Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
mc4r_human 7.49x49 298 TM7 D => N 1.828↓ IC50 (Binding - Radioligand competition/displacement) afamelanotide N/A
mc4r_human 7.49x49 298 TM7 D => N 7.937↓ EC50 (Functional - cAMP accumulation) afamelanotide N/A
mc4r_human 7.49x49 298 TM7 D => N 1.351↑ IC50 (Binding - Radioligand competition/displacement) agouti-related protein N/A
mc4r_human 7 N-term R => C 1.068↑ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 2.44x44 84 TM2 C => R Abolished IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 3.30x30 127 TM3 S => L 1.139↓ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => F 3.538↑ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 4.50x50 174 TM4 W => C Abolished IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 5.65x65 219 TM5 A => V 1.529↓ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 230 ICL3 P => L 1.027↑ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 6.51x51 261 TM6 F => S 5.285↑ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 8.58x58 317 H8 I => V 1.401↓ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 325 C-term L => F 2.57↑ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 7 N-term R => C 2.506↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 2.44x44 84 TM2 C => R 7.143↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 3.30x30 127 TM3 S => L 1.46↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => F 6.25↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 4.50x50 174 TM4 W => C 12.195↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 5.65x65 219 TM5 A => V 20.0↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 230 ICL3 P => L 10.101↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 6.51x51 261 TM6 F => S 1.214↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 8.58x58 317 H8 I => V 2.95↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 325 C-term L => F 2.146↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 7 N-term R => C 1.156↑ IC50 (Binding - Radioligand competition/displacement) agouti-related protein Fan ZC et al (2009)
mc4r_human 3.30x30 127 TM3 S => L 4.386↓ IC50 (Binding - Radioligand competition/displacement) agouti-related protein Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => F 10.146↑ IC50 (Binding - Radioligand competition/displacement) agouti-related protein Fan ZC et al (2009)
mc4r_human 5.65x65 219 TM5 A => V 3.086↓ IC50 (Binding - Radioligand competition/displacement) agouti-related protein Fan ZC et al (2009)
mc4r_human 230 ICL3 P => L 1.037↑ IC50 (Binding - Radioligand competition/displacement) agouti-related protein Fan ZC et al (2009)
mc4r_human 6.51x51 261 TM6 F => S 3.128↑ IC50 (Binding - Radioligand competition/displacement) agouti-related protein Fan ZC et al (2009)
mc4r_human 8.58x58 317 H8 I => V 1.169↑ IC50 (Binding - Radioligand competition/displacement) agouti-related protein Fan ZC et al (2009)
mc4r_human 325 C-term L => F 1.484↓ IC50 (Binding - Radioligand competition/displacement) agouti-related protein Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => A 1.015↑ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => C 1.481↓ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => D 1.06↓ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => L 1.151↑ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => R 6.024↓ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => T 1.736↓ IC50 (Binding - Radioligand competition/displacement) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => A 5.376↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => C 1.402↑ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => D 1.901↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => L 6.897↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => R 7.143↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 3.39x39 136 TM3 S => T 1.634↓ EC50 (Functional - cAMP accumulation) afamelanotide Fan ZC et al (2009)
mc4r_human 12.51x51 76 ICL1 H => R 40.771↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 2.39x39 79 TM2 M => I 5.13↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 2.54x54 94 TM2 S => N 31.364↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 3.49x49 146 TM3 D => N 381.912↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 4.62x62 186 TM4 I => V 1.553↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 5.41x41 195 TM5 I => S 5.118↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 5.47x47 201 TM5 F => L 1.376↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 231 ICL3 G => V 2.259↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 280 ECL3 F => L 11.221↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 7.40x39 289 TM7 I => L 1.109↓ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 7.51x51 300 TM7 L => P 31.422↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 7.56x56 305 TM7 R => S 1.344↓ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 332 C-term Y => C 1.76↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 332 C-term Y => H 1.006↑ IC50 (Binding - Radioligand competition/displacement) INTERMEDINE N/A
mc4r_human 12.51x51 76 ICL1 H => R 2.815↑ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 2.39x39 79 TM2 M => I 58.824↓ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 2.54x54 94 TM2 S => N 2.033↓ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 3.49x49 146 TM3 D => N 32.375↑ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 4.62x62 186 TM4 I => V 4.317↑ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 5.41x41 195 TM5 I => S 1.2↓ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 5.47x47 201 TM5 F => L 3.247↓ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 231 ICL3 G => V 1.489↑ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 280 ECL3 F => L 4.047↑ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 7.40x39 289 TM7 I => L 4.709↑ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 7.51x51 300 TM7 L => P 1.274↓ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 7.56x56 305 TM7 R => S 3.378↓ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 332 C-term Y => C 7.618↑ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 332 C-term Y => H 3.408↑ EC50 (Functional - cAMP accumulation) INTERMEDINE N/A
mc4r_human 12.51x51 76 ICL1 H => R 13.529↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 2.39x39 79 TM2 M => I 2.381↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 2.54x54 94 TM2 S => N 6.286↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 3.49x49 146 TM3 D => N 22.57↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 4.62x62 186 TM4 I => V 1.361↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 5.41x41 195 TM5 I => S 2.538↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 5.47x47 201 TM5 F => L 1.737↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 231 ICL3 G => V 1.039↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 280 ECL3 F => L 2.808↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 7.40x39 289 TM7 I => L 1.524↓ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 7.51x51 300 TM7 L => P 4.396↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 7.56x56 305 TM7 R => S 1.135↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 332 C-term Y => C 1.81↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 332 C-term Y => H 1.543↑ IC50 (Binding - Radioligand competition/displacement) Beta-MSH N/A
mc4r_human 12.51x51 76 ICL1 H => R 2.746↑ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 2.39x39 79 TM2 M => I 90.909↓ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 2.54x54 94 TM2 S => N 2.262↓ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 3.49x49 146 TM3 D => N 6.894↑ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 4.62x62 186 TM4 I => V 3.057↑ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 5.41x41 195 TM5 I => S 1.321↓ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 5.47x47 201 TM5 F => L 1.637↓ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 231 ICL3 G => V 1.831↑ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 280 ECL3 F => L 1.929↑ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 7.40x39 289 TM7 I => L 2.571↑ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 7.51x51 300 TM7 L => P 1.799↓ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 7.56x56 305 TM7 R => S 2.137↓ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 332 C-term Y => C 2.09↑ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 332 C-term Y => H 1.276↑ EC50 (Functional - cAMP accumulation) Beta-MSH N/A
mc4r_human 2.44x44 84 TM2 C => A 1.101↑ IC50 (Binding - Radioligand competition/displacement) afamelanotide N/A
mc4r_human 8.59x59 318 H8 C => A 1.078↑ K(d) (Binding - Radioligand competition/displacement) afamelanotide N/A
mc4r_human 3.29x29 126 TM3 D => C Abolished K(d) (Binding - Radioligand competition/displacement) afamelanotide N/A
mc4r_human 7.43x42 292 TM7 M => C Abolished K(d) (Binding - Radioligand competition/displacement) afamelanotide N/A
mc4r_human 8.59x59 318 H8 C => A Abolished pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 3.29x29 126 TM3 D => C N/A pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 7.43x42 292 TM7 M => C Abolished pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 2.66x66 106 TM2 L => C 3.546↓ pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 3.25x25 122 TM3 D => C Abolished pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 3.28x28 125 TM3 I => C 1.949↓ pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 3.29x29 126 TM3 D => C N/A pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 6.54x54 264 TM6 H => C 333.333↓ pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 7.43x42 292 TM7 M => C Abolished pEC50 (Functional - CRE-luciferase) afamelanotide N/A
mc4r_human 1.50x50 62 TM1 N => S Decreased (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 2.57x57 97 TM2 N => D Abolished (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 2.66x66 106 TM2 L => P Abolished (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 3.28x28 125 TM3 I => K Abolished (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 4.41x41 165 TM4 R => Q Decreased (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 4.51x51 175 TM4 A => T Decreased (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 6.43x43 253 TM6 V => I Decreased (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 6.61x61 271 TM6 C => Y Abolished (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 8.57x57 316 H8 I => S Decreased (Functional - cAMP accumulation) INTERMEDINE Yeo GS et al (2003)
mc4r_human 1.50x50 62 TM1 N => S 5.0↓ (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 2.57x57 97 TM2 N => D 9.524↓ (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 2.66x66 106 TM2 L => P 5.348↓ (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 3.28x28 125 TM3 I => K 7.407↓ (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 4.41x41 165 TM4 R => Q 3.344↓ (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 4.51x51 175 TM4 A => T 1.656↓ (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 6.43x43 253 TM6 V => I 1.245↓ (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 6.61x61 271 TM6 C => Y Abolished (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 8.57x57 316 H8 I => S 3.571↓ (Binding - Radioligand competition/displacement) INTERMEDINE Yeo GS et al (2003)
mc4r_human 1.37x37 49 TM1 E => A 1.429↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 1.49x49 61 TM1 E => A 2.625↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 2.50x50 90 TM2 D => A 3.636↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 2.60x60 100 TM2 E => A 4.348↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => A 6.061↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => N 3.61↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => A N/A K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => N N/A K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 3.33x33 130 TM3 C => A 1.832↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 4.40x40 164 TM4 K => A 1.124↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 4.41x41 165 TM4 R => A 1.318↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 5.42x42 196 TM5 C => A 2.012↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 5.45x45 199 TM5 T => A 1.038↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 5.46x46 200 TM5 M => A 1.961↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 5.49x49 203 TM5 T => A 1.37↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 5.50x50 204 TM5 M => A 1.499↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 5.60x60 214 TM5 H => A 1.092↑ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 6.48x48 258 TM6 W => A 2.604↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 6.51x51 261 TM6 F => A 5.405↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 6.54x54 264 TM6 H => A N/A K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 6.57x57 267 TM6 F => A 1.072↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 6.58x58 268 TM6 Y => A 1.214↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 7.34x33 283 TM7 H => A 1.387↑ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 7.36x35 285 TM7 N => A 1.637↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 7.49x49 298 TM7 D => A 2.95↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 7.56x56 305 TM7 R => A 1.233↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 1.37x37 49 TM1 E => A 2.439↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 1.49x49 61 TM1 E => A 2.096↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 2.50x50 90 TM2 D => A 10.638↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 2.60x60 100 TM2 E => A 3.846↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => A 21.277↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => N 3.774↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => A Abolished K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => N Abolished K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.33x33 130 TM3 C => A 1.212↑ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 4.40x40 164 TM4 K => A 1.024↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 4.41x41 165 TM4 R => A 1.59↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.42x42 196 TM5 C => A 1.11↑ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.45x45 199 TM5 T => A 1.242↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.46x46 200 TM5 M => A 16.949↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.49x49 203 TM5 T => A 1.321↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.50x50 204 TM5 M => A >333.333↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.60x60 214 TM5 H => A 1.248↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.48x48 258 TM6 W => A 22.727↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.51x51 261 TM6 F => A 4.673↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.54x54 264 TM6 H => A Abolished K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.57x57 267 TM6 F => A 1.559↑ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.58x58 268 TM6 Y => A 2.144↑ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 7.34x33 283 TM7 H => A 1.27↑ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 7.36x35 285 TM7 N => A 1.058↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 7.49x49 298 TM7 D => A 2.315↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 7.56x56 305 TM7 R => A 2.639↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Yang YK et al (2000)
mc4r_human 1.37x37 49 TM1 E => A 1.312↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 1.49x49 61 TM1 E => A 1.458↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 2.50x50 90 TM2 D => A 1.057↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 2.60x60 100 TM2 E => A 1.346↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => A 1.661↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => N 1.35↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => A 8.929↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => N 5.376↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 3.33x33 130 TM3 C => A 1.119↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 4.40x40 164 TM4 K => A 1.319↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 4.41x41 165 TM4 R => A 1.057↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 5.42x42 196 TM5 C => A 1.078↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 5.45x45 199 TM5 T => A 1.18↑ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 5.46x46 200 TM5 M => A 1.05↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 5.49x49 203 TM5 T => A 1.379↑ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 5.50x50 204 TM5 M => A 1.135↑ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 5.60x60 214 TM5 H => A 1.119↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 6.48x48 258 TM6 W => A 1.277↑ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 6.51x51 261 TM6 F => A 1.35↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 6.54x54 264 TM6 H => A 1.389↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 6.57x57 267 TM6 F => A 1.553↑ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 6.58x58 268 TM6 Y => A 1.221↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 7.34x33 283 TM7 H => A 1.305↑ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 7.36x35 285 TM7 N => A 1.117↑ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 7.49x49 298 TM7 D => A 1.01↓ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 7.56x56 305 TM7 R => A 1.093↑ K(i) (Binding - Radioligand competition/displacement) agouti-related protein Yang YK et al (2000)
mc4r_human 1.37x37 49 TM1 E => A 1.555↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 1.49x49 61 TM1 E => A 1.89↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 2.50x50 90 TM2 D => A Abolished EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 2.60x60 100 TM2 E => A 2.41↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => A 6.173↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => N 2.558↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => A N/A EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => N 1000.0↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 3.33x33 130 TM3 C => A 1.742↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 4.40x40 164 TM4 K => A 1.629↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 4.41x41 165 TM4 R => A 1.222↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 5.42x42 196 TM5 C => A 1.555↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 5.45x45 199 TM5 T => A 1.074↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 5.46x46 200 TM5 M => A 1.667↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 5.49x49 203 TM5 T => A 1.222↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 5.50x50 204 TM5 M => A 2.0↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 5.60x60 214 TM5 H => A 1.5↑ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 6.48x48 258 TM6 W => A 2.0↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 6.51x51 261 TM6 F => A 3.922↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 6.54x54 264 TM6 H => A 500.0↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 6.57x57 267 TM6 F => A 1.37↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 6.58x58 268 TM6 Y => A 1.852↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 7.34x33 283 TM7 H => A 1.0 EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 7.36x35 285 TM7 N => A 1.174↑ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 7.49x49 298 TM7 D => A Abolished EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 7.56x56 305 TM7 R => A 1.815↓ EC50 (Functional - cAMP accumulation) afamelanotide Yang YK et al (2000)
mc4r_human 1.37x37 49 TM1 E => A 1.77↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 1.49x49 61 TM1 E => A 4.566↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 2.50x50 90 TM2 D => A Abolished EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 2.60x60 100 TM2 E => A 3.322↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => A N/A EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => N 111.111↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => A Abolished EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => N Abolished EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.33x33 130 TM3 C => A 1.089↑ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 4.40x40 164 TM4 K => A 1.866↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 4.41x41 165 TM4 R => A 2.315↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.42x42 196 TM5 C => A 1.761↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.45x45 199 TM5 T => A 1.866↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.46x46 200 TM5 M => A 6.803↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.49x49 203 TM5 T => A 1.314↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.50x50 204 TM5 M => A 4.255↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 5.60x60 214 TM5 H => A 1.792↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.48x48 258 TM6 W => A 11.905↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.51x51 261 TM6 F => A 4.049↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.54x54 264 TM6 H => A N/A EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.57x57 267 TM6 F => A 2.165↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 6.58x58 268 TM6 Y => A 66.667↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 7.34x33 283 TM7 H => A 1.894↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 7.36x35 285 TM7 N => A 1.77↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 7.49x49 298 TM7 D => A Abolished EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 7.56x56 305 TM7 R => A 1.023↑ EC50 (Functional - cAMP accumulation) INTERMEDINE Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => A 7.143↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => A 21.739↓ K(i) (Binding - Radioligand competition/displacement) afamelanotide Yang YK et al (2000)
mc4r_human 2.66x66 106 TM2 L => P Decreased EC50 (Functional - cAMP accumulation) INTERMEDINE Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 1000.0↓ EC50 (Functional - cAMP accumulation) CHEMBL412536 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 37.037↓ EC50 (Functional - cAMP accumulation) [D-Trp8]γ-MSH Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P Decreased EC50 (Functional - cAMP accumulation) ACTH-(1-24) Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 83.333↓ EC50 (Functional - cAMP accumulation) JRH887-9 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 111.111↓ EC50 (Functional - cAMP accumulation) EMH4-91 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 5.319↓ EC50 (Functional - cAMP accumulation) EMH4-92 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 90.909↓ EC50 (Functional - cAMP accumulation) EMH4-93 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 31.25↓ EC50 (Functional - cAMP accumulation) EMH4-94 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 66.667↓ EC50 (Functional - cAMP accumulation) EMH4-95 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 166.667↓ EC50 (Functional - cAMP accumulation) EMH4-96 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 125.0↓ EC50 (Functional - cAMP accumulation) EMH4-97 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 166.667↓ EC50 (Functional - cAMP accumulation) EMH4-98 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 333.333↓ EC50 (Functional - cAMP accumulation) EMH4-99 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P >33.333↓ EC50 (Functional - cAMP accumulation) EMH4-100 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 90.909↓ EC50 (Functional - cAMP accumulation) EMH4-101 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 66.667↓ EC50 (Functional - cAMP accumulation) EMH4-102 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 22.727↓ EC50 (Functional - cAMP accumulation) EMH4-103 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 166.667↓ EC50 (Functional - cAMP accumulation) EMH4-104 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 76.923↓ EC50 (Functional - cAMP accumulation) EMH4-105 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P >50.0↓ EC50 (Functional - cAMP accumulation) EMH4-106 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 1.0 EC50 (Functional - cAMP accumulation) EMH4-107 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 125.0↓ EC50 (Functional - cAMP accumulation) EMH4-108 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P >52.632↓ EC50 (Functional - cAMP accumulation) EMH4-109 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 142.857↓ EC50 (Functional - cAMP accumulation) EMH4-110 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 200.0↓ EC50 (Functional - cAMP accumulation) JRH887-9 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 43.478↓ EC50 (Functional - cAMP accumulation) JRH887-9 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 1000.0↓ EC50 (Functional - cAMP accumulation) JRH887-9 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 10.526↓ EC50 (Functional - cAMP accumulation) JRH887-9 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y 1000.0↓ EC50 (Functional - cAMP accumulation) JRH887-9 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R 1000.0↓ EC50 (Functional - cAMP accumulation) JRH887-9 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 41.667↓ EC50 (Functional - cAMP accumulation) CMPD4 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 15.873↓ EC50 (Functional - cAMP accumulation) CMPD4 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 58.824↓ EC50 (Functional - cAMP accumulation) CMPD4 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 18.868↓ EC50 (Functional - cAMP accumulation) CMPD4 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y 1000.0↓ EC50 (Functional - cAMP accumulation) CMPD4 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R 1000.0↓ EC50 (Functional - cAMP accumulation) CMPD4 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 20.833↓ EC50 (Functional - cAMP accumulation) CMPD5 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 10.753↓ EC50 (Functional - cAMP accumulation) CMPD5 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 28.571↓ EC50 (Functional - cAMP accumulation) CMPD5 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 22.727↓ EC50 (Functional - cAMP accumulation) CMPD5 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y N/A EC50 (Functional - cAMP accumulation) CMPD5 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R N/A EC50 (Functional - cAMP accumulation) CMPD5 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 10.0↓ EC50 (Functional - cAMP accumulation) CMPD6 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 15.873↓ EC50 (Functional - cAMP accumulation) CMPD6 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 11.111↓ EC50 (Functional - cAMP accumulation) CMPD6 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 23.256↓ EC50 (Functional - cAMP accumulation) CMPD6 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y N/A EC50 (Functional - cAMP accumulation) CMPD6 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R N/A EC50 (Functional - cAMP accumulation) CMPD6 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 15.152↓ EC50 (Functional - cAMP accumulation) CMPD7 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 11.765↓ EC50 (Functional - cAMP accumulation) CMPD7 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 12.048↓ EC50 (Functional - cAMP accumulation) CMPD7 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 47.619↓ EC50 (Functional - cAMP accumulation) CMPD7 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y N/A EC50 (Functional - cAMP accumulation) CMPD7 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R N/A EC50 (Functional - cAMP accumulation) CMPD7 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 37.037↓ EC50 (Functional - cAMP accumulation) CMPD8 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 10.753↓ EC50 (Functional - cAMP accumulation) CMPD8 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 7.519↓ EC50 (Functional - cAMP accumulation) CMPD8 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 6.993↓ EC50 (Functional - cAMP accumulation) CMPD8 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y 200.0↓ EC50 (Functional - cAMP accumulation) CMPD8 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R 333.333↓ EC50 (Functional - cAMP accumulation) CMPD8 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 22.222↓ EC50 (Functional - cAMP accumulation) CMPD9 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 6.452↓ EC50 (Functional - cAMP accumulation) CMPD9 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 45.455↓ EC50 (Functional - cAMP accumulation) CMPD9 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 13.514↓ EC50 (Functional - cAMP accumulation) CMPD9 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y 500.0↓ EC50 (Functional - cAMP accumulation) CMPD9 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R 500.0↓ EC50 (Functional - cAMP accumulation) CMPD9 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 16.129↓ EC50 (Functional - cAMP accumulation) CMPD10 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 25.0↓ EC50 (Functional - cAMP accumulation) CMPD10 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 20.833↓ EC50 (Functional - cAMP accumulation) CMPD10 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 20.0↓ EC50 (Functional - cAMP accumulation) CMPD10 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y N/A EC50 (Functional - cAMP accumulation) CMPD10 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R N/A EC50 (Functional - cAMP accumulation) CMPD10 Haslach EM et al (2014)
mc4r_human 2.66x66 106 TM2 L => P 66.667↓ EC50 (Functional - cAMP accumulation) CMPD11 Haslach EM et al (2014)
mc4r_human 1.57x57 69 TM1 I => T 43.478↓ EC50 (Functional - cAMP accumulation) CMPD11 Haslach EM et al (2014)
mc4r_human 2.62x62 102 TM2 I => S 66.667↓ EC50 (Functional - cAMP accumulation) CMPD11 Haslach EM et al (2014)
mc4r_human 5.65x65 219 TM5 A => V 90.909↓ EC50 (Functional - cAMP accumulation) CMPD11 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => Y N/A EC50 (Functional - cAMP accumulation) CMPD11 Haslach EM et al (2014)
mc4r_human 6.61x61 271 TM6 C => R N/A EC50 (Functional - cAMP accumulation) CMPD11 Haslach EM et al (2014)
mc4r_human 30 N-term S => F 2.217↑ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 2.38x38 78 TM2 P => L 11.236↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 2.55x55 95 TM2 V => I Abolished EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 112 ECL1 T => M Unchanged EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 3.24x24 121 TM3 I => T 10.204↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 3.30x30 127 TM3 S => L 76.923↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 4.57x57 181 TM4 G => D Abolished EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 230 ICL3 P => L 2.096↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 6.34x34 244 TM6 A => E 8.333↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 6.42x42 252 TM6 G => S 1.378↑ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 8.58x58 317 H8 I => T 1.117↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 2.63x63 103 TM2 V => I 1.759↑ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 2.54x54 94 TM2 S => R Abolished EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 4.54x54 178 TM4 T => M 1.764↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Hinney A et al (2003)
mc4r_human 2.62x62 102 TM2 I => S 10.0↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => S 6.623↓ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => S 1.183↓ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 18 N-term R => C 1.625↑ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 18 N-term R => C 1.919↑ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 18 N-term R => C 1.092↑ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 18 N-term R => H 1.625↑ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 18 N-term R => H 1.449↑ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 18 N-term R => H 1.69↑ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 1.38x38 50 TM1 V => M 1.182↑ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 1.38x38 50 TM1 V => M 1.112↓ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 1.38x38 50 TM1 V => M 1.127↑ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 231 ICL3 G => S 1.076↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 231 ICL3 G => S 1.224↑ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 231 ICL3 G => S 1.044↑ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 3.30x30 127 TM3 S => L 6.135↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 3.30x30 127 TM3 S => L 4.651↓ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 3.30x30 127 TM3 S => L 3.663↓ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 1.46x46 58 TM1 S => C 2.037↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 1.46x46 58 TM1 S => C 2.392↓ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 1.46x46 58 TM1 S => C 1.366↓ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => T 8.065↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => T 3.096↓ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => T 1.198↓ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 6.42x42 252 TM6 G => S 6.135↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 6.42x42 252 TM6 G => S 3.236↓ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 6.42x42 252 TM6 G => S 2.252↓ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 7.56x56 305 TM7 R => W 5.0↓ K(i) (Binding - Radioligand competition/displacement) INTERMEDINE Roubert P et al (2010)
mc4r_human 7.56x56 305 TM7 R => W 3.521↓ K(i) (Binding - Radioligand competition/displacement) setmelanotide Roubert P et al (2010)
mc4r_human 7.56x56 305 TM7 R => W 3.096↓ K(i) (Binding - Radioligand competition/displacement) IRC-022511 Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => S >333.333↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => S 66.667↓ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => S 30.303↓ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 7.50x50 299 TM7 P => H Abolished EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 7.50x50 299 TM7 P => H Abolished EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 7.50x50 299 TM7 P => H Abolished EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 18 N-term R => C 1.134↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 18 N-term R => C 1.267↓ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 18 N-term R => C 1.314↓ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 18 N-term R => H 1.875↑ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 18 N-term R => H 1.613↑ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 18 N-term R => H 1.628↑ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 1.38x38 50 TM1 V => M 1.233↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 1.38x38 50 TM1 V => M 1.333↓ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 1.38x38 50 TM1 V => M 1.372↓ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 231 ICL3 G => S 1.1↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 231 ICL3 G => S 1.267↓ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 231 ICL3 G => S 1.129↓ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 3.30x30 127 TM3 S => L 21.277↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 3.30x30 127 TM3 S => L 11.364↓ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 3.30x30 127 TM3 S => L 7.407↓ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 1.46x46 58 TM1 S => C 22.222↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 1.46x46 58 TM1 S => C 30.303↓ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 1.46x46 58 TM1 S => C 27.027↓ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => T 200.0↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => T 100.0↓ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 2.62x62 102 TM2 I => T 55.556↓ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 6.42x42 252 TM6 G => S 6.993↓ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 6.42x42 252 TM6 G => S 8.696↓ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 6.42x42 252 TM6 G => S 11.494↓ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 7.56x56 305 TM7 R => W 2.0↑ EC50 (Functional - cAMP accumulation) INTERMEDINE Roubert P et al (2010)
mc4r_human 7.56x56 305 TM7 R => W 1.724↑ EC50 (Functional - cAMP accumulation) setmelanotide Roubert P et al (2010)
mc4r_human 7.56x56 305 TM7 R => W 1.148↑ EC50 (Functional - cAMP accumulation) IRC-022511 Roubert P et al (2010)
mc4r_human 6.57x57 267 TM6 F => L N/A N/A Oosterom J et al (1999)
mc4r_human 6.58x58 268 TM6 Y => I N/A N/A Oosterom J et al (1999)
mc4r_human 6.60x60 270 TM6 S => T N/A N/A Oosterom J et al (1999)
mc4r_human 273 ECL3 Q => T N/A N/A Oosterom J et al (1999)
mc4r_human 281 ECL3 M => T N/A N/A Oosterom J et al (1999)
mc4r_human 6 N-term H => A N/A N/A Yang YK et al (2000)
mc4r_human 6 N-term H => R N/A N/A Pogozheva ID et al (2005)
mc4r_human 11 N-term T => A N/A N/A Branson R et al (2003)
mc4r_human 11 N-term T => A N/A N/A Tao YX et al (2005)
mc4r_human 11 N-term T => S N/A N/A Vaisse C et al (2000)
mc4r_human 11 N-term T => S N/A N/A Nijenhuis WA et al (2003)
mc4r_human 18 N-term R => C N/A N/A Vaisse C et al (2000)
mc4r_human 18 N-term R => C N/A N/A Nijenhuis WA et al (2003)
mc4r_human 30 N-term S => F N/A N/A Chen D et al (1999)
mc4r_human 30 N-term S => F N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 30 N-term S => F N/A N/A Nijenhuis WA et al (2003)
mc4r_human 30 N-term S => P N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 35 N-term Y => X N/A N/A Buono P et al (2005)
mc4r_human 37 N-term D => V N/A N/A Chen D et al (1999)
mc4r_human 37 N-term D => V N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 37 N-term D => V N/A N/A Nijenhuis WA et al (2003)
mc4r_human 37 N-term D => V N/A N/A Tao YX et al (2003)
mc4r_human 1.36x36 48 TM1 P => S N/A N/A Tao YX et al (2003)
mc4r_human 1.37x37 49 TM1 E => A N/A N/A Yang YK et al (2000)
mc4r_human 1.38x38 50 TM1 V => M N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 1.38x38 50 TM1 V => M N/A N/A Tao YX et al (2003)
mc4r_human 1.39x39 51 TM1 F => L N/A N/A Branson R et al (2003)
mc4r_human 1.39x39 51 TM1 F => L N/A N/A Tao YX et al (2005)
mc4r_human 1.46x46 58 TM1 S => C N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 1.46x46 58 TM1 S => C N/A N/A Tao YX et al (2003)
mc4r_human 1.49x49 61 TM1 E => A N/A N/A Yang YK et al (2000)
mc4r_human 1.50x50 62 TM1 N => S N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 1.50x50 62 TM1 N => S N/A N/A VanLeeuwen D et al (2003)
mc4r_human 1.50x50 62 TM1 N => S N/A N/A Nijenhuis WA et al (2003)
mc4r_human 1.50x50 62 TM1 N => S N/A N/A Tao YX et al (2003)
mc4r_human 2.38x38 78 TM2 P => L N/A N/A Chen D et al (1999)
mc4r_human 2.38x38 78 TM2 P => L N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 2.38x38 78 TM2 P => L N/A N/A Nijenhuis WA et al (2003)
mc4r_human 2.38x38 78 TM2 P => L N/A N/A Tao YX et al (2003)
mc4r_human 2.50x50 90 TM2 D => A N/A N/A Yang YK et al (2000)
mc4r_human 2.58x58 98 TM2 G => R N/A N/A Tao YX et al (2003)
mc4r_human 2.60x60 100 TM2 E => A N/A N/A Yang YK et al (2000)
mc4r_human 2.62x62 102 TM2 I => S N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 2.62x62 102 TM2 I => S N/A N/A Tao YX et al (2005)
mc4r_human 2.62x62 102 TM2 I => T N/A N/A Tao YX et al (2005)
mc4r_human 2.63x63 103 TM2 V => I N/A N/A Tao YX et al (2005)
mc4r_human 112 ECL1 T => M N/A N/A Chen D et al (1999)
mc4r_human 112 ECL1 T => M N/A N/A Vaisse C et al (2000)
mc4r_human 112 ECL1 T => M N/A N/A Branson R et al (2003)
mc4r_human 112 ECL1 T => M N/A N/A Nijenhuis WA et al (2003)
mc4r_human 112 ECL1 T => M N/A N/A Tao YX et al (2005)
mc4r_human 3.25x25 122 TM3 D => A N/A N/A Yang YK et al (2000)
mc4r_human 3.25x25 122 TM3 D => A N/A N/A Nickolls SA et al (2003)
mc4r_human 3.25x25 122 TM3 D => N N/A N/A Yang YK et al (2000)
mc4r_human 3.28x28 125 TM3 I => F N/A N/A Nickolls SA et al (2003)
mc4r_human 3.29x29 126 TM3 D => A N/A N/A Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => A N/A N/A Pogozheva ID et al (2005)
mc4r_human 3.29x29 126 TM3 D => L N/A N/A Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => N N/A N/A Yang YK et al (2000)
mc4r_human 3.29x29 126 TM3 D => S N/A N/A Yang YK et al (2000)
mc4r_human 3.30x30 127 TM3 S => L N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 3.32x32 129 TM3 I => A N/A N/A Pogozheva ID et al (2005)
mc4r_human 3.33x33 130 TM3 C => A N/A N/A Yang YK et al (2000)
mc4r_human 3.40x40 137 TM3 I => T N/A N/A Vaisse C et al (2000)
mc4r_human 3.40x40 137 TM3 I => T N/A N/A Nickolls SA et al (2003)
mc4r_human 3.40x40 137 TM3 I => T N/A N/A Nijenhuis WA et al (2003)
mc4r_human 3.53x53 150 TM3 T => I N/A N/A Vaisse C et al (2000)
mc4r_human 3.53x53 150 TM3 T => I N/A N/A Nijenhuis WA et al (2003)
mc4r_human 34.50x50 154 ICL2 A => D N/A N/A Tao YX et al (2005)
mc4r_human 34.53x53 157 ICL2 Y => S N/A N/A Tao YX et al (2003)
mc4r_human 4.40x40 164 TM4 K => A N/A N/A Yang YK et al (2000)
mc4r_human 4.41x41 165 TM4 R => A N/A N/A Yang YK et al (2000)
mc4r_human 4.41x41 165 TM4 R => Q N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 4.41x41 165 TM4 R => Q N/A N/A Nijenhuis WA et al (2003)
mc4r_human 4.41x41 165 TM4 R => W N/A N/A Chen D et al (1999)
mc4r_human 4.41x41 165 TM4 R => W N/A N/A Vaisse C et al (2000)
mc4r_human 4.41x41 165 TM4 R => W N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 4.41x41 165 TM4 R => W N/A N/A Nijenhuis WA et al (2003)
mc4r_human 4.46x46 170 TM4 I => V N/A N/A Vaisse C et al (2000)
mc4r_human 4.46x46 170 TM4 I => V N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 4.46x46 170 TM4 I => V N/A N/A Nijenhuis WA et al (2003)
mc4r_human 4.46x46 170 TM4 I => V N/A N/A Tao YX et al (2003)
mc4r_human 4.60x60 184 TM4 F => L N/A N/A Nickolls SA et al (2003)
mc4r_human 4.60x60 184 TM4 F => M N/A N/A Nickolls SA et al (2003)
mc4r_human 4.60x60 184 TM4 F => S N/A N/A Nickolls SA et al (2003)
mc4r_human 5.36x36 190 TM5 S => A N/A N/A Nickolls SA et al (2003)
mc4r_human 5.37x37 191 TM5 S => A N/A N/A Nickolls SA et al (2003)
mc4r_human 5.42x42 196 TM5 C => A N/A N/A Yang YK et al (2000)
mc4r_human 5.45x45 199 TM5 T => A N/A N/A Yang YK et al (2000)
mc4r_human 5.46x46 200 TM5 M => A N/A N/A Yang YK et al (2000)
mc4r_human 5.46x46 200 TM5 M => V N/A N/A Branson R et al (2003)
mc4r_human 5.46x46 200 TM5 M => V N/A N/A Tao YX et al (2005)
mc4r_human 5.48x48 202 TM5 F => L N/A N/A Tao YX et al (2005)
mc4r_human 5.49x49 203 TM5 T => A N/A N/A Yang YK et al (2000)
mc4r_human 5.50x50 204 TM5 M => A N/A N/A Yang YK et al (2000)
mc4r_human 5.60x60 214 TM5 H => A N/A N/A Yang YK et al (2000)
mc4r_human 6.30x30 240 TM6 N => S N/A N/A Tao YX et al (2005)
mc4r_human 6.34x34 244 TM6 A => E N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 6.40x40 250 TM6 L => Q N/A N/A Vaisse C et al (2000)
mc4r_human 6.40x40 250 TM6 L => Q N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 6.40x40 250 TM6 L => Q N/A N/A Nijenhuis WA et al (2003)
mc4r_human 6.40x40 250 TM6 L => Q N/A N/A Tao YX et al (2005)
mc4r_human 6.41x41 251 TM6 I => L N/A N/A Chen D et al (1999)
mc4r_human 6.41x41 251 TM6 I => L N/A N/A Vaisse C et al (2000)
mc4r_human 6.41x41 251 TM6 I => L N/A N/A Tao YX et al (2005)
mc4r_human 6.42x42 252 TM6 G => S N/A N/A Chen D et al (1999)
mc4r_human 6.42x42 252 TM6 G => S N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 6.42x42 252 TM6 G => S N/A N/A Nijenhuis WA et al (2003)
mc4r_human 6.43x43 253 TM6 V => I N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 6.43x43 253 TM6 V => I N/A N/A Nijenhuis WA et al (2003)
mc4r_human 6.48x48 258 TM6 W => A N/A N/A Yang YK et al (2000)
mc4r_human 6.48x48 258 TM6 W => A N/A N/A Pogozheva ID et al (2005)
mc4r_human 6.51x51 261 TM6 F => A N/A N/A Yang YK et al (2000)
mc4r_human 6.51x51 261 TM6 F => A N/A N/A Nickolls SA et al (2003)
mc4r_human 6.52x52 262 TM6 F => A N/A N/A Pogozheva ID et al (2005)
mc4r_human 6.54x54 264 TM6 H => A N/A N/A Yang YK et al (2000)
mc4r_human 6.54x54 264 TM6 H => A N/A N/A Pogozheva ID et al (2005)
mc4r_human 6.57x57 267 TM6 F => A N/A N/A Yang YK et al (2000)
mc4r_human 6.57x57 267 TM6 F => L N/A N/A Nickolls SA et al (2003)
mc4r_human 6.58x58 268 TM6 Y => A N/A N/A Yang YK et al (2000)
mc4r_human 6.58x58 268 TM6 Y => A N/A N/A Pogozheva ID et al (2005)
mc4r_human 6.61x61 271 TM6 C => A N/A N/A Blondet A et al (2004)
mc4r_human 6.61x61 271 TM6 C => T N/A N/A Nijenhuis WA et al (2003)
mc4r_human 6.61x61 271 TM6 C => Y N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 6.61x61 271 TM6 C => Y N/A N/A Tao YX et al (2003)
mc4r_human 6.61x61 271 TM6 C => Y N/A N/A Blondet A et al (2004)
mc4r_human 274 ECL3 N => S N/A N/A Tao YX et al (2003)
mc4r_human 7.34x33 283 TM7 H => A N/A N/A Yang YK et al (2000)
mc4r_human 7.35x34 284 TM7 F => A N/A N/A Nickolls SA et al (2003)
mc4r_human 7.36x35 285 TM7 N => A N/A N/A Yang YK et al (2000)
mc4r_human 7.46x46 295 TM7 S => P N/A N/A Tao YX et al (2005)
mc4r_human 7.49x49 298 TM7 D => A N/A N/A Yang YK et al (2000)
mc4r_human 7.50x50 299 TM7 P => H N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 7.52x52 301 TM7 I => T N/A N/A Vaisse C et al (2000)
mc4r_human 7.52x52 301 TM7 I => T N/A N/A Nijenhuis WA et al (2003)
mc4r_human 7.56x56 305 TM7 R => A N/A N/A Yang YK et al (2000)
mc4r_human 8.47x47 306 H8 S => A N/A N/A Shinyama H et al (2003)
mc4r_human 8.51x51 310 H8 R => A N/A N/A Yang Y et al (2005)
mc4r_human 8.52x52 311 H8 K => A N/A N/A Yang Y et al (2005)
mc4r_human 8.53x53 312 H8 T => A N/A N/A Shinyama H et al (2003)
mc4r_human 8.53x53 312 H8 T => A N/A N/A Yang Y et al (2005)
mc4r_human 8.54x54 313 H8 F => A N/A N/A Yang Y et al (2005)
mc4r_human 8.55x55 314 H8 K => A N/A N/A Yang Y et al (2005)
mc4r_human 8.56x56 315 H8 E => A N/A N/A Yang Y et al (2005)
mc4r_human 8.57x57 316 H8 I => A N/A N/A Yang Y et al (2005)
mc4r_human 8.57x57 316 H8 I => T N/A N/A VanLeeuwen D et al (2003)
mc4r_human 8.58x58 317 H8 I => A N/A N/A Yang Y et al (2005)
mc4r_human 8.58x58 317 H8 I => T N/A N/A Chen D et al (1999)
mc4r_human 8.58x58 317 H8 I => T N/A N/A Lubrano-Berthelier C et al (2003)
mc4r_human 8.58x58 317 H8 I => T N/A N/A VanLeeuwen D et al (2003)
mc4r_human 8.58x58 317 H8 I => T N/A N/A Nijenhuis WA et al (2003)
mc4r_human 329 C-term S => A N/A N/A Shinyama H et al (2003)
mc4r_human 330 C-term S => A N/A N/A Shinyama H et al (2003)
mc4r_human 3.25x25 122 TM3 D => A N/A N/A Fleck BA et al (2005)
mc4r_human 3.29x29 126 TM3 D => A N/A N/A Fleck BA et al (2005)
mc4r_human 5.36x36 190 TM5 S => A N/A N/A Fleck BA et al (2005)
mc4r_human 5.37x37 191 TM5 S => A N/A N/A Fleck BA et al (2005)
mc4r_human 5.46x46 200 TM5 M => A N/A N/A Fleck BA et al (2005)
mc4r_human 6.51x51 261 TM6 F => A N/A N/A Fleck BA et al (2005)
mc4r_human 7.35x34 284 TM7 F => A N/A N/A Fleck BA et al (2005)
mc4r_human 3.25x25 122 TM3 D => A N/A N/A Srinivasan S et al (2007)
mc4r_human 3.29x29 126 TM3 D => A N/A N/A Srinivasan S et al (2007)
mc4r_human 2.62x62 102 TM2 I => S N/A N/A Srinivasan S et al (2007)
mc4r_human 2.57x57 97 TM2 N => D N/A N/A Srinivasan S et al (2007)
mc4r_human 2.58x58 98 TM2 G => R N/A N/A Srinivasan S et al (2007)
mc4r_human 2.66x66 106 TM2 L => P N/A N/A Srinivasan S et al (2007)
mc4r_human 6.61x61 271 TM6 C => Y N/A N/A Srinivasan S et al (2007)
mc4r_human 2.60x60 100 TM2 E => A N/A N/A Srinivasan S et al (2007)
mc4r_human 3.30x30 127 TM3 S => L N/A N/A Srinivasan S et al (2007)
mc4r_human 34.51x51 155 ICL2 L => M N/A N/A Yang Y et al (2009)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 P G T G A I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M V N S T H R G M H T S L H L W N R S S Y R L H S N A S E S L G K G Y S D G G C Y E Q L F V N-termC-term P L G G L C D L S S R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V K R V G I I I S C I W A A C T V S G I L F I I Y S S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C H F N L Y L I L I M C N S I I D P L I Y A L R S Q E F K E Y L R K T I I C C
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G I L F I 4 Y L S A M L A L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L I F 6 L P D I I S N C M I L I L Y L N F H 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM1
1x36 1.36x36 P48
1x37 1.37x37 E49
1x38 1.38x38 V50
1x39 1.39x39 F51
1x46 1.46x46 S58
1x49 1.49x49 E61
1x50 1.50x50 N62
1x57 1.57x57 I69
TM2
2x38 2.38x38 P78
2x39 2.39x39 M79
2x44 2.44x44 C84
2x50 2.50x50 D90
2x54 2.54x54 S94
2x55 2.55x55 V95
2x57 2.57x57 N97
2x58 2.58x58 G98
2x60 2.60x60 E100
2x62 2.62x62 I102
2x63 2.63x63 V103
2x66 2.66x66 L106
TM3
3x24 3.24x24 I121
3x25 3.25x25 D122
3x28 3.28x28 I125
3x29 3.29x29 D126
3x30 3.30x30 S127
3x32 3.32x32 I129
3x33 3.33x33 C130
3x39 3.39x39 S136
3x40 3.40x40 I137
3x49 3.49x49 D146
3x53 3.53x53 T150
TM4
4x40 4.40x40 K164
4x41 4.41x41 R165
4x46 4.46x46 I170
4x50 4.50x50 W174
4x51 4.51x51 A175
4x54 4.54x54 T178
4x57 4.57x57 G181
4x60 4.60x60 F184
4x62 4.62x62 I186
TM5
5x36 5.36x36 S190
5x37 5.37x37 S191
5x41 5.41x41 I195
5x42 5.42x42 C196
5x45 5.45x45 T199
5x46 5.46x46 M200
5x47 5.47x47 F201
5x48 5.48x48 F202
5x49 5.49x49 T203
5x50 5.50x50 M204
5x60 5.60x60 H214
5x65 5.65x65 A219
TM6
6x30 6.30x30 N240
6x34 6.34x34 A244
6x40 6.40x40 L250
6x41 6.41x41 I251
6x42 6.42x42 G252
6x43 6.43x43 V253
6x48 6.48x48 W258
6x51 6.51x51 F261
6x52 6.52x52 F262
6x54 6.54x54 H264
6x57 6.57x57 F267
6x58 6.58x58 Y268
6x60 6.60x60 S270
6x61 6.61x61 C271
TM7
7x33 7.34x33 H283
7x34 7.35x34 F284
7x35 7.36x35 N285
7x39 7.40x39 I289
7x42 7.43x42 M292
7x46 7.46x46 S295
7x49 7.49x49 D298
7x50 7.50x50 P299
7x51 7.51x51 L300
7x52 7.52x52 I301
7x56 7.56x56 R305
H8
8x47 8.47x47 S306
8x51 8.51x51 R310
8x52 8.52x52 K311
8x53 8.53x53 T312
8x54 8.54x54 F313
8x55 8.55x55 K314
8x56 8.56x56 E315
8x57 8.57x57 I316
8x58 8.58x58 I317
8x59 8.59x59 C318