Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
drd5_human 6.27x27 288 TM6 I => F N/A N/A Charpentier S et al (1996)
drd5_human 6.29x29 290 TM6 K => R N/A N/A Charpentier S et al (1996)
drd5_human 439 C-term Q => A N/A N/A Demchyshyn LL et al (2000)
drd5_human 439 C-term Q => I N/A N/A Demchyshyn LL et al (2000)
drd5_human 7 N-term N => Q N/A N/A Karpa KD et al (1999)
drd5_human 7 N-term N => T N/A N/A Karpa KD et al (1999)
drd5_human 199 ECL2 N => T N/A N/A Karpa KD et al (1999)
drd5_human 5.35x36 222 TM5 N => Q N/A N/A Karpa KD et al (1999)
drd5_human 9 N-term T => V N/A N/A Karpa KD et al (1999)
drd5_human 2.51x51 88 TM2 L => F N/A N/A Cravchik A et al (1999)
drd5_human 5.82x82 269 TM5 A => V N/A N/A Cravchik A et al (1999)
drd5_human 330 ECL3 P => Q N/A N/A Cravchik A et al (1999)
drd5_human 7.45x45 351 TM7 N => D N/A N/A Cravchik A et al (1999)
drd5_human 453 C-term S => C N/A N/A Cravchik A et al (1999)
drd5_human 7 N-term N => Q N/A N/A Karpa KD et al (1999)
drd5_human 7 N-term N => T N/A N/A Karpa KD et al (1999)
drd5_human 9 N-term T => V N/A N/A Karpa KD et al (1999)
drd5_human 2.51x51 88 TM2 L => F N/A N/A Cravchik A et al (1999)
drd5_human 2.51x51 88 TM2 L => F N/A N/A Feng J et al (1998)
drd5_human 5.35x36 222 TM5 N => Q N/A N/A Karpa KD et al (1999)
drd5_human 5.82x82 269 TM5 A => V N/A N/A Cravchik A et al (1999)
drd5_human 6.27x27 288 TM6 I => F N/A N/A Charpentier S et al (1996)
drd5_human 6.29x29 290 TM6 K => R N/A N/A Charpentier S et al (1996)
drd5_human 330 ECL3 P => Q N/A N/A Cravchik A et al (1999)
drd5_human 7.45x45 351 TM7 N => D N/A N/A Cravchik A et al (1999)
drd5_human 439 C-term Q => A N/A N/A Demchyshyn LL et al (2000)
drd5_human 453 C-term S => C N/A N/A Cravchik A et al (1999)
drd5_human 439 C-term Q => A 2.979↑ K(i) (Binding - Radioligand competition/displacement) (-)-N-porphynorapomorphine Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 3.109↑ K(i) (Binding - Radioligand competition/displacement) (-)-N-porphynorapomorphine Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => A 1.216↑ K(i) (Binding - Radioligand competition/displacement) SKF-38393 Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.127↑ K(i) (Binding - Radioligand competition/displacement) SKF-38393 Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => A 6.242↑ K(i) (Binding - Radioligand competition/displacement) (+)-ADTN Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 6.455↑ K(i) (Binding - Radioligand competition/displacement) (+)-ADTN Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 6.27x27 288 TM6 I => F 1.0 K(d) (Binding - Radioligand saturation) CHEMBL290118 Charpentier S et al (1996) Vass M et al (2019)
drd5_human 6.29x29 290 TM6 K => R 1.0 K(d) (Binding - Radioligand saturation) CHEMBL290118 Charpentier S et al (1996) Vass M et al (2019)
drd5_human 439 C-term Q => A 2.232↑ K(i) (Binding - Radioligand competition/displacement) apomorphine Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.582↑ K(i) (Binding - Radioligand competition/displacement) apomorphine Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => A 1.723↑ K(i) (Binding - Radioligand competition/displacement) haloperidol Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.588↑ K(i) (Binding - Radioligand competition/displacement) haloperidol Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => A 1.5↑ K(i) (Binding - Radioligand competition/displacement) flupentixol Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.5↑ K(i) (Binding - Radioligand competition/displacement) flupentixol Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => A 2.0↑ K(i) (Binding - Radioligand competition/displacement) fenoldopam Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.333↑ K(i) (Binding - Radioligand competition/displacement) fenoldopam Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 6.27x27 288 TM6 I => F 2.778↓ K(i) (Binding - Radioligand competition/displacement) dopamine Charpentier S et al (1996) Vass M et al (2019)
drd5_human 6.29x29 290 TM6 K => R 1.105↑ K(i) (Binding - Radioligand competition/displacement) dopamine Charpentier S et al (1996) Vass M et al (2019)
drd5_human 439 C-term Q => A 3.548↑ K(i) (Binding - Radioligand competition/displacement) dopamine Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 4.4↑ K(i) (Binding - Radioligand competition/displacement) dopamine Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => A 1.174↓ K(d) (Binding - Radioligand saturation) (R)-SCH-23390 Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.575↓ K(d) (Binding - Radioligand saturation) (R)-SCH-23390 Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => A 1.133↑ K(i) (Binding - Radioligand competition/displacement) (R)-SCH-23390 Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.631↓ K(i) (Binding - Radioligand competition/displacement) (R)-SCH-23390 Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => A 2.679↑ K(i) (Binding - Radioligand competition/displacement) chlorpromazine Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.667↑ K(i) (Binding - Radioligand competition/displacement) chlorpromazine Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 6.27x27 288 TM6 I => F 1.021↓ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Charpentier S et al (1996) Vass M et al (2019)
drd5_human 6.29x29 290 TM6 K => R 1.022↑ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Charpentier S et al (1996) Vass M et al (2019)
drd5_human 439 C-term Q => A 1.2↑ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Demchyshyn LL et al (2000) Vass M et al (2019)
drd5_human 439 C-term Q => I 1.059↑ K(i) (Binding - Radioligand competition/displacement) (+)-butaclamol Demchyshyn LL et al (2000) Vass M et al (2019)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R H L R A ICL1ECL1 Y W P F ECL1ICL2 P F R Y K R K M ICL2ECL2 W H R D Q A A S W G G L D L P N N L A N W T P W E E D F W E P D V N A E N C D S S L ECL2ICL3 S S A A C A P D T S L ICL3ECL3 S G H P E G P P A G F P C V ECL3N-term M L P P G S N G T A Y P G Q F A L Y Q Q L A Q G N A V G G S A G A P P L G N-termC-term C S H F C S R T P V E T V N I S N E L I S Y N Q D I V F H K E I A A A Y I H M M P N A V T P G N R E V D N D E E E G P F D R M F Q I Y Q T S P D G D P V A E S V W E L D C E G E I S L D K I T P F T P N G F H C-term P S Q V V T A C L L T L L I I W T L L G N V L V C A A I V R S N M T N V F I V S L A V S D L F V A L L V M P W K A V A E V A G G A F C D V W V A F D I M C S T A S I L N L C V I S V D R Y W A I S R T Q R M A L V M V G L A W T L S I L I S F I P V Q L N N R T Y A I S S S L I S F Y I P V A I M I V T Y T R I Y R I A Q V Q I R R I S S L E R A A E H A Q S C R R A S I K K E T K V L K T L S V I M G V F V C C W L P F F I L N C M V P F C S E T T F D V F V W F G W A N S S L N P V I Y A F N A D F A Q F Q K V L L G
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
V N G L L T W I I L L T L L C A T V V Q 1 V S L A V S D L F V A L L V M P W K A V A 2 V C L N L I S A T S C M I D F A V W V D 3 A L V M V G L A W T L S I L I S F I P V 4 Y T V I M I A V P I Y F S I L S S S I A Y 5 S V I M G V F V C C W L P F F I L N C M 6 V P N L S S N A W G F W V F V D F T T 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
D5 receptor
TM2
2x51 2.51x51 L88
TM5
5x36 5.35x36 N222
5x82 5.82x82 A269
TM6
6x27 6.27x27 I288
6x29 6.29x29 K290
TM7
7x45 7.45x45 N351