Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
cxcr2_human 8.49x49 320 H8 K => A 2.674↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.53x53 314 TM7 Y => A 2.155↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 6.33x33 249 TM6 A => L 2.398↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 1.776↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.50x50 321 H8 F => A 1.575↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.40x40 84 TM2 D => N 1.575↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => A 1.73↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.53x53 147 TM3 A => L 1.441↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => L 2.016↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.49x49 143 TM3 D => R 1.112↓ K(d) (Binding - Radioligand saturation) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.49x49 320 H8 K => A 1.818↓ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.53x53 314 TM7 Y => A 1.739↓ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 6.33x33 249 TM6 A => L 2.632↓ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 2.137↓ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.50x50 321 H8 F => A 2.754↑ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.40x40 84 TM2 D => N 1.047↑ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => A 1.202↓ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.53x53 147 TM3 A => L Abolished pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => L 2.137↓ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.49x49 143 TM3 D => R 2.188↓ pEC50 (Functional - Other) CXCL8 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.49x49 320 H8 K => A 4.444↓ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.53x53 314 TM7 Y => A 8.696↓ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 6.33x33 249 TM6 A => L 1.686↓ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 1.372↓ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.50x50 321 H8 F => A 1.887↓ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.40x40 84 TM2 D => N Abolished K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => A 5.556↓ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.53x53 147 TM3 A => L 1.543↓ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => L 1.111↑ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.49x49 143 TM3 D => R 12.048↓ K(d) (Binding - Radioligand saturation) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.49x49 320 H8 K => A 10.204↓ pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.53x53 314 TM7 Y => A Abolished pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 6.33x33 249 TM6 A => L 1.349↑ pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 1.023↑ pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.50x50 321 H8 F => A 2.755↓ pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.40x40 84 TM2 D => N 33.333↓ pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => A 8.333↓ pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.53x53 147 TM3 A => L Abolished pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => L 1.0 pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.49x49 143 TM3 D => R 14.085↓ pIC50 (Binding - Other) CHEMBL38182 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.49x49 320 H8 K => A 16.393↓ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.53x53 314 TM7 Y => A Abolished K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 6.33x33 249 TM6 A => L 14.286↓ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 1.447↓ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.50x50 321 H8 F => A 2.283↓ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.40x40 84 TM2 D => N 4.545↓ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => A 1.495↓ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.53x53 147 TM3 A => L 1.281↑ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => L 2.548↑ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.49x49 143 TM3 D => R 1.08↓ K(d) (Binding - Radioligand saturation) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.49x49 320 H8 K => A 12.346↓ pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.53x53 314 TM7 Y => A Abolished pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 6.33x33 249 TM6 A => L 12.346↓ pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 1.023↑ pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.50x50 321 H8 F => A 21.739↓ pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.40x40 84 TM2 D => N 10.0↓ pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => A 2.571↓ pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.53x53 147 TM3 A => L Abolished effect pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => L 1.778↑ pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.49x49 143 TM3 D => R 1.739↓ pIC50 (Binding - Other) CHEMBL256668 Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.49x49 320 H8 K => A 31.25↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.53x53 314 TM7 Y => A 7.042↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 6.33x33 249 TM6 A => L 250.0↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 1.844↑ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 8.50x50 321 H8 F => A 1.848↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.40x40 84 TM2 D => N 71.429↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => A 11.765↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.53x53 147 TM3 A => L 3.289↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 2.39x39 83 TM2 T => L 41.667↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 3.49x49 143 TM3 D => R 13.699↓ K(d) (Binding - Radioligand saturation) navarixin Salchow K et al (2010) Salam W et al (2025)
cxcr2_human 5.44x45 217 TM5 S => T 1.585↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.52x52 268 TM6 N => H 1.658↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.64x64 280 TM6 Q => R 1.862↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 281 ECL3 V => L 1.698↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 283 ECL3 Q => N 1.023↑ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.26x25 287 TM7 E => Q 1.949↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.33x32 294 TM7 R => Q 1.779↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 2.63x63 107 TM2 S => A 2.041↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 3.36x36 130 TM3 F => A 1.778↑ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.43x44 216 TM5 Q => E 2.457↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.47x47 220 TM5 F => L 2.188↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.55x55 271 TM6 L => A 1.658↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => S 2.288↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 2.513↓ pK(d) (Binding - Radioligand kinetics (association/dissociation)) CXCL8 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.44x45 217 TM5 S => T 1.738↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.52x52 268 TM6 N => H 3.472↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.64x64 280 TM6 Q => R 2.457↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 281 ECL3 V => L 2.237↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 283 ECL3 Q => N 2.755↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.26x25 287 TM7 E => Q 1.949↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.33x32 294 TM7 R => Q 2.755↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 2.63x63 107 TM2 S => A 3.802↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 3.36x36 130 TM3 F => A 1.35↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.43x44 216 TM5 Q => E 1.318↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.47x47 220 TM5 F => L 2.188↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.55x55 271 TM6 L => A 8.333↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => S 2.95↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 2.632↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL38182 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.44x45 217 TM5 S => T 25.641↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.52x52 268 TM6 N => H <142.857↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.64x64 280 TM6 Q => R 1.202↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 281 ECL3 V => L 1.096↑ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 283 ECL3 Q => N 1.289↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.26x25 287 TM7 E => Q 1.548↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.33x32 294 TM7 R => Q 1.381↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 2.63x63 107 TM2 S => A 2.817↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 3.36x36 130 TM3 F => A <1000.0↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.43x44 216 TM5 Q => E 5.128↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.47x47 220 TM5 F => L 12.821↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 6.55x55 271 TM6 L => A 9.091↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => S 2.457↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 7.39x38 300 TM7 E => Q 3.086↓ pK(i) (Binding - Radioligand competition/displacement) imidazolylpyrimidine 1 de Kruijf P et al (2011) Salam W et al (2025)
cxcr2_human 5.30x31 203 TM5 N => D 12.0↑ EC50 (Binding - Radioligand competition/displacement) CXCL8 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 5.33x34 206 TM5 N => K 6.0↑ EC50 (Binding - Radioligand competition/displacement) CXCL8 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 7.43x42 304 TM7 I => F 13.514↓ EC50 (Binding - Radioligand competition/displacement) CXCL8 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 7.51x51 312 TM7 L => I 4.505↓ EC50 (Binding - Radioligand competition/displacement) CXCL8 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 5.30x31 203 TM5 N => D 4.0↑ EC50 (Binding - Radioligand competition/displacement) CXCL8 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 5.33x34 206 TM5 N => K 1.2↑ EC50 (Binding - Radioligand competition/displacement) CXCL8 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 7.43x42 304 TM7 I => F 6.0↑ EC50 (Binding - Radioligand competition/displacement) CXCL8 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 7.51x51 312 TM7 L => I 1.5↑ EC50 (Binding - Radioligand competition/displacement) CXCL8 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 5.30x31 203 TM5 N => D 20.0↓ EC50 (Binding - Radioligand competition/displacement) SB-225002 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 5.33x34 206 TM5 N => K 55.556↓ EC50 (Binding - Radioligand competition/displacement) SB-225002 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 7.43x42 304 TM7 I => F 9.091↓ EC50 (Binding - Radioligand competition/displacement) SB-225002 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 7.51x51 312 TM7 L => I Other (check ref) EC50 (Binding - Radioligand competition/displacement) SB-225002 Catusse J et al (2003) Salam W et al (2025)
cxcr2_human 6.30x30 246 TM6 K => A N/A N/A Cope I et al (1997)
cxcr2_human 6.31x31 247 TM6 H => A N/A N/A Cope I et al (1997)
cxcr2_human 6.32x32 248 TM6 R => A N/A N/A Cope I et al (1997)
cxcr2_human 34.57x57 158 ICL2 K => A N/A N/A Cope I et al (1997)
cxcr2_human 34.58x58 159 ICL2 R => A N/A N/A Cope I et al (1997)
cxcr2_human 351 C-term S => A N/A N/A Schraufstatter IU et al (1998)
cxcr2_human 352 C-term S => A N/A N/A Schraufstatter IU et al (1998)
cxcr2_human 353 C-term S => A N/A N/A Schraufstatter IU et al (1998)
cxcr2_human 2.50x50 94 TM2 D => E N/A N/A Yang W et al (1997)
cxcr2_human 2.50x50 94 TM2 D => N N/A N/A Yang W et al (1997)
cxcr2_human 6.33x33 249 TM6 A => A N/A N/A Yang W et al (1997)
cxcr2_human 3.49x49 143 TM3 D => V N/A N/A Burger M et al (1999)
cxcr2_human 3.49x49 143 TM3 D => Q N/A N/A Burger M et al (1999)
cxcr2_human 7 N-term E => A N/A N/A Katancik JA et al (2000)
cxcr2_human 9 N-term D => A N/A N/A Katancik JA et al (2000)
cxcr2_human 12 N-term E => A N/A N/A Katancik JA et al (2000)
cxcr2_human 13 N-term D => A N/A N/A Katancik JA et al (2000)
cxcr2_human 2.64x64 108 TM2 K => A N/A N/A Katancik JA et al (2000)
cxcr2_human 2.66x66 110 TM2 N => A N/A N/A Katancik JA et al (2000)
cxcr2_human 3.26x26 120 TM3 K => A N/A N/A Katancik JA et al (2000)
cxcr2_human 347 C-term S => A N/A N/A Mueller SG et al (1997)
cxcr2_human 360 C-term L => A N/A N/A Snow BE et al (1998)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R Y ICL2ECL2 R T V Y S S N V S P A C Y E D M G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M E D F N M E S D S F E D F W K G E D L S N Y S Y S S T L P P F L L D A A P C E P E S L N-termC-term G L I S K D S L P K D S R P S F V G S S S G H T S T T L C-term E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F I C L S I W G L S L L L A L P V L L F R N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K L L K H F R H G I L A I
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
S N G L L S L L F V L A Y I I V V F Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F I C L S I W G L S L L L A L P V 4 Y C F L M I L L P V I F G F S Q P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 L P N L C S H L I G L I E T A D L A R 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
CXCR2
TM2
2x39 2.39x39 T83
2x40 2.40x40 D84
2x50 2.50x50 D94
2x63 2.63x63 S107
2x64 2.64x64 K108
2x66 2.66x66 N110
TM3
3x26 3.26x26 K120
3x36 3.36x36 F130
3x49 3.49x49 D143
3x53 3.53x53 A147
TM5
5x31 5.30x31 N203
5x34 5.33x34 N206
5x44 5.43x44 Q216
5x45 5.44x45 S217
5x47 5.47x47 F220
TM6
6x30 6.30x30 K246
6x31 6.31x31 H247
6x32 6.32x32 R248
6x33 6.33x33 A249
6x52 6.52x52 N268
6x55 6.55x55 L271
6x64 6.64x64 Q280
TM7
7x25 7.26x25 E287
7x32 7.33x32 R294
7x38 7.39x38 E300
7x42 7.43x42 I304
7x51 7.51x51 L312
7x53 7.53x53 Y314
H8
8x49 8.49x49 K320
8x50 8.50x50 F321