Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
drd3_human 6.34x34 328 TM6 T => S N/A N/A McAllister G et al (1993)
drd3_human 6.34x34 328 TM6 T => S N/A N/A McAllister G et al (1993)
drd3_human 1.39x39 36 TM1 Y => L N/A N/A Lundstrom K et al (1998)
drd3_human 3.24x24 102 TM3 C => H N/A N/A Lundstrom K et al (1998)
drd3_human 6.55x55 349 TM6 H => L N/A N/A Lundstrom K et al (1998)
drd3_human 7.31x30 361 TM7 S => A N/A N/A Lundstrom K et al (1998)
drd3_human 7.31x30 361 TM7 S => P N/A N/A Lundstrom K et al (1998)
drd3_human 7.38x37 368 TM7 T => F N/A N/A Lundstrom K et al (1998)
drd3_human 7.38x37 368 TM7 T => V N/A N/A Lundstrom K et al (1998)
drd3_human 7.39x38 369 TM7 T => V N/A N/A Lundstrom K et al (1998)
drd3_human 172 ECL2 F => A N/A N/A Lundstrom K et al (1998)
drd3_human 3.36x36 114 TM3 C => S N/A N/A Alberts GL et al (1998)
drd3_human 5.42x43 192 TM5 S => A N/A N/A Sartania N et al (1999)
drd3_human 5.43x44 193 TM5 S => A N/A N/A Sartania N et al (1999)
drd3_human 5.46x461 196 TM5 S => A N/A N/A Sartania N et al (1999)
drd3_human 3.36x36 114 TM3 C => S N/A N/A Alberts GL et al (1998)
drd3_human 6.55x55 349 TM6 H => L N/A N/A Lundstrom K et al (1998)
drd3_human 7.39x38 369 TM7 T => V N/A N/A Lundstrom K et al (1998)
drd3_human 3.32x32 110 TM3 D => A N/A N/A Kufareva I et al (2011)
drd3_human 1.39x39 36 TM1 Y => F 5.208↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => F 1.799↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => L 29.412↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => L 22.222↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => L 6.993↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => L 9.259↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => Q 10.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => Q 12.346↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.36x36 114 TM3 C => L 2.778↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.36x36 114 TM3 C => L 1.562↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.51x51 182 ECL2 S => I 3.125↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.51x51 182 ECL2 S => I 1.316↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.52x52 183 ECL2 I => F 2.639↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => A 1.6↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => A 1.441↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => I 4.274↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => I 2.519↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.35x34 365 TM7 Y => L 3.922↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.35x34 365 TM7 Y => L 1.401↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.43x42 373 TM7 Y => F 55.556↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.43x42 373 TM7 Y => F 40.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL1081023 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.36x36 114 TM3 C => S 3.067↓ K(i) (Binding - Radioligand competition/displacement) cabergoline Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 3.215↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL140612 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 1.969↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL140612 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 1.218↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL140612 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 5.714↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL140612 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 66.667↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL142020 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 38.462↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL142020 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 12.5↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL142020 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 3.7↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL142020 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 1.571↑ K(i) (Binding - Radioligand competition/displacement) lisuride Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E >52.632↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL162762 Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 30.303↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL162762 Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 5.0↓ K(i) (Binding - Radioligand competition/displacement) nemonapride Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 38.462↓ K(i) (Binding - Radioligand competition/displacement) quinpirole Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 1.163↓ K(i) (Binding - Radioligand competition/displacement) quinpirole Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 5.43x44 193 TM5 S => A 1.055↓ K(i) (Binding - Radioligand competition/displacement) quinpirole Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 5.46x461 196 TM5 S => A 1.227↑ K(i) (Binding - Radioligand competition/displacement) quinpirole Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 1.018↓ K(d) (Binding - Radioligand competition/displacement) spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 1.0 K(d) (Binding - Radioligand competition/displacement) spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 3.559↓ K(d) (Binding - Radioligand competition/displacement) spiperone Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 3.704↓ K(d) (Binding - Radioligand competition/displacement) spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 1.385↑ K(d) (Binding - Radioligand competition/displacement) spiperone Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 5.43x44 193 TM5 S => A 2.769↑ K(d) (Binding - Radioligand competition/displacement) spiperone Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 5.46x461 196 TM5 S => A 1.636↑ K(d) (Binding - Radioligand competition/displacement) spiperone Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 2.261↑ K(d) (Binding - Radioligand competition/displacement) spiperone Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 1.852↓ K(d) (Binding - Radioligand competition/displacement) spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => F Abolished effect K(d) (Binding - Radioligand competition/displacement) spiperone Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 5.988↓ K(i) (Binding - Radioligand competition/displacement) spiperone Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 1.009↓ K(d) (Binding - Radioligand saturation) spiperone Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.621↑ K(d) (Binding - Radioligand saturation) spiperone Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 18.519↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL269004 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.123↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL269004 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 100.0↓ K(i) (Binding - Radioligand competition/displacement) (+)-AJ76 Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 250.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL278751 Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.585↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.24x24 102 TM3 C => H 3.981↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 333.333↓ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 3.205↓ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 4.975↓ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 5.43x44 193 TM5 S => A 1.099↑ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 5.46x461 196 TM5 S => A 1.747↑ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 76.923↓ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.995↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 1.585↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 1.259↓ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 3.162↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 10.0↑ pK(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 2.35↑ K(i) (Binding - Radioligand competition/displacement) 7-OH-DPAT Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.0 pK(i) (Binding - Radioligand competition/displacement) CHEMBL294747 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.24x24 102 TM3 C => H 1.996↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL294747 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 1.259↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL294747 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL294747 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 3.165↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL294747 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 1.585↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL294747 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 1.585↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL294747 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.0 pK(i) (Binding - Radioligand competition/displacement) CHEMBL294747 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 13.699↓ K(i) (Binding - Radioligand competition/displacement) pramipexole Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 1.109↓ K(i) (Binding - Radioligand competition/displacement) FAUC213 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 5.188↑ K(i) (Binding - Radioligand competition/displacement) FAUC213 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 1.445↓ K(i) (Binding - Radioligand competition/displacement) FAUC213 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 180.435↑ K(i) (Binding - Radioligand competition/displacement) FAUC213 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.585↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL334529 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.24x24 102 TM3 C => H 3.162↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL334529 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 5.0↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL334529 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 3.162↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL334529 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 1.585↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL334529 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 1.259↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL334529 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 3.162↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL334529 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 6.31↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL334529 Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 6.289↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL456825 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.623↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL456825 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 10.989↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL457024 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.113↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL457024 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 500.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL484202 Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 13.158↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL484202 Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 1000.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL484358 Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W 25.641↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL484358 Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 2.667↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL514885 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 1.572↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL514885 Kortagere S et al (2011) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 76.923↓ K(i) (Binding - Radioligand competition/displacement) apomorphine Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.585↓ pK(i) (Binding - Radioligand competition/displacement) haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => F 1.625↑ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => F 1.806↑ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => L 12.048↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => L 3.39↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => L 8.696↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => L 2.597↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => Q 6.711↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => Q 5.618↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.24x24 102 TM3 C => H 1.585↓ pK(i) (Binding - Radioligand competition/displacement) haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 16.393↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => L 19.231↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.36x36 114 TM3 C => L 26.316↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.51x51 182 ECL2 S => I 5.236↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.51x51 182 ECL2 S => I 3.356↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.52x52 183 ECL2 I => F 15.385↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.52x52 183 ECL2 I => F 2.77↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => A 1.247↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => A 1.307↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => I 2.183↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => I 1.508↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 6.55x55 349 TM6 H => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.585↓ pK(i) (Binding - Radioligand competition/displacement) haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 5.0↓ pK(i) (Binding - Radioligand competition/displacement) haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.35x34 365 TM7 Y => L 1.678↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.35x34 365 TM7 Y => L 1.862↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.38x37 368 TM7 T => F 3.165↓ pK(i) (Binding - Radioligand competition/displacement) haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 1.259↓ pK(i) (Binding - Radioligand competition/displacement) haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 2.512↑ pK(i) (Binding - Radioligand competition/displacement) haloperidol Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.43x42 373 TM7 Y => F 4.115↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.43x42 373 TM7 Y => F 3.534↓ K(i) (Binding - Radioligand competition/displacement) haloperidol Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.61x60 86 TM2 V => F 111.111↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL550222 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 66.667↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL550222 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 500.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL550222 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 1.259↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL550222 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 8.621↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL561622 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.61x60 86 TM2 V => F 28.571↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL561763 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 16.667↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL561763 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 25.0↓ K(i) (Binding - Radioligand competition/displacement) CHEMBL561763 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 2.167↑ K(i) (Binding - Radioligand competition/displacement) CHEMBL561763 Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.259↓ pK(i) (Binding - Radioligand competition/displacement) dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.24x24 102 TM3 C => H 1.259↓ pK(i) (Binding - Radioligand competition/displacement) dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 15.385↓ K(i) (Binding - Radioligand competition/displacement) dopamine Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 5.42x43 192 TM5 S => A 62.5↓ K(i) (Binding - Radioligand competition/displacement) dopamine Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 5.43x44 193 TM5 S => A 2.075↓ K(i) (Binding - Radioligand competition/displacement) dopamine Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 5.46x461 196 TM5 S => A 1.172↑ K(i) (Binding - Radioligand competition/displacement) dopamine Sartania N et al (1999) Kooistra AJ et al (2013)
drd3_human 6.51x51 345 TM6 F => W >1000.0↓ K(i) (Binding - Radioligand competition/displacement) dopamine Dorfler M et al (2008) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 15.873↓ pK(i) (Binding - Radioligand competition/displacement) dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 3.984↓ pK(i) (Binding - Radioligand competition/displacement) dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 1.0 pK(i) (Binding - Radioligand competition/displacement) dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 1.996↓ pK(i) (Binding - Radioligand competition/displacement) dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 5.012↑ pK(i) (Binding - Radioligand competition/displacement) dopamine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.24x24 102 TM3 C => H 3.981↑ pK(i) (Binding - Radioligand competition/displacement) chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 34.483↓ K(i) (Binding - Radioligand competition/displacement) chlorpromazine Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 1.995↑ pK(i) (Binding - Radioligand competition/displacement) chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.585↑ pK(i) (Binding - Radioligand competition/displacement) chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 1.0 pK(i) (Binding - Radioligand competition/displacement) chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 1.585↑ pK(i) (Binding - Radioligand competition/displacement) chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 2.512↑ pK(i) (Binding - Radioligand competition/displacement) chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 3.162↑ pK(i) (Binding - Radioligand competition/displacement) chlorpromazine Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 55.556↓ K(i) (Binding - Radioligand competition/displacement) PRECLAMOL Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 7.692↓ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => L 1.259↓ pK(i) (Binding - Radioligand competition/displacement) raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.24x24 102 TM3 C => H 1.585↑ pK(i) (Binding - Radioligand competition/displacement) raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 3.36x36 114 TM3 C => S 28.571↓ K(i) (Binding - Radioligand competition/displacement) raclopride Alberts GL et al (1998) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => L 10.0↓ pK(i) (Binding - Radioligand competition/displacement) raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => A 1.259↑ pK(i) (Binding - Radioligand competition/displacement) raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.31x30 361 TM7 S => P 1.585↓ pK(i) (Binding - Radioligand competition/displacement) raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => F 1.0 pK(i) (Binding - Radioligand competition/displacement) raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.38x37 368 TM7 T => V 1.259↑ pK(i) (Binding - Radioligand competition/displacement) raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 7.39x38 369 TM7 T => V 3.162↑ pK(i) (Binding - Radioligand competition/displacement) raclopride Lundstrom K et al (1998) Kooistra AJ et al (2013)
drd3_human 1.39x39 36 TM1 Y => F 1.667↑ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => F 2.5↑ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => L 2.5↑ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => L 1.25↑ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => L 1.2↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => L 2.5↑ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => Q 1.2↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => Q 1.0 K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.36x36 114 TM3 C => L 1.799↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.36x36 114 TM3 C => L 1.667↑ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.51x51 182 ECL2 S => I 1.0 K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.51x51 182 ECL2 S => I 2.5↑ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.52x52 183 ECL2 I => F 1.799↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.52x52 183 ECL2 I => F 1.2↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => A 1.0 K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => A 1.401↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => I 1.6↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => I 2.398↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.35x34 365 TM7 Y => L 1.401↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.35x34 365 TM7 Y => L 2.0↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.43x42 373 TM7 Y => F 1.401↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.43x42 373 TM7 Y => F 2.801↓ K(i) (Binding - Radioligand competition/displacement) eticlopride Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => F 1.062↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => F 1.36↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => L 6.452↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 1.39x39 36 TM1 Y => L 3.817↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => L 1.441↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => L 1.088↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => Q 1.764↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.65x64 90 TM2 E => Q 1.587↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.36x36 114 TM3 C => L 2.125↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 3.36x36 114 TM3 C => L 2.615↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.51x51 182 ECL2 S => I 1.059↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.51x51 182 ECL2 S => I 1.619↑ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.52x52 183 ECL2 I => F 16.129↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 45.52x52 183 ECL2 I => F 12.658↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => A 7.042↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => A 8.85↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => I 2.41↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 5.39x40 189 TM5 V => I 1.912↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.35x34 365 TM7 Y => L 3.846↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.35x34 365 TM7 Y => L 3.676↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.43x42 373 TM7 Y => F 4.348↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 7.43x42 373 TM7 Y => F 4.651↓ K(i) (Binding - Radioligand competition/displacement) PF-4363467 Ferruz N et al (2018) Vass M et al (2019)
drd3_human 2.61x60 86 TM2 V => F 2.985↓ K(i) (Binding - Radioligand competition/displacement) paper-1c Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 2.64x63 89 TM2 L => F 1.069↑ K(i) (Binding - Radioligand competition/displacement) paper-1c Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 3.32x32 110 TM3 D => E 1.132↑ K(i) (Binding - Radioligand competition/displacement) paper-1c Ehrlich K et al (2009) Kooistra AJ et al (2013)
drd3_human 6.55x55 349 TM6 H => A 12.623↑ K(i) (Binding - Radioligand competition/displacement) paper-1c Ehrlich K et al (2009) Kooistra AJ et al (2013)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S G H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
G N G F V I A L I L A C Y S L A Y Y A H 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F V D 3 V A L M I T A V W V L A F A V S C P L 4 Y V L V T V G F P L Y F S V V S S Y I V F 5 A I V L G A F I V C W L P F F L T H V L 6 V P N L A S N V Y G L W T T A S Y L E 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
D3 receptor
TM1
1x39 1.39x39 Y36
TM2
2x60 2.61x60 V86
2x63 2.64x63 L89
2x64 2.65x64 E90
TM3
3x24 3.24x24 C102
3x32 3.32x32 D110
3x36 3.36x36 C114
TM5
5x40 5.39x40 V189
5x43 5.42x43 S192
5x44 5.43x44 S193
5x461 5.46x461 S196
TM6
6x34 6.34x34 T328
6x51 6.51x51 F345
6x55 6.55x55 H349
TM7
7x30 7.31x30 S361
7x34 7.35x34 Y365
7x37 7.38x37 T368
7x38 7.39x38 T369
7x42 7.43x42 Y373