmcl.2007.12.026
		10001207	172100	0	None	-114	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL423440	172100	0	None	-114	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	402	6	1	3	3.7	COc1ccc(Br)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		44567597	176243	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	592	5	4	8	5.5	CN1CCc2cc(OCCOc3cc4c5c(c3)-c3c(ccc(O)c3O)C[C@H]5N(C)CC4)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		CHEMBL442926	176243	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	592	5	4	8	5.5	CN1CCc2cc(OCCOc3cc4c5c(c3)-c3c(ccc(O)c3O)C[C@H]5N(C)CC4)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		90644063	118812	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289648	118812	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		14198596	108420	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL299056	108420	0	None	2	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		135221	151997	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		CHEMBL3912606	151997	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	357	3	2	6	2.8	COc1cc2c(c(OC)c1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		90644063	118812	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289648	118812	0	None	-22	10	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	327	6	0	3	3.7	Cc1ccc(N2CCN(CCCCc3ccc(F)cc3)CC2)nc1	10.1016/j.bmc.2014.04.026
		10826687	57723	0	None	-4	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1ccc2c(c1)CC1c3c(cccc3O2)CCN1C	10.1021/jm991034o
		CHEMBL157799	57723	0	None	-4	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	0	3	3.6	COc1ccc2c(c1)CC1c3c(cccc3O2)CCN1C	10.1021/jm991034o
		44569447	185534	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	323	2	0	4	3.4	COc1cc2c3c(c1)-c1c(cccc1OC(C)=O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.11.025
		CHEMBL468677	185534	0	None	-3	2	Rat	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	323	2	0	4	3.4	COc1cc2c3c(c1)-c1c(cccc1OC(C)=O)C[C@H]3N(C)CC2	10.1016/j.bmcl.2008.11.025
		1152279	37509	7	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL1395394	37509	7	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(O)c3CN1CC2	10.1016/j.bmc.2012.12.016
		135398737	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		38	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		722	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		CHEMBL42	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		DB00363	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm0002432
		135398737	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		38	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		722	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		CHEMBL42	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		DB00363	7745	93	None	-44	90	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	nan
		228	7233	28	None	-30	23	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		33	7233	28	None	-30	23	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		6005	7233	28	None	-30	23	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		CHEMBL53	7233	28	None	-30	23	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		DB00714	7233	28	None	-30	23	Rat	7.3	pKi	=	7.3	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00160a018
		11782988	18413	0	None	-1	2	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL118092	18413	0	None	-1	2	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		14198586	208612	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		CHEMBL60706	208612	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Binding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity of compound towards dopamine (D1) receptor using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		14198586	208612	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00118a012
		CHEMBL60706	208612	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00118a012
		14198586	208612	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Compound was evaluated for the binding affinity against dopamine (D1) receptorCompound was evaluated for the binding affinity against dopamine (D1) receptor	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		CHEMBL60706	208612	0	None	2	2	Rat	7.3	pKi	=	7.3	Binding	Compound was evaluated for the binding affinity against dopamine (D1) receptorCompound was evaluated for the binding affinity against dopamine (D1) receptor	ChEMBL	287	2	1	2	3.8	CN1CCc2cc(Cl)c(O)cc2C1Cc1ccccc1	10.1021/jm00051a008
		11782988	18413	0	None	-1	2	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		CHEMBL118092	18413	0	None	-1	2	Rat	7.3	pKi	=	7.3	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	1	0	4	4.0	CN1CCCN(C2Cn3cccc3Sc3ccc(Cl)cc32)CC1	10.1021/jm010982y
		86767100	131216	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)c(F)c1F	nan
		CHEMBL3639701	131216	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)c(F)c1F	nan
		44320256	213092	0	None	5	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL87172	213092	0	None	5	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	361	4	3	4	3.9	NC[C@@H]1OC(C(c2ccccc2)c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		188442	94284	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3O)C[C@@H]21	10.1016/j.bmc.2012.12.016
		CHEMBL2334887	94284	5	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1O)CCN1Cc3c(ccc(OC)c3O)C[C@@H]21	10.1016/j.bmc.2012.12.016
		15467371	107784	0	None	-912	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
		CHEMBL294458	107784	0	None	-912	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	351	4	1	4	3.4	N#CC(C#N)=Cc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
		10831735	38529	0	None	-2511	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)cc4)CC3)cc2c1	10.1021/jm0009989
		CHEMBL140594	38529	0	None	-2511	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(Cl)cc4)CC3)cc2c1	10.1021/jm0009989
		10567430	126071	1	None	-1445	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2cc(CN3CCN(c4ccccc4)CC3)[nH]c2c1	10.1021/jm0009989
		CHEMBL343880	126071	1	None	-1445	4	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	316	3	1	3	3.4	N#Cc1ccc2cc(CN3CCN(c4ccccc4)CC3)[nH]c2c1	10.1021/jm0009989
		44340097	16212	0	None	-4365	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL111749	16212	0	None	-4365	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.6	CNc1cc(OC)c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		44567595	182056	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	327	3	3	5	2.2	CN1CCc2cc(OCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		CHEMBL457275	182056	0	None	-15	2	Mouse	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	327	3	3	5	2.2	CN1CCc2cc(OCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		137645830	164631	0	None	-131	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	424	7	1	8	2.8	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2	10.1021/acs.jmedchem.7b00363
		CHEMBL4083727	164631	0	None	-131	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	424	7	1	8	2.8	Oc1ccc(N2CCN(CCCCOc3ccn4nccc4c3)CC2)c2c1OCCO2	10.1021/acs.jmedchem.7b00363
		11615489	76218	1	None	-588	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@H]1CCn2nccc2C1	10.1021/jm101639t
		CHEMBL193337	76218	1	None	-588	4	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@H]1CCn2nccc2C1	10.1021/jm101639t
		14787976	203759	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00170a025
		CHEMBL56666	203759	0	None	-1	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@@H]21	10.1021/jm00170a025
		14787977	205661	2	None	-1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
		CHEMBL58422	205661	2	None	-1	3	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
		156012880	184221	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	364	4	0	5	3.4	C#CCOc1c(OC)cc2c3c1-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4638749	184221	0	None	-2	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	364	4	0	5	3.4	C#CCOc1c(OC)cc2c3c1-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		10809188	16047	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL110847	16047	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		CHEMBL540822	16047	0	None	-83	4	Rat	5.3	pKi	=	5.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	370	5	0	5	3.7	COc1ccccc1N1CCN(CCC2CCc3sccc3C2=O)CC1	10.1021/jm981094e
		150	9287	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		1764	9287	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		8226	9287	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		CHEMBL1201356	9287	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		DB00353	9287	21	None	-43	16	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	nan
		135398737	7745	93	None	-83	90	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		38	7745	93	None	-83	90	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		722	7745	93	None	-83	90	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		CHEMBL42	7745	93	None	-83	90	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		DB00363	7745	93	None	-83	90	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm049632c
		44415824	87987	0	None	13	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	3	1	5	5.5	CCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL215842	87987	0	None	13	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	493	3	1	5	5.5	CCN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		117772871	139258	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697621	139258	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	4	1	5	3.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		86767099	136212	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1cc(F)c(Oc2nccc3[nH]ccc23)cc1F	nan
		CHEMBL3671290	136212	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	352	3	1	4	4.7	Cc1ncnc(C)c1-c1cc(F)c(Oc2nccc3[nH]ccc23)cc1F	nan
		135398737	7745	93	None	-44	90	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		38	7745	93	None	-44	90	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		722	7745	93	None	-44	90	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		CHEMBL42	7745	93	None	-44	90	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		DB00363	7745	93	None	-44	90	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1021/jm030480f
		57390118	76077	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928126	76077	0	None	-616	5	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	953	32	2	13	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		12997400	107781	7	None	-53	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	241	3	1	2	2.3	c1ccc(N2CCN(Cc3ccc[nH]3)CC2)cc1	10.1016/s0960-894x(02)00316-5
		CHEMBL294394	107781	7	None	-53	4	Bovine	5.3	pKi	=	5.3	Binding	Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1Ability to displace [3H]SCH-23,390 radioligand from bovine Dopamine receptor D1	ChEMBL	241	3	1	2	2.3	c1ccc(N2CCN(Cc3ccc[nH]3)CC2)cc1	10.1016/s0960-894x(02)00316-5
		122132	209343	17	None	-87	4	Human	5.3	pKi	=	5.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm9800292
		CHEMBL611801	209343	17	None	-87	4	Human	5.3	pKi	=	5.3	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm9800292
		44454735	102092	0	None	-2951	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	374	8	0	5	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
		CHEMBL256492	102092	0	None	-2951	5	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	374	8	0	5	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
		25131136	194290	0	None	-97	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	504	9	2	5	6.2	CCCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		CHEMBL494308	194290	0	None	-97	2	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	504	9	2	5	6.2	CCCCN(CC[C@H]1CC[C@H](NC(=O)c2ccc3ccccc3c2)CC1)[C@H]1CCc2nc(N)sc2C1	10.1021/jm800471h
		49782837	24357	0	None	-44	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	472	6	0	3	6.0	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1258154	24357	0	None	-44	5	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	472	6	0	3	6.0	O=C(CCCN1CCN(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		137645574	164582	0	None	-5754	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	462	7	3	6	3.1	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		CHEMBL4083239	164582	0	None	-5754	6	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	462	7	3	6	3.1	O=C1CCc2ccc(OCCCCN3CCN(c4ccc(O)c5[nH]c(=O)ccc45)CC3)cc2N1	10.1021/acs.jmedchem.7b00363
		72545009	99899	0	None	-109	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443002	99899	0	None	-109	5	Pig	4.3	pKi	=	4.3	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3F)nn2)CC1	10.1016/j.bmcl.2013.09.026
		145970938	171935	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	233	5	1	2	3.4	CCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4228054	171935	0	None	-4	5	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	233	5	1	2	3.4	CCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		11698732	79520	0	None	2	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccc(Cl)cc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		CHEMBL199876	79520	0	None	2	4	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccc(Cl)cc3)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		44304643	210054	0	None	-8	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	8	0	5	5.1	COc1ccc(Br)cc1-c1nc(CN(C)C[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL64668	210054	0	None	-8	4	Bovine	5.3	pKi	=	5.3	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	8	0	5	5.1	COc1ccc(Br)cc1-c1nc(CN(C)C[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		3168	16034	92	None	-89	22	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		CHEMBL1108	16034	92	None	-89	22	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	nan
		162665267	188961	0	None	21	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.6	CN1CCC(C2=Nc3cc(Cl)ccc3Nc3ccccc32)=CC1(C)C	10.1016/j.bmcl.2020.127563
		CHEMBL4782694	188961	0	None	21	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	351	1	1	3	5.6	CN1CCC(C2=Nc3cc(Cl)ccc3Nc3ccccc32)=CC1(C)C	10.1016/j.bmcl.2020.127563
		1353	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		3559	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		86	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		CHEMBL54	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		DB00502	8692	93	None	-38	85	Human	7.3	pKi	=	7.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	nan
		117774669	139257	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.0	CCn1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)c(C)c(=O)[nH]c1=O	nan
		CHEMBL3697620	139257	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	4.0	CCn1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)c(C)c(=O)[nH]c1=O	nan
		71454927	91367	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
		CHEMBL2158636	91367	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
		CHEMBL2221040	91367	0	None	-10	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	311	1	4	4	3.0	Oc1ccc([C@H]2CN[C@@H]3CCc4cc(O)c(O)cc4[C@H]3C2)cc1	10.1016/j.bmc.2012.08.058
		10641637	125558	0	None	-19	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)cc4)CC3)c2c1	10.1021/jm0009989
		CHEMBL342001	125558	0	None	-19	4	Bovine	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]cc(CN3CCN(c4ccc(Cl)cc4)CC3)c2c1	10.1021/jm0009989
		118709172	120196	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	493	8	0	4	6.6	Cc1ccc(C(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318844	120196	0	None	-10	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	493	8	0	4	6.6	Cc1ccc(C(=O)OC2(c3ccc(Cl)cc3)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	10.1016/j.bmcl.2014.06.079
		10336538	8406	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
		974	8406	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
		CHEMBL310843	8406	50	None	-5495	8	Bovine	5.3	pKi	=	5.3	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm015522j
		10336538	8406	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
		974	8406	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
		CHEMBL310843	8406	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1016/j.bmcl.2007.12.026
		44436597	98575	0	None	-251	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL241210	98575	0	None	-251	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	477	5	1	3	4.9	O=C(NCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(C#Cc2ccccc2)cc1	10.1016/j.bmc.2007.08.038
		11559581	85193	0	None	-2754	6	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	3	0	5	3.4	Clc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL211135	85193	0	None	-2754	6	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	361	3	0	5	3.4	Clc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
		11654739	183627	0	None	-20417	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
		CHEMBL461236	183627	0	None	-20417	4	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	10.1021/jm800689g
		71734031	97835	0	None	-22908	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
		CHEMBL2397479	97835	0	None	-22908	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	394	9	1	3	5.2	C#CC1=CC[C@H](N(CCC)CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm400520c
		10336538	8406	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
		974	8406	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
		CHEMBL310843	8406	50	None	-5495	8	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/jm701375u
		10336538	8406	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
		974	8406	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
		CHEMBL310843	8406	50	None	-5495	8	Human	5.3	pKi	=	5.3	Binding	Inhibition of human dopamine D1 receptorInhibition of human dopamine D1 receptor	ChEMBL	326	3	0	4	3.3	Clc1ccc(cc1)N1CCN(CC1)Cc1cc2n(n1)cccc2	10.1021/acs.jmedchem.7b00151
		44537919	204915	0	None	-28	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL574700	204915	0	None	-28	3	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCc2cn(CCCN3CCc4cc(O)c(O)cc4C(c4ccccc4C)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		10811026	35320	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	9	2	3	4.3	O=CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL137636	35320	0	None	3	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	400	9	2	3	4.3	O=CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		2398	7741	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		2801	7741	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		701	7741	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		CHEMBL415	7741	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		DB01242	7741	62	None	-11	29	Human	6.3	pKi	=	6.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	nan
		6852376	98374	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL1467585	98374	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL24077	98374	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		CHEMBL503958	98374	13	None	-3	5	Human	7.3	pKi	=	7.3	Binding	Binding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cellsBinding affinity against cloned human Dopamine receptor D1 using [125I]-SCH 23982 as radioligand transfected in HEK cells	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00018a002
		44415802	86982	0	None	14	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213668	86982	0	None	14	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415383	88226	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	5	1	6	5.4	COc1ccc(CCC(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1Cl	10.1016/j.bmcl.2006.06.022
		CHEMBL215950	88226	0	None	10	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	537	5	1	6	5.4	COc1ccc(CCC(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1Cl	10.1016/j.bmcl.2006.06.022
		25110708	19381	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL1186978	19381	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		CHEMBL485207	19381	0	None	6	3	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	381	2	3	3	5.2	Oc1cc2c(c(-c3ccc4ccccc4c3)c1O)CCNCC2c1ccccc1	10.1016/j.bmc.2008.09.049
		130442561	173672	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4286110	173672	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	368	4	0	5	5.8	COc1ccc2cnccc2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		44276405	106885	0	None	6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
		CHEMBL287513	106885	0	None	6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	322	0	3	4	2.9	Oc1cc2c(cc1O)[C@H]1c3cc4c(nc3CN[C@@H]1CC2)CCCC4	10.1016/s0960-894x(99)00214-0
		44412191	145153	0	None	-107	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1	10.1016/j.bmcl.2006.02.075
		CHEMBL377200	145153	0	None	-107	4	Pig	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	332	4	0	4	3.5	Cc1c(CN2CCN(c3ccccc3)CC2)cnn1-c1ccccc1	10.1016/j.bmcl.2006.02.075
		11071135	214787	0	None	-2570	8	Rat	5.3	pKi	=	5.3	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	500	6	0	6	4.6	CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O	10.1021/jm020938y
		CHEMBL97333	214787	0	None	-2570	8	Rat	5.3	pKi	=	5.3	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	ChEMBL	500	6	0	6	4.6	CN1CCC(CCN2CCC(c3cn(-c4ccc(F)cc4)c4ccc(-c5ncn(C)n5)cc34)CC2)C1=O	10.1021/jm020938y
		11661609	86468	0	None	-5623	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	414	4	0	5	3.7	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1	10.1021/jm060166w
		CHEMBL211539	86468	0	None	-5623	4	Pig	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	414	4	0	5	3.7	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1	10.1021/jm060166w
		44339879	179061	0	None	-186	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL447476	179061	0	None	-186	4	Bovine	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)N[C@H]2CCCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(03)00678-4
		44327153	115987	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
		CHEMBL321682	115987	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
		CHEMBL558817	115987	0	None	-3	4	Rat	6.3	pKi	=	6.3	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine 1 (D1) receptor in rat striatal membrane.	ChEMBL	385	5	0	4	4.6	O=C(c1ccc(F)cc1)C1CCN(CCC2CCc3ccsc3C2=O)CC1	10.1021/jm981094e
		10738274	171670	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(Br)cc(OC)c2C1Cc1ccccc1O	10.1021/jm991034o
		CHEMBL422169	171670	0	None	-2	2	Rat	5.3	pKi	=	5.3	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	4	1	3	4.3	CCN1CCc2cc(Br)cc(OC)c2C1Cc1ccccc1O	10.1021/jm991034o
		145982261	173511	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
		CHEMBL4283176	173511	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	347	3	0	5	5.5	Cc1cc(Oc2nccc3occc23)ccc1-c1ccnn1C(C)(C)C	10.1021/acs.jmedchem.8b01622
		155195311	181126	0	None	-1778	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assayDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay	ChEMBL	433	7	3	5	3.4	C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1	10.1021/acsmedchemlett.9b00660
		CHEMBL4551160	181126	0	None	-1778	5	Human	5.3	pKi	=	5.3	Binding	Displacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assayDisplacement of [3H]-SCH23390 from human D1 receptor expressed in HEK293 cells after 60 mins by microbeta counting based assay	ChEMBL	433	7	3	5	3.4	C[C@H]1CO[C@@H](c2ccc(N)nc2)CN1C[C@H]1C[C@@H]1CCNC(=O)c1cc2ccccc2[nH]1	10.1021/acsmedchemlett.9b00660
		24949693	189083	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	10.1021/jm800176x
		CHEMBL478413	189083	0	None	-7244	3	Rat	5.3	pKi	=	5.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	10.1021/jm800176x
		14198593	205453	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		CHEMBL57988	205453	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00051a008
		36791366	94279	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL2334880	94279	1	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		14198593	205453	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00118a012
		CHEMBL57988	205453	1	None	4	2	Rat	6.3	pKi	=	6.3	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CNCC2c1ccccc1	10.1021/jm00118a012
		44405985	176339	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccccc3Cl)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		CHEMBL443567	176339	0	None	-8	3	Human	6.3	pKi	=	6.3	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	483	5	2	5	3.8	O=c1[nH]c2[nH]c(-c3ccccc3Cl)cc2c(=O)n1CCN1CCN(c2ccccc2Cl)CC1	10.1016/j.bmcl.2005.09.027
		122132	209343	17	None	4	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm00160a018
		CHEMBL611801	209343	17	None	4	4	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	207	1	2	3	1.5	CN(C)C1CCc2cc(O)c(O)cc2C1	10.1021/jm00160a018
		11720302	173037	0	None	-301	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	503	7	1	3	5.2	O=C(NCCCCN1CCN(c2cccc(F)c2F)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
		CHEMBL426863	173037	0	None	-301	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	503	7	1	3	5.2	O=C(NCCCCN1CCN(c2cccc(F)c2F)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm060138d
		10939167	16272	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
		CHEMBL112065	16272	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
		CHEMBL129483	16272	0	None	-165	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	443	9	1	4	4.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3ccccc3)cc2)CC1	10.1021/jm101639t
		44454710	162445	0	None	-478	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	378	7	0	4	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
		CHEMBL404888	162445	0	None	-478	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	378	7	0	4	4.0	COc1cc(CN2CCN(c3ccc(Cl)cc3)CC2)ccc1OCCF	10.1016/j.bmcl.2007.12.026
		137631036	167930	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		CHEMBL4060837	167930	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		CHEMBL4117325	167930	0	None	-28	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	420	6	1	5	2.6	O=C(NCCCCN1CC[N+]2(CCOc3ccccc32)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		44415623	145032	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	599	4	1	7	6.4	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL377043	145032	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	599	4	1	7	6.4	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3cccc4c3OCO4)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		44316058	212316	0	None	-64	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		CHEMBL80974	212316	0	None	-64	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		10316297	130827	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
		CHEMBL363124	130827	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1016/j.bmcl.2004.06.005
		10316297	130827	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
		CHEMBL363124	130827	0	None	-549	5	Human	5.2	pKi	=	5.2	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	357	4	1	4	3.5	c1ccc2c(N3CCN(CCc4ccc5[nH]nnc5c4)CC3)cccc2c1	10.1007/s00044-012-0055-5
		53946796	74541	1	None	-5248	2	Rat	4.2	pKi	=	4.2	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
		CHEMBL1907969	74541	1	None	-5248	2	Rat	4.2	pKi	=	4.2	Binding	In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.In vitro affinity against Dopamine receptor D1 using [3H]SCH-23390 radioligand in rat striatal homogenate.	ChEMBL	235	3	2	3	2.7	CCCN1CCC[C@H](c2ccc(O)c(O)c2)C1	10.1021/jm00160a016
		44427970	159389	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	325	2	0	3	3.7	COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
		CHEMBL397207	159389	0	None	-1	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	325	2	0	3	3.7	COc1cc2c(cc1OC)Cc1ccccc1CCCN(C)CC2	10.1021/jm070388+
		156010592	183907	0	None	14	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	376	4	1	4	3.4	C#CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4633772	183907	0	None	14	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	376	4	1	4	3.4	C#CCOc1c(OC)cc2c3c1-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		86764321	139250	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	399	5	1	5	4.3	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C1CC1	nan
		CHEMBL3697612	139250	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	399	5	1	5	4.3	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C1CC1	nan
		117773598	139253	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.7	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2C)c(C)c(=O)[nH]c1=O	nan
		CHEMBL3697615	139253	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	4	1	5	3.7	CCn1c(-c2ccc(Oc3ncccc3Cl)cc2C)c(C)c(=O)[nH]c1=O	nan
		164626655	193372	0	None	-16	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2	10.1016/j.bmcl.2021.128047
		CHEMBL4878587	193372	0	None	-16	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	441	7	1	5	4.1	COc1cc2c(cc1OC)CN(Cc1ccccc1CNC(=O)c1ccc(C#N)cc1)CC2	10.1016/j.bmcl.2021.128047
		44287454	20000	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL1191276	20000	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL542351	20000	0	None	-1	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1csc2c1CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		1353	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		3559	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		86	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		CHEMBL54	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		DB00502	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat brainDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat brain	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmc.2007.07.018
		2389	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		5073	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		96	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		CHEMBL85	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		DB00734	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1016/j.bmc.2008.06.030
		54580906	68379	0	None	-2754	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771109	68379	0	None	-2754	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	459	8	0	5	4.6	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccco4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		57391895	76076	0	None	-301	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928125	76076	0	None	-301	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	925	30	2	13	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		3156990	14902	22	None	-28	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		CHEMBL109173	14902	22	None	-28	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1cccn1C1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(99)00540-5
		25139478	191735	0	None	-446	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	510	10	0	4	7.5	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
		CHEMBL485384	191735	0	None	-446	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	510	10	0	4	7.5	CCCN(CCCCn1cc(-c2ccc(-c3ccccc3)cc2)nn1)C1CC=C(C#C[Si](C)(C)C)CC1	10.1021/jm800895v
		15467369	107705	0	None	-6165	3	Bovine	4.2	pKi	=	4.2	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccccc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
		CHEMBL293956	107705	0	None	-6165	3	Bovine	4.2	pKi	=	4.2	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1ccc(CN2CCN(c3ccccc3)CC2)[nH]1	10.1016/s0960-894x(99)00302-9
		136043854	86962	0	None	-20	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	460	2	1	6	5.1	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc4c(c3)OCCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
		CHEMBL213577	86962	0	None	-20	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	460	2	1	6	5.1	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc4c(c3)OCCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
		77974401	120737	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	252	1	1	2	2.9	CN1CCc2ccc(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325920	120737	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	252	1	1	2	2.9	CN1CCc2ccc(N)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		154727843	183212	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		CHEMBL4448853	183212	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		CHEMBL4596221	183212	1	None	-5	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	486	13	0	6	5.6	CCN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1c1cc(F)ccc1OCCF	10.1021/acs.jmedchem.9b01835
		71086428	158332	0	None	-66	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3963122	158332	0	None	-66	2	Mouse	5.2	pKi	=	5.2	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	373	6	0	5	2.9	Clc1cncc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		3108374	98752	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
		CHEMBL2414990	98752	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
		107715	207724	22	None	-144	20	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL1255837	207724	22	None	-144	20	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		CHEMBL601773	207724	22	None	-144	20	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	nan
		57401819	76935	0	None	-75	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	346	6	0	2	4.6	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL1940408	76935	0	None	-75	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	346	6	0	2	4.6	Fc1ccc(CCCCN2CCN(c3ccc(Cl)cc3)CC2)cc1	10.1016/j.bmc.2014.04.026
		23364995	120197	0	None	-13	4	Pig	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	417	7	0	4	5.0	CC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318845	120197	0	None	-13	4	Pig	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	417	7	0	4	5.0	CC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		86764104	139259	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697622	139259	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	4	4.5	Cc1cc(Oc2ncccc2C(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		156020558	184825	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	1	2	3	3.5	CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		CHEMBL4647167	184825	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	1	2	3	3.5	CN1CCc2cc(O)c(O)cc2C(c2ccccc2Br)C1	10.1016/j.bmcl.2020.127305
		44436617	98335	0	None	-20	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	481	9	1	4	4.8	COc1ccccc1N1CCN(CCCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
		CHEMBL240584	98335	0	None	-20	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	481	9	1	4	4.8	COc1ccccc1N1CCN(CCCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
		49782604	24295	0	None	-19	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	379	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		CHEMBL1257927	24295	0	None	-19	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	379	6	1	3	4.9	Cc1ccc(C)c(C(=O)CCCN2CCC(O)(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		49782836	24324	0	None	-58	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	456	6	0	3	5.5	O=C(CCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
		CHEMBL1258036	24324	0	None	-58	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	456	6	0	3	5.5	O=C(CCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1ccc(F)cc1	10.1021/jm100899z
		24841480	190678	0	None	-2951	20	Human	5.2	pKi	=	5.2	Binding	Antagonist activity at dopamine D1 receptor (unknown origin) by PDSP assayAntagonist activity at dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		CHEMBL481153	190678	0	None	-2951	20	Human	5.2	pKi	=	5.2	Binding	Antagonist activity at dopamine D1 receptor (unknown origin) by PDSP assayAntagonist activity at dopamine D1 receptor (unknown origin) by PDSP assay	ChEMBL	340	3	0	4	4.5	O=C(OCCN1CCCC1)N1c2ccccc2Sc2ccccc21	10.1016/j.bmcl.2013.04.082
		44436603	151994	0	None	-269	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
		CHEMBL391257	151994	0	None	-269	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	467	8	1	4	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cccc(C#Cc3ccccc3)c2)CC1	10.1016/j.bmc.2007.08.038
		11655570	86501	0	None	-11220	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	462	4	0	5	3.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1	10.1021/jm060166w
		CHEMBL211590	86501	0	None	-11220	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	462	4	0	5	3.6	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1	10.1021/jm060166w
		45267409	202940	0	None	-1513	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)ncn23)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL561262	202940	0	None	-1513	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	351	4	0	6	2.7	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)ncn23)CC1	10.1016/j.bmc.2009.05.015
		71212556	150340	0	None	-120	6	Human	6.2	pKi	=	6.2	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		CHEMBL3899169	150340	0	None	-120	6	Human	6.2	pKi	=	6.2	Binding	Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.Binding Assay or Functional Activity Assay: Further, the compounds of the invention may be tested in binding assays and functional activity assays by well known methods for other physiologically important receptors such as, but not limited to, the hERG channel, other serotonin receptors (specifically 5-HT1B, 5-HT1D, receptors, lack of agonist activity at 5-HT2B receptors, 5-HT2C, 5-HT5, 5-HT6, and 5-HT7 receptors), dopaminergic receptors (specifically D1, D2, and D3), GABAA receptors, adrenergic receptors and monoamine transporters.	ChEMBL	433	3	1	6	4.6	Cc1ccc2c(c1)Oc1sc(Cl)cc1C(N1CCN(CC(C)(C)C(=O)O)CC1)=N2	nan
		8447	195728	84	None	-8	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		CHEMBL508112	195728	84	None	-8	13	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	332	3	0	6	5.7	c1ccc2sc(SSc3nc4ccccc4s3)nc2c1	nan
		3191	109635	97	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		CHEMBL305660	109635	97	None	-12	25	Human	6.2	pKi	=	6.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	nan
		145969934	171824	0	None	-54	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	261	7	1	2	4.2	CCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4226336	171824	0	None	-54	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	261	7	1	2	4.2	CCCCCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		14198573	204862	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	1	2	3.6	COc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL574340	204862	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	273	2	1	2	3.6	COc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1016/j.bmc.2009.05.079
		130424	211124	14	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	327	1	1	3	4.4	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2cccc3ccoc23)C1	10.1021/jm00170a025
		CHEMBL71600	211124	14	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	327	1	1	3	4.4	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2cccc3ccoc23)C1	10.1021/jm00170a025
		44415827	87834	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL215414	87834	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	505	4	1	7	4.5	COc1cccc(OC)c1C(=O)NN1c2ccccc2N=C(N2CCN(C)CC2)c2cc(Cl)ccc21	10.1016/j.bmcl.2006.06.034
		11619691	161835	0	None	138	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	467	3	1	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(O)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		CHEMBL401690	161835	0	None	138	2	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	467	3	1	5	3.8	COc1cc2c(cc1OC)-c1c(OC)c(O)c(I)c3c1[C@H](C2)N(C)CC3	10.1021/jm060959i
		5311428	106883	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL1744078	106883	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		CHEMBL287504	106883	9	None	32	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	253	1	1	2	3.0	CN1CCc2ccc(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00079a008
		56589560	77372	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
		CHEMBL1949725	77372	0	None	-1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
		1353	8692	93	None	-38	85	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		3559	8692	93	None	-38	85	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		86	8692	93	None	-38	85	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		CHEMBL54	8692	93	None	-38	85	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		DB00502	8692	93	None	-38	85	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2009.09.041
		6603820	102549	19	None	-4	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.ejmech.2011.11.039
		CHEMBL25856	102549	19	None	-4	12	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	10.1016/j.ejmech.2011.11.039
		440229	94286	53	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		CHEMBL2334891	94286	53	None	1	5	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hrDisplacement of [3H]SCH23390 from human 3HA-tagged dopamine D1 receptor expressed in HEK293 cells after 1 hr	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmcl.2017.01.090
		6917970	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		8370	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		CHEMBL487387	10463	61	None	-1	33	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	10.1016/j.bmc.2012.05.057
		3246443	44460	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL1457510	44460	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		9869262	111638	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		CHEMBL310997	111638	0	None	-1	3	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@H]2CCCN2CCCCCCN2CCC[C@@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		3246443	44460	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
		CHEMBL1457510	44460	2	None	2	6	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hrDisplacement of [3H]SCH23390 from human dopamine D1 receptor after 1 hr	ChEMBL	325	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmcl.2017.01.090
		10709445	108140	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115377	108140	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL296993	108140	0	None	26	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		10107367	109211	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL303993	109211	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		71261649	94287	9	None	15	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		CHEMBL2334892	94287	9	None	15	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	341	3	1	5	3.1	COc1cc2c(cc1O)[C@H]1Cc3ccc(OC)c(OC)c3CN1CC2	10.1016/j.bmc.2012.12.016
		10640108	91186	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2114441	91186	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		CHEMBL2219802	91186	0	None	208	2	Rat	8.2	pKi	=	8.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@@H]1CCc3cc(O)c(O)cc3[C@@H]21	10.1021/jm970038v
		10107367	109211	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
		CHEMBL303993	109211	1	None	-7	4	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00118a012
		14198585	107578	1	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL293158	107578	1	None	1	4	Rat	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		10107367	109211	1	None	7	4	Human	8.2	pKi	=	8.2	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
		CHEMBL303993	109211	1	None	7	4	Human	8.2	pKi	=	8.2	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00129a006
		127031399	145520	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	2	6	2.8	COc1cc2c(cc1O)C1Cc3ccc(OCCCO)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		CHEMBL3780268	145520	0	None	16	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	385	6	2	6	2.8	COc1cc2c(cc1O)C1Cc3ccc(OCCCO)c(OC)c3CN1CC2	10.1016/j.bmc.2016.03.037
		71109797	152674	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		CHEMBL3917753	152674	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		71109797	152674	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		CHEMBL3917753	152674	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1ccc(OC)c2c1C[C@H]1c3cc(O)c(O)cc3CCN1C2	nan
		130442514	173311	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4279267	173311	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	355	3	0	5	5.6	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ccc2nccn12	10.1021/acs.jmedchem.8b01622
		25110709	19378	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL1186967	19378	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
		CHEMBL484538	19378	0	None	17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	373	2	2	3	5.0	Cc1cccc(-c2c(O)c(O)cc3c2CCN(C)CC3c2cccc(C)c2)c1	10.1016/j.bmc.2008.09.049
		86764103	139215	13	None	-	1	Human	8.2	pKi	=	8.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697578	139215	13	None	-	1	Human	8.2	pKi	=	8.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	389	5	1	6	3.1	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44415600	86560	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	461	4	1	6	4.8	COc1ccccc1CNN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL211910	86560	0	None	3	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	461	4	1	6	4.8	COc1ccccc1CNN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		122205437	144089	0	None	-19	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2sccc2CC1	10.1039/C5MD00258C
		CHEMBL3752512	144089	0	None	-19	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor incubated for 90 mins by radioligand binding assay	ChEMBL	257	0	0	2	3.4	CN1CCc2ccccc2Cc2sccc2CC1	10.1039/C5MD00258C
		12313091	93253	6	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1ccc2c(c1O)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL2314732	93253	6	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	325	1	1	5	2.8	COc1ccc2c(c1O)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		11023546	85253	0	None	-5	3	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	85253	0	None	-5	3	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		11023546	85253	0	None	-5	3	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	85253	0	None	-5	3	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		10071501	16651	0	None	10	2	Rat	7.2	pKi	=	7.2	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		CHEMBL114228	16651	0	None	10	2	Rat	7.2	pKi	=	7.2	Binding	Compound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assayCompound was tested for the Binding affinity against Human cloned Dopamine receptor D1 by Radio ligand ([3H]SCH-23390) binding assay	ChEMBL	432	5	1	3	5.8	CN(C)c1ccc(/C=C/CN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		44393415	72004	0	None	-251	5	Pig	6.2	pKi	=	6.2	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	499	8	1	5	3.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1	10.1016/j.bmcl.2004.05.052
		CHEMBL182652	72004	0	None	-251	5	Pig	6.2	pKi	=	6.2	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	499	8	1	5	3.7	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(I)s2)CC1	10.1016/j.bmcl.2004.05.052
		137638973	163653	0	None	-1479	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccc2c(/C=N/O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4071868	163653	0	None	-1479	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	10	2	7	4.3	CCCN(CCCCOc1ccc2c(/C=N/O)cnn2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		56837419	76079	0	None	-2630	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	997	35	2	14	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928128	76079	0	None	-2630	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	997	35	2	14	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		46917563	75110	0	None	-8511	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	561	18	1	7	5.5	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)C3Cc4ccccc4C3)cc2OC)nn1	10.1021/jm2009919
		CHEMBL1916551	75110	0	None	-8511	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	561	18	1	7	5.5	CCCCn1cc(CCCOc2ccc(C(=O)NCCCCN(CCC)C3Cc4ccccc4C3)cc2OC)nn1	10.1021/jm2009919
		2780	117306	36	None	-138	10	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00678-4
		CHEMBL325109	117306	36	None	-138	10	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	10.1016/s0960-894x(03)00678-4
		137634153	163211	0	None	-54	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	236	1	2	5	0.6	Oc1ccc(N2CCNCC2)c2c1OCCO2	10.1016/j.bmc.2017.08.037
		CHEMBL4066916	163211	0	None	-54	4	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	236	1	2	5	0.6	Oc1ccc(N2CCNCC2)c2c1OCCO2	10.1016/j.bmc.2017.08.037
		10775901	42553	1	None	-70	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cc(C)cc(C)c2)C1	10.1021/jm9708700
		CHEMBL144114	42553	1	None	-70	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cc(C)cc(C)c2)C1	10.1021/jm9708700
		10609576	125530	0	None	-42	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cccc(C)c2C)C1	10.1021/jm9708700
		CHEMBL341825	125530	0	None	-42	2	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2cccc(C)c2C)C1	10.1021/jm9708700
		72545008	99898	0	None	-89	5	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	451	15	0	9	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443001	99898	0	None	-89	5	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	451	15	0	9	1.6	COc1ccccc1N1CCN(Cc2cn(CCOCCOCCOCCF)nn2)CC1	10.1016/j.bmcl.2013.09.026
		15654859	209811	0	None	4	2	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3N(C)c3ccccc32)CC1	10.1021/jm00067a009
		CHEMBL63390	209811	0	None	4	2	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	307	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3N(C)c3ccccc32)CC1	10.1021/jm00067a009
		13994412	17936	1	None	-117	3	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL117841	17936	1	None	-117	3	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	265	1	0	2	3.4	COc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		10689791	171660	0	None	12	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	4	2	3	3.3	NCCCC(=O)N1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL422086	171660	0	None	12	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	358	4	2	3	3.3	NCCCC(=O)N1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		490	6979	8	None	-60255	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		9890547	6979	8	None	-60255	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		CHEMBL268758	6979	8	None	-60255	12	Rat	5.2	pKi	=	5.2	Binding	Ancillary Binding affinity to rat Dopamine receptor D1Ancillary Binding affinity to rat Dopamine receptor D1	ChEMBL	462	6	1	7	3.2	COc1ccccc1N1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)c(cs2)c1ccccc1	10.1016/s0960-894x(01)00159-7
		10015045	20424	1	None	-6	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm9015763
		CHEMBL119455	20424	1	None	-6	6	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	251	0	1	2	3.1	CN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm9015763
		9992499	80161	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
		CHEMBL201483	80161	0	None	1	4	Human	7.2	pKi	=	7.2	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	254	0	0	2	2.6	CN1CCc2ccccc2Cc2ccn(C)c2CC1	10.1021/jm050846j
		72699816	121965	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	329	3	1	4	4.1	CCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344457	121965	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	329	3	1	4	4.1	CCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		145966311	170812	0	None	-3388	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cells	ChEMBL	378	5	1	4	2.9	O=C(NCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccccn1	10.1016/j.bmc.2017.09.018
		CHEMBL4208744	170812	0	None	-3388	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH-23390 from human recombinant dopamine D1 receptor expressed in CHO cells	ChEMBL	378	5	1	4	2.9	O=C(NCCN1CCN(c2ccc(Cl)c(Cl)c2)CC1)c1ccccn1	10.1016/j.bmc.2017.09.018
		57402366	76090	0	None	-1230	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1033	32	2	17	5.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928139	76090	0	None	-1230	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1033	32	2	17	5.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		44340333	16434	0	None	-1071	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL112833	16434	0	None	-1071	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	384	5	1	3	3.8	C#Cc1cc(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)c(OC)c2ccccc12	10.1016/s0960-894x(03)00678-4
		44340227	117418	0	None	-2137	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL325772	117418	0	None	-2137	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	486	5	1	3	4.5	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(I)c2ccccc12	10.1016/s0960-894x(03)00678-4
		10265732	101624	0	None	2	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL253738	101624	0	None	2	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		2477	7532	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		36	7532	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		437	7532	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		CHEMBL49	7532	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		DB00490	7532	59	None	-28	29	Bovine	5.2	pKi	=	5.2	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	10.1021/jm950759z
		15508242	172028	0	None	-64	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
		CHEMBL422959	172028	0	None	-64	4	Bovine	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1Displacement of [3H]SCH-23390 from bovine striatal membrane Dopamine receptor D1	ChEMBL	268	4	0	3	3.1	O=Cc1ccn(C2CCN(Cc3ccccc3)CC2)c1	10.1016/s0960-894x(99)00540-5
		838674	114202	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		CHEMBL318111	114202	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		CHEMBL542493	114202	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00163a007
		44316331	212278	0	None	-41	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		CHEMBL80686	212278	0	None	-41	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	468	11	4	6	4.8	Oc1ccc(C[C@@H]2CCCN2CCCCCCN2CCC[C@H]2Cc2ccc(O)c(O)c2)cc1O	10.1016/0960-894X(95)00413-N
		10378389	210024	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		CHEMBL134807	210024	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		CHEMBL64553	210024	1	None	-14454	7	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		838674	114202	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		CHEMBL318111	114202	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		CHEMBL542493	114202	12	None	-2570	2	Rat	6.2	pKi	=	6.2	Binding	Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390Compound was evaluated for its ability to inhibit Dopamine receptor D1 in rat striatum using [3H]SCH-23390	ChEMBL	293	2	2	3	3.4	C=CCN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00105a005
		71817345	98754	0	None	-158	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
		CHEMBL2414992	98754	0	None	-158	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
		44415567	86810	0	None	58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212905	86810	0	None	58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccc(C#N)c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415579	86620	0	None	61	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	542	4	2	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3NC3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212186	86620	0	None	61	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	542	4	2	6	6.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3NC3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		72699817	121966	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		CHEMBL3344458	121966	0	None	-3	4	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	343	4	1	4	4.5	CCCCc1cc2c(s1)C[C@H]1c3cc(O)c(OC)cc3CCN1C2	10.1016/j.bmc.2014.09.024
		46931072	208824	1	None	-8	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		CHEMBL608530	208824	1	None	-8	5	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligandBinding affinity towards human D1 dopamine receptor was determined by using [3H]-SCH- 23390 as radioligand	ChEMBL	386	4	0	4	4.9	CN1CCCC[C@H]1CCN1c2ccccc2Sc2ccc([S+](C)[O-])cc21	10.1016/j.bmcl.2004.06.078
		2389	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		5073	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		96	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		CHEMBL85	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		DB00734	10104	118	None	-489	66	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	10.1021/jm030480f
		122189391	130024	0	None	-72	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	431	7	0	9	2.1	COc1ccccc1N1CCN(CCc2cn(-c3ccn4ncc(C=O)c4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
		CHEMBL3613877	130024	0	None	-72	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assayDisplacement of [3H]SCH23990 from human dopamine D1 receptor expressed in CHO cell membranes by radioligand competition binding assay	ChEMBL	431	7	0	9	2.1	COc1ccccc1N1CCN(CCc2cn(-c3ccn4ncc(C=O)c4c3)nn2)CC1	10.1016/j.bmc.2015.07.050
		44264742	103949	0	None	-13	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	298	3	0	4	2.8	c1ccn2ncc(CN3CCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(98)00692-1
		CHEMBL268190	103949	0	None	-13	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	298	3	0	4	2.8	c1ccn2ncc(CN3CCN(C4CCCCC4)CC3)c2c1	10.1016/s0960-894x(98)00692-1
		2	10035	23	None	-977	28	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
		54562	10035	23	None	-977	28	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
		CHEMBL240773	10035	23	None	-977	28	Human	7.2	pKi	=	7.2	Binding	Binding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cellsBinding affinity (high) towards human dopamine receptor 2 long against radioligand [3H]spiperone, expressed in Chinese hamster ovary cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm0503805
		11023546	85253	0	None	-5	3	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	85253	0	None	-5	3	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		9839050	119156	0	None	-131	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		CHEMBL329566	119156	0	None	-131	9	Human	7.2	pKi	=	7.2	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	293	2	0	2	3.8	CN(C)C[C@H]1C[C@@H]2c3ccccc3Cc3ccccc3[C@H]2O1	10.1021/jm049632c
		117773522	139222	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	6	3.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697585	139222	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	407	4	1	6	3.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		24863698	183477	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	253	0	2	2	2.7	Oc1ccc2c(c1)CCNCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		CHEMBL459871	183477	0	None	-1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human cloned dopamine D1 receptorDisplacement of [3H]SCH23390 from human cloned dopamine D1 receptor	ChEMBL	253	0	2	2	2.7	Oc1ccc2c(c1)CCNCCc1ccccc1C2	10.1016/j.bmcl.2008.04.081
		11023546	85253	0	None	-5	3	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL2111783	85253	0	None	-5	3	Rat	7.2	pKi	=	7.2	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	317	1	0	4	3.1	CN1CCN([C@H]2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		3108374	98752	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
		CHEMBL2414990	98752	24	None	-3	3	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	295	2	0	3	3.5	COc1cc2c3c(c1OC)-c1ccccc1CC3N(C)CC2	10.1016/j.bmcl.2013.06.078
		44400626	77177	0	None	-999	5	Pig	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL194555	77177	0	None	-999	5	Pig	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		44403214	79268	0	None	-446	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)nc2)CC1	10.1016/j.bmcl.2005.07.037
		CHEMBL198993	79268	0	None	-446	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	386	8	1	5	2.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(F)nc2)CC1	10.1016/j.bmcl.2005.07.037
		44448063	162024	0	None	3	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		CHEMBL402736	162024	0	None	3	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	10.1021/jm060959i
		154727713	183143	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4514586	183143	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4595727	183143	1	None	-7	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	426	10	1	6	4.5	COc1ccc(F)cc1C1CC1CNCCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		118717797	121971	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	2	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344463	121971	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	357	2	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC(C)(C)C)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		10758760	29273	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	329	4	1	2	4.8	CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL132545	29273	0	None	3	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	329	4	1	2	4.8	CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		161379	193994	8	None	-79	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
		CHEMBL492418	193994	8	None	-79	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	293	3	0	3	3.8	CN(C)CCc1cc2c(c3c1ccc1ccccc13)OCO2	10.1016/j.bmcl.2013.06.078
		154703438	183160	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		CHEMBL4475699	183160	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		CHEMBL4595859	183160	1	None	-26	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	496	12	0	6	6.1	COc1ccc(Cl)cc1C1CC1CN(CCCSc1nnc(-c2ccccc2)n1C)CC1CC1	10.1021/acs.jmedchem.9b01835
		136043857	86561	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	5.0	Clc1ccc2c(c1)N=C(N1CCN(Cc3cccc4c3OCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
		CHEMBL211915	86561	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	5.0	Clc1ccc2c(c1)N=C(N1CCN(Cc3cccc4c3OCO4)CC1)c1ccccc1N2	10.1016/j.bmcl.2006.06.034
		44281881	106625	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL1743774	106625	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		CHEMBL285717	106625	0	None	-	1	Rat	7.2	pKi	=	7.2	Binding	Binding affinity towards Dopamine receptor D1Binding affinity towards Dopamine receptor D1	ChEMBL	281	1	2	3	3.4	Oc1cc2c(cc1O)[C@@H]1CCCN1C[C@H]2c1ccccc1	10.1021/jm00391a028
		1242	10385	27	None	1	17	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		935	10385	27	None	1	17	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		CHEMBL286080	10385	27	None	1	17	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		44415743	86883	0	None	30	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213201	86883	0	None	30	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc(C#N)cc3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		6852376	98374	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
		CHEMBL1467585	98374	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
		CHEMBL24077	98374	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
		CHEMBL503958	98374	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00114a002
		6852376	98374	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
		CHEMBL1467585	98374	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
		CHEMBL24077	98374	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
		CHEMBL503958	98374	13	None	-4	5	Rat	7.2	pKi	=	7.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/jm00112a034
		1242	10385	27	None	1	17	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		935	10385	27	None	1	17	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		CHEMBL286080	10385	27	None	1	17	Rat	7.2	pKi	=	7.2	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	10.1021/jm00173a005
		70684206	82840	0	None	11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		CHEMBL2057442	82840	0	None	11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	385	5	1	6	2.9	COc1cc2c(cc1OC)[C@@H]1Cc3c(CO)c(OC)cc(OC)c3CN1CC2	10.1016/j.bmc.2012.05.057
		70692653	82841	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL2057443	82841	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		70692652	82839	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
		CHEMBL2057441	82839	0	None	8	2	Human	7.2	pKi	=	7.2	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)c(OC)cc3[C@@H]1C2	nan
		54580905	68377	0	None	-2570	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771107	68377	0	None	-2570	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	469	8	0	4	5.0	COc1ccccc1N1CCN(CCCCN2CCc3cc(-c4ccccc4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		56594533	77373	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
		CHEMBL1949726	77373	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in human HEK293 cells	ChEMBL	304	0	1	1	4.2	C[C@@H]1Cc2c([nH]c3ccccc23)Cc2ccccc2CCN1C	10.1021/jm200676f
		56837634	76081	0	None	-1479	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1041	38	2	15	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928130	76081	0	None	-1479	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1041	38	2	15	6.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		9796958	153356	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115374	153356	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL39230	153356	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL544814	153356	0	None	25	4	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	315	2	3	4	3.7	CCCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		11633170	85187	0	None	-2818	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	421	5	0	7	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1	10.1021/jm060166w
		CHEMBL211118	85187	0	None	-2818	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	421	5	0	7	2.8	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1	10.1021/jm060166w
		11583188	146060	0	None	-19498	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	448	4	0	5	3.3	COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1	10.1021/jm060166w
		CHEMBL379125	146060	0	None	-19498	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	448	4	0	5	3.3	COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1	10.1021/jm060166w
		10355510	162441	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL404865	162441	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		71461481	90845	0	None	-676	5	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	356	4	0	3	4.1	C#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
		CHEMBL2207632	90845	0	None	-676	5	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	356	4	0	3	4.1	C#Cc1cc(CN2CCN(c3ccccc3OC)CC2)c2cccccc1-2	10.1016/j.bmcl.2012.09.064
		71450707	90853	0	None	-1698	7	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	444	6	0	5	3.9	COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207640	90853	0	None	-1698	7	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	444	6	0	5	3.9	COc1ccccc1N1CCN(Cc2cc(CN3CCN(C)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		25131135	194327	0	None	-95	2	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	448	6	3	5	4.7	Nc1nc2c(s1)C[C@@H](NCC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
		CHEMBL494510	194327	0	None	-95	2	Rat	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatumDisplacement of [3H]SCH23390 from D1-like receptor in Sprague-Dawley rat striatum	ChEMBL	448	6	3	5	4.7	Nc1nc2c(s1)C[C@@H](NCC[C@H]1CC[C@H](NC(=O)c3ccc4ccccc4c3)CC1)CC2	10.1021/jm800471h
		90644058	118806	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		CHEMBL3289642	118806	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		90644058	118806	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		CHEMBL3289642	118806	0	None	-104	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	372	4	0	3	4.0	O=C1c2ccc(F)cc2CC1CCN1CCN(c2ccc(Cl)cc2)CC1	10.1016/j.bmc.2014.04.026
		130907	201462	5	None	-3311	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm701045j
		CHEMBL53294	201462	5	None	-3311	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm701045j
		64143	205643	62	None	-1	8	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		CHEMBL584	205643	62	None	-1	8	Human	5.2	pKi	=	5.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	nan
		154725277	183211	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4472900	183211	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4596220	183211	1	None	-25	6	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1ccc(Cl)cc1	10.1021/acs.jmedchem.9b01835
		10015860	106053	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		CHEMBL281932	106053	0	None	38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	268	0	3	4	2.0	Oc1cc2c(cc1O)[C@H]1c3cccnc3CN[C@@H]1CC2	10.1016/s0960-894x(99)00214-0
		44415598	84793	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccc(S(=O)(=O)N2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
		CHEMBL209805	84793	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccc(S(=O)(=O)N2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.034
		44415612	145733	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	6	6.0	CCOc1ccc2ccccc2c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		CHEMBL378512	145733	0	None	4	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	539	4	1	6	6.0	CCOc1ccc2ccccc2c1C(=O)NN1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.022
		134149077	155102	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	4	2	5	3.9	CCC(C)Oc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3936976	155102	0	None	1	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	369	4	2	5	3.9	CCC(C)Oc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		681	8247	72	None	-23	38	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		940	8247	72	None	-23	38	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		947	8247	72	None	-23	38	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		CHEMBL59	8247	72	None	-23	38	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		DB00988	8247	72	None	-23	38	Bovine	6.2	pKi	=	6.2	Binding	Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.Binding Affinity was tested on low Affinity Site of Bovine Dopamine D1 Receptor. Tested for ability to displace the radioligand [3H]-SCH- 23390 at the binding site.	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		228	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		33	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		6005	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		CHEMBL53	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		DB00714	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Binding affinity to dopamine D1 receptor low binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor low binding site by radioligand displacement assay	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/ml1001689
		117774495	139202	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	396	4	1	6	2.7	Cc1cc(Oc2ncccc2N2CC(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697565	139202	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	396	4	1	6	2.7	Cc1cc(Oc2ncccc2N2CC(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		40152769	208587	2	None	-107	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL606939	208587	2	None	-107	2	Human	5.2	pKi	=	5.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)[C@@H]1CCc2c(O)cccc2C1	10.1021/jm00115a012
		45481888	205793	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		CHEMBL585740	205793	0	None	-5	3	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	610	11	2	9	4.8	COc1ccccc1N1CCN(CCCn2cc(CCCN3CCc4cc(O)c(O)cc4C(c4cccc(C)c4)C3)nn2)CC1	10.1016/j.bmc.2009.06.019
		21171	193755	33	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		CHEMBL490533	193755	33	None	1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	339	2	0	5	3.1	COc1ccc2c(c1OC)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.12.016
		135515431	11019	34	None	-10	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	1	2	6	2.6	CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1	10.1016/S0960-894X(96)00567-7
		CHEMBL100454	11019	34	None	-10	3	Human	7.2	pKi	=	7.2	Binding	In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1In vitro binding affinity of compound against dopamine neuronal Dopamine receptor D1	ChEMBL	328	1	2	6	2.6	CN1CCN(C2=Nc3ccccc3Nc3sc(CO)cc32)CC1	10.1016/S0960-894X(96)00567-7
		72699818	121973	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	341	3	1	4	4.1	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344466	121973	0	None	-5	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	341	3	1	4	4.1	COc1cc2c(cc1O)[C@@H]1Cc3sc(CC4CC4)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		11504230	84992	0	None	-870	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		CHEMBL210567	84992	0	None	-870	7	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		228	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		33	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		6005	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		CHEMBL53	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		DB00714	7233	28	None	-35	23	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2012.07.025
		44448061	101622	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL253736	101622	0	None	1	2	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	10.1021/jm060959i
		45270813	203468	0	None	-776	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)nc(C)n34)CC2)cc1	10.1016/j.bmc.2009.05.015
		CHEMBL564709	203468	0	None	-776	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccc(N2CCN(Cc3c(C)nc4cc(C)nc(C)n34)CC2)cc1	10.1016/j.bmc.2009.05.015
		71457956	85199	0	None	-87	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL2111527	85199	0	None	-87	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		76325152	113148	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		CHEMBL3115579	113148	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		CHEMBL3139262	113148	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		10037962	213486	0	None	-51	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1ABinding affinity against dopamine receptor D1A	ChEMBL	254	0	1	2	3.4	c1cc2c3c(c1)c1c(n3CCNC2)CCCCCC1	10.1016/j.bmcl.2004.02.100
		CHEMBL89738	213486	0	None	-51	3	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1ABinding affinity against dopamine receptor D1A	ChEMBL	254	0	1	2	3.4	c1cc2c3c(c1)c1c(n3CCNC2)CCCCCC1	10.1016/j.bmcl.2004.02.100
		118711254	120729	0	None	-147	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	358	4	2	3	4.6	CN1CCc2cc(NCc3ccccc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325904	120729	0	None	-147	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	358	4	2	3	4.6	CN1CCc2cc(NCc3ccccc3)c(O)cc2C(c2ccccc2)C1	10.1016/j.ejmech.2014.07.059
		42626315	63024	0	None	-1445	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	439	8	2	6	3.2	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		CHEMBL1627320	63024	0	None	-1445	2	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	439	8	2	6	3.2	COc1ccccc1N1CCN(CC(O)CCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		10363751	169859	0	None	-1584	3	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	402	6	0	4	3.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(F)cc2)C1	10.1016/s0960-894x(99)00201-2
		CHEMBL417661	169859	0	None	-1584	3	Rat	5.2	pKi	=	5.2	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	402	6	0	4	3.2	O=C1c2ccccc2S(=O)(=O)N1CCCCN1CCC(c2ccc(F)cc2)C1	10.1016/s0960-894x(99)00201-2
		45269974	20394	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1194307	20394	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL550792	20394	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	371	3	2	3	5.3	CCCN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		91899756	136217	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cc(=O)[nH]nc1C	nan
		CHEMBL3671295	136217	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	332	3	2	4	3.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cc(=O)[nH]nc1C	nan
		9888555	172383	16	None	-3235	8	Human	6.2	pKi	=	6.2	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
		CHEMBL424294	172383	16	None	-3235	8	Human	6.2	pKi	=	6.2	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm025558r
		25071691	118564	0	None	-2818	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		CHEMBL3287403	118564	0	None	-2818	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	461	8	1	7	4.4	O/N=C/c1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		6469918	86666	13	None	-954	6	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL212370	86666	13	None	-954	6	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
		71450812	85197	0	None	-338	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL2111525	85197	0	None	-338	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	455	8	1	5	4.7	COc1ccc(Br)cc1-c1nc(CNCC2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		3036864	209533	19	None	-2	27	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1256645	209533	19	None	-2	27	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL1814790	209533	19	None	-2	27	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL62	209533	19	None	-2	27	Rat	6.2	pKi	=	6.2	Binding	Binding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranesBinding affinity towards dopamine (D1) receptor using [3H]spiperone was determined in rat striatal membranes	ChEMBL	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	10.1021/jm00051a008
		10360174	175027	1	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	344	0	0	5	3.5	CN1CCN(C2=Nc3cccnc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		CHEMBL433744	175027	1	None	-2	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	344	0	0	5	3.5	CN1CCN(C2=Nc3cccnc3Sc3ccc(Cl)cc32)CC1	10.1021/jm00030a011
		10660476	54147	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
		CHEMBL154468	54147	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm991034o
		15654856	209803	0	None	2	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	311	0	1	5	2.6	CN1CCN(C2=Nc3cccnc3Nc3ccc(F)cc32)CC1	10.1021/jm00067a009
		CHEMBL63347	209803	0	None	2	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	311	0	1	5	2.6	CN1CCN(C2=Nc3cccnc3Nc3ccc(F)cc32)CC1	10.1021/jm00067a009
		42625207	63008	0	None	-257	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	421	7	1	5	4.0	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		CHEMBL1627304	63008	0	None	-257	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	421	7	1	5	4.0	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		44323890	213696	0	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	316	1	0	2	4.2	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL90977	213696	0	None	1	4	Rat	7.2	pKi	=	7.2	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	316	1	0	2	4.2	C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		3039881	181036	10	None	4	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
		CHEMBL45491	181036	10	None	4	3	Human	7.2	pKi	=	7.2	Binding	Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1Binding affinity determined in radioreceptor binding assay by using [3H]SCH-23390 radioligand against dopamine receptor D1	ChEMBL	337	1	0	1	5.0	CN(C)C1C=CC2(CC1)c1ccccc1CCc1ccc(Cl)cc12	10.1021/jm00109a026
		44415638	86659	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212334	86659	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C#N)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415490	146016	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C(F)(F)F)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL378886	146016	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	513	2	1	5	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc(C(F)(F)F)cc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		134150645	158424	0	None	10	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	475	7	2	5	5.5	CCCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3963862	158424	0	None	10	3	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	475	7	2	5	5.5	CCCCCCOc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		44300069	202896	0	None	35	2	Rat	7.2	pKi	=	7.2	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL56100	202896	0	None	35	2	Rat	7.2	pKi	=	7.2	Binding	In vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenatesIn vitro affinity of compound towards dopamine (D1) receptor was determined by measuring their ability to displace [3H]SCH-23,390 from rat striatal homogenates	ChEMBL	295	0	2	3	3.0	CN1CCc2cc(O)c(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		41532205	85052	1	None	-954	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
		CHEMBL210717	85052	1	None	-954	4	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	336	4	0	4	3.3	Fc1ccccc1N1CCN(Cc2cnn(-c3ccccc3)c2)CC1	10.1016/j.bmcl.2006.02.075
		11504230	84992	0	None	-1023	7	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm100899z
		CHEMBL210567	84992	0	None	-1023	7	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	497	8	1	4	4.9	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm100899z
		145990141	173558	0	None	-323	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	388	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Cl)cc1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4283982	173558	0	None	-323	4	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	388	7	2	4	3.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(Cl)cc1)CC2	10.1021/acsmedchemlett.8b00229
		44454709	104294	0	None	-5248	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	404	9	0	6	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
		CHEMBL270406	104294	0	None	-5248	5	Pig	5.2	pKi	=	5.2	Binding	Binding affinity to pig cortical membrane dopamine D1 receptorBinding affinity to pig cortical membrane dopamine D1 receptor	ChEMBL	404	9	0	6	3.4	COc1cc(CN2CCN(c3ccccc3OC)CC2)c(OCCF)cc1OC	10.1016/j.bmcl.2007.12.026
		12888943	16341	0	None	-812	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL112395	16341	0	None	-812	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	6	2	4	3.8	CNc1cc(OC)c(C(=O)NC2CCN(Cc3ccccc3)CC2)cc1Cl	10.1016/s0960-894x(03)00678-4
		10660476	54147	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
		CHEMBL154468	54147	0	None	-	1	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	10.1021/jm060959i
		25139332	191098	0	None	-7	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	352	11	1	2	5.0	CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
		CHEMBL484204	191098	0	None	-7	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	352	11	1	2	5.0	CCCN(CCC)CCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
		16121920	202654	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	380	5	1	6	2.7	COc1ccccc1N1CCN(Cc2c(C)[nH]c3nc(N(C)C)ncc23)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL558838	202654	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	380	5	1	6	2.7	COc1ccccc1N1CCN(Cc2c(C)[nH]c3nc(N(C)C)ncc23)CC1	10.1016/j.bmc.2009.05.015
		45267435	202770	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1nccc2c(CN3CCN(c4ccccc4)CC3)c[nH]c12	10.1016/j.bmc.2009.05.015
		CHEMBL559868	202770	0	None	-1047	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1nccc2c(CN3CCN(c4ccccc4)CC3)c[nH]c12	10.1016/j.bmc.2009.05.015
		52937776	67944	0	None	-9549	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2nccc2C1	10.1021/jm101639t
		CHEMBL1765629	67944	0	None	-9549	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	430	10	1	4	4.8	CCCN(CCCCNC(=O)c1ccc(-c2ccccc2)cc1)C1CCn2nccc2C1	10.1021/jm101639t
		127046948	146848	0	None	-295	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800468	146848	0	None	-295	6	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	488	12	4	6	4.1	COc1cc(CCNC[C@@H](O)c2ccc(O)c3[nH]c(=O)ccc23)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		118709168	120192	0	None	-33	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1000	29	0	8	14.4	O=C(CCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318840	120192	0	None	-33	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1000	29	0	8	14.4	O=C(CCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		12050200	108867	0	None	-128	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	6	1	4	4.6	c1ccc(CN2CCC(NCc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL302186	108867	0	None	-128	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	6	1	4	4.6	c1ccc(CN2CCC(NCc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		11708363	78677	1	None	-23	4	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@@H]1CCn2nccc2C1	10.1021/jm101639t
		CHEMBL197159	78677	1	None	-23	4	Pig	4.2	pKi	=	4.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 minsDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine cerebral cortex after 60 mins	ChEMBL	221	5	0	3	2.3	CCCN(CCC)[C@@H]1CCn2nccc2C1	10.1021/jm101639t
		44329057	214774	0	None	-93	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL97283	214774	0	None	-93	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
		86767109	136224	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	6	3.5	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
		CHEMBL3671301	136224	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	346	3	1	6	3.5	Cc1ncnc(C#N)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
		52940985	24358	0	None	-69	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
		CHEMBL1258155	24358	0	None	-69	5	Pig	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	369	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3ccc(Cl)cc3)CC2)c1	10.1021/jm100899z
		10666053	107162	0	None	-1	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL289927	107162	0	None	-1	2	Rat	6.2	pKi	=	6.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	357	5	3	4	4.8	CCCCCCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		156013324	184272	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	310	2	1	4	3.0	COc1cc2c3c(c1OC)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4639398	184272	0	None	-4	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	310	2	1	4	3.0	COc1cc2c3c(c1OC)-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		76325152	113148	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		CHEMBL3115579	113148	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		CHEMBL3139262	113148	0	None	-645	5	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	359	9	2	4	4.0	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(OCCCCF)cc1)CC2	10.1021/jm401384w
		90140337	136192	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	4	2	6	3.1	COc1cnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c2c[nH]nc12	nan
		CHEMBL3671271	136192	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	363	4	2	6	3.1	COc1cnc(Oc2ccc(-c3c(C)n[nH]c(=O)c3C)cc2)c2c[nH]nc12	nan
		10333842	105207	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		CHEMBL27559	105207	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatumDisplacement of [3H]SCH-23390 from dopamine D1 receptor in rat striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm701045j
		10333842	105207	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.06.016
		CHEMBL27559	105207	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat corpus striatum	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.06.016
		10333842	105207	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.11.025
		CHEMBL27559	105207	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrainDisplacement of [3H]SCH23390 from dopamine D1 receptor in rat forebrain	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1016/j.bmcl.2008.11.025
		681	8247	72	None	-23	38	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		940	8247	72	None	-23	38	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		947	8247	72	None	-23	38	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		CHEMBL59	8247	72	None	-23	38	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		DB00988	8247	72	None	-23	38	Bovine	8.2	pKi	=	8.2	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1021/jm991098z
		14371639	109900	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00170a025
		CHEMBL307790	109900	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1Binding affinity to displace [3H]- SCH 23390 against Dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00170a025
		46231646	207244	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL598515	207244	0	None	1	3	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	328	0	2	3	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccc(N)cc3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		14371639	109900	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00081a010
		CHEMBL307790	109900	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1Compound was tested for the displacement of [3H]-SCH- 23390 from dopamine receptor D1	ChEMBL	299	0	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3C[C@@H]21	10.1021/jm00081a010
		44415826	87166	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL214503	87166	0	None	32	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	571	2	1	5	5.1	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccccc3I)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415705	145444	0	None	12	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	2	2	6	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL377756	145444	0	None	12	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	2	2	6	5.1	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3c(N)cccc3C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		1218	10388	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
		938	10388	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
		CHEMBL353335	10388	30	None	-11	8	Human	8.2	pKi	=	8.2	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	10.1021/jm00116a004
		11306892	208085	0	None	79	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)Nc4c(Cl)cccc4Cl)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		CHEMBL604129	208085	0	None	79	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	515	2	3	3	6.9	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3cccc(NC(=O)Nc4c(Cl)cccc4Cl)c3CC[C@@H]21	10.1016/j.bmcl.2009.12.100
		15069446	205490	0	None	213	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	293	0	1	2	3.6	Cc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		CHEMBL58205	205490	0	None	213	2	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	293	0	1	2	3.6	Cc1cc2c(cc1O)[C@H]1c3ccccc3CC[C@@H]1N(C)CC2	10.1021/jm00128a038
		44415594	87034	0	None	177	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL213882	87034	0	None	177	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	495	2	1	5	5.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccc4ccccc4c3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		135398737	7745	93	None	-44	90	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		38	7745	93	None	-44	90	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		722	7745	93	None	-44	90	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		CHEMBL42	7745	93	None	-44	90	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		DB00363	7745	93	None	-44	90	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1007/s00044-012-0055-5
		71109804	94281	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	10.1016/j.bmc.2012.12.016
		CHEMBL2334882	94281	0	None	12	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin) expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	323	1	1	4	3.0	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCC4	10.1016/j.bmc.2012.12.016
		71109805	94280	0	None	27	3	Human	8.1	pKi	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
		CHEMBL2334881	94280	0	None	27	3	Human	8.1	pKi	=	8.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	1	1	5	2.8	COc1c(O)ccc2c1CN1CCc3cc4c(cc3[C@@H]1C2)OCCO4	nan
		15937727	123356	0	None	158	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	307	1	1	2	4.6	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCCC2)C1	10.1016/S0960-894X(00)80155-9
		CHEMBL336532	123356	0	None	158	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	307	1	1	2	4.6	CN1CCc2cc(Cl)c(O)cc2C(C2CCCCCC2)C1	10.1016/S0960-894X(00)80155-9
		11536995	146333	1	None	3	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		CHEMBL379662	146333	1	None	3	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1cccc2c1Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		86764210	139216	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	1	4	4.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697579	139216	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	347	4	1	4	4.4	Cc1cc(Oc2ncccc2C2CC2)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		44415552	87015	0	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
		CHEMBL213795	87015	0	None	194	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	459	2	1	5	4.8	Cc1ccc(C(=O)NN2c3ccc(Cl)cc3N=C(N3CCN(C)CC3)c3ccccc32)cc1	10.1016/j.bmcl.2006.06.022
		134157446	160565	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	371	5	2	6	2.8	COCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3982215	160565	0	None	2	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	371	5	2	6	2.8	COCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		9901453	135266	0	None	1	2	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	315	1	0	4	3.3	CN1CCN(C2=Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm0309811
		CHEMBL366679	135266	0	None	1	2	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	315	1	0	4	3.3	CN1CCN(C2=Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm0309811
		44415595	86668	0	None	27	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	3	1	6	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212383	86668	0	None	27	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	528	3	1	6	5.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3N3CCCCC3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		127031423	145540	0	None	6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	369	5	1	5	3.9	CCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		CHEMBL3780506	145540	0	None	6	3	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	369	5	1	5	3.9	CCCOc1ccc2c(c1OC)CN1CCc3cc(OC)c(O)cc3C1C2	10.1016/j.bmc.2016.03.037
		162672733	189798	0	None	102	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	317	1	1	3	4.8	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
		CHEMBL4793813	189798	0	None	102	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	317	1	1	3	4.8	Cc1ccc2c(c1)C(C1=C[C@H](C)N(C)CC1)=Nc1ccccc1N2	10.1016/j.bmcl.2020.127563
		44316024	212232	0	None	-2	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	249	5	2	3	2.9	CCCCN1CCCC1Cc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		CHEMBL80369	212232	0	None	-2	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390	ChEMBL	249	5	2	3	2.9	CCCCN1CCCC1Cc1ccc(O)c(O)c1	10.1016/0960-894X(95)00413-N
		70690498	82842	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		CHEMBL2057445	82842	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	355	4	0	5	3.4	COc1cc2c(c(OC)c1)CN1CCc3cc(OC)cc(OC)c3[C@@H]1C2	10.1016/j.bmc.2012.05.057
		74223774	136203	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	5	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc2nccn12	nan
		CHEMBL3671282	136203	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	355	3	1	5	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)ncc2nccn12	nan
		17756213	156483	1	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm070388+
		CHEMBL394779	156483	1	None	-1	5	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	281	0	1	2	3.4	CN1CCCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm070388+
		135398745	9688	112	None	-26	65	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
		47	9688	112	None	-26	65	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
		CHEMBL715	9688	112	None	-26	65	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
		DB00334	9688	112	None	-26	65	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1039/C5MD00258C
		10540201	107005	0	None	4	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL288536	107005	0	None	4	2	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3sccc3CN[C@H]1CC2	10.1021/jm970038v
		1353	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		3559	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		86	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		CHEMBL54	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		DB00502	8692	93	None	-74	85	Rat	7.2	pKi	=	7.2	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm991034o
		10333842	105207	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		CHEMBL27559	105207	1	None	-50	8	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	2	1	2	3.9	CCCN1CCc2cccc3c2[C@H]1Cc1cccc(O)c1-3	10.1021/jm060959i
		13678336	208761	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	289	1	3	3	3.1	Oc1c(O)c(-c2ccccc2)c2c(c1Cl)CCNCC2	10.1021/jm00160a018
		CHEMBL60808	208761	0	None	-	1	Rat	6.2	pKi	=	6.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	ChEMBL	289	1	3	3	3.1	Oc1c(O)c(-c2ccccc2)c2c(c1Cl)CCNCC2	10.1021/jm00160a018
		10610641	105695	0	None	-47	5	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL27940	105695	0	None	-47	5	Rat	6.2	pKi	=	6.2	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	249	0	0	1	3.7	Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		11638780	83870	0	None	-1737	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	345	3	0	5	2.8	Fc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL207488	83870	0	None	-1737	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	345	3	0	5	2.8	Fc1ccc(N2CCN(Cc3cn4nc(Cl)ccc4n3)CC2)cc1	10.1021/jm060166w
		70686495	83344	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccc(Br)cc3)[C@H]21	10.1016/j.ejmech.2012.07.025
		CHEMBL2062856	83344	0	None	-1	3	Human	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H](CO)[C@H]2CN(Cc3ccccc3)[C@H](c3ccc(Br)cc3)[C@H]21	10.1016/j.ejmech.2012.07.025
		44372198	55914	0	None	-239	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	420	4	0	4	5.1	Fc1ccc(-c2cccc3c(CN4CCN(c5ccc(Cl)cc5)CC4)cnn23)cc1	10.1016/s0960-894x(01)00814-9
		CHEMBL156198	55914	0	None	-239	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	420	4	0	4	5.1	Fc1ccc(-c2cccc3c(CN4CCN(c5ccc(Cl)cc5)CC4)cnn23)cc1	10.1016/s0960-894x(01)00814-9
		44270444	56098	0	None	-138	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
		CHEMBL156369	56098	0	None	-138	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	340	3	0	4	3.6	Cc1cccn2ncc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1016/s0960-894x(01)00814-9
		11078813	118795	0	None	-19	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	356	4	1	5	2.8	OCc1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
		CHEMBL328925	118795	0	None	-19	4	Bovine	4.2	pKi	=	4.2	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	356	4	1	5	2.8	OCc1cnn2cccc(CN3CCN(c4ccc(Cl)cc4)CC3)c12	10.1021/jm015522j
		12928483	20119	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
		CHEMBL1192258	20119	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
		CHEMBL543472	20119	0	None	6	2	Human	6.2	pKi	=	6.2	Binding	Inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatumInhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 from canine striatum	ChEMBL	239	1	2	2	2.7	Oc1ccc2c(c1)C(c1ccccc1)CNCC2	10.1021/jm00079a008
		44320116	170887	0	None	7	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL420972	170887	0	None	7	2	Rat	6.2	pKi	=	6.2	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	279	6	3	4	3.0	CCCCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		10810641	16164	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL111509	16164	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
		CHEMBL544089	16164	0	None	-21	2	Rat	5.2	pKi	=	5.2	Binding	In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.In vitro ability to displace [3H]SCH-23390 binding from Dopamine receptor D1 in rat striatal membrane.	ChEMBL	394	7	0	4	3.8	O=C(CCCN1CCN(CC2CC(=O)c3ccccc32)CC1)c1ccc(F)cc1	10.1021/jm981094e
		156011233	184078	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	334	3	1	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4636589	184078	0	None	-1	4	Human	6.2	pKi	=	6.2	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	334	3	1	4	3.0	C#CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		44415599	145229	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccccc1S(=O)(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		CHEMBL377452	145229	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	480	2	0	5	4.8	Cc1ccccc1S(=O)(=O)N1c2ccc(Cl)cc2N=C(N2CCN(C)CC2)c2ccccc21	10.1016/j.bmcl.2006.06.034
		9857902	67578	0	None	-26	4	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	311	1	0	4	3.5	Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		CHEMBL176169	67578	0	None	-26	4	Rat	7.2	pKi	=	7.2	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	311	1	0	4	3.5	Cc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		15115512	16169	7	None	-104	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	324	6	2	3	3.8	CCCN(CCc1ccc(N)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL111532	16169	7	None	-104	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	324	6	2	3	3.8	CCCN(CCc1ccc(N)cc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		25093832	162659	0	None	-2290	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4060461	162659	0	None	-2290	5	Human	6.2	pKi	=	6.2	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		11574902	85225	0	None	-28183	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	400	4	0	5	3.4	COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1	10.1021/jm060166w
		CHEMBL211164	85225	0	None	-28183	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	400	4	0	5	3.4	COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1	10.1021/jm060166w
		44339953	116477	0	None	-707	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
		CHEMBL322802	116477	0	None	-707	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	387	5	2	4	3.6	COc1cc(N)c(Cl)cc1C(=O)N[C@H]1CCN(Cc2ccccc2)C[C@@H]1C	10.1016/s0960-894x(03)00678-4
		17469721	84800	5	None	-22	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	320	4	0	6	2.0	c1ccc(-n2cc(CN3CCN(c4ncccn4)CC3)cn2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL209832	84800	5	None	-22	4	Pig	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	320	4	0	6	2.0	c1ccc(-n2cc(CN3CCN(c4ncccn4)CC3)cn2)cc1	10.1016/j.bmcl.2006.02.075
		45271691	202332	0	None	-107	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	369	3	0	5	3.6	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		CHEMBL554692	202332	0	None	-107	4	Bovine	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	369	3	0	5	3.6	Cc1cc2nc(C)c(CN3CCN(c4ccc(Cl)cc4)CC3)n2c(C)n1	10.1016/j.bmc.2009.05.015
		44372338	60620	0	None	-2511	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	398	4	0	4	3.9	C[Si](C)(C)c1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL160454	60620	0	None	-2511	4	Bovine	5.2	pKi	=	5.2	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	398	4	0	4	3.9	C[Si](C)(C)c1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		44329099	214860	0	None	-40	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL97750	214860	0	None	-40	3	Bovine	4.2	pKi	=	4.2	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2ccc(C)c2C1	10.1016/s0960-894x(01)00564-9
		25186023	194523	0	None	-50118	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	10.1021/jm800689g
		CHEMBL495572	194523	0	None	-50118	4	Rat	5.2	pKi	=	5.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	ChEMBL	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	10.1021/jm800689g
		10527469	163044	3	None	-1548	16	Mouse	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
		CHEMBL40650	163044	3	None	-1548	16	Mouse	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 using [3H]SCH-23390 as radioligand	ChEMBL	448	4	1	7	3.0	COc1cccc2c1CC[C@H]1CN(CCn3c(=O)[nH]c4c(sc5cccnc54)c3=O)C[C@@H]21	10.1021/jm970364a
		10421583	105959	1	None	-9	5	Rat	6.1	pKi	=	6.1	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm960189i
		CHEMBL281357	105959	1	None	-9	5	Rat	6.1	pKi	=	6.1	Binding	In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1In vitro displacement of [3H]SCH-23390 binding to rat striatal Dopamine receptor D1	ChEMBL	235	0	0	1	3.4	CN1CCc2cccc3c2[C@H]1Cc1ccccc1-3	10.1021/jm960189i
		CHEMBL4520788	220754	10	None	-33	25	Human	6.1	pKi	=	6.1	Binding	Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a DRD1Selectivity interaction (GPCR panel (PDSP screen)) EUB0000743a DRD1	ChEMBL		None	None	None		CNCc1ccccc1-c1csc([C@H](C)Nc2nc(C)nc3cc(OC)c(OC)cc23)c1	10.6019/CHEMBL5212743
		72699904	121977	0	None	-60	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	377	5	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344470	121977	0	None	-60	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	377	5	1	4	4.7	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		44385715	67849	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	280	1	0	2	3.8	CN1CCc2cccc3c2c(cn3-c2ccc(F)cc2)C1	10.1016/s0960-894x(98)00138-3
		CHEMBL176476	67849	0	None	1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	280	1	0	2	3.8	CN1CCc2cccc3c2c(cn3-c2ccc(F)cc2)C1	10.1016/s0960-894x(98)00138-3
		156011458	184083	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	2	2	3	3.4	COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4636741	184083	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	347	2	2	3	3.4	COc1cc2c(cc1O)C(c1ccccc1Br)CNCC2	10.1016/j.bmcl.2020.127305
		228	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		33	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		6005	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		CHEMBL53	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		DB00714	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.bmc.2009.04.047
		228	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		33	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		6005	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		CHEMBL53	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		DB00714	7233	28	None	-35	23	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counterDisplacement of [3H]SCH23390 from human D1 dopamine receptor expressed in Ltk fibroblast cells after 60 mins by liquid scintillation counter	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1016/j.ejmech.2011.04.028
		13869641	120180	0	None	-29	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	431	8	0	4	5.4	CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318824	120180	0	None	-29	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	431	8	0	4	5.4	CCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		9819674	19706	0	None	-10	4	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL118919	19706	0	None	-10	4	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		74223827	136220	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	335	3	1	5	4.0	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
		CHEMBL3671298	136220	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	335	3	1	5	4.0	Cc1ncnc(C)c1-c1ccc(Oc2nccc3n[nH]cc23)cc1F	nan
		9819674	19706	0	None	-10	4	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		CHEMBL118919	19706	0	None	-10	4	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	347	3	1	5	2.4	OCCN1CCN(C2Cn3cccc3Sc3ccc(F)cc32)CC1	10.1021/jm010982y
		11208237	107751	0	None	109	2	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	279	0	1	2	3.3	CN1CCc2ccc(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		CHEMBL294221	107751	0	None	109	2	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	279	0	1	2	3.3	CN1CCc2ccc(O)cc2[C@H]2c3ccccc3CC[C@@H]21	10.1021/jm00128a038
		10849018	20709	0	None	-120	3	Rat	6.1	pKi	=	6.1	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	261	1	0	1	4.1	C=Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		CHEMBL119656	20709	0	None	-120	3	Rat	6.1	pKi	=	6.1	Binding	Affinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	261	1	0	1	4.1	C=Cc1cccc2c1-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960189i
		44400585	75430	0	None	-1949	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL191962	75430	0	None	-1949	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		10425969	107785	3	None	-1862	4	Bovine	5.1	pKi	=	5.1	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
		CHEMBL294459	107785	3	None	-1862	4	Bovine	5.1	pKi	=	5.1	Binding	Ability to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determinedAbility to displace D1 selective radioligand [3H]-SCH- 23390 in bovine striatal membrane preparations was determined	ChEMBL	317	4	1	4	2.8	N#CC(C#N)=Cc1cc(CN2CCN(c3ccccc3)CC2)c[nH]1	10.1016/s0960-894x(99)00302-9
		14809026	212566	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL83080	212566	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		14809026	212566	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
		CHEMBL83080	212566	3	None	-4	3	Rat	5.1	pKi	=	5.1	Binding	Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro)	ChEMBL	271	2	3	4	2.4	NC[C@H]1O[C@@H](c2ccccc2)Cc2c1ccc(O)c2O	10.1021/jm00173a005
		10551026	108394	0	None	-724	5	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL298875	108394	0	None	-724	5	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		44448067	162308	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
		CHEMBL404240	162308	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
		2	10035	23	None	-16595	28	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
		54562	10035	23	None	-16595	28	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
		CHEMBL240773	10035	23	None	-16595	28	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm901120h
		12050194	209670	1	None	-50	4	Bovine	4.1	pKi	=	4.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	333	5	0	4	3.7	c1ccc(CN2CCN(Cc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL62703	209670	1	None	-50	4	Bovine	4.1	pKi	=	4.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	333	5	0	4	3.7	c1ccc(CN2CCN(Cc3coc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		133633	9021	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
		177	9021	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
		CHEMBL445102	9021	53	None	-100	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptorDisplacement of [3H]SCH23390 from dopamine D1 receptor	ChEMBL	340	3	2	2	4.3	Clc1ccc(cc1)C1(O)CCN(CC1)Cc1c[nH]c2c1cccc2	10.1021/jm800532x
		10378389	210024	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		CHEMBL134807	210024	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		CHEMBL64553	210024	1	None	-14454	7	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	269	4	2	3	2.9	Oc1ccc2c(c1)O[C@@H](CNCc1ccccc1)CC2	10.1021/jm401384w
		156020120	184812	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	340	3	0	5	3.4	COc1cc2c3c(c1OC)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4646927	184812	0	None	-1	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	340	3	0	5	3.4	COc1cc2c3c(c1OC)-c1cc([N+](=O)[O-])ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		15654860	210440	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ncccc32)CC1	10.1021/jm00067a009
		CHEMBL67355	210440	1	None	2	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	293	0	1	5	2.5	CN1CCN(C2=Nc3ccccc3Nc3ncccc32)CC1	10.1021/jm00067a009
		45481840	204838	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	267	4	0	2	4.1	CCCCC1c2cc(OC)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
		CHEMBL574110	204838	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	267	4	0	2	4.1	CCCCC1c2cc(OC)c(Cl)cc2CCN1C	10.1016/j.bmc.2009.05.079
		6852376	98374	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
		CHEMBL1467585	98374	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
		CHEMBL24077	98374	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
		CHEMBL503958	98374	13	None	-3	5	Human	7.1	pKi	=	7.1	Binding	Agonist activity at dopamine D1 receptor (unknown origin)Agonist activity at dopamine D1 receptor (unknown origin)	ChEMBL	255	1	3	3	2.4	Oc1cc2c(cc1O)[C@@H](c1ccccc1)CNCC2	10.1021/ml400373j
		10588326	165645	0	None	17	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
		CHEMBL40950	165645	0	None	17	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	273	0	3	4	2.7	Oc1cc2c(cc1O)[C@@H]1c3ccsc3CN[C@H]1CC2	10.1021/jm970038v
		44436608	153534	0	None	-870	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL392437	153534	0	None	-870	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1cccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		167715	9651	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		969	9651	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		CHEMBL225230	9651	14	None	-954	5	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	2	2	3	3.6	CCCN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm060959i
		3033276	19949	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
		CHEMBL1190928	19949	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
		CHEMBL541867	19949	1	None	-1698	2	Rat	6.1	pKi	=	6.1	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	ChEMBL	307	2	2	3	3.6	Oc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(CC1CC1)CC3	10.1021/jm00163a007
		25139331	176707	0	None	-1	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	310	9	2	2	3.9	CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
		CHEMBL444128	176707	0	None	-1	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	310	9	2	2	3.9	CCCNCCCCNC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm800895v
		24823920	104222	0	None	-26	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
		CHEMBL270056	104222	0	None	-26	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	311	3	0	5	2.2	Fc1cccc(N2CCN(Cc3cnn4ccccc34)CC2)n1	10.1021/jm701375u
		53325137	65368	0	None	-37	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684128	65368	0	None	-37	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	525	10	0	5	6.2	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCCN2CCN(c4ccccc4OC)CC2)c1-3	10.1016/j.bmc.2011.01.053
		10324985	83556	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL199824	83556	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		CHEMBL2068762	83556	8	None	-5495	17	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	423	7	0	8	1.7	COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1	10.1021/jm050725j
		14659294	174768	0	None	-3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	301	0	2	3	3.5	CN1CCc2cc(Cl)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL431946	174768	0	None	-3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	301	0	2	3	3.5	CN1CCc2cc(Cl)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		70692653	82841	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		CHEMBL2057443	82841	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	nan
		70692653	82841	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
		CHEMBL2057443	82841	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	339	2	0	5	3.1	COc1cc2c(c(OC)c1)CN1CCc3cc4c(cc3[C@@H]1C2)OCO4	10.1016/j.bmc.2012.05.057
		129012255	161157	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)C1Cc3c(c(OC)cc(OC)c3OC)CN1CC2	nan
		CHEMBL3987156	161157	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.Radioligand Binding Assay: The affinity of compounds to D1 and D2 dopamine receptors were determined by competition binding assays. Membrane homogenates of HEK293T cells were stably transfected with D1, or D2 receptors. Duplicated tubes were incubated at 30° C. for 50 mins (for D1, and D2) with increasing concentrations of respective compound and with [3H]SCH23390 (for D1 dopamine receptors), or [3H]Spiperone (for dopamine D2 receptor) in a final volume of 200 μL binding buffer containing 50 mM Tris, 4 mM MgCl2, pH 7.4. Nonspecific binding was determined by parallel incubations with either 10 μM SCH23390 for D1, or Spiperone for D2 receptors respectively. The reaction was started by addition of membranes (15 ng/tube) and stopped by rapid filtration through Whatman GF/B glassfiber filter and subsequently washed with cold buffer (50 mM Tris, 5 mM EDTA, pH 7.4) using a Brandel 24-well cell harvester. Scintillation cocktail was added and the radioactivity was determined in a MicroBeta liquid scintillation counter.	ChEMBL	385	5	0	6	3.4	COc1cc2c(cc1OC)C1Cc3c(c(OC)cc(OC)c3OC)CN1CC2	nan
		71454295	90854	0	None	-933	7	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	536	8	0	6	5.5	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207641	90854	0	None	-933	7	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	536	8	0	6	5.5	COc1ccccc1N1CCN(Cc2cc(CN3CCN(c4ccccc4OC)CC3)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		57398875	76089	0	None	-213	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	4.7	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928138	76089	0	None	-213	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1005	30	2	17	4.7	COc1ccccc1N1CCN(CCCNC(=O)c2cnn3ccc(COCCOCCOCCOCCOCc4ccn5ncc(C(=O)NCCCN6CCN(c7ccccc7OC)CC6)c5c4)cc23)CC1	10.1016/j.bmc.2011.10.063
		71474024	151246	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		CHEMBL3906676	151246	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.Reception Binding Assay: Different concentrations (10^−5 M-10^−11 M) of the compound of the invention and corresponding isotope receptor ligand as well as receptor protein were loaded into the reaction tube and incubated in 30° C. water bath for 60 minutes. The reaction was terminated in a refrigerator. The reaction mixture was put in a Millipore filter (millipore) cell sample collector, filtered through suction filtration using GF/C glass fiber filter paper, and dried. The resulting sample was placed into 0.5 mL tube. 500 μL liquid scintillation fluid was added and intensity of radioactivity was determined by counting. For dopamine D1 receptor: isotope receptor ligands [3H] SCH23390 (85.0 Ci/mmol) (D1-selective, purchased from Amersham Corporation), D1 receptor protein expressed in HEK-293 cells; For D2 dopamine receptor: isotope receptor ligands [3H] Spiperone (77.0 Ci/mmol) (D2-selective, purchased from Amersham Corporation); D2 receptor protein expressed in HEK-293 cells; For 5-HT1A receptor: isotope receptor ligands [3H] 8-OH-DPAT; 5-HT1A receptor protein expressed in HEK-293 cells; For 5-HT2A receptor: isotope receptor ligands [3H]-Ketanserin; 5-HT2A receptor protein expressed in HEK-293 cells.	ChEMBL	327	2	2	5	2.8	COc1cc2c(cc1OC)CN1CCc3cc(O)c(O)cc3C1C2	nan
		10551026	108394	0	None	-724	5	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL298875	108394	0	None	-724	5	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	438	5	1	3	4.6	COc1c(C(=O)N[C@@H]2CCN(Cc3ccccc3)C2)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		15691846	211438	0	None	-10	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	335	3	1	3	3.4	O=C1CC(CN2CCC(O)(c3ccccc3)CC2)Cc2ccccc21	10.1021/jm00111a046
		CHEMBL73675	211438	0	None	-10	2	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	335	3	1	3	3.4	O=C1CC(CN2CCC(O)(c3ccccc3)CC2)Cc2ccccc21	10.1021/jm00111a046
		10672006	53593	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	467	5	1	3	5.5	CCCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
		CHEMBL154015	53593	0	None	-	1	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	467	5	1	3	5.5	CCCN1CCc2c(Br)ccc(O)c2C1Cc1cc(OC)ccc1Br	10.1021/jm991034o
		14198588	178286	2	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		CHEMBL446396	178286	2	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCNC2c1ccccc1	10.1021/jm00051a008
		14198589	69848	2	None	35	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@@H]2c1ccccc1	10.1021/jm00118a012
		CHEMBL1788322	69848	2	None	35	2	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nMInhibition of [3H]SCH-23,390 binding to Dopamine receptor D1 at 0.25 nM	ChEMBL	259	1	2	2	3.3	Oc1cc2c(cc1Cl)CCN[C@@H]2c1ccccc1	10.1021/jm00118a012
		9928332	103955	5	None	-371	9	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assayCompound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assay	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/0960-894X(95)00398-D
		CHEMBL268258	103955	5	None	-371	9	Rat	6.1	pKi	=	6.1	Binding	Compound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assayCompound was evaluated for its binding affinity to Dopamine receptor D1 in rat striatum using [3H]- SCH-23390 radioligand assay	ChEMBL	349	6	0	3	5.0	COc1cccc2c1CCC[C@H]2CN(C)CCc1ccc2ccoc2c1	10.1016/0960-894X(95)00398-D
		2585	7590	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		522	7590	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		551	7590	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		CHEMBL723	7590	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		DB01136	7590	103	None	-112	22	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	nan
		10665177	29915	0	None	56	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	344	5	2	3	3.8	NCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL133094	29915	0	None	56	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	344	5	2	3	3.8	NCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		10620219	13790	0	None	46	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	386	8	2	3	4.8	CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL108480	13790	0	None	46	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	386	8	2	3	4.8	CNCCCCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		1353	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		3559	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		86	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		CHEMBL54	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		DB00502	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00030a011
		45482152	204789	0	None	-131	4	Pig	6.1	pKi	=	6.1	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	517	9	1	8	3.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cn(-c2ccc([N+](=O)[O-])cc2)nn1	10.1016/j.bmc.2009.06.041
		CHEMBL573792	204789	0	None	-131	4	Pig	6.1	pKi	=	6.1	Binding	Binding affinity to pig dopamine D1 receptorBinding affinity to pig dopamine D1 receptor	ChEMBL	517	9	1	8	3.8	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cn(-c2ccc([N+](=O)[O-])cc2)nn1	10.1016/j.bmc.2009.06.041
		4420454	63033	6	None	-41	5	Bovine	6.1	pKi	=	6.1	Binding	Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		CHEMBL162762	63033	6	None	-41	5	Bovine	6.1	pKi	=	6.1	Binding	Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.Dissociation constant of compound on one-site model Bovine dopamine receptor D2. Tested for ability to displace the radioligand [3H]spiperone at the binding site.	ChEMBL	205	5	0	1	3.2	C#CC1=CCC(N(CCC)CCC)CC1	10.1021/jm991098z
		44400500	172839	0	None	-380	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		CHEMBL425731	172839	0	None	-380	5	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL		None	None	None		None	10.1021/jm050170s
		10980338	174787	0	None	-2454	4	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3ccc4ccnn4c3)CC2)cc1	10.1021/jm015522j
		CHEMBL432059	174787	0	None	-2454	4	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against dopamine receptor D1 using radioligand [3H]-SCH- 23390	ChEMBL	326	3	0	4	3.3	Clc1ccc(N2CCN(Cc3ccc4ccnn4c3)CC2)cc1	10.1021/jm015522j
		10498094	39092	1	None	-5370	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4Cl)CC3)cc2c1	10.1021/jm0009989
		CHEMBL141035	39092	1	None	-5370	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranesDisplacement of [3H]SCH-23390 from Dopamine receptor D1 of bovine striatal membranes	ChEMBL	350	3	1	3	4.0	N#Cc1ccc2[nH]c(CN3CCN(c4ccccc4Cl)CC3)cc2c1	10.1021/jm0009989
		44412494	85096	0	None	-2630	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	352	4	0	4	3.8	Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL210955	85096	0	None	-2630	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	352	4	0	4	3.8	Clc1ccc(N2CCN(Cc3cnn(-c4ccccc4)c3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		137643132	164829	0	None	-6309	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	503	7	1	7	3.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1	10.1016/j.bmc.2017.04.036
		CHEMBL4085920	164829	0	None	-6309	6	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	503	7	1	7	3.8	CC(C)(C)c1nc(N2CCN(CCCCNC(=O)c3cc4ccccn4n3)CC2)cc(C(F)(F)F)n1	10.1016/j.bmc.2017.04.036
		44381146	65281	0	None	-18	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL168372	65281	0	None	-18	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		11639064	196721	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL458579	196721	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL517028	196721	0	None	-199	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	359	1	3	4	4.2	CN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		156012686	184141	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	352	3	1	4	3.4	COc1cc2c3c(c1OC)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4637673	184141	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	352	3	1	4	3.4	COc1cc2c3c(c1OC)-c1cc(NC(C)=O)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		118711258	120733	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)cc1	10.1016/j.ejmech.2014.07.059
		CHEMBL3325908	120733	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	372	4	2	3	4.9	Cc1ccc(CNc2cc3c(cc2O)C(c2ccccc2)CN(C)CC3)cc1	10.1016/j.ejmech.2014.07.059
		10040938	51134	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	308	0	0	5	2.8	Cc1ccc2c(c1)N=C(N1CCN(C)CC1)c1cccnc1O2	10.1021/jm00030a011
		CHEMBL151809	51134	0	None	1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	308	0	0	5	2.8	Cc1ccc2c(c1)N=C(N1CCN(C)CC1)c1cccnc1O2	10.1021/jm00030a011
		10044041	55717	0	None	-8	2	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	359	1	0	3	4.3	COc1ccc2c(c1)CC1c3c(ccc(Br)c3CCN1C)O2	10.1021/jm991034o
		CHEMBL156011	55717	0	None	-8	2	Rat	5.1	pKi	=	5.1	Binding	Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.Binding Affinity was determined against Dopamine receptor D1 in rat striatal membranes using [3H]- SCH 23390 radioligand.	ChEMBL	359	1	0	3	4.3	COc1ccc2c(c1)CC1c3c(ccc(Br)c3CCN1C)O2	10.1021/jm991034o
		1353	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		3559	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		86	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		CHEMBL54	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		DB00502	8692	93	None	-74	85	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00067a009
		156015018	184350	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	337	2	2	3	4.0	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
		CHEMBL4640497	184350	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	337	2	2	3	4.0	COc1cc2c(cc1O)C(c1c(Cl)cccc1Cl)CNCC2	10.1016/j.bmcl.2020.127305
		129103318	174093	0	None	-107	13	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		CHEMBL4293999	174093	0	None	-107	13	Rat	7.1	pKi	=	7.1	Binding	Displacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from dopamine D1 receptor in rat strriatum homogenates after 20 mins by liquid scintillation counting	ChEMBL	475	7	0	5	5.0	O=C(CCCCN1CCC(c2noc3cc(F)ccc23)CC1)c1cc2c3c(c1)CCN3C(=O)CC2	10.1021/acs.jmedchem.8b01096
		3038495	7495	37	None	-616	18	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
		7625	7495	37	None	-616	18	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
		CHEMBL25236	7495	37	None	-616	18	Human	6.1	pKi	=	6.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm025558r
		3038495	7495	37	None	-616	18	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
		7625	7495	37	None	-616	18	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
		CHEMBL25236	7495	37	None	-616	18	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm060138d
		3038495	7495	37	None	-512	18	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
		7625	7495	37	None	-512	18	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
		CHEMBL25236	7495	37	None	-512	18	Pig	6.1	pKi	=	6.1	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranesInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 of porcine striatal membranes	ChEMBL	417	8	1	4	4.2	COc1ccccc1N1CCN(CC1)CCCCNC(=O)c1ccc2c(c1)cccc2	10.1021/jm050170s
		44263882	104000	0	None	-4	3	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4ccc5ccccc5c34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		CHEMBL268558	104000	0	None	-4	3	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	376	3	0	4	4.5	Clc1ccc(N2CCN(Cc3cnn4ccc5ccccc5c34)CC2)cc1	10.1016/s0960-894x(98)00692-1
		25333445	84898	5	None	-380	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3ccc(-n4cccn4)cc3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		CHEMBL210318	84898	5	None	-380	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membraneDisplacement of [3H]SCH-23390 from dopamine D1 receptor in porcine striatal membrane	ChEMBL	318	4	0	4	3.2	c1ccc(N2CCN(Cc3ccc(-n4cccn4)cc3)CC2)cc1	10.1016/j.bmcl.2006.02.075
		44567596	196562	0	None	-12	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	371	6	3	6	2.2	CN1CCc2cc(OCCOCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		CHEMBL516151	196562	0	None	-12	2	Mouse	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	ChEMBL	371	6	3	6	2.2	CN1CCc2cc(OCCOCCO)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2008.02.038
		126720252	171454	0	None	-269	12	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		CHEMBL4216870	171454	0	None	-269	12	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting methodDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes after 90 mins by scintillation counting method	ChEMBL	697	15	2	6	9.2	NCCCCCCn1cc(CCCCN2CCC(c3ccc(-c4cc(C(=O)O)cc5cc(-c6ccc(C(F)(F)F)cc6)ccc45)cc3)CC2)nn1	10.1021/acs.jmedchem.8b00168
		11222444	136962	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	369	4	0	5	4.1	CC(C)OCc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		CHEMBL367875	136962	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	369	4	0	5	4.1	CC(C)OCc1ccc2n1C=C(N1CCN(C)CC1)c1ccccc1S2	10.1021/jm0309811
		10873978	175265	0	None	-18	5	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		CHEMBL435218	175265	0	None	-18	5	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	445	7	1	4	5.1	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2o1	10.1021/jm0211220
		117774120	139230	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	6	3.3	COC(=O)c1cccnc1Oc1ccc(-c2c(C)n[nH]c(=O)c2C)c(C)c1	nan
		CHEMBL3697592	139230	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	365	4	1	6	3.3	COC(=O)c1cccnc1Oc1ccc(-c2c(C)n[nH]c(=O)c2C)c(C)c1	nan
		26987	7736	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		6063	7736	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		671	7736	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		CHEMBL1626	7736	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		DB00283	7736	33	None	-245	21	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	nan
		11631304	80151	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	330	2	1	1	4.6	c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2	10.1021/jm050846j
		CHEMBL201432	80151	0	None	1	2	Human	6.1	pKi	=	6.1	Binding	Inhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assayInhibition of binding to human D1 receptor expressed in HEK 293 cells by radioligand binding assay	ChEMBL	330	2	1	1	4.6	c1ccc2c(c1)CCN(CC1CC1)CCc1c([nH]c3ccccc13)C2	10.1021/jm050846j
		71817345	98754	0	None	-158	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
		CHEMBL2414992	98754	0	None	-158	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation countingDisplacement of [3H]-SCH23390 from D1 receptor of Wistar rat striatal membranes after 1 hr by liquid scintillation counting	ChEMBL	281	3	2	3	3.5	CN(C)CCc1cc(O)c(O)c2c1ccc1ccccc12	10.1016/j.bmcl.2013.06.078
		1588	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		28864	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		43	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		CHEMBL157138	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		DB00589	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	10.1021/jm9800292
		117949705	121975	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	4	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344468	121975	0	None	-4	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	363	4	1	4	4.3	COc1cc2c(cc1O)[C@@H]1Cc3sc(CCCCl)cc3CN1CC2	10.1016/j.bmc.2014.09.024
		134150400	158759	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	397	7	2	5	4.7	CCCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3966718	158759	0	None	2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	397	7	2	5	4.7	CCCCCCOc1c(O)ccc2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		44436618	154701	0	None	-512	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1ccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL393365	154701	0	None	-512	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1ccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		11581237	145736	0	None	-4897	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	357	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1	10.1021/jm060166w
		CHEMBL378515	145736	0	None	-4897	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	357	4	0	6	2.7	COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1	10.1021/jm060166w
		137637428	163015	0	None	-9	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	250	1	1	5	0.9	CN1CCN(c2ccc(O)c3c2OCCO3)CC1	10.1016/j.bmc.2017.08.037
		CHEMBL4064759	163015	0	None	-9	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	250	1	1	5	0.9	CN1CCN(c2ccc(O)c3c2OCCO3)CC1	10.1016/j.bmc.2017.08.037
		72545010	99900	0	None	-229	5	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CF)[C@@H](O)[C@H](O)[C@H]3O)nn2)CC1	10.1016/j.bmcl.2013.09.026
		CHEMBL2443003	99900	0	None	-229	5	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	437	6	3	10	-0.4	COc1ccccc1N1CCN(Cc2cn([C@@H]3O[C@H](CF)[C@@H](O)[C@H](O)[C@H]3O)nn2)CC1	10.1016/j.bmcl.2013.09.026
		11091738	124870	0	None	-22	5	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
		CHEMBL340641	124870	0	None	-22	5	Rat	5.1	pKi	=	5.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2ccc(Cl)cc2Cl)CC1)c1cc2ccccc2cn1	10.1021/jm0211220
		11102533	24829	0	None	-13	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	457	8	1	6	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2nc3ccccc3n3cccc23)CC1	10.1021/jm0211220
		CHEMBL126590	24829	0	None	-13	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	457	8	1	6	3.8	COc1ccccc1N1CCN(CCCCNC(=O)c2nc3ccccc3n3cccc23)CC1	10.1021/jm0211220
		2274	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		4917	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		7279	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		CHEMBL728	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		DB00433	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	nan
		44568533	195623	0	None	8	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	280	1	1	3	3.0	COc1cc2c3c(c1)-c1c(N)cccc1C[C@H]3N(C)CC2	10.1016/j.bmc.2008.05.077
		CHEMBL506721	195623	0	None	8	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells	ChEMBL	280	1	1	3	3.0	COc1cc2c3c(c1)-c1c(N)cccc1C[C@H]3N(C)CC2	10.1016/j.bmc.2008.05.077
		10758744	107283	0	None	11	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL291100	107283	0	None	11	2	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		162653702	187283	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
		CHEMBL4753299	187283	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human dopamine D1 receptorBinding affinity to human dopamine D1 receptor	ChEMBL	337	1	1	3	5.2	C[C@@H]1C=C(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CCN1C	10.1016/j.bmcl.2020.127563
		11699469	84427	0	None	-48	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	537	8	1	5	5.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1	10.1021/jm060138d
		CHEMBL208847	84427	0	None	-48	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	537	8	1	5	5.7	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3c4ccc(c3o2)CCc2ccc(cc2)CC4)CC1	10.1021/jm060138d
		49783041	23943	0	None	-1949	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	597	7	1	3	6.8	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1256171	23943	0	None	-1949	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	597	7	1	3	6.8	O=C(NCCCCN1CCN(c2cc3ccc2CCc2ccc(cc2)CC3)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		10826543	16873	0	None	-85	3	Rat	6.1	pKi	=	6.1	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	1	2	3.7	CCc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		CHEMBL115524	16873	0	None	-85	3	Rat	6.1	pKi	=	6.1	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	279	1	1	2	3.7	CCc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1021/jm960188q
		277	8083	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		2913	8083	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		765	8083	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		CHEMBL516	8083	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		DB00434	8083	62	None	-33	50	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	nan
		44415382	87882	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	4	1	5	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL215611	87882	0	None	7	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	473	4	1	5	4.8	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)CCc3ccccc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		135398745	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		47	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		CHEMBL715	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		DB00334	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	pKi value for Dopamine receptor D1 binding sitepKi value for Dopamine receptor D1 binding site	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		44241718	202043	0	None	-281	4	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	393	4	1	7	1.6	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccn4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		CHEMBL551199	202043	0	None	-281	4	Bovine	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	393	4	1	7	1.6	Cn1c(N2CCCC2)nc2c(CN3CCN(c4ccccn4)CC3)c[nH]c2c1=O	10.1016/j.bmc.2009.05.015
		10709445	108140	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115377	108140	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL296993	108140	0	None	26	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		90644064	118813	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	7	0	4	5.0	Clc1ccc(N2CCN(CCCCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		CHEMBL3289649	118813	0	None	-66	4	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	383	7	0	4	5.0	Clc1ccc(N2CCN(CCCCCc3nc4ccccc4o3)CC2)cc1	10.1016/j.bmc.2014.04.026
		154724609	183378	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4514800	183378	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		CHEMBL4597637	183378	1	None	-9	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	440	10	0	6	4.8	COc1ccc(F)cc1C1CC1CN(C)CCCSc1nnc(-c2ccccc2)n1C	10.1021/acs.jmedchem.9b01835
		53325242	63844	0	None	-4	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		CHEMBL1644978	63844	0	None	-4	17	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	ChEMBL	537	8	1	2	7.9	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2018.10.036
		15981509	148736	1	None	316	2	Pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
		CHEMBL387250	148736	1	None	316	2	Pig	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenateDisplacement of [3H]SCH-23390 from dopamine D1-like receptor in porcine striata homogenate	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CO2	10.1021/jm0604979
		130907	201462	5	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
		CHEMBL53294	201462	5	None	-7	4	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	ChEMBL	325	3	2	4	3.6	CCCN1CCc2cc(OC)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/ml1001689
		10448562	121898	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL334350	121898	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		9995986	35042	1	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL137420	35042	1	None	-	1	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@H]1c1ccccc1	10.1021/jm00051a008
		10448562	121898	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL334350	121898	1	None	12	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	317	1	1	2	3.7	CN1CCc2cc(Br)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		117773687	139207	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.6	C=C(C)c1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		CHEMBL3697570	139207	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	363	4	1	5	3.6	C=C(C)c1cccnc1Oc1ccc(-c2c(C)c(=O)[nH]c(=O)n2C)c(C)c1	nan
		130442534	173676	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		CHEMBL4286177	173676	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	341	3	0	5	5.2	Cc1ccc2nccn2c1-c1ccc(Oc2nccc3occc23)cc1	10.1021/acs.jmedchem.8b01622
		10851849	176712	0	None	16	2	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		CHEMBL44414	176712	0	None	16	2	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	301	1	3	4	3.3	CCc1cc2c(s1)[C@H]1c3cc(O)c(O)cc3CC[C@@H]1NC2	10.1021/jm970038v
		13372	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		86764100	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		CHEMBL3697617	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		DB14899	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	nan
		13372	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	10.1021/acs.jmedchem.8b01767
		86764100	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	10.1021/acs.jmedchem.8b01767
		CHEMBL3697617	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	10.1021/acs.jmedchem.8b01767
		DB14899	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	Partial agonist activity at human D1RPartial agonist activity at human D1R	ChEMBL	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	10.1021/acs.jmedchem.8b01767
		9818423	115026	0	None	34	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	281	0	3	3	3.0	Cc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
		CHEMBL319707	115026	0	None	34	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	281	0	3	3	3.0	Cc1ccc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/j.ejmech.2011.11.039
		15937719	25584	0	None	72	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	249	1	1	2	2.6	C#CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		CHEMBL127843	25584	0	None	72	2	Rat	8.1	pKi	=	8.1	Binding	Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.Binding affinity towards Dopamine receptor D1 in rat striatal tissue by [3H]-SCH- 23390 displacement.	ChEMBL	249	1	1	2	2.6	C#CCC1CN(C)CCc2cc(Cl)c(O)cc21	10.1016/S0960-894X(00)80155-9
		11522339	82027	1	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
		CHEMBL203689	82027	1	None	-2	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2c(O)cccc2CC1	10.1021/jm051237e
		173871	10386	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
		936	10386	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
		CHEMBL1193571	10386	2	None	-4	3	Human	8.1	pKi	=	8.1	Binding	The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1The compound was evaluated for the dissociation constant for inhibiting the binding of [3H]-SCH- 23390 at dopamine receptor D1	ChEMBL	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	10.1021/jm00116a004
		75201901	173204	19	None	-1	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		CHEMBL4277264	173204	19	None	-1	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	356	3	0	6	4.9	Cc1cc(Oc2nccc3occc23)ccc1-c1c(C)ncc2nccn12	10.1021/acs.jmedchem.8b01622
		11716438	147660	1	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
		CHEMBL382010	147660	1	None	5	4	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	267	0	1	2	3.0	CN1CCc2ccccc2Cc2cc(O)ccc2CC1	10.1021/jm051237e
		163091	7282	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
		22	7282	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
		CHEMBL504548	7282	34	None	-147	10	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assayDisplacement of [3H]SCH-23390 from human cloned D1 dopamine receptor expressed in HEKT cells incubated for 90 mins by scintillation counting based radioligand binding assay	ChEMBL	285	0	0	2	4.3	Clc1ccc2c(c1)[C@H]1CN(C[C@@H]1c1c(O2)cccc1)C	10.1039/C5MD00258C
		6603797	74793	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL1257041	74793	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL19130	74793	4	None	-2089	3	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		44447997	102517	0	None	-20	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	4	0	3	3.9	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1cccc(OC=O)c1-3	10.1021/jm060959i
		CHEMBL258372	102517	0	None	-20	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	325	4	0	3	3.9	CCCN1CCc2cc(F)cc3c2[C@H]1Cc1cccc(OC=O)c1-3	10.1021/jm060959i
		9888555	172383	16	None	-3235	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		CHEMBL424294	172383	16	None	-3235	8	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm900095y
		137651936	164171	0	None	-1000	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4078348	164171	0	None	-1000	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccn2nccc2c1)[C@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		145990453	173724	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	404	7	2	4	4.1	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc3ccccc3c1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4287062	173724	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	404	7	2	4	4.1	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc3ccccc3c1)CC2	10.1021/acsmedchemlett.8b00229
		145993377	173747	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	430	8	2	4	4.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2	10.1021/acsmedchemlett.8b00229
		CHEMBL4287471	173747	0	None	-295	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranesDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEKT cell membranes	ChEMBL	430	8	2	4	4.6	COc1cc2c(cc1O)CN(CCCCNC(=O)c1ccc(-c3ccccc3)cc1)CC2	10.1021/acsmedchemlett.8b00229
		70690652	83345	0	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccc(Br)cc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
		CHEMBL2062857	83345	0	None	-3	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	442	7	1	3	4.6	CCN(CC)[C@@H]1[C@@H]2[C@@H](CN(Cc3ccccc3)[C@H]2c2ccc(Br)cc2)[C@H]1CO	10.1016/j.ejmech.2012.07.025
		12050202	210077	0	None	-204	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CN[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL64752	210077	0	None	-204	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	441	7	1	5	4.5	COc1ccc(Br)cc1-c1nc(CN[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		44329067	214785	0	None	-154	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2ccc(C=O)c2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL97319	214785	0	None	-154	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	248	6	0	3	2.7	CCCN(CCC)[C@@H]1CCn2ccc(C=O)c2C1	10.1016/s0960-894x(01)00564-9
		1240	15595	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL109684	15595	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		CHEMBL1256754	15595	17	None	-870	4	Human	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	309	6	1	2	4.2	CCCN(CCc1ccccc1)C1CCc2c(O)cccc2C1	10.1021/jm00115a012
		44415758	86821	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	521	4	1	5	6.1	CC(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL212950	86821	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	521	4	1	5	6.1	CC(C)CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3Cl)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		57391896	76080	0	None	-125	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1013	36	2	15	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928129	76080	0	None	-125	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	1013	36	2	15	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		10758745	107209	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL2115373	107209	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		CHEMBL290438	107209	0	None	18	2	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligandIn vitro binding affinity against Dopamine receptor D1 like from rat caudate membrane using [125I]-SCH as radioligand	ChEMBL	329	0	3	4	4.0	CC(C)(C)c1cc2c(s1)CN[C@H]1CCc3cc(O)c(O)cc3[C@H]21	10.1021/jm970038v
		10427977	61239	0	None	-660	4	Bovine	6.1	pKi	=	6.1	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	350	3	0	4	3.3	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		CHEMBL160952	61239	0	None	-660	4	Bovine	6.1	pKi	=	6.1	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	350	3	0	4	3.3	C#Cc1cccc2c(CN3CCN(c4ccc(Cl)cc4)CC3)cnn12	10.1016/s0960-894x(01)00814-9
		57395341	76086	0	None	-426	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	2.8	CCOCCOCc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		CHEMBL1928135	76086	0	None	-426	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	495	13	1	8	2.8	CCOCCOCc1ccn2ncc(C(=O)NCCCN3CCN(c4ccccc4OC)CC3)c2c1	10.1016/j.bmc.2011.10.063
		9842468	16681	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
		CHEMBL114375	16681	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm960143p
		9842468	16681	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		CHEMBL114375	16681	0	None	4	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.Binding affinity against dopamine receptor D1 from rat striatal membranes using [3H]-SCH- 23390 as radioligand.	ChEMBL	372	6	1	3	4.4	CN(C)CCCCN1CCc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00021a018
		10088453	72849	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1016/j.bmcl.2004.06.005
		CHEMBL183776	72849	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1Binding affinity against Dopamine receptor D1	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1016/j.bmcl.2004.06.005
		10088453	72849	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1007/s00044-012-0055-5
		CHEMBL183776	72849	0	None	-151	5	Human	6.1	pKi	=	6.1	Binding	Binding affinity to dopamine D1 receptor (unknown origin)Binding affinity to dopamine D1 receptor (unknown origin)	ChEMBL	337	5	1	5	2.3	COc1ccccc1N1CCN(CCc2ccc3[nH]nnc3c2)CC1	10.1007/s00044-012-0055-5
		9972693	175304	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cccnc3Sc3ccccc32)CC1	10.1021/jm00030a011
		CHEMBL435441	175304	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	310	0	0	5	2.9	CN1CCN(C2=Nc3cccnc3Sc3ccccc32)CC1	10.1021/jm00030a011
		76321554	113180	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		CHEMBL3115574	113180	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		CHEMBL3139450	113180	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		14198577	204895	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	0	2	3.9	COc1cc2c(cc1Cl)CCN(C)C2c1ccccc1	10.1016/j.bmc.2009.05.079
		CHEMBL574557	204895	0	None	2	2	Rat	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor in Wistar rat striatal membrane by liquid scintillation counting	ChEMBL	287	2	0	2	3.9	COc1cc2c(cc1Cl)CCN(C)C2c1ccccc1	10.1016/j.bmc.2009.05.079
		154726353	183102	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4577162	183102	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595382	183102	1	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	467	12	2	3	5.9	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		1353	8692	93	None	-38	85	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		3559	8692	93	None	-38	85	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		86	8692	93	None	-38	85	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		CHEMBL54	8692	93	None	-38	85	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		DB00502	8692	93	None	-38	85	Human	7.1	pKi	=	7.1	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm049720x
		11500677	147626	1	None	-6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		CHEMBL381946	147626	1	None	-6	4	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	281	1	0	2	3.3	COc1ccc2c(c1)Cc1ccccc1CCN(C)CC2	10.1021/jm051237e
		117773662	139217	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	3.7	CCc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697580	139217	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	387	5	1	5	3.7	CCc1c(-c2ccc(Oc3ncccc3C(F)F)cc2C)n(C)c(=O)[nH]c1=O	nan
		86764101	139255	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
		CHEMBL3697618	139255	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cnc(Oc2ccc(-c3c(C)c(=O)[nH]c(=O)n3C)c(C)c2)c(Cl)c1	nan
		117773616	139192	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.1	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697555	139192	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	4	1	5	3.1	CCc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
		117773980	139210	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	2	6	2.3	Cc1cc(Oc2ncccc2O)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697573	139210	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	339	3	2	6	2.3	Cc1cc(Oc2ncccc2O)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44393393	130451	0	None	-575	5	Pig	6.1	pKi	=	6.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	537	7	1	4	5.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)s1	10.1016/j.bmcl.2004.05.052
		CHEMBL362101	130451	0	None	-575	5	Pig	6.1	pKi	=	6.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	537	7	1	4	5.0	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(I)s1	10.1016/j.bmcl.2004.05.052
		9888555	172383	16	None	-3548	8	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm100899z
		CHEMBL424294	172383	16	None	-3548	8	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	423	8	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3s2)CC1	10.1021/jm100899z
		44340084	15860	0	None	-2238	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		CHEMBL109912	15860	0	None	-2238	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	401	6	2	4	4.0	CNc1cc(OC)c(C(=O)N[C@H]2CCN(Cc3ccccc3)C[C@@H]2C)cc1Cl	10.1016/s0960-894x(03)00678-4
		56597938	10712	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		7651	10712	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL2165126	10712	3	None	-870	9	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	461	7	1	4	5.2	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCCN(CC1)c1cccc(c1Cl)Cl	nan
		117772974	139206	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	414	4	1	6	3.0	Cc1cc(Oc2ncccc2N2CC(F)(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697569	139206	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	414	4	1	6	3.0	Cc1cc(Oc2ncccc2N2CC(F)(F)C2)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44415648	86945	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213472	86945	0	None	15	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	489	2	1	7	4.2	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3ccc4c(c3)OCO4)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		17755868	149896	1	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	0	1	2	3.8	CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1	10.1021/jm070388+
		CHEMBL389559	149896	1	None	1	5	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptorDisplacement of [3H]SCH 23390 from human dopamine D1 receptor	ChEMBL	295	0	1	2	3.8	CN1CCCc2ccccc2Cc2ccc(O)cc2CCC1	10.1021/jm070388+
		44401243	175273	0	None	-34	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		CHEMBL435301	175273	0	None	-34	9	Human	7.1	pKi	=	7.1	Binding	Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to human Dopamine receptor D1	ChEMBL	329	2	0	3	4.6	CN(C)C[C@H]1CC2c3ccccc3Oc3ccc(Cl)cc3[C@H]2O1	10.1021/jm049632c
		156022132	184996	0	None	-3	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	4	1	4	3.6	C=CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		CHEMBL4649785	184996	0	None	-3	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	336	4	1	4	3.6	C=CCOc1c(OC)cc2c3c1-c1cc(N)ccc1CC3N(C)CC2	10.1016/j.bmcl.2020.127053
		10085358	116996	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
		CHEMBL323771	116996	0	None	-	1	Rat	6.1	pKi	=	6.1	Binding	Binding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranesBinding affinity towards dopamine receptor D1 using [3H]SCH-23390 was determined in rat striatal membranes	ChEMBL	285	0	1	2	3.5	Oc1cc2c(cc1Cl)CCN1CCc3ccccc3C21	10.1021/jm00051a008
		44448064	101649	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		CHEMBL253947	101649	0	None	1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	10.1021/jm060959i
		44264641	211581	1	None	-11	3	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	230	2	0	4	1.1	CN1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
		CHEMBL7505	211581	1	None	-11	3	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	230	2	0	4	1.1	CN1CCN(Cc2cnn3ccccc23)CC1	10.1016/s0960-894x(98)00692-1
		44329293	116845	0	None	-75	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
		CHEMBL323557	116845	0	None	-75	3	Bovine	4.1	pKi	=	4.1	Binding	In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.In vitro ability to displace [3H]SCH-23390 from bovine cloned Dopamine receptor D1 stably expressed in CHO cells.	ChEMBL	234	5	0	2	3.2	CCCN(CCC)[C@@H]1CCn2cc(C)cc2C1	10.1016/s0960-894x(01)00564-9
		145968810	171817	0	None	-120	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
		CHEMBL4226226	171817	0	None	-120	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	381	8	2	4	3.5	CN(C)c1ccc(C(=O)NCCCCN2CCC(c3cccc(O)c3)C2)cc1	10.1016/j.bmcl.2018.03.084
		154725813	183305	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4568916	183305	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4597047	183305	1	None	-31	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	475	12	1	3	6.4	CCCN(CCCCNC(=O)c1ccc(-c2ccccn2)cc1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		127031404	145580	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	4	2	5	3.2	COc1cc2c(cc1O)C(C)N(Cc1cccc(O)c1OC)CC2	10.1016/j.bmc.2016.03.037
		CHEMBL3780975	145580	0	None	1	3	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH2390 from human dopamine D1 receptor by PDSP assay	ChEMBL	329	4	2	5	3.2	COc1cc2c(cc1O)C(C)N(Cc1cccc(O)c1OC)CC2	10.1016/j.bmc.2016.03.037
		136043856	86882	0	None	-4	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	438	2	1	4	5.6	Fc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(F)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL213200	86882	0	None	-4	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	438	2	1	4	5.6	Fc1ccc(CN2CCN(C3=Nc4cc(Cl)ccc4Nc4ccccc43)CC2)c(F)c1	10.1016/j.bmcl.2006.06.034
		71062708	161085	0	None	-47	12	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		CHEMBL3986651	161085	0	None	-47	12	Mouse	5.1	pKi	=	5.1	Binding	Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.Radioligand Binding Assay: The detailed experimental protocols for the radioligand and functional receptor assays are available on the NIMH PDSP website at http://pdsp.med.unc.edu/UNC-CH %20Protocol %20Book.pdf. A. Serotonin receptors: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT6 and 5-HT7. Assay Buffer: Standard Binding Buffer (50 mM Tris-HCl, 10 mM MgCl2, 1 mM EDTA, pH 7.4) Membrane Fraction Source: Transiently or stably transfected cell lines (e.g., HEK293, COS, CHO, NIH3T3). Protocol adapted from Roth et al. (1986), J. Pharmacol. Exp. Ther., 238(2): 480-485; and Roth et al. (1994), J. Pharmacol. Exp. Ther., 268(3): 1403-1410. Adrenergic Receptors: alpha1A, alpha1B, alpha2A, alpha2B, alpha2C, beta1, beta2, beta3 Assay Buffers: For alpha1 receptors, alpha1 Binding Buffer (20 mM Tris-HCl, 145 mM NaCl, pH 7.4); for alpha2 receptors, alpha2 Binding Buffer (50 mM Tris-HCl, 5 mM MgCl2, pH 7.7); for beta receptors.	ChEMBL	368	7	0	5	2.8	COc1cccc(OC[C@@H]2CN(CCN3CCc4ccccc43)CCO2)c1	nan
		90644060	118808	0	None	-64	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	358	4	0	2	4.4	Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmc.2014.04.026
		CHEMBL3289644	118808	0	None	-64	4	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor by PDSP assay	ChEMBL	358	4	0	2	4.4	Fc1ccc2c(c1)CC(CCN1CCN(c3ccc(Cl)cc3)CC1)C2	10.1016/j.bmc.2014.04.026
		103	10925	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		2875	10925	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		5736	10925	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		CHEMBL285802	10925	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		DB09225	10925	61	None	-28	53	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	ChEMBL	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	10.1021/jm030480f
		1248739	146864	16	None	-190	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	310	3	0	4	2.8	Fc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
		CHEMBL380054	146864	16	None	-190	6	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	310	3	0	4	2.8	Fc1ccc(N2CCN(Cc3cn4ccccc4n3)CC2)cc1	10.1021/jm060166w
		44339984	174576	0	None	-186	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		CHEMBL430522	174576	0	None	-186	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	ChEMBL	452	5	1	3	4.9	COc1c(C(=O)N[C@H]2CN(Cc3ccccc3)C[C@@H]2C)cc(Br)c2ccccc12	10.1016/s0960-894x(03)00678-4
		135524323	202205	0	None	-3467	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	382	5	2	6	1.6	COc1ccccc1N1CCN(Cc2cc3c(=O)[nH]c(N(C)C)nc3[nH]2)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL552268	202205	0	None	-3467	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	382	5	2	6	1.6	COc1ccccc1N1CCN(Cc2cc3c(=O)[nH]c(N(C)C)nc3[nH]2)CC1	10.1016/j.bmc.2009.05.015
		45272537	203305	0	None	-588	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
		CHEMBL563614	203305	0	None	-588	4	Bovine	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	365	4	0	6	3.0	COc1ccccc1N1CCN(Cc2c(C)nc3cc(C)nc(C)n23)CC1	10.1016/j.bmc.2009.05.015
		135398745	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		47	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		CHEMBL715	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		DB00334	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Binding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenateBinding affinity which represents concentration giving half-maximal inhibition of [3H]SCH-23390 (Dopamine receptor D1) binding to rat tissue homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm9706832
		44415804	88250	0	None	147	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL215997	88250	0	None	147	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		135398745	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		47	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		CHEMBL715	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		DB00334	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		135398745	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		47	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		CHEMBL715	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		DB00334	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	In vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligandIn vitro binding affinity towards Dopamine receptor D1 in rat tissue homogenate using [3H]-SCH- 23390 as radioligand	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm0309811
		135398745	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
		47	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
		CHEMBL715	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
		DB00334	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Inhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptorInhibition of [3H]-SCH- 23390 binding to rat dopamine D1 receptor	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm049629t
		135398745	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		47	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		CHEMBL715	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		DB00334	9688	112	None	-23	65	Rat	7.1	pKi	=	7.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	ChEMBL	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	10.1021/jm010982y
		15627811	201711	1	None	-8	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL54183	201711	1	None	-8	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	283	0	3	4	2.6	CN1CCc2cc(O)cc3c2[C@@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		44405980	78831	0	None	-23	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
		CHEMBL197656	78831	0	None	-23	3	Human	5.1	pKi	=	5.1	Binding	Binding affinity to dopamine D1 receptorBinding affinity to dopamine D1 receptor	ChEMBL	479	6	2	6	3.2	COc1ccccc1-c1cc2c(=O)n(CCN3CCN(c4ccccc4Cl)CC3)c(=O)[nH]c2[nH]1	10.1016/j.bmcl.2005.09.027
		1588	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		28864	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		43	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		CHEMBL157138	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		DB00589	9105	27	None	-131	44	Human	7.1	pKi	=	7.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	nan
		44415606	86891	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
		CHEMBL213239	86891	0	None	16	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	475	3	1	6	4.5	COc1cccc(C(=O)NN2c3ccccc3N=C(N3CCN(C)CC3)c3cc(Cl)ccc32)c1	10.1016/j.bmcl.2006.06.034
		44415823	148235	0	None	331	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccncc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL384248	148235	0	None	331	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	446	2	1	6	3.9	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccncc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.034
		44415473	86697	0	None	22	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	437	1	1	5	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212486	86697	0	None	22	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	437	1	1	5	3.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(F)(F)F)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		118709177	120202	0	None	-16	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1135	31	0	14	12.5	O=C(CCc1cn(CCCCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318850	120202	0	None	-16	4	Pig	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1135	31	0	14	12.5	O=C(CCc1cn(CCCCCCCCCCn2cc(CCC(=O)OC3(c4ccc(Cl)cc4)CCN(CCCC(=O)c4ccc(F)cc4)CC3)nn2)nn1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		86764213	139228	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	1	5	4.2	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697590	139228	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	1	5	4.2	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		15711850	20011	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL1191350	20011	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		CHEMBL542436	20011	0	None	-1	5	Rat	7.1	pKi	=	7.1	Binding	Binding affinity for dopamine receptor D1Binding affinity for dopamine receptor D1	ChEMBL	275	2	2	3	3.2	Cc1ccc2c(c1O)C[C@@H](C1CCCCC1)O[C@H]2CN	10.1021/jm00114a002
		117949627	121934	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	287	1	1	4	3.1	COc1cc2c(cc1O)[C@@H]1Cc3sccc3CN1CC2	10.1016/j.bmc.2014.09.024
		CHEMBL3344356	121934	0	None	1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysisDisplacement of [3H]SCH23390 from D1 receptor (unknown origin) transfected in HEK293T cells after 50 mins by liquid scintillation counting analysis	ChEMBL	287	1	1	4	3.1	COc1cc2c(cc1O)[C@@H]1Cc3sccc3CN1CC2	10.1016/j.bmc.2014.09.024
		44436621	97806	0	None	-151	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		CHEMBL239733	97806	0	None	-151	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	443	8	1	3	4.7	C#Cc1cccc(C(=O)NCCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)c1	10.1016/j.bmc.2007.08.038
		71456045	90848	0	None	-1202	6	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	362	5	1	4	3.6	COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		CHEMBL2207635	90848	0	None	-1202	6	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysisDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes after 60 mins by scintillation counting analysis	ChEMBL	362	5	1	4	3.6	COc1ccccc1N1CCN(Cc2cc(CO)c3cccccc2-3)CC1	10.1016/j.bmcl.2012.09.064
		127046952	146879	0	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	421	12	3	5	4.5	COc1cc(CCNCCc2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800636	146879	0	None	-70	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	421	12	3	5	4.5	COc1cc(CCNCCc2ccc(O)c(O)c2)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		25093832	162659	0	None	-2290	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4060461	162659	0	None	-2290	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	423	9	1	8	3.1	COc1ccccc1N1CCN(CCCCOc2ccn3ncc(/C=N/O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		137640391	163484	0	None	-1096	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	418	7	1	7	2.8	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4070091	163484	0	None	-1096	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	418	7	1	7	2.8	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(C#N)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		137635364	163039	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		CHEMBL4064974	163039	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		CHEMBL4074669	163039	0	None	-2754	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranesDisplacement of [3H]SCH23990 from human D1 receptor expressed in HEK293T cell membranes	ChEMBL	439	10	1	6	3.0	O=C(NCCCCN1CCN(c2ccccc2OCCF)CC1)c1cc2ccccn2n1	10.1016/j.bmc.2017.04.036
		10314824	42154	1	None	-8511	5	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm0009989
		CHEMBL143761	42154	1	None	-8511	5	Bovine	5.1	pKi	=	5.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm0009989
		10314824	42154	1	None	-8511	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm060166w
		CHEMBL143761	42154	1	None	-8511	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	334	3	1	3	3.5	N#Cc1ccc2[nH]c(CN3CCN(c4ccc(F)cc4)CC3)cc2c1	10.1021/jm060166w
		44448060	162023	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
		CHEMBL402735	162023	0	None	-1	2	Rat	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	10.1021/jm060959i
		137657153	166336	0	None	-776	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		CHEMBL4102616	166336	0	None	-776	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	393	9	1	5	4.5	CCCN(CCCCOc1ccc2ccnn2c1)[C@@H]1CCc2c(O)cccc2C1	10.1021/acs.jmedchem.6b01857
		85658088	171782	0	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	219	4	1	2	3.0	CCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		CHEMBL4225830	171782	0	None	-2	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cell membranes by radioligand binding assay	ChEMBL	219	4	1	2	3.0	CCCCN1CCC(c2cccc(O)c2)C1	10.1016/j.bmcl.2018.03.084
		1043	8363	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		149	8363	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		8223	8363	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		CHEMBL442	8363	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		DB00696	8363	14	None	-9549	29	Human	6.1	pKi	=	6.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	581	4	3	6	2.0	O=C([C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	nan
		135986088	184894	0	None	-263	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	543	7	1	6	6.5	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2	10.1016/j.bmcl.2008.09.012
		CHEMBL464811	184894	0	None	-263	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	543	7	1	6	6.5	Clc1ccc2c(c1)N=C(N1CCN(Cc3ccc(OCCCN4CCCCC4)cc3)CC1)c1ccccc1N2	10.1016/j.bmcl.2008.09.012
		76321554	113180	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		CHEMBL3115574	113180	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		CHEMBL3139450	113180	0	None	-5370	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 2 hrs by scintillation counting analysis	ChEMBL	395	4	2	3	3.5	Oc1ccc2c(c1)O[C@@H](CNCc1ccc(I)cc1)CC2	10.1021/jm401384w
		112500029	139244	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	0	6	3.9	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)ncc(=O)n1C	nan
		CHEMBL3697606	139244	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	373	5	0	6	3.9	Cc1cc(Oc2ncccc2OC(F)F)ccc1-c1c(C)ncc(=O)n1C	nan
		14198596	108420	0	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		CHEMBL299056	108420	0	None	2	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2C(c2ccccc2)C1	10.1021/jm00051a008
		14198597	108901	1	None	3	2	Human	7.1	pKi	=	7.1	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00129a006
		CHEMBL302393	108901	1	None	3	2	Human	7.1	pKi	=	7.1	Binding	Binding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligandBinding potency of compound for Dopamine receptor D1 by displacing [3H]SCH-23390 radioligand	ChEMBL	273	1	1	2	3.6	CN1Cc2cc(Cl)c(O)cc2[C@H](c2ccccc2)C1	10.1021/jm00129a006
		117772840	139214	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	343	3	1	5	2.9	Cc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
		CHEMBL3697577	139214	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	343	3	1	5	2.9	Cc1c(-c2ccc(Oc3ncccc3Cl)cc2)n(C)c(=O)[nH]c1=O	nan
		44320129	174673	0	None	-1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		CHEMBL431220	174673	0	None	-1	2	Rat	6.1	pKi	=	6.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	251	4	3	4	2.2	CCCCC1Cc2c(ccc(O)c2O)[C@H](CN)O1	10.1021/jm00112a034
		16105548	89473	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
		CHEMBL217964	89473	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
		CHEMBL221652	89473	0	None	-2344	5	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from porcine dopamine D1 in porcine striatal membrane	ChEMBL	462	9	1	5	4.2	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cccc(F)n3)cc2)CC1	10.1021/jm0611152
		53363200	70627	0	None	-134	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	509	14	0	9	3.7	CCOCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		CHEMBL1803052	70627	0	None	-134	4	Pig	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	509	14	0	9	3.7	CCOCCn1cc(CCCOc2ccc(CN3CCN(c4ccccc4OC)CC3)cc2OC)nn1	10.1021/jm2004859
		11682812	84984	0	None	-5495	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	402	5	0	7	3.2	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1	10.1021/jm060166w
		CHEMBL210551	84984	0	None	-5495	4	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	ChEMBL	402	5	0	7	3.2	COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1	10.1021/jm060166w
		2	10035	23	None	-977	28	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
		54562	10035	23	None	-977	28	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
		CHEMBL240773	10035	23	None	-977	28	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1016/j.bmc.2016.04.028
		2	10035	23	None	-977	28	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
		54562	10035	23	None	-977	28	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
		CHEMBL240773	10035	23	None	-977	28	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysis	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm501889t
		44380716	65861	0	None	-12	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		CHEMBL169631	65861	0	None	-12	4	Bovine	4.1	pKi	=	4.1	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	429	7	1	4	3.6	COc1cc(N(C)C(C)=O)c(Cl)cc1C(=O)NC[C@H]1CCN(Cc2ccccc2)C1	10.1016/s0960-894x(99)00086-4
		2	10035	23	None	-16595	28	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
		54562	10035	23	None	-16595	28	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
		CHEMBL240773	10035	23	None	-16595	28	Pig	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in porcine striatal membranes	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm400520c
		2	10035	23	None	-977	28	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
		54562	10035	23	None	-977	28	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
		CHEMBL240773	10035	23	None	-977	28	Human	4.1	pKi	=	4.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	10.1021/jm5004039
		44582179	188204	0	None	-57	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	379	6	0	5	2.5	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476393	188204	0	None	-57	3	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	379	6	0	5	2.5	O=C1c2ccccc2CCCN1CCCCN1CCN(c2ncccn2)CC1	10.1016/j.bmcl.2009.01.067
		154706431	183364	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4531363	183364	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4597531	183364	1	None	-77	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	451	12	2	3	5.3	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		1220	6975	55	None	-69183	44	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
		31	6975	55	None	-69183	44	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
		7	6975	55	None	-69183	44	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
		CHEMBL56	6975	55	None	-69183	44	Bovine	4.1	pKi	=	4.1	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	ChEMBL	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	10.1021/jm950759z
		44591012	182359	0	None	-177	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		CHEMBL457957	182359	0	None	-177	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	10.1016/j.bmcl.2008.09.012
		44386883	67174	0	None	-1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	328	3	1	4	3.2	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CNCC2	10.1016/s0960-894x(98)00138-3
		CHEMBL174949	67174	0	None	-1	2	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	328	3	1	4	3.2	COc1cc2c3c(c1OC)N(c1ccc(F)cc1)CC3CNCC2	10.1016/s0960-894x(98)00138-3
		44415845	86788	0	None	34	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	511	3	1	7	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3-n3ccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212844	86788	0	None	34	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	511	3	1	7	4.6	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccccc3-n3ccnc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		11515697	185011	0	None	-7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL458397	185011	0	None	-7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL465054	185011	0	None	-7	3	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	343	1	2	3	4.5	CN1CCc2cc(-c3ccccc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		86767093	136201	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
		CHEMBL3671280	136201	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	330	3	1	4	4.7	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1c(C)cnnc1C	nan
		10574176	16734	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	420	5	1	3	5.3	CN(C)c1ccc(CCN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		CHEMBL114726	16734	0	None	-	1	Rat	7.1	pKi	=	7.1	Binding	Affinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membraneAffinity for Dopamine receptor D1 binding measured by competition against [3H]-SCH- 23390 to rat striatal membrane	ChEMBL	420	5	1	3	5.3	CN(C)c1ccc(CCN2CCc3cc(Cl)c(O)cc3C(c3ccccc3)C2)cc1	10.1021/jm960143p
		44320026	212878	0	None	3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		CHEMBL85689	212878	0	None	3	2	Rat	7.1	pKi	=	7.1	Binding	Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1	ChEMBL	305	2	3	4	3.4	NC[C@@H]1OC(C2CCCCCCC2)Cc2c1ccc(O)c2O	10.1021/jm00112a034
		117774323	139198	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.9	Cc1cc(Oc2ncc(Cl)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697561	139198	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	3	1	5	3.9	Cc1cc(Oc2ncc(Cl)cc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		10643780	126173	0	None	-97	4	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)[nH]c2c1	10.1021/jm0009989
		CHEMBL344602	126173	0	None	-97	4	Bovine	6.1	pKi	=	6.1	Binding	Binding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligandBinding affinity against Dopamine receptor D1 from bovine striatal membranes using [3H]SCH-23390 as radioligand	ChEMBL	384	3	1	3	4.7	N#Cc1ccc2cc(CN3CCN(c4ccc(Cl)c(Cl)c4)CC3)[nH]c2c1	10.1021/jm0009989
		10276451	207064	37	None	-3388	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
		CHEMBL2112910	207064	37	None	-3388	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
		CHEMBL59725	207064	37	None	-3388	9	Human	5.1	pKi	=	5.1	Binding	Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.Binding affinity for porcine Dopamine receptor D1 by [3H]-SCH- 23390 displacement.	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1021/jm025558r
		10276451	207064	37	None	-9120	9	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
		CHEMBL2112910	207064	37	None	-9120	9	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
		CHEMBL59725	207064	37	None	-9120	9	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390Binding affinity towards D1 receptor from porcine striatal membranes using [3H]-SCH- 23390	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2004.05.052
		10276451	207064	37	None	-9120	9	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
		CHEMBL2112910	207064	37	None	-9120	9	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
		CHEMBL59725	207064	37	None	-9120	9	Pig	5.1	pKi	=	5.1	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	461	7	1	4	5.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2s1	10.1016/j.bmcl.2005.07.037
		137632607	163118	0	None	-2344	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	305	3	2	5	1.6	CCCN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1	10.1016/j.bmc.2017.08.037
		CHEMBL4065797	163118	0	None	-2344	5	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranesDisplacement of [3H]SCH23390 from human D1R expressed in HEK293T cell membranes	ChEMBL	305	3	2	5	1.6	CCCN1CCCN(c2ccc(O)c3c2OCC(=O)N3)CC1	10.1016/j.bmc.2017.08.037
		44278298	105940	0	None	-2884	3	Rat	4.1	pKi	=	4.1	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	348	4	0	2	4.3	O=C(c1cccc(CN2CCC(c3ccccc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
		CHEMBL281214	105940	0	None	-2884	3	Rat	4.1	pKi	=	4.1	Binding	In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390In vitro binding affinity against Dopamine receptor D1 of rat striatum using [3H]SCH-23390	ChEMBL	348	4	0	2	4.3	O=C(c1cccc(CN2CCC(c3ccccc3)C2)c1)N1CCCCC1	10.1016/s0960-894x(99)00201-2
		44304652	207101	0	None	-28	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL59749	207101	0	None	-28	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	363	7	1	4	4.4	c1ccc(CN2CC[C@@H](CNCc3csc(-c4ccccc4)n3)C2)cc1	10.1016/s0960-894x(00)00405-4
		44415622	145381	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	591	4	1	5	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc(F)cc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		CHEMBL377564	145381	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	591	4	1	5	7.0	O=C(NN1c2ccc(Cl)cc2N=C(N2CCN(Cc3ccc(F)cc3F)CC2)c2ccccc21)c1ccccc1Cl	10.1016/j.bmcl.2006.06.034
		228	7233	28	None	-30	23	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		33	7233	28	None	-30	23	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		6005	7233	28	None	-30	23	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		CHEMBL53	7233	28	None	-30	23	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		DB00714	7233	28	None	-30	23	Rat	6.1	pKi	=	6.1	Binding	In vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenateIn vitro binding affinity towards Dopamine receptor D1 by displacing [125I]FISCH radioligand in rat striatal homogenate	ChEMBL	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	10.1021/jm00127a005
		180	7189	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		200	7189	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		2160	7189	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		CHEMBL629	7189	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		DB00321	7189	56	None	-109	40	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	10.1016/j.bmcl.2008.09.012
		135398737	7745	93	None	-44	90	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		38	7745	93	None	-44	90	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		722	7745	93	None	-44	90	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		CHEMBL42	7745	93	None	-44	90	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		DB00363	7745	93	None	-44	90	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	10.1016/j.bmcl.2008.09.012
		44276652	106270	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
		CHEMBL283247	106270	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cellsBinding affinity to Dopamine receptor D1 by using radioligand [125I]SCH-23982 in HEK cells	ChEMBL	324	3	3	4	3.4	CCCCc1cnc2c(c1)[C@@H]1c3cc(O)c(O)cc3CC[C@H]1NC2	10.1016/s0960-894x(99)00214-0
		127045855	146442	0	None	-9	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		CHEMBL3797876	146442	0	None	-9	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	319	8	4	6	1.8	COc1ccccc1OCCNC[C@H](O)c1ccc(O)c(O)c1	10.1016/j.bmc.2016.04.028
		44381276	65502	0	None	-2	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
		CHEMBL168541	65502	0	None	-2	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	348	4	1	4	2.1	O=C1C[C@@H](CN2CCN(c3ccccc3)CC2)N=C(c2ccccc2)N1	10.1016/s0960-894x(03)00004-0
		44304644	210030	0	None	-8	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	454	8	2	4	4.5	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)c[nH]1	10.1016/s0960-894x(00)00405-4
		CHEMBL64566	210030	0	None	-8	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	454	8	2	4	4.5	COc1ccc(Br)cc1-c1nc(CNC[C@@H]2CCN(Cc3ccccc3)C2)c[nH]1	10.1016/s0960-894x(00)00405-4
		154703922	183068	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4590211	183068	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4595146	183068	1	None	-446	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	482	11	1	2	7.2	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		154703824	183405	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4456007	183405	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		CHEMBL4597876	183405	1	None	-346	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	471	11	2	2	6.5	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1Cl	10.1021/acs.jmedchem.9b01835
		181743	185351	5	None	-446	22	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH233930 from human dopamine D1 receptorDisplacement of [3H]SCH233930 from human dopamine D1 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		CHEMBL467094	185351	5	None	-446	22	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH233930 from human dopamine D1 receptorDisplacement of [3H]SCH233930 from human dopamine D1 receptor	ChEMBL	339	2	0	5	3.2	COc1cc2c3c(c1OC)-c1cc4c(cc1CC3N(C)CC2)OCO4	10.1016/j.bmcl.2009.11.053
		242	7258	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		34	7258	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		60795	7258	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		CHEMBL1112	7258	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		DB01238	7258	124	None	-281	51	Human	6.1	pKi	=	6.1	Binding	Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.Radioligand Binding Assay: Membranes prepared as above were resuspended to 1 ug protein/ul (measured by Bradford assay using BSA as standard), and 50 ul were added to each well of a polypropylene 96-well plate containing (per well): 50 ul of buffer (20 mM HEPES, 10 mM MgCl2, 1 mM EDTA, 1 mM EGTA, 100 mM N-methyl-D-gluconate, pH 7.4), 50 ul of 1.5 nM [3H]N-methylspiperone (final concentration 0.3 nM) and reference or D2 test ligand at various concentrations ranging from 50 uM to 50 uM (final concentrations ranging from 10 uM to 10 uM, triplicate determinations for each concentration of D2 test ligand). After a 1.5-hr incubation in the dark at room temperature, the reactions were harvested onto 0.3% PEI-soaked Filtermax GF/A filters (Wallac) and washed three times with ice-cold 50 mM Tris, pH 7.4 using a Perkin-Elmer Filtermate 96-well harvester. The filters were subsequently dried, placed on a hot plate (100° C.), and Melitilex-A (Wallac) scintillant was applied.	ChEMBL	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	nan
		44304621	210198	0	None	-74	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		CHEMBL65641	210198	0	None	-74	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	469	9	1	5	5.1	COc1ccc(Br)cc1-c1nc(CNCC[C@@H]2CCN(Cc3ccccc3)C2)co1	10.1016/s0960-894x(00)00405-4
		6101909	107713	1	None	1	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
		CHEMBL294012	107713	1	None	1	3	Human	6.1	pKi	=	6.1	Binding	Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1Binding affinity to displace [3H]-SCH- 23390 against Dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00170a025
		6101909	107713	1	None	-1	3	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
		CHEMBL294012	107713	1	None	-1	3	Rat	6.1	pKi	=	6.1	Binding	Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat striatal homogenate dopamine receptor D1	ChEMBL	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2[C@H]2c3ccccc3CC[C@H]21	10.1021/jm00128a038
		44455426	161928	0	None	-12	12	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		CHEMBL402143	161928	0	None	-12	12	Human	6.1	pKi	=	6.1	Binding	Inhibition of human cloned dopamine D1 receptor by competitive binding experimentInhibition of human cloned dopamine D1 receptor by competitive binding experiment	ChEMBL	405	9	1	4	4.2	COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1	10.1016/j.bmc.2009.03.021
		44415629	86805	0	None	338	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccsc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL212896	86805	0	None	338	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	451	2	1	6	4.5	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3ccsc3)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		10107367	109211	1	None	-7	4	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		CHEMBL303993	109211	1	None	-7	4	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	273	1	1	2	3.6	CN1CCc2cc(Cl)c(O)cc2[C@@H]1c1ccccc1	10.1021/jm00051a008
		44385980	68158	0	None	3	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	268	1	1	2	3.2	Fc1ccc(N2CC3CNCCc4cccc2c43)cc1	10.1016/s0960-894x(98)00138-3
		CHEMBL176990	68158	0	None	3	2	Rat	8.0	pKi	=	8.0	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	ChEMBL	268	1	1	2	3.2	Fc1ccc(N2CC3CNCCc4cccc2c43)cc1	10.1016/s0960-894x(98)00138-3
		11558247	82197	0	None	2	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
		CHEMBL204098	82197	0	None	2	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	282	0	2	3	2.6	CN1CCc2ccccc2Cc2cc(N)c(O)cc2CC1	10.1021/jm051237e
		86764211	139224	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697587	139224	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	357	3	1	5	3.2	Cc1cc(Oc2ncccc2Cl)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		11573806	82191	0	None	-7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
		CHEMBL204065	82191	0	None	-7	4	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH 23390 from D1 dopamine receptorDisplacement of [3H]SCH 23390 from D1 dopamine receptor	ChEMBL	311	2	0	3	3.3	COc1ccc2c(c1)CCN(C)CCc1cc(OC)ccc1C2	10.1021/jm051237e
		2865	10915	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		59	10915	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		60854	10915	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		CHEMBL708	10915	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		DB00246	10915	73	None	-114	53	Human	8.0	pKi	=	8.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	10.1021/jm0002432
		1353	8692	93	None	-30	85	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		3559	8692	93	None	-30	85	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		86	8692	93	None	-30	85	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		CHEMBL54	8692	93	None	-30	85	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		DB00502	8692	93	None	-30	85	Pig	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/j.bmcl.2014.06.079
		10830233	209632	0	None	8	2	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	329	0	2	1	4.3	CN1CCc2c([nH]c3ccccc23)Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
		CHEMBL62529	209632	0	None	8	2	Rat	8.0	pKi	=	8.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	329	0	2	1	4.3	CN1CCc2c([nH]c3ccccc23)Cc2[nH]c3ccccc3c2CC1	10.1021/jm9911478
		117774170	139213	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	385	3	1	4	4.3	Cc1cc(Oc2ncccc2Br)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697576	139213	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	385	3	1	4	4.3	Cc1cc(Oc2ncccc2Br)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		134137323	149745	0	None	33	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	4	2	5	4.7	CCC(C)Oc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		CHEMBL3894329	149745	0	None	33	3	Human	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting methodDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEKT cell membranes after 90 mins by microbeta scintillation counting method	ChEMBL	447	4	2	5	4.7	CCC(C)Oc1c(O)cc(Br)c2c1CN1CCc3cc(OC)c(O)cc3[C@@H]1C2	10.1016/j.ejmech.2016.09.036
		74223724	136195	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3671274	136195	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	2	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		74223777	136213	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	350	3	1	4	5.1	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1Cl	nan
		CHEMBL3671291	136213	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	350	3	1	4	5.1	Cc1ncnc(C)c1-c1ccc(Oc2nccc3[nH]ccc23)cc1Cl	nan
		44393403	71852	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
		CHEMBL182379	71852	0	None	-891	6	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	533	8	1	5	4.4	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3cc(I)ccc3o2)CC1	10.1021/jm900095y
		137655735	165771	0	None	-1230	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	8	2	8	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4096353	165771	0	None	-1230	5	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	436	8	2	8	2.7	COc1ccccc1N1CCN(CCCC(=O)Nc2ccn3ncc(/C=N\O)c3c2)CC1	10.1021/acs.jmedchem.6b01857
		52943802	24390	0	None	-199	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	363	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		CHEMBL1258270	24390	0	None	-199	5	Pig	5.1	pKi	=	5.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	363	6	0	2	5.8	Cc1ccc(C)c(C(=O)CCCN2CCC(c3cc(C)ccc3C)CC2)c1	10.1021/jm100899z
		44319368	112841	0	None	-7	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
		CHEMBL313320	112841	0	None	-7	4	Bovine	5.1	pKi	=	5.1	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	429	5	0	5	3.4	COc1ccc(Br)cc1C1=N[C@@H](CN2CCN(c3ccccc3)CC2)CO1	10.1016/s0960-894x(01)00484-x
		10807793	209758	1	None	7	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	350	2	1	3	3.8	COc1cc2c(cc1OC)Cc1[nH]c3ccccc3c1CCN(C)CC2	10.1021/jm9911478
		CHEMBL63063	209758	1	None	7	2	Rat	7.0	pKi	=	7.0	Binding	Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390Binding affinity against Dopamine receptor D1 of rat striatal receptor using [3H]SCH-23390	ChEMBL	350	2	1	3	3.8	COc1cc2c(cc1OC)Cc1[nH]c3ccccc3c1CCN(C)CC2	10.1021/jm9911478
		164627027	193206	0	None	-45	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	466	5	3	4	4.3	O=C(NCc1ccccc1CN1CCc2cc(O)c(O)cc2C1)c1cccc(Br)c1	10.1016/j.bmcl.2021.128047
		CHEMBL4876260	193206	0	None	-45	4	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)Displacement of [3H]SCH23390 from dopamine D1 receptor (unknown origin)	ChEMBL	466	5	3	4	4.3	O=C(NCc1ccccc1CN1CCc2cc(O)c(O)cc2C1)c1cccc(Br)c1	10.1016/j.bmcl.2021.128047
		44403224	78690	0	None	-102	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(F)n1	10.1016/j.bmcl.2005.07.037
		CHEMBL197195	78690	0	None	-102	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	424	7	1	4	3.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cccc(F)n1	10.1016/j.bmcl.2005.07.037
		44436605	155842	0	None	-2951	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		CHEMBL394292	155842	0	None	-2951	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranesDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in porcine striatal membranes	ChEMBL	429	7	1	3	4.3	C#Cc1ccc(C(=O)NCCCCN2CCN(c3cccc(Cl)c3Cl)CC2)cc1	10.1016/j.bmc.2007.08.038
		53318564	65369	0	None	-8	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	646	14	0	7	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCN(CCCN2CCN(c4ccccc4OC)CC2)S(C)(=O)=O)c1-3	10.1016/j.bmc.2011.01.053
		CHEMBL1684129	65369	0	None	-8	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counterDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in human HEK293 cells by liquid scintillation counter	ChEMBL	646	14	0	7	5.5	CCCN1CCc2cccc3c2C1Cc1cccc(OCCCN(CCCN2CCN(c4ccccc4OC)CC2)S(C)(=O)=O)c1-3	10.1016/j.bmc.2011.01.053
		57390119	76078	0	None	-218	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	969	33	2	14	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		CHEMBL1928127	76078	0	None	-218	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from pig D1 receptor in striatal membraneDisplacement of [3H]SCH23390 from pig D1 receptor in striatal membrane	ChEMBL	969	33	2	14	5.4	COc1ccccc1N1CCN(CCCNC(=O)c2ccc(COCCOCCOCCOCCOCCOCc3ccc(C(=O)NCCCN4CCN(c5ccccc5OC)CC4)cc3)cc2)CC1	10.1016/j.bmc.2011.10.063
		44381286	127145	0	None	-4	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
		CHEMBL353220	127145	0	None	-4	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390In vitro Binding affinity towards dopamine D1 receptor using bovine striatal membrane preparations and antagonist [3H]-SCH- 23390	ChEMBL	442	5	1	5	3.4	COc1ccc(Br)cc1C1=NCC[C@@H](CN2CCN(c3ccccc3)CC2)N1	10.1016/s0960-894x(03)00004-0
		118711263	120735	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1ccccc1-c1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
		CHEMBL3325914	120735	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cell membranes by liquid scintillation counting based competition binding assay	ChEMBL	343	2	1	2	5.0	Cc1ccccc1-c1cc2c(cc1O)C(c1ccccc1)CN(C)CC2	10.1016/j.ejmech.2014.07.059
		10432606	211293	0	None	-11	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	426	7	0	4	4.0	O=C(CCCN1CCN(CC2CC(=O)c3ccc(F)cc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
		CHEMBL72649	211293	0	None	-11	2	Rat	6.0	pKi	=	6.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the dopamine receptor D1	ChEMBL	426	7	0	4	4.0	O=C(CCCN1CCN(CC2CC(=O)c3ccc(F)cc3C2)CC1)c1ccc(F)cc1	10.1021/jm00111a046
		10402195	48300	1	None	1	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3Oc3ccccc32)CC1	10.1021/jm00030a011
		CHEMBL149108	48300	1	None	1	2	Rat	5.0	pKi	=	5.0	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	ChEMBL	294	0	0	5	2.5	CN1CCN(C2=Nc3cccnc3Oc3ccccc32)CC1	10.1021/jm00030a011
		6603798	106956	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL1613539	106956	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		CHEMBL288096	106956	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Binding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligandBinding affinity at rat striatal Dopamine receptor D1 using [3H]- SCH-23390 radioligand	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm00168a040
		117773861	139194	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2ncc(Cl)cc2C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		CHEMBL3697557	139194	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	371	3	1	5	3.5	Cc1cc(Oc2ncc(Cl)cc2C)ccc1-c1c(C)c(=O)[nH]c(=O)n1C	nan
		44403213	78562	4	None	-1737	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	423	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
		CHEMBL196744	78562	4	None	-1737	5	Pig	6.0	pKi	=	6.0	Binding	Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand Binding affinity towards Dopamine receptor D1 using porcine striatal membrane and [3H]-SCH- 23390 as radioligand	ChEMBL	423	7	1	3	4.5	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1ccc(F)cc1	10.1016/j.bmcl.2005.07.037
		54581964	68382	0	None	-3162	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	489	8	0	5	5.4	COc1ccccc1N1CCN(CCCCN2CCCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		CHEMBL1771111	68382	0	None	-3162	5	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH-23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	489	8	0	5	5.4	COc1ccccc1N1CCN(CCCCN2CCCc3cc(-c4cccs4)ccc3C2=O)CC1	10.1016/j.bmcl.2010.12.083
		6603798	106956	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL1613539	106956	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		CHEMBL288096	106956	5	None	-17378	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	311	2	3	4	3.3	CCCN1CCc2cc(O)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1021/jm060959i
		137659303	166083	0	None	-154	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		CHEMBL4099711	166083	0	None	-154	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysisDisplacement of [3H]SCH23390 from human Dopamine D1 receptor expressed in HEK293T cell membranes after 2 hrs by scintillation counting analysis	ChEMBL	410	9	1	7	2.8	COc1ccccc1N1CCN(CCCCOc2ccn3nc(CO)cc3c2)CC1	10.1021/acs.jmedchem.6b01857
		118709163	120186	0	None	-338	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	888	21	0	8	11.3	O=C(CCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318835	120186	0	None	-338	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	888	21	0	8	11.3	O=C(CCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		12050196	209897	6	None	-15	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	349	5	0	4	4.1	c1ccc(CN2CCN(Cc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		CHEMBL64043	209897	6	None	-15	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	ChEMBL	349	5	0	4	4.1	c1ccc(CN2CCN(Cc3csc(-c4ccccc4)n3)CC2)cc1	10.1016/s0960-894x(00)00405-4
		71462090	91368	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
		CHEMBL2158640	91368	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
		CHEMBL2221044	91368	0	None	-831	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation countingDisplacement of [3H]-SCH-23390 from human dopamine D1 receptor expressed in HEK293 cells after 30 mins by scintillation counting	ChEMBL	353	3	3	4	4.1	CCCN1C[C@H](c2ccc(O)cc2)C[C@@H]2c3cc(O)c(O)cc3CC[C@H]21	10.1016/j.bmc.2012.08.058
		24949535	188338	0	None	-1122	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
		CHEMBL476722	188338	0	None	-1122	3	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatumDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat brain striatum	ChEMBL	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	10.1021/jm800176x
		177511	108319	23	None	-14	2	Rat	5.0	pKi	=	5.0	Binding	The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.	ChEMBL	255	2	3	3	2.5	Oc1cc2c(cc1O)C(Cc1ccccc1)NCC2	10.1016/s0960-894x(00)00326-7
		CHEMBL298285	108319	23	None	-14	2	Rat	5.0	pKi	=	5.0	Binding	The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.The compound has been evaluated for its binding affinity towards Dopamine receptor D1 by displacing the radioligand [3H]SCH-23390 (1.5 nM) in rat striatal synaptosomes.	ChEMBL	255	2	3	3	2.5	Oc1cc2c(cc1O)C(Cc1ccccc1)NCC2	10.1016/s0960-894x(00)00326-7
		156013773	184052	0	None	-9	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	280	1	0	3	3.3	CN1CCc2cccc3c2C1Cc1ccc([N+](=O)[O-])cc1-3	10.1016/j.bmcl.2020.127053
		CHEMBL4636242	184052	0	None	-9	2	Human	6.0	pKi	=	6.0	Binding	Binding affinity to human D1 receptorBinding affinity to human D1 receptor	ChEMBL	280	1	0	3	3.3	CN1CCc2cccc3c2C1Cc1ccc([N+](=O)[O-])cc1-3	10.1016/j.bmcl.2020.127053
		1353	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		3559	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		86	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		CHEMBL54	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		DB00502	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membraneDisplacement of [3H]SCH 23390 from pig dopamine D1 receptor in striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2009919
		1353	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		3559	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		86	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		CHEMBL54	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		DB00502	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm2004859
		74223773	136202	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)nc[n+]([O-])c1C	nan
		CHEMBL3671281	136202	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	347	3	1	5	3.4	Cc1cc(Oc2nccc3n[nH]cc23)ccc1-c1c(C)nc[n+]([O-])c1C	nan
		154725276	183069	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4456964	183069	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595147	183069	1	None	-34	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	478	12	1	3	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(Cl)ccc1OC	10.1021/acs.jmedchem.9b01835
		25071692	118566	0	None	-2187	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		CHEMBL3287405	118566	0	None	-2187	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	443	7	0	6	4.5	N#Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		118709169	120193	0	None	-6	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1029	31	0	8	15.2	O=C(CCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		CHEMBL3318841	120193	0	None	-6	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assayDisplacement of [3H]SCH23390 from porcine striatal membranes D1 receptor by competitive binding assay	ChEMBL	1029	31	0	8	15.2	O=C(CCCCCCCCCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	10.1016/j.bmcl.2014.06.079
		44372009	55613	0	None	-123	4	Bovine	6.0	pKi	=	6.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	402	4	0	4	5.0	Clc1ccc(N2CCN(Cc3cnn4c(-c5ccccc5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		CHEMBL155913	55613	0	None	-123	4	Bovine	6.0	pKi	=	6.0	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	402	4	0	4	5.0	Clc1ccc(N2CCN(Cc3cnn4c(-c5ccccc5)cccc34)CC2)cc1	10.1016/s0960-894x(01)00814-9
		42626103	63027	0	None	-2137	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	442	6	2	3	4.6	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
		CHEMBL1627323	63027	0	None	-2137	4	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	442	6	2	3	4.6	O=C(NC/C=C/CN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2[nH]1	10.1021/jm900095y
		44241577	20786	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL1197140	20786	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		CHEMBL560721	20786	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in Ltk deficient fibroblast cells by liquid scintillation counting	ChEMBL	387	3	3	4	5.0	CCCN1CCc2cc(-c3ccc(O)cc3)cc3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2009.04.047
		117773063	139221	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	4	1	5	4.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		CHEMBL3697584	139221	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.Competition Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor.D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium.	ChEMBL	391	4	1	5	4.4	Cc1cc(Oc2ncccc2OC(F)(F)F)ccc1-c1c(C)n[nH]c(=O)c1C	nan
		154725001	183426	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4525624	183426	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4598002	183426	1	None	-60	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	2	6.5	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		44344506	20600	0	None	-8	2	Rat	5.0	pKi	=	5.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	327	1	1	2	4.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(-c2ccccc2)c(O)c1-3	10.1021/jm960188q
		CHEMBL119577	20600	0	None	-8	2	Rat	5.0	pKi	=	5.0	Binding	In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.In vitro affinity at Dopamine receptor D1 of rat striatum by [3H]SCH-23390 displacement.	ChEMBL	327	1	1	2	4.8	CN1CCc2cccc3c2[C@H]1Cc1ccc(-c2ccccc2)c(O)c1-3	10.1021/jm960188q
		CHEMBL4802048	220840	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CC[C@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
		25139479	191096	0	None	-1071	4	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
		CHEMBL484202	191096	0	None	-1071	4	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from D1 receptor in pig striatal membraneDisplacement of [3H]SCH23390 from D1 receptor in pig striatal membrane	ChEMBL	438	10	0	4	6.2	C#CC1=CCC(N(CCC)CCCCn2cc(-c3ccc(-c4ccccc4)cc3)nn2)CC1	10.1021/jm800895v
		45483655	204894	0	None	-138	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7ccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)cc7)nn6)cc5)cc4)nn3)cc2)CC1	10.1021/jm901120h
		CHEMBL574534	204894	0	None	-138	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	1047	23	2	14	8.6	COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(-c3cn(Cc4ccc(-c5ccc(Cn6cc(-c7ccc(C(=O)NCCCCN8CCN(c9ccccc9OC)CC8)cc7)nn6)cc5)cc4)nn3)cc2)CC1	10.1021/jm901120h
		71110301	98973	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL2425371	98973	0	None	-13	2	Rat	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysisDisplacement of [3H]-SCH 23390 from dopamine D1 receptor in rat striatal membranes after 1 hr by liquid scintillation counting analysis	ChEMBL	297	1	2	4	2.8	COc1ccc2c(c1)CC1c3cc(O)c(O)cc3CCN1C2	10.1016/j.ejmech.2013.07.036
		CHEMBL4802048	220840	0	None	-	1	Human	5.0	pKi	=	5.0	Binding	GPCRScan assay: inhibition of D1GPCRScan assay: inhibition of D1	ChEMBL		None	None	None		CC[C@H](Nc1c(C#N)c(-c2ccc(-c3cccc(C)c3F)cc2)nc2cnccc12)C(=O)O	10.6019/CHEMBL4800729
		2726	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		621	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		83	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		CHEMBL71	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		DB00477	7706	68	None	-36	72	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	ChEMBL	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	10.1016/j.bmcl.2008.09.012
		127047859	146829	0	None	-338	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	476	12	3	6	4.1	COc1cc(CCNCCc2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		CHEMBL3800341	146829	0	None	-338	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsDisplacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cells	ChEMBL	476	12	3	6	4.1	COc1cc(CCNCCc2ccc(O)c3c2OCC(=O)N3)ccc1OCCCc1ccccc1	10.1016/j.bmc.2016.04.028
		45481877	204908	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	10	2	10	3.6	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5ncccn5)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
		CHEMBL574627	204908	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation countingDisplacement of [3H]SCH23390 from dopamine D1 receptor expressed in HEK293 cells by liquid scintillation counting	ChEMBL	582	10	2	10	3.6	Cc1cccc(C2CN(CCCc3cn(CCCN4CCN(c5ncccn5)CC4)nn3)CCc3cc(O)c(O)cc32)c1	10.1016/j.bmc.2009.06.019
		3082625	201507	8	None	-199	4	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2007.05.057
		CHEMBL53510	201507	8	None	-199	4	Rat	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH-23390 from rat dopamine D1 receptorDisplacement of [3H]SCH-23390 from rat dopamine D1 receptor	ChEMBL	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1[C@@H](C2)N(C)CC3	10.1016/j.bmcl.2007.05.057
		154705128	183070	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4454872	183070	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4595148	183070	1	None	-67	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	462	12	1	3	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		100	10577	58	None	-47	54	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		2637	10577	58	None	-47	54	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		5452	10577	58	None	-47	54	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		CHEMBL479	10577	58	None	-47	54	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		DB00679	10577	58	None	-47	54	Human	7.0	pKi	=	7.0	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	nan
		86767094	136204	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cncc2nccn12	nan
		CHEMBL3671283	136204	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.Receptor Binding Assay: The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists, Molecular Pharmacology 68(4):1039-1048 (2005). This radioligand binding assay used [3H]-SCH23390, a radiolabeled D1 ligand, to evaluate the ability of a test compound to compete with the radioligand when binding to a D1 receptor. D1 binding assays were performed using over-expressing LTK human cell lines. To determine basic assay parameters, ligand concentrations were determined from saturation binding studies where the Kd for [3H]-SCH23390 was found to be 1.3 nM. From tissue concentration curve studies, the optimal amount of tissue was determined to be 1.75 mg/mL per 96 well plate using 0.5 nM of [3H]-SCH23390. These ligand and tissue concentrations were used in time course studies to determine linearity and equilibrium condition.	ChEMBL	341	3	1	5	4.4	Cc1cc(Oc2nccc3[nH]ccc23)ccc1-c1cncc2nccn12	nan
		1353	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		3559	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		86	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		CHEMBL54	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		DB00502	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1Compound was evaluated for its affinity (pKi) to inhibit [3H]SCH-23390 binding to the Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00111a046
		1353	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		3559	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		86	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		CHEMBL54	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		DB00502	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1Inhibition constant for in vitro inhibition of [3H]-SCH- 23390 binding to striatal membranes Dopamine receptor D1	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1016/0960-894X(95)00076-6
		1353	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		3559	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		86	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		CHEMBL54	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		DB00502	8692	93	None	-74	85	Rat	7.0	pKi	=	7.0	Binding	Inhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membraneInhibition of [3H]-SCH- 23390 binding to dopamine receptor D1 rat striatal membrane	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm00042a009
		10454026	24679	0	None	-3019	8	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
		CHEMBL125916	24679	0	None	-3019	8	Rat	6.0	pKi	=	6.0	Binding	Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.Binding affinity for rat striatum Dopamine receptor D1 by [3H]-SCH- -2339 displacement.	ChEMBL	406	8	2	4	3.5	COc1ccccc1N1CCN(CCCCNC(=O)c2cc3ccccc3[nH]2)CC1	10.1021/jm0211220
		10058098	205386	9	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligandCompound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligand	ChEMBL	179	0	3	3	0.8	Oc1cc2c(cc1O)CCNCC2	10.1021/jm00160a018
		CHEMBL57873	205386	9	None	-	1	Rat	6.0	pKi	=	6.0	Binding	Compound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligandCompound was tested for binding affinity against dDopamine receptor D1 using [3H]fenoldopam as a radioligand	ChEMBL	179	0	3	3	0.8	Oc1cc2c(cc1O)CCNCC2	10.1021/jm00160a018
		11678172	84807	0	None	-2137	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		CHEMBL209876	84807	0	None	-2137	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH 23390 from D1 receptor of porcine striatal membraneDisplacement of [3H]SCH 23390 from D1 receptor of porcine striatal membrane	ChEMBL	531	8	1	4	5.6	COc1c(Cl)cccc1N1CCN(CCCCNC(=O)c2cc3ccc2CCc2ccc(cc2)CC3)CC1	10.1021/jm060138d
		25071384	118558	0	None	-251	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		CHEMBL3287397	118558	0	None	-251	5	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	ChEMBL	446	8	0	6	4.4	O=Cc1cnn2ccc(OCCCCN3CCN(c4cccc(Cl)c4Cl)CC3)cc12	10.1021/jm5004039
		44381118	64343	0	None	-426	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
		CHEMBL166587	64343	0	None	-426	4	Bovine	5.0	pKi	=	5.0	Binding	Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.Binding affinity towards bovine dopamine D1 receptor by [3H]-SCH- 23390 displacement.	ChEMBL	387	7	2	4	3.6	CNc1cc(OC)c(C(=O)NC[C@H]2CCN(Cc3ccccc3)C2)cc1Cl	10.1016/s0960-894x(99)00086-4
		44319102	212920	0	None	-16	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
		CHEMBL86060	212920	0	None	-16	4	Bovine	5.0	pKi	=	5.0	Binding	In vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cellsIn vitro for its ability to displace [3H]- SCH 23390 from Dopamine receptor D1 in bovine striatal membrane expressed in CHO cells	ChEMBL	321	4	0	4	2.7	c1ccc(C2=N[C@@H](CN3CCN(c4ccccc4)CC3)CO2)cc1	10.1016/s0960-894x(01)00484-x
		44582187	188349	0	None	-47	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	8	0	4	3.7	COc1ccccc1N1CCN(CCCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		CHEMBL476808	188349	0	None	-47	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptorDisplacement of [3H]SCH23390 from human dopamine D1 receptor	ChEMBL	407	8	0	4	3.7	COc1ccccc1N1CCN(CCCCCN2CCc3ccccc3C2=O)CC1	10.1016/j.bmcl.2009.01.067
		44323870	118368	0	None	3	4	Rat	7.0	pKi	=	7.0	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		CHEMBL328246	118368	0	None	3	4	Rat	7.0	pKi	=	7.0	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	ChEMBL	364	1	0	2	5.2	CC(C)=C1c2ccc(Cl)cc2C=C(N2CCN(C)CC2)c2ccccc21	10.1021/jm00043a008
		25142456	89181	2	None	-48	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		CHEMBL217299	89181	2	None	-48	9	Human	7.0	pKi	=	7.0	Binding	Binding affinity to human cloned dopamine D1 receptorBinding affinity to human cloned dopamine D1 receptor	ChEMBL	269	0	3	4	2.1	Oc1cc2c(cc1O)C1c3ccccc3CNC1CO2	10.1021/jm0604979
		44415685	86942	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	551	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213466	86942	0	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	551	2	1	5	5.7	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)c3cc(F)c(F)c(F)c3F)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		44415450	146401	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	425	1	1	5	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(C)(C)C)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		CHEMBL379757	146401	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from human dopamine D1 receptor expressed in CHO cells	ChEMBL	425	1	1	5	4.2	CN1CCN(C2=Nc3cc(Cl)ccc3N(NC(=O)C(C)(C)C)c3ccccc32)CC1	10.1016/j.bmcl.2006.06.022
		1353	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		3559	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		86	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		CHEMBL54	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		DB00502	8692	93	None	-30	85	Pig	7.0	pKi	=	7.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	10.1021/jm100899z
		118445551	174094	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
		CHEMBL4294009	174094	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation countingDisplacement of [3H]-SCH23390 from human dopamine D1 receptor expressed in LTK cell membranes after 30 mins by liquid scintillation counting	ChEMBL	327	3	0	5	4.9	c1cc(-c2ccc(Oc3nccc4occc34)cc2)n2ccnc2c1	10.1021/acs.jmedchem.8b01622
		53363201	70629	0	None	-114	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	893	27	0	15	7.0	COc1cc(CN2CCN(C)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		CHEMBL1803054	70629	0	None	-114	4	Pig	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	ChEMBL	893	27	0	15	7.0	COc1cc(CN2CCN(C)CC2)ccc1OCCCc1cn(CCCCCCCCn2cc(CCCOc3ccc(CN4CCN(c5ccccc5OC)CC4)cc3OC)nn2)nn1	10.1021/jm2004859
		71722297	109249	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL2397382	109249	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		CHEMBL3040156	109249	0	None	-57	3	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysisDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by scintillation counting analysis	ChEMBL	297	1	3	4	2.3	CN1CCc2ccc(CO)c3c2[C@H]1Cc1ccc(O)c(O)c1-3	10.1016/j.bmc.2013.05.014
		49782601	24260	0	None	-602	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	487	6	1	3	6.2	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		CHEMBL1257810	24260	0	None	-602	5	Pig	5.0	pKi	=	5.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranesDisplacement of [3H]SCH23390 from dopamine D1 receptor in pig striatal membranes	ChEMBL	487	6	1	3	6.2	O=C(CCCN1CCC(O)(c2ccc(Cl)cc2)CC1)c1cc2ccc1CCc1ccc(cc1)CC2	10.1021/jm100899z
		10561522	42975	0	None	-51	2	Bovine	4.0	pKi	=	4.0	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2c(C)cccc2C)C1	10.1021/jm9708700
		CHEMBL144501	42975	0	None	-51	2	Bovine	4.0	pKi	=	4.0	Binding	Binding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 like from bovine retina membranes measured using [3H]SCH-23390 radioligand	ChEMBL	231	3	0	1	3.9	CCCN1CCCC(c2c(C)cccc2C)C1	10.1021/jm9708700
		154705520	183039	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4452683	183039	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		CHEMBL4594959	183039	1	None	-64	6	Human	6.0	pKi	=	6.0	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	448	11	1	3	5.6	CCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1cc(F)ccc1OC	10.1021/acs.jmedchem.9b01835
		2750	210840	76	None	-5	12	Human	5.0	pKi	=	5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		CHEMBL7002	210840	76	None	-5	12	Human	5.0	pKi	=	5	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	ChEMBL	333	5	1	4	3.9	CC1(COc2ccc(CC3SC(=O)NC3=O)cc2)CCCCC1	nan
		15115519	213986	0	None	-151	2	Human	7.0	pKi	=	7	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	677	12	1	10	6.4	O=C(CCCN1CCC2(CC1)C(=O)N(CCc1ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc1)CN2c1ccccc1)c1ccc(F)cc1	10.1021/jm00115a012
		CHEMBL92649	213986	0	None	-151	2	Human	7.0	pKi	=	7	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	ChEMBL	677	12	1	10	6.4	O=C(CCCN1CCC2(CC1)C(=O)N(CCc1ccc(Nc3ccc([N+](=O)[O-])c4nonc34)cc1)CN2c1ccccc1)c1ccc(F)cc1	10.1021/jm00115a012
		44415605	86890	0	None	11	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		CHEMBL213238	86890	0	None	11	2	Human	7.0	pKi	=	7	Binding	Displacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cellsDisplacement of [3H]SCH 23390 from dopamine D1 receptor expressed in CHO cells	ChEMBL	470	2	1	6	4.3	CN1CCN(C2=Nc3ccccc3N(NC(=O)c3cccc(C#N)c3)c3ccc(Cl)cc32)CC1	10.1016/j.bmcl.2006.06.034
		42625205	63028	0	None	-89	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	405	7	1	5	3.6	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
		CHEMBL1627324	63028	0	None	-89	2	Human	6.0	pKi	=	6	Binding	Displacement of [3H]SCH23390 from D1 receptorDisplacement of [3H]SCH23390 from D1 receptor	ChEMBL	405	7	1	5	3.6	COc1ccccc1N1CCN(C/C=C/CNC(=O)c2cc3ccccc3o2)CC1	10.1021/jm900095y
		3303	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
		5311200	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
		CHEMBL267014	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1Binding affinity was evaluated for the displacement of [3H]-SCH- 23390 against bovine Dopamine receptor D1	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(98)00692-1
		3303	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
		5311200	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
		CHEMBL267014	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23390 from bovine dopamine D1 receptorDisplacement of [3H]SCH23390 from bovine dopamine D1 receptor	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/j.bmc.2009.05.015
		24824066	164159	0	None	-2	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		CHEMBL407818	164159	0	None	-2	4	Pig	5.0	pKi	=	5	Binding	Displacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membraneDisplacement of [3H]SCH23990 from dopamine D1 receptor in pig striatal membrane	ChEMBL	308	3	1	5	2.4	Oc1ccc(N2CCN(Cc3cnn4ccccc34)CC2)cc1	10.1021/jm701375u
		3303	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
		5311200	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
		CHEMBL267014	9024	46	None	-14791	15	Bovine	5.0	pKi	=	5	Binding	In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.In vitro binding affinity at human cloned dopamine receptor D1 stably expressed in CHO cells by [3H]-SCH- 23390 displacement.	ChEMBL	326	3	1	3	3.5	Clc1ccc(cc1)N1CCN(CC1)Cc1c[nH]c2c1cccn2	10.1016/s0960-894x(01)00814-9
		154706703	183011	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4550187	183011	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		CHEMBL4594691	183011	1	None	-17	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	432	11	1	2	6.0	CCCN(CCCCNC(=O)c1ccc2ccccc2c1)CC1CC1c1ccc(F)cc1	10.1021/acs.jmedchem.9b01835
		154725749	183467	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4453478	183467	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		CHEMBL4598388	183467	1	None	-91	5	Human	6.0	pKi	=	6	Binding	Displacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting methodDisplacement of [3H]-SCH23390 from recombinant human D1 receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scintillation counting method	ChEMBL	437	11	2	2	5.8	CCCN(CCCCNC(=O)c1cc2ccccc2[nH]1)CC1CC1c1cccc(Cl)c1	10.1021/acs.jmedchem.9b01835
		240	7731	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	7731	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	7731	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	7731	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	7731	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	7731	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	7731	43	None	-	25	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to dopamine receptor D1Binding affinity to dopamine receptor D1	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		3294	8787	111	None	-	44	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	None	-	44	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	None	-	44	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	None	-	44	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	None	-	44	Mouse	8.2	pIC50	=	8.2	Binding	Binding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligandBinding affinity against Dopamine receptor D1 was determined using [3H]SCH-23390 radioligand	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2601	10552	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	10552	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	10552	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	10552	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	10552	33	None	-	21	Rat	8.2	pIC50	=	8.2	Binding	In vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligandIn vitro binding activity against Dopamine receptor D1 from homogenized rat brain, using [3H]SCH-23390 as the radioligand	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		100	10577	58	None	-16	54	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	None	-16	54	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	None	-16	54	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	None	-16	54	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	None	-16	54	Rat	8.1	pIC50	=	8.1	Binding	Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1Affinity for displacement of [3H]WB-4101 labeled Dopamine receptor D1	Drug Central	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5281878	8441	35	None	-11	16	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	None	-11	16	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	None	-11	16	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	None	-11	16	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	None	-11	16	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	None	-11	16	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	None	-11	16	Rat	8.0	pIC50	=	8.0	Binding	In vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligandIn vivo binding affinity against dopamine (D1) receptor in rat caudate-putamen tissue using [3H]SCH-23390 as radioligand	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1028	7079	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	7079	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	7079	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	7079	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	7079	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	7079	71	None	-91	30	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		1960	9632	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		439260	9632	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		505	9632	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL1437	9632	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00368	9632	67	None	-95	26	Human	8.4	pKd	=	8.4	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	169	2	4	4	0.1	NC[C@@H](c1ccc(c(c1)O)O)O	None
		1153	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		12668023	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026874	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026875	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		3341	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		6603851	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		933	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		939	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		985	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1160786	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1161520	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL588	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		DB00800	8409	58	None	-32	10	Human	8.1	pKd	=	8.1	Binding	Equilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cellsEquilibrium dissociation constant against recombinant Dopamine receptor D1A expressed in COS7 cells	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		2869	10924	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		60	10924	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		60857	10924	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		CHEMBL1185	10924	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		DB00315	10924	89	None	-2	7	Rat	8.0	pKd	=	8.0	Binding	Binding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligandBinding affinity against dopamine receptor D1 in rat striatum using [3H]SCH-23390 as radioligand	Drug Central	287	5	2	3	1.9	CN(CCc1c[nH]c2c1cc(C[C@H]1COC(=O)N1)cc2)C	None
		5018	10322	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
		943	10322	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
		946	10322	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
		CHEMBL13668	10322	13	None	2	10	Human	9.5	pKd	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	2168520
		3036864	209533	19	3H-SCH23390	-2	27	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	209533	19	3H-SCH23390	2	27	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	209533	19	3H-SCH23390	-2	27	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	2	27	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	2	27	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	2	27	Mouse	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Rat	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		None	223163	0	3H-SCH23390	5495	2	Rat	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	329	1	1	3	3.6	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OCC4)O)Cl	None
		None	223161	0	3H-SCH23390	165	2	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	327	1	1	3	4.4	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OC=C4)O)Cl	None
		3036864	209533	19	3H-SCH23390	-2	27	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Rat	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		1242	10385	27	3H-SCH23390	1	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390	1	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390	1	17	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1243	10390	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
		944	10390	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
		CHEMBL324017	10390	34	3H-SCH23390	3	5	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	None
		5281878	8441	35	3H-SCH23390	-4	16	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281878	8441	35	3H-SCH23390	-11	16	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-4	16	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-11	16	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-4	16	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-11	16	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-4	16	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-11	16	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-4	16	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-11	16	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-4	16	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-11	16	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-4	16	Mouse	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-11	16	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3036864	209533	19	3H-SCH23390	-2	27	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Rat	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	209533	19	3H-SCH23390	-2	27	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	209533	19	3H-SCH23390	-2	27	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	209533	19	3H-SCH23390	-2	27	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Rat	9.4	pKi	=	9.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		25058166	222739	0	3H-SCH23390 High	-6	26	Bovine	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-SCH23390 High	-6	26	Bovine	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		3036864	209533	19	3H-SCH23390	-26	27	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-26	27	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-26	27	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-26	27	Bovine	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	209533	19	3H-SCH23390	-3	27	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-3	27	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-3	27	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-3	27	Rhesus macaque	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		5018	10322	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		5018	10322	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	10322	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	10322	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	10322	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	10322	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	10322	13	3H-SCH23390	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	10322	13	UNDEFINED	2	10	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		3036864	209533	19	3H-SCH23390	-2	27	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Rat	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		37459	7533	13	3H-SCH23390	-2	24	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		37459	7533	13	3H-SCH23390	-8	24	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-SCH23390	-2	24	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-SCH23390	-8	24	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-SCH23390	-2	24	Mouse	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-SCH23390	-8	24	Rat	9.0	pKi	=	9.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		133538	10391	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
		8443	10391	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
		CHEMBL574558	10391	24	3H-SCH23390	1	6	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	317	1	2	3	3.7	CN1CCc2c(C(C1)c1cccc(c1)C)cc(c(c2Cl)O)O	None
		3036864	209533	19	3H-SCH23390	-3	27	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-3	27	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-3	27	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-3	27	Rhesus macaque	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		3036864	209533	19	3H-SCH23390	-2	27	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-2	27	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-2	27	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-2	27	Rat	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		1218	10388	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		938	10388	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		CHEMBL353335	10388	30	3H-SCH23390	11	8	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		None	223165	0	3H-SCH23390	436	2	Mouse	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	349	1	2	3	3.3	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)O.Br	None
		277	8083	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-SCH23390	-33	50	Human	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		135398745	9688	112	UNDEFINED	-23	65	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	UNDEFINED	-23	65	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	UNDEFINED	-23	65	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	UNDEFINED	-23	65	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		6603820	102549	19	3H-SCH23390	1	12	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	3H-SCH23390	1	12	Rat	8.0	pKi	=	8	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		1241	106955	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		CHEMBL288090	106955	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		CHEMBL552611	106955	24	3H-SCH23390	-1	8	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		135398745	9688	112	3H-SCH23390	-23	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-23	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-23	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-23	65	Rat	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		100	10577	58	3H-SCH23390	-47	54	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-SCH23390	-47	54	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-SCH23390	-47	54	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-SCH23390	-47	54	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-SCH23390	-47	54	Human	7.0	pKi	=	7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		202	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		60835	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		972	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		CHEMBL1175	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		DB00476	8290	77	UNDEFINED	-9	33	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	297	6	1	3	4.6	CNCC[C@@H](c1cccs1)Oc1cccc2c1cccc2	None
		2	10035	23	3H-SCH23390	-208	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	10035	23	3H-SCH23390	-208	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	10035	23	3H-SCH23390	-208	28	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		121881	10263	27	3H-SCH23390	-48977	15	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		256	10263	27	3H-SCH23390	-48977	15	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		CHEMBL68131	10263	27	3H-SCH23390	-48977	15	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	382	6	1	6	3.4	CCCCN1CCC(CC1)COC(=O)c1cc(Cl)c(c2c1OCCO2)N	None
		46222048	15756	0	UNDEFINED	-4365	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	None
		CHEMBL1098230	15756	0	UNDEFINED	-4365	13	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	260	4	1	2	4.0	CC(C)(C)c1ccc(SCCc2c[nH]cn2)cc1	None
		18922713	105274	0	3H-SCH23390	-12882	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
		CHEMBL276031	105274	0	3H-SCH23390	-12882	9	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	298	6	1	2	4.0	CCCN(CCC)C1Cc2c[nH]c3ccc(C(C)=O)c(c23)C1	None
		24840389	121991	4	3H-SCH23390	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		CHEMBL334529	121991	4	3H-SCH23390	-741	16	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	415	9	0	4	4.6	CCCN(CCC)C1CCc2cc(CS(=O)(=O)c3ccc(OC)cc3)ccc2C1	None
		44591098	183541	0	UNDEFINED	-288	6	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL460402	183541	0	UNDEFINED	-288	6	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	508	9	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)c1ccc(OCCCN2CCCCC2)cc1	None
		12016890	197555	6	3H-SCH23390	-1698	12	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
		CHEMBL5183389	197555	6	3H-SCH23390	-1698	12	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	318	4	1	3	2.6	NC(=O)c1ccc(F)c2c1CC(N(C1CCC1)C1CCC1)CO2	None
		5656	209845	87	UNDEFINED	-25	43	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	UNDEFINED	-25	43	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		54841	209906	52	UNDEFINED	-1	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		CHEMBL641	209906	52	UNDEFINED	-1	30	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	255	6	1	2	3.7	CNCC[C@@H](Oc1ccccc1C)c1ccccc1	None
		None	222771	0	3H-SCH23390	-107	11	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.2	C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl	None
		104911	222798	0	3H-SCH23390	-4168	37	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		3075702	224111	0	3H-SCH23390	-2	37	Human	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	198	3	1	3	1.5	C1CNC1COC2=CN=C(C=C2)Cl	None
		1574	6869	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		218	6869	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		CHEMBL266591	6869	60	3H-SCH23390	-107	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	2	3	2	1.7	Cc1c(CCN)c2c([nH]1)ccc(c2)O	None
		5	6927	72	3H-SCH23390 Low	-23442	53	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	6927	72	3H-SCH23390	-23442	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5	6927	72	3H-SCH23390	-16595	53	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-SCH23390 Low	-23442	53	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-SCH23390	-23442	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-SCH23390	-16595	53	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-SCH23390 Low	-23442	53	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-SCH23390	-23442	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-SCH23390	-16595	53	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-SCH23390 Low	-23442	53	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-SCH23390	-23442	53	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-SCH23390	-16595	53	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		1192	6935	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1794	6935	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		CHEMBL501701	6935	47	3H-dopamine	-162	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	311	2	3	5	0.5	NC(=NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1)N	None
		1220	6975	55	3H-SCH23390	-7943	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		31	6975	55	3H-SCH23390	-7943	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		7	6975	55	3H-SCH23390	-7943	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		CHEMBL56	6975	55	3H-SCH23390	-7943	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	247	5	1	2	3.4	CCCN(C1CCc2c(C1)c(O)ccc2)CCC	None
		3153	7085	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		932	7085	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		CHEMBL26736	7085	28	3H-SCH23390 Low	-39	8	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		179	7188	115	3H-SCH23390	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		179	7188	115	3H-SCH23390	-4365	50	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	3H-SCH23390	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2159	7188	115	3H-SCH23390	-4365	50	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	3H-SCH23390	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		963	7188	115	3H-SCH23390	-4365	50	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	3H-SCH23390	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		CHEMBL243712	7188	115	3H-SCH23390	-4365	50	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	3H-SCH23390	-4365	50	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		DB06288	7188	115	3H-SCH23390	-4365	50	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	369	7	2	6	1.3	CCN1CCCC1CNC(=O)c1cc(c(cc1OC)N)S(=O)(=O)CC	None
		2554	7583	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		489	7583	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		5339	7583	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		CHEMBL108	7583	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		DB00564	7583	119	3H-SCH23390	-48	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	236	0	1	1	3.4	NC(=O)N1c2ccccc2C=Cc2c1cccc2	None
		2147	8183	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		5826	8183	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		841	8183	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		CHEMBL612	8183	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		DB01576	8183	17	3H-SCH23390	-53	7	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	2	1	1	1.6	C[C@@H](Cc1ccccc1)N	None
		3016	8194	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		3364	8194	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		852	8194	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		CHEMBL12	8194	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		DB00829	8194	48	3H-SCH23390	-2454	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	1	0	2	3.2	Clc1ccc2c(c1)C(=NCC(=O)N2C)c1ccccc1	None
		3151	8244	97	3H-SCH23390	-12882	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	8244	97	3H-SCH23390	-12882	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	8244	97	3H-SCH23390	-12882	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	8244	97	3H-SCH23390	-12882	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	8244	97	3H-SCH23390	-12882	26	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		681	8247	72	3H-SCH23390 Low	-23	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		681	8247	72	3H-SCH23390	-97	38	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-SCH23390 Low	-23	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-SCH23390	-97	38	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-SCH23390 Low	-23	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-SCH23390	-97	38	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-SCH23390 Low	-23	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-SCH23390	-97	38	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-SCH23390 Low	-23	38	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-SCH23390	-97	38	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1209	8439	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		203	8439	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		3386	8439	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		CHEMBL41	8439	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		DB00472	8439	75	3H-SCH23390	-1862	32	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	6	1	2	4.4	CNCCC(c1ccccc1)Oc1ccc(cc1)C(F)(F)F	None
		1067	8490	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		119	8490	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		1262	8490	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		5410	8490	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		6992099	8490	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		CHEMBL96	8490	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		DB02530	8490	128	3H-SCH23390	-10	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	103	3	2	2	-0.2	NCCCC(=O)O	None
		119376	8622	48	3H-SCH23390	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		247	8622	48	3H-SCH23390	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		CHEMBL33884	8622	48	3H-SCH23390	-54954	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	1	6	1.6	O=C(c1cn(c2c1cccc2)C)OCC1CCN(CC1)CCNS(=O)(=O)C	None
		1204	8713	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1247	8713	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		1375	8713	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		774	8713	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		CHEMBL90	8713	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		DB05381	8713	119	3H-SCH23390	-1949	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	111	2	2	2	-0.1	NCCc1cnc[nH]1	None
		12575	8769	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		54459	8769	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		CHEMBL10316	8769	30	3H-SCH23390	-6606	17	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	204	1	1	4	0.8	C1CN=C(N1)C2COC3=CC=CC=C3O2	None
		1427	8794	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1427	8794	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	8794	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	8794	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	8794	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	8794	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	8794	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	8794	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	8794	54	3H-dopamine	-977	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	8794	54	3H-SCH23390	-977	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		1310	9095	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		1369	9095	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		33032	9095	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		44272391	9095	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		88747398	9095	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		CHEMBL575060	9095	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		DB00142	9095	110	3H-SCH23390	-43	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	147	4	3	3	-0.7	OC(=O)CC[C@@H](C(=O)O)N	None
		18971832	9196	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		21	9196	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		CHEMBL3186179	9196	0	3H-SCH23390	-1621	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	3	2	2	4.0	CN(C1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C	None
		119192	9259	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
		1582	9259	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
		CHEMBL506981	9259	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
		DB06455	9259	54	3H-SCH23390	-2818	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	586	7	2	7	5.8	COc1cccc(c1c1cc(nn1c1ccnc2c1ccc(c2)Cl)C(=O)NC1(C(=O)O)C2CC3CC1CC(C2)C3)OC	None
		1605	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		1728	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		22267	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		4095	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		4586	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		5458	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		CHEMBL159659	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		CHEMBL651	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		DB00333	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		DB13515	9276	24	3H-dopamine	-3235	10	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	7	0	2	4.3	CCC(=O)C(c1ccccc1)(c1ccccc1)C[C@H](N(C)C)C	None
		134	9292	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-SCH23390	-263	67	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1782	9296	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		241	9296	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		4168	9296	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		CHEMBL86	9296	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		DB01233	9296	84	3H-SCH23390	-676	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	299	7	2	4	2.0	CCN(CCNC(=O)c1cc(Cl)c(cc1OC)N)CC	None
		1830	9368	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		1830	9368	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	9368	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	9368	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	9368	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	9368	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	9368	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	9368	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	9368	44	3H-dopamine	-1778	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	9368	44	3H-SCH23390	-1778	28	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		1638	9501	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		1676	9501	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		1878	9501	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		5284596	9501	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		CHEMBL80	9501	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		DB01183	9501	38	3H-SCH23390	-5495	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	1.3	C=CCN1CC[C@@]23[C@@]4([C@H]1Cc1c3c(O[C@H]2C(=O)CC4)c(cc1)O)O	None
		484	9633	51	3H-SCH23390	-223	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		484	9633	51	3H-SCH23390	-100	35	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	3H-SCH23390	-223	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	3H-SCH23390	-100	35	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	3H-SCH23390	-223	35	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	3H-SCH23390	-100	35	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		15897	9637	0	3H-SCH23390	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		215	9637	0	3H-SCH23390	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		CHEMBL1979333	9637	0	3H-SCH23390	-354	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	203	2	1	1	2.6	CC(Cc1cccc(c1)C(F)(F)F)N	None
		163839	9729	0	3H-SCH23390	-562	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		268	9729	0	3H-SCH23390	-562	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		CHEMBL55171	9729	0	3H-SCH23390	-562	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	391	6	1	4	3.7	Cc1cccc(c1C)N1CCN(CC1)CCCOc1ccc2c(c1)[nH]c(=O)cc2	None
		2136	9869	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		4768	9869	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		7268	9869	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		CHEMBL753	9869	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		DB00925	9869	30	3H-dopamine	-2511	6	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	8	0	2	4.2	ClCCN(C(COc1ccccc1)C)Cc1ccccc1	None
		2142	9870	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2142	9870	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		2142	9870	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		4920903	9870	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		502	9870	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		5775	9870	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		CHEMBL597	9870	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-SCH23390	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-dopamine	-3801	37	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		DB00692	9870	58	3H-SCH23390	-3801	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	281	4	2	4	2.8	Cc1ccc(cc1)N(c1cccc(c1)O)CC1=NCCN1	None
		16362	9899	71	3H-SCH23390	-52480	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	3H-SCH23390	-52480	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	3H-SCH23390	-52480	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	3H-SCH23390	-52480	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	3H-SCH23390	-52480	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2202	9906	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		4850	9906	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		49	9906	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		CHEMBL1371770	9906	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		DB12478	9906	96	3H-SCH23390	-316	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	298	3	0	6	1.5	c1cnc(nc1)N1CCN(CC1)Cc1ccc2c(c1)OCO2	None
		119570	9933	96	3H-SCH23390	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		119570	9933	96	UNDEFINED	-4570	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	3H-SCH23390	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2233	9933	96	UNDEFINED	-4570	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	3H-SCH23390	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		953	9933	96	UNDEFINED	-4570	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	3H-SCH23390	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		CHEMBL301265	9933	96	UNDEFINED	-4570	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	3H-SCH23390	-4570	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		DB00413	9933	96	UNDEFINED	-4570	39	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	211	3	2	4	1.6	CCCN[C@H]1CCc2c(C1)sc(n2)N	None
		2286	9957	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	9957	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	9957	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	9957	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	9957	51	3H-dopamine	-3311	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2303	9961	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		4946	9961	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		564	9961	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		63	9961	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		91536	9961	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL27	9961	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		CHEMBL452861	9961	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		DB00571	9961	68	3H-dopamine	-21877	26	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	O[C@H](COc1cccc2c1cccc2)CNC(C)C	None
		243	9976	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3052762	9976	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		3502	9976	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		CHEMBL117287	9976	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		DB06480	9976	91	3H-SCH23390	-1096	34	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	367	6	2	5	2.1	COCCCN1CCC(CC1)NC(=O)c1cc(Cl)c(c2c1OCC2)N	None
		2	10035	23	3H-SCH23390 Low	-2089	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		2	10035	23	3H-SCH23390	-977	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	10035	23	3H-SCH23390 Low	-2089	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		54562	10035	23	3H-SCH23390	-977	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	10035	23	3H-SCH23390 Low	-2089	28	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		CHEMBL240773	10035	23	3H-SCH23390	-977	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	2	1	2	2.0	CCCN1CCC[C@H]2[C@H]1Cc1cn[nH]c1C2	None
		173	10036	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		5011	10036	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		CHEMBL18772	10036	95	3H-SCH23390	-114	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	213	1	1	3	1.6	N1CCN(CC1)c1ccc2c(n1)cccc2	None
		3033769	10054	61	3H-SCH23390	-2754	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3033769	10054	61	3H-SCH23390	-2754	18	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3299	10054	61	3H-SCH23390	-2754	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		3299	10054	61	3H-SCH23390	-2754	18	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		94	10054	61	3H-SCH23390	-2754	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		94	10054	61	3H-SCH23390	-2754	18	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		CHEMBL8809	10054	61	3H-SCH23390	-2754	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		CHEMBL8809	10054	61	3H-SCH23390	-2754	18	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		DB12518	10054	61	3H-SCH23390	-2754	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		DB12518	10054	61	3H-SCH23390	-2754	18	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	346	5	2	4	2.9	CCN1CCC[C@H]1CNC(=O)c1c(O)c(Cl)cc(c1OC)Cl	None
		2389	10104	118	3H-SCH23390	-346	66	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-346	66	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-346	66	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-346	66	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-346	66	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2402	10143	62	3H-SCH23390	-61	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	10143	62	3H-SCH23390	-61	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	10143	62	3H-SCH23390	-61	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	10143	62	3H-SCH23390	-61	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	10143	62	3H-SCH23390	-61	24	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		183782	10171	20	3H-SCH23390	-2398	14	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		237	10171	20	3H-SCH23390	-2398	14	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL85251	10171	20	3H-SCH23390	-2398	14	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	352	8	1	4	4.4	CCCCN1CCC(CC1)CCC(=O)c1cc(Cl)c(cc1OC)N	None
		128563	10237	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		1666	10237	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		CHEMBL445332	10237	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		DB12327	10237	33	3H-SCH23390	-2398	42	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	432	3	0	8	3.0	COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@@H]1[C@]2(C)C[C@H](OC1=O)c1cocc1	None
		221	10264	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		3277600	10264	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		CHEMBL323356	10264	71	UNDEFINED	-478	14	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	286	2	2	4	3.6	O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C	None
		1577	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1577	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1577	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1577	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	10475	110	3H-SCH23390	-69	20	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	10475	110	3H-SCH23390	-537	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	10475	110	3H-SCH23390	-537	20	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	10475	110	3H-SCH23390	-537	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		1267	10576	49	3H-dopamine	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		3035905	10576	49	3H-dopamine	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		CHEMBL260374	10576	49	3H-dopamine	-4168	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	292	2	2	2	2.8	S=C(N1CCC(CC1)c1cnc[nH]1)NC1CCCCC1	None
		102	10899	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		3659	10899	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		8969	10899	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		CHEMBL15245	10899	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		DB01392	10899	48	3H-SCH23390	-25118	49	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	1	2	4	2.6	COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1	None
		6047	11095	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O	None
		6971033	11095	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O	None
		CHEMBL1009	11095	110	3H-SCH23390	1	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	197	3	4	4	0.1	N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O	None
		19493	18027	65	3H-SCH23390	-2344	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
		CHEMBL1179	18027	65	3H-SCH23390	-2344	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
		CHEMBL1255743	18027	65	3H-SCH23390	-2344	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	133	1	1	1	1.5	N[C@@H]1C[C@H]1c1ccccc1	None
		2662	18156	131	3H-SCH23390	-3	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	18156	131	3H-SCH23390	-3	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		10836	21239	14	3H-SCH23390	-147	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		CHEMBL1201201	21239	14	3H-SCH23390	-147	9	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	3	1	1	1.8	CN[C@@H](C)Cc1ccccc1	None
		5090	22333	106	3H-SCH23390	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		CHEMBL122	22333	106	3H-SCH23390	-1348	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	0	4	2.6	CS(=O)(=O)c1ccc(C2=C(c3ccccc3)C(=O)OC2)cc1	None
		671690	33870	35	3H-SCH23390	-10	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		CHEMBL1365455	33870	35	3H-SCH23390	-10	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	313	2	0	3	3.8	CN1[C@H]2CC[C@@H]1CC(OC(=O)c1cc(Cl)cc(Cl)c1)C2	None
		10297	33885	30	3H-SCH23390	-38	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		CHEMBL136560	33885	30	3H-SCH23390	-38	43	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	C[C@H](N)[C@H](O)c1ccccc1	None
		156391	53574	99	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL1200806	53574	99	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		CHEMBL154	53574	99	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	COc1ccc2cc([C@H](C)C(=O)O)ccc2c1	None
		53321123	65322	0	UNDEFINED	-181	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	0	2	4.2	C#CCOc1cccc2c1-c1cccc3c1C(C2)N(CCC)CC3	None
		CHEMBL1684022	65322	0	UNDEFINED	-181	4	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	0	2	4.2	C#CCOc1cccc2c1-c1cccc3c1C(C2)N(CCC)CC3	None
		10624	77075	19	3H-SCH23390	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		138543650	77075	19	3H-SCH23390	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		CHEMBL194378	77075	19	3H-SCH23390	-776	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	5	3	3	1.7	CN(C)CCc1c[nH]c2cccc(OP(=O)(O)O)c12	None
		14659268	86413	2	UNDEFINED	-134	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	None
		CHEMBL2115032	86413	2	UNDEFINED	-134	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	297	1	2	4	2.9	COc1cc2c3c(c1)-c1c(ccc(O)c1O)CC3N(C)CC2	None
		108107	86719	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		156592250	86719	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL1256878	86719	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		CHEMBL212579	86719	38	3H-dopamine	-15	16	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	3	4	5	0.5	N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)NCc1ccccc1	None
		442108	91411	6	3H-SCH23390	-1	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		CHEMBL222287	91411	6	3H-SCH23390	-1	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	310	2	1	2	3.9	CC[C@H]1C[C@H]2C[C@H]3c4[nH]c5ccc(OC)cc5c4CCN(C2)[C@@H]13	None
		54477	91428	36	3H-SCH23390	-138	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		54477	91428	36	UNDEFINED	-138	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	91428	36	3H-SCH23390	-138	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		CHEMBL22242	91428	36	UNDEFINED	-138	22	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	6	1	4	2.7	CCN1CCC[C@H]1CNC(=O)c1c(OC)ccc(Br)c1OC	None
		21830793	98610	10	3H-8-OH-DPAT	-66069	46	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		CHEMBL2413154	98610	10	3H-8-OH-DPAT	-66069	46	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	373	7	0	8	0.6	COc1ccccc1N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1	None
		2244	101008	100	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		CHEMBL25	101008	100	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	180	2	1	3	1.3	CC(=O)Oc1ccccc1C(=O)O	None
		44448057	101593	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	1	1	2	3.5	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		CHEMBL253529	101593	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	1	1	2	3.5	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		44448062	101623	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
		CHEMBL253737	101623	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	3	0	2	4.2	CCCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
		44448066	101650	0	UNDEFINED	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	None
		CHEMBL253948	101650	0	UNDEFINED	-1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.4	Oc1cc2c3c(c1O)Cc1ccccc1CC3NCC2	None
		44448068	101651	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	4	0	3	5.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(Cc1ccccc1)CC2	None
		CHEMBL253949	101651	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	385	4	0	3	5.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(Cc1ccccc1)CC2	None
		4528	104902	80	3H-SCH23390	-120	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		4528	104902	80	3H-SCH23390	-120	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		CHEMBL273575	104902	80	3H-SCH23390	-120	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		CHEMBL273575	104902	80	3H-SCH23390	-120	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	238	1	1	2	2.8	CN1Cc2c(N)cccc2C(c2ccccc2)C1	None
		104870	105656	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		5374	105656	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		CHEMBL279085	105656	47	3H-SCH23390	-549	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	209	2	1	4	1.3	C=CCN1CCc2nc(N)sc2CC1	None
		3025067	106158	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		65853	106158	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		CHEMBL282614	106158	64	3H-dopamine	-512	15	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	220	1	1	4	0.9	c1cc2c(c(N3CCNCC3)c1)OCCO2	None
		3663	106743	83	3H-SCH23390	-288	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		CHEMBL286494	106743	83	3H-SCH23390	-288	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	504	0	6	8	5.1	Cc1cc(O)c2c(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6c(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c65	None
		127708	119298	7	UNDEFINED	-251	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		CHEMBL329904	119298	7	UNDEFINED	-251	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		3452843	126303	15	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		CHEMBL345686	126303	15	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	516	6	2	4	5.5	Cc1cccc(NC(=O)NC2N=C(c3ccccc3)c3ccccc3N(CC(=O)c3ccccc3C)C2=O)c1	None
		446220	140299	14	3H-SCH23390	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		CHEMBL370805	140299	14	3H-SCH23390	-1778	45	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	3	0	5	1.9	COC(=O)[C@H]1[C@@H](OC(=O)c2ccccc2)C[C@@H]2CC[C@H]1N2C	None
		44208932	147485	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		CHEMBL381689	147485	7	UNDEFINED	-89125	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	475	5	1	3	6.8	Cc1ccc(Cn2nc(C(=O)NC3C4(C)CCC(C4)C3(C)C)cc2-c2ccc(Cl)c(C)c2)cc1	None
		9669	159967	2	3H-dopamine	-3890	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	2	1	2	3.9	CC(C)=CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@@H]1[C@H]2C	None
		CHEMBL397705	159967	2	3H-dopamine	-3890	7	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	285	2	1	2	3.9	CC(C)=CCN1CC[C@@]2(C)c3cc(O)ccc3C[C@@H]1[C@H]2C	None
		44448058	161983	0	UNDEFINED	2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		CHEMBL402517	161983	0	UNDEFINED	2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	3.8	CCCN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		44448065	162259	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		CHEMBL404037	162259	0	UNDEFINED	-2	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	309	2	2	3	3.6	CCCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		44448069	162309	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	337	4	0	3	4.2	CCCN1CCc2cc(OC)c(OC)c3c2C1Cc1ccccc1C3	None
		CHEMBL404241	162309	0	UNDEFINED	1	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	337	4	0	3	4.2	CCCN1CCc2cc(OC)c(OC)c3c2C1Cc1ccccc1C3	None
		1615	174570	24	3H-SCH23390	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		CHEMBL43048	174570	24	3H-SCH23390	-26	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	193	3	1	3	1.6	CNC(C)Cc1ccc2c(c1)OCO2	None
		4595	183494	106	3H-dopamine	-186	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		CHEMBL46	183494	106	3H-dopamine	-186	14	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	293	2	0	4	3.1	Cc1nccn1CC1CCc2c(c3ccccc3n2C)C1=O	None
		44581146	183607	0	UNDEFINED	-354	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.5	COc1cccc2cc3n(c12)CCN(CCCCNC(=O)C1=Cc2ccccc2CN1)C3	None
		CHEMBL461023	183607	0	UNDEFINED	-354	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.5	COc1cccc2cc3n(c12)CCN(CCCCNC(=O)C1=Cc2ccccc2CN1)C3	None
		24949694	189549	0	UNDEFINED	-3981	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	6	0	7	3.4	c1cnc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
		CHEMBL479026	189549	0	UNDEFINED	-3981	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	371	6	0	7	3.4	c1cnc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
		43815	193699	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL1708	193699	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		CHEMBL490	193699	64	3H-SCH23390	-1995	25	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	4	1	4	3.3	Fc1ccc([C@@H]2CCNC[C@H]2COc2ccc3c(c2)OCO3)cc1	None
		11676600	194524	0	UNDEFINED	-1174	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	442	6	0	5	4.4	COc1cccc2cc3n(c12)CCN(CCCCN1CCn2c(cc4ccccc42)C1=O)C3	None
		CHEMBL495573	194524	0	UNDEFINED	-1174	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	442	6	0	5	4.4	COc1cccc2cc3n(c12)CCN(CCCCN1CCn2c(cc4ccccc42)C1=O)C3	None
		11704609	194802	0	UNDEFINED	-2691	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	427	6	0	5	3.6	N#Cc1cccc(N2CCN(CCCCN3CCn4c(cc5ccccc54)C3=O)CC2)c1	None
		CHEMBL497573	194802	0	UNDEFINED	-2691	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	427	6	0	5	3.6	N#Cc1cccc(N2CCN(CCCCN3CCn4c(cc5ccccc54)C3=O)CC2)c1	None
		11596521	194815	0	UNDEFINED	-18620	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	402	7	1	5	3.6	N#Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
		CHEMBL497604	194815	0	UNDEFINED	-18620	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	402	7	1	5	3.6	N#Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
		5280343	195054	124	3H-SCH23390	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL1520590	195054	124	3H-SCH23390	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		CHEMBL50	195054	124	3H-SCH23390	-147	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	302	1	5	7	2.0	O=c1c(O)c(-c2ccc(O)c(O)c2)oc2cc(O)cc(O)c12	None
		44581147	197153	0	UNDEFINED	-1659	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.6	COc1cccc2c1C1CCN(CCCCNC(=O)C3=Cc4ccccc4CN3)CC1=N2	None
		CHEMBL517730	197153	0	UNDEFINED	-1659	4	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	430	7	2	5	3.6	COc1cccc2c1C1CCN(CCCCNC(=O)C3=Cc4ccccc4CN3)CC1=N2	None
		24949388	197307	0	UNDEFINED	-6309	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	6	0	6	3.5	c1ccc(N2CCN(CCCSc3nc4ccccc4o3)CC2)nc1	None
		CHEMBL517962	197307	0	UNDEFINED	-6309	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	354	6	0	6	3.5	c1ccc(N2CCN(CCCSc3nc4ccccc4o3)CC2)nc1	None
		3672	199312	136	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		CHEMBL521	199312	136	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	206	4	1	1	3.1	CC(C)Cc1ccc(C(C)C(=O)O)cc1	None
		54676228	200394	112	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		CHEMBL527	200394	112	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	2	5	1.6	CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O	None
		2771	201796	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		2771	201796	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	201796	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL1200781	201796	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	201796	74	3H-SCH23390	-120	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		CHEMBL549	201796	74	3H-SCH23390	-120	27	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	324	5	0	3	3.8	CN(C)CCCC1(c2ccc(F)cc2)OCc2cc(C#N)ccc21	None
		4495	203314	92	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		CHEMBL56367	203314	92	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	308	5	1	5	2.8	CS(=O)(=O)Nc1ccc([N+](=O)[O-])cc1Oc1ccccc1	None
		45112568	205585	0	UNDEFINED	-229	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	None
		CHEMBL583422	205585	0	UNDEFINED	-229	3	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	465	9	1	7	3.7	CCOC(=O)c1cc2cc(OCCCN3CCN(Cc4ccc5c(c4)OCO5)CC3)ccc2[nH]1	None
		54677470	207330	115	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL1256873	207330	115	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		CHEMBL599	207330	115	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	2	2	6	2.0	Cc1cnc(NC(=O)C2=C(O)c3ccccc3S(=O)(=O)N2C)s1	None
		162265	209053	22	3H-SCH23390	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		4786	209053	22	3H-SCH23390	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		CHEMBL61006	209053	22	3H-SCH23390	-239	44	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	151	2	2	2	1.1	CC(N)C(O)c1ccccc1	None
		3036864	209533	19	3H-SCH23390	-26	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	3H-SCH23390	-26	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	3H-SCH23390	-26	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	3H-SCH23390	-26	27	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		5281600	209804	92	3H-SCH23390	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		CHEMBL63354	209804	92	3H-SCH23390	-275	32	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	538	3	6	10	5.1	O=c1cc(-c2ccc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c2)oc2cc(O)cc(O)c12	None
		5656	209845	87	3H-SCH23390	-25	43	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		CHEMBL637	209845	87	3H-SCH23390	-25	43	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	277	5	1	3	3.0	COc1ccc(C(CN(C)C)C2(O)CCCCC2)cc1	None
		1973	210262	15	3H-SCH23390	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL1394464	210262	15	3H-SCH23390	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		CHEMBL66089	210262	15	3H-SCH23390	-3	36	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	462	3	1	7	3.9	Nc1ncnc2nc(-c3ccc(N4CCOCC4)nc3)cc(-c3cccc(Br)c3)c12	None
		1614	210434	24	3H-SCH23390	-81	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
		CHEMBL6731	210434	24	3H-SCH23390	-81	10	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	2	1	3	1.3	CC(N)Cc1ccc2c(c1)OCO2	None
		202478	211466	20	3H-SCH23390	-52	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
		CHEMBL7393	211466	20	3H-SCH23390	-52	25	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@H](c2cccc(O)c2)C1	None
		3821	211497	17	3H-SCH23390	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		CHEMBL742	211497	17	3H-SCH23390	-1	18	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	237	2	1	2	2.9	CNC1(c2ccccc2Cl)CCCCC1=O	None
		5311189	211620	11	3H-SCH23390	-112	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
		CHEMBL7549	211620	11	3H-SCH23390	-112	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	219	3	1	2	3.0	CCCN1CCC[C@@H](c2cccc(O)c2)C1	None
		4158	212120	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL1722	212120	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		CHEMBL796	212120	21	3H-SCH23390	-141	21	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	233	3	1	3	2.1	COC(=O)C(c1ccccc1)C1CCCCN1	None
		4054	212280	72	3H-SCH23390	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL1699	212280	72	3H-SCH23390	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		CHEMBL807	212280	72	3H-SCH23390	-1	36	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	179	0	1	1	2.7	CC12CC3CC(C)(C1)CC(N)(C3)C2	None
		5324346	212361	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		CHEMBL1409	212361	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		CHEMBL814	212361	59	3H-SCH23390	-1	10	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	318	9	1	4	3.2	COCCCC/C(=N\OCCN)c1ccc(C(F)(F)F)cc1	None
		7108	212537	110	3H-SCH23390	-8	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	199	0	1	2	3.9	c1ccc2c(c1)Nc1ccccc1S2	None
		CHEMBL828	212537	110	3H-SCH23390	-8	5	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	199	0	1	2	3.9	c1ccc2c(c1)Nc1ccccc1S2	None
		119607	212982	113	3H-SCH23390	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		CHEMBL865	212982	113	3H-SCH23390	-97	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	314	3	1	4	3.0	Cc1onc(-c2ccccc2)c1-c1ccc(S(N)(=O)=O)cc1	None
		3337	213146	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		65801	213146	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		66264	213146	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		91452	213146	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		CHEMBL87493	213146	27	3H-SCH23390	-1513	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	231	4	1	1	3.2	CCNC(C)Cc1cccc(C(F)(F)F)c1	None
		444	213445	53	3H-SCH23390	-2089	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		CHEMBL894	213445	53	3H-SCH23390	-2089	18	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	239	3	1	2	3.3	CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1	None
		16231	214288	57	3H-dopamine	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		CHEMBL945	214288	57	3H-dopamine	-7	17	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	229	1	5	6	-1.1	N=C(N)NC(=O)c1nc(Cl)c(N)nc1N	None
		12057539	214820	42	3H-SCH23390	-18620	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		3661	214820	42	3H-SCH23390	-18620	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		CHEMBL9751	214820	42	3H-SCH23390	-18620	21	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	4	1	4	1.9	CN1C2CCC1CC(OC(=O)C(CO)c1ccccc1)C2	None
		6852400	222716	0	3H-dopamine	-14125	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		6852400	222716	0	3H-SCH23390	-25118	22	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		6852400	222716	0	3H-SCH23390	-25118	22	Rhesus macaque	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	222716	0	3H-dopamine	-14125	22	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	222716	0	3H-SCH23390	-25118	22	Mouse	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	222716	0	3H-SCH23390	-25118	22	Rhesus macaque	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		57174031	222719	0	3H-SCH23390	-1778	20	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	284	2	1	3	3.0	CN1C2CCC1CC(C2)OC(=O)C3=CNC4=CC=CC=C43	None
		None	222722	0	3H-dopamine	-7943	11	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(CC)C(=O)C1CN(C2CC3=CNC4=CC=CC(=C34)C2=C1)C	None
		165193	222724	0	3H-SCH23390	-42657	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		165193	222724	0	3H-SCH23390	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-SCH23390	-42657	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		62882	222724	0	3H-SCH23390	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-SCH23390	-42657	30	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		66366	222724	0	3H-SCH23390	-42657	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	259	6	2	3	2.6	CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O	None
		164512405	222728	0	3H-SCH23390	-457	12	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
		164512405	222728	0	3H-SCH23390	-457	12	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	341	6	2	5	0.6	CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC	None
		11954224	222732	0	3H-SCH23390	-3467	59	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		3246155	222741	0	3H-dopamine	-43651	17	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	307	4	0	2	4.4	CN1C2CCC1CC(C2)OC(C3=CC=CC=C3)C4=CC=CC=C4	None
		11954259	222758	0	3H-dopamine	-7762	43	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		57525649	222769	0	3H-SCH23390	-1	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	187	4	0	1	2.2	CC(CC1=CC=CC=C1)N(C)CC#C	None
		44134711	222770	0	3H-SCH23390	-112201	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	340	6	2	4	2.8	CCC1=CC(=C(C(=C1O)C(=O)NCC2CCCN2CC)OC)Cl	None
		None	222771	0	3H-SCH23390	-1071	11	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.2	C1CN(CCN1CCCC2=CC=CC=C2)CCOC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl	None
		None	222772	0	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	329	2	0	4	3.6	CC1=NC=CN1CC2CCC3=C(C2=O)C4=CC=CC=C4N3C.Cl	None
		6420041	222773	0	3H-SCH23390	-14	5	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	4	0	2	3.8	CN(C)CC=C(C1=CC=C(C=C1)Br)C2=CN=CC=C2	None
		104911	222798	0	3H-SCH23390	-41686	37	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	530	7	0	5	5.1	COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4CCCCC4.Cl.Cl.Cl	None
		None	222806	0	3H-SCH23390	-6309	13	Guinea pig	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	453	9	2	6	2.6	COC1=CC(=C(C=C1C(=O)CCC2CCN(CC2)CCNS(=O)(=O)C)Cl)N.Cl	None
		131632304	222816	0	3H-SCH23390	-70794	13	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	303	4	1	5	0.9	CN1C2CC(CC1C3C2O3)OC(=O)C(CO)C4=CC=CC=C4	None
		119380	222908	0	125I-SCH 23982	-1	8	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	166	1	0	3	1.8	CC1=NOC(=C1)C2CCCN2C	None
		None	222914	0	3H-SCH23390	-10471	23	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		25137849	222958	0	3H-SCH23390	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		71290	222958	0	3H-SCH23390	-4	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	165	3	2	2	1.3	CC(C(C1=CC=CC=C1)O)NC	None
		None	223013	0	3H-SCH23390	-13	6	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
		None	223018	0	3H-SCH23390	-95499	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	316	7	3	3	3.0	CC(CF)NCC(COC1=CC=CC2=C1C3=CC=CC=C3N2)O	None
		None	223033	0	3H-dopamine	-8317	20	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	416	9	3	4	2.8	C1=CC(=CC=C1CCNC(N)SCCCC2=CN=CN2)I	None
		5372683	223065	0	3H-dopamine	-1479	3	Bovine	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	400	5	1	4	4.2	C1CN(CCN1CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO	None
		None	223090	0	3H-SCH23390	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	240	7	4	6	-0.8	C(C(C(=O)O)N)SSCC(C(=O)O)N	None
		None	223091	0	3H-SCH23390	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	4	2	3	0.2	CSCCC(C(=O)O)N	None
		None	223092	0	3H-SCH23390	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	135	3	3	3	-0.3	C(CS)C(C(=O)O)N	None
		None	223093	0	3H-SCH23390	-1	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	121	2	3	3	-0.7	C(C(C(=O)O)N)S	None
		None	223094	0	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	117	0	1	3	-0.0	C1CSC(=O)C1N	None
		None	223095	0	3H-SCH23390	-1	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	153	3	3	3	-1.4	C(C(C(=O)O)N)S(=O)O	None
		None	223096	0	3H-SCH23390	-1	39	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	169	3	3	4	-1.7	C(C(C(=O)O)N)S(=O)(=O)O	None
		None	223097	0	3H-SCH23390	-1	30	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	183	4	3	4	-1.3	C(CS(=O)(=O)O)C(C(=O)O)N	None
		None	223104	0	3H-SCH23390	-13	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	149	2	1	2	1.2	CC(C(=O)C1=CC=CC=C1)N	None
		1576	223105	0	3H-SCH23390	-16	40	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	163	3	1	2	1.5	CC(C(=O)C1=CC=CC=C1)NC	None
		4978	223107	0	3H-SCH23390	-7	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	520	1	7	9	4.3	CC1=CC(=C2C3=C1C4=C5C(=C(C=C4CO)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O	None
		None	223108	0	3H-SCH23390	-3	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	464	4	8	12	-0.6	C1=CC(=C(C=C1C2=C(C(=C3C(=CC(=O)C=C3O2)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O	None
		None	223109	0	3H-SCH23390	-281	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	610	6	10	16	-1.7	CC1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O	None
		None	223110	0	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	448	3	7	11	0.4	CC1C(C(C(C(O1)OC2=C(OC3=CC(=O)C=C(C3=C2O)O)C4=CC(=C(C=C4)O)O)O)O)O	None
		None	223121	0	3H-SCH23390	-1862	19	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	246	2	1	4	1.6	CCCN1CCCC2C1CC3=CN=C(N=C3C2)N	None
		135269	223168	0	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	222	5	1	3	2.5	CCCCC(=O)OC1=CC=CC=C1C(=O)O	None
		23681059	223169	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	230	3	1	2	3.0	CC(C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)O	None
		5018304	223170	0	3H-SCH23390	-1	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	4	1	3	0.0	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]	None
		84003	223171	0	3H-SCH23390	-1	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	376	6	5	7	-0.0	C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O	None
		123619	223172	0	3H-SCH23390	-1412	27	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	358	3	0	4	4.2	CC1=NC=C(C=C1)C2=NC=C(C=C2C3=CC=C(C=C3)S(=O)(=O)C)Cl	None
		119828	223173	0	3H-SCH23390	-1	29	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	370	5	1	5	3.5	CCC(=O)NS(=O)(=O)C1=CC=C(C=C1)C2=C(ON=C2C3=CC=CC=C3)C	None
		None	223174	0	3H-SCH23390	-7	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	517	8	2	5	5.2	CC1=C(C2=C(N1C(=O)C3=CC=C(C=C3)Cl)C=CC(=C2)OC)CC(=O)NCCC4=CC=C(C=C4)NC(=O)C	None
		None	223229	0	UNDEFINED	-660	28	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	223229	0	UNDEFINED	-660	28	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	322	5	2	3	4.1	CC(CC1=CNC2=C1C=C(C=C2)OCC3=CC=CS3)N.Cl	None
		None	223268	0	3H-SCH23390	-4570	26	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	6	0	3	5.0	CC(=O)N(CC1=CC=CC=C1OC)C2=CC=CC=C2OC3=CC=CC=C3	None
		None	223273	0	3H-SCH23390	-1	13	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	399	7	4	5	1.8	CN(C)CC(C1=CC=C(C=C1)O)C2(CCCCC2)O.C(CC(=O)O)C(=O)O.O	None
		None	223346	0	UNDEFINED	-549	6	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		None	223499	0	UNDEFINED	-3090	2	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	3.1	CC1=C(C2=C(CC3C4=C2C=CC=C4CCN3)C=C1)O	None
		None	223501	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	601	23	0	3	11.9	CCCCCCCCCCCCCCCCCCCCCC(=O)OC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)CCC	None
		None	223502	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	363	6	0	3	5.3	CCCCC(=O)OC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)CCC	None
		None	223503	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	3	0	3	4.1	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OC(=O)C	None
		None	223511	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	4.1	CCCN1CCC2=C3C1CC4=C(C=CC(=C4)O)OC3=CC=C2	None
		None	223512	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	4.1	CCCN1CCC2=CC(=CC3=C2C1CC4=CC=CC=C4O3)O	None
		None	223551	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	323	4	1	3	4.3	CCCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		None	223939	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	436	9	2	5	4.7	CCCN(CCCCNC(=O)C1=CC2=CC=CC=C2C=C1)C3CCC4=C(C3)SC(=N4)N	None
		None	224051	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	351	4	0	4	4.2	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)OC(=O)C	None
		None	224052	0	UNDEFINED	-	1	Rat	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	393	7	0	4	5.3	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)CCC)OC	None
		None	224294	0	UNDEFINED	-1023	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	0	0	2	3.8	CC1CC2=C(O1)C3=C(CC4C5=C3C=CC=C5CCN4C)C=C2	None
		None	224295	0	UNDEFINED	-69	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	3	1	3	3.9	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)CC=C)O	None
		None	224296	0	UNDEFINED	-151	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	321	4	0	3	4.0	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)OCC=C	None
		None	224297	0	UNDEFINED	-346	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	0	0	2	4.5	CC1=CC2=C(O1)C3=C(CC4C5=C3C=CC=C5CCN4C)C=C2	None
		None	224298	0	UNDEFINED	-707	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	289	2	0	2	3.5	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC#C	None
		None	224299	0	UNDEFINED	-74	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	2	1	2	3.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC=C)O	None
		None	224300	0	UNDEFINED	-831	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	291	3	0	2	4.0	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C	None
		None	224301	0	UNDEFINED	-19	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	2	0	2	5.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(C=C4)C(=C(O5)C)C	None
		None	224302	0	UNDEFINED	-30	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	317	2	0	2	5.3	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(C=C4)C=C(O5)C	None
		None	224303	0	UNDEFINED	-79	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	331	4	0	2	4.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC#CC	None
		None	224304	0	UNDEFINED	-15	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	2	0	2	4.9	CCCN1CCC2=CC=CC3=C2C1CC4=C3C5=C(CC(O5)(C)C)C=C4	None
		None	224305	0	UNDEFINED	-12	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	4	1	2	4.7	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC=C)O	None
		None	224306	0	UNDEFINED	-67	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	5	0	2	5.6	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C(C)C	None
		None	224307	0	UNDEFINED	-26	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	5	0	2	5.2	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC(=C)C	None
		None	224308	0	UNDEFINED	-35	3	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	319	5	0	2	4.8	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)OCC=C	None
		None	224316	0	UNDEFINED	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	347	4	1	2	5.4	CCCN1CCC2=CC=CC3=C2C1CC4=C(C=CC(=C43)O)CC=C(C)C	None
		None	224317	0	UNDEFINED	1	2	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	333	4	1	2	5.0	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)CC(=C)C)O	None
		1524	8962	96	3H-SCH23390	-338	51	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-SCH23390	-338	51	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-SCH23390	-338	51	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-SCH23390	-338	51	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-SCH23390	-338	51	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-SCH23390	-338	51	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		25058166	222739	0	UNDEFINED	-147	26	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	UNDEFINED	-147	26	Rat	6.0	pKi	=	6	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		126968774	222768	0	3H-dopamine	-42	8	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O	None
		1242	10385	27	3H-SCH23390	-6	17	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390	-6	17	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390	-6	17	Rhesus macaque	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1353	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		45112462	203745	0	UNDEFINED	-831	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	None
		CHEMBL566533	203745	0	UNDEFINED	-831	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	441	8	1	5	4.6	CCOC(=O)c1cc2cc(OCCCN3CCN(c4cccc(Cl)c4)CC3)ccc2[nH]1	None
		25058166	222739	0	3H-SCH23390 Low	-6	26	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-SCH23390 Low	-6	26	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		3153	7085	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		932	7085	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		CHEMBL26736	7085	28	3H-dopamine	-39	8	Bovine	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		1212	8443	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-SCH23390	-14	65	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		681	8247	72	3H-dopamine	-23	38	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-dopamine	-23	38	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-dopamine	-23	38	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-dopamine	-23	38	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-dopamine	-23	38	Bovine	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1353	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	223498	0	UNDEFINED	-190	2	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	237	0	2	2	2.8	C1CNC2CC3=C(C4=C2C1=CC=C4)C(=CC=C3)O	None
		2726	7706	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-SCH23390	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1218	10388	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		938	10388	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		CHEMBL353335	10388	30	3H-SCH23390	-11	8	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	None
		2726	7706	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-SCH23390	-186	72	Bovine	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		None	223738	0	UNDEFINED	1	3	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	365	5	0	4	4.5	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
		277	8083	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-SCH23390	-33	50	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1353	8692	93	3H-SCH233930	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH233930	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH233930	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH233930	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH233930	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	9688	112	3H-SCH23390	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	9688	112	UNDEFINED	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	UNDEFINED	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	UNDEFINED	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	UNDEFINED	-26	65	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2435	10362	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	UNDEFINED	-43	48	Rat	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		1353	8692	93	UNDEFINED	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	UNDEFINED	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	UNDEFINED	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	UNDEFINED	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	UNDEFINED	-38	85	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		277	8083	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	3H-dopamine	-1445	50	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		4508	9913	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		4866774	9913	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		509	9913	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		838	9913	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		CHEMBL1740	9913	98	3H-dopamine	-239	13	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNCC(c1ccc(c(c1)O)O)O	None
		4249	84954	34	3H-dopamine	-1230	6	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	355	6	1	3	4.1	Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	None
		CHEMBL2104700	84954	34	3H-dopamine	-1230	6	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	355	6	1	3	4.1	Cc1ccc(C2(O)CCN(CCCC(=O)c3ccc(F)cc3)CC2)cc1	None
		681	8247	72	UNDEFINED	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	UNDEFINED	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	UNDEFINED	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	UNDEFINED	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	UNDEFINED	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		None	224144	0	UNDEFINED	-	1	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	409	2	3	4	5.0	CCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O.Cl	None
		2337	10030	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-SCH23390	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		24949690	188385	0	UNDEFINED	-1819	3	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	None
		CHEMBL477200	188385	0	UNDEFINED	-1819	3	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	399	7	0	6	4.6	COc1ccccc1N1CCN(CCCSc2nc3ccccc3s2)CC1	None
		2337	10030	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-SCH233930	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		681	8247	72	125I-SCH 23982	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	125I-SCH 23982	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	125I-SCH 23982	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	125I-SCH 23982	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	125I-SCH 23982	-154	38	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2865	10915	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	UNDEFINED	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		None	223553	0	UNDEFINED	-	1	Rat	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.5	CCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		2337	10030	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	UNDEFINED	-53	62	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		2865	10915	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-SCH233930	-114	53	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		None	224142	0	UNDEFINED	-	1	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	331	1	2	3	4.0	CCN1CCC2=C3C1CC4=C(C3=CC(=C2)C)C(=C(C=C4)O)O.Cl	None
		1242	10385	27	3H-SCH23390 Low	-11	17	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390 Low	-11	17	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390 Low	-11	17	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		2105	9828	37	3H-SCH23390	-123	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	3H-SCH23390	-123	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	3H-SCH23390	-123	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	3H-SCH23390	-123	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	3H-SCH23390	-123	32	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		135409468	8816	69	3H-SCH23390	-12	39	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		333	8816	69	3H-SCH23390	-12	39	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		CHEMBL845	8816	69	3H-SCH23390	-12	39	Human	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	312	1	2	4	1.7	Clc1ccc2c(c1)NC(=c1c(=N2)cccc1)N1CCNCC1	None
		37459	7533	13	3H-SCH23390	-8	24	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-SCH23390	-8	24	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-SCH23390	-8	24	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		1222	8445	49	3H-dopamine	-2344	32	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	8445	49	3H-dopamine	-2344	32	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	8445	49	3H-dopamine	-2344	32	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	8445	49	3H-dopamine	-2344	32	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	8445	49	3H-dopamine	-2344	32	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		2470	10425	50	3H-dopamine	-31622	58	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-dopamine	-31622	58	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-dopamine	-31622	58	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-dopamine	-31622	58	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-dopamine	-31622	58	Bovine	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		135398737	7745	93	3H-SCH23390	-44	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-44	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-44	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-44	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-44	90	Human	6.9	pKi	=	6.9	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		127708	119298	7	UNDEFINED	-22	5	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		CHEMBL329904	119298	7	UNDEFINED	-22	5	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		135	9310	43	3H-SCH23390	-91	56	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-SCH23390	-91	56	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-SCH23390	-91	56	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-SCH23390	-91	56	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-SCH23390	-91	56	Human	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		16362	9899	71	3H-SCH23390	-7413	29	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	3H-SCH23390	-7413	29	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	3H-SCH23390	-7413	29	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	3H-SCH23390	-7413	29	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	3H-SCH23390	-7413	29	Rat	5.9	pKi	=	5.9	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		681	8247	72	3H-SCH23390	-97	38	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-SCH23390	-97	38	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-SCH23390	-97	38	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-SCH23390	-97	38	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-SCH23390	-97	38	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		2389	10104	118	3H-SCH23390	-489	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-489	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-489	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-489	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-489	66	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		None	223738	0	UNDEFINED	-12	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	365	5	0	4	4.5	CCCCC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
		1353	8692	93	UNDEFINED	-74	85	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	UNDEFINED	-74	85	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	UNDEFINED	-74	85	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	UNDEFINED	-74	85	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	UNDEFINED	-74	85	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	223514	0	UNDEFINED	-	1	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	419	3	1	5	3.9	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O)Br	None
		1242	10385	27	3H-SCH23390	-5	17	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390	-5	17	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390	-5	17	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1890	9535	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		4449	9535	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		7247	9535	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		CHEMBL623	9535	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		DB01149	9535	49	3H-SCH23390	-234	16	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	469	10	0	7	3.6	CCc1nn(c(=O)n1CCOc1ccccc1)CCCN1CCN(CC1)c1cccc(c1)Cl	None
		11954259	222758	0	3H-SCH23390	-5011	43	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		71299720	222730	0	3H-SCH23390	-1202	17	Human	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	450	3	2	6	3.0	CN1CCN(CC1)C2=NC3=C(C=CC(=C3)C(F)(F)F)N4C2=CC=C4.C(=CC(=O)O)C(=O)O	None
		1353	8692	93	3H-SCH23390	-107	85	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-107	85	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-107	85	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-107	85	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-107	85	Rhesus macaque	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		134	9292	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-SCH23390	-575	67	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1613	9127	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-SCH23390	-4	44	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		681	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		33630	185736	99	3H-dopamine	-281	28	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL47050	185736	99	3H-dopamine	-281	28	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		24949534	196297	0	UNDEFINED	-2041	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	None
		CHEMBL514074	196297	0	UNDEFINED	-2041	3	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	397	8	0	6	4.5	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3o2)CC1	None
		11653679	187970	1	UNDEFINED	-24	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL476108	187970	1	UNDEFINED	-24	11	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	374	6	0	3	4.7	O=C(CCCN1CCCN(c2ccc(Cl)cc2)CC1)c1ccc(F)cc1	None
		None	223552	0	UNDEFINED	-	1	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	309	3	1	3	3.9	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		5018	10322	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	10322	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	10322	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	10322	13	3H-SCH23390	-28	10	Rat	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		172286	223166	0	3H-SCH23390	1	2	Mouse	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	331	0	0	4	3.6	CN1CCN(CC1)C2=NC3=C(CC4=C2C=CS4)C=CC(=C3)Cl	None
		681	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-dopamine	-23	38	Bovine	7.8	pKi	=	7.8	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		None	223161	0	3H-SCH23390	165	2	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	327	1	1	3	4.4	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OC=C4)O)Cl	None
		None	223505	0	UNDEFINED	-	1	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	343	1	2	3	4.5	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=CC=C4)O)C5=CC=C(C=C5)O	None
		15443	124588	96	3H-dopamine	-257	10	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	None
		CHEMBL340211	124588	96	3H-dopamine	-257	10	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	327	6	0	4	3.0	O=C(CCCN1CCN(c2ccccn2)CC1)c1ccc(F)cc1	None
		5018	10322	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	10322	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	10322	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	10322	13	3H-SCH23390	-28	10	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		3036864	209533	19	125I-Spectramide	-2	27	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1256645	209533	19	125I-Spectramide	-2	27	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL1814790	209533	19	125I-Spectramide	-2	27	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		CHEMBL62	209533	19	125I-Spectramide	-2	27	Rat	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1	None
		2286	9957	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	9957	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	9957	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	9957	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	9957	51	3H-SCH23390	-588	30	Rat	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		100	10577	58	3H-dopamine	-309	54	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-dopamine	-309	54	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-dopamine	-309	54	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-dopamine	-309	54	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-dopamine	-309	54	Bovine	5.8	pKi	=	5.8	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1212	8443	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	UNDEFINED	-51	65	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		11976	7707	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	7707	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	7707	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	7707	59	UNDEFINED	-12	24	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		1212	8443	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-SCH23390	-288	65	Bovine	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1242	10385	27	3H-SCH23390	-1	17	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1242	10385	27	3H-SCH23390	1	17	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390	-1	17	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390	1	17	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390	-1	17	Mouse	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390	1	17	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5281878	8441	35	3H-dopamine	-34	16	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-dopamine	-34	16	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-dopamine	-34	16	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-dopamine	-34	16	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-dopamine	-34	16	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-dopamine	-34	16	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-dopamine	-34	16	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	8443	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-dopamine	-288	65	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1621	9207	17	3H-SCH23390	-588	44	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-SCH23390	-588	44	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-SCH23390	-588	44	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-SCH23390	-588	44	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-SCH23390	-588	44	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		None	223061	0	3H-dopamine	2	2	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	1	2	2	1.5	CN1CC(C=C2C1CC3=CNC4=CC=CC2=C34)C(=O)N	None
		100	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		None	223509	0	UNDEFINED	-	1	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	325	3	2	4	3.6	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)O)O	None
		100	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-dopamine	-309	54	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		30137	9652	0	3H-SCH23390	-676	9	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		8594	9652	0	3H-SCH23390	-676	9	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		934	9652	0	3H-SCH23390	-676	9	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		1153	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		12668023	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026874	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026875	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		3341	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		6603851	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		933	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		939	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		985	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1160786	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1161520	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL588	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		DB00800	8409	58	3H-SCH23390	-32	10	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		None	223149	0	3H-SCH23390	-11220	2	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	487	8	2	4	3.9	CNC1=C(C=C(C(=C1)OC)C(=O)NCCN(C)CC2=CC=C(C=C2)I)Cl	None
		135398737	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1524	8962	96	3H-SCH23390	-79	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-SCH23390	-79	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-SCH23390	-79	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-SCH23390	-79	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-SCH23390	-79	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-SCH23390	-79	51	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		None	223063	0	3H-dopamine	-741	2	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	454	6	1	4	4.8	C1CN(CCN1CCCC2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F)CCO	None
		135398737	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-44	90	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		242	7258	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		242	7258	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-SCH23390	-281	51	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	UNDEFINED	-74	51	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		4106	9280	22	3H-SCH23390	-5	33	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-SCH23390	-5	33	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-SCH23390	-5	33	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-SCH23390	-5	33	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		None	223517	0	UNDEFINED	-	1	Rat	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	453	2	2	5	3.5	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O)I	None
		37459	7533	13	3H-SCH23390	-53	24	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-SCH23390	-53	24	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-SCH23390	-53	24	Bovine	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		6603820	102549	19	3H-SCH23390	1	12	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	3H-SCH23390	1	12	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		1238	209953	24	3H-SCH23390	-5	16	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	209953	24	3H-SCH23390	-5	16	Rat	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		3153	7085	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		932	7085	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		CHEMBL26736	7085	28	3H-SCH23390 High	-39	8	Bovine	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		46780481	114308	20	3H-SCH23390	-29	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-SCH23390	-29	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-SCH23390	-29	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-SCH23390	-29	53	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		20840341	222956	0	3H-SCH23390	-3	4	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	451	5	1	3	6.2	C1CN(CCC1CCO)CCC=C2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F	None
		6603820	102549	19	3H-SCH23390	-2	12	Rhesus macaque	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	3H-SCH23390	-2	12	Rhesus macaque	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		1524	8962	96	3H-SCH23390	-338	51	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-SCH23390	-338	51	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-SCH23390	-338	51	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-SCH23390	-338	51	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-SCH23390	-338	51	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-SCH23390	-338	51	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		484	9633	51	3H-dopamine	-4	35	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	3H-dopamine	-4	35	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	3H-dopamine	-4	35	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		None	223500	0	UNDEFINED	-165	2	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	293	2	1	2	4.2	CCCN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)C)O	None
		24949857	188546	0	UNDEFINED	-7413	3	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	None
		CHEMBL477765	188546	0	UNDEFINED	-7413	3	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	413	8	0	6	5.0	COc1ccccc1N1CCN(CCCCSc2nc3ccccc3s2)CC1	None
		25212275	181200	0	UNDEFINED	-4897	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL455288	181200	0	UNDEFINED	-4897	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	682	13	0	8	7.4	O=C(OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1)c1ccc(OCCCN2CCCCC2)cc1	None
		25212276	196845	0	UNDEFINED	-575	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL517244	196845	0	UNDEFINED	-575	6	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	508	11	0	3	7.4	CN(CCCC12CCC(c3ccccc31)c1ccccc12)Cc1ccc(OCCCN2CCCCC2)cc1	None
		3151	8244	97	3H-SCH23390	-2630	26	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		945	8244	97	3H-SCH23390	-2630	26	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		965	8244	97	3H-SCH23390	-2630	26	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		CHEMBL219916	8244	97	3H-SCH23390	-2630	26	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		DB01184	8244	97	3H-SCH23390	-2630	26	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	425	5	2	5	3.4	Clc1ccc2c(c1)[nH]c(=O)n2C1CCN(CC1)CCCn1c(=O)[nH]c2c1cccc2	None
		135398737	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-dopamine	-204	90	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		126968774	222768	0	3H-SCH23390	-831	8	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C)CC1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CN(C5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O	None
		5475158	73987	25	3H-SCH23390	-489	14	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		CHEMBL18786	73987	25	3H-SCH23390	-489	14	Bovine	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	340	8	1	3	4.4	CN(C)CCCSc1ccccc1NC(=O)/C=C/c1ccccc1	None
		1212	8443	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-SCH23390	-51	65	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2389	10104	118	UNDEFINED	-346	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	UNDEFINED	-346	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	UNDEFINED	-346	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	UNDEFINED	-346	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	UNDEFINED	-346	66	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		100	10577	58	3H-SCH23390	-16	54	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-SCH23390	-16	54	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-SCH23390	-16	54	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-SCH23390	-16	54	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-SCH23390	-16	54	Rat	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		6603820	102549	19	3H-SCH23390	-4	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	3H-SCH23390	-4	12	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		None	223164	0	125I-SCH 23982	74	2	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	365	2	3	4	3.7	C1C2CC3CC1CC(C2)(C3)C4CC5=C(C=CC(=C5O)O)C(O4)CN.Cl	None
		4106	9280	22	3H-dopamine	-524	33	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		5358812	9280	22	3H-dopamine	-524	33	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		89	9280	22	3H-dopamine	-524	33	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		CHEMBL93240	9280	22	3H-dopamine	-524	33	Bovine	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	356	2	0	4	4.4	CSc1ccc2c(c1)C(Cc1c(S2)cccc1)N1CCN(CC1)C	None
		2435	10362	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	3H-SCH23390	-43	48	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		25058166	222739	0	UNDEFINED	-147	26	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	UNDEFINED	-147	26	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		None	223515	0	UNDEFINED	-	1	Rat	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	481	4	0	5	4.1	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC)I	None
		None	223120	0	3H-SCH23390	-281	19	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	451	8	2	4	3.2	CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C	None
		3294	8787	111	3H-SCH23390	-56	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	3H-SCH23390	-56	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	3H-SCH23390	-56	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	3H-SCH23390	-56	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	3H-SCH23390	-56	44	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		134	9292	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-SCH23390	-186	67	Rat	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		None	223012	0	3H-SCH23390	-3090	3	Human	5.7	pKi	=	5.7	Binding	NoneNone	PDSP KiDatabase	315	6	1	3	4.3	CCCN(CCC1=CC=CS1)C2CCC3=C(C2)C=CC=C3O	None
		2398	7741	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	7741	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	7741	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	7741	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	7741	62	3H-SCH23390	-11	29	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		10742	10389	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		1225	10389	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		CHEMBL35354	10389	31	3H-SCH23390	-2	8	Human	7.7	pKi	=	7.7	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		2470	10425	50	3H-SCH23390	-4168	58	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-SCH23390	-4168	58	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-SCH23390	-4168	58	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-SCH23390	-4168	58	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-SCH23390	-4168	58	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		4382	111557	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
		86470	111557	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
		CHEMBL1256484	111557	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
		CHEMBL31088	111557	31	3H-dopamine	22	2	Bovine	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	167	3	3	3	0.9	CNCCc1ccc(O)c(O)c1	None
		1212	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2389	10104	118	3H-SCH23390	-346	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-346	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-346	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-346	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-346	66	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		44591134	182979	0	UNDEFINED	-194	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL459373	182979	0	UNDEFINED	-194	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	535	11	0	5	7.7	CN(CCCN1c2ccccc2Sc2ccc(Cl)cc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		681	8247	72	3H-SCH23390	-154	38	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-SCH23390	-154	38	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-SCH23390	-154	38	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-SCH23390	-154	38	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-SCH23390	-154	38	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1212	8443	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-SCH23390	-51	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		46780481	114308	20	3H-SCH23390	-64	53	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-SCH23390	-64	53	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-SCH23390	-64	53	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-SCH23390	-64	53	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		None	223506	0	UNDEFINED	-	1	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	341	3	1	5	3.2	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O	None
		1212	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-dopamine	-288	65	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2181	9902	46	3H-SCH23390	-2041	34	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	9902	46	3H-SCH23390	-2041	34	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	9902	46	3H-SCH23390	-2041	34	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	9902	46	3H-SCH23390	-2041	34	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	9902	46	3H-SCH23390	-2041	34	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		None	223940	0	UNDEFINED	-158	6	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	532	10	0	4	8.0	CN(CCC=C1C2=CC=CC=C2SC3=C1C=C(C=C3)Cl)CC4=CC=C(C=C4)OCCCN5CCCCC5	None
		2726	7706	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		2726	7706	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-SCH23390	-14	72	Mouse	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-SCH23390	-18	72	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	9688	112	3H-SCH23390	-26	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398745	9688	112	UNDEFINED	-23	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-26	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	UNDEFINED	-23	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-26	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	UNDEFINED	-23	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-26	65	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	UNDEFINED	-23	65	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		11976	7707	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	7707	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	7707	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	7707	59	3H-dopamine	-234	24	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	9688	112	3H-SCH23390	-23	65	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-23	65	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-23	65	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-23	65	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135	9310	43	3H-dopamine	-457	56	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-dopamine	-457	56	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-dopamine	-457	56	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-dopamine	-457	56	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-dopamine	-457	56	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		None	223739	0	UNDEFINED	-7	2	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	339	0	3	6	3.0	CN1CCC2=C3C1CC4=C(C3=CC5=C2SC(=N5)N)C(=C(C=C4)O)O	None
		None	223555	0	UNDEFINED	1	4	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	251	0	1	2	3.1	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)O	None
		1242	10385	27	3H-SCH23390	1	17	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390	1	17	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390	1	17	Rat	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		73333	12735	31	UNDEFINED	-16	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL1079935	12735	31	UNDEFINED	-16	9	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	401	7	1	2	4.2	CCNC(=O)N1CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		4452	9538	19	3H-SCH23390	-89125	18	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		983	9538	19	3H-SCH23390	-89125	18	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		CHEMBL20734	9538	19	3H-SCH23390	-89125	18	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	387	6	2	4	3.8	COc1cc(NC)c(cc1C(=O)NC1CCN(C1C)Cc1ccccc1)Cl	None
		2337	10030	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-SCH23390	-134	62	Rat	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398737	7745	93	3H-SCH23390	-37	90	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-37	90	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-37	90	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-37	90	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-37	90	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2389	10104	118	3H-SCH23390	-489	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-489	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-489	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-489	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-489	66	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		1353	8692	93	3H-SCH23390	-30	85	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-30	85	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-30	85	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-30	85	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-30	85	Pig	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-SCH23390	-38	85	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-38	85	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-38	85	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-38	85	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-38	85	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	223497	0	UNDEFINED	-60	2	Rat	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	263	1	0	1	4.0	CCC1=CC=CC2=C1C3=C4C(C2)N(CCC4=CC=C3)C	None
		None	222717	0	3H-SCH23390	-45708	21	Human	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	583	4	3	6	2.1	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CC6C(CC7=CNC8=CC=CC6=C78)N(C5)C	None
		None	224145	0	UNDEFINED	-	1	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	345	2	2	3	4.4	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)C)C(=C(C=C4)O)O.Cl	None
		1153	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		12668023	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026874	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026875	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		3341	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		6603851	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		933	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		939	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		985	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1160786	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1161520	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL588	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		DB00800	8409	58	3H-SCH23390	-32	10	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		2601	10552	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	10552	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	10552	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	10552	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	10552	33	3H-SCH23390	-16	21	Human	7.6	pKi	=	7.6	Binding	NoneNone	PDSP KiDatabase	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		1028	7079	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		139148732	7079	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		479	7079	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		5816	7079	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		CHEMBL679	7079	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		DB00668	7079	71	3H-dopamine	-52	30	Bovine	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	183	3	4	4	0.4	CNC[C@@H](c1ccc(c(c1)O)O)O	None
		135398737	7745	93	3H-dopamine	-204	90	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-dopamine	-204	90	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-dopamine	-204	90	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-dopamine	-204	90	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-dopamine	-204	90	Bovine	5.6	pKi	=	5.6	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		125564	7453	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		388	7453	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		7670	7453	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		CHEMBL178803	7453	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		DB09223	7453	97	3H-SCH23390	-5011	7	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	367	3	0	3	4.7	CCN1CCN(CC1)c1nc2CCCCCCc2c(c1)c1ccc(cc1)F	None
		135398737	7745	93	3H-SCH233930	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH233930	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH233930	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH233930	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH233930	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		209	9831	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	9831	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	9831	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	9831	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	9831	97	3H-SCH23390	-51	23	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		135398737	7745	93	UNDEFINED	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	UNDEFINED	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	UNDEFINED	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	UNDEFINED	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	UNDEFINED	-44	90	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		134	9292	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	3H-dopamine	-575	67	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		25058166	222739	0	UNDEFINED	-144	26	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	UNDEFINED	-144	26	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		None	223508	0	UNDEFINED	-	1	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.9	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O	None
		10145	223507	0	UNDEFINED	-	1	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	355	4	0	5	3.5	CN1CCC2=CC(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC	None
		None	223736	0	UNDEFINED	-1	2	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	265	0	2	3	2.6	CN1CCC2=C3C1CC4=C(C3=CC(=C2)N)C(=CC=C4)N	None
		185	10778	60	3H-SCH23390	-6606	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	10778	60	3H-SCH23390	-6606	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	10778	60	3H-SCH23390	-6606	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	10778	60	3H-SCH23390	-6606	37	Human	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		122324	6993	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
		6077	6993	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
		CHEMBL86931	6993	22	125I-SCH 23982	323	3	Rat	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	271	2	3	4	2.4	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)c1ccccc1	None
		37459	7533	13	3H-SCH23390	-10	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-SCH23390	-10	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-SCH23390	-10	24	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		5281878	8441	35	3H-SCH23390	-2	16	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-2	16	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-2	16	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-2	16	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-2	16	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-2	16	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-2	16	Human	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281878	8441	35	3H-SCH23390	-34	16	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-34	16	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-34	16	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-34	16	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-34	16	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-34	16	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-34	16	Bovine	8.5	pKi	=	8.5	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		9861622	206223	5	3H-SCH23390	1202	2	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	None
		CHEMBL59139	206223	5	3H-SCH23390	1202	2	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	313	0	1	2	4.0	CN1CCc2cc(Cl)c(O)cc2C2c3ccccc3CCC21	None
		62865	8057	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	8057	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	8057	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	8057	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	8057	0	3H-SCH23390	-2	15	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		1621	9207	17	3H-dopamine	-97	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	3H-dopamine	-97	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	3H-dopamine	-97	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	3H-dopamine	-97	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	3H-dopamine	-97	44	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2865	10915	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-SCH23390	-114	53	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		11954224	222732	0	3H-dopamine	-426	59	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		1242	10385	27	3H-SCH23390 High	-11	17	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390 High	-11	17	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390 High	-11	17	Bovine	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1427	8794	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		357	8794	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		3696	8794	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL11	8794	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		DB00458	8794	54	3H-SCH23390	-295	27	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	280	4	0	2	3.9	CN(CCCN1c2ccccc2CCc2c1cccc2)C	None
		10333195	54960	0	UNDEFINED	-10	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
		CHEMBL155208	54960	0	UNDEFINED	-10	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
		44591099	182969	0	UNDEFINED	-1122	6	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL459350	182969	0	UNDEFINED	-1122	6	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	494	10	0	3	7.0	CN(CCC=C1c2ccccc2CCc2ccccc21)Cc1ccc(OCCCN2CCCCC2)cc1	None
		135398745	9688	112	3H-SCH23390	-23	65	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-23	65	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-23	65	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-23	65	Rat	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		None	224143	0	UNDEFINED	-	1	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	393	2	2	3	5.3	CCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5.Cl	None
		1353	8692	93	3H-SCH23390	-512	85	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-512	85	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-512	85	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-512	85	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-512	85	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	UNDEFINED	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	UNDEFINED	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	UNDEFINED	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	UNDEFINED	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	UNDEFINED	-74	85	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135	9310	43	3H-SCH23390	-457	56	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-SCH23390	-457	56	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-SCH23390	-457	56	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-SCH23390	-457	56	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-SCH23390	-457	56	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		6852400	222716	0	3H-SCH23390	-14125	22	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	222716	0	3H-SCH23390	-14125	22	Bovine	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		186	8588	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		71781	8588	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		CHEMBL18972	8588	52	3H-SCH23390	-53	17	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	295	5	1	2	3.7	OC(c1ccccc1)C1CCN(CC1)CCc1ccccc1	None
		11696813	194697	12	UNDEFINED	-316	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
		CHEMBL496739	194697	12	UNDEFINED	-316	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	391	7	1	4	4.1	Cc1cccc(N2CCN(CCCCNC(=O)c3cc4ccccc4o3)CC2)c1	None
		6603820	102549	19	125I-SCH 23982	-4	12	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	125I-SCH 23982	-4	12	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		2865	10915	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	3H-SCH23390	-114	53	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		2105	9828	37	3H-SCH23390	-123	32	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	3H-SCH23390	-123	32	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	3H-SCH23390	-123	32	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	3H-SCH23390	-123	32	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	3H-SCH23390	-123	32	Human	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		1212	8443	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-dopamine	-288	65	Bovine	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		None	223346	0	UNDEFINED	-549	6	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		30137	9652	0	UNDEFINED	-3981	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		8594	9652	0	UNDEFINED	-3981	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		934	9652	0	UNDEFINED	-3981	9	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		135398745	9688	112	3H-SCH23390	-26	65	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-26	65	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-26	65	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-26	65	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		6603820	102549	19	3H-SCH23390	-4	12	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	3H-SCH23390	-4	12	Human	7.5	pKi	=	7.5	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		10707972	175835	0	UNDEFINED	1	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
		CHEMBL439639	175835	0	UNDEFINED	1	2	Rat	5.5	pKi	=	5.5	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cc(O)cc3c2C1Cc1ccccc1O3	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	UNDEFINED	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	UNDEFINED	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	UNDEFINED	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	UNDEFINED	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	UNDEFINED	-83	90	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2470	10425	50	3H-SCH23390	-51286	58	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-SCH23390	-51286	58	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-SCH23390	-51286	58	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-SCH23390	-51286	58	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-SCH23390	-51286	58	Rat	6.5	pKi	=	6.5	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1353	8692	93	3H-SCH23390	-38	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-38	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-38	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-38	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-38	85	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		73453	36389	24	3H-dopamine	-51	17	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		CHEMBL1385840	36389	24	3H-dopamine	-51	17	Bovine	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	561	4	3	6	2.0	CC(C)[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]cc(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12	None
		2470	10425	50	3H-SCH23390	-10964	58	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-SCH23390	-10964	58	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-SCH23390	-10964	58	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-SCH23390	-10964	58	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-SCH23390	-10964	58	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		25293	222744	0	3H-dopamine	-724	4	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	443	6	1	3	5.4	C1CN(CCC1(C2=CC(=C(C=C2)Cl)C(F)(F)F)O)CCCC(=O)C3=CC=C(C=C3)F	None
		44448059	101595	0	UNDEFINED	5	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
		CHEMBL253530	101595	0	UNDEFINED	5	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	251	0	2	2	2.7	Oc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
		25058166	222739	0	3H-SCH23390	-144	26	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-SCH23390	-144	26	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		213	10625	55	3H-SCH23390	-12	43	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	10625	55	3H-SCH23390	-12	43	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	10625	55	3H-SCH23390	-12	43	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	10625	55	3H-SCH23390	-12	43	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	10625	55	3H-SCH23390	-12	43	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		681	8247	72	3H-SCH23390	-97	38	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-SCH23390	-97	38	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-SCH23390	-97	38	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-SCH23390	-97	38	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-SCH23390	-97	38	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		13994416	197469	1	UNDEFINED	-851	2	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1C(C2)N(C)CC3	None
		CHEMBL5181992	197469	1	UNDEFINED	-851	2	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.5	Cc1ccc2c(c1O)-c1cccc3c1C(C2)N(C)CC3	None
		5018	10322	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	10322	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	10322	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	10322	13	3H-SCH23390	-194	10	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		5770	211837	82	3H-SCH23390	-2	7	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
		CHEMBL772	211837	82	3H-SCH23390	-2	7	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
		242	7258	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-SCH23390	-281	51	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2337	10030	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	UNDEFINED	-134	62	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		1524	8962	96	3H-SCH23390	-301	51	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-SCH23390	-301	51	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-SCH23390	-301	51	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-SCH23390	-301	51	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-SCH23390	-301	51	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-SCH23390	-301	51	Bovine	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		5281878	8441	35	3H-SCH23390	-2	16	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-2	16	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-2	16	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-2	16	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-2	16	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-2	16	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-2	16	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		37459	7533	13	3H-SCH23390	-10	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-SCH23390	-10	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-SCH23390	-10	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		1577	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		2537	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5355	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5501	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		643497	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		688272	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		958	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		960	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL196677	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL26	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		CHEMBL267044	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB00391	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		DB16021	10475	110	None	-69	20	Bovine	8.4	pKi	=	8.4	Binding	In vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membraneIn vitro displacement of [3H]- SCH 23390 from the dopamine receptor D1 of bovine striatal membrane	Drug Central	341	6	2	5	0.6	CCN1CCC[C@@H]1CNC(=O)c1cc(ccc1OC)S(=O)(=O)N	None
		5281878	8441	35	3H-SCH23390	-11	16	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-11	16	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-11	16	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-11	16	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-11	16	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-11	16	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-11	16	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2402	10143	62	None	-61	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		5095	10143	62	None	-61	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		7295	10143	62	None	-61	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		CHEMBL589	10143	62	None	-61	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		DB00268	10143	62	None	-61	24	Human	8.4	pKi	=	8.4	Binding	NoneNone	Drug Central	260	7	1	2	3.5	CCCN(CCC)CCc1cccc2c1CC(=N2)O	None
		1212	8443	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1212	8443	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-SCH23390	-8	65	Mouse	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-SCH23390	-14	65	Rat	8.4	pKi	=	8.4	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		10742	10389	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		1225	10389	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		CHEMBL35354	10389	31	3H-SCH23390	2	8	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	329	3	2	3	3.9	C=CCN1CCc2c(C(C1)c1ccccc1)cc(c(c2Cl)O)O	None
		6603820	102549	19	3H-SCH23390	1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	3H-SCH23390	1	12	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		2662	18156	131	None	-3	30	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		CHEMBL118	18156	131	None	-3	30	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	381	3	1	4	3.5	Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1	None
		441383	27105	57	None	-12	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		CHEMBL1306	27105	57	None	-12	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	531	8	0	8	4.5	CC(C)N1CCN(c2ccc(OC[C@H]3CO[C@](Cn4cncn4)(c4ccc(Cl)cc4Cl)O3)cc2)CC1	None
		28417	46813	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		CHEMBL1479	46813	49	None	-1	12	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	337	0	1	3	4.2	C#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=Cc5oncc5C[C@]4(C)[C@H]3CC[C@@]21C	None
		2105	9828	37	3H-SCH23390	-147	32	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		2105	9828	37	3H-SCH23390	-147	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	3H-SCH23390	-147	32	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	3H-SCH23390	-147	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	3H-SCH23390	-147	32	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	3H-SCH23390	-147	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	3H-SCH23390	-147	32	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	3H-SCH23390	-147	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	3H-SCH23390	-147	32	Mouse	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	3H-SCH23390	-147	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		25058166	222739	0	3H-SCH23390	-144	26	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-SCH23390	-144	26	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		4011	89183	49	UNDEFINED	-64	24	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	89183	49	UNDEFINED	-64	24	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		135398737	7745	93	3H-SCH23390	-169	90	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-169	90	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-169	90	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-169	90	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-169	90	Rhesus macaque	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5018	10322	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		943	10322	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		946	10322	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		CHEMBL13668	10322	13	3H-SCH23390	2	10	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	None
		115237	62359	119	3H-SCH23390	-74	54	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-SCH23390	-74	54	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		1242	10385	27	3H-SCH23390	1	17	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390	1	17	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390	1	17	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		242	7258	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	3H-SCH23390	-74	51	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		16363	7383	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		312	7383	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		9215	7383	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL297302	7383	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB12867	7383	53	3H-dopamine	-20892	7	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	381	6	1	4	3.8	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		16362	9899	71	3H-dopamine	-30199	29	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	3H-dopamine	-30199	29	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	3H-dopamine	-30199	29	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	3H-dopamine	-30199	29	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	3H-dopamine	-30199	29	Bovine	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		1816	9318	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	9318	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	9318	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	9318	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	9318	102	3H-SCH23390	-323	18	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		3294	8787	111	3H-SCH23390	-56	44	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	3H-SCH23390	-56	44	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	3H-SCH23390	-56	44	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	3H-SCH23390	-56	44	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	3H-SCH23390	-56	44	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2337	10030	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-SCH23390	-134	62	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135	9310	43	3H-MIANSERIN	-91	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	3H-MIANSERIN	-91	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	3H-MIANSERIN	-91	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	3H-MIANSERIN	-91	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	3H-MIANSERIN	-91	56	Human	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		44448070	101668	0	UNDEFINED	3	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	None
		CHEMBL254147	101668	0	UNDEFINED	3	2	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	295	2	1	3	3.0	COc1cc2c3c(c1OC)Cc1ccccc1CC3NCC2	None
		25186021	194803	0	UNDEFINED	-1318	3	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	None
		CHEMBL497574	194803	0	UNDEFINED	-1318	3	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2ccc(Cl)cc2Cl)CC1	None
		25058166	222739	0	3H-SCH23390	-147	26	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-SCH23390	-147	26	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		11712530	194669	0	UNDEFINED	-41686	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	None
		CHEMBL496531	194669	0	UNDEFINED	-41686	4	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	470	6	0	4	5.0	O=C1c2cc3ccccc3n2CCN1CCCCN1CCN(c2cccc(Cl)c2Cl)CC1	None
		2726	7706	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-SCH23390	-36	72	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		209	9831	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2113	9831	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4748	9831	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL567	9831	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00850	9831	97	3H-SCH23390	-51	23	Rat	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	403	6	1	5	3.9	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		None	223346	0	UNDEFINED	-549	6	Rat	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		681	8247	72	3H-SCH23390	-154	38	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-SCH23390	-154	38	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-SCH23390	-154	38	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-SCH23390	-154	38	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-SCH23390	-154	38	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		1222	8445	49	3H-SCH23390	-741	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3396	8445	49	3H-SCH23390	-741	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		85	8445	49	3H-SCH23390	-741	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL46516	8445	49	3H-SCH23390	-741	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		DB04842	8445	49	3H-SCH23390	-741	32	Rat	6.4	pKi	=	6.4	Binding	NoneNone	PDSP KiDatabase	475	7	1	3	5.3	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		None	222750	0	3H-SCH23390	-9772	15	Human	5.4	pKi	=	5.4	Binding	NoneNone	PDSP KiDatabase	473	7	0	5	3.5	COC1=CC=CC=C1N2CCN(CC2)CCCCN3C(=O)C4=CC=CC=C4C3=O.Br	None
		2337	10030	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-SCH23390	-134	62	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		135398745	9688	112	3H-SCH23390	-23	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-23	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-23	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-23	65	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		None	223554	0	UNDEFINED	1	4	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.2	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		None	223554	0	UNDEFINED	-1	4	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.2	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)O	None
		25186569	183761	0	UNDEFINED	-45708	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	None
		CHEMBL462508	183761	0	UNDEFINED	-45708	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	456	7	1	4	4.9	O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cc2ccccc2cn1	None
		None	223011	0	3H-SCH23390	-11	4	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	226	0	2	2	1.4	C1CCC(=O)NCCCCCC(=O)NCC1	None
		1524	8962	96	3H-SCH23390	-79	51	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	3H-SCH23390	-79	51	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	3H-SCH23390	-79	51	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	3H-SCH23390	-79	51	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	3H-SCH23390	-79	51	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	3H-SCH23390	-79	51	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		219050	10146	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		52	10146	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		CHEMBL431367	10146	25	3H-SCH23390	-2884	21	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	346	6	2	2	5.0	Oc1ccc2c(c1)c(CCCCN1CCC(=CC1)c1ccccc1)c[nH]2	None
		5281878	8441	35	3H-SCH23390	-4	16	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281878	8441	35	3H-SCH23390	-11	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-4	16	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-11	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-4	16	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-11	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-4	16	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-11	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-4	16	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-11	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-4	16	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-11	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-4	16	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-11	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		30137	9652	0	3H-SCH23390	-1202	9	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		8594	9652	0	3H-SCH23390	-1202	9	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		934	9652	0	3H-SCH23390	-1202	9	Mouse	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		6446379	223064	0	3H-dopamine	-154	2	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	472	5	1	4	5.1	C1CN(CCN1CC/C=C/2\C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO.Cl.Cl	None
		10264969	55069	0	UNDEFINED	-6	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
		CHEMBL155352	55069	0	UNDEFINED	-6	2	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	267	0	1	3	3.3	CN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
		None	223518	0	UNDEFINED	-	1	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	405	2	2	5	3.6	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)O)OC)O)Br	None
		2181	9902	46	3H-dopamine	-4073	34	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		4830	9902	46	3H-dopamine	-4073	34	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		92	9902	46	3H-dopamine	-4073	34	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		CHEMBL440294	9902	46	3H-dopamine	-4073	34	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		DB09286	9902	46	3H-dopamine	-4073	34	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	375	7	1	4	2.6	O=C(c1ccc(cc1)F)CCCN1CCC(CC1)(N1CCCCC1)C(=O)N	None
		None	223346	0	UNDEFINED	-549	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		46780481	114308	20	3H-SCH23390	-64	53	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	3H-SCH23390	-64	53	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	3H-SCH23390	-64	53	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	3H-SCH23390	-64	53	Rat	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		64143	205643	62	None	-1	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	None
		CHEMBL584	205643	62	None	-1	8	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	567	9	4	6	4.7	Cc1c(O)cccc1C(=O)N[C@@H](CSc1ccccc1)[C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C	None
		2477	7532	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		36	7532	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		437	7532	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		CHEMBL49	7532	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		DB00490	7532	59	None	-28	29	Bovine	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatumInhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum	Drug Central	385	6	0	6	2.1	O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1	None
		2780	117306	36	None	-138	10	Bovine	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	Drug Central	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
		CHEMBL325109	117306	36	None	-138	10	Bovine	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranesDisplacement of [3H]SCH-23390 [0.3 nM (Kd=0.35 nM)] from dopamine receptor D1 in bovine striatal membranes	Drug Central	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
		176	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2157	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		2566	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		CHEMBL633	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		DB01118	7186	66	None	-4	31	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	645	11	0	4	6.9	CCCCc1oc2c(c1C(=O)c1cc(I)c(c(c1)I)OCCN(CC)CC)cccc2	None
		3198	212292	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL1201049	212292	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		CHEMBL808	212292	76	None	-31	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	380	6	0	3	5.8	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)cc1	None
		2812	11551	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		CHEMBL104	11551	101	None	-32	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	344	4	0	2	5.4	Clc1ccccc1C(c1ccccc1)(c1ccccc1)n1ccnc1	None
		1016	10519	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2561	10519	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		2733526	10519	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		5384	10519	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		CHEMBL83	10519	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		DB00675	10519	78	None	-29	35	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	371	8	0	2	6.0	CC/C(=C(\c1ccccc1)/c1ccc(cc1)OCCN(C)C)/c1ccccc1	None
		1816	9318	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	9318	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	9318	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	9318	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	9318	102	None	-323	18	Rat	8.3	pKi	=	8.3	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		1816	9318	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		4205	9318	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		7241	9318	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		CHEMBL654	9318	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		DB00370	9318	102	None	-323	18	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	265	0	0	3	2.5	CN1CCN2C(C1)c1ccccc1Cc1c2nccc1	None
		448537	167029	89	None	-28	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		CHEMBL411	167029	89	None	-28	25	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	268	4	2	2	4.8	CC/C(=C(/CC)c1ccc(O)cc1)c1ccc(O)cc1	None
		4189	213701	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1559	213701	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL91	213701	96	None	-25	34	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	414	6	0	3	6.5	Clc1ccc(COC(Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		1042	8362	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		148	8362	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		443884	8362	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		CHEMBL119443	8362	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		DB01253	8362	23	None	-204	17	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		2407	10145	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		59227	10145	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		941	10145	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		CHEMBL1303	10145	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		DB05271	10145	76	None	-128	7	Human	8.3	pKi	=	8.3	Binding	NoneNone	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		5353853	24758	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		9556529	24758	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		CHEMBL1262	24758	47	None	-19	15	Human	8.3	pKi	=	8.3	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	427	6	0	4	6.1	Clc1ccc(CO/N=C(\Cn2ccnc2)c2ccc(Cl)cc2Cl)c(Cl)c1	None
		11154555	7587	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		5037	7587	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		7671	7587	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL2028019	7587	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL3085826	7587	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB06016	7587	62	None	-1445	12	Human	8.3	pKi	=	8.3	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assay	Drug Central	426	5	1	3	4.3	O=C(N(C)C)N[C@@H]1CC[C@H](CC1)CCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		2247	7293	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		249	7293	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		2603	7293	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		CHEMBL296419	7293	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		DB00637	7293	81	None	-61	42	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	458	8	1	5	5.4	COc1ccc(cc1)CCN1CCC(CC1)Nc1nc2c(n1Cc1ccc(cc1)F)cccc2	None
		12488	8438	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		941361	8438	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		CHEMBL30008	8438	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		DB04841	8438	56	None	-19	23	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	404	6	0	2	5.4	C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F	None
		2351	10059	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		2820	10059	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		5035	10059	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		CHEMBL81	10059	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		DB00481	10059	64	None	-16	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	473	7	2	6	6.1	Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O	None
		240	7731	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		2769	7731	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		44279790	7731	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		660	7731	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL1729	7731	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		CHEMBL560739	7731	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		DB00604	7731	43	None	-19	25	Rat	8.2	pKi	=	8.2	Binding	The ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striataThe ability to inhibit [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striata	Drug Central	465	9	2	6	3.4	COC1CN(CCCOc2ccc(cc2)F)CCC1NC(=O)c1cc(Cl)c(cc1OC)N	None
		1830	9368	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		207	9368	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		23897	9368	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		CHEMBL460	9368	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		DB01618	9368	44	None	-16	28	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	276	3	1	3	2.0	CCc1c(C)[nH]c2c1C(=O)C(CC2)CN1CCOCC1	None
		None	223162	0	3H-SCH23390	1737	2	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	340	2	1	5	2.9	CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC4=C3OCC4)O)[N+](=O)[O-]	None
		11057	182928	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		3468	182928	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL459265	182928	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		CHEMBL64894	182928	23	None	-2	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	372	4	0	2	4.5	CN(C)c1ccc(C(=C2C=CC(=[N+](C)C)C=C2)c2ccc(N(C)C)cc2)cc1	None
		135	9310	43	None	-46	56	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	None	-46	56	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	None	-46	56	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	None	-46	56	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	None	-46	56	Rat	8.2	pKi	=	8.2	Binding	Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1Inhibition of [3H]SCH-23390 binding to rat Dopamine receptor D1	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		2286	9957	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		4927	9957	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		7282	9957	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		CHEMBL643	9957	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		DB01069	9957	51	None	-30	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	3	0	3	4.2	CN(C(CN1c2ccccc2Sc2c1cccc2)C)C	None
		2600	10551	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		2608	10551	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		5405	10551	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		CHEMBL17157	10551	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		DB00342	10551	74	None	-7	13	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	471	8	2	3	6.4	OC(c1ccc(cc1)C(C)(C)C)CCCN1CCC(CC1)C(c1ccccc1)(c1ccccc1)O	None
		6917970	10463	61	3H-SCH23390	-1	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		8370	10463	61	3H-SCH23390	-1	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		CHEMBL487387	10463	61	3H-SCH23390	-1	33	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	327	2	2	5	2.8	COc1cc2CCN3[C@H](c2cc1O)Cc1c(C3)c(OC)c(cc1)O	None
		2284	9956	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	9956	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	9956	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	9956	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	9956	33	None	-36	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		10531	8202	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		121	8202	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		888	8202	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		CHEMBL1732	8202	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		DB00320	8202	21	None	-218	24	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	583	4	3	6	2.1	CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O	None
		3117	214620	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		CHEMBL964	214620	103	None	-2	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	296	4	0	4	3.6	CCN(CC)C(=S)SSC(=S)N(CC)CC	None
		2389	10104	118	UNDEFINED	-346	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	UNDEFINED	-346	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	UNDEFINED	-346	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	UNDEFINED	-346	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	UNDEFINED	-346	66	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		3947	213174	53	3H-SCH23390	-74	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		CHEMBL87708	213174	53	3H-SCH23390	-74	16	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	418	7	0	3	5.8	CN(CCCN1c2ccccc2CCc2ccccc21)CC(=O)c1ccc(Cl)cc1	None
		5	6927	72	3H-SCH23390	-16595	53	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-SCH23390	-16595	53	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-SCH23390	-16595	53	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-SCH23390	-16595	53	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		None	223013	0	3H-SCH23390	-6	6	Mouse	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
		None	223013	0	3H-SCH23390	-6	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	255	2	1	2	2.4	CCCN1CCCC2C1CC3=C(C2)NN=C3.Cl	None
		11954259	222758	0	3H-SCH23390	-169	43	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		681	8247	72	3H-SCH23390 High	-23	38	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-SCH23390 High	-23	38	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-SCH23390 High	-23	38	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-SCH23390 High	-23	38	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-SCH23390 High	-23	38	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		115237	62359	119	3H-SCH23390	-2511	54	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-SCH23390	-2511	54	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		3153	7085	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		932	7085	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		CHEMBL26736	7085	28	3H-SCH23390	-3019	8	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	None
		135398745	9688	112	UNDEFINED	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	UNDEFINED	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	UNDEFINED	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	UNDEFINED	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		31116	223062	0	3H-dopamine	-37	2	Bovine	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	609	5	3	6	2.6	CC(C)C1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		135398745	9688	112	3H-SCH233930	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH233930	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH233930	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH233930	-26	65	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	223516	0	UNDEFINED	-	1	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	433	4	0	5	4.2	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)OC)Br	None
		2389	10104	118	3H-SCH23390	-489	66	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-489	66	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-489	66	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-489	66	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-489	66	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		None	224050	0	UNDEFINED	-	1	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	323	2	0	4	3.4	CC(=O)OC1=CC=CC2=C1C3=CC(=CC4=C3C(C2)N(CC4)C)OC	None
		135398737	7745	93	UNDEFINED	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	UNDEFINED	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	UNDEFINED	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	UNDEFINED	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	UNDEFINED	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		5568	204279	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		66069	204279	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		CHEMBL1201102	204279	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		CHEMBL570	204279	29	3H-dopamine	-251	5	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	352	4	0	3	5.3	CN(C)CCCN1c2ccccc2Sc2ccc(C(F)(F)F)cc21	None
		16362	9899	71	3H-dopamine	-30199	29	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	3H-dopamine	-30199	29	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	3H-dopamine	-30199	29	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	3H-dopamine	-30199	29	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	3H-dopamine	-30199	29	Bovine	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		185	10778	60	3H-SCH23390	-6606	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	10778	60	3H-SCH23390	-6606	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	10778	60	3H-SCH23390	-6606	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	10778	60	3H-SCH23390	-6606	37	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		135398737	7745	93	3H-SCH23390	-44	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-44	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-44	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-44	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-44	90	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		1613	9127	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	3H-SCH23390	-5	44	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		11954259	222758	0	3H-dopamine	-7762	43	Bovine	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	443	5	0	5	3.5	CN1CCN(CC1)CCC=C2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N(C)C	None
		None	223346	0	UNDEFINED	-549	6	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	158	7	0	2	2.6	CCCCN(CCCC)N=O	None
		3294	8787	111	3H-SCH23390	-794	44	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	3H-SCH23390	-794	44	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	3H-SCH23390	-794	44	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	3H-SCH23390	-794	44	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	3H-SCH23390	-794	44	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2995	211184	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	211184	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	211184	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		2995	211184	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	211184	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	211184	53	3H-SCH23390	-23	23	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		135398737	7745	93	3H-SCH23390	-22	90	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-22	90	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-22	90	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-22	90	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-22	90	Mouse	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2389	10104	118	3H-SCH23390	-346	66	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-346	66	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-346	66	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-346	66	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-346	66	Rat	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		11654739	183627	0	UNDEFINED	-20417	4	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	None
		CHEMBL461236	183627	0	UNDEFINED	-20417	4	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	422	7	1	4	4.2	O=C(NCCCCN1CCN(c2cccc(Cl)c2)CC1)c1cc2ccccc2cn1	None
		1242	10385	27	125I-SCH 23982	-5	17	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	125I-SCH 23982	-5	17	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	125I-SCH 23982	-5	17	Human	7.3	pKi	=	7.3	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		24949693	189083	0	UNDEFINED	-7244	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
		CHEMBL478413	189083	0	UNDEFINED	-7244	3	Rat	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	370	6	0	6	4.0	c1ccc(N2CCN(CCCSc3nc4ccccc4s3)CC2)nc1	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2389	10104	118	3H-SCH233930	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH233930	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH233930	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH233930	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH233930	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2470	10425	50	3H-SCH23390	-4168	58	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-SCH23390	-4168	58	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-SCH23390	-4168	58	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-SCH23390	-4168	58	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-SCH23390	-4168	58	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		1353	8692	93	3H-SCH23390	-38	85	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-38	85	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-38	85	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-38	85	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-38	85	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	9688	112	3H-SCH23390	-26	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-26	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-26	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-26	65	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		2389	10104	118	UNDEFINED	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	UNDEFINED	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	UNDEFINED	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	UNDEFINED	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	UNDEFINED	-489	66	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		100	10577	58	3H-SCH23390	-16	54	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-SCH23390	-16	54	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-SCH23390	-16	54	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-SCH23390	-16	54	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-SCH23390	-16	54	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		None	223106	0	3H-SCH23390	16	27	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	536	11	1	4	9.0	CC(C)C(=O)C12C(=O)C(=C(C(C1=O)(CC(C2(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)O)CC=C(C)C	None
		135	9310	43	None	-91	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		1796	9310	43	None	-91	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		4184	9310	43	None	-91	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		CHEMBL6437	9310	43	None	-91	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		DB06148	9310	43	None	-91	56	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	264	0	0	2	3.1	CN1CCN2C(C1)c1ccccc1Cc1c2cccc1	None
		None	223513	0	UNDEFINED	-	1	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	467	3	1	5	3.8	CN1CCC2=C(C(=C(C3=C2C1CC4=CC(=C(C=C43)OC)OC)OC)O)I	None
		11954224	222732	0	None	-3467	59	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	581	4	3	6	2.0	CC1(C(=O)N2C(C(=O)N3CCCC3C2(O1)O)CC4=CC=CC=C4)NC(=O)C5CN(C6CC7=CNC8=CC=CC(=C78)C6=C5)C	None
		242	7258	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	None	-281	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		26987	7736	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		6063	7736	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		671	7736	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		CHEMBL1626	7736	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		DB00283	7736	33	None	-245	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	343	6	0	2	5.1	Clc1ccc(cc1)[C@@](c1ccccc1)(OCC[C@H]1CCCN1C)C	None
		2585	7590	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		522	7590	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		551	7590	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		CHEMBL723	7590	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		DB01136	7590	103	None	-112	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	406	10	3	5	3.7	COc1ccccc1OCCNCC(COc1cccc2c1c1ccccc1[nH]2)O	None
		31101	7516	40	None	-436	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	7516	40	None	-436	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	7516	40	None	-436	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	7516	40	None	-436	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	7516	40	None	-436	35	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		6603820	102549	19	3H-SCH23390	1	12	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	3H-SCH23390	1	12	Rat	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		3191	109635	97	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		CHEMBL305660	109635	97	None	-12	25	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	469	9	0	3	7.2	CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1	None
		107715	207724	22	None	-144	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL1255837	207724	22	None	-144	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		CHEMBL601773	207724	22	None	-144	20	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	611	5	3	6	2.7	CC(C)[C@@]1(NC(=O)[C@@H]2C[C@@H]3c4cccc5[nH]cc(c45)C[C@H]3N(C)C2)O[C@@]2(O)[C@@H]3CCCN3C(=O)[C@H](Cc3ccccc3)N2C1=O	None
		3168	16034	92	None	-89	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		CHEMBL1108	16034	92	None	-89	22	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		150	9287	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		1764	9287	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		8226	9287	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		CHEMBL1201356	9287	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		DB00353	9287	21	None	-43	16	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	339	4	3	3	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CO	None
		2407	10145	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		59227	10145	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		941	10145	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		CHEMBL1303	10145	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		DB05271	10145	76	None	-60	7	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390Binding affinity of compound for Dopamine receptor D1 using [3H]-SCH- 23390	Drug Central	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	None
		5440	35497	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
		CHEMBL1378	35497	37	None	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	399	6	0	5	5.0	CCSc1ccc2c(c1)N(CCCN1CCN(C)CC1)c1ccccc1S2	None
		4011	89183	49	None	-64	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		CHEMBL21731	89183	49	None	-64	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	4	1	1	4.2	CNCCCC12CCC(c3ccccc31)c1ccccc12	None
		134	9292	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1775	9292	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		9681	9292	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		CHEMBL1065	9292	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		DB00247	9292	24	None	-263	67	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	353	4	2	4	1.9	CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO	None
		1530	8963	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		3827	8963	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		7206	8963	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		CHEMBL534	8963	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		DB00920	8963	50	None	-53	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	309	0	0	3	4.0	CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1	None
		68663	34055	23	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	None
		CHEMBL136711	34055	23	None	-6	4	Rat	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	391	5	1	3	4.0	O=C(CCCN1CCN2Cc3[nH]c4ccccc4c3CC2C1)c1ccc(F)cc1	None
		135398737	7745	93	None	-204	90	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-204	90	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-204	90	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-204	90	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-204	90	Bovine	8.2	pKi	=	8.2	Binding	Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390Binding affinity against bovine dopamine receptor D1 using radioligand [3H]-SCH- 23390	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		135398737	7745	93	None	-37	90	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-37	90	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-37	90	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-37	90	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-37	90	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membraneDisplacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		2337	10030	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	None	-53	62	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		7077	73733	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
		CHEMBL186720	73733	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
		CHEMBL3925724	73733	27	None	-3	5	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant dopamine receptor D1Binding affinity for human recombinant dopamine receptor D1	Drug Central	255	6	0	2	3.2	CN(C)CCOc1ccccc1Cc1ccccc1	None
		2105	9828	37	None	-123	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		47811	9828	37	None	-123	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		48	9828	37	None	-123	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		CHEMBL531	9828	37	None	-123	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		DB01186	9828	37	None	-123	32	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	None
		2470	10425	50	None	-4168	58	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	None	-4168	58	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	None	-4168	58	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	None	-4168	58	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	None	-4168	58	Human	8.2	pKi	=	8.2	Binding	Binding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkeyBinding affinity against dopamine receptor D1 by using [3H]-SCH- 23390 as radioligand in caudate-putamen of monkey	Drug Central	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3561	25849	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		CHEMBL1289	25849	39	None	-1	11	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	360	2	0	1	4.4	Clc1cc(Cl)c(OCC#CI)cc1Cl	None
		1971	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		2404	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		4543	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		CHEMBL445	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		DB00540	9641	38	None	-8	30	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	263	3	1	1	3.8	CNCCC=C1c2ccccc2CCc2c1cccc2	None
		5462328	224516	0	None	1	2	Rat	8.2	pKi	=	8.2	Binding	Dopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranesDopamine receptor D1 affinity was tested in vitro against corpus striatum from rat brain membranes	Drug Central	369	2	0	6	2.0	CN1CC[C@]23[C@H]4OC5=C(OC(C)=O)C=CC(C[C@@H]1[C@@H]2C=C[C@@H]4OC(C)=O)=C35	None
		2398	7741	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		2801	7741	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		701	7741	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		CHEMBL415	7741	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		DB01242	7741	62	None	-11	29	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	314	4	0	2	4.5	CN(CCCN1c2ccccc2CCc2c1cc(Cl)cc2)C	None
		3294	8787	111	None	-56	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		71360	8787	111	None	-56	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		87	8787	111	None	-56	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		CHEMBL14376	8787	111	None	-56	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		DB04946	8787	111	None	-56	44	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	426	8	0	6	4.8	COc1cc(ccc1OCCCN1CCC(CC1)c1noc2c1ccc(c2)F)C(=O)C	None
		2435	10362	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	None	-72	48	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards human Dopamine receptor D1Binding affinity towards human Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		134551	7146	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		271	7146	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		885	7146	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		CHEMBL1403281	7146	27	None	-28	21	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		37	7565	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		460	7565	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		54746	7565	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		CHEMBL1201087	7565	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		DB00248	7565	60	None	-14	17	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	None
		1524	8962	96	None	-79	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		197	8962	96	None	-79	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		3822	8962	96	None	-79	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		88	8962	96	None	-79	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		CHEMBL51	8962	96	None	-79	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		DB12465	8962	96	None	-79	51	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	None
		191	7191	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		201	7191	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		2170	7191	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		CHEMBL1113	7191	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		DB00543	7191	98	None	-26	29	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	313	0	1	4	3.4	Clc1ccc2c(c1)C(=Nc1c(O2)cccc1)N1CCNCC1	None
		1621	9207	17	None	-112	44	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		17	9207	17	None	-112	44	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		5761	9207	17	None	-112	44	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL263881	9207	17	None	-112	44	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB04829	9207	17	None	-112	44	Mouse	8.2	pKi	=	8.2	Binding	Binding affinities towards Dopamine receptor D1Binding affinities towards Dopamine receptor D1	Drug Central	323	3	1	2	2.9	CCN(C(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		11978813	7508	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		5014	7508	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		7672	7508	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		CHEMBL2105760	7508	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		DB09128	7508	79	None	-8	24	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	433	7	1	5	4.7	O=c1ccc2c([nH]1)cc(cc2)OCCCCN1CCN(CC1)c1cccc2c1ccs2	None
		681	8247	72	None	-97	38	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	None	-97	38	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	None	-97	38	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	None	-97	38	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	None	-97	38	Rat	8.2	pKi	=	8.2	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		33630	185736	99	None	-5	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		CHEMBL47050	185736	99	None	-5	28	Human	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assayDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293T cells by radioligand binding assay	Drug Central	523	7	1	2	7.5	OC1(c2ccc(Cl)c(C(F)(F)F)c2)CCN(CCCC(c2ccc(F)cc2)c2ccc(F)cc2)CC1	None
		52919	21222	48	None	-15	4	Pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL1200986	21222	48	None	-15	4	Pig	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	529	15	0	4	8.1	CCCCCCCCCC(=O)OC1(c2ccc(Cl)cc2)CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		135398737	7745	93	None	-44	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-44	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-44	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-44	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-44	90	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		277	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		2913	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		765	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		CHEMBL516	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		DB00434	8083	62	None	-33	50	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	287	0	0	1	4.7	CN1CCC(=C2c3ccccc3C=Cc3c2cccc3)CC1	None
		1712	9270	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		4078	9270	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		7227	9270	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		CHEMBL1088	9270	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		DB00933	9270	43	None	-6	22	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	None
		2389	10104	118	3H-SCH23390	-489	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-489	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-489	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-489	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-489	66	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2448	106099	70	3H-dopamine	-426	18	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	106099	70	3H-dopamine	-426	18	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		1042	8362	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		148	8362	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		443884	8362	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		CHEMBL119443	8362	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		DB01253	8362	23	3H-dopamine	-97	17	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	325	3	3	3	1.5	OC[C@@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C	None
		None	223555	0	UNDEFINED	-2	4	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	251	0	1	2	3.1	CN1CCC2=CC=CC3=C2C1CC4=C3C(=CC=C4)O	None
		10265732	101624	0	UNDEFINED	2	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		CHEMBL253738	101624	0	UNDEFINED	2	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	0	2	3	2.8	CN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		2389	10104	118	3H-SCH23390	-346	66	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-346	66	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-346	66	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-346	66	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-346	66	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		185	10778	60	3H-SCH23390	-6606	37	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		5311271	10778	60	3H-SCH23390	-6606	37	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		CHEMBL74355	10778	60	3H-SCH23390	-6606	37	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		DB16351	10778	60	3H-SCH23390	-6606	37	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	373	7	1	4	3.8	COc1cccc(c1OC)[C@@H](C1CCN(CC1)CCc1ccc(cc1)F)O	None
		44448063	162024	0	UNDEFINED	3	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
		CHEMBL402736	162024	0	UNDEFINED	3	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	1	1	2	3.0	COc1cc2c3c(c1)Cc1ccccc1CC3NCC2	None
		68617	212306	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL1709	212306	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		CHEMBL809	212306	62	3H-SCH23390	-912	26	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	305	2	1	1	5.2	CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c2ccccc21	None
		1242	10385	27	125I-SCH 23982	1	17	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	125I-SCH 23982	1	17	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	125I-SCH 23982	1	17	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		1588	9105	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	3H-SCH23390	-131	44	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		10355510	162441	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		CHEMBL404865	162441	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	265	0	1	2	3.1	CN1CCc2cc(O)cc3c2C1Cc1ccccc1C3	None
		None	223509	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	325	3	2	4	3.6	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=C(C=C4)O)O	None
		1353	8692	93	3H-dopamine	-512	85	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-dopamine	-512	85	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-dopamine	-512	85	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-dopamine	-512	85	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-dopamine	-512	85	Bovine	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		44448061	101622	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
		CHEMBL253736	101622	0	UNDEFINED	1	2	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	293	2	0	2	3.8	CCN1CCc2cc(OC)cc3c2C1Cc1ccccc1C3	None
		None	224146	0	UNDEFINED	-	1	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	407	3	2	3	5.7	CCCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5.Cl	None
		20840341	222956	0	3H-dopamine	-75	4	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	451	5	1	3	6.2	C1CN(CCC1CCO)CCC=C2C3=C(C=C(C=C3)F)SC4=C2C=C(C=C4)C(F)(F)F	None
		115237	62359	119	3H-SCH23390	-2511	54	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	3H-SCH23390	-2511	54	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		31101	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		25058166	222739	0	3H-SCH23390	-144	26	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-SCH23390	-144	26	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		16362	9899	71	3H-dopamine	-30199	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	3H-dopamine	-30199	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	3H-dopamine	-30199	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	3H-dopamine	-30199	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	3H-dopamine	-30199	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		10660476	54147	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
		CHEMBL154468	54147	0	UNDEFINED	-	1	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	281	1	1	3	3.7	CCN1CCc2cccc3c2C1Cc1cc(O)ccc1O3	None
		134551	7146	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		271	7146	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		885	7146	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		CHEMBL1403281	7146	27	3H-dopamine	-53	21	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	575	5	3	6	2.4	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)C(C)C)O)C	None
		135398745	9688	112	UNDEFINED	-23	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	UNDEFINED	-23	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	UNDEFINED	-23	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	UNDEFINED	-23	65	Rat	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		31101	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		35	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		403	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		CHEMBL493	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		DB01200	7516	40	3H-SCH23390	-436	35	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	None
		127708	119298	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		CHEMBL329904	119298	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		228	7233	28	None	-4	23	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	7233	28	None	-4	23	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	7233	28	None	-4	23	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	7233	28	None	-4	23	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	7233	28	None	-4	23	Mouse	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cellsDisplacement of [3H]SCH23390 from dopamine D1 receptor in mouse Ltk- fibroblast cells	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		2448	106099	70	None	-5	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		CHEMBL28218	106099	70	None	-5	18	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	419	6	1	3	4.5	O=C(CCCN1CCC(O)(c2ccc(Br)cc2)CC1)c1ccc(F)cc1	None
		1212	8443	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	3H-SCH23390	-51	65	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1353	8692	93	None	-30	85	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	None	-30	85	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	None	-30	85	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	None	-30	85	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	None	-30	85	Pig	8.2	pKi	=	8.2	Binding	Displacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenatesDisplacement of [3H]SCH23390 from D1 receptor from porcine cerebral cortex homogenates	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		180	7189	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	7189	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	7189	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	7189	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	7189	56	None	-109	40	Human	8.2	pKi	=	8.2	Binding	NoneNone	Drug Central	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1588	9105	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		28864	9105	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		43	9105	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL157138	9105	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB00589	9105	27	None	-131	44	Human	8.2	pKi	=	8.2	Binding	Affinity towards Dopamine receptor D1Affinity towards Dopamine receptor D1	Drug Central	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	None
		2274	9947	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	9947	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	9947	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	9947	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	9947	58	None	-16	31	Human	8.2	pKi	=	8.2	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		2726	7706	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	None	-36	72	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		25058166	222739	0	3H-dopamine	-6	26	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-dopamine	-6	26	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		1613	9127	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		205	9127	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		3964	9127	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		CHEMBL831	9127	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		DB00408	9127	53	None	-5	44	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	327	0	0	4	3.8	CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2	None
		228	7233	28	None	-30	23	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	7233	28	None	-30	23	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	7233	28	None	-30	23	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	7233	28	None	-30	23	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	7233	28	None	-30	23	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		212	10578	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		2639	10578	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		941651	10578	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		CHEMBL1201	10578	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		DB01623	10578	47	None	-6	25	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	443	5	0	5	3.5	CN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)S(=O)(=O)N(C)C	None
		135398737	7745	93	None	-83	90	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	None	-83	90	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	None	-83	90	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	None	-83	90	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	None	-83	90	Rat	8.1	pKi	=	8.1	Binding	Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandAffinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligand	Drug Central	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		21302490	119582	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
		CHEMBL3233142	119582	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
		CHEMBL3306803	119582	32	None	-8	9	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	393	5	0	4	3.9	CN1CCN2c3c(cccc31)[C@@H]1CN(CCCC(=O)c3ccc(F)cc3)CC[C@@H]12	None
		115237	62359	119	None	-74	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		CHEMBL1621	62359	119	None	-74	54	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	426	4	1	7	3.1	Cc1nc2n(c(=O)c1CCN1CCC(c3noc4cc(F)ccc34)CC1)CCCC2O	None
		135398745	9688	112	None	-26	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	None	-26	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	None	-26	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	None	-26	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		133	9274	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		1723	9274	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		28693	9274	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		CHEMBL19215	9274	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		DB13520	9274	52	None	-30	43	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	403	4	1	4	4.1	O=C(OCc1ccccc1)NC[C@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)cn3C	None
		2726	7706	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	None	-18	72	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		103	10925	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	None	-28	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		1212	8443	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		204	8443	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		3372	8443	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL726	8443	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00623	8443	50	None	-51	65	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2389	10104	118	None	-346	66	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	None	-346	66	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	None	-346	66	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	None	-346	66	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	None	-346	66	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		2389	10104	118	None	-489	66	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	None	-489	66	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	None	-489	66	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	None	-489	66	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	None	-489	66	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		3389	224490	0	None	-1	26	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	549	12	0	6	6.8	CCCCCCC(=O)OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	None
		1353	8692	93	None	-74	85	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	None	-74	85	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	None	-74	85	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	None	-74	85	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	None	-74	85	Rat	8.1	pKi	=	8.1	Binding	Affinity for Dopamine receptor D1Affinity for Dopamine receptor D1	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		135398745	9688	112	None	-23	65	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	None	-23	65	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	None	-23	65	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	None	-23	65	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		11976	7707	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		667467	7707	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		CHEMBL908	7707	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		DB01239	7707	59	None	-12	24	Human	8.1	pKi	=	8.1	Binding	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cellsDisplacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK cells	Drug Central	315	3	0	2	5.2	CN(C)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)Cl	None
		5281878	8441	35	None	-34	16	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	None	-34	16	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	None	-34	16	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	None	-34	16	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	None	-34	16	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	None	-34	16	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	None	-34	16	Bovine	8.1	pKi	=	8.1	Binding	Binding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determinedBinding affinity of compound towards Dopamine receptor D1 using [3H]SCH-23390 (0.5 nM) ligand in striatum bovine was determined	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		6761	74574	19	None	-5	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL1909072	74574	19	None	-5	18	Human	8.1	pKi	=	8.1	Binding	DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)DRUGMATRIX: Dopamine D1 radioligand binding (ligand: [3H] SCH-23390)	Drug Central	401	5	1	4	4.5	NC(=O)C1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	None
		1353	8692	93	None	-38	85	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	None	-38	85	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	None	-38	85	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	None	-38	85	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	None	-38	85	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		16351	109507	47	None	-4	6	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL304902	109507	47	None	-4	6	Rat	8.1	pKi	=	8.1	Binding	In vitro binding affinity against Dopamine receptor D1 in rat striatal tissueIn vitro binding affinity against Dopamine receptor D1 in rat striatal tissue	Drug Central	343	0	0	4	4.1	CN1CCN(C2=Nc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		2435	10362	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		60149	10362	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		98	10362	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		CHEMBL12713	10362	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		DB06144	10362	83	None	-43	48	Rat	8.1	pKi	=	8.1	Binding	Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1Ability to displace [3H]-SCH- 23390 (0.2 nM) from corpus striatum of rat Dopamine receptor D1	Drug Central	440	5	1	3	4.6	Clc1ccc2c(c1)c(cn2c1ccc(cc1)F)C1CCN(CC1)CCN1CCNC1=O	None
		37459	7533	13	3H-dopamine	-53	24	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-dopamine	-53	24	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-dopamine	-53	24	Bovine	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		127708	119298	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		CHEMBL329904	119298	7	UNDEFINED	-22	5	Rat	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	279	2	1	2	3.9	CCCN1CCc2cccc3c2C1Cc1cccc(O)c1-3	None
		7153	104796	77	3H-SCH23390	-371	33	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		CHEMBL272942	104796	77	3H-SCH23390	-371	33	Human	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	214	3	1	2	2.5	Cc1cc(Cl)ccc1OC(C)C(=O)O	None
		103	10925	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-SCH23390	-28	53	Human	7.2	pKi	=	7.2	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2284	9956	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		4926	9956	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		7281	9956	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		CHEMBL564	9956	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		DB00420	9956	33	3H-dopamine	-3019	29	Bovine	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	284	4	0	3	4.2	CN(CCCN1c2ccccc2Sc2c1cccc2)C	None
		2337	10030	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		50	10030	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		5002	10030	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		CHEMBL716	10030	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		DB01224	10030	77	3H-SCH23390	-53	62	Human	6.2	pKi	=	6.2	Binding	NoneNone	PDSP KiDatabase	383	5	1	6	2.9	OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2c1cccc2	None
		25186023	194523	0	UNDEFINED	-50118	4	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	None
		CHEMBL495572	194523	0	UNDEFINED	-50118	4	Rat	5.2	pKi	=	5.2	Binding	NoneNone	PDSP KiDatabase	443	8	0	4	5.9	Clc1cccc(N2CCN(CCCCCOc3cc4ccccc4cn3)CC2)c1Cl	None
		25058166	222739	0	UNDEFINED	-144	26	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	UNDEFINED	-144	26	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		44448067	162308	0	UNDEFINED	-	1	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	None
		CHEMBL404240	162308	0	UNDEFINED	-	1	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	309	2	0	3	3.4	COc1cc2c3c(c1OC)Cc1ccccc1CC3N(C)CC2	None
		5281878	8441	35	3H-SCH23390	-34	16	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-34	16	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-34	16	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-34	16	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-34	16	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-34	16	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-34	16	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2726	7706	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-SCH23390	-36	72	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		1241	106955	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		CHEMBL288090	106955	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		CHEMBL552611	106955	24	3H-SCH23390	-2	8	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	295	3	2	3	3.3	C=CCN1CCc2cc(O)c(O)cc2C(c2ccccc2)C1	None
		30137	9652	0	UNDEFINED	-3981	9	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		8594	9652	0	UNDEFINED	-3981	9	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		934	9652	0	UNDEFINED	-3981	9	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	None
		2726	7706	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-SCH23390	-18	72	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		214	10632	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		2740	10632	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5566	10632	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		66064	10632	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL422	10632	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00831	10632	58	3H-dopamine	-891	30	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	407	4	0	4	4.9	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5567	49576	27	3H-dopamine	-812	8	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
		CHEMBL15023	49576	27	3H-dopamine	-812	8	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	409	6	1	3	4.8	O=C(CCCN1CCC(O)(c2cccc(C(F)(F)F)c2)CC1)c1ccc(F)cc1	None
		2389	10104	118	3H-SCH23390	-346	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		5073	10104	118	3H-SCH23390	-346	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		96	10104	118	3H-SCH23390	-346	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		CHEMBL85	10104	118	3H-SCH23390	-346	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		DB00734	10104	118	3H-SCH23390	-346	66	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	410	4	0	6	3.6	Fc1ccc2c(c1)onc2C1CCN(CC1)CCc1c(C)nc2n(c1=O)CCCC2	None
		100	10577	58	3H-SCH23390	-309	54	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-SCH23390	-309	54	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-SCH23390	-309	54	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-SCH23390	-309	54	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-SCH23390	-309	54	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		None	223917	0	UNDEFINED	-199	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	359	1	3	4	4.2	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O	None
		1353	8692	93	3H-SCH23390	-52	85	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-52	85	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-52	85	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-52	85	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-52	85	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	223194	0	3H-SCH23390	-676	5	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	453	8	1	4	4.6	COC1=CC=CC=C1N2CCN(CC2)CCCCNC(=O)C3=CC4=CC=CC=C4C=C3.Cl	None
		16362	9899	71	3H-dopamine	-30199	29	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2172	9899	71	3H-dopamine	-30199	29	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		90	9899	71	3H-dopamine	-30199	29	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		CHEMBL1423	9899	71	3H-dopamine	-30199	29	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		DB01100	9899	71	3H-dopamine	-30199	29	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	461	7	1	3	5.9	Fc1ccc(cc1)C(c1ccc(cc1)F)CCCN1CCC(CC1)n1c(=O)[nH]c2c1cccc2	None
		2470	10425	50	3H-SCH23390	-31622	58	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-SCH23390	-31622	58	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-SCH23390	-31622	58	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-SCH23390	-31622	58	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-SCH23390	-31622	58	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		681	8247	72	3H-SCH23390	-1548	38	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	3H-SCH23390	-1548	38	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	3H-SCH23390	-1548	38	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	3H-SCH23390	-1548	38	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	3H-SCH23390	-1548	38	Pig	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		None	223737	0	UNDEFINED	8	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	280	1	1	3	3.0	CN1CCC2=C3C1CC4=C(C3=CC(=C2)OC)C(=CC=C4)N	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		2107	9829	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		4747	9829	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		9216	9829	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		CHEMBL251940	9829	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		DB01608	9829	50	None	-5	2	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	None
		25058166	222739	0	3H-dopamine	-6	26	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-dopamine	-6	26	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		2865	10915	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	None	-114	53	Human	8.1	pKi	=	8.1	Binding	Binding affinity against dopamine receptor D1Binding affinity against dopamine receptor D1	Drug Central	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		681	8247	72	None	-23	38	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	None	-23	38	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	None	-23	38	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	None	-23	38	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	None	-23	38	Bovine	8.1	pKi	=	8.1	Binding	Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390Binding Affinity was tested on High Affinity Site of Bovine Dopamine receptor D1. Tested for ability to displace the radioligand [3H]-SCH- 23390	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		228	7233	28	None	-35	23	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		33	7233	28	None	-35	23	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		6005	7233	28	None	-35	23	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		CHEMBL53	7233	28	None	-35	23	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		DB00714	7233	28	None	-35	23	Human	8.1	pKi	=	8.1	Binding	Binding affinity to dopamine D1 receptor high binding site by radioligand displacement assayBinding affinity to dopamine D1 receptor high binding site by radioligand displacement assay	Drug Central	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	None
		5281878	8441	35	None	-2	16	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	None	-2	16	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	None	-2	16	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	None	-2	16	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	None	-2	16	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	None	-2	16	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	None	-2	16	Human	8.1	pKi	=	8.1	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Drug Central	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		62865	8057	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		746	8057	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		84	8057	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		CHEMBL2104153	8057	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		DB09000	8057	0	None	-2	15	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	323	4	0	4	4.4	N#Cc1ccc2c(c1)N(CC(CN(C)C)C)c1c(S2)cccc1	None
		1153	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		12668023	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026874	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		30026875	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		3341	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		6603851	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		933	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		939	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		985	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1160786	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL1161520	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		CHEMBL588	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		DB00800	8409	58	None	-1	10	Rat	8.1	pKi	=	8.1	Binding	Displacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranesDisplacement of [3H]fenoldopam from Dopamine receptor D1 of rat striatum membranes	Drug Central	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	None
		25058166	222739	0	3H-dopamine	-6	26	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-dopamine	-6	26	Bovine	8.1	pKi	=	8.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		1238	209953	24	None	-5	16	Rat	8.1	pKi	=	8.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	Drug Central	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		CHEMBL64249	209953	24	None	-5	16	Rat	8.1	pKi	=	8.1	Binding	Half-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenateHalf-maximal inhibition of [3H]-SCH- 23390 binding to Dopamine receptor D1 in rat striatal homogenate	Drug Central	344	1	0	3	4.3	CN1CCN(C2Cc3ccccc3Sc3ccc(Cl)cc32)CC1	None
		46780481	114308	20	None	-29	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		9903970	114308	20	None	-29	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3187365	114308	20	None	-29	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		CHEMBL3544974	114308	20	None	-29	53	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	285	0	0	2	4.3	CN1CC2c3ccccc3Oc3ccc(Cl)cc3C2C1	None
		37459	7533	13	3H-dopamine	-53	24	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-dopamine	-53	24	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-dopamine	-53	24	Bovine	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		15139	205859	52	3H-dopamine	-794	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	356	7	0	4	3.6	COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		CHEMBL58792	205859	52	3H-dopamine	-794	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	356	7	0	4	3.6	COc1ccccc1N1CCN(CCCC(=O)c2ccc(F)cc2)CC1	None
		16219195	222910	0	3H-dopamine	1	5	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	325	1	1	5	2.9	CN1CCC2=CC3=C(C4=C2C1CC5=C4C(=C(C=C5)OC)O)OCO3	None
		None	223504	0	UNDEFINED	-	1	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	325	4	0	3	3.9	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)F)C(=CC=C4)OC=O	None
		5281878	8441	35	3H-dopamine	-34	16	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-dopamine	-34	16	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-dopamine	-34	16	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-dopamine	-34	16	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-dopamine	-34	16	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-dopamine	-34	16	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-dopamine	-34	16	Bovine	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		180	7189	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	7189	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	7189	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	7189	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	7189	56	3H-SCH23390	-158	40	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		1353	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		484	9633	51	3H-dopamine	-4	35	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		951	9633	51	3H-dopamine	-4	35	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		CHEMBL432	9633	51	3H-dopamine	-4	35	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	None
		2780	117306	36	3H-SCH23390	-630	10	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
		CHEMBL325109	117306	36	3H-SCH23390	-630	10	Mouse	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	373	5	2	4	3.3	COc1cc(N)c(Cl)cc1C(=O)NC1CCN(Cc2ccccc2)CC1	None
		1353	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-38	85	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		44448064	101649	0	UNDEFINED	1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		CHEMBL253947	101649	0	UNDEFINED	1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	295	1	2	3	3.2	CCN1CCc2cc(O)c(O)c3c2C1Cc1ccccc1C3	None
		1353	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-SCH23390	-74	85	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL146246	45052	0	3H-SCH23390	-2290	9	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	401	5	1	5	2.2	NS(=O)(=O)c1ccc(N2CCN(CCC3OCCc4ccccc43)CC2)cc1	None
		103	10925	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2875	10925	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		5736	10925	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL285802	10925	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB09225	10925	61	3H-SCH23390	-69	53	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	331	4	0	3	4.9	CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C	None
		2470	10425	50	3H-SCH23390	-51286	58	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		3300	10425	50	3H-SCH23390	-51286	58	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		5265	10425	50	3H-SCH23390	-51286	58	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		99	10425	50	3H-SCH23390	-51286	58	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		CHEMBL267930	10425	50	3H-SCH23390	-51286	58	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		279	8442	26	3H-SCH23390	-17	17	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		49381	8442	26	3H-SCH23390	-17	17	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		CHEMBL63756	8442	26	3H-SCH23390	-17	17	Mouse	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	309	0	0	3	3.1	CN1CCN(CC1)C1=Nc2cc(F)ccc2Cc2c1cccc2	None
		135398745	9688	112	3H-SCH23390	-23	65	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		47	9688	112	3H-SCH23390	-23	65	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		CHEMBL715	9688	112	3H-SCH23390	-23	65	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		DB00334	9688	112	3H-SCH23390	-23	65	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	312	1	1	5	1.7	CN1CCN(CC1)C1=c2cc(sc2=Nc2c(N1)cccc2)C	None
		44448060	162023	0	UNDEFINED	-1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	None
		CHEMBL402735	162023	0	UNDEFINED	-1	2	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	279	1	0	2	3.4	COc1cc2c3c(c1)Cc1ccccc1CC3N(C)CC2	None
		None	223912	0	UNDEFINED	-269	11	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	116	4	0	2	1.4	CCCCN(C)N=O	None
		25058166	222739	0	3H-SCH23390	-147	26	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		6852389	222739	0	3H-SCH23390	-147	26	Rat	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	267	0	2	3	2.9	CN1CCC2=CC=CC3=C2C1CC4=C3C(=C(C=C4)O)O	None
		135398737	7745	93	3H-SCH23390	-83	90	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	3H-SCH23390	-83	90	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	3H-SCH23390	-83	90	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	3H-SCH23390	-83	90	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	3H-SCH23390	-83	90	Rat	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		44591012	182359	0	UNDEFINED	-177	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	None
		CHEMBL457957	182359	0	UNDEFINED	-177	6	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	522	10	0	3	6.6	CN(CCC=C1c2ccccc2CCc2ccccc21)C(=O)Cc1ccc(OCCCN2CCCCC2)cc1	None
		None	223916	0	UNDEFINED	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	343	1	2	3	4.5	CN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=CC=C5	None
		3168	16034	92	3H-dopamine	-1318	22	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		CHEMBL1108	16034	92	3H-dopamine	-1318	22	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	379	6	1	4	3.7	O=C(CCCN1CC=C(n2c(=O)[nH]c3ccccc32)CC1)c1ccc(F)cc1	None
		180	7189	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		200	7189	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		2160	7189	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		CHEMBL629	7189	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		DB00321	7189	56	UNDEFINED	-109	40	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	277	3	0	1	4.2	CN(CCC=C1c2ccccc2CCc2c1cccc2)C	None
		135398737	7745	93	UNDEFINED	-44	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		38	7745	93	UNDEFINED	-44	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		722	7745	93	UNDEFINED	-44	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		CHEMBL42	7745	93	UNDEFINED	-44	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		DB00363	7745	93	UNDEFINED	-44	90	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	None
		100	10577	58	3H-SCH23390	-47	54	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		2637	10577	58	3H-SCH23390	-47	54	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		5452	10577	58	3H-SCH23390	-47	54	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		CHEMBL479	10577	58	3H-SCH23390	-47	54	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		DB00679	10577	58	3H-SCH23390	-47	54	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	None
		681	8247	72	None	-154	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		940	8247	72	None	-154	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		947	8247	72	None	-154	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		CHEMBL59	8247	72	None	-154	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		DB00988	8247	72	None	-154	38	Human	8.1	pKi	=	8.1	Binding	NoneNone	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
		242	7258	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		34	7258	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		60795	7258	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		CHEMBL1112	7258	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		DB01238	7258	124	None	-74	51	Rat	8.0	pKi	=	8.0	Binding	Displacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometryDisplacement of [3H]SCH23390 from dopamine D1 receptor in CRL:CD(SD)BR-COBS rat striatum by scintillation spectrometry	Drug Central	447	7	1	4	4.9	O=C1CCc2c(N1)cc(cc2)OCCCCN1CCN(CC1)c1cccc(c1Cl)Cl	None
		37459	7533	13	3H-SCH23390	-21	24	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		62	7533	13	3H-SCH23390	-21	24	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		CHEMBL8514	7533	13	3H-SCH23390	-21	24	Rhesus macaque	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	None
		2865	10915	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		59	10915	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		60854	10915	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		CHEMBL708	10915	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		DB00246	10915	73	UNDEFINED	-114	53	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	412	4	1	5	3.8	O=C1Nc2c(C1)cc(c(c2)Cl)CCN1CCN(CC1)c1nsc2c1cccc2	None
		6603820	102549	19	3H-SCH23390	1	12	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		CHEMBL25856	102549	19	3H-SCH23390	1	12	Rat	8.0	pKi	=	8.0	Binding	NoneNone	PDSP KiDatabase	267	0	3	3	2.6	Oc1cc2c(cc1O)[C@H]1c3ccccc3CN[C@@H]1CC2	None
		2726	7706	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	3H-dopamine	-186	72	Bovine	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		6852400	222716	0	3H-SCH23390	-22387	22	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		73759726	222716	0	3H-SCH23390	-22387	22	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	361	0	1	2	4.8	CC(C)(C)C1(CCN2CC3C4=CC=CC=C4CCC5=C3C(=CC=C5)C2C1)O	None
		None	222914	0	3H-KETANSERIN	-9332	23	Rat	5.1	pKi	=	5.1	Binding	NoneNone	PDSP KiDatabase	772	16	4	10	5.5	CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.CN(C)CCONC(=CC=C1C=CC(=O)C=C1)C2=CC=CC=C2F.C(=CC(=O)O)C(=O)O	None
		5281878	8441	35	3H-SCH23390	-11	16	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		5281881	8441	35	3H-SCH23390	-11	16	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		948	8441	35	3H-SCH23390	-11	16	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		968	8441	35	3H-SCH23390	-11	16	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL42055	8441	35	3H-SCH23390	-11	16	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		CHEMBL54661	8441	35	3H-SCH23390	-11	16	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		DB00875	8441	35	3H-SCH23390	-11	16	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	None
		1353	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		3559	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		86	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		CHEMBL54	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		DB00502	8692	93	3H-dopamine	-512	85	Bovine	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	None
		None	223510	0	UNDEFINED	-	1	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	311	2	3	4	3.3	CCCN1CCC2=C3C1CC4=C(C3=CC(=C2)O)C(=C(C=C4)O)O	None
		24949535	188338	0	UNDEFINED	-1122	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	None
		CHEMBL476722	188338	0	UNDEFINED	-1122	3	Rat	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	425	10	0	6	5.3	COc1ccccc1N1CCN(CCCCCCSc2nc3ccccc3o2)CC1	None
		5074	10105	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		97	10105	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		CHEMBL267777	10105	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		DB12693	10105	80	3H-SCH23390	-1621	30	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	477	5	0	5	5.5	Fc1ccc(cc1)C(=C1CCN(CC1)CCc1c(C)nc2n(c1=O)ccs2)c1ccc(cc1)F	None
		None	224147	0	UNDEFINED	-	1	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	423	3	3	4	5.4	CCCN1CCC2=CC(=CC3=C2C1CC4=C3C(=C(C=C4)O)O)C5=CC=C(C=C5)O.Cl	None
		2726	7706	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		621	7706	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		83	7706	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		CHEMBL71	7706	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		DB00477	7706	68	UNDEFINED	-36	72	Human	7.0	pKi	=	7.0	Binding	NoneNone	PDSP KiDatabase	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	None
		5	6927	72	3H-SCH23390	-23442	53	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		5202	6927	72	3H-SCH23390	-23442	53	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		CHEMBL39	6927	72	3H-SCH23390	-23442	53	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		DB08839	6927	72	3H-SCH23390	-23442	53	Human	5.0	pKi	=	5.0	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
		1242	10385	27	3H-SCH23390	-5	17	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		935	10385	27	3H-SCH23390	-5	17	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		CHEMBL286080	10385	27	3H-SCH23390	-5	17	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	None
		5281878	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		5281878	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		5281881	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		5281881	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		948	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		948	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		968	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		968	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		CHEMBL42055	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		CHEMBL42055	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		CHEMBL54661	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		CHEMBL54661	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		DB00875	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		DB00875	8441	35	None	-2	16	Human	7.7	pKi	=	7.7	Binding	Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.Note that this assay uses the <i>cis</i> form of the compound, whereas the approved drug is a racemic mixture of <i>cis</i> and <i>trans</i> molecules.	Guide to Pharmacology	434	5	1	4	4.6	OCCN1CCN(CC1)CC/C=C\1/c2ccccc2Sc2c1cc(cc2)C(F)(F)F	7525564
		681	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		681	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		940	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		940	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		947	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		947	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		CHEMBL59	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		CHEMBL59	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		DB00988	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	1826762
		DB00988	8247	72	None	-154	38	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	7525564
		5	6927	72	None	-23442	53	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
		5202	6927	72	None	-23442	53	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
		CHEMBL39	6927	72	None	-23442	53	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
		DB08839	6927	72	None	-23442	53	Human	5.0	pKi	=	5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	1826762
		1153	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		12668023	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		30026874	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		30026875	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		3341	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		6603851	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		933	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		939	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		985	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL1160786	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL1161520	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL588	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		DB00800	8409	58	None	-32	10	Human	5.7	pKi	=	5.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		1242	10385	27	None	-5	17	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
		1242	10385	27	None	-5	17	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
		935	10385	27	None	-5	17	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
		935	10385	27	None	-5	17	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
		CHEMBL286080	10385	27	None	-5	17	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	1826762
		CHEMBL286080	10385	27	None	-5	17	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	255	1	3	3	2.4	Oc1cc2CCNCC(c2cc1O)c1ccccc1	7525564
		1712	9270	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		4078	9270	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		7227	9270	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		CHEMBL1088	9270	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		DB00933	9270	43	None	-6	22	Human	7.0	pKi	=	7.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	386	4	0	4	4.9	CN1CCCCC1CCN1c2ccccc2Sc2c1cc(cc2)S(=O)C	15357957
		2274	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		4917	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		7279	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		CHEMBL728	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		DB00433	9947	58	None	-16	31	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	373	4	0	4	4.6	CN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(Cl)cc2	None
		1153	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		12668023	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		30026874	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		30026875	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		3341	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		6603851	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		933	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		939	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		985	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		CHEMBL1160786	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		CHEMBL1161520	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		CHEMBL588	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		DB00800	8409	58	None	-32	10	Human	7.2	pKi	=	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	7525564
		1153	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		12668023	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		30026874	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		30026875	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		3341	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		6603851	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		933	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		939	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		985	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL1160786	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL1161520	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		CHEMBL588	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		DB00800	8409	58	None	-32	10	Human	7.6	pKi	=	7.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	305	1	4	4	2.7	Oc1ccc(cc1)C1CNCCc2c1cc(O)c(c2Cl)O	1826762
		1353	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		1353	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		3559	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		3559	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		86	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		86	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		CHEMBL54	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		CHEMBL54	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		DB00502	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	1826762
		DB00502	8692	93	None	-38	85	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	375	6	1	3	4.4	Fc1ccc(cc1)C(=O)CCCN1CCC(CC1)(O)c1ccc(cc1)Cl	18308814
		5311070	8199	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
		9267	8199	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
		CHEMBL4280145	8199	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
		DB12890	8199	0	None	-	1	Rat	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	3	3	2.6	Oc1cc2CC[C@H]3[C@H](c2cc1O)c1ccccc1CN3	2572425
		2107	9829	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		4747	9829	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		9216	9829	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		CHEMBL251940	9829	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		DB01608	9829	50	None	-5	2	Human	8.0	pKi	=	8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	365	4	1	5	4.0	N#Cc1ccc2c(c1)N(CCCN1CCC(CC1)O)c1c(S2)cccc1	7918347
		13372	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	30525590
		86764100	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	30525590
		CHEMBL3697617	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	30525590
		DB14899	10531	30	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	391	3	1	5	3.6	CC1=C(C=CC(=C1)OC2=C(C=CC=N2)C(F)(F)F)C3=C(C(=O)NC(=O)N3C)C	30525590
		107930	8311	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
		3304	8311	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
		CHEMBL298406	8311	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
		DB12273	8311	26	None	1	6	Human	8.3	pKi	=	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	313	0	1	2	4.0	CN1CCc2c([C@@H]3[C@@H]1CCc1c3cccc1)cc(c(c2)Cl)O	7862709
		5018	10322	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
		5018	10322	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
		943	10322	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
		943	10322	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
		946	10322	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
		946	10322	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
		CHEMBL13668	10322	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	1826762
		CHEMBL13668	10322	13	None	2	10	Human	8.5	pKi	=	8.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	287	1	1	2	3.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Cl)O	7525564
		1218	10388	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
		938	10388	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
		CHEMBL353335	10388	30	None	11	8	Rat	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	289	1	3	3	3.0	Oc1c(O)cc2c(c1Cl)CCNCC2c1ccccc1	1973652
		6603703	6996	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
		9637	6996	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
		CHEMBL291143	6996	10	None	-1	5	Human	8.7	pKi	=	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	329	2	3	4	3.3	NC[C@@H]1O[C@@H](Cc2c1ccc(c2O)O)C12CC3CC(C2)CC(C1)C3	17067639
		1243	10390	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
		944	10390	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
		CHEMBL324017	10390	34	None	3	5	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	331	1	1	2	3.8	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O	1826762
		2995	211184	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL1696	211184	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		CHEMBL72	211184	53	None	-23	23	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	266	4	1	2	3.5	CNCCCN1c2ccccc2CCc2ccccc21	None
		5770	211837	82	None	-2	7	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
		CHEMBL772	211837	82	None	-2	7	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	608	8	1	10	4.2	COC(=O)[C@H]1[C@H]2C[C@@H]3c4[nH]c5cc(OC)ccc5c4CCN3C[C@H]2C[C@@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)[C@@H]1OC	None
		213	10625	55	None	-12	43	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2717	10625	55	None	-12	43	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		5533	10625	55	None	-12	43	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		CHEMBL621	10625	55	None	-12	43	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		DB00656	10625	55	None	-12	43	Human	8.3	pKi	None	8.3	Binding	NoneNone	Drug Central	371	5	0	6	2.4	Clc1cccc(c1)N1CCN(CC1)CCCn1nc2n(c1=O)cccc2	None
		2601	10552	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		443951	10552	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		56	10552	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		CHEMBL73151	10552	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		DB13399	10552	33	None	-16	21	Human	8.1	pKi	None	8.1	Binding	NoneNone	Drug Central	340	3	2	2	2.9	CCN(C(=O)N[C@@H]1CN(C)[C@H]2[C@H](C1)c1cccc3c1c(C2)c[nH]3)CC	None
		484	9633	51	None	-223	35	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
		951	9633	51	None	-223	35	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
		CHEMBL432	9633	51	None	-223	35	Human	4.3	pKi	None	4.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	169	2	4	4	0.1	NCC(c1ccc(c(c1)O)O)O	1826762
		2407	10145	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		59227	10145	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		941	10145	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		CHEMBL1303	10145	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		DB05271	10145	76	None	-128	7	Human	5.6	pKi	None	5.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	315	6	1	3	4.3	CCCN([C@H]1CCc2c(C1)cccc2O)CCc1cccs1	1826762
		228	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		228	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		33	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		33	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		6005	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		6005	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		CHEMBL53	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		CHEMBL53	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		DB00714	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	1826762
		DB00714	7233	28	None	-35	23	Human	5.8	pKi	None	5.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	267	0	2	3	2.9	CN1CCc2c3[C@H]1Cc1ccc(c(c1c3ccc2)O)O	7525564
		3153	7085	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
		3153	7085	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
		932	7085	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
		932	7085	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
		CHEMBL26736	7085	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	12388666
		CHEMBL26736	7085	28	None	-831	8	Human	5.9	pKi	None	5.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	179	0	3	3	0.9	NC1CCc2c(C1)cc(c(c2)O)O	1826762
		2105	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		2105	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		47811	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		47811	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		48	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		48	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		CHEMBL531	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		CHEMBL531	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		DB01186	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	12388666
		DB01186	9828	37	None	-123	32	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	314	4	1	2	4.3	CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3	1826762
		31101	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		31101	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		35	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		35	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		403	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		403	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		CHEMBL493	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		CHEMBL493	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		DB01200	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	12388666
		DB01200	7516	40	None	-436	35	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	653	5	3	6	3.2	CC(C[C@H]1C(=O)N2CCC[C@H]2[C@]2(N1C(=O)[C@@](O2)(NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c([nH]3)Br)C(C)C)O)C	1826762
		937	10387	0	None	-1	2	Human	6.2	pKi	None	6.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	1826762
		37	7565	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		460	7565	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		54746	7565	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		CHEMBL1201087	7565	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		DB00248	7565	60	None	-14	17	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	451	8	2	4	3.2	C=CCN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N(C(=O)NCC)CCCN(C)C	12388666
		1524	8962	96	None	-79	51	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		197	8962	96	None	-79	51	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		3822	8962	96	None	-79	51	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		88	8962	96	None	-79	51	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		CHEMBL51	8962	96	None	-79	51	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		DB12465	8962	96	None	-79	51	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	5	1	5	2.4	Fc1ccc(cc1)C(=O)C1CCN(CC1)CCn1c(=O)[nH]c2c(c1=O)cccc2	1826762
		2470	10425	50	None	-4168	58	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		3300	10425	50	None	-4168	58	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		5265	10425	50	None	-4168	58	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		99	10425	50	None	-4168	58	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		CHEMBL267930	10425	50	None	-4168	58	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	395	6	1	4	3.2	Fc1ccc(cc1)C(=O)CCCN1CCC2(CC1)C(=O)NCN2c1ccccc1	1826762
		135398737	7745	93	None	-44	90	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		38	7745	93	None	-44	90	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		722	7745	93	None	-44	90	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		CHEMBL42	7745	93	None	-44	90	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		DB00363	7745	93	None	-44	90	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	326	0	1	4	3.7	CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2c1cccc2	1826762
		100	10577	58	None	-47	54	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		2637	10577	58	None	-47	54	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		5452	10577	58	None	-47	54	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		CHEMBL479	10577	58	None	-47	54	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		DB00679	10577	58	None	-47	54	Human	7.0	pKi	None	7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	370	4	0	4	5.9	CSc1ccc2c(c1)N(CCC1CCCCN1C)c1c(S2)cccc1	1826762
		2726	7706	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		621	7706	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		83	7706	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		CHEMBL71	7706	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		DB00477	7706	68	None	-36	72	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	318	4	0	3	4.9	CN(CCCN1c2ccccc2Sc2c1cc(Cl)cc2)C	1826762
		1588	9105	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		28864	9105	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		43	9105	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		CHEMBL157138	9105	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		DB00589	9105	27	None	-131	44	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	338	3	2	2	2.8	CCN(C(=O)N[C@@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)c[nH]3)CC	12388666
		30137	9652	0	None	-676	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
		8594	9652	0	None	-676	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
		934	9652	0	None	-676	9	Human	7.4	pKi	None	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	2	2	3	3.6	CCCN1CCc2c3C1Cc1ccc(c(c1c3ccc2)O)O	1826762
		37459	7533	13	None	-10	24	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
		37459	7533	13	None	-10	24	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
		62	7533	13	None	-10	24	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
		62	7533	13	None	-10	24	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
		CHEMBL8514	7533	13	None	-10	24	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	1826762
		CHEMBL8514	7533	13	None	-10	24	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	361	0	1	2	4.8	O[C@]1(CCN2[C@@H](C1)c1cccc3c1[C@@H](C2)c1ccccc1CC3)C(C)(C)C	7525564
		1212	8443	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		204	8443	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		3372	8443	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		CHEMBL726	8443	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		DB00623	8443	50	None	-51	65	Human	7.7	pKi	None	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	437	6	1	5	4.3	OCCN1CCN(CC1)CCCN1c2ccccc2Sc2c1cc(cc2)C(F)(F)F	1826762
		173871	10386	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652
		936	10386	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652
		CHEMBL1193571	10386	2	None	4	3	Rat	8.7	pKi	None	8.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	269	1	2	3	2.7	CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)O)O	1973652

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Ligand source activities (1 row/activity)