Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
cnr1_human 3.28x28 192 TM3 K => A N/A N/A Song ZH et al (1996)
cnr1_human 257 ECL2 C => S N/A N/A Shire D et al (1996)
cnr1_human 264 ECL2 C => S N/A N/A Shire D et al (1996)
cnr1_human 257 ECL2 C => A N/A N/A Shire D et al (1996)
cnr1_human 264 ECL2 C => A N/A N/A Shire D et al (1996)
cnr1_human 2.50x50 163 TM2 D => E N/A N/A Tao Q et al (1998)
cnr1_human 2.50x50 163 TM2 D => N N/A N/A Tao Q et al (1998)
cnr1_human 3.28x28 192 TM3 K => R N/A N/A Chin CN et al (1998)
cnr1_human 3.28x28 192 TM3 K => Q N/A N/A Chin CN et al (1998)
cnr1_human 3.28x28 192 TM3 K => E N/A N/A Chin CN et al (1998)
cnr1_human 3.31x31 195 TM3 G => S N/A N/A Chin CN et al (1999)
cnr1_human 3.34x34 198 TM3 A => M N/A N/A Chin CN et al (1999)
cnr1_human 3.28x28 192 TM3 K => A N/A N/A Pan X et al (1998)
cnr1_human 5.46x46 282 TM5 V => F N/A N/A Song ZH et al (1999)
cnr1_human 2.50x50 163 TM2 D => N N/A N/A McAllister SD et al (1999)
cnr1_human 98 N-term C => A N/A N/A Fay JF et al (2005)
cnr1_human 107 N-term C => A N/A N/A Fay JF et al (2005)
cnr1_human 1.30x30 114 TM1 S => A N/A N/A Murphy JW et al (2003)
cnr1_human 1.31x31 115 TM1 Q => A N/A N/A Murphy JW et al (2003)
cnr1_human 2.50x50 163 TM2 D => E N/A N/A Tao Q et al (1998)
cnr1_human 2.50x50 163 TM2 D => N N/A N/A Roche JP et al (1999)
cnr1_human 2.50x50 163 TM2 D => N N/A N/A McAllister SD et al (1999)
cnr1_human 2.50x50 163 TM2 D => N N/A N/A Tao Q et al (1998)
cnr1_human 181 ECL1 H => A N/A N/A Murphy JW et al (2003)
cnr1_human 182 ECL1 R => A N/A N/A Murphy JW et al (2003)
cnr1_human 183 ECL1 K => A N/A N/A Murphy JW et al (2003)
cnr1_human 184 ECL1 D => A N/A N/A Murphy JW et al (2003)
cnr1_human 3.24x24 188 TM3 V => A N/A N/A Murphy JW et al (2003)
cnr1_human 3.25x25 189 TM3 F => A N/A N/A Murphy JW et al (2003)
cnr1_human 3.27x27 191 TM3 F => L N/A N/A Chin CN et al (1999)
cnr1_human 3.28x28 192 TM3 K => A N/A N/A Tao Q et al (1999)
cnr1_human 3.28x28 192 TM3 K => A N/A N/A McAllister SD et al (2002)
cnr1_human 3.28x28 192 TM3 K => A N/A N/A Hurst DP et al (2002)
cnr1_human 3.28x28 192 TM3 K => A N/A N/A Pan X et al (1998)
cnr1_human 3.28x28 192 TM3 K => E N/A N/A Chin CN et al (1999)
cnr1_human 3.28x28 192 TM3 K => E N/A N/A Chin CN et al (1998)
cnr1_human 3.28x28 192 TM3 K => E N/A N/A Pan X et al (1998)
cnr1_human 3.28x28 192 TM3 K => Q N/A N/A Tao Q et al (1999)
cnr1_human 3.28x28 192 TM3 K => Q N/A N/A Chin CN et al (1998)
cnr1_human 3.28x28 192 TM3 K => R N/A N/A Tao Q et al (1999)
cnr1_human 3.28x28 192 TM3 K => R N/A N/A Chin CN et al (1998)
cnr1_human 3.29x29 193 TM3 L => I N/A N/A Chin CN et al (1999)
cnr1_human 3.31x31 195 TM3 G => S N/A N/A Chin CN et al (1999)
cnr1_human 3.34x34 198 TM3 A => M N/A N/A Chin CN et al (1999)
cnr1_human 3.35x35 199 TM3 S => T N/A N/A Chin CN et al (1999)
cnr1_human 257 ECL2 C => A N/A N/A Shire D et al (1996)
cnr1_human 257 ECL2 C => A N/A N/A Fay JF et al (2005)
cnr1_human 257 ECL2 C => S N/A N/A Shire D et al (1996)
cnr1_human 264 ECL2 C => A N/A N/A Shire D et al (1996)
cnr1_human 264 ECL2 C => A N/A N/A Fay JF et al (2005)
cnr1_human 264 ECL2 C => S N/A N/A Shire D et al (1996)
cnr1_human 5.39x39 275 TM5 Y => F N/A N/A McAllister SD et al (2002)
cnr1_human 5.39x39 275 TM5 Y => I N/A N/A McAllister SD et al (2002)
cnr1_human 5.46x46 282 TM5 V => F N/A N/A Murphy JW et al (2003)
cnr1_human 6.33x33 341 TM6 L => A N/A N/A Abadji V et al (1999)
cnr1_human 6.34x34 342 TM6 A => L N/A N/A Abadji V et al (1999)
cnr1_human 6.47x47 355 TM6 C => A N/A N/A Fay JF et al (2005)
cnr1_human 7.38x37 382 TM7 C => A N/A N/A Fay JF et al (2005)
cnr1_human 7.42x41 386 TM7 C => A N/A N/A Fay JF et al (2005)
cnr1_human 7.42x41 386 TM7 C => M N/A N/A Fay JF et al (2005)
cnr1_human 5.53x53 289 TM5 F => N N/A N/A Latek D et al (2011)
cnr1_human 6.30x30 338 TM6 D => N N/A N/A Latek D et al (2011)
cnr1_human 7.42x41 386 TM7 C => M N/A N/A Fay JF et al (2005)
cnr1_human 98 N-term C => A N/A N/A Fay JF et al (2005)
cnr1_human 6.47x47 355 TM6 C => A N/A N/A Fay JF et al (2005)
cnr1_human 7.42x41 386 TM7 C => A N/A N/A Fay JF et al (2005)
cnr1_human 7.38x37 382 TM7 C => A N/A N/A Fay JF et al (2005)
cnr1_human 107 N-term C => A N/A N/A Fay JF et al (2005)
cnr1_human 2.61x61 174 TM2 F => A N/A N/A Shim JY et al (2011)
cnr1_human 2.64x64 177 TM2 F => A N/A N/A Shim JY et al (2011)
cnr1_human 3.29x29 193 TM3 L => A N/A N/A Shim JY et al (2011)
cnr1_human 6.55x55 363 TM6 M => A N/A N/A Shim JY et al (2011)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM1
1x30 1.30x30 S114
1x31 1.31x31 Q115
TM2
2x50 2.50x50 D163
2x61 2.61x61 F174
2x64 2.64x64 F177
TM3
3x24 3.24x24 V188
3x25 3.25x25 F189
3x27 3.27x27 F191
3x28 3.28x28 K192
3x29 3.29x29 L193
3x31 3.31x31 G195
3x34 3.34x34 A198
3x35 3.35x35 S199
TM5
5x39 5.39x39 Y275
5x46 5.46x46 V282
5x53 5.53x53 F289
TM6
6x30 6.30x30 D338
6x33 6.33x33 L341
6x34 6.34x34 A342
6x47 6.47x47 C355
6x55 6.55x55 M363
TM7
7x37 7.38x37 C382
7x41 7.42x41 C386