Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
oprm_human 6 N-term A => V N/A N/A Bergen AW et al (1997)
oprm_human 6 N-term A => V N/A N/A Bond C et al (1998)
oprm_human 6 N-term A => V N/A N/A Zhang Y et al (2005)
oprm_human 40 N-term N => D N/A N/A Wand GS et al (2002)
oprm_human 40 N-term N => D N/A N/A Bergen AW et al (1997)
oprm_human 40 N-term N => D N/A N/A Bond C et al (1998)
oprm_human 40 N-term N => D N/A N/A Zhang Y et al (2005)
oprm_human 40 N-term N => D N/A N/A Mayer P et al (2006)
oprm_human 3.25x25 142 TM3 C => A N/A N/A Zhang P et al (1999)
oprm_human 3.25x25 142 TM3 C => S N/A N/A Zhang P et al (1999)
oprm_human 3.30x30 147 TM3 S => C N/A N/A Bergen AW et al (1997)
oprm_human 45.50x50 219 ECL2 C => A N/A N/A Zhang P et al (1999)
oprm_human 45.50x50 219 ECL2 C => S N/A N/A Zhang P et al (1999)
oprm_human 5.64x64 260 TM5 R => H N/A N/A Wang D et al (2001)
oprm_human 5.64x64 260 TM5 R => H N/A N/A Bond C et al (1998)
oprm_human 265 ICL3 R => H N/A N/A Wang D et al (2001)
oprm_human 268 ICL3 S => A N/A N/A Wang D et al (2001)
oprm_human 268 ICL3 S => P N/A N/A Wang D et al (2001)
oprm_human 6.26x26 273 TM6 K => A N/A N/A Wang D et al (1999)
oprm_human 6.26x26 273 TM6 K => A N/A N/A Wang D et al (2000)
oprm_human 6.26x26 273 TM6 K => A N/A N/A Wang D et al (2000)
oprm_human 6.26x26 273 TM6 K => A N/A N/A Belcheva MM et al (2001)
oprm_human 6.26x26 273 TM6 K => A N/A N/A Wang D et al (2001)
oprm_human 6.26x26 273 TM6 K => A N/A N/A Belcheva MM et al (2005)
oprm_human 6.27x27 274 TM6 D => N N/A N/A Wang D et al (2001)
oprm_human 6.28x28 275 TM6 R => A N/A N/A Wang D et al (2000)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A A P T N A S N C T D A L A Y S S C S P A P S P G S W V N L S H L D G N L S D P C G P N R T D L G G R D S L C P P T G S P S N-termC-term P T S S N I E Q Q N S T R I R Q N T R D H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M I T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G T I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I I N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L V T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I I N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7
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Residue Table


GPCRdb(A)
GPCRdb(A)
μ receptor
TM3
3x25 3.25x25 C142
3x30 3.30x30 S147
TM5
5x64 5.64x64 R260
TM6
6x26 6.26x26 K273
6x27 6.27x27 D274
6x28 6.28x28 R275