Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
nk2r_human 5.39x40 198 TM5 H => A N/A N/A Huang RR et al (1994)
nk2r_human 6.52x52 267 TM6 H => Y N/A N/A Huang RR et al (1994)
nk2r_human 3.28x28 109 TM3 Q => H N/A N/A Bhogal N et al (1994)
nk2r_human 3.36x36 117 TM3 M => L N/A N/A Bhogal N et al (1994)
nk2r_human 4.54x54 160 TM4 L => F N/A N/A Bhogal N et al (1994)
nk2r_human 4.61x62 167 TM4 C => G N/A N/A Bhogal N et al (1994)
nk2r_human 5.31x32 190 TM5 G => N N/A N/A Bhogal N et al (1994)
nk2r_human 5.31x32 190 TM5 G => K N/A N/A Bhogal N et al (1994)
nk2r_human 5.32x33 191 TM5 G => K N/A N/A Bhogal N et al (1994)
nk2r_human 5.35x36 194 TM5 L => E N/A N/A Bhogal N et al (1994)
nk2r_human 5.35x36 194 TM5 L => T N/A N/A Bhogal N et al (1994)
nk2r_human 5.39x40 198 TM5 H => A N/A N/A Bhogal N et al (1994)
nk2r_human 5.39x40 198 TM5 H => L N/A N/A Bhogal N et al (1994)
nk2r_human 5.43x44 202 TM5 I => V N/A N/A Bhogal N et al (1994)
nk2r_human 6.51x51 266 TM6 Y => F N/A N/A Bhogal N et al (1994)
nk2r_human 6.58x58 273 TM6 G => P N/A N/A Bhogal N et al (1994)
nk2r_human 6.58x58 273 TM6 G => T N/A N/A Bhogal N et al (1994)
nk2r_human 6.59x59 274 TM6 S => T N/A N/A Bhogal N et al (1994)
nk2r_human 6.59x59 274 TM6 S => Y N/A N/A Bhogal N et al (1994)
nk2r_human 7.38x37 292 TM7 L => I N/A N/A Bhogal N et al (1994)
nk2r_human 7.38x37 292 TM7 L => S N/A N/A Bhogal N et al (1994)
nk2r_human 6.33x33 248 TM6 F => A N/A N/A Nemeth K et al (1995)
nk2r_human 6.33x33 248 TM6 F => E N/A N/A Nemeth K et al (1995)
nk2r_human 6.33x33 248 TM6 F => S N/A N/A Nemeth K et al (1995)
nk2r_human 27 N-term S => A N/A N/A Huang RR et al (1995)
nk2r_human 24 N-term T => A N/A N/A Huang RR et al (1995)
nk2r_human 1.30x30 31 TM1 W => A N/A N/A Huang RR et al (1995)
nk2r_human 2.60x60 89 TM2 F => A N/A N/A Huang RR et al (1995)
nk2r_human 2.57x57 86 TM2 N => A N/A N/A Huang RR et al (1995)
nk2r_human 2.61x61 90 TM2 N => A N/A N/A Huang RR et al (1995)
nk2r_human 2.50x50 79 TM2 D => A N/A N/A Huang RR et al (1995)
nk2r_human 2.64x64 93 TM2 Y => A N/A N/A Huang RR et al (1995)
nk2r_human 3.28x28 109 TM3 Q => A N/A N/A Huang RR et al (1995)
nk2r_human 3.31x31 112 TM3 F => A N/A N/A Huang RR et al (1995)
nk2r_human 3.34x34 115 TM3 T => A N/A N/A Huang RR et al (1995)
nk2r_human 4.60x61 166 TM4 Q => V N/A N/A Huang RR et al (1995)
nk2r_human 5.39x40 198 TM5 H => A N/A N/A Huang RR et al (1995)
nk2r_human 5.47x47 206 TM5 Y => A N/A N/A Huang RR et al (1995)
nk2r_human 6.52x52 267 TM6 H => F N/A N/A Huang RR et al (1995)
nk2r_human 6.55x55 270 TM6 F => A N/A N/A Huang RR et al (1995)
nk2r_human 6.51x51 266 TM6 Y => A N/A N/A Huang RR et al (1995)
nk2r_human 6.51x51 266 TM6 Y => F N/A N/A Huang RR et al (1995)
nk2r_human 6.51x51 266 TM6 Y => S N/A N/A Huang RR et al (1995)
nk2r_human 7.32x31 286 TM7 Q => A N/A N/A Huang RR et al (1995)
nk2r_human 6.52x52 267 TM6 H => L N/A N/A Huang RR et al (1995)
nk2r_human 7.39x38 293 TM7 F => A N/A N/A Huang RR et al (1995)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Huang RR et al (1995)
nk2r_human 2.68x68 97 TM2 N => A N/A N/A Huang RR et al (1995)
nk2r_human 23.50x50 99 ECL1 W => A N/A N/A Huang RR et al (1995)
nk2r_human 4.64x65 170 TM4 S => A N/A N/A Huang RR et al (1995)
nk2r_human 4.63x64 169 TM4 Y => A N/A N/A Huang RR et al (1995)
nk2r_human 282 ECL3 H => A N/A N/A Huang RR et al (1995)
nk2r_human 6.59x59 274 TM6 S => A N/A N/A Huang RR et al (1995)
nk2r_human 26 N-term F => A N/A N/A Huang RR et al (1995)
nk2r_human 1.50x50 51 TM1 N => D N/A N/A Donnelly D et al (1999)
nk2r_human 1.50x50 51 TM1 N => H N/A N/A Donnelly D et al (1999)
nk2r_human 1.50x50 51 TM1 N => S N/A N/A Donnelly D et al (1999)
nk2r_human 2.50x50 79 TM2 D => A N/A N/A Donnelly D et al (1999)
nk2r_human 2.50x50 79 TM2 D => E N/A N/A Donnelly D et al (1999)
nk2r_human 2.50x50 79 TM2 D => N N/A N/A Donnelly D et al (1999)
nk2r_human 7.49x49 303 TM7 N => A N/A N/A Donnelly D et al (1999)
nk2r_human 7.49x49 303 TM7 N => D N/A N/A Donnelly D et al (1999)
nk2r_human 7.49x49 303 TM7 N => S N/A N/A Donnelly D et al (1999)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Renzetti AR et al (1999)
nk2r_human 4.60x61 166 TM4 Q => A N/A N/A Giolitti A et al (2000)
nk2r_human 4.64x65 170 TM4 S => A N/A N/A Giolitti A et al (2000)
nk2r_human 171 ECL2 T => A N/A N/A Giolitti A et al (2000)
nk2r_human 5.47x47 206 TM5 Y => A N/A N/A Giolitti A et al (2000)
nk2r_human 5.47x47 206 TM5 Y => F N/A N/A Giolitti A et al (2000)
nk2r_human 6.51x51 266 TM6 Y => A N/A N/A Giolitti A et al (2000)
nk2r_human 6.51x51 266 TM6 Y => T N/A N/A Giolitti A et al (2000)
nk2r_human 6.52x52 267 TM6 H => A N/A N/A Giolitti A et al (2000)
nk2r_human 7.35x34 289 TM7 Y => A N/A N/A Giolitti A et al (2000)
nk2r_human 7.35x34 289 TM7 Y => T N/A N/A Giolitti A et al (2000)
nk2r_human 5.39x40 198 TM5 H => A N/A N/A Renzetti AR et al (1999)
nk2r_human 6.51x51 266 TM6 Y => A N/A N/A Renzetti AR et al (1999)
nk2r_human 6.51x51 266 TM6 Y => F N/A N/A Renzetti AR et al (1999)
nk2r_human 6.55x55 270 TM6 F => A N/A N/A Renzetti AR et al (1999)
nk2r_human 7.35x34 289 TM7 Y => A N/A N/A Renzetti AR et al (1999)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Renzetti AR et al (1999)
nk2r_human 24 N-term T => C N/A N/A Labrou NE et al (2001)
nk2r_human 26 N-term F => C N/A N/A Labrou NE et al (2001)
nk2r_human 1.50x50 51 TM1 N => H N/A N/A Donnelly D et al (1999)
nk2r_human 1.50x50 51 TM1 N => S N/A N/A Donnelly D et al (1999)
nk2r_human 2.50x50 79 TM2 D => E N/A N/A Donnelly D et al (1999)
nk2r_human 2.57x57 86 TM2 N => C N/A N/A Labrou NE et al (2001)
nk2r_human 2.68x68 97 TM2 N => C N/A N/A Labrou NE et al (2001)
nk2r_human 23.50x50 99 ECL1 W => C N/A N/A Labrou NE et al (2001)
nk2r_human 3.28x28 109 TM3 Q => C N/A N/A Labrou NE et al (2001)
nk2r_human 3.28x28 109 TM3 Q => H N/A N/A Bhogal N et al (1994)
nk2r_human 3.29x29 110 TM3 N => C N/A N/A Labrou NE et al (2001)
nk2r_human 4.50x50 156 TM4 W => A N/A N/A Greenfeder S et al (1999)
nk2r_human 4.50x50 156 TM4 W => F N/A N/A Greenfeder S et al (1999)
nk2r_human 4.60x61 166 TM4 Q => A N/A N/A Greenfeder S et al (1999)
nk2r_human 4.60x61 166 TM4 Q => A N/A N/A Giolitti A et al (2000)
nk2r_human 4.64x65 170 TM4 S => A N/A N/A Giolitti A et al (2000)
nk2r_human 171 ECL2 T => A N/A N/A Giolitti A et al (2000)
nk2r_human 5.39x40 198 TM5 H => A N/A N/A Renzetti AR et al (1999)
nk2r_human 5.39x40 198 TM5 H => A N/A N/A Greenfeder S et al (1999)
nk2r_human 5.39x40 198 TM5 H => A N/A N/A Giolitti A et al (2000)
nk2r_human 5.39x40 198 TM5 H => A N/A N/A Bhogal N et al (1994)
nk2r_human 5.39x40 198 TM5 H => C N/A N/A Labrou NE et al (2001)
nk2r_human 5.39x40 198 TM5 H => F N/A N/A Greenfeder S et al (1999)
nk2r_human 5.39x40 198 TM5 H => L N/A N/A Bhogal N et al (1994)
nk2r_human 5.39x40 198 TM5 H => Q N/A N/A Greenfeder S et al (1999)
nk2r_human 5.43x44 202 TM5 I => C N/A N/A Labrou NE et al (2001)
nk2r_human 5.43x44 202 TM5 I => V N/A N/A Bhogal N et al (1994)
nk2r_human 5.45x46 204 TM5 L => A N/A N/A Greenfeder S et al (1999)
nk2r_human 5.46x461 205 TM5 I => A N/A N/A Greenfeder S et al (1999)
nk2r_human 5.47x47 206 TM5 Y => A N/A N/A Giolitti A et al (2000)
nk2r_human 5.47x47 206 TM5 Y => F N/A N/A Giolitti A et al (2000)
nk2r_human 6.33x33 248 TM6 F => A N/A N/A Nemeth K et al (1995)
nk2r_human 6.33x33 248 TM6 F => E N/A N/A Nemeth K et al (1995)
nk2r_human 6.33x33 248 TM6 F => S N/A N/A Nemeth K et al (1995)
nk2r_human 6.51x51 266 TM6 Y => A N/A N/A Renzetti AR et al (1999)
nk2r_human 6.51x51 266 TM6 Y => A N/A N/A Greenfeder S et al (1999)
nk2r_human 6.51x51 266 TM6 Y => A N/A N/A Giolitti A et al (2000)
nk2r_human 6.51x51 266 TM6 Y => C N/A N/A Labrou NE et al (2001)
nk2r_human 6.51x51 266 TM6 Y => F N/A N/A Renzetti AR et al (1999)
nk2r_human 6.51x51 266 TM6 Y => F N/A N/A Giolitti A et al (2000)
nk2r_human 6.51x51 266 TM6 Y => S N/A N/A Renzetti AR et al (1999)
nk2r_human 6.51x51 266 TM6 Y => T N/A N/A Giolitti A et al (2000)
nk2r_human 6.52x52 267 TM6 H => A N/A N/A Greenfeder S et al (1999)
nk2r_human 6.52x52 267 TM6 H => A N/A N/A Giolitti A et al (2000)
nk2r_human 6.52x52 267 TM6 H => C N/A N/A Labrou NE et al (2001)
nk2r_human 6.54x54 269 TM6 Y => A N/A N/A Greenfeder S et al (1999)
nk2r_human 6.55x55 270 TM6 F => A N/A N/A Renzetti AR et al (1999)
nk2r_human 6.55x55 270 TM6 F => A N/A N/A Giolitti A et al (2000)
nk2r_human 6.55x55 270 TM6 F => C N/A N/A Labrou NE et al (2001)
nk2r_human 6.58x58 273 TM6 G => P N/A N/A Bhogal N et al (1994)
nk2r_human 6.58x58 273 TM6 G => T N/A N/A Bhogal N et al (1994)
nk2r_human 6.59x59 274 TM6 S => A N/A N/A Greenfeder S et al (1999)
nk2r_human 7.31x30 285 TM7 I => A N/A N/A Greenfeder S et al (1999)
nk2r_human 7.35x34 289 TM7 Y => A N/A N/A Renzetti AR et al (1999)
nk2r_human 7.35x34 289 TM7 Y => A N/A N/A Greenfeder S et al (1999)
nk2r_human 7.35x34 289 TM7 Y => A N/A N/A Giolitti A et al (2000)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Renzetti AR et al (1999)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Renzetti AR et al (1999)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Greenfeder S et al (1999)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Giolitti A et al (2000)
nk2r_human 7.35x34 289 TM7 Y => T N/A N/A Giolitti A et al (2000)
nk2r_human 7.38x37 292 TM7 L => S N/A N/A Bhogal N et al (1994)
nk2r_human 7.43x42 297 TM7 M => C N/A N/A Labrou NE et al (2001)
nk2r_human 7.43x42 297 TM7 M => L N/A N/A Labrou NE et al (2001)
nk2r_human 7.49x49 303 TM7 N => A N/A N/A Donnelly D et al (1999)
nk2r_human 7.49x49 303 TM7 N => S N/A N/A Donnelly D et al (1999)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Giolitti A et al (2000)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Giolitti A et al (2000)
nk2r_human 6.55x55 270 TM6 F => A N/A N/A Giolitti A et al (2000)
nk2r_human 6.51x51 266 TM6 Y => T N/A N/A Giolitti A et al (2000)
nk2r_human 6.51x51 266 TM6 Y => F N/A N/A Giolitti A et al (2000)
nk2r_human 6.51x51 266 TM6 Y => F N/A N/A Giolitti A et al (2000)
nk2r_human 6.51x51 266 TM6 Y => A N/A N/A Giolitti A et al (2000)
nk2r_human 6.52x52 267 TM6 H => A N/A N/A Giolitti A et al (2000)
nk2r_human 5.47x47 206 TM5 Y => A N/A N/A Giolitti A et al (2000)
nk2r_human 7.49x49 303 TM7 N => S N/A N/A Donnelly D et al (1999)
nk2r_human 7.49x49 303 TM7 N => D N/A N/A Donnelly D et al (1999)
nk2r_human 7.49x49 303 TM7 N => A N/A N/A Donnelly D et al (1999)
nk2r_human 2.50x50 79 TM2 D => N N/A N/A Donnelly D et al (1999)
nk2r_human 2.50x50 79 TM2 D => E N/A N/A Donnelly D et al (1999)
nk2r_human 2.50x50 79 TM2 D => A N/A N/A Donnelly D et al (1999)
nk2r_human 1.50x50 51 TM1 N => S N/A N/A Donnelly D et al (1999)
nk2r_human 1.50x50 51 TM1 N => H N/A N/A Donnelly D et al (1999)
nk2r_human 1.50x50 51 TM1 N => D N/A N/A Donnelly D et al (1999)
nk2r_human 281 ECL3 C => Y N/A N/A Meini S et al (2009)
nk2r_human 6.51x51 266 TM6 Y => F N/A N/A Meini S et al (2009)
nk2r_human 171 ECL2 T => A N/A N/A Meini S et al (2009)
nk2r_human 3.28x28 109 TM3 Q => A N/A N/A Meini S et al (2009)
nk2r_human 6.55x55 270 TM6 F => A N/A N/A Meini S et al (2009)
nk2r_human 6.48x48 263 TM6 W => A N/A N/A Meini S et al (2009)
nk2r_human 5.47x47 206 TM5 Y => A N/A N/A Meini S et al (2009)
nk2r_human 4.61x62 167 TM4 C => G N/A N/A Meini S et al (2009)
nk2r_human 7.35x34 289 TM7 Y => F N/A N/A Meini S et al (2009)
nk2r_human 7.35x34 289 TM7 Y => T N/A N/A Meini S et al (2009)
nk2r_human 5.43x44 202 TM5 I => F N/A N/A Meini S et al (2009)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R R M R ICL1ECL1 I W Y F ECL1ICL2 P F Q P R L ICL2ECL2 T V T M D Q G A T K C V V A W P E D ECL2ICL3 Q A H G ICL3ECL3 E D I Y C H ECL3N-term M G T C D I V T E A N I S S G P E S N T T G I T A F S M N-termC-term R C C P W V T P T K E D K L E L T P T T S L S T R V N R C H T K E T L F M A G D T A P S E A T S G E A G R P Q D G S G L W F G Y G L L A P T K T H V E I C-term P S W Q L A L W A T A Y L A L V L V A V T G N A I V I W I I L A H T V T N Y F I V N L A L A D L C M A A F N A A F N F V Y A S H N G R A F C Y F Q N L F P I T A M F V S I Y S M T A I A A D R Y M A I V H S A P S T K A V I A G I W L V A L A L A S P Q C F Y S S G G K T L L L Y H L V V I A L I Y F L P L A V M F V A Y S V I G L T L W R R A V P G H A N L R H L Q A M K K F V K T M V L V V L T F A I C W L P Y H L Y F I L G S F Q K F I Q Q V Y L A L F W L A M S S T M Y N P I I Y C C L N H R F R L F R S G A F
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N G T V A V L V L A L Y A T A W L A L 1 V N L A L A D L C M A A F N A A F N F V 2 A T M S Y I S V F M A T I P F L N Q F Y 3 T K A V I A G I W L V A L A L A S P Q 4 Y A V F M V A L P L F Y I L A I V V L H Y 5 V L V V L T F A I C W L P Y H L Y F I L 6 I P N Y M T S S M A L W F L A L Y V Q 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
NK2 receptor
TM1
1x30 1.30x30 W31
1x50 1.50x50 N51
TM2
2x50 2.50x50 D79
2x57 2.57x57 N86
2x60 2.60x60 F89
2x61 2.61x61 N90
2x64 2.64x64 Y93
2x68 2.68x68 N97
TM3
3x28 3.28x28 Q109
3x29 3.29x29 N110
3x31 3.31x31 F112
3x34 3.34x34 T115
3x36 3.36x36 M117
TM4
4x50 4.50x50 W156
4x54 4.54x54 L160
4x61 4.60x61 Q166
4x62 4.61x62 C167
4x64 4.63x64 Y169
4x65 4.64x65 S170
TM5
5x32 5.31x32 G190
5x33 5.32x33 G191
5x36 5.35x36 L194
5x40 5.39x40 H198
5x44 5.43x44 I202
5x46 5.45x46 L204
5x461 5.46x461 I205
5x47 5.47x47 Y206
TM6
6x33 6.33x33 F248
6x48 6.48x48 W263
6x51 6.51x51 Y266
6x52 6.52x52 H267
6x54 6.54x54 Y269
6x55 6.55x55 F270
6x58 6.58x58 G273
6x59 6.59x59 S274
TM7
7x30 7.31x30 I285
7x31 7.32x31 Q286
7x34 7.35x34 Y289
7x37 7.38x37 L292
7x38 7.39x38 F293
7x42 7.43x42 M297
7x49 7.49x49 N303