Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
aa2br_human 167 ECL2 C => Y 1.381↓ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 148 ECL2 D => G 1.202↑ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 6.60x60 259 TM6 F => S 22.222↓ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 34.53x53 113 ICL2 Y => F 32.258↓ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 5.71x71 215 TM5 R => H 1.658↓ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 1.54x54 29 TM1 C => R Abolished pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 2.56x551 59 TM2 F => L 1.413↑ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 4.50x50 130 TM4 W => C Abolished pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 4.61x61 141 TM4 F => L 3.311↑ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 5.58x58 202 TM5 Y => C 3.086↓ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 6.50x50 249 TM6 P => L Abolished pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 8.63x63 310 H8 L => P 2.63↑ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 8.63x63 310 H8 L => F 1.023↑ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 8.63x63 310 H8 L => I 2.457↓ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 8.68x68 315 H8 V => G 1.259↑ pEC50 (Functional - Other) NECA Wang X et al (2020)
aa2br_human 6.60x60 259 TM6 F => S 6.024↓ pEC50 (Functional - Other) BAY 60-6583 Wang X et al (2020)
aa2br_human 34.53x53 113 ICL2 Y => F 9.524↓ pEC50 (Functional - Other) BAY 60-6583 Wang X et al (2020)
aa2br_human 1.54x54 29 TM1 C => R Abolished pEC50 (Functional - Other) BAY 60-6583 Wang X et al (2020)
aa2br_human 4.50x50 130 TM4 W => C Abolished pEC50 (Functional - Other) BAY 60-6583 Wang X et al (2020)
aa2br_human 4.61x61 141 TM4 F => L 1.413↑ pEC50 (Functional - Other) BAY 60-6583 Wang X et al (2020)
aa2br_human 5.58x58 202 TM5 Y => C 1.905↓ pEC50 (Functional - Other) BAY 60-6583 Wang X et al (2020)
aa2br_human 6.50x50 249 TM6 P => L Abolished pEC50 (Functional - Other) BAY 60-6583 Wang X et al (2020)
aa2br_human 8.63x63 310 H8 L => P 2.137↓ pEC50 (Functional - Other) BAY 60-6583 Wang X et al (2020)
aa2br_human 4.61x61 141 TM4 F => L 2.513↓ pK(b) (Functional - Other) PSB603 Wang X et al (2020)
aa2br_human 5.58x58 202 TM5 Y => C Abolished pK(b) (Functional - Other) PSB603 Wang X et al (2020)
aa2br_human 8.63x63 310 H8 L => P 1.585↓ pK(b) (Functional - Other) PSB603 Wang X et al (2020)
aa2br_human 4.61x61 141 TM4 F => L N/A pIC50 (Functional - Other) ZM-241385 Wang X et al (2020)
aa2br_human 5.58x58 202 TM5 Y => C N/A pIC50 (Functional - Other) ZM-241385 Wang X et al (2020)
aa2br_human 8.63x63 310 H8 L => P N/A pIC50 (Functional - Other) ZM-241385 Wang X et al (2020)
aa2br_human 3.25x25 78 TM3 C => S N/A EC50 (cAMP accumulation) NECA Schiedel AC et al (2011)
aa2br_human 3.25x25 78 TM3 C => S Abolished IC50 (binding) (radioligand binding) NECA Schiedel AC et al (2011)
aa2br_human 3.25x25 78 TM3 C => S Abolished IC50 (binding) (radioligand binding) PSB-603 Schiedel AC et al (2011)
aa2br_human 3.25x25 78 TM3 C => S N/A EC50 (cAMP accumulation) BAY60-6583 Schiedel AC et al (2011)
aa2br_human 154 ECL2 C => S 4.348↓ EC50 (cAMP accumulation) NECA Schiedel AC et al (2011)
aa2br_human 154 ECL2 C => S 1.066↑ IC50 (binding) (radioligand binding) NECA Schiedel AC et al (2011)
aa2br_human 154 ECL2 C => S 7.937↓ IC50 (binding) (radioligand binding) PSB-603 Schiedel AC et al (2011)
aa2br_human 154 ECL2 C => S 1.181↑ EC50 (cAMP accumulation) BAY60-6583 Schiedel AC et al (2011)
aa2br_human 166 ECL2 C => S 1.942↓ EC50 (cAMP accumulation) NECA Schiedel AC et al (2011)
aa2br_human 166 ECL2 C => S 1.246↑ IC50 (binding) (radioligand binding) NECA Schiedel AC et al (2011)
aa2br_human 166 ECL2 C => S 1.695↑ IC50 (binding) (radioligand binding) PSB-603 Schiedel AC et al (2011)
aa2br_human 166 ECL2 C => S 1.582↑ EC50 (cAMP accumulation) BAY60-6583 Schiedel AC et al (2011)
aa2br_human 167 ECL2 C => S 1.764↓ EC50 (cAMP accumulation) NECA Schiedel AC et al (2011)
aa2br_human 167 ECL2 C => S 1.807↑ IC50 (binding) (radioligand binding) NECA Schiedel AC et al (2011)
aa2br_human 167 ECL2 C => S 1.494↑ IC50 (binding) (radioligand binding) PSB-603 Schiedel AC et al (2011)
aa2br_human 167 ECL2 C => S 1.612↑ EC50 (cAMP accumulation) BAY60-6583 Schiedel AC et al (2011)
aa2br_human 45.50x50 171 ECL2 C => S N/A EC50 (cAMP accumulation) NECA Schiedel AC et al (2011)
aa2br_human 45.50x50 171 ECL2 C => S Abolished IC50 (binding) (radioligand binding) NECA Schiedel AC et al (2011)
aa2br_human 45.50x50 171 ECL2 C => S Abolished IC50 (binding) (radioligand binding) PSB-603 Schiedel AC et al (2011)
aa2br_human 45.50x50 171 ECL2 C => S N/A EC50 (cAMP accumulation) BAY60-6583 Schiedel AC et al (2011)
aa2br_human 1.35x35 10 TM1 Y => A 5.102↓ EC50 (cAMP accumulation) NECA Thimm D et al (2013)
aa2br_human 1.35x35 10 TM1 Y => A 1.965↓ K(i) (radioligand binding) NECA Thimm D et al (2013)
aa2br_human 1.35x35 10 TM1 Y => A 1.595↓ K(i) (radioligand binding) PSB-603 Thimm D et al (2013)
aa2br_human 1.35x35 10 TM1 Y => A 14.493↓ EC50 (cAMP accumulation) BAY60-6583 Thimm D et al (2013)
aa2br_human 3.28x28 81 TM3 L => A 10.87↓ EC50 (cAMP accumulation) NECA Thimm D et al (2013)
aa2br_human 3.28x28 81 TM3 L => A Abolished K(i) (radioligand binding) NECA Thimm D et al (2013)
aa2br_human 3.28x28 81 TM3 L => A Abolished K(i) (radioligand binding) PSB-603 Thimm D et al (2013)
aa2br_human 3.28x28 81 TM3 L => A 4.95↓ EC50 (cAMP accumulation) BAY60-6583 Thimm D et al (2013)
aa2br_human 5.42x43 186 TM5 N => A 1.937↑ EC50 (cAMP accumulation) NECA Thimm D et al (2013)
aa2br_human 5.42x43 186 TM5 N => A Abolished K(i) (radioligand binding) NECA Thimm D et al (2013)
aa2br_human 5.42x43 186 TM5 N => A Abolished K(i) (radioligand binding) PSB-603 Thimm D et al (2013)
aa2br_human 5.42x43 186 TM5 N => A 15.047↑ EC50 (cAMP accumulation) BAY60-6583 Thimm D et al (2013)
aa2br_human 5.54x54 198 TM5 M => A 1.976↓ EC50 (cAMP accumulation) NECA Thimm D et al (2013)
aa2br_human 5.54x54 198 TM5 M => A 1.058↑ K(i) (radioligand binding) NECA Thimm D et al (2013)
aa2br_human 5.54x54 198 TM5 M => A 1.242↑ K(i) (radioligand binding) PSB-603 Thimm D et al (2013)
aa2br_human 5.54x54 198 TM5 M => A 1.595↓ EC50 (cAMP accumulation) BAY60-6583 Thimm D et al (2013)
aa2br_human 6.48x48 247 TM6 W => A 125.0↓ EC50 (cAMP accumulation) NECA Thimm D et al (2013)
aa2br_human 6.48x48 247 TM6 W => A 13.333↓ K(i) (radioligand binding) NECA Thimm D et al (2013)
aa2br_human 6.48x48 247 TM6 W => A 3.571↓ K(i) (radioligand binding) PSB-603 Thimm D et al (2013)
aa2br_human 6.48x48 247 TM6 W => A 3.003↓ EC50 (cAMP accumulation) BAY60-6583 Thimm D et al (2013)
aa2br_human 6.51x51 250 TM6 V => A 166.667↓ EC50 (cAMP accumulation) NECA Thimm D et al (2013)
aa2br_human 6.51x51 250 TM6 V => A Abolished K(i) (radioligand binding) NECA Thimm D et al (2013)
aa2br_human 6.51x51 250 TM6 V => A Abolished K(i) (radioligand binding) PSB-603 Thimm D et al (2013)
aa2br_human 6.51x51 250 TM6 V => A 2.045↓ EC50 (cAMP accumulation) BAY60-6583 Thimm D et al (2013)
aa2br_human 7.42x41 279 TM7 S => A N/A EC50 (cAMP accumulation) adenosine Thimm D et al (2013)
aa2br_human 7.42x41 279 TM7 S => A >1000.0↓ EC50 (cAMP accumulation) NECA Thimm D et al (2013)
aa2br_human 7.42x41 279 TM7 S => A Abolished K(i) (radioligand binding) NECA Thimm D et al (2013)
aa2br_human 7.42x41 279 TM7 S => A 1.77↓ K(i) (radioligand binding) PSB-603 Thimm D et al (2013)
aa2br_human 7.42x41 279 TM7 S => A 6.628↑ EC50 (cAMP accumulation) BAY60-6583 Thimm D et al (2013)
aa2br_human 7.42x41 279 TM7 S => A 1.257↑ K(i) (radioligand binding) BAY60-6583 Thimm D et al (2013)
aa2br_human 7.45x45 282 TM7 N => D 500.0↓ EC50 (cAMP accumulation) NECA Thimm D et al (2013)
aa2br_human 7.45x45 282 TM7 N => D >15.873↓ K(i) (radioligand binding) NECA Thimm D et al (2013)
aa2br_human 7.45x45 282 TM7 N => D 1.775↑ K(i) (radioligand binding) PSB-603 Thimm D et al (2013)
aa2br_human 7.45x45 282 TM7 N => D 24.39↓ EC50 (cAMP accumulation) BAY60-6583 Thimm D et al (2013)
aa2br_human 7.45x45 282 TM7 N => D 2.475↓ K(i) (radioligand binding) BAY60-6583 Thimm D et al (2013)
aa2br_human 148 ECL2 D => A 1.456↑ EC50 (cAMP accumulation) NECA Seibt BF et al (2013)
aa2br_human 148 ECL2 D => A 1.088↑ K(i) (radioligand binding) NECA Seibt BF et al (2013)
aa2br_human 148 ECL2 D => A Abolished K(i) (radioligand binding) CGS21680 Seibt BF et al (2013)
aa2br_human 148 ECL2 D => A 1.16↑ K(i) (radioligand binding) PSB-603 Seibt BF et al (2013)
aa2br_human 148 ECL2 D => A 2.279↑ EC50 (cAMP accumulation) BAY60-6583 Seibt BF et al (2013)
aa2br_human 148 ECL2 D => A 2.976↓ K(i) (radioligand binding) BAY60-6583 Seibt BF et al (2013)
aa2br_human 149 ECL2 S => A 1.257↑ EC50 (cAMP accumulation) NECA Seibt BF et al (2013)
aa2br_human 149 ECL2 S => A 3.344↓ K(i) (radioligand binding) NECA Seibt BF et al (2013)
aa2br_human 149 ECL2 S => A Abolished K(i) (radioligand binding) CGS21680 Seibt BF et al (2013)
aa2br_human 149 ECL2 S => A 1.189↓ K(i) (radioligand binding) PSB-603 Seibt BF et al (2013)
aa2br_human 149 ECL2 S => A 1.31↑ EC50 (cAMP accumulation) BAY60-6583 Seibt BF et al (2013)
aa2br_human 149 ECL2 S => A 2.506↓ K(i) (radioligand binding) BAY60-6583 Seibt BF et al (2013)
aa2br_human 151 ECL2 T => A 1.248↓ EC50 (cAMP accumulation) NECA Seibt BF et al (2013)
aa2br_human 151 ECL2 T => A 1.919↓ K(i) (radioligand binding) NECA Seibt BF et al (2013)
aa2br_human 151 ECL2 T => A Abolished K(i) (radioligand binding) CGS21680 Seibt BF et al (2013)
aa2br_human 151 ECL2 T => A 1.166↓ K(i) (radioligand binding) PSB-603 Seibt BF et al (2013)
aa2br_human 151 ECL2 T => A 1.364↑ EC50 (cAMP accumulation) BAY60-6583 Seibt BF et al (2013)
aa2br_human 151 ECL2 T => A 2.252↓ K(i) (radioligand binding) BAY60-6583 Seibt BF et al (2013)
aa2br_human 164 ECL2 E => A 3.68↑ EC50 (cAMP accumulation) NECA Seibt BF et al (2013)
aa2br_human 164 ECL2 E => A 1.145↓ K(i) (radioligand binding) NECA Seibt BF et al (2013)
aa2br_human 164 ECL2 E => A Abolished K(i) (radioligand binding) CGS21680 Seibt BF et al (2013)
aa2br_human 164 ECL2 E => A 1.148↓ K(i) (radioligand binding) PSB-603 Seibt BF et al (2013)
aa2br_human 164 ECL2 E => A 2.171↑ EC50 (cAMP accumulation) BAY60-6583 Seibt BF et al (2013)
aa2br_human 164 ECL2 E => A 2.07↓ K(i) (radioligand binding) BAY60-6583 Seibt BF et al (2013)
aa2br_human 165 ECL2 S => A 1.374↓ EC50 (cAMP accumulation) NECA Seibt BF et al (2013)
aa2br_human 165 ECL2 S => A 1.54↑ K(i) (radioligand binding) NECA Seibt BF et al (2013)
aa2br_human 165 ECL2 S => A Abolished K(i) (radioligand binding) CGS21680 Seibt BF et al (2013)
aa2br_human 165 ECL2 S => A 1.462↑ K(i) (radioligand binding) PSB-603 Seibt BF et al (2013)
aa2br_human 165 ECL2 S => A 1.127↓ EC50 (cAMP accumulation) BAY60-6583 Seibt BF et al (2013)
aa2br_human 165 ECL2 S => A 2.41↓ K(i) (radioligand binding) BAY60-6583 Seibt BF et al (2013)
aa2br_human 169 ECL2 V => A 2.553↑ EC50 (cAMP accumulation) NECA Seibt BF et al (2013)
aa2br_human 169 ECL2 V => A 1.042↑ K(i) (radioligand binding) NECA Seibt BF et al (2013)
aa2br_human 169 ECL2 V => A Abolished K(i) (radioligand binding) CGS21680 Seibt BF et al (2013)
aa2br_human 169 ECL2 V => A 2.387↓ K(i) (radioligand binding) PSB-603 Seibt BF et al (2013)
aa2br_human 169 ECL2 V => A 3.659↑ EC50 (cAMP accumulation) BAY60-6583 Seibt BF et al (2013)
aa2br_human 169 ECL2 V => A Abolished K(i) (radioligand binding) BAY60-6583 Seibt BF et al (2013)
aa2br_human 1.36x36 11 TM1 V => I N/A N/A Beukers MW et al (2000)
aa2br_human 1.37x37 12 TM1 A => T N/A N/A Beukers MW et al (2000)
aa2br_human 2.55x55 58 TM2 L => V N/A N/A Beukers MW et al (2000)
aa2br_human 2.56x551 59 TM2 F => L N/A N/A Beukers MW et al (2000)
aa2br_human 7.36x35 273 TM7 N => Y N/A N/A Beukers MW et al (2000)
aa2br_human 1.36x36 11 TM1 V => I N/A N/A Beukers MW et al (2000)
aa2br_human 1.37x37 12 TM1 A => T N/A N/A Beukers MW et al (2000)
aa2br_human 2.55x55 58 TM2 L => V N/A N/A Beukers MW et al (2000)
aa2br_human 2.56x551 59 TM2 F => L N/A N/A Beukers MW et al (2000)
aa2br_human 7.36x35 273 TM7 N => Y N/A N/A Beukers MW et al (2000)
aa2br_human 3.38x38 91 TM3 S => G N/A N/A Beukers MW et al (2004)
aa2br_human 3.38x38 91 TM3 S => G N/A N/A Beukers MW et al (2004)
aa2br_human 3.31x31 84 TM3 F => S N/A N/A Beukers MW et al (2004)
aa2br_human 3.31x31 84 TM3 F => L N/A N/A Beukers MW et al (2004)
aa2br_human 3.31x31 84 TM3 F => L N/A N/A Beukers MW et al (2004)
aa2br_human 2.51x51 54 TM2 V => L N/A N/A Beukers MW et al (2004)
aa2br_human 2.51x51 54 TM2 V => L N/A N/A Beukers MW et al (2004)
aa2br_human 2.39x39 42 TM2 T => A N/A N/A Beukers MW et al (2004)
aa2br_human 12.48x48 36 ICL1 N => D N/A N/A Beukers MW et al (2004)
aa2br_human 2.39x39 42 TM2 T => A N/A N/A Li Q et al (2007)
aa2br_human 2.51x51 54 TM2 V => A N/A N/A Li Q et al (2007)
aa2br_human 1.43x43 18 TM1 A => T N/A N/A Li Q et al (2007)
aa2br_human 34.52x52 112 ICL2 R => S N/A N/A Li Q et al (2007)
aa2br_human 6.51x51 250 TM6 V => M N/A N/A Li Q et al (2007)
aa2br_human 5.70x70 214 TM5 Q => L N/A N/A Li Q et al (2007)
aa2br_human 3.30x30 83 TM3 C => Y N/A N/A Li Q et al (2007)
aa2br_human 3.31x31 84 TM3 F => L N/A N/A Li Q et al (2007)
aa2br_human 3.53x53 106 TM3 A => V N/A N/A Li Q et al (2007)
aa2br_human 6.31x31 230 TM6 I => N N/A N/A Li Q et al (2007)
aa2br_human 6.58x58 257 TM6 T => S N/A N/A Li Q et al (2007)
aa2br_human 6.55x55 254 TM6 N => Y N/A N/A Li Q et al (2007)
aa2br_human 3.42x42 95 TM3 S => G N/A N/A Li Q et al (2007)
aa2br_human 2.63x62 66 TM2 T => A N/A N/A Li Q et al (2007)
aa2br_human 1.48x48 23 TM1 A => V N/A N/A Li Q et al (2007)
aa2br_human 12.48x48 36 ICL1 N => S N/A N/A Li Q et al (2007)
aa2br_human 3.31x31 84 TM3 F => S N/A N/A Li Q et al (2007)
aa2br_human 6.41x41 240 TM6 V => M N/A N/A Li Q et al (2007)
aa2br_human 1.36x36 11 TM1 V => I No effect K(i) (Binding - Radioligand competition/displacement) NECA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 1.36x36 11 TM1 V => I No effect K(i) (Binding - Radioligand competition/displacement) R-PIA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 1.36x36 11 TM1 V => I No effect K(i) (Binding - Radioligand competition/displacement) 2-ClAdo Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 1.36x36 11 TM1 V => I No effect EC50 (Functional - cAMP accumulation) NECA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 1.36x36 11 TM1 V => I No effect EC50 (Functional - cAMP accumulation) R-PIA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 1.36x36 11 TM1 V => I No effect EC50 (Functional - cAMP accumulation) 2-ClAdo Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 1.37x37 12 TM1 A => T 2.41↓ K(i) (Binding - Radioligand competition/displacement) NECA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 1.37x37 12 TM1 A => T 1.715↓ K(i) (Binding - Radioligand competition/displacement) R-PIA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 1.37x37 12 TM1 A => T 2.358↓ K(i) (Binding - Radioligand competition/displacement) 2-ClAdo Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 12.48x48 36 ICL1 N => D 2.31↑ EC50 (Functional - Other) NECA Beukers MW et al (2004) Jespers W et al (2018)
aa2br_human 2.39x39 42 TM2 T => A 4.85↑ EC50 (Functional - Other) NECA Beukers MW et al (2004) Jespers W et al (2018)
aa2br_human 2.39x39 42 TM2 T => A 8.667↑ EC50 (Functional - cAMP accumulation) NECA Beukers MW et al (2004) Jespers W et al (2018)
aa2br_human 2.51x51 54 TM2 V => L 6.258↑ EC50 (Functional - Other) NECA Beukers MW et al (2004) Jespers W et al (2018)
aa2br_human 2.55x55 58 TM2 L => V No effect K(i) (Binding - Radioligand competition/displacement) NECA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 2.55x55 58 TM2 L => V No effect K(i) (Binding - Radioligand competition/displacement) R-PIA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 2.55x55 58 TM2 L => V No effect K(i) (Binding - Radioligand competition/displacement) 2-ClAdo Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 2.55x55 58 TM2 L => V No effect EC50 (Functional - cAMP accumulation) NECA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 2.55x55 58 TM2 L => V No effect EC50 (Functional - cAMP accumulation) R-PIA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 2.55x55 58 TM2 L => V No effect EC50 (Functional - cAMP accumulation) 2-ClAdo Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 2.56x551 59 TM2 F => L Abolished effect K(i) (Binding - Radioligand competition/displacement) NECA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 2.56x551 59 TM2 F => L Abolished effect EC50 (Functional - cAMP accumulation) NECA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => L 1.403↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => I 1.149↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => E 1.255↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => K 1.319↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => M 1.383↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => Y 1.565↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => V 1.776↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => H 4.651↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => D 4.695↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => C 6.25↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => S 9.901↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => R Abolished effect EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => A Abolished effect EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => G Abolished effect EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => L 1.246↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => I 1.629↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => E 1.656↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => K 1.359↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => M 1.406↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => Y 1.247↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => V 2.11↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => H 2.793↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => D 4.785↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => C 3.846↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => S 3.937↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => R Abolished effect EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => A Abolished effect EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 23.50x50 71 ECL1 F => G Abolished effect EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => G 2.0↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => Q 3.133↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => E 1.918↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => N 1.541↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => S 1.382↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => K 1.119↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => Y 1.119↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => A 1.033↑ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => R 1.032↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => T 1.149↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => W 2.096↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => C 2.725↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => L 3.436↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => V 3.546↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => F 6.25↓ EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => I Abolished effect EC50 (Functional - Other) NECA Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => G 1.884↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => Q 2.314↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => E 1.227↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => N 1.8↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => S 1.688↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => K 1.049↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => Y 1.157↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => A 1.779↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => R 1.025↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => T 1.667↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => W 1.876↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => C 1.927↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => L 2.32↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => V 2.985↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => F 1.965↓ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.21x21 74 TM3 D => I Abolished effect EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2011) Jespers W et al (2018)
aa2br_human 3.31x31 84 TM3 F => L 2.694↑ EC50 (Functional - Other) NECA Beukers MW et al (2004) Jespers W et al (2018)
aa2br_human 3.31x31 84 TM3 F => S 6.467↑ EC50 (Functional - Other) NECA Beukers MW et al (2004) Jespers W et al (2018)
aa2br_human 3.38x38 91 TM3 S => G 1.59↑ EC50 (Functional - Other) NECA Beukers MW et al (2004) Jespers W et al (2018)
aa2br_human 3.50x50 103 TM3 R => A Abolished effect EC50 (Functional - Other) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 3.50x50 103 TM3 R => A Decreased effect IC50 (Binding - Radioligand competition/displacement) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 3.54x54 107 TM3 I => A No response EC50 (Functional - Other) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 3.54x54 107 TM3 I => A Decreased effect IC50 (Binding - Radioligand competition/displacement) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 4.56x56 136 TM4 I => T 13.7↑ EC50 (Functional - Other) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 4.61x61 141 TM4 F => L 25.37↑ EC50 (Functional - Other) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 4.61x61 141 TM4 F => L 5.333↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 4.61x61 141 TM4 F => L 12.797↑ IC50 (Binding - Radioligand competition/displacement) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 4.61x61 141 TM4 F => L 5.73↑ IC50 (Binding - Radioligand competition/displacement) BAY 60-6583 Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 4.61x61 141 TM4 F => L 1.499↓ IC50 (Binding - Radioligand competition/displacement) ZM241385 Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 166 ECL2 C => L 11.417↑ EC50 (Functional - Other) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 167 ECL2 C => S 15.568↑ EC50 (Functional - Other) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 167 ECL2 C => S 2.087↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 167 ECL2 C => S 9.098↑ IC50 (Binding - Radioligand competition/displacement) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 167 ECL2 C => S No effect IC50 (Binding - Radioligand competition/displacement) BAY 60-6583 Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 167 ECL2 C => S No effect IC50 (Binding - Radioligand competition/displacement) ZM241385 Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 168 ECL2 L => P 12.455↑ EC50 (Functional - Other) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 45.52x52 173 ECL2 F => L 13.7↑ EC50 (Functional - Other) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 5.56x56 200 TM5 V => G 10.538↑ EC50 (Functional - Other) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 5.58x58 202 TM5 Y => S 10.538↑ EC50 (Functional - Other) NECA Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 5.58x58 202 TM5 Y => S 9.796↑ EC50 (Functional - Other) BAY 60-6583 Peeters MC et al (2012) Jespers W et al (2018)
aa2br_human 5.69x69 213 TM5 L => A 1.667↓ EC50 (Functional - Other) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 5.69x69 213 TM5 L => A 1.027↓ IC50 (Binding - Radioligand competition/displacement) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 6.36x36 235 TM6 S => A 1.0 EC50 (Functional - Other) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 6.36x36 235 TM6 S => A Decreased effect IC50 (Binding - Radioligand competition/displacement) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 6.37x37 236 TM6 L => A 7.9↑ EC50 (Functional - Other) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 6.37x37 236 TM6 L => A 1.016↓ IC50 (Binding - Radioligand competition/displacement) NECA Liu R et al (2014) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 1.727↓ K(i) (Binding - Radioligand competition/displacement) NECA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 1.615↑ K(i) (Binding - Radioligand competition/displacement) R-PIA Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 2.924↓ K(i) (Binding - Radioligand competition/displacement) 2-ClAdo Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 61.111↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL319387 Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 21.2↑ K(i) (Binding - Radioligand competition/displacement) 181873-18-7 Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 3.514↑ K(i) (Binding - Radioligand competition/displacement) 144348-17-4 Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 6.104↑ K(i) (Binding - Radioligand competition/displacement) L005974 Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 3.158↑ K(i) (Binding - Radioligand competition/displacement) CGS21680 Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 3.448↑ K(i) (Binding - Radioligand competition/displacement) Cid13830107(R) Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 8.947↑ K(i) (Binding - Radioligand competition/displacement) Cid13830107(R) Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 2.463↓ K(i) (Binding - Radioligand competition/displacement) ZM-241385 Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 1.147↓ K(i) (Binding - Radioligand competition/displacement) SCH 58261 Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 2.667↑ K(i) (Binding - Radioligand competition/displacement) xanthine amine congener Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.36x35 273 TM7 N => Y 10.0↑ EC50 (Functional - cAMP accumulation) 181873-18-7 Beukers MW et al (2000) Jespers W et al (2018)
aa2br_human 7.56x56 293 TM7 R => A No effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.47x47 294 H8 N => A No effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.48x48 295 H8 R => A No effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.49x49 296 H8 D => A No effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.50x50 297 H8 F => A Abolished effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.51x51 298 H8 R => A Abolished effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.52x52 299 H8 Y => A No effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.53x53 300 H8 T => A No effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.54x54 301 H8 F => A No effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.55x55 302 H8 H => A No effect EC50 (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.50x50 297 H8 F => A N/A N/A NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.51x51 298 H8 R => A N/A N/A NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 7.56x56 293 TM7 R => A 100000000.0↑ pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.47x47 294 H8 N => A 1000000.0↑ pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.48x48 295 H8 R => A 100000.0↑ pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.49x49 296 H8 D => A 1000000000.0↑ pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.50x50 297 H8 F => A N/A pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.51x51 298 H8 R => A N/A pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.52x52 299 H8 Y => A 1.0 pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.53x53 300 H8 T => A 100.0↑ pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.54x54 301 H8 F => A 1000.0↑ pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
aa2br_human 8.55x55 302 H8 H => A 10.0↓ pmol/mg (Functional - cAMP accumulation) NECA Sun Y et al (2016) Jespers W et al (2018)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 N T L Q ICL1ECL1 F C T ECL1ICL2 P L R Y K S L V ICL2ECL2 W N S K D S A T N N C T E P W D G T T N E S C C L V K C L F E N V V ECL2ICL3 L M D ICL3ECL3 P A Q G K N K ECL3N-term M L L N-termC-term S G N G Q A G V Q P A L G V G L C-term E T Q D A L Y V A L E L V I A A L S V A G N V L V C A A V G T A T P T N Y F L V S L A A A D V A V G L F A I P F A I T I S L G D F Y G C L F L A C F V L V L T Q S S I F S L L A V A V D R Y L A I C V T G T R A R G V I A V L W V L A F G I G L T P F L G P M S Y M V Y F N F F G C V L P P L L I M L V I Y I K I F L V A C R Q L Q R T E H S R T T L Q R E I H A A K S L A M I V G I F A L C W L P V H A V N C V T L F Q P K W A M N M A I L L S H A N S V V N P I V Y A Y R N R D F H K Y L L V K F R Y T I I S R C Q A D
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G A V S L A A I V L E L A V Y L A D 1 V S L A A A D V A V G F L A I P F A I T I 2 A L L S F I S S Q T L V L V F C A L F L 3 A R G V I A V L W V L A F G I G L T P F 4 Y I V L M I L L P P L V C G F F N F Y V M Y 5 A M I V G I F A L C W L P V H A V N C V 6 I P N V V S N A H S L L I A M N M A W 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
A2B receptor
TM1
1x35 1.35x35 Y10
1x36 1.36x36 V11
1x37 1.37x37 A12
1x43 1.43x43 A18
1x48 1.48x48 A23
1x54 1.54x54 C29
TM2
2x39 2.39x39 T42
2x51 2.51x51 V54
2x55 2.55x55 L58
2x551 2.56x551 F59
2x62 2.63x62 T66
TM3
3x21 3.21x21 D74
3x25 3.25x25 C78
3x28 3.28x28 L81
3x30 3.30x30 C83
3x31 3.31x31 F84
3x38 3.38x38 S91
3x42 3.42x42 S95
3x50 3.50x50 R103
3x53 3.53x53 A106
3x54 3.54x54 I107
TM4
4x50 4.50x50 W130
4x56 4.56x56 I136
4x61 4.61x61 F141
TM5
5x43 5.42x43 N186
5x54 5.54x54 M198
5x56 5.56x56 V200
5x58 5.58x58 Y202
5x69 5.69x69 L213
5x70 5.70x70 Q214
5x71 5.71x71 R215
TM6
6x31 6.31x31 I230
6x36 6.36x36 S235
6x37 6.37x37 L236
6x41 6.41x41 V240
6x48 6.48x48 W247
6x50 6.50x50 P249
6x51 6.51x51 V250
6x55 6.55x55 N254
6x58 6.58x58 T257
6x60 6.60x60 F259
TM7
7x35 7.36x35 N273
7x41 7.42x41 S279
7x42 7.43x42 H280
7x45 7.45x45 N282
7x56 7.56x56 R293
H8
8x47 8.47x47 N294
8x48 8.48x48 R295
8x49 8.49x49 D296
8x50 8.50x50 F297
8x51 8.51x51 R298
8x52 8.52x52 Y299
8x53 8.53x53 T300
8x54 8.54x54 F301
8x55 8.55x55 H302
8x63 8.63x63 L310
8x68 8.68x68 V315