Biased Signaling Atlas

Mutant Browser

Protein name	Generic number	Position	Segment	Mutation	FoldChange or Qual	Exp Type	Ligand	Reference	Review

aa1r_human	3.39x39	94	TM3	S => T	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	1.39x39	16	TM1	E => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	1.39x39	16	TM1	E => Q	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	2.45x45	50	TM2	S => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	2.50x50	55	TM2	D => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	3.38x38	93	TM3	S => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	3.39x39	94	TM3	S => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	4.53x53	135	TM4	S => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	4.59x59	141	TM4	T => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	7.42x41	277	TM7	T => S	N/A	N/A		Townsend-Nicholson A et al (1994)
aa1r_human	7.42x41	277	TM7	T => A	N/A	N/A		Townsend-Nicholson A et al (1994)
aa1r_human	7.42x41	277	TM7	T => A	N/A	N/A		Dalpiaz A et al (1998)
aa1r_human	2.65x64	70	TM2	N => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.37x37	92	TM3	Q => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.32x32	87	TM3	V => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.33x33	88	TM3	L => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.36x36	91	TM3	T => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	2.41x41	46	TM2	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	2.41x41	46	TM2	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.25x25	80	TM3	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.25x25	80	TM3	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.30x30	85	TM3	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.30x30	85	TM3	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	4.49x49	131	TM4	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	4.49x49	131	TM4	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	45.50x50	169	ECL2	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	45.50x50	169	ECL2	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	6.56x56	255	TM6	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	6.56x56	255	TM6	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	6.61x61	260	TM6	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	6.61x61	260	TM6	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human		263	ECL3	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human		263	ECL3	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	8.64x64	309	H8	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	8.64x64	309	H8	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	8.64x64	309	H8	C => A	N/A	N/A		Gao Z et al (1999)
aa1r_human	1.37x37	14	TM1	G => T	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	1.39x39	16	TM1	E => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	1.48x48	25	TM1	P => L	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	2.41x41	46	TM2	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	2.41x41	46	TM2	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	2.50x50	55	TM2	D => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	3.25x25	80	TM3	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.25x25	80	TM3	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.30x30	85	TM3	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.30x30	85	TM3	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.30x30	85	TM3	C => S	N/A	N/A		Dawson ES et al (2001)
aa1r_human	3.31x31	86	TM3	P => F	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.32x32	87	TM3	V => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.33x33	88	TM3	L => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.36x36	91	TM3	T => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.37x37	92	TM3	Q => A	N/A	N/A		Gao ZG et al (2002)
aa1r_human	3.37x37	92	TM3	Q => A	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	3.39x39	94	TM3	S => A	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	3.39x39	94	TM3	S => T	N/A	N/A		Barbhaiya H et al (1996)
aa1r_human	3.41x41	96	TM3	L => F	N/A	N/A		Rivkees SA et al (1999)
aa1r_human	4.49x49	131	TM4	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	4.49x49	131	TM4	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	45.50x50	169	ECL2	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	45.50x50	169	ECL2	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	6.52x52	251	TM6	H => L	N/A	N/A		Gao ZG et al (2002)
aa1r_human	6.56x56	255	TM6	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	6.56x56	255	TM6	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	6.61x61	260	TM6	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	6.61x61	260	TM6	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human		263	ECL3	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human		263	ECL3	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human		264	ECL3	H => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human		265	ECL3	K => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.31x30	266	TM7	P => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.32x31	267	TM7	S => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.33x32	268	TM7	I => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.34x33	269	TM7	L => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.35x34	270	TM7	T => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.36x35	271	TM7	Y => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.37x36	272	TM7	I => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.38x37	273	TM7	A => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.39x38	274	TM7	I => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.40x39	275	TM7	F => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.41x40	276	TM7	L => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.42x41	277	TM7	T => A	N/A	N/A		Olah ME et al (2000)
aa1r_human	7.42x41	277	TM7	T => A	N/A	N/A		Townsend-Nicholson A et al (1994)
aa1r_human	7.42x41	277	TM7	T => A	N/A	N/A		Dalpiaz A et al (1998)
aa1r_human	7.42x41	277	TM7	T => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.42x41	277	TM7	T => S	N/A	N/A		Townsend-Nicholson A et al (1994)
aa1r_human	7.43x42	278	TM7	H => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.43x42	278	TM7	H => L	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.44x43	279	TM7	G => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.45x45	280	TM7	N => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.46x46	281	TM7	S => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.47x47	282	TM7	A => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.48x48	283	TM7	M => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.49x49	284	TM7	N => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.50x50	285	TM7	P => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.51x51	286	TM7	I => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.52x52	287	TM7	V => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.53x53	288	TM7	Y => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.54x54	289	TM7	A => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.55x55	290	TM7	F => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	7.56x56	291	TM7	R => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	8.47x47	292	H8	I => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	8.48x48	293	H8	Q => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	8.49x49	294	H8	K => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	8.50x50	295	H8	F => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	8.51x51	296	H8	R => C	N/A	N/A		Dawson ES et al (2001)
aa1r_human	8.64x64	309	H8	C => A	N/A	N/A		Gao Z et al (1999)
aa1r_human	8.64x64	309	H8	C => A	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	8.64x64	309	H8	C => A	N/A	N/A		Ferguson G et al (2002)
aa1r_human	8.64x64	309	H8	C => S	N/A	N/A		Scholl DJ et al (2000)
aa1r_human	3.37x37	92	TM3	Q => A	N/A	N/A		Gao ZG et al (2002)
aa1r_human	7.43x42	278	TM7	H => E	N/A	N/A		Palaniappan KK et al (2007)
aa1r_human	7.43x42	278	TM7	H => D	N/A	N/A		Palaniappan KK et al (2007)
aa1r_human	7.42x41	277	TM7	T => E	N/A	N/A		Palaniappan KK et al (2007)
aa1r_human	7.42x41	277	TM7	T => A	N/A	N/A		Palaniappan KK et al (2007)
aa1r_human	7.43x42	278	TM7	H => L	N/A	N/A		Palaniappan KK et al (2007)
aa1r_human	7.43x42	278	TM7	H => A	N/A	N/A		Palaniappan KK et al (2007)
aa1r_human	7.43x42	278	TM7	H => E	N/A	N/A		Prakash NJ et al (1988)
aa1r_human	7.43x42	278	TM7	H => D	N/A	N/A		Prakash NJ et al (1988)
aa1r_human	7.43x42	278	TM7	H => A	N/A	N/A		Prakash NJ et al (1988)
aa1r_human	7.43x42	278	TM7	H => L	N/A	N/A		Prakash NJ et al (1988)
aa1r_human	7.42x41	277	TM7	T => A	N/A	N/A		Prakash NJ et al (1988)
aa1r_human	7.42x41	277	TM7	T => E	N/A	N/A		Prakash NJ et al (1988)
aa1r_human	1.29x29	6	TM1	S => A	No effect	K(d) (Binding - Radioligand saturation)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.29x29	6	TM1	S => A	No effect	K(d) (Binding - Radioligand saturation)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	85.714↑	K(d) (Binding - Radioligand saturation)	CCPA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.143↓	K(d) (Binding - Radioligand saturation)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	7.286↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	933.333↑	K(i) (Binding - Radioligand competition/displacement)	2-chloroadenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	137.037↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	108.333↑	K(i) (Binding - Radioligand competition/displacement)	cyclopentyladenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.953↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.222↓	K(d) (Binding - Radioligand saturation)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.399↓	K(d) (Binding - Radioligand saturation)	CCPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => A	1.053↓	K(i) (Binding - Radioligand competition/displacement)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => L	1.264↓	K(i) (Binding - Radioligand competition/displacement)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	86.508↑	K(i) (Binding - Radioligand competition/displacement)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => A	1.25↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => L	1.767↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.504↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => A	1.408↑	(Functional - cAMP accumulation)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => L	1.139↓	(Functional - cAMP accumulation)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.245↑	(Functional - cAMP accumulation)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => A	1.225↓	(Functional - cAMP accumulation)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => L	1.0	(Functional - cAMP accumulation)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	3.205↓	(Functional - cAMP accumulation)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	42.353↑	K(i) (Binding - Radioligand competition/displacement)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	29.562↑	K(i) (Binding - Radioligand competition/displacement)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	104.889↑	K(i) (Binding - Radioligand competition/displacement)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.08↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.949↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.083↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	83.768↑	K(i) (Binding - Radioligand competition/displacement)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	1.541↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	No effect	EC50 (Functional - [35S]GPTγS binding)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	No effect	EC50 (Functional - [35S]GPTγS binding)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => T	No effect	EC50 (Functional - [35S]GPTγS binding)	8-cyclopentyltheophylline	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => A	1.236↓	EC50 (Functional - [35S]GPTγS binding)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => A	No effect	EC50 (Functional - [35S]GPTγS binding)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => A	1.13↑	EC50 (Functional - [35S]GPTγS binding)	8-cyclopentyltheophylline	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => L	1.164↓	EC50 (Functional - [35S]GPTγS binding)	CPA	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => L	No effect	EC50 (Functional - [35S]GPTγS binding)	DPCPX	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.37x37	14	TM1	G => L	1.232↓	EC50 (Functional - [35S]GPTγS binding)	8-cyclopentyltheophylline	de Ligt RA et al (2005)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	8.85↓	K(d) (Binding - Radioligand competition/displacement)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	15.385↓	K(d) (Binding - Radioligand competition/displacement)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	1.859↓	K(d) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	2.427↓	K(d) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	8.403↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	30.303↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	15.385↓	K(i) (Binding - Radioligand competition/displacement)	2-ClAdo	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	6.667↓	K(i) (Binding - Radioligand competition/displacement)	2-ClAdo	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	3.509↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	11.111↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	40.0↓	K(i) (Binding - Radioligand competition/displacement)	CPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	500.0↓	K(i) (Binding - Radioligand competition/displacement)	CPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	1.442↑	K(i) (Binding - Radioligand competition/displacement)	caffeine	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	Abolished effect	K(i) (Binding - Radioligand competition/displacement)	caffeine	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	29.412↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL48278	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	10.753↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL48278	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	1.078↓	K(i) (Binding - Radioligand competition/displacement)	theophylline	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	Abolished effect	K(i) (Binding - Radioligand competition/displacement)	theophylline	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	Abolished effect	K(i) (Binding - Radioligand competition/displacement)	CHEMBL102859	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	Abolished effect	K(i) (Binding - Radioligand competition/displacement)	CHEMBL102859	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => A	1.045↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.39x39	16	TM1	E => Q	1.499↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.46x46	23	TM1	S => A	No effect	K(d) (Binding - Radioligand saturation)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.46x46	23	TM1	S => A	No effect	K(d) (Binding - Radioligand saturation)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	1.48x48	25	TM1	P => L	3.003↓	K(d) (Binding - Radioligand saturation)	CCPA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.48x48	25	TM1	P => L	1.0	K(d) (Binding - Radioligand saturation)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.48x48	25	TM1	P => L	2.941↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.48x48	25	TM1	P => L	3.922↓	K(i) (Binding - Radioligand competition/displacement)	2-chloroadenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.48x48	25	TM1	P => L	3.509↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.48x48	25	TM1	P => L	62.5↓	K(i) (Binding - Radioligand competition/displacement)	cyclopentyladenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.48x48	25	TM1	P => L	1.499↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.54x54	31	TM1	I => C	1.167↓	K(d) (Binding - Radioligand saturation)	CCPA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	1.54x54	31	TM1	I => C	1.143↓	K(d) (Binding - Radioligand saturation)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	2.41x41	46	TM2	C => S	1.095↑	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	2.41x41	46	TM2	C => A	1.25↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	2.41x41	46	TM2	C => S	1.159↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	2.41x41	46	TM2	C => A	1.685↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	2.41x41	46	TM2	C => S	1.23↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	2.41x41	46	TM2	C => A	1.608↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	2.41x41	46	TM2	C => S	1.289↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	2.41x41	46	TM2	C => A	1.328↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	2.45x45	50	TM2	S => A	1.835↓	K(d) (Binding - Radioligand competition/displacement)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.45x45	50	TM2	S => A	1.4↑	K(d) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.45x45	50	TM2	S => A	No effect	K(d) (Binding - Radioligand saturation)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.45x45	50	TM2	S => A	No effect	K(d) (Binding - Radioligand saturation)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	3.0↑	K(d) (Binding - Radioligand competition/displacement)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	1.4↑	K(d) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	714.286↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	56.0↑	K(i) (Binding - Radioligand competition/displacement)	2-ClAdo	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	308.333↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	135.417↑	K(i) (Binding - Radioligand competition/displacement)	CPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	1.19↑	K(i) (Binding - Radioligand competition/displacement)	caffeine	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	3.155↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL48278	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	1.481↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	1.499↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL102859	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.50x50	55	TM2	D => A	1.375↑	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	2.60x59	65	TM2	L => F	1.0	K(d) (Binding - Radioligand saturation)	CCPA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	2.60x59	65	TM2	L => F	1.0	K(d) (Binding - Radioligand saturation)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.25x25	80	TM3	C => S	Abolished effect	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.25x25	80	TM3	C => A	Abolished effect	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.27x27	82	TM3	M => F	1.167↓	K(d) (Binding - Radioligand saturation)	CCPA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.27x27	82	TM3	M => F	1.143↓	K(d) (Binding - Radioligand saturation)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.30x30	85	TM3	C => S	1.065↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.30x30	85	TM3	C => A	1.282↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.30x30	85	TM3	C => S	1.012↓	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.30x30	85	TM3	C => A	1.316↓	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.30x30	85	TM3	C => S	12.5↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.30x30	85	TM3	C => A	1.321↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.30x30	85	TM3	C => S	4.0↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.30x30	85	TM3	C => A	1.754↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	3.31x31	86	TM3	P => F	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NECA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.31x31	86	TM3	P => F	11.111↓	K(i) (Binding - Radioligand competition/displacement)	2-chloroadenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.31x31	86	TM3	P => F	125.0↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.31x31	86	TM3	P => F	100.0↓	K(i) (Binding - Radioligand competition/displacement)	cyclopentyladenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.31x31	86	TM3	P => F	1.375↑	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.32x32	87	TM3	V => A	1.214↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.32x32	87	TM3	V => A	1.3↓	K(i) (Binding - Radioligand competition/displacement)	2-chloroadenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.32x32	87	TM3	V => A	71.429↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.32x32	87	TM3	V => A	1.018↑	K(i) (Binding - Radioligand competition/displacement)	cyclopentyladenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.32x32	87	TM3	V => A	3.067↓	K(i) (Binding - Radioligand competition/displacement)	CHEMBL48278	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.33x33	88	TM3	L => A	29.412↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.33x33	88	TM3	L => A	1.1↓	K(i) (Binding - Radioligand competition/displacement)	2-chloroadenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.33x33	88	TM3	L => A	500.0↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.33x33	88	TM3	L => A	76.923↓	K(i) (Binding - Radioligand competition/displacement)	cyclopentyladenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.33x33	88	TM3	L => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CHEMBL48278	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.36x36	91	TM3	T => A	142.857↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.36x36	91	TM3	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	2-chloroadenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.36x36	91	TM3	T => A	200.0↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.36x36	91	TM3	T => A	17.241↓	K(i) (Binding - Radioligand competition/displacement)	cyclopentyladenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.36x36	91	TM3	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CHEMBL48278	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.37x37	92	TM3	Q => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NECA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.37x37	92	TM3	Q => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	2-chloroadenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.37x37	92	TM3	Q => A	N/A	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.37x37	92	TM3	Q => A	23.256↓	K(i) (Binding - Radioligand competition/displacement)	cyclopentyladenosine	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.37x37	92	TM3	Q => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CHEMBL48278	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	3.38x38	93	TM3	S => A	1.667↓	K(d) (Binding - Radioligand competition/displacement)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	3.38x38	93	TM3	S => A	1.75↑	K(d) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	3.38x38	93	TM3	S => A	No effect	K(d) (Binding - Radioligand saturation)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	3.38x38	93	TM3	S => A	No effect	K(d) (Binding - Radioligand saturation)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	3.39x39	94	TM3	S => A	Abolished effect	K(d) (Binding - Radioligand competition/displacement)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	3.39x39	94	TM3	S => A	Abolished effect	K(d) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.43x43	125	TM4	A => K	1.167↓	K(d) (Binding - Radioligand saturation)	CCPA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	4.43x43	125	TM4	A => K	1.0	K(d) (Binding - Radioligand saturation)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	4.49x49	131	TM4	C => S	1.033↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.49x49	131	TM4	C => A	1.011↑	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.49x49	131	TM4	C => S	1.391↓	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.49x49	131	TM4	C => A	1.153↓	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.49x49	131	TM4	C => S	1.014↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.49x49	131	TM4	C => A	2.096↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.49x49	131	TM4	C => S	1.37↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.49x49	131	TM4	C => A	1.395↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.53x53	135	TM4	S => A	1.0	K(d) (Binding - Radioligand competition/displacement)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.53x53	135	TM4	S => A	1.029↓	K(d) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.53x53	135	TM4	S => A	No effect	K(d) (Binding - Radioligand saturation)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.53x53	135	TM4	S => A	No effect	K(d) (Binding - Radioligand saturation)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.59x59	141	TM4	T => A	1.5↑	K(d) (Binding - Radioligand competition/displacement)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.59x59	141	TM4	T => A	1.057↓	K(d) (Binding - Radioligand competition/displacement)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.59x59	141	TM4	T => A	No effect	K(d) (Binding - Radioligand saturation)	CCPA	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.59x59	141	TM4	T => A	No effect	K(d) (Binding - Radioligand saturation)	DPCPX	Barbhaiya H et al (1996)	Jespers W et al (2018)
aa1r_human	4.62x62	144	TM4	F => L	1.0	K(d) (Binding - Radioligand saturation)	CCPA	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human	4.62x62	144	TM4	F => L	1.143↓	K(d) (Binding - Radioligand saturation)	DPCPX	Rivkees SA et al (1999)	Jespers W et al (2018)
aa1r_human		150	ECL2	S => A	2.306↑	K(d) (Binding - Radioligand saturation)	I-ABA	Kennedy DP et al (2014)	Jespers W et al (2018)
aa1r_human		153	ECL2	E => A	4.292↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		153	ECL2	E => A	Decreased effect	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		154	ECL2	R => A	1.2↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		154	ECL2	R => A	1.006↑	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		154	ECL2	R => A	1.044↓	IC50 (Binding - Radioligand competition/displacement)	PD81723	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		156	ECL2	W => A	1.037↑	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		156	ECL2	W => A	2.045↓	IC50 (Binding - Radioligand competition/displacement)	PD81723	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		159	ECL2	N => A	3.497↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		159	ECL2	N => A	1.018↓	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		159	ECL2	N => A	1.078↑	IC50 (Binding - Radioligand competition/displacement)	PD81723	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		160	ECL2	G => A	7.092↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		160	ECL2	G => A	Decreased effect	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		161	ECL2	S => A	4.098↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		161	ECL2	S => A	1.012↓	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		161	ECL2	S => A	1.087↓	IC50 (Binding - Radioligand competition/displacement)	PD81723	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		162	ECL2	M => A	1.2↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		162	ECL2	M => A	1.285↑	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		162	ECL2	M => A	1.255↑	IC50 (Binding - Radioligand competition/displacement)	PD81723	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		162	ECL2	M => A	2.372↑	K(d) (Binding - Radioligand saturation)	I-ABA	Kennedy DP et al (2014)	Jespers W et al (2018)
aa1r_human		163	ECL2	G => S	20.833↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		163	ECL2	G => A	Decreased effect	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		164	ECL2	E => A	1.499↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		164	ECL2	E => A	1.149↓	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		164	ECL2	E => A	1.19↑	IC50 (Binding - Radioligand competition/displacement)	PD81723	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		165	ECL2	P => A	6.098↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		165	ECL2	P => A	Decreased effect	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		166	ECL2	V => A	6.41↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		166	ECL2	V => A	Decreased effect	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		167	ECL2	I => A	45.455↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		167	ECL2	I => A	Decreased effect	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human	45.50x50	169	ECL2	C => S	Abolished effect	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	45.50x50	169	ECL2	C => A	Abolished effect	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => A	4.0↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => A	Decreased effect	IC50 (Binding - Radioligand competition/displacement)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	1.3↓	(Functional - cAMP accumulation)	DPCPX	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	6.56x56	255	TM6	C => S	1.163↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.56x56	255	TM6	C => A	1.152↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.56x56	255	TM6	C => S	1.249↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.56x56	255	TM6	C => A	1.071↓	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.56x56	255	TM6	C => S	1.364↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.56x56	255	TM6	C => A	2.028↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.56x56	255	TM6	C => S	1.622↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.56x56	255	TM6	C => A	1.032↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => S	1.163↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => A	1.391↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => S	1.617↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => A	2.34↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => S	2.114↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => A	1.897↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => S	1.869↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => A	1.176↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	6.61x61	260	TM6	C => A	1.401↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		261	ECL3	P => A	2.5↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		262	ECL3	S => A	1.901↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => S	1.488↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => A	2.11↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => S	1.975↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => A	1.046↓	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => S	1.682↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => A	1.138↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => S	1.355↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => A	1.364↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human		263	ECL3	C => A	1.0	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		264	ECL3	H => C	1.096↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		264	ECL3	H => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		264	ECL3	H => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		264	ECL3	H => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		264	ECL3	H => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		264	ECL3	H => A	1.6↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human		265	ECL3	K => C	1.476↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		265	ECL3	K => C	2.433↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		265	ECL3	K => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		265	ECL3	K => C	6.903↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		265	ECL3	K => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human		265	ECL3	K => A	1.799↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human	7.31x30	266	TM7	P => C	1.278↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.31x30	266	TM7	P => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.31x30	266	TM7	P => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.31x30	266	TM7	P => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.31x30	266	TM7	P => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.31x30	266	TM7	P => A	3.597↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human	7.32x31	267	TM7	S => C	1.041↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.32x31	267	TM7	S => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.32x31	267	TM7	S => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.32x31	267	TM7	S => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.32x31	267	TM7	S => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.32x31	267	TM7	S => A	2.198↓	EC50 (Functional - Other)	CPA	Peeters MC et al (2012)	Jespers W et al (2018)
aa1r_human	7.33x32	268	TM7	I => C	1.372↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.33x32	268	TM7	I => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.33x32	268	TM7	I => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.33x32	268	TM7	I => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.33x32	268	TM7	I => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.34x33	269	TM7	L => C	1.305↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.34x33	269	TM7	L => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.34x33	269	TM7	L => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.34x33	269	TM7	L => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.34x33	269	TM7	L => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => C	1.0	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => C	3.367↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => C	3.443↑	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => C	4.548↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.36x35	271	TM7	Y => C	2.105↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.36x35	271	TM7	Y => C	5.988↓	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.36x35	271	TM7	Y => C	1.771↑	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.36x35	271	TM7	Y => C	2.817↓	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.36x35	271	TM7	Y => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.37x36	272	TM7	I => C	1.24↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.37x36	272	TM7	I => C	4.55↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.37x36	272	TM7	I => C	1.714↑	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.37x36	272	TM7	I => C	2.935↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.37x36	272	TM7	I => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.38x37	273	TM7	A => C	1.138↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.38x37	273	TM7	A => C	16.133↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.38x37	273	TM7	A => C	6.157↑	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.38x37	273	TM7	A => C	13.806↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.38x37	273	TM7	A => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.39x38	274	TM7	I => C	2.865↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.39x38	274	TM7	I => C	14.183↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.39x38	274	TM7	I => C	11.971↑	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.39x38	274	TM7	I => C	17.516↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.39x38	274	TM7	I => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.40x39	275	TM7	F => C	1.824↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.40x39	275	TM7	F => C	6.667↓	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.40x39	275	TM7	F => C	3.891↓	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.40x39	275	TM7	F => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.40x39	275	TM7	F => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.41x40	276	TM7	L => C	1.008↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.41x40	276	TM7	L => C	4.1↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.41x40	276	TM7	L => C	1.229↓	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.41x40	276	TM7	L => C	3.387↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.41x40	276	TM7	L => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => S	1.376↓	K(d) (Binding - Radioligand saturation)	DPCPX	Townsend-Nicholson A et al (1994)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	2.0↑	K(d) (Binding - Radioligand saturation)	DPCPX	Townsend-Nicholson A et al (1994)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => S	4.386↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Townsend-Nicholson A et al (1994)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	3.846↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Townsend-Nicholson A et al (1994)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => S	7.463↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Townsend-Nicholson A et al (1994)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	6.849↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Townsend-Nicholson A et al (1994)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => S	115.823↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Townsend-Nicholson A et al (1994)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	2.288↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Townsend-Nicholson A et al (1994)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	1.087↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	N/A	K(i) (Binding - Radioligand competition/displacement)	CPA	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	2.075↓	K(i) (Binding - Radioligand competition/displacement)	8BCPA	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	3.534↓	K(i) (Binding - Radioligand competition/displacement)	8-cyclopentyltheophylline	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	1.195↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	111.111↓	K(i) (Binding - Radioligand competition/displacement)	CPA	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	4.673↓	K(i) (Binding - Radioligand competition/displacement)	8BCPA	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	2.227↓	K(i) (Binding - Radioligand competition/displacement)	8-cyclopentyltheophylline	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Abolished effect	K(i) (Binding - Radioligand competition/displacement)	CPA	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	No response	K(i) (Binding - Radioligand competition/displacement)	8BCPA	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Abolished effect	K(i) (Binding - Radioligand competition/displacement)	CPA	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Abolished effect	K(i) (Binding - Radioligand competition/displacement)	8BCPA	Dalpiaz A et al (1998)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	8.0↑	K(d) (Binding - Radioligand saturation)	DPCPX	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	17.6↑	K(d) (Binding - Other)	DPCPX	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	3.238↑	K(d) (Binding - Other)	DPCPX	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	N/A	K(i) (Binding - Radioligand competition/displacement)	CPA	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	N/A	K(i) (Binding - Radioligand competition/displacement)	NECA	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	500.0↓	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	N/A	K(i) (Binding - Other)	CPA	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	N/A	K(i) (Binding - Other)	NECA	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	N/A	K(i) (Binding - Other)	R-PIA	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	1.333↑	(Functional - cAMP accumulation)	PD81723	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	1.429↑	(Functional - cAMP accumulation)	CPA	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	20.0↑	(Functional - cAMP accumulation)	PD81723	Kourounakis A et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => C	3.543↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => C	1.818↓	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => C	2.058↓	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => C	9.226↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	2.116↑	K(d) (Binding - Radioligand saturation)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	2.169↓	K(d) (Binding - Radioligand saturation)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	4.065↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	1.286↑	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	2.532↓	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	1.353↓	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	adenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	adenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	No effect	K(i) (Binding - Radioligand competition/displacement)	5'-Deoxy-5'-aminoadenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	No effect	K(i) (Binding - Radioligand competition/displacement)	5'-Deoxy-5'-aminoadenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	No effect	K(i) (Binding - Radioligand competition/displacement)	CID74083098	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	No effect	K(i) (Binding - Radioligand competition/displacement)	CID74083098	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	No effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	No effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID303988	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID303988	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	11.494↓	K(i) (Binding - Radioligand competition/displacement)	CCPA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CCPA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	No effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID73014720	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID73014720	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	No effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID 85129620	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID 85129620	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NECA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NECA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	Cid13307390	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	Cid13307390	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	No effect	K(i) (Binding - Radioligand competition/displacement)	CID75022540	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID75022540	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.42x41	277	TM7	T => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID73088153	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => C	1.016↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => C	14.067↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => C	11.629↑	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => C	28.226↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	1.992↓	K(d) (Binding - Radioligand saturation)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	1.312↓	K(d) (Binding - Radioligand saturation)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	2.092↓	K(d) (Binding - Radioligand saturation)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	1.661↓	K(d) (Binding - Radioligand saturation)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	8.0↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	11.111↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	8.85↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	7.752↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	35.714↓	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	32.258↓	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	47.619↓	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	26.316↓	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	adenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	adenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	adenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	adenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	5'-Deoxy-5'-aminoadenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	No effect	K(i) (Binding - Radioligand competition/displacement)	5'-Deoxy-5'-aminoadenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	5'-Deoxy-5'-aminoadenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Increased effect	K(i) (Binding - Radioligand competition/displacement)	5'-Deoxy-5'-aminoadenosine	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID74083098	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID74083098	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID74083098	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID74083098	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID303988	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID303988	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID303988	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	CID303988	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	No effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	No effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	1.969↓	K(i) (Binding - Radioligand competition/displacement)	CCPA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	1.639↓	K(i) (Binding - Radioligand competition/displacement)	CCPA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	2.294↓	K(i) (Binding - Radioligand competition/displacement)	CCPA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	1.344↓	K(i) (Binding - Radioligand competition/displacement)	CCPA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	26.786↑	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	33.333↑	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	26.316↑	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	27.273↑	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	29.524↑	K(i) (Binding - Radioligand competition/displacement)	CID73014720	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	25.833↑	K(i) (Binding - Radioligand competition/displacement)	CID73014720	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	28.182↑	K(i) (Binding - Radioligand competition/displacement)	CID73014720	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	21.379↑	K(i) (Binding - Radioligand competition/displacement)	CID73014720	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Decreased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID 85129620	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID 85129620	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID 85129620	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	6.061↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	5.319↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	5.495↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	5.495↓	K(i) (Binding - Radioligand competition/displacement)	NECA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	Cid13307390	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	Cid13307390	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	Cid13307390	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Increased effect	K(i) (Binding - Radioligand competition/displacement)	Cid13307390	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID75022540	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID75022540	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => A	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID75022540	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => L	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID75022540	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => E	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID73088153	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	K(i) (Binding - Radioligand competition/displacement)	CID73088153	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Increased effect	EC50 (Functional - Ca2+ accumulation)	CID75022540	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Abolished effect	EC50 (Functional - Ca2+ accumulation)	CPA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	Abolished effect	EC50 (Functional - Ca2+ accumulation)	NECA	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	No effect	EC50 (Functional - Ca2+ accumulation)	NONAME	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.43x42	278	TM7	H => D	No effect	EC50 (Functional - Ca2+ accumulation)	CID73019726	Palaniappan KK et al (2007)	Jespers W et al (2018)
aa1r_human	7.44x43	279	TM7	G => C	1.33↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.44x43	279	TM7	G => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.44x43	279	TM7	G => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.44x43	279	TM7	G => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.44x43	279	TM7	G => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.45x45	280	TM7	N => C	1.025↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.45x45	280	TM7	N => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.45x45	280	TM7	N => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.45x45	280	TM7	N => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.45x45	280	TM7	N => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.46x46	281	TM7	S => C	1.097↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.46x46	281	TM7	S => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.46x46	281	TM7	S => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.46x46	281	TM7	S => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.46x46	281	TM7	S => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.47x47	282	TM7	A => C	1.148↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.47x47	282	TM7	A => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.47x47	282	TM7	A => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.47x47	282	TM7	A => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.47x47	282	TM7	A => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.48x48	283	TM7	M => C	1.305↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.48x48	283	TM7	M => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.48x48	283	TM7	M => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.48x48	283	TM7	M => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.48x48	283	TM7	M => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.49x49	284	TM7	N => C	1.771↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.49x49	284	TM7	N => C	1.55↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.49x49	284	TM7	N => C	2.914↑	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.49x49	284	TM7	N => C	5.839↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.49x49	284	TM7	N => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.50x50	285	TM7	P => C	1.127↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.50x50	285	TM7	P => C	1.017↓	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.50x50	285	TM7	P => C	1.458↓	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.50x50	285	TM7	P => C	1.968↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.50x50	285	TM7	P => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.51x51	286	TM7	I => C	1.363↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.51x51	286	TM7	I => C	1.091↓	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.51x51	286	TM7	I => C	1.706↓	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.51x51	286	TM7	I => C	2.387↓	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.51x51	286	TM7	I => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.52x52	287	TM7	V => C	1.121↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.52x52	287	TM7	V => C	1.417↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.52x52	287	TM7	V => C	1.522↓	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.52x52	287	TM7	V => C	2.871↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.52x52	287	TM7	V => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.53x53	288	TM7	Y => C	1.699↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.53x53	288	TM7	Y => C	3.4↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.53x53	288	TM7	Y => C	2.329↑	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.53x53	288	TM7	Y => C	5.0↑	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.53x53	288	TM7	Y => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.54x54	289	TM7	A => C	1.117↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.54x54	289	TM7	A => C	1.067↑	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.54x54	289	TM7	A => C	3.497↓	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.54x54	289	TM7	A => C	2.584↓	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.54x54	289	TM7	A => C	N/A	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.55x55	290	TM7	F => C	1.129↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.55x55	290	TM7	F => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.55x55	290	TM7	F => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.55x55	290	TM7	F => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.55x55	290	TM7	F => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.56x56	291	TM7	R => C	1.161↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.56x56	291	TM7	R => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.56x56	291	TM7	R => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.56x56	291	TM7	R => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	7.56x56	291	TM7	R => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.47x47	292	H8	I => C	1.307↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.47x47	292	H8	I => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.47x47	292	H8	I => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.47x47	292	H8	I => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.47x47	292	H8	I => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.48x48	293	H8	Q => C	1.033↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.48x48	293	H8	Q => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.48x48	293	H8	Q => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.48x48	293	H8	Q => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.48x48	293	H8	Q => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.49x49	294	H8	K => C	1.121↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.49x49	294	H8	K => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.49x49	294	H8	K => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.49x49	294	H8	K => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.49x49	294	H8	K => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.50x50	295	H8	F => C	1.145↓	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.50x50	295	H8	F => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.50x50	295	H8	F => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.50x50	295	H8	F => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.50x50	295	H8	F => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.51x51	296	H8	R => C	1.117↑	K(d) (Binding - Radioligand saturation)	DPCPX	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.51x51	296	H8	R => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSEA	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.51x51	296	H8	R => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTSET	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.51x51	296	H8	R => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-TEAH	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.51x51	296	H8	R => C	No effect	Specific binding (Binding - Radioligand competition/displacement)	MTS-EDANS	Dawson ES et al (2001)	Jespers W et al (2018)
aa1r_human	8.64x64	309	H8	C => S	1.13↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	8.64x64	309	H8	C => A	1.13↓	K(d) (Binding - Radioligand saturation)	DPCPX	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	8.64x64	309	H8	C => S	1.176↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	8.64x64	309	H8	C => A	1.339↑	K(i) (Binding - Radioligand competition/displacement)	theophylline	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	8.64x64	309	H8	C => S	1.423↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	8.64x64	309	H8	C => A	1.194↑	K(i) (Binding - Radioligand competition/displacement)	NECA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	8.64x64	309	H8	C => S	1.767↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	8.64x64	309	H8	C => A	1.585↑	K(i) (Binding - Radioligand competition/displacement)	R-PIA	Scholl DJ et al (2000)	Jespers W et al (2018)
aa1r_human	4.62x62	144	TM4	F => A	2.089↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	4.63x63	145	TM4	G => A	1.621↓	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		146	ECL2	W => A	1.202↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		147	ECL2	N => A	5.495↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		148	ECL2	N => A	3.311↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		149	ECL2	L => A	2.291↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		153	ECL2	E => A	1.995↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		154	ECL2	R => A	1.202↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		156	ECL2	W => A	1.024↓	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		159	ECL2	N => A	1.349↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		160	ECL2	G => A	2.239↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		161	ECL2	S => A	5.888↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		165	ECL2	P => A	2.399↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		166	ECL2	V => A	3.467↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		167	ECL2	I => A	6.31↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		168	ECL2	K => A	2.818↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => A	3.89↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		172	ECL2	E => A	3.311↓	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		173	ECL2	K => A	6.166↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		174	ECL2	V => A	3.162↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		175	ECL2	I => A	12.023↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	5.34x36	176	TM5	S => A	2.344↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	5.35x37	177	TM5	M => A	2.089↑	pK(b) (Binding - Radioligand competition/displacement)	PD81723	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	4.62x62	144	TM4	F => A	1.479↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	4.63x63	145	TM4	G => A	2.137↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		146	ECL2	W => A	1.0	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		147	ECL2	N => A	1.479↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		148	ECL2	N => A	1.175↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		149	ECL2	L => A	1.047↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		153	ECL2	E => A	1.862↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		154	ECL2	R => A	1.82↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		156	ECL2	W => A	1.862↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		159	ECL2	N => A	1.905↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		160	ECL2	G => A	2.042↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		161	ECL2	S => A	1.047↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		165	ECL2	P => A	1.995↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		166	ECL2	V => A	1.413↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		167	ECL2	I => A	1.778↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		168	ECL2	K => A	1.445↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => A	1.175↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		172	ECL2	E => A	2.457↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		173	ECL2	K => A	1.905↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		174	ECL2	V => A	1.82↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		175	ECL2	I => A	1.514↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	5.34x36	176	TM5	S => A	1.513↓	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	5.35x37	177	TM5	M => A	1.096↑	pK(b) (Binding - Radioligand competition/displacement)	VPC171	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	4.62x62	144	TM4	F => A	1.148↑	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	4.63x63	145	TM4	G => A	1.479↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		146	ECL2	W => A	1.585↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		147	ECL2	N => A	1.23↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		148	ECL2	N => A	1.548↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		149	ECL2	L => A	1.514↑	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		153	ECL2	E => A	1.0	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		154	ECL2	R => A	1.289↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		156	ECL2	W => A	1.259↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		159	ECL2	N => A	4.082↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		160	ECL2	G => A	1.349↑	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		161	ECL2	S => A	3.236↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		165	ECL2	P => A	1.318↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		166	ECL2	V => A	1.318↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		167	ECL2	I => A	5.618↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		168	ECL2	K => A	1.122↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => A	1.175↑	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	45.52x52	171	ECL2	F => A	Abolished effect	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		172	ECL2	E => A	3.236↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		173	ECL2	K => A	1.096↑	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		174	ECL2	V => A	1.122↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		175	ECL2	I => A	5.236↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	5.34x36	176	TM5	S => A	1.23↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	5.35x37	177	TM5	M => A	6.024↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		265	ECL3	K => A	1.548↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => A	2.188↓	pK(d) (Binding - Radioligand competition/displacement)	DPCPX	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	4.62x62	144	TM4	F => A	1.072↑	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	4.63x63	145	TM4	G => A	1.621↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		146	ECL2	W => A	2.457↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		147	ECL2	N => A	1.548↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		148	ECL2	N => A	1.288↑	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		149	ECL2	L => A	2.239↑	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		153	ECL2	E => A	1.024↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		154	ECL2	R => A	1.175↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		156	ECL2	W => A	1.23↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		159	ECL2	N => A	4.367↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		160	ECL2	G => A	1.622↑	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		161	ECL2	S => A	3.086↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		165	ECL2	P => A	1.381↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		166	ECL2	V => A	1.381↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		167	ECL2	I => A	7.092↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		168	ECL2	K => A	1.445↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => A	2.342↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	45.52x52	171	ECL2	F => A	Abolished effect	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		172	ECL2	E => A	5.618↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		173	ECL2	K => A	1.479↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		174	ECL2	V => A	1.35↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		175	ECL2	I => A	10.753↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	5.34x36	176	TM5	S => A	1.621↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	5.35x37	177	TM5	M => A	6.024↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human		265	ECL3	K => A	1.779↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => A	6.757↓	pK(i) (Binding - Radioligand competition/displacement)	NECA	Nguyen AT et al (2016)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.15↑	K(i) (Binding - Radioligand competition/displacement)	ZM241385	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	2.16↑	K(i) (Binding - Radioligand competition/displacement)	ZM241385	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	1.55↑	K(i) (Binding - Radioligand competition/displacement)	ZM241385	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	4.0↓	K(i) (Binding - Radioligand competition/displacement)	ZM241385	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.01↑	K(i) (Binding - Radioligand competition/displacement)	SCH 58261	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	2.83↑	K(i) (Binding - Radioligand competition/displacement)	SCH 58261	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	1.97↑	K(i) (Binding - Radioligand competition/displacement)	SCH 58261	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	1.724↓	K(i) (Binding - Radioligand competition/displacement)	SCH 58261	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.58↑	K(i) (Binding - Radioligand competition/displacement)	SCH442416	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	1.19↓	K(i) (Binding - Radioligand competition/displacement)	SCH442416	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	1.71↑	K(i) (Binding - Radioligand competition/displacement)	SCH442416	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	3.333↓	K(i) (Binding - Radioligand competition/displacement)	SCH442416	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.149↓	K(i) (Binding - Radioligand competition/displacement)	istradefylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	1.34↑	K(i) (Binding - Radioligand competition/displacement)	istradefylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	1.15↑	K(i) (Binding - Radioligand competition/displacement)	istradefylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	4.545↓	K(i) (Binding - Radioligand competition/displacement)	istradefylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.15↑	K(i) (Binding - Radioligand competition/displacement)	PSB36	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	1.73↑	K(i) (Binding - Radioligand competition/displacement)	PSB36	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	1.515↓	K(i) (Binding - Radioligand competition/displacement)	PSB36	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	4.52↑	K(i) (Binding - Radioligand competition/displacement)	PSB36	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.08↑	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	1.11↑	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	1.235↓	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	3.24↑	K(i) (Binding - Radioligand competition/displacement)	DPCPX	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.0	K(i) (Binding - Radioligand competition/displacement)	rolofylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	1.65↑	K(i) (Binding - Radioligand competition/displacement)	rolofylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	2.857↓	K(i) (Binding - Radioligand competition/displacement)	rolofylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	3.39↑	K(i) (Binding - Radioligand competition/displacement)	rolofylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	8.56↑	K(i) (Binding - Radioligand competition/displacement)	derenofylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	1.45↑	K(i) (Binding - Radioligand competition/displacement)	derenofylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	1.86↑	K(i) (Binding - Radioligand competition/displacement)	derenofylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	2.16↑	K(i) (Binding - Radioligand competition/displacement)	derenofylline	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.02↑	K(i) (Binding - Radioligand competition/displacement)	xanthine amine congener	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	1.84↑	K(i) (Binding - Radioligand competition/displacement)	xanthine amine congener	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	1.282↓	K(i) (Binding - Radioligand competition/displacement)	xanthine amine congener	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	1.111↓	K(i) (Binding - Radioligand competition/displacement)	xanthine amine congener	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.57x56	62	TM2	V => A	1.44↑	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	2.65x64	70	TM2	N => S	1.85↑	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	45.51x51	170	ECL2	E => L	2.13↑	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	1.333↓	K(i) (Binding - Radioligand competition/displacement)	CGS 15943	Cheng RKY et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	7.937↓	pK(i) (Binding - Radioligand competition/displacement)	DPCPX	Glukhova A et al (2017)	Jespers W et al (2018)
aa1r_human	7.35x34	270	TM7	T => M	1.585↑	pK(i) (Binding - Radioligand competition/displacement)	SCH 58261	Glukhova A et al (2017)	Jespers W et al (2018)
Protein name	Generic number	Segment	Position	Mutation	FoldChange or Qual	Exp Type	Ligand	Reference	Review

Residue

Diagrams

Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A

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Residue Table

GPCRdb(A)	GPCRdb(A)	A₁ receptor
TM1
1x29	1.29x29	S6
1x37	1.37x37	G14
1x39	1.39x39	E16
1x46	1.46x46	S23
1x48	1.48x48	P25
1x54	1.54x54	I31
TM2
2x41	2.41x41	C46
2x45	2.45x45	S50
2x50	2.50x50	D55
2x56	2.57x56	V62
2x59	2.60x59	L65
2x64	2.65x64	N70
TM3
3x25	3.25x25	C80
3x27	3.27x27	M82
3x30	3.30x30	C85
3x31	3.31x31	P86
3x32	3.32x32	V87
3x33	3.33x33	L88
3x36	3.36x36	T91
3x37	3.37x37	Q92
3x38	3.38x38	S93
3x39	3.39x39	S94
3x41	3.41x41	L96
TM4
4x43	4.43x43	A125
4x49	4.49x49	C131
4x53	4.53x53	S135
4x59	4.59x59	T141
4x62	4.62x62	F144
4x63	4.63x63	G145
TM5
5x36	5.34x36	S176
5x37	5.35x37	M177
TM6
6x52	6.52x52	H251
6x56	6.56x56	C255
6x61	6.61x61	C260
TM7
7x30	7.31x30	P266
7x31	7.32x31	S267
7x32	7.33x32	I268
7x33	7.34x33	L269
7x34	7.35x34	T270
7x35	7.36x35	Y271
7x36	7.37x36	I272
7x37	7.38x37	A273
7x38	7.39x38	I274
7x39	7.40x39	F275
7x40	7.41x40	L276
7x41	7.42x41	T277
7x42	7.43x42	H278
7x43	7.44x43	G279
7x45	7.45x45	N280
7x46	7.46x46	S281
7x47	7.47x47	A282
7x48	7.48x48	M283
7x49	7.49x49	N284
7x50	7.50x50	P285
7x51	7.51x51	I286
7x52	7.52x52	V287
7x53	7.53x53	Y288
7x54	7.54x54	A289
7x55	7.55x55	F290
7x56	7.56x56	R291
H8
8x47	8.47x47	I292
8x48	8.48x48	Q293
8x49	8.49x49	K294
8x50	8.50x50	F295
8x51	8.51x51	R296
8x64	8.64x64	C309

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