Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
ada1d_human 2.64x63 156 TM2 M => F N/A N/A Hamaguchi N et al (1996)
ada1d_human 2.64x63 156 TM2 M => F 831.764↑ pK(i) (Binding - Radioligand competition/displacement) compound1 Hamaguchi N et al (1996) Vass M et al (2019)
ada1d_human 2.64x63 156 TM2 M => F 79.433↑ pK(i) (Binding - Radioligand competition/displacement) compound2 Hamaguchi N et al (1996) Vass M et al (2019)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R H L Q ICL1ECL1 F W A F ECL1ICL2 S L K Y P A I M ICL2ECL2 K E P V P P D E R F C G I T E ECL2ICL3 G V K R E R G K A S E V V L R I H C R G A A T G A D G A H G M R S A K G H T F R S S L S V R ICL3ECL3 P Q L K P ECL3N-term M T F R D L L S V S F E G P R P D S S A G G S S A G G G G G S A G G A A P S E G P A V G G V P G G A G G G G G V V G A G S G E D N R S S A G E P G S A G A G G D V N G T A A V G G N-termC-term C Q C R R R R R R R P L W R V Y G H H W R A S T S G L R Q D C A P S S G D A P P G A P L A L T A L P D P D P E P P G T P E M Q A P V A S R R K P P S A F R E W R L L G P F R R P T T Q L R A K V S S L S H K I R A G G A Q R A E A A C A Q R S E V E A V S L G V P H E V A E G A T C Q A Y E L A D Y S N L R E T D I C-term L V V S A Q G V G V G V F L A A F I L M A V A G N L L V I L S V A C N T V T N Y F I V N L A V A D L L L S A T V L P F S A T M E V L G G R A F C D V W A A V D V L C C T A S I L S L C T I S V D R Y V G V R H T E R K A A A I L A L L W V V A L V V S V G P L L G W E A G Y A V F S S V C S F Y L P M A V I V V M Y C R V Y V V A R S T T R S L E A L L K F S R E K K A A K T L A I V V G V F V L C W F P F F F V L P L G S L F S E G V F K V I F W L G Y F N S C V N P L I Y P C S S R E F L R F K R A L L R !
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N G A V A M L I F A A L F V G V G V G 1 V N L A V A D L L L S T A V L P F S A T M 2 T C L S L I S A T C C L V D V A A W V D 3 A A A I L A L L W V V A L V V S V G P L 4 Y M V V I V A M P L Y F S C V S S F V A Y 5 A I V V G V F V L C W F P F F F V L P L 6 L P N V C S N F Y G L W F I V K F V G 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
α1D-adrenoceptor
TM2
2x63 2.64x63 M156