Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
5ht2a_human 4.60x61 210 TM4 I => V 1.023↑ pK(b) (Functional - IP accumulation) pimavanserin Casey AB et al (2021)
5ht2a_human 4.63x64 213 TM4 F => K 2.089↑ pK(b) (Functional - IP accumulation) pimavanserin Casey AB et al (2021)
5ht2a_human 5.39x40 235 TM5 V => M 2.399↑ pK(b) (Functional - IP accumulation) pimavanserin Casey AB et al (2021)
5ht2a_human 5.42x43 238 TM5 G => S N/A pK(b) (Functional - IP accumulation) pimavanserin Casey AB et al (2021)
5ht2a_human 5.46x461 242 TM5 S => A 1.047↓ pK(b) (Functional - IP accumulation) pimavanserin Casey AB et al (2021)
5ht2a_human 4.60x61 210 TM4 I => V 1.175↓ pK(b) (Functional - IP accumulation) risperidone Casey AB et al (2021)
5ht2a_human 4.63x64 213 TM4 F => K 1.122↓ pK(b) (Functional - IP accumulation) risperidone Casey AB et al (2021)
5ht2a_human 5.39x40 235 TM5 V => M 1.122↑ pK(b) (Functional - IP accumulation) risperidone Casey AB et al (2021)
5ht2a_human 5.42x43 238 TM5 G => S 1.548↓ pK(b) (Functional - IP accumulation) risperidone Casey AB et al (2021)
5ht2a_human 5.46x461 242 TM5 S => A 1.175↑ pK(b) (Functional - IP accumulation) risperidone Casey AB et al (2021)
5ht2a_human 4.60x61 210 TM4 I => V 1.349↑ pK(b) (Functional - IP accumulation) CHEMBL3547134 Casey AB et al (2021)
5ht2a_human 4.63x64 213 TM4 F => K 1.412↓ pK(b) (Functional - IP accumulation) CHEMBL3547134 Casey AB et al (2021)
5ht2a_human 5.39x40 235 TM5 V => M 1.905↑ pK(b) (Functional - IP accumulation) CHEMBL3547134 Casey AB et al (2021)
5ht2a_human 5.42x43 238 TM5 G => S 12.658↓ pK(b) (Functional - IP accumulation) CHEMBL3547134 Casey AB et al (2021)
5ht2a_human 5.46x461 242 TM5 S => A 1.175↓ pK(b) (Functional - IP accumulation) CHEMBL3547134 Casey AB et al (2021)
5ht2a_human 4.60x61 210 TM4 I => V 1.413↑ pK(b) (Functional - IP accumulation) (2S,4R)-2k Casey AB et al (2021)
5ht2a_human 4.63x64 213 TM4 F => K 1.072↑ pK(b) (Functional - IP accumulation) (2S,4R)-2k Casey AB et al (2021)
5ht2a_human 5.39x40 235 TM5 V => M 2.754↑ pK(b) (Functional - IP accumulation) (2S,4R)-2k Casey AB et al (2021)
5ht2a_human 5.42x43 238 TM5 G => S 1000.0↓ pK(b) (Functional - IP accumulation) (2S,4R)-2k Casey AB et al (2021)
5ht2a_human 5.46x461 242 TM5 S => A 1.096↑ pK(b) (Functional - IP accumulation) (2S,4R)-2k Casey AB et al (2021)
5ht2a_human 4.60x61 210 TM4 I => V 1.622↑ pK(b) (Functional - IP accumulation) (2R,4R)-3h Casey AB et al (2021)
5ht2a_human 4.63x64 213 TM4 F => K 1.175↑ pK(b) (Functional - IP accumulation) (2R,4R)-3h Casey AB et al (2021)
5ht2a_human 5.39x40 235 TM5 V => M 1.122↑ pK(b) (Functional - IP accumulation) (2R,4R)-3h Casey AB et al (2021)
5ht2a_human 5.42x43 238 TM5 G => S 250.0↓ pK(b) (Functional - IP accumulation) (2R,4R)-3h Casey AB et al (2021)
5ht2a_human 5.46x461 242 TM5 S => A 1.318↓ pK(b) (Functional - IP accumulation) (2R,4R)-3h Casey AB et al (2021)
5ht2a_human 4.60x61 210 TM4 I => V 1.23↓ pEC50 (Functional - IP accumulation) 5-hydroxytryptamine Casey AB et al (2021)
5ht2a_human 4.63x64 213 TM4 F => K 2.088↓ pEC50 (Functional - IP accumulation) 5-hydroxytryptamine Casey AB et al (2021)
5ht2a_human 5.35x36 231 TM5 D => F Abolished pEC50 (Functional - IP accumulation) 5-hydroxytryptamine Casey AB et al (2021)
5ht2a_human 5.39x40 235 TM5 V => M 1.548↓ pEC50 (Functional - IP accumulation) 5-hydroxytryptamine Casey AB et al (2021)
5ht2a_human 5.42x43 238 TM5 G => S 14.493↓ pEC50 (Functional - IP accumulation) 5-hydroxytryptamine Casey AB et al (2021)
5ht2a_human 5.46x461 242 TM5 S => A 1.739↓ pEC50 (Functional - IP accumulation) 5-hydroxytryptamine Casey AB et al (2021)
5ht2a_human 6.51x51 339 TM6 F => L 17.857↓ EC50 (Functional - IP accumulation) 5-hydroxytryptamine Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 6.173↓ EC50 (Functional - IP accumulation) LSD Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 18.519↓ EC50 (Functional - IP accumulation) psilocin Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 100.0↓ EC50 (Functional - IP accumulation) 5-MeO-DMT Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 10.101↓ EC50 (Functional - IP accumulation) mescaline Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 10.101↓ EC50 (Functional - IP accumulation) CHEMBL287047 Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 250.0↓ EC50 (Functional - IP accumulation) 25H-NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 500.0↓ EC50 (Functional - IP accumulation) 25H-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 4.902↓ EC50 (Functional - IP accumulation) 24.0 Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 333.333↓ EC50 (Functional - IP accumulation) 24-NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 1000.0↓ EC50 (Functional - IP accumulation) 24-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 9.009↓ EC50 (Functional - IP accumulation) 25I Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 500.0↓ EC50 (Functional - IP accumulation) 25I-NB Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 62.5↓ EC50 (Functional - IP accumulation) NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 250.0↓ EC50 (Functional - IP accumulation) 25I-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 100.0↓ EC50 (Functional - IP accumulation) 25I-NBF Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 83.333↓ EC50 (Functional - IP accumulation) 25I-NBMD Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 1000.0↓ EC50 (Functional - IP accumulation) 5-hydroxytryptamine Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 71.429↓ EC50 (Functional - IP accumulation) LSD Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 500.0↓ EC50 (Functional - IP accumulation) psilocin Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 1000.0↓ EC50 (Functional - IP accumulation) 5-MeO-DMT Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 71.429↓ EC50 (Functional - IP accumulation) mescaline Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 142.857↓ EC50 (Functional - IP accumulation) CHEMBL287047 Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 90.909↓ EC50 (Functional - IP accumulation) 25H-NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 90.909↓ EC50 (Functional - IP accumulation) 25H-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 125.0↓ EC50 (Functional - IP accumulation) 24.0 Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 500.0↓ EC50 (Functional - IP accumulation) 24-NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 125.0↓ EC50 (Functional - IP accumulation) 24-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 38.462↓ EC50 (Functional - IP accumulation) 25I Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 142.857↓ EC50 (Functional - IP accumulation) 25I-NB Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 62.5↓ EC50 (Functional - IP accumulation) NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 76.923↓ EC50 (Functional - IP accumulation) 25I-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 250.0↓ EC50 (Functional - IP accumulation) 25I-NBF Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 142.857↓ EC50 (Functional - IP accumulation) 25I-NBMD Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A N/A N/A Kao HT et al (1992)
5ht2a_human 2.50x50 120 TM2 D => A N/A N/A Sealfon SC et al (1995)
5ht2a_human 2.50x50 120 TM2 D => N N/A N/A Sealfon SC et al (1995)
5ht2a_human 7.49x49 376 TM7 N => A N/A N/A Sealfon SC et al (1995)
5ht2a_human 7.49x49 376 TM7 N => D N/A N/A Sealfon SC et al (1995)
5ht2a_human 5.46x461 242 TM5 S => A N/A N/A Almaula N et al (1996)
5ht2a_human 3.36x36 159 TM3 S => A N/A N/A Almaula N et al (1996)
5ht2a_human 3.36x36 159 TM3 S => C N/A N/A Almaula N et al (1996)
5ht2a_human 25 N-term T => N N/A N/A Harvey L et al (2003)
5ht2a_human 4.47x47 197 TM4 I => V N/A N/A Harvey L et al (2003)
5ht2a_human 5.46x461 242 TM5 S => A N/A N/A Roth BL et al (1998)
5ht2a_human 447 C-term A => V N/A N/A Harvey L et al (2003)
5ht2a_human 452 C-term H => Y N/A N/A Harvey L et al (2003)
5ht2a_human 6.51x51 339 TM6 F => L N/A N/A Braden MR et al (2006)
5ht2a_human 6.52x52 340 TM6 F => L N/A N/A Braden MR et al (2006)
5ht2a_human 1.50x50 92 TM1 N => G N/A N/A Brockhoff A et al (2010)
5ht2a_human 1.29x29 71 TM1 L => F N/A N/A Brockhoff A et al (2010)
5ht2a_human 6.51x51 339 TM6 F => L 12.346↓ K(i) (Binding - Radioligand competition/displacement) 25I-NB Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 100.0↓ K(i) (Binding - Radioligand competition/displacement) 25I-NB Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 21.739↓ K(i) (Binding - Radioligand competition/displacement) ergometrine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 66.923↑ K(d) (Binding - Radioligand saturation) mesulergine Kao HT et al (1992) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 30.714↑ K(i) (Binding - Radioligand competition/displacement) mesulergine Kao HT et al (1992) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 7.179↑ K(i) (Binding - Radioligand competition/displacement) mesulergine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 6.061↓ K(i) (Binding - Radioligand competition/displacement) lisuride Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 2.494↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL18845 Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 47.619↓ K(i) (Binding - Radioligand competition/displacement) NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 28.571↓ K(i) (Binding - Radioligand competition/displacement) NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 2.994↓ K(i) (Binding - Radioligand competition/displacement) mescaline Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 4.255↓ K(i) (Binding - Radioligand competition/displacement) mescaline Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.34x34 322 TM6 C => K 1.059↓ K(i) (Binding - Radioligand competition/displacement) ritanserin Muntasir HA et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 15.385↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL287047 Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 8.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL287047 Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 3.597↓ K(i) (Binding - Radioligand competition/displacement) 25I Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 6.41↓ K(i) (Binding - Radioligand competition/displacement) 25I Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => N 1.192↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => N 1.88↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 3.36x36 159 TM3 S => A 17.544↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 3.36x36 159 TM3 S => C 4.926↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 3.636↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 6.34x34 322 TM6 C => K 9.6↑ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Muntasir HA et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 12.346↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L N/A K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 3.36x36 159 TM3 S => A 3.984↓ K(i) (Binding - Radioligand competition/displacement) bufotenine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 3.36x36 159 TM3 S => C 1.383↓ K(i) (Binding - Radioligand competition/displacement) bufotenine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 2.597↓ K(i) (Binding - Radioligand competition/displacement) bufotenine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => N 1.471↑ K(i) (Binding - Radioligand competition/displacement) LSD Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 3.36x36 159 TM3 S => A 1.42↓ K(i) (Binding - Radioligand competition/displacement) LSD Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 3.36x36 159 TM3 S => C 1.152↑ K(i) (Binding - Radioligand competition/displacement) LSD Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 8.772↓ K(i) (Binding - Radioligand competition/displacement) LSD Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 1.499↓ K(i) (Binding - Radioligand competition/displacement) LSD Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 16.129↓ K(i) (Binding - Radioligand competition/displacement) LSD Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => N 1.437↓ K(d) (Binding - Radioligand saturation) ketanserin Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 1.531↑ K(d) (Binding - Radioligand saturation) ketanserin Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 6.34x34 322 TM6 C => K 1.222↑ K(i) (Binding - Radioligand competition/displacement) ketanserin Muntasir HA et al (2006) Vass M et al (2019)
5ht2a_human 6.34x34 322 TM6 C => K 5.78↓ K(i) (Binding - Radioligand competition/displacement) cyproheptadine Muntasir HA et al (2006) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => A 1.164↑ K(d) (Binding - Radioligand saturation) NORDIHYDROGUAIARETIC ACID Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 6.34x34 322 TM6 C => K 1.912↓ K(i) (Binding - Radioligand competition/displacement) sarpogrelate Muntasir HA et al (2006) Vass M et al (2019)
5ht2a_human 7.49x49 376 TM7 N => D 1.203↓ K(d) (Binding - Radioligand saturation) apomorphine Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 10.101↓ K(d) (Binding - Radioligand saturation) haloperidol Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 2.75↑ K(d) (Binding - Radioligand saturation) haloperidol Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => N 1.121↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 3.36x36 159 TM3 S => A 1.309↓ K(d) (Binding - Radioligand saturation) haloperidol Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 3.36x36 159 TM3 S => C 1.273↑ K(d) (Binding - Radioligand saturation) haloperidol Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 7.49x49 376 TM7 N => A 1.515↓ K(d) (Binding - Radioligand saturation) haloperidol Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => N 1.271↓ K(i) (Binding - Radioligand competition/displacement) mianserin Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 3.195↓ K(i) (Binding - Radioligand competition/displacement) psilocin Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 2.421↓ K(i) (Binding - Radioligand competition/displacement) psilocin Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 166.667↓ K(i) (Binding - Radioligand competition/displacement) psilocin Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 1.103↓ K(d) (Binding - Radioligand saturation) DOI Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => N 1.6↓ K(i) (Binding - Radioligand competition/displacement) DOI Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 3.401↓ K(i) (Binding - Radioligand competition/displacement) DOI Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 3.759↓ K(i) (Binding - Radioligand competition/displacement) tryptamine Almaula N et al (1996) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 17.241↓ K(i) (Binding - Radioligand competition/displacement) 5-MeO-DMT Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 500.0↓ K(i) (Binding - Radioligand competition/displacement) 5-MeO-DMT Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 2.50x50 120 TM2 D => N 1.44↑ K(i) (Binding - Radioligand competition/displacement) 5-Metoxygramine Sealfon SC et al (1995) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 4.566↓ K(i) (Binding - Radioligand competition/displacement) 25H-NMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 7.407↓ K(i) (Binding - Radioligand competition/displacement) 25H-NMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 3.401↓ K(i) (Binding - Radioligand competition/displacement) 24.0 Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 8.403↓ K(i) (Binding - Radioligand competition/displacement) 24.0 Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 30.303↓ K(i) (Binding - Radioligand competition/displacement) 25I-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 23.256↓ K(i) (Binding - Radioligand competition/displacement) 25I-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 40.0↓ K(i) (Binding - Radioligand competition/displacement) 25H-NB Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 37.037↓ K(i) (Binding - Radioligand competition/displacement) 25H-NB Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 6.061↓ K(i) (Binding - Radioligand competition/displacement) 25H-NPr Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 2.732↓ K(i) (Binding - Radioligand competition/displacement) 25H-NPr Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.34x34 322 TM6 C => K 1.02↓ K(i) (Binding - Radioligand competition/displacement) M-1 Muntasir HA et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 58.824↓ K(i) (Binding - Radioligand competition/displacement) 25I-NBF Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 200.0↓ K(i) (Binding - Radioligand competition/displacement) 25I-NBF Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 5.917↓ K(i) (Binding - Radioligand competition/displacement) 25I-NBMD Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 4.484↓ K(i) (Binding - Radioligand competition/displacement) 25I-NBMD Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 200.0↓ K(i) (Binding - Radioligand competition/displacement) 24-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 100.0↓ K(i) (Binding - Radioligand competition/displacement) 24-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 66.667↓ K(i) (Binding - Radioligand competition/displacement) 24-NB Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 45.455↓ K(i) (Binding - Radioligand competition/displacement) 24-NB Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 1000.0↓ K(i) (Binding - Radioligand competition/displacement) 25H-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 23.81↓ K(i) (Binding - Radioligand competition/displacement) 25H-NBOH Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 32.258↓ K(i) (Binding - Radioligand competition/displacement) 25I-Nnap Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 40.0↓ K(i) (Binding - Radioligand competition/displacement) 25I-Nnap Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 142.857↓ K(i) (Binding - Radioligand competition/displacement) 24-NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 142.857↓ K(i) (Binding - Radioligand competition/displacement) 24-NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.51x51 339 TM6 F => L 500.0↓ K(i) (Binding - Radioligand competition/displacement) 25H-NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 6.52x52 340 TM6 F => L 62.5↓ K(i) (Binding - Radioligand competition/displacement) 25H-NBOMe Braden MR et al (2006) Vass M et al (2019)
5ht2a_human 45.52x52 229 ECL2 L => A 2.457↓ K(d) (Binding - Radioligand saturation) LSD Wacker D et al (2017)
5ht2a_human 3.33x33 156 TM3 V => A >90.909↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 3.40x40 163 TM3 I => A >90.909↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 4.56x56 206 TM4 I => V 1.333↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 4.60x61 210 TM4 I => V 1.297↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 45.51x51 228 ECL2 L => A 1.927↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 45.52x52 229 ECL2 L => A >90.909↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 5.42x43 238 TM5 G => S 1.89↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 1.198↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 6.44x44 332 TM6 F => L 2.062↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => F 1.351↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 6.51x51 339 TM6 F => A >90.909↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 6.52x52 340 TM6 F => A >90.909↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => N 1.404↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 7.43x42 370 TM7 Y => A >90.909↓ K(d) (Binding - Radioligand competition/displacement) mesulergine Kimura KT et al (2019)
5ht2a_human 4.56x56 206 TM4 I => V 2.464↑ K(i) (Binding - Radioligand competition/displacement) risperidone Kimura KT et al (2019)
5ht2a_human 4.60x61 210 TM4 I => V 1.643↑ K(i) (Binding - Radioligand competition/displacement) risperidone Kimura KT et al (2019)
5ht2a_human 45.51x51 228 ECL2 L => A 1.29↓ K(i) (Binding - Radioligand competition/displacement) risperidone Kimura KT et al (2019)
5ht2a_human 5.42x43 238 TM5 G => S 1.333↓ K(i) (Binding - Radioligand competition/displacement) risperidone Kimura KT et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 1.353↑ K(i) (Binding - Radioligand competition/displacement) risperidone Kimura KT et al (2019)
5ht2a_human 6.44x44 332 TM6 F => L 1.536↓ K(i) (Binding - Radioligand competition/displacement) risperidone Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => F >142.857↓ K(i) (Binding - Radioligand competition/displacement) risperidone Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => N >142.857↓ K(i) (Binding - Radioligand competition/displacement) risperidone Kimura KT et al (2019)
5ht2a_human 6.44x44 332 TM6 F => L 1.905↑ K(i) (Binding - Radioligand competition/displacement) zotepine Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => F >25.0↓ K(i) (Binding - Radioligand competition/displacement) zotepine Kimura KT et al (2019)
5ht2a_human 4.56x56 206 TM4 I => V 3.958↑ K(i) (Binding - Radioligand competition/displacement) pimavanserin Kimura KT et al (2019)
5ht2a_human 4.60x61 210 TM4 I => V 1.631↓ K(i) (Binding - Radioligand competition/displacement) pimavanserin Kimura KT et al (2019)
5ht2a_human 5.42x43 238 TM5 G => S 19.231↓ K(i) (Binding - Radioligand competition/displacement) pimavanserin Kimura KT et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 1.789↓ K(i) (Binding - Radioligand competition/displacement) pimavanserin Kimura KT et al (2019)
5ht2a_human 2.61x60 131 TM2 S => A 7.368↑ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 3.28x28 151 TM3 W => A 3.003↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 3.33x33 156 TM3 V => A 6.135↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 3.36x36 159 TM3 S => A 2.717↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 3.37x37 160 TM3 T => A 2.571↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 3.40x40 163 TM3 I => A Abolished K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 4.56x56 206 TM4 I => V 1.499↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 4.60x61 210 TM4 I => V 1.0 K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 45.51x51 228 ECL2 L => A 4.717↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 45.52x52 229 ECL2 L => A 2.141↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 5.39x40 235 TM5 V => A 2.857↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 5.42x43 238 TM5 G => S 1.642↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 1.474↑ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 5.47x47 243 TM5 F => L 45.455↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 6.44x44 332 TM6 F => L 17.241↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => L N/A K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => F Abolished K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 6.51x51 339 TM6 F => A Abolished K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 6.52x52 340 TM6 F => A 2.212↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 6.55x55 343 TM6 N => A 2.295↑ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 7.35x34 362 TM7 L => A 3.067↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 7.36x35 363 TM7 N => A 3.415↑ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => A 1.167↑ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => N 34.483↓ K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(b) (Functional - Other) risperidone Kimura KT et al (2019)
5ht2a_human 2.61x60 131 TM2 S => A 1.391↑ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 3.28x28 151 TM3 W => A 6.897↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 3.33x33 156 TM3 V => A 15.625↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 3.36x36 159 TM3 S => A 18.182↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 3.37x37 160 TM3 T => A 2.033↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 3.40x40 163 TM3 I => A Abolished K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 4.56x56 206 TM4 I => V 1.218↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 4.60x61 210 TM4 I => V 1.28↑ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 45.51x51 228 ECL2 L => A 1.376↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 45.52x52 229 ECL2 L => A 4.367↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 5.39x40 235 TM5 V => A 3.03↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 5.42x43 238 TM5 G => S 2.66↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 1.406↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 5.47x47 243 TM5 F => L 19.231↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 6.44x44 332 TM6 F => L 11.628↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => L N/A K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => F Abolished K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 6.51x51 339 TM6 F => A Abolished K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 6.52x52 340 TM6 F => A 47.619↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 6.55x55 343 TM6 N => A 1.032↑ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 7.35x34 362 TM7 L => A 1.185↑ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 7.36x35 363 TM7 N => A 1.783↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => A 1.231↑ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => N 1.531↓ K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(b) (Functional - Other) zotepine Kimura KT et al (2019)
5ht2a_human 2.61x60 131 TM2 S => A 1.967↑ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 3.28x28 151 TM3 W => A 5.076↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 3.33x33 156 TM3 V => A 13.333↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 3.36x36 159 TM3 S => A 5.0↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 3.37x37 160 TM3 T => A 5.076↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 3.40x40 163 TM3 I => A Abolished K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 4.56x56 206 TM4 I => V 2.252↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 4.60x61 210 TM4 I => V 1.499↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 45.51x51 228 ECL2 L => A 1.25↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 45.52x52 229 ECL2 L => A 14.085↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 5.39x40 235 TM5 V => A 3.086↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 5.42x43 238 TM5 G => S N/A K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 1.667↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 5.47x47 243 TM5 F => L 25.0↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 6.44x44 332 TM6 F => L 10.0↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => L 1000.0↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => F Abolished K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 6.51x51 339 TM6 F => A Abolished K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 6.52x52 340 TM6 F => A 19.231↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 6.55x55 343 TM6 N => A 2.252↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 7.35x34 362 TM7 L => A 1.0 K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 7.36x35 363 TM7 N => A 1.416↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => A 5.714↑ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => N 3.413↓ K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(b) (Functional - Other) pimavanserin Kimura KT et al (2019)
5ht2a_human 2.61x60 131 TM2 S => A 1.463↑ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 3.28x28 151 TM3 W => A 31.25↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 3.32x32 155 TM3 D => A Abolished EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 3.33x33 156 TM3 V => A 111.111↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 3.36x36 159 TM3 S => A 250.0↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 3.37x37 160 TM3 T => A 10.87↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 3.40x40 163 TM3 I => A Abolished EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 4.56x56 206 TM4 I => V 1.916↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 4.60x61 210 TM4 I => V 1.416↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 45.51x51 228 ECL2 L => A 1.333↑ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 45.52x52 229 ECL2 L => A 16.667↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 5.39x40 235 TM5 V => A 3.663↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 5.42x43 238 TM5 G => S 19.231↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 5.46x461 242 TM5 S => A 2.0↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 5.47x47 243 TM5 F => L 27.027↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 6.44x44 332 TM6 F => L 14.085↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => L 14.085↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 6.48x48 336 TM6 W => F Abolished EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 6.51x51 339 TM6 F => A 500.0↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 6.52x52 340 TM6 F => A 30.303↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 6.55x55 343 TM6 N => A 45.455↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 7.35x34 362 TM7 L => A 2.747↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 7.36x35 363 TM7 N => A 1.916↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => A 2.165↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 7.39x38 366 TM7 V => N 2.915↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 7.43x42 370 TM7 Y => A 500.0↓ EC50 (Functional - Other) fluoxetine Kimura KT et al (2019)
5ht2a_human 3.32x32 155 TM3 D => A Abolished EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 3.36x36 159 TM3 S => A 166.667↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 45.52x52 229 ECL2 L => A 37.037↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 5.42x43 238 TM5 G => A 1.603↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 5.43x44 239 TM5 S => A 27.027↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 5.46x461 242 TM5 S => A 1.664↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 6.48x48 336 TM6 W => A Abolished EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 6.51x51 339 TM6 F => L 17.857↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 7.42x41 369 TM7 G => A 3.012↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 7.45x45 372 TM7 S => A 1.724↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => A 111.111↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => E 250.0↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 6.55x55 343 TM6 N => A 34.483↓ EC50 (Functional - Other) fluoxetine Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => A 2.86↑ EC50 (Functional - β-arrestin recruitment) fluoxetine Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => E 3.084↑ EC50 (Functional - β-arrestin recruitment) fluoxetine Kim K et al (2020)
5ht2a_human 3.32x32 155 TM3 D => A Abolished EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 3.36x36 159 TM3 S => A 166.667↓ EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 45.52x52 229 ECL2 L => A 7.874↓ EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 5.42x43 238 TM5 G => A 1.18↑ EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 5.43x44 239 TM5 S => A 16.667↓ EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 5.46x461 242 TM5 S => A 2.545↓ EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 6.48x48 336 TM6 W => A Abolished EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 6.51x51 339 TM6 F => L 250.0↓ EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 7.42x41 369 TM7 G => A Abolished EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 7.45x45 372 TM7 S => A 1.255↓ EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => A Abolished EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => E Abolished EC50 (Functional - Other) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 6.55x55 343 TM6 N => A 2.427↓ EC50 (Functional - Other) tryptamine Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => A 1.283↑ EC50 (Functional - β-arrestin recruitment) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => E 1.485↑ EC50 (Functional - β-arrestin recruitment) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 3.32x32 155 TM3 D => A 100.0↓ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 3.36x36 159 TM3 S => A 4.484↓ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 45.52x52 229 ECL2 L => A 47.619↓ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 5.42x43 238 TM5 G => A 1.412↑ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 5.43x44 239 TM5 S => A 3.155↓ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 5.46x461 242 TM5 S => A 3.906↓ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 6.48x48 336 TM6 W => A Abolished EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 6.51x51 339 TM6 F => L 8.197↓ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 7.42x41 369 TM7 G => A 11.111↓ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 7.45x45 372 TM7 S => A 1.145↓ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => A Abolished EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => E Abolished EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 6.55x55 343 TM6 N => A 2.054↑ EC50 (Functional - Other) LSD Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => A 3.651↑ EC50 (Functional - β-arrestin recruitment) LSD Kim K et al (2020)
5ht2a_human 34.51x51 181 ICL2 I => E 1.83↑ EC50 (Functional - β-arrestin recruitment) LSD Kim K et al (2020)
5ht2a_human 3.32x32 155 TM3 D => A Abolished pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 3.36x36 159 TM3 S => A 100.0↓ pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 45.52x52 229 ECL2 L => A 2.817↓ pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 5.42x43 238 TM5 G => A 1.148↓ pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 5.43x44 239 TM5 S => A 19.608↓ pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 5.46x461 242 TM5 S => A 1.047↓ pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 6.48x48 336 TM6 W => A Abolished pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 6.51x51 339 TM6 F => L Abolished pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 7.42x41 369 TM7 G => A 1.778↑ pK(i) (Binding - Radioligand competition/displacement) fluoxetine Kim K et al (2020)
5ht2a_human 3.32x32 155 TM3 D => A Abolished pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 3.36x36 159 TM3 S => A 142.857↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 45.52x52 229 ECL2 L => A 3.472↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 5.42x43 238 TM5 G => A 4.902↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 5.43x44 239 TM5 S => A 10.526↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 5.46x461 242 TM5 S => A 2.755↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 6.48x48 336 TM6 W => A Abolished pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 6.51x51 339 TM6 F => L Abolished pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 7.42x41 369 TM7 G => A 1.548↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL5184791 Kim K et al (2020)
5ht2a_human 3.32x32 155 TM3 D => A Abolished pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 3.36x36 159 TM3 S => A 1.622↑ pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 45.52x52 229 ECL2 L => A 3.09↑ pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 5.42x43 238 TM5 G => A 2.398↓ pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 5.43x44 239 TM5 S => A 3.39↓ pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 5.46x461 242 TM5 S => A 2.882↓ pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 6.48x48 336 TM6 W => A Abolished pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 6.51x51 339 TM6 F => L Abolished pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 7.42x41 369 TM7 G => A 1.175↓ pK(i) (Binding - Radioligand competition/displacement) LSD Kim K et al (2020)
5ht2a_human 3.32x32 155 TM3 D => A Abolished pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 3.36x36 159 TM3 S => A 1.047↓ pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 45.52x52 229 ECL2 L => A 2.239↑ pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 5.42x43 238 TM5 G => A 1.905↓ pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 5.43x44 239 TM5 S => A 2.882↓ pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 5.46x461 242 TM5 S => A 1.621↓ pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 6.48x48 336 TM6 W => A Abolished pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 6.51x51 339 TM6 F => L Abolished pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 7.42x41 369 TM7 G => A 15.873↓ pK(i) (Binding - Radioligand competition/displacement) methiothepin Kim K et al (2020)
5ht2a_human 3.25x25 148 TM3 C => A 11.111↓ (Binding - Radioligand saturation) LSD Cimadevila M et al (2020)
5ht2a_human 45.50x50 227 ECL2 C => A 14.493↓ (Binding - Radioligand saturation) LSD Cimadevila M et al (2020)
5ht2a_human 3.25x25 148 TM3 C => A Abolished (Functional - IP accumulation) fluoxetine Cimadevila M et al (2020)
5ht2a_human 45.50x50 227 ECL2 C => A Abolished (Functional - IP accumulation) fluoxetine Cimadevila M et al (2020)
5ht2a_human 3.25x25 148 TM3 C => A Abolished (Functional - IP accumulation) LSD Cimadevila M et al (2020)
5ht2a_human 45.50x50 227 ECL2 C => A Abolished (Functional - IP accumulation) LSD Cimadevila M et al (2020)
5ht2a_human 3.25x25 148 TM3 C => A Abolished (Functional - IP accumulation) DOI Cimadevila M et al (2020)
5ht2a_human 45.50x50 227 ECL2 C => A Abolished (Functional - IP accumulation) DOI Cimadevila M et al (2020)
5ht2a_human 3.25x25 148 TM3 C => A Abolished (Functional - Ca2+ accumulation) fluoxetine Cimadevila M et al (2020)
5ht2a_human 45.50x50 227 ECL2 C => A Abolished (Functional - Ca2+ accumulation) fluoxetine Cimadevila M et al (2020)
5ht2a_human 3.25x25 148 TM3 C => A Abolished (Functional - Ca2+ accumulation) LSD Cimadevila M et al (2020)
5ht2a_human 45.50x50 227 ECL2 C => A Abolished (Functional - Ca2+ accumulation) LSD Cimadevila M et al (2020)
5ht2a_human 3.25x25 148 TM3 C => A Abolished (Functional - Ca2+ accumulation) DOI Cimadevila M et al (2020)
5ht2a_human 45.50x50 227 ECL2 C => A Abolished (Functional - Ca2+ accumulation) DOI Cimadevila M et al (2020)
5ht2a_human 291 ICL3 S => A Unchanged (Functional - Ca2+ accumulation) fluoxetine Soman S et al (2020)
5ht2a_human 429 C-term K => A Unchanged (Functional - Ca2+ accumulation) fluoxetine Soman S et al (2020)
5ht2a_human 307 ICL3 T => A Unchanged (Functional - Ca2+ accumulation) fluoxetine Soman S et al (2020)
5ht2a_human 291 ICL3 S => A Unchanged (Functional - Ca2+ accumulation) DOI Soman S et al (2020)
5ht2a_human 429 C-term K => A Unchanged (Functional - Ca2+ accumulation) DOI Soman S et al (2020)
5ht2a_human 307 ICL3 T => A Unchanged (Functional - Ca2+ accumulation) DOI Soman S et al (2020)
5ht2a_human 291 ICL3 S => A Unchanged (Functional - Ca2+ accumulation) dopamine Soman S et al (2020)
5ht2a_human 429 C-term K => A Decreased (Functional - Ca2+ accumulation) dopamine Soman S et al (2020)
5ht2a_human 307 ICL3 T => A Unchanged (Functional - Ca2+ accumulation) dopamine Soman S et al (2020)
5ht2a_human 291 ICL3 S => A Unchanged (Functional - Ca2+ accumulation) 2-methyl-5-HT Soman S et al (2020)
5ht2a_human 429 C-term K => A Unchanged (Functional - Ca2+ accumulation) 2-Me-5-HT Soman S et al (2020)
5ht2a_human 307 ICL3 T => A Unchanged (Functional - Ca2+ accumulation) Methcathinone, (-) Soman S et al (2020)
5ht2a_human 291 ICL3 S => A Unchanged (Functional - Other) fluoxetine Soman S et al (2020)
5ht2a_human 429 C-term K => A Unchanged (Functional - Other) fluoxetine Soman S et al (2020)
5ht2a_human 307 ICL3 T => A Unchanged (Functional - Other) fluoxetine Soman S et al (2020)
5ht2a_human 291 ICL3 S => A Unchanged (Functional - Other) DOI Soman S et al (2020)
5ht2a_human 429 C-term K => A Unchanged (Functional - Other) DOI Soman S et al (2020)
5ht2a_human 307 ICL3 T => A Unchanged (Functional - Other) DOI Soman S et al (2020)
5ht2a_human 291 ICL3 S => A Unchanged (Functional - Other) dopamine Soman S et al (2020)
5ht2a_human 429 C-term K => A Decreased (Functional - Other) dopamine Soman S et al (2020)
5ht2a_human 307 ICL3 T => A Decreased (Functional - Other) dopamine Soman S et al (2020)
5ht2a_human 291 ICL3 S => A Unchanged (Functional - Other) 2-methyl-5-HT Soman S et al (2020)
5ht2a_human 429 C-term K => A Unchanged (Functional - Other) 2-Me-5-HT Soman S et al (2020)
5ht2a_human 307 ICL3 T => A Unchanged (Functional - Other) Methcathinone, (-) Soman S et al (2020)
5ht2a_human 3.28x28 151 TM3 W => A Abolished K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 3.36x36 159 TM3 S => A 3.003↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 5.46x461 242 TM5 S => A 2.865↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 5.47x47 243 TM5 F => A 3.861↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 6.51x51 339 TM6 F => A 20.833↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 6.52x52 340 TM6 F => A 7.194↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 7.35x34 362 TM7 L => A 2.433↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 7.36x35 363 TM7 N => A 5.988↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 7.39x38 366 TM7 V => A 4.854↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 3.33x33 156 TM3 V => A Abolished K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 3.37x37 160 TM3 T => A 3.448↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 3.40x40 163 TM3 I => A 40.0↓ K(i) (Binding - Radioligand competition/displacement) LUMATEPERONE Cao D et al (2022)
5ht2a_human 3.28x28 151 TM3 W => A Abolished K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 3.36x36 159 TM3 S => A 5.051↓ K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 5.46x461 242 TM5 S => A 1.202↑ K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 5.47x47 243 TM5 F => A 13.889↓ K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 6.51x51 339 TM6 F => A 43.478↓ K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 6.52x52 340 TM6 F => A 12.987↓ K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 7.35x34 362 TM7 L => A 1.383↓ K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 7.36x35 363 TM7 N => A 13.889↓ K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 7.39x38 366 TM7 V => A 1.024↓ K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(i) (Binding - Radioligand competition/displacement) IHCH-7086 Cao D et al (2022)
5ht2a_human 3.28x28 151 TM3 W => A Abolished K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 7.35x34 362 TM7 L => A 11.494↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 3.33x33 156 TM3 V => A Abolished K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 45.51x51 228 ECL2 L => A 4.566↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 45.52x52 229 ECL2 L => A 8.13↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 6.51x51 339 TM6 F => A 13.158↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 3.36x36 159 TM3 S => A Abolished K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 3.37x37 160 TM3 T => A 5.882↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 5.43x44 239 TM5 S => A 31.25↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 5.46x461 242 TM5 S => A 13.514↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 6.48x48 336 TM6 W => A Abolished K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 6.52x52 340 TM6 F => A 17.241↓ K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(i) (Binding - Radioligand competition/displacement) 5-hydroxytryptamine Cao D et al (2022)
5ht2a_human 3.28x28 151 TM3 W => A Abolished K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 7.35x34 362 TM7 L => A 2.457↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 3.33x33 156 TM3 V => A Abolished K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 45.51x51 228 ECL2 L => A 1.739↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 45.52x52 229 ECL2 L => A 2.342↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 6.51x51 339 TM6 F => A 12.821↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 3.36x36 159 TM3 S => A 4.673↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 3.37x37 160 TM3 T => A 2.137↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 5.43x44 239 TM5 S => A 3.546↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 5.46x461 242 TM5 S => A 4.785↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 6.48x48 336 TM6 W => A Abolished K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 6.52x52 340 TM6 F => A 7.407↓ K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(i) (Binding - Radioligand competition/displacement) psilocin Cao D et al (2022)
5ht2a_human 3.28x28 151 TM3 W => A Abolished K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 7.35x34 362 TM7 L => A 1.02↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 3.33x33 156 TM3 V => A Abolished K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 45.51x51 228 ECL2 L => A 2.288↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 45.52x52 229 ECL2 L => A 2.941↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 6.51x51 339 TM6 F => A 1.633↑ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 3.36x36 159 TM3 S => A 1.38↑ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 3.37x37 160 TM3 T => A 1.143↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 5.43x44 239 TM5 S => A 1.511↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 5.46x461 242 TM5 S => A 3.012↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 6.48x48 336 TM6 W => A Abolished K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 6.52x52 340 TM6 F => A 1.092↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 5.47x47 243 TM5 F => A 1.988↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 7.36x35 363 TM7 N => A 1.441↑ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 7.39x38 366 TM7 V => A 1.153↑ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 3.40x40 163 TM3 I => A 23.256↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => W 1.988↓ K(d) (Binding - Radioligand saturation) Lysergide Cao D et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => W 3.774↓ K(d) (Binding - Radioligand competition/displacement) Lysergide Cao D et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => W 1.786↓ K(d) (Binding - Radioligand competition/displacement) lisuride Cao D et al (2022)
5ht2a_human 3.28x28 151 TM3 W => A 2.66↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 45.51x51 228 ECL2 L => A 17.544↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 45.52x52 229 ECL2 L => A 3.268↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 5.47x47 243 TM5 F => A Abolished K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 5.48x48 244 TM5 F => A 3.509↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 5.51x51 247 TM5 L => A 2.481↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 6.44x44 332 TM6 F => A 3.056↑ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 6.45x45 333 TM6 V => A 1.603↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 6.48x48 336 TM6 W => A Abolished K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 6.49x49 337 TM6 C => A 1.842↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 6.51x51 339 TM6 F => A Abolished K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 6.52x52 340 TM6 F => A 4.95↓ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 7.39x38 366 TM7 V => A 2.661↑ K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(i) (Binding - Radioligand competition/displacement) aripiprazole Chen Z et al (2022)
5ht2a_human 3.28x28 151 TM3 W => A 2.146↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 3.32x32 155 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 45.51x51 228 ECL2 L => A 11.236↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 45.52x52 229 ECL2 L => A 2.899↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 5.47x47 243 TM5 F => A Abolished K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 5.48x48 244 TM5 F => A 6.944↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 5.51x51 247 TM5 L => A 3.401↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 6.44x44 332 TM6 F => A 1.897↑ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 6.45x45 333 TM6 V => A 6.494↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 6.48x48 336 TM6 W => A Abolished K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 6.49x49 337 TM6 C => A 3.817↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 6.51x51 339 TM6 F => A N/A K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 6.52x52 340 TM6 F => A 4.098↓ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 7.39x38 366 TM7 V => A 5.106↑ K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
5ht2a_human 7.43x42 370 TM7 Y => A Abolished K(i) (Binding - Radioligand competition/displacement) cariprazine Chen Z et al (2022)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM1
1x29 1.29x29 L71
1x50 1.50x50 N92
TM2
2x50 2.50x50 D120
2x60 2.61x60 S131
TM3
3x25 3.25x25 C148
3x28 3.28x28 W151
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
3x40 3.40x40 I163
TM4
4x47 4.47x47 I197
4x56 4.56x56 I206
4x61 4.60x61 I210
4x64 4.63x64 F213
TM5
5x36 5.35x36 D231
5x40 5.39x40 V235
5x43 5.42x43 G238
5x44 5.43x44 S239
5x461 5.46x461 S242
5x47 5.47x47 F243
5x48 5.48x48 F244
5x51 5.51x51 L247
TM6
6x34 6.34x34 C322
6x44 6.44x44 F332
6x45 6.45x45 V333
6x48 6.48x48 W336
6x49 6.49x49 C337
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343
TM7
7x34 7.35x34 L362
7x35 7.36x35 N363
7x38 7.39x38 V366
7x41 7.42x41 G369
7x42 7.43x42 Y370
7x45 7.45x45 S372
7x49 7.49x49 N376